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1. A More Granular View of Neutrophils in Malaria

Author:
Amulic, Borko; Moxon, Christopher A.; Cunnington, Aubrey J.
Source:
Trends in parasitology 2020 v.36 no.6 pp. 501-503
ISSN:
1471-4922
Subject:
neutrophils,   etc   ; Plasmodium; immunity; inflammation; malaria; pathogenesis;     Show all 6 Subjects
Abstract:
... Neutrophils are abundant innate immune cells with crucial roles in immunity and vascular inflammation. Recent evidence indicates that neutrophils have a dual role in malaria, contributing to both pathogenesis and control of Plasmodium. We discuss emerging mechanisms behind these opposing functions and identify key outstanding questions. ...
DOI:
10.1016/j.pt.2020.03.003

2. Neodymium-containing contrast induces mummification of neutrophil granulocytes

Author:
Pleskova, Svetlana; Kryukov, Ruslan; Boryakov, Alexey; Gorshkova, Ekaterina
Source:
Environmental pollution 2020 v.258 pp. 113664
ISSN:
0269-7491
Subject:
neutrophils,   etc   ; calcium; cell death; lanthanides; medicine;     Show all 5 Subjects
Abstract:
... Recently, chemical compounds containing lanthanides were used in various fields of biology and medicine. It has been described that such compounds can be applied in scanning electron microscopy (SEM) to increase the contrast and simplify the sample preparation process due to the process of replacing calcium with lanthanides in cell. However cell death by different mechanisms under influence of lan ...
DOI:
10.1016/j.envpol.2019.113664

3. “Cloaking” on Time: A Cover-Up Act by Resident Tissue Macrophages

Author:
Blériot, Camille; Ng, Lai Guan; Ginhoux, Florent
Source:
Cell 2019 v.177 no.3 pp. 514-516
ISSN:
0092-8674
Subject:
neutrophils,   etc   ; macrophages; microscopy;     Show all 3 Subjects
Abstract:
... In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell “macrolesions” are characteristically pro-inflammatory, resident macrophages can “cloak” single-cell microlesions to prevent excessive neutrophil recruitment and limit subsequent tissue d ...
DOI:
10.1016/j.cell.2019.03.042

4. Sialic acid-conjugate modified liposomes targeting neutrophils for improved tumour therapy

Author:
Li, Cong; Qiu, Qiujun; Liu, Min; Liu, Xinrong; Hu, Ling; Luo, Xiang; Lai, Chaoyang; Zhao, Dan; Zhang, Hongxia; Gao, Xin; Deng, Yihui; Song, Yanzhi
Source:
Biomaterials science 2020 v.8 no.8 pp. 2189-2201
ISSN:
2047-4849
Subject:
neutrophils,   etc   ; doxorubicin; drug delivery systems; ligands; mice; neoplasms; sialic acid;     Show all 7 Subjects
Abstract:
... Neutrophils are the most abundant white blood cells in humans. Many tumor-treatment methods that are related to tissue infiltration and the activation of neutrophils have been developed. In particular, one strategy, which aims to improve tumor treatment, involves the exploitation or targeting of activated neutrophils. Peripheral blood neutrophils (PBNs) from tumor-bearing mice display high express ...
DOI:
10.1039/c9bm01732a

5. The Role of Antimicrobial Neutrophil Extract in Modification of the Inflammatory Response During Osteochondral Autograft and Allograft Transplantation in Rabbits

Author:
Wessely-Szponder, J.; Michalska, J.; Szponder, T.; Żylińska, B.; Tarczyńska, M.; Szubstarski, M.
Source:
Journal of comparative pathology 2020 v.175 pp. 49-63
ISSN:
0021-9975
Subject:
neutrophils,   etc   ; allografting; autografting; cartilage; free radicals; inflammation; macrophages; phenotype; rabbits;     Show all 9 Subjects
Abstract:
... Osteochondral autograft or allograft transplantation is one of the surgical options for the management of large cartilage defects; however, the mechanisms of cartilage healing after this procedure, especially the immunological mechanisms, are not fully understood. The present study examined whether a grafting procedure changed the in-vitro responses of neutrophils and monocyte-derived macrophages ...
DOI:
10.1016/j.jcpa.2019.12.007

6. Clinical and histologic tissue responses of skin incisions closed with glycomer 631 and lactomer 9–1 using a subcuticular technique in pigs

Author:
Plavec, Tanja; Švara, Tanja; Zdovc, Irena; Gombač, Mitja; Damjanovska, Marija; Stopar Pintarič, Tatjana; Cvetko, Erika; Seliškar, Alenka
Source:
BMC veterinary research 2020 v.16 no.1 pp. 87
ISSN:
1746-6148
Subject:
neutrophils,   etc   ; Arcanobacterium pyogenes; dehiscence; erythema; fibroblasts; giant cells; histology; inflammation; lymphocytes; macrophages; models; pathogens; swine;     Show all 13 Subjects
Abstract:
... BACKGROUND: Glycomer 631 and lactomer 9–1 are absorbable suture materials indicated for soft tissue approximation in non-infected wounds. Pigs are often used as surgical models in translational research; however, reports of tissue reactions to both suture materials in pigs are limited. The aim of this study was to assess clinical and histologic responses of skin incisions closed with a subcuticula ...
DOI:
10.1186/s12917-020-02290-x
PubMed:
32160877
PubMed Central:
PMC7038600

7. Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities

Author:
Yuan, Kai; Zhu, Qingqing; Lu, Qingyi; Jiang, Haixu; Zhu, Mengmeng; Li, Xiaohong; Huang, Guangrui; Xu, Anlong
Source:
The Journal of nutritional biochemistry 2020 v.84 pp. 108454
ISSN:
0955-2863
Subject:
neutrophils,   etc   ; apoptosis; autophagy; blood plasma; cartilage; chemokines; fruits; inflammation; mice; pathogenesis; quercetin; rheumatoid arthritis; therapeutics; vegetables;     Show all 14 Subjects
Abstract:
... Rheumatoid arthritis (RA) is a prototypical autoimmune disorder mainly characterized by joint inflammation and cartilage destruction. Neutrophils actively take part in the initiation and progression of RA. Neutrophils express inflammatory mediators, including cytokines and chemokines. Aberrant formation of neutrophil extracellular traps (NETs) has been demonstrated in the pathogenesis of RA. Thus, ...
DOI:
10.1016/j.jnutbio.2020.108454

8. Proteome profile of neutrophils from a transgenic diabetic pig model shows distinct changes

Author:
Weigand, Maria; Degroote, Roxane L.; Amann, Barbara; Renner, Simone; Wolf, Eckhard; Hauck, Stefanie M.; Deeg, Cornelia A.
Source:
Journal of proteomics 2020 v.224 pp. 103843
ISSN:
1874-3919
Subject:
neutrophils,   etc   ; animal disease models; diabetes mellitus; human diseases; proteins; proteome; swine; transgenic animals; veterinary medicine;     Show all 9 Subjects
Abstract:
... INSC⁹⁴Y transgenic pigs develop a stable diabetic phenotype early after birth and therefore allow studying the influence of hyperglycemia on primary immune cells in an early stage of diabetes mellitus in vivo. Since immune response is altered in diabetes mellitus, with deviant neutrophil function discussed as one of the possible causes in humans and mouse models, we investigated these immune cells ...
DOI:
10.1016/j.jprot.2020.103843

9. Effects of Hysteroscopic and Uterine Body Insemination on the Presence of Selected Immune Cells in the Equine Endometrium

Author:
Köhne, Martin; Mönnig, Franziska; Papin, Johanna; Schöniger, Sandra; Tönissen, Anna; Rohn, Karl; Martinsson, Gunilla; Schoon, Heinz-Adolf; Sieme, Harald
Source:
Journal of equine veterinary science 2020 v.90 pp. 103023
ISSN:
0737-0806
Subject:
neutrophils,   etc   ; T-lymphocytes; biopsy; cell-mediated immunity; endometrium; immunohistochemistry; insemination; macrophages; mares; microbial contamination; ovulation; spermatozoa;     Show all 12 Subjects
Abstract:
... The effects of standard uterine body and hysteroscopic insemination on endometrial health were investigated. For this purpose, 33 mares were assigned to five different protocols: control (no insemination; n = 7), sham AI (sham uterine body insemination; n = 6), sham HysAI (sham hysteroscopic insemination; n = 7), standard AI (standard uterine body insemination, 300 × 10⁶ progressively motile sperm ...
DOI:
10.1016/j.jevs.2020.103023

10. Differential influence on antibody dependent cellular phagocytosis by different glycoforms on therapeutic Monoclonal antibodies

Author:
Scott, Kuhns; Kuhns, Scott; Shu, Junyan; Xiang, Cathie; Guzman, Ronandro De; Zhang, Qingchun; Bretzlaff, Will; Miscalichi, Nahira; Kalenian, Kevin; Joubert, Marisa
Source:
Journal of biotechnology 2020 v.317 pp. 5-15
ISSN:
0168-1656
Subject:
neutrophils,   etc   ; immunoglobulin G; macrophages; mannose; mechanism of action; monoclonal antibodies; phagocytosis; reporter genes; therapeutics;     Show all 9 Subjects
Abstract:
... Therapeutic monoclonal antibodies (mAbs), particularly of the IgG1 subclass, are capable of effector function activities that may be important for their mechanism of action. One such effector function activity is Antibody Dependent Cellular Phagocytosis (ADCP), which has been shown to be mediated primarily through the activating FcγR, FcγRIIa, on macrophages and neutrophils. The critical quality a ...
DOI:
10.1016/j.jbiotec.2020.04.017

11. Bioactive properties of Acacia dealbata flowers extracts

Author:
Casas, María P.; Conde, Enma; Ribeiro, Daniela; Fernandes, Eduarda; Domínguez, Herminia; Torres, M. D.
Source:
Waste and biomass valorization 2020 v.11 no.6 pp. 2549-2557
ISSN:
1877-2641
Subject:
neutrophils,   etc   ; Acacia dealbata; cytotoxicity; hydrogels; industrial applications; plant extracts; plant residues; solvents;     Show all 8 Subjects
Abstract:
... Floral waste has been considered one of the major concerns, even for those that may have industrial applications, such as dyes or perfumes. In the present study, the possibility of using Acacia dealbata flowers’ extracts and respective fractions as bioactive agents was explored in vitro systems. A. dealbata flowers were extracted with ethanol and the solid residue was further processed with (i) a ...
DOI:
10.1007/s12649-019-00639-4

12. Anti-inflammatory alkaloids from the root bark of Hernandia nymphaeifolia

Author:
Lai, Yu-Wei; Wang, Shih-Wei; Hu, Ya-Yun; Hwang, Tsong-Long; Cheng, Ming-Jen; Chen, Ih-Sheng; Sung, Ping-Jyun; Chen, Jih-Jung
Source:
Phytochemistry 2020 v.173 pp. 112326
ISSN:
0031-9422
Subject:
neutrophils,   etc   ; Hernandia; alkaloids; bark; cytochalasin B; elastase; inhibitory concentration 50; lipopolysaccharides; nitric oxide; spectroscopy; superoxide anion;     Show all 11 Subjects
Abstract:
... Four undescribed alkaloids, 7-ethoxy-6-methoxy-2-methylisoquinolin-1(2H)-one, 7,8-dihydroxy-6-methoxy-2-methylisoquinolin-1(2H)-one, N-formylhernagine, and 5,6-dihydroxy-N-methylphthalimide, were obtained from the root bark of Hernanadia nymphaeifolia, along with fourteen known compounds. The structures of these compounds were determined through spectroscopic and MS analyses. 7,8-Dihydroxy-6-metho ...
DOI:
10.1016/j.phytochem.2020.112326

13. Development of an immunocompetent murine model of pulmonary infection due to Scedosporium apiospermum

Author:
Luna-Rodríguez, Carolina E.; Treviño-Rangel, Rogelio de J.; Soto-Domínguez, Adolfo; Becerril-García, Miguel A.; González-Montalvo, Martin A.; Saldivar M, Andrea M.; Rodríguez-Rocha, Humberto; Gonzalez, Gloria M.
Source:
Microbial pathogenesis 2020 v.142 pp. 104073
ISSN:
0882-4010
Subject:
neutrophils,   etc   ; Scedosporium; animal models; brain; conidia; disease progression; fungi; histopathology; hyphae; kidneys; liver; lungs; mice; spleen;     Show all 14 Subjects
Abstract:
... A pulmonary infection model due to Scedosporium apiospermum in immunocompetent mice was developed. BALB/c mice were infected by endotracheal intubation with 5 × 10⁶ conidia/mouse and disease progression was evaluated on days 1, 3, 5, 7, 11, 16, 21, 30, 50 and 60 post-infection through quantitative culture and histopathological analysis of lungs, livers, spleens, brains, and kidneys. There was no e ...
DOI:
10.1016/j.micpath.2020.104073

14. Extracellular traps (ETosis) can be activated through NADPH-dependent and -independent mechanisms in bivalve mollusks

Author:
Romero, Alejandro; Novoa, Beatriz; Figueras, Antonio
Source:
Developmental and comparative immunology 2020 v.106 pp. 103585
ISSN:
0145-305X
Subject:
neutrophils,   etc   ; DNA; Mytilus galloprovincialis; antimicrobial proteins; chromatin; hemocytes; invertebrates; mammals; microorganisms; models; neutralization; reactive oxygen species;     Show all 12 Subjects
Abstract:
... In mammals, NETosis is a process in which the activation of neutrophils induces the release of chromatin. This DNA prevents the spread of infection by trapping, neutralizing and killing microorganisms during their interaction with antimicrobial proteins. The release of NETs is usually triggered by stimuli that promote reactive oxygen species production. Although this release of extracellular traps ...
DOI:
10.1016/j.dci.2019.103585

15. Treatment of Septic Arthritis With Acoustic Cavitation and Lavage: A Case Report

Author:
Rinnovati, Riccardo; Forni, Giulia; Beltrame, Andrea; Spadari, Alessandro
Source:
Journal of equine veterinary science 2020 v.88 pp. 102945
ISSN:
0737-0806
Subject:
neutrophils,   etc   ; Quarter Horse; acoustics; arthritis; case studies; fillies; protein content; synovial fluid; ultrasonic equipment;     Show all 9 Subjects
Abstract:
... A 2-year-old Quarter Horse filly was admitted to our facility with a two-day history of trauma caused by barbed wire on the front face of the right front limb fetlock joint. A septic arthritis was confirmed with the synovial fluid examination. The cytologic evaluation of synovial fluid showed 101,000 leukocytes/mm³, 90% neutrophils, and a total protein concentration of 4 g/dL. It was, therefore, d ...
DOI:
10.1016/j.jevs.2020.102945

16. Lipid metabolism of leukocytes in the unstimulated and activated states

Author:
Alarcon-Barrera, Juan Carlos; von Hegedus, Johannes H.; Brouwers, Hilde; Steenvoorden, Evelyne; Ioan-Facsinay, Andreea; Mayboroda, Oleg A.; Ondo-Mendez, Alejandro; Giera, Martin
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.10 pp. 2353-2363
ISSN:
1618-2642
Subject:
neutrophils,   etc   ; ceramides; fatty acid composition; lipid metabolism; lymphocytes; monocytes; phosphatidylcholines; polyunsaturated fatty acids; spectroscopy; triacylglycerols;     Show all 10 Subjects
Abstract:
... Lipidomics has emerged as a powerful technique to study cellular lipid metabolism. As the lipidome contains numerous isomeric and isobaric species resulting in a significant overlap between different lipid classes, cutting-edge analytical technology is necessary for a comprehensive analysis of lipid metabolism. Just recently, differential mobility spectrometry (DMS) has evolved as such a technolog ...
DOI:
10.1007/s00216-020-02460-8
PubMed:
32055910
PubMed Central:
PMC7118052

17. Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

Author:
Chiti, L. E.; Martano, M.; Ferrari, R.; Boracchi, P.; Giordano, A.; Grieco, V.; Buracco, P.; Iussich, S.; Giudice, C.; Miniscalco, B.; Zani, D. D.; Proverbio, D.; Morello, E.; Stefanello, D.
Source:
Veterinary and comparative oncology 2020 v.18 no.1 pp. 105-116
ISSN:
1476-5810
Subject:
neutrophils,   etc   ; cats; histology; injection site; lymphocyte count; metastasis; multivariate analysis; patients; retrospective studies; risk; sarcoma; surgery;     Show all 12 Subjects
Abstract:
... Local recurrence (LR) is the major concern in the treatment of feline injection‐site sarcoma (FISS). Pretreatment leukocyte counts and ratios have been reported as diagnostic and/or prognostic markers in human and canine oncology. The aim of this retrospective study was to explore the prognostic impact on LR and overall survival time (OST) of pretreatment neutrophil‐to‐lymphocyte ratio (NLR), whit ...
DOI:
10.1111/vco.12534

18. Interleukin-22 regulates interferon lambda expression in a mice model of pseudomonas aeruginosa pneumonia

Author:
Broquet, Alexis; Besbes, Anissa; Martin, Jérôme; Jacqueline, Cédric; Vourc’h, Mickaël; Roquilly, Antoine; Caillon, Jocelyne; Josien, Régis; Asehnoune, Karim
Source:
Molecular immunology 2020 v.118 pp. 52-59
ISSN:
0161-5890
Subject:
neutrophils,   etc   ; Pseudomonas aeruginosa; animal models; epithelial cells; epithelium; interferons; interleukins; intestines; lungs; neutralization; pneumonia;     Show all 11 Subjects
Abstract:
... Interleukin (IL)-22 is a cytokine involved in tissue protection and repair following lung pathologies. Interferon (IFN)-λ cytokines displayed similar properties during viral infection and a synergy of action between these two players has been documented in the intestine. We hypothesize that during Pseudomonas aeruginosa challenge, IL-22 up-regulates IFN-λ and that IFN-λ exhibits protective functio ...
DOI:
10.1016/j.molimm.2019.12.003

19. Pathological effects of Cichlidogyrus philander Douëllou, 1993 (Monogenea, Ancyrocephalidae) on the gills of Pseudocrenilabrus philander (Weber, 1897) (Cichlidae)

Author:
Igeh, Patience Chwe; Avenant‐Oldewage, Annemariè
Source:
Journal of fish diseases 2020 v.43 no.2 pp. 177-184
ISSN:
0140-7775
Subject:
neutrophils,   etc   ; Cichlidogyrus; Pseudocrenilabrus; blood vessels; epithelial cells; epithelium; erythrocytes; gills; histopathology; hyperplasia;     Show all 10 Subjects
Abstract:
... Histopathological changes of Cichlidogyrus philander Douëllou, 1993 on the gills of Pseudocrenilabrus philander (Weber, 1897) were studied using light and scanning electron microscopy. Observations revealed that C. philander attaches to its host by alternating the prohaptor (for temporary attachment or feeding) or haptor (using haptoral parts for firm and secured attachment). The sharp terminal en ...
DOI:
10.1111/jfd.13121

20. Single cell measurement of calpain activity in neutrophils reveals link to cytosolic Ca2+ elevation and individual phagocytotic events

Author:
Jennings, Samantha; Hallett, Maurice B.
Source:
Biochemical and biophysical research communications 2019 v.515 no.1 pp. 163-168
ISSN:
0006-291X
Subject:
neutrophils,   etc   ; calcium; calpain; fluorescence; phagocytosis; zymosan;     Show all 6 Subjects
Abstract:
... It has been proposed that Ca2+ activation of calpain-1 is important for the rapid cell shape changes which accompany phagocytosis. In this paper, we use a fluorogenic calpain substrate, (CBZ-Ala Ala)2 R110, and find that there was a low calpain activity measureable in resting (ie without intentional activation) neutrophils, but that it was accelerated by an elevation of cytosolic free Ca2+ (ionomy ...
DOI:
10.1016/j.bbrc.2019.05.125