You searched for:
Subject
"neutralizing antibodies"
Remove constraint Subject: "neutralizing antibodies"
PubAg
Main content area
Limit your search
Search
2,291 Search Results
« Previous |
1 - 20 of 2,291
|
Next »
Search Results
- Author:
- Marc H. V. van Regenmortel
- Source:
- Archives of virology 2021 v.166 no.1 pp. 27-33
- ISSN:
- 0304-8608
- Subject:
- neutralizing antibodies, etc ; antibody binding sites; antiretroviral agents; design; epitopes; immune system; immunogenicity; knowledge; research; vaccines; virology; Show all 11 Subjects
- Abstract:
- ... This review argues that the three popular concepts of design, rationality and reductionism, which guided vaccine research for many years, actually contributed to the inability of vaccinologists to develop an effective HIV vaccine. The strong goal-directed intentionality inherent in the concept of design together with excessive confidence in the power of rational thinking convinced investigators th ...
- DOI:
- 10.1007/s00705-020-04884-0
- https://doi.org/10.1007/s00705-020-04884-0
- Author:
- Sai Priya Anand; Jérémie Prévost; Jade Descôteaux-Dinelle; Jonathan Richard; Dung N. Nguyen; Halima Medjahed; Hung-Ching Chen; Amos B. Smith; Marzena Pazgier; Andrés Finzi
- Source:
- Viruses 2021 v.13 no.10 pp. -
- ISSN:
- 1999-4915
- Subject:
- broadly neutralizing antibodies, etc ; glycoproteins; immune response; surfaces; viruses; Show all 5 Subjects
- Abstract:
- ... To minimize immune responses against infected cells, HIV-1 has evolved different mechanisms to limit the surface expression of its envelope glycoproteins (Env). Recent observations suggest that the binding of certain broadly neutralizing antibodies (bNAbs) targeting the ‘closed’ conformation of Env induces its internalization. On the other hand, non-neutralizing antibodies (nNAbs) that preferentia ...
- DOI:
- 10.3390/v13101953
- https://doi.org/10.3390/v13101953
- Author:
- Adriana Tomic; Andrew J. Pollard; Mark M. Davis
- Source:
- Viruses 2021 v.13 no.5 pp. -
- ISSN:
- 1999-4915
- Subject:
- neutralizing antibodies, etc ; Influenza A virus; T-lymphocytes; adaptive immunity; antibody formation; computational methodology; disease control; genetic factors; influenza; pandemic; vaccines; viruses; Show all 12 Subjects
- Abstract:
- ... Understanding protective influenza immunity and identifying immune correlates of protection poses a major challenge and requires an appreciation of the immune system in all of its complexity. While adaptive immune responses such as neutralizing antibodies and influenza-specific T lymphocytes are contributing to the control of influenza virus, key factors of long-term protection are not well define ...
- DOI:
- 10.3390/v13050948
- https://doi.org/10.3390/v13050948
- Author:
- Saman Fouladirad; Horacio Bach
- Source:
- Microorganisms 2021 v.9 no.1 pp. -
- ISSN:
- 2076-2607
- Subject:
- neutralizing antibodies, etc ; Coronavirus infections; Orthocoronavirinae; World Health Organization; administrative management; blood serum; clinical trials; immunoglobulins; immunotherapy; intravenous injection; monoclonal antibodies; oxygen; viruses; China; Show all 14 Subjects
- Abstract:
- ... The Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus SARS-CoV-2, was first reported in December 2019 in Wuhan, Hubei province, China. This virus has led to 61.8 million cases worldwide being reported as of December 1st, 2020. Currently, there are no definite approved therapies endorsed by the World Health Organization for COVID-19, focusing only on supportive care. Treatment ce ...
- DOI:
- 10.3390/microorganisms9010165
- https://doi.org/10.3390/microorganisms9010165
- Author:
- Chang Liu; Helen M. Ginn; Wanwisa Dejnirattisai; Piyada Supasa; Beibei Wang; Aekkachai Tuekprakhon; Rungtiwa Nutalai; Daming Zhou; Alexander J. Mentzer; Yuguang Zhao; Helen M.E. Duyvesteyn; César López-Camacho; Jose Slon-Campos; Thomas S. Walter; Donal Skelly; Sile Ann Johnson; Thomas G. Ritter; Chris Mason; Sue Ann Costa Clemens; Felipe Gomes Naveca; Valdinete Nascimento; Fernanda Nascimento; Cristiano Fernandes da Costa; Paola Cristina Resende; Alex Pauvolid-Correa; Marilda M. Siqueira; Christina Dold; Nigel Temperton; Tao Dong; Andrew J. Pollard; Julian C. Knight; Derrick Crook; Teresa Lambe; Elizabeth Clutterbuck; Sagida Bibi; Amy Flaxman; Mustapha Bittaye; Sandra Belij-Rammerstorfer; Sarah C. Gilbert; Tariq Malik; Miles W. Carroll; Paul Klenerman; Eleanor Barnes; Susanna J. Dunachie; Vicky Baillie; Natali Serafin; Zanele Ditse; Kelly Da Silva; Neil G. Paterson; Mark A. Williams; David R. Hall; Shabir Madhi; Marta C. Nunes; Philip Goulder; Elizabeth E. Fry; Juthathip Mongkolsapaya; Jingshan Ren; David I. Stuart; Gavin R. Screaton
- Source:
- Cell 2021 v.184 no.16 pp. 4220-4236.e13
- ISSN:
- 0092-8674
- Subject:
- neutralizing antibodies, etc ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antigenic variation; antiserum; monoclonal antibodies; vaccination; viral antibodies; viral antigens; viral vaccines; Show all 10 Subjects
- Abstract:
- ... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 has contributed to the current wave of infection ravaging the Indian subcontinent and has been designated a variant of concern in the United Kingdom. Here we s ...
- DOI:
- 10.1016/j.cell.2021.06.020
- https://doi.org/10.1016/j.cell.2021.06.020
- Author:
- Shylo R. Johnson; Dennis Slate; Kathleen M. Nelson; Amy J. Davis; Samual A. Mills; John T. Forbes; Kurt C. VerCauteren; Amy T. Gilbert; Richard B. Chipman
- Source:
- Viruses 2021 v.13 no.2 pp. -
- ISSN:
- 1999-4915
- Subject:
- neutralizing antibodies, etc ; Mephitis mephitis; Procyon lotor; Rabies lyssavirus; baits; disease control; edible vaccines; oral vaccination; rabies; seroprevalence; skunks; viral vaccines; wildlife; West Virginia; Show all 14 Subjects
- Abstract:
- ... Since the 1990s, oral rabies vaccination (ORV) has been used successfully to halt the westward spread of the raccoon rabies virus (RV) variant from the eastern continental USA. Elimination of raccoon RV from the eastern USA has proven challenging across targeted raccoon (Procyon lotor) and striped skunk (Mephitis mephitis) populations impacted by raccoon RV. Field trial evaluations of the Ontario ...
- DOI:
- 10.3390/v13020157
- https://doi.org/10.3390/v13020157
- Author:
- Takuo Suzuki; Minoru Tada; Akiko Ishii-Watabe
- Source:
- Biologicals 2020 v.63 pp. 39-47
- ISSN:
- 1045-1056
- Subject:
- neutralizing antibodies, etc ; humans; models; monoclonal antibodies; neutralization; patients; pharmacokinetics; therapeutics; Show all 8 Subjects
- Abstract:
- ... The generation of anti-drug antibodies (ADAs) is one of the most serious problems in therapy using monoclonal antibodies (mAbs), because ADAs can impact the pharmacokinetics, efficacy, and safety of mAbs. It is therefore important to detect the generated ADAs in patients. For the appropriate detection of ADAs, methods that detect various types of ADAs (e.g., low- and high-affinity ADAs) are needed ...
- DOI:
- 10.1016/j.biologicals.2019.12.003
- https://doi.org/10.1016/j.biologicals.2019.12.003
- Author:
- Kosuke Murakami; Yoshiki Fujii; Yuichi Someya
- Source:
- Vaccine 2020 v.38 no.17 pp. 3295-3299
- ISSN:
- 0264-410X
- Subject:
- neutralizing antibodies, etc ; denaturation; heat treatment; immunogenicity; quality control; rats; vaccines; Japan; Show all 8 Subjects
- Abstract:
- ... The efficacy of a Sabin-derived inactivated polio vaccine (sIPV) can be evaluated by measuring the immunogenicity and the contents of D-antigens, which induce the neutralizing antibodies. The immunogenic potency test in rats was done as a national assay in Japan. The two manufacturers of sIPV in Japan have performed both assays since development, and there is no clear discrepancy between the resul ...
- DOI:
- 10.1016/j.vaccine.2020.03.027
- https://doi.org/10.1016/j.vaccine.2020.03.027
- Author:
- Jin Kyeong Choi; Charles E. Egwuagu
- Source:
- Journal of molecular biology 2021 v.433 no.1 pp. 166607
- ISSN:
- 0022-2836
- Subject:
- neutralizing antibodies, etc ; B-lymphocytes; autoimmune diseases; central nervous system; humoral immunity; immune response; interleukin-10; measles; neoplasm cells; neutralization; pathogens; smallpox; therapeutics; transforming growth factor beta; Show all 14 Subjects
- Abstract:
- ... B lymphocytes play a central role in host immunity. They orchestrate humoral immune responses that modulate activities of other immune cells and produce neutralizing antibodies that confer lasting immunity to infectious diseases including smallpox, measles and poliomyelitis. In addition to these traditional functions is the recent recognition that B cells also play critical role in maintaining per ...
- DOI:
- 10.1016/j.jmb.2020.07.019
- https://doi.org/10.1016/j.jmb.2020.07.019
10. Preclinical study of influenza bivalent vaccine delivered with a two compartmental microneedle array
- Author:
- Hye-Rin Jeong; Joon-Yong Bae; Jee-Hyun Park; Seung-Ki Baek; Gayeong Kim; Man-Seong Park; Jung-Hwan Park
- Source:
- Journal of controlled release 2020 v.324 pp. 280-288
- ISSN:
- 0168-3659
- Subject:
- neutralizing antibodies, etc ; dipping; equipment; influenza; influenza vaccines; mice; mixing; neutralization tests; viruses; Show all 9 Subjects
- Abstract:
- ... Multiple vaccines can be mixed into a single combination to be a single product. However, combination vaccines have problems of complexity. In this study, microneedles were utilized in a compartmental microneedle array (CMA) to deliver two influenza vaccine strains without mixing.In this study, the CMA had two compartments, and two rectangular structures were attached to each end of the array to e ...
- DOI:
- 10.1016/j.jconrel.2020.05.024
- https://doi.org/10.1016/j.jconrel.2020.05.024
- Author:
- Julie Gilbert; Jhansi Leslie; Rose Putler; Shayna Weiner; Alexandra Standke; Aline Penkevich; Micah Keidan; Vincent B. Young; Krishna Rao
- Source:
- Anaerobe 2021 v.67 pp. 102299
- ISSN:
- 1075-9964
- Subject:
- neutralizing antibodies, etc ; Clostridium difficile; adults; antibody formation; bias; cohort studies; detection; enzyme-linked immunosorbent assay; history; infection; patients; regression analysis; risk; risk reduction; testing; toxins; Michigan; Show all 17 Subjects
- Abstract:
- ... Clostridium difficile infection (CDI) recurs in ∼20% of patients. Prior studies indicated that antibody responses directed against the C. difficile toxins A and B were potentially associated with lower risk of recurrent CDI. Here we tested the hypothesis that circulating anti-toxin IgG antibody levels associate with reduced risk of recurrent CDI. A cohort study with prospective enrollment and retr ...
- DOI:
- 10.1016/j.anaerobe.2020.102299
- https://doi.org/10.1016/j.anaerobe.2020.102299
- Author:
- Marija Brgles; Tihana Kurtović; Maja Lang Balija; Ana Hećimović; Tatjana Mušlin; Beata Halassy
- Source:
- Journal of immunological methods 2021 v.490 pp. 112957
- ISSN:
- 0022-1759
- Subject:
- neutralizing antibodies, etc ; Measles morbillivirus; Mumps orthorubulavirus; blood serum; cell culture; complement; correlation; dosage; enzyme-linked immunosorbent assay; guinea pigs; heat inactivation; humans; immunoglobulins; literature; measles; measurement; neutralization; neutralization tests; Show all 18 Subjects
- Abstract:
- ... Neutralizing antibodies against mumps and measles virus are considered a correlate of protection against these diseases. Measurement of neutralizing antibodies is mostly performed using plaque reduction neutralization assay or 50% cell culture infective dose (CCID₅₀) neutralization assay, but there are attempts for measuring neutralizing antibodies using enzyme-linked immunosorbent assay (ELISA) w ...
- DOI:
- 10.1016/j.jim.2021.112957
- https://doi.org/10.1016/j.jim.2021.112957
- Author:
- Pranay Bharadwaj; Cassidy Riekofski; Shu Lin; Michael S. Seaman; David A. Garber; David Montefiori; Marcella Sarzotti-Kelsoe; Margaret E. Ackerman; Joshua A. Weiner
- Source:
- Journal of immunological methods 2020 v.479 pp. 112764
- ISSN:
- 0022-1759
- Subject:
- neutralizing antibodies, etc ; Human immunodeficiency virus; Primates; clinical trials; compliance; drugs; immune response; industry; therapeutics; Show all 9 Subjects
- Abstract:
- ... The ability to detect, quantify, and interrogate the properties of immune responses raised against biological therapeutics is not only important to our understanding of these molecules, but also to their success in the clinic. A tiered assay approach to identify the presence, specificity, and titer of anti-drug antibody (ADA) responses has been adopted as a gold standard by industry leaders, the F ...
- DOI:
- 10.1016/j.jim.2020.112764
- PubMed:
- 32070674
- PubMed Central:
- PMC7103756
- https://doi.org/10.1016/j.jim.2020.112764
- Author:
- M. Gordon Joyce; Adam K. Wheatley; Kayvon Modjarrad
- Source:
- Cell 2020 v.182 no.1 pp. 7-9
- ISSN:
- 0092-8674
- Subject:
- neutralizing antibodies, etc ; Severe acute respiratory syndrome coronavirus 2; glycoproteins; humans; immunity; monoclonal antibodies; neutralization; Show all 7 Subjects
- Abstract:
- ... The emergence of SARS-CoV-2 has driven a global research effort to identify medical countermeasures at an unprecedented pace. In this issue of Cell, Cao et al. identify thousands of SARS-CoV-2 neutralizing antibodies from convalescent donors. The authors improve our understanding of immunity against the coronavirus spike glycoprotein and detail novel pathways to rapidly identify and characterize p ...
- DOI:
- 10.1016/j.cell.2020.06.017
- https://doi.org/10.1016/j.cell.2020.06.017
- Author:
- Alexander Thomas Sampson; Jonathan Heeney; Diego Cantoni; Matteo Ferrari; Maria Suau Sans; Charlotte George; Cecilia Di Genova; Martin Mayora Neto; Sebastian Einhauser; Benedikt Asbach; Ralf Wagner; Helen Baxendale; Nigel Temperton; George Carnell
- Source:
- Viruses 2021 v.13 no.8 pp. -
- ISSN:
- 1999-4915
- Subject:
- broadly neutralizing antibodies, etc ; Betacoronavirus 1; COVID-19 infection; Severe acute respiratory syndrome coronavirus; Severe acute respiratory syndrome coronavirus 2; cross reaction; disease progression; humans; immunopathology; neutralization; seroprevalence; transfection; vaccination; Show all 13 Subjects
- Abstract:
- ... The novel coronavirus SARS-CoV-2 is the seventh identified human coronavirus. Understanding the extent of pre-existing immunity induced by seropositivity to endemic seasonal coronaviruses and the impact of cross-reactivity on COVID-19 disease progression remains a key research question in immunity to SARS-CoV-2 and the immunopathology of COVID-2019 disease. This paper describes a panel of lentivir ...
- DOI:
- 10.3390/v13081579
- https://doi.org/10.3390/v13081579
- Author:
- Alireza Gholami; Mohammad-Reza Shirzadi; Mohsen Asouri; Firouzeh Farahtaj; Ehsan Mostafavi; Safoora Gharibzadeh; Jamshid Pourmozafari; Mahmoud Nabavi; Fazlollah Nazari; Fariborz Bahrami
- Source:
- Virus research 2020 v.278 pp. 197883
- ISSN:
- 0168-1702
- Subject:
- neutralizing antibodies, etc ; cats; disease control; dogs; humans; immunity; people; rabies; seroconversion; vaccination; vaccines; Iran; Show all 12 Subjects
- Abstract:
- ... Rabies is still threatening half of the world’s population with the global burden of canine rabies being estimated as 59,000 human deaths, annually. With no cure existing for clinical rabies, post-exposure prophylaxis (PEP) is the only certain means to save lives of the exposed people. In Iran, bite incidences exceed 180,000 per year, where all victims receive 5 vaccine doses for PEP, conforming t ...
- DOI:
- 10.1016/j.virusres.2020.197883
- https://doi.org/10.1016/j.virusres.2020.197883
- Author:
- Jessica B. Souza; Rone Cardoso; Hebréia O. Almeida-Souza; Camila P. Carvalho; Lucas Ian Veloso Correia; Paula Cristina B. Faria; Galber R. Araujo; Mirian M. Mendes; Renata Santos Rodrigues; Veridiana M. Rodrigues; Abhaya M. Dandekar; Luiz Ricardo Goulart; Rafael Nascimento
- Source:
- International journal of biological macromolecules 2020 v.149 pp. 1241-1251
- ISSN:
- 0141-8130
- Subject:
- neutralizing antibodies, etc ; Bothrops; accidents; antivenoms; coagulants; hemostasis; metalloproteinases; proteolysis; snake bites; snake venoms; toxicity; Brazil; Show all 12 Subjects
- Abstract:
- ... The main systemic alterations present in bothropic envenomation are hemostasis disorders, for which the conventional treatment is based on animal-produced antiophidic sera. We have developed a neutralizing antibody against Bothrops pauloensis (B. pauloensis) venom, which is member of the genus most predominant in snakebite accidents in Brazil. Subsequently, we expressed this antibody in plants to ...
- DOI:
- 10.1016/j.ijbiomac.2020.02.028
- https://doi.org/10.1016/j.ijbiomac.2020.02.028
- Author:
- Alexandra J. Hendry; Frank H. Beard; Aditi Dey; Helen Quinn; Linda Hueston; Dominic E. Dwyer; Peter B. McIntyre
- Source:
- Vaccine 2020 v.38 no.11 pp. 2572-2577
- ISSN:
- 0264-410X
- Subject:
- neutralizing antibodies, etc ; Enterovirus C; blood serum; immunity; seroprevalence; serotypes; travel; vaccines; viruses; young adults; Australia; Show all 11 Subjects
- Abstract:
- ... There are limited long-term data on seroprevalence of neutralising antibody (nAb) to the three poliovirus serotypes following the switch from oral polio vaccine (OPV) to inactivated polio vaccine (IPV). In Australia, combination vaccines containing IPV replaced OPV in late 2005. Using serum and plasma specimens collected during 2012 and 2013, we compared prevalence of nAb to poliovirus type 1 (PV1 ...
- DOI:
- 10.1016/j.vaccine.2020.01.080
- https://doi.org/10.1016/j.vaccine.2020.01.080
- Author:
- Evangelos Terpos; Marianna Politou; Theodoros N. Sergentanis; Andreas Mentis; Margherita Rosati; Dimitris Stellas; Jenifer Bear; Xintao Hu; Barbara K. Felber; Vassiliki Pappa; Maria Pagoni; Elisavet Grouzi; Stavroula Labropoulou; Ioanna Charitaki; Ioannis Ntanasis-Stathopoulos; Dimitra Moschandreou; Anthi Bouhla; Stylianos Saridakis; Eleni Korompoki; Chara Giatra; Tina Bagratuni; Angelos Pefanis; Sotirios Papageorgiou; Alexandros Spyridonidis; Anastasia Antoniadou; Anastasia Kotanidou; Konstantinos Syrigos; Konstantinos Stamoulis; George Panayiotakopoulos; Sotirios Tsiodras; Leonidas Alexopoulos; Meletios A. Dimopoulos; George N. Pavlakis
- Source:
- Microorganisms 2020 v.8 no.12 pp. -
- ISSN:
- 2076-2607
- Subject:
- neutralizing antibodies, etc ; Coronavirus infections; age; antibody formation; antigens; assays; multivariate analysis; nucleocapsid; patients; sampling; testing; viruses; Show all 12 Subjects
- Abstract:
- ... We evaluated the antibody responses in 259 potential convalescent plasma donors for Covid-19 patients. Different assays were used: a commercial ELISA detecting antibodies against the recombinant spike protein (S1); a multiplex assay detecting total and specific antibody isotypes against three SARS-CoV-2 antigens (S1, basic nucleocapsid (N) protein and receptor-binding domain (RBD)); and an in-hous ...
- DOI:
- 10.3390/microorganisms8121885
- https://doi.org/10.3390/microorganisms8121885
- Author:
- Raburn M. Mallory; Andrew Nyborg; Rubana N. Kalyani; Yuan Yuan; Stan L. Block; Filip Dubovsky
- Source:
- Vaccine 2020 v.38 no.5 pp. 1001-1008
- ISSN:
- 0264-410X
- Subject:
- neutralizing antibodies, etc ; children; hemagglutination; immunogenicity; immunoglobulin A; influenza; influenza vaccines; live vaccines; males; nose; Bolivia; Slovenia; Show all 12 Subjects
- Abstract:
- ... Quadrivalent live attenuated influenza vaccine (LAIV4) showed reduced effectiveness against the A/H1N1 component in the 2013–2014 and 2015–2016 influenza seasons. The most likely cause of reduced LAIV effectiveness against A(H1N1)pdm09 strains was poor intranasal replication.To compare the immunogenicity and shedding of a new A/H1N1 strain (A/Slovenia), to a A/H1N1 strain known to have reduced eff ...
- DOI:
- 10.1016/j.vaccine.2019.11.055
- https://doi.org/10.1016/j.vaccine.2019.11.055