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1. Shoot the Messenger! A New Phage Weapon to Neutralize the Type III CRISPR Immune Response

Author:
Shilton, Amanda K.; Marraffini, Luciano A.
Source:
Molecular cell 2020 v.78 no.4 pp. 568-569
ISSN:
1097-2765
Subject:
neutralization,   etc   ; gene editing; immune response; second messengers;     Show all 4 Subjects
Abstract:
... Athukoralage et al. (2020) identify a new anti-CRISPR (Acr) that degrades cA₄, a cyclic oligo-adenylate second messenger produced during the type III CRISPR immune response. This provides an effective way by which invaders can bypass downstream CRISPR effectors that rely on this signaling molecule. ...
DOI:
10.1016/j.molcel.2020.04.011

2. Highly efficient transparent air filter prepared by collecting-electrode-free bipolar electrospinning apparatus

Author:
Wang, Xiaoxiong; Xiang, Hongfei; Song, Chao; Zhu, Dongyang; Sui, Jinxia; Liu, Qi; Long, Yunze
Source:
Journal of hazardous materials 2020 v.385 pp. 121535
ISSN:
0304-3894
Subject:
neutralization,   etc   ; air filters; electrodes; filtration; nanofibers;     Show all 5 Subjects
Abstract:
... Electrospinning technology has been used for a long time. A jet from a needle was formed by applying high voltage, and then the nanofibers are deposited onto a collecting electrode (usually metal) and the excess charge is conducted away to complete the electrospinning. Alternatively, it is also possible to prevent charge accumulation from hindering the progress of electrospinning by means of charg ...
DOI:
10.1016/j.jhazmat.2019.121535

3. Synergistic, antagonistic and additive antioxidant effects in the binary mixtures

Author:
Olszowy-Tomczyk, Małgorzata
Source:
Phytochemistry reviews 2020 v.19 no.1 pp. 63-103
ISSN:
1568-7767
Subject:
neutralization,   etc   ; antioxidant activity; antioxidants; ingredients; solvents; synergism;     Show all 6 Subjects
Abstract:
... Food which is consumed by living organisms contains many antioxidants often with different antioxidant abilities. In the case of antioxidants mixture its potential is not always an additive value of antioxidant properties of their individual ingredients. Despite the extensive research there is still no knowledge about the reasons for observing the antioxidant antagonism and synergism in mixtures. ...
DOI:
10.1007/s11101-019-09658-4

4. Expansion of the 1st WHO international standard for antiserum to respiratory syncytial virus to include neutralisation titres against RSV subtype B: An international collaborative study

Author:
McDonald, Jacqueline U.; Rigsby, Peter; Atkinson, Eleanor; Engelhardt, Othmar G.
Source:
Vaccine 2020 v.38 no.4 pp. 800-807
ISSN:
0264-410X
Subject:
neutralization; neutralization tests,   etc   ; Respiratory syncytial virus; antiserum; blood serum; complement; globulins; humans; monoclonal antibodies; vaccines; viruses;     Show all 11 Subjects
Abstract:
... An International Standard to harmonise results from RSV subtype A neutralisation assays was generated and established by the World Health Organization in 2018. Here we report on a study to expand the use of that standard to include neutralisation assays using human sera against RSV subtype B and to test its ability to harmonise neutralisation titres from neutralisation assays including complement. ...
DOI:
10.1016/j.vaccine.2019.10.095

5. Crisis events and the inter-scalar politics of humor

Author:
Ridanpää, Juha
Source:
GeoJournal 2019 v.84 no.4 pp. 901-915
ISSN:
0343-2521
Subject:
neutralization,   etc   ; contemporary society; politics;     Show all 3 Subjects
Abstract:
... Although humor is generally associated with innocent amusement, in the case of crisis events it has various psychological, social and politically charged effects, both negative and positive. In times of crisis humor functions as a technique for neutralizing emotionally charged areas and by that means provides hope. On the other hand, in contemporary society there exist sensitive socially restricte ...
DOI:
10.1007/s10708-018-9900-5

6. Apoplastic effector proteins of plant-associated fungi and oomycetes

Author:
Rocafort, Mercedes; Fudal, Isabelle; Mesarich, Carl H
Source:
Current opinion in plant biology 2020 v.56 pp. 9-19
ISSN:
1369-5266
Subject:
neutralization,   etc   ; Oomycetes; anti-infective agents; apoplast; fungi; immunity; immunologic receptors;     Show all 7 Subjects
Abstract:
... The outcome of an interaction between a plant and a fungus or an oomycete, whether compatibility or incompatibility, is often determined in the hostile extracellular spaces and matrices of the apoplast. Indeed, for compatibility to occur, many plant-associated fungi and oomycetes must first neutralize the apoplast, which is both monitored by plant cell-surface immune receptors, and enriched in pla ...
DOI:
10.1016/j.pbi.2020.02.004

7. Obsessive compulsive disorder and thought action fusion: Relationships with eating disorder outcomes

Author:
Lee, Eric B.; Barney, Jennifer L.; Twohig, Michael P.; Lensegrav-Benson, Tera; Quakenbush, Benita
Source:
Eating behaviors 2020 v.37 pp. 101386
ISSN:
1471-0153
Subject:
neutralization,   etc   ; adolescents; adults; cognition; comorbidity; eating disorders; females; patients;     Show all 8 Subjects
Abstract:
... Obsessive Compulsive Disorder (OCD) is among the most common psychiatric comorbidities with eating disorders (EDs) and most studies have only examined this relationship at a diagnostic level. More research is needed to determine whether specific symptom domains and cognitive patterns commonly observed in OCD are most salient among individuals with clinically significant EDs, and whether these symp ...
DOI:
10.1016/j.eatbeh.2020.101386

8. Development of anti-drug monoclonal antibody panels against adalimumab and infliximab

Author:
Suzuki, Takuo; Tada, Minoru; Ishii-Watabe, Akiko
Source:
Biologicals 2020 v.63 pp. 39-47
ISSN:
1045-1056
Subject:
neutralization,   etc   ; humans; models; monoclonal antibodies; neutralizing antibodies; patients; pharmacokinetics; therapeutics;     Show all 8 Subjects
Abstract:
... The generation of anti-drug antibodies (ADAs) is one of the most serious problems in therapy using monoclonal antibodies (mAbs), because ADAs can impact the pharmacokinetics, efficacy, and safety of mAbs. It is therefore important to detect the generated ADAs in patients. For the appropriate detection of ADAs, methods that detect various types of ADAs (e.g., low- and high-affinity ADAs) are needed ...
DOI:
10.1016/j.biologicals.2019.12.003

9. Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs

Author:
Seaman, Michael S.; Bilska, Miroslawa; Ghantous, Fadi; Eaton, Amanda; LaBranche, Celia C.; Greene, Kelli; Gao, Hongmei; Weiner, Joshua A.; Ackerman, Margaret E.; Garber, David A.; Rosenberg, Yvonne J.; Sarzotti-Kelsoe, Marcella; Montefiori, David C.
Source:
Journal of immunological methods 2020 v.479 pp. 112736
ISSN:
0022-1759
Subject:
neutralization; neutralization tests,   etc   ; HIV infections; Human immunodeficiency virus 1; Primates; detection limit; drugs; humans; monoclonal antibodies; patients; therapeutics;     Show all 11 Subjects
Abstract:
... The recent identification of human monoclonal antibodies with broad and potent neutralizing activity against HIV-1 (bnAbs) has resulted in substantial efforts to develop these molecules for clinical use in the prevention and treatment of HIV-1 infection. As with any protein therapeutic drug product, it is imperative to have qualified assays that can accurately detect and quantify anti-drug antibod ...
DOI:
10.1016/j.jim.2020.112736
PubMed:
31917969
PubMed Central:
PMC7103754

10. Selection of Affinity Reagents to Neutralize the Hemolytic Toxicity of Melittin Based on a Self-Assembled Nanoparticle Library

Author:
Xu, Yaqing; Deng, Meitao; Zhang, Haitao; Tan, Sha; Li, Dan; Li, Shaoyuan; Luo, Lei; Liao, Guofu; Wang, Qing; Huang, Jin; Liu, Jianbo; Yang, Xiaohai; Wang, Kemin
Source:
ACS applied materials & interfaces 2020 v.12 no.14 pp. 16040-16049
ISSN:
1944-8252
Subject:
neutralization; neutralization tests,   etc   ; Staphylococcus aureus; antibodies; beta-cyclodextrin; cytotoxicity; hemolysis; melittin; nanoparticles; polymers; polypeptides; surface plasmon resonance;     Show all 12 Subjects
Abstract:
... Antibodies are the most common affinity reagents for specific target recognition. However, their applications are limited by high cost and low stability. Thus, seeking substitutes for antibodies is of great significance. In this work, we designed a library containing 82 self-assembled nanoparticles (SNPs) based on the self-assembly of β-cyclodextrin polymers and adamantane derivatives, and then sc ...
DOI:
10.1021/acsami.0c00303

11. Optimized coagulation pathway of Al13: Effect of in-situ Aggregation of Al13

Author:
Wang, Pin; Jiao, Ruyuan; Liu, Libing; Xiao, Feng; An, Guangyu; Wang, Dongsheng
Source:
Chemosphere 2019 v.230 pp. 76-83
ISSN:
0045-6535
Subject:
neutralization,   etc   ; aluminum; coagulation; pH; silica;     Show all 5 Subjects
Abstract:
... The coagulation mechanism for removing particles by Al13 has been extensively investigated for water treatments. It was widely accepted that Al13 played important roles in coagulation mainly by charge neutralization and electrostatic patch. However, the discovery of Al13 aggregates (Al13agg) in flocs indicated that the real coagulation process should be different from the previous understanding, i ...
DOI:
10.1016/j.chemosphere.2019.05.053

12. Improved lightning model: Application to discuss the characteristics of upward lightning

Author:
Tan, Yongbo; Zheng, Tianxue; Shi, Zheng
Source:
Atmospheric research 2019 v.217 pp. 63-72
ISSN:
0169-8095
Subject:
neutralization,   etc   ; electric field; lightning; models;     Show all 4 Subjects
Abstract:
... A stochastic discharge parameterization scheme of upward lightning is presented and embedded into an existing fine resolution two-dimensional thundercloud electrification and lightning model. At present, our lightning model can simulate not only intra-cloud (IC) lightning and cloud-to-ground (CG) lightning but also upward lightning. By this improved model, 139 upward flashes originating from the t ...
DOI:
10.1016/j.atmosres.2018.10.011

13. Detection of porcine epidemic diarrhea virus–neutralizing antibody using high-throughput imaging cytometry

Author:
Sarmento, Luciana V.; Poonsuk, Korakrit; Tian, Liying; Mora-Díaz, Juan C.; Main, Rodger G.; Baum, David H.; Zimmerman, Jeffrey J.; Giménez-Lirola, Luis G.
Source:
Journal of veterinary diagnostic investigation 2020 v.32 no.2 pp. 324-328
ISSN:
1943-4936
Subject:
neutralization; neutralization tests,   etc   ; Porcine epidemic diarrhea virus; animal viruses; blood serum; diagnostic sensitivity; diarrhea; fluorescence; herd immunity; humans; image analysis; neutralizing antibodies; pork industry; storage time; swine;     Show all 15 Subjects
Abstract:
... Porcine epidemic diarrhea virus (PEDV) is an emerging porcine coronavirus that causes a tremendous economic burden on the swine industry. The assessment of PEDV-neutralizing antibody levels provides a valuable tool to assess and predict herd immunity. We evaluated the performance of a PEDV imaging cytometry–based high-throughput neutralization test (HTNT) and compared the HTNT to a fluorescent foc ...
DOI:
10.1177/1040638720903346
PubMed:
32065056
PubMed Central:
PMC7081499

14. Humoral immunity to tetanus, diphtheria and polio in adults after treatment for hematological malignancies

Author:
Einarsdottir, Sigrun; Ljungman, Per; Kaijser, Bertil; Nicklasson, Malin; Horal, Peter; Norder, Helen; Bergström, Tomas; Brune, Mats
Source:
Vaccine 2020 v.38 no.5 pp. 1084-1088
ISSN:
0264-410X
Subject:
neutralization; neutralization tests,   etc   ; Enterovirus C; adults; antibodies; children; diphtheria; drug therapy; enzyme-linked immunosorbent assay; humoral immunity; lymphocytic leukemia; lymphoma; patients; serology; serotypes; tetanus; vaccines;     Show all 17 Subjects
Abstract:
... After chemotherapy, children with acute lymphocytic leukemia lose immunity and need revaccination against tetanus and diphtheria. However, little is known about immunity in adult patients after treatment for hematological malignancies. In this study, we assessed serology levels against polio, diphtheria and tetanus in adult patients after conventional treatment for leukemia and lymphoma.One hundre ...
DOI:
10.1016/j.vaccine.2019.11.034

15. Identification of the immunodominant neutralizing regions in the spike glycoprotein of porcine deltacoronavirus

Author:
Chen, Rui; Fu, Jiayu; Hu, Jingfei; Li, Cheng; Zhao, Yujia; Qu, Huan; Wen, Xintian; Cao, Sanjie; Wen, Yiping; Wu, Rui; Zhao, Qin; Yan, Qigui; Huang, Yong; Ma, Xiaoping; Han, Xinfeng; Huang, Xiaobo
Source:
Virus research 2020 v.276 pp. 197834
ISSN:
0168-1702
Subject:
neutralization; neutralization tests,   etc   ; Deltacoronavirus; Escherichia coli; amino acid sequences; amino acids; antiserum; epitopes; fluorescence; glycoproteins; mice; neutralizing antibodies; rabbits; recombinant proteins; swine; swine diseases; vaccines;     Show all 17 Subjects
Abstract:
... Porcine deltacoronavirus (PDCoV), is an emerging enteropathogenic coronavirus in pigs, that poses a novel threat to swine husbandry worldwide. Crucial to halting PDCoV transmission and infection is the development of effective therapies and vaccines. The spike (S) protein of coronavirus is the major target of host neutralizing antibodies, however the immunodominant neutralizing region in the S pro ...
DOI:
10.1016/j.virusres.2019.197834
PubMed:
31816342
PubMed Central:
PMC7114822

16. Precise location of linear epitopes on the capsid surface of feline calicivirus recognized by neutralizing and non-neutralizing monoclonal antibodies

Author:
Cubillos-Zapata, Carolina; Angulo, Iván; Almanza, Horacio; Borrego, Belén; Zamora-Ceballos, María; Castón, José R.; Mena, Ignacio; Blanco, Esther; Bárcena, Juan
Source:
Veterinary research 2020 v.51 no.1 pp. 59
ISSN:
1297-9716
Subject:
neutralization,   etc   ; Feline calicivirus; amino acids; capsid; coat proteins; epitope mapping; epitopes; monoclonal antibodies; viral antigens;     Show all 9 Subjects
Abstract:
... We report the generation, characterization and epitope mapping of a panel of 26 monoclonal antibodies (MAbs) against the VP1 capsid protein of feline calicivirus (FCV). Two close but distinct linear epitopes were identified at the capsid outermost surface (P2 subdomain) of VP1, within the E5′HVR antigenic hypervariable region: one spanning amino acids 431-435 (PAGDY), highly conserved and recogniz ...
DOI:
10.1186/s13567-020-00785-x
PubMed:
32357948
PubMed Central:
PMC7195702

17. Using cluster analysis to reconstruct dengue exposure patterns from cross-sectional serological studies in Singapore

Author:
Sangkaew, Sorawat; Tan, Li Kiang; Ng, Lee Ching; Ferguson, Neil M.; Dorigatti, Ilaria
Source:
Parasites & vectors 2020 v.13 no.1 pp. 32
ISSN:
1756-3305
Subject:
neutralization tests,   etc   ; algorithms; antibodies; artificial intelligence; cluster analysis; data collection; dengue; immunity; serological surveys; serotypes; Singapore;     Show all 11 Subjects
Abstract:
... BACKGROUND: Dengue is a mosquito-borne viral disease caused by one of four serotypes (DENV1-4). Infection provides long-term homologous immunity against reinfection with the same serotype. Plaque reduction neutralization test (PRNT) is the gold standard to assess serotype-specific antibody levels. We analysed serotype-specific antibody levels obtained by PRNT in two serological surveys conducted i ...
DOI:
10.1186/s13071-020-3898-5
PubMed:
31952539
PubMed Central:
PMC6969465

18. Open source, low-cost device for thermometric titration with non-contact temperature measurement

Author:
Alessio, Keiti O.; Tischer, Bruna; Voss, Mônica; Teixeira, Iberê D.; Brendler, Bruno M.; Duarte, Fabio A.; Helfer, Gilson A.; Costa, Adilson B.; Barin, Juliano S.
Source:
Talanta 2020 v.216 pp. 120975
ISSN:
0039-9140
Subject:
neutralization,   etc   ; acidity; ascorbic acid; calcium; cameras; computer software; drugs; monitoring; polystyrenes; sauces; syringes; temperature; titration;     Show all 13 Subjects
Abstract:
... This work proposes a simple device for thermometric titration using a contactless sensor. A low-cost infrared sensor (around $5) was adapted in a disposable, polystyrene vessel for monitoring the temperature to determine the endpoint of neutralization, redox, and complexation titrations, using a homemade syringe pump to titration control. Open-source software was developed to control the device us ...
DOI:
10.1016/j.talanta.2020.120975

19. Modification of food preferences by posthypnotic suggestions: An event-related brain potential study

Author:
Zahedi, Anoushiravan; Łuczak, Aleksandra; Sommer, Werner
Source:
Appetite 2020 v.151 pp. 104713
ISSN:
0195-6663
Subject:
neutralization,   etc   ; brain; emotions; food choices; fruits; high energy foods; low calorie foods; monitoring; salads; vegetables;     Show all 10 Subjects
Abstract:
... The preference for high-over low-calorie food and difficulties in inhibiting the desire for high-calorie food are important factors involved in unhealthy food choices. Here, we explored posthypnotic suggestions (PHS), aiming to increase the desire for vegetables and fruits, as a possible new tool to induce a preference for low-calorie food. Following the termination of hypnosis, PHS was activated ...
DOI:
10.1016/j.appet.2020.104713

20. Coxsackievirus B4 infection and interneuronal spread in primary cultured neurons

Author:
Jmii, Habib; Halouani, Aymen; Maatouk, Mouna; Chekir-Ghedira, Leila; Aouni, Mahjoub; Fisson, Sylvain; Jaïdane, Hela
Source:
Microbial pathogenesis 2020 v.145 pp. 104235
ISSN:
0882-4010
Subject:
neutralization,   etc   ; blood flow; blood serum; cell viability; central nervous system; fibroblasts; mice; neurons; viral load; viruses;     Show all 10 Subjects
Abstract:
... Coxsackie B viruses (CV–B) are usually transmitted via the fecal-oral route and the virus gains the central nervous system (CNS) via the bloodstream. Nevertheless, other routes of spread of the virus to the CNS cannot be excluded, including the neuronal route. Neuronal cells, as well as non-neuronal cells (fibroblasts), were isolated from mice and inoculated with CV-B4 in the absence and presence ...
DOI:
10.1016/j.micpath.2020.104235