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1. “Cloaking” on Time: A Cover-Up Act by Resident Tissue Macrophages

Author:
Blériot, Camille; Ng, Lai Guan; Ginhoux, Florent
Source:
Cell 2019 v.177 no.3 pp. 514-516
ISSN:
0092-8674
Subject:
neutrophils,   etc   ; macrophages; microscopy;     Show all 3 Subjects
Abstract:
... In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell “macrolesions” are characteristically pro-inflammatory, resident macrophages can “cloak” single-cell microlesions to prevent excessive neutrophil recruitment and limit subsequent tissue d ...
DOI:
10.1016/j.cell.2019.03.042

2. Reproducibility of endometrial cytology using cytobrush technique and agreement for the diagnosis of subclinical endometritis between five predefined endometrial sites

Author:
Pothmann, Harald; Müller, Jessica; Pothmann, Isabella; Tichy, Alexander; Drillich, Marc
Source:
Reproduction in domestic animals 2019 v.54 no.2 pp. 350-357
ISSN:
0936-6768
Subject:
neutrophils,   etc   ; dairy cows; endometritis; endometrium; probability;     Show all 5 Subjects
Abstract:
... The objectives of this study were as follows: (a) to assess the reproducibility of polymorphonuclear neutrophil (PMN) cell counts at five predefined endometrial sites (corpus uteri, left horn base, right horn base, left horn tip and right horn tip) and (b) to determine the agreement for the diagnosis of subclinical endometritis (SE) between the different endometrial sites. Forty milking cows betwe ...
DOI:
10.1111/rda.13367

3. Defective rapid cell shape and transendothelial migration by calpain-1 null neutrophils

Author:
Ishak, Reezal; Hallett, Maurice B.
Source:
Biochemical and biophysical research communications 2018 v.506 no.4 pp. 1065-1070
ISSN:
0006-291X
Subject:
neutrophils,   etc   ; calcium; chemotaxis; mice;     Show all 4 Subjects
Abstract:
... It has been proposed that Ca2+ activation of calpain-1 is an important trigger for rapid cell spreading by neutrophils. In this paper, we have investigated this by assessing the ex vivo functioning of neutrophils from calpain-1 null mice, Calpain-1 null neutrophils failed to migrate through TNF-activated endothelial monolayers. The failure to transmigrate through endothelial monolayers was therefo ...
DOI:
10.1016/j.bbrc.2018.10.174

4. Neutrophils: Homing in on the myeloid mechanisms of metastasis

Author:
Leach, Joshua; Morton, Jennifer P.; Sansom, Owen J.
Source:
Molecular immunology 2019 v.110 pp. 69-76
ISSN:
0161-5890
Subject:
neutrophils,   etc   ; lymphocytes; macrophages; metastasis; neoplasm cells; neoplasms; stromal cells;     Show all 7 Subjects
Abstract:
... The metastasis cascade is complex and comprises several stages including local invasion into surrounding tissue, intravasation and survival of tumour cells in the circulation, and extravasation and colonisation of a distant site. It is increasingly clear that these processes are driven not only by signals within the tumour cells, but are also profoundly influenced by stromal cells and signals in t ...
DOI:
10.1016/j.molimm.2017.12.013

5. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

Author:
Uderhardt, Stefan; Martins, Andrew J.; Tsang, John S.; Lämmermann, Tim; Germain, Ronald N.
Source:
Cell 2019 v.177 no.3 pp. 541-555.e17
ISSN:
0092-8674
Subject:
neutrophils,   etc   ; cell death; chemoattractants; homeostasis; image analysis; macrophages; microscopy; tissues;     Show all 8 Subjects
Abstract:
... Neutrophils are attracted to and generate dense swarms at sites of cell damage in diverse tissues, often extending the local disruption of organ architecture produced by the initial insult. Whether the inflammatory damage resulting from such neutrophil accumulation is an inescapable consequence of parenchymal cell death has not been explored. Using a combination of dynamic intravital imaging and c ...
DOI:
10.1016/j.cell.2019.02.028

6. Contribution of lung function tests to the staging of severe equine asthma syndrome in the field

Author:
Simões, Joana; Sales Luís, José; Tilley, Paula
Source:
Research in veterinary science 2019 v.123 pp. 112-117
ISSN:
0034-5288
Subject:
neutrophils,   etc   ; asthma; discriminant analysis; histamine; horses; lung function; models;     Show all 7 Subjects
Abstract:
... Staging methods are useful tools for monitoring disease and response to treatment, and because Severe Equine Asthma Syndrome (SEAS) has a high prevalence in the equine population, a clinical staging method can provide important information to optimize equine care.Our team has previously developed and published a clinical staging method for SEAS and in the present study we further evaluated informa ...
DOI:
10.1016/j.rvsc.2018.12.014

7. Influence of Type of Use, Age and Gender on Haematological and Biochemical Blood Parameters of Małopolski Horses

Author:
Czech, Anna; Kiesz, Martyna; Kiesz, Adrian; Próchniak, Tomasz; Różański, Paweł; Klimiuk, Kamila
Source:
Annals of animal science 2019 v.19 no.1 pp. 85-96
ISSN:
2300-8733
Subject:
neutrophils,   etc   ; bone formation; calcium; erythrocytes; exercise; mares; phosphorus; sports; stallions;     Show all 9 Subjects
Abstract:
... The purpose of the study was to determine whether the type of use, age and gender of Małopolski horses affect the level of selected haematological and biochemical parameters of their blood and whether there is an interaction between these factors. The research was carried out on 30 horses of the Małopolski breed, which were divided according to gender (18 mares and 12 stallions), age (2–6 years, 7 ...
DOI:
10.2478/aoas-2018-0031

8. White Blood Cell Count of the Bullhead Notothen Notothenia coriiceps during the Annual Cycle

Author:
Basova, M. M.
Source:
Journal of ichthyology 2018 v.58 no.5 pp. 757-760
ISSN:
0032-9452
Subject:
neutrophils,   etc   ; Notothenia coriiceps; islands; leukocyte count; spawning;     Show all 5 Subjects
Abstract:
... The report outlines the research findings on White Blood Cell Count during the annual cycle of the bullhead notothen Notothenia coriiceps native to waters of Galindez Island (the Argentine Islands). We found a statistically significant reduction in lymphocyte concentration and an increase in the proportion of segmented neutrophils during the spawning season. ...
DOI:
10.1134/S003294521805003X

9. Neutrophils in tissue injury and repair

Author:
Wang, Jing
Source:
Cell and tissue research 2018 v.371 no.3 pp. 531-539
ISSN:
0302-766X
Subject:
neutrophils,   etc   ; homeostasis; innate immunity; plasticity; tissue repair;     Show all 5 Subjects
Abstract:
... As one of the first defenders of innate immune response, neutrophils make a rapid and robust response against infection or harmful agents. While traditionally regarded as suicidal killers that cause collateral tissue damage, recent findings on neutrophil extracellular trap formation, heterogeneity and plasticity and novel reparative functions have expanded our understanding of their diverse roles ...
DOI:
10.1007/s00441-017-2785-7
PubMed:
29383445
PubMed Central:
PMC5820392

10. Neutrophils in viral infection

Author:
Naumenko, Victor; Turk, Madison; Jenne, CraigN.; Kim, Seok-Joo
Source:
Cell and tissue research 2018 v.371 no.3 pp. 505-516
ISSN:
0302-766X
Subject:
neutrophils,   etc   ; cytokines; fungi; immunity; neoplasms; pathogenesis; viruses;     Show all 7 Subjects
Abstract:
... Neutrophils are the first wave of recruited immune cells to sites of injury or infection and are crucial players in controlling bacterial and fungal infections. Although the role of neutrophils during bacterial or fungal infections is well understood, their impact on antiviral immunity is much less studied. Furthermore, neutrophil function in tumor pathogenesis and cancer treatment has recently re ...
DOI:
10.1007/s00441-017-2763-0

11. Platelet–neutrophil interactions as drivers of inflammatory and thrombotic disease

Author:
Lisman, Ton
Source:
Cell and tissue research 2018 v.371 no.3 pp. 567-576
ISSN:
0302-766X
Subject:
neutrophils,   etc   ; atherosclerosis; blood platelets; hemostasis; inflammation; thrombosis;     Show all 6 Subjects
Abstract:
... Neutrophils are well known for their role in infection and inflammatory disease and are first responders at sites of infection or injury. Platelets have an established role in hemostasis and thrombosis and are first responders at sites of vascular damage. However, neutrophils are increasingly recognized for their role in thrombosis, while the immunemodulatory properties of platelets are being incr ...
DOI:
10.1007/s00441-017-2727-4
PubMed:
29178039
PubMed Central:
PMC5820397

12. Candidalysin: discovery and function in Candida albicans infections

Author:
Naglik, Julian R; Gaffen, Sarah L; Hube, Bernhard
Source:
Current opinion in microbiology 2019 v.52 pp. 100-109
ISSN:
1369-5274
Subject:
neutrophils,   etc   ; Candida albicans; animal pathogenic fungi; candidiasis; immune response; pathogenesis; peptides; virulence;     Show all 8 Subjects
Abstract:
... Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune respon ...
DOI:
10.1016/j.mib.2019.06.002

13. Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease

Author:
Oh, Gabriel; Koncevičius, Karolis; Ebrahimi, Sasha; Carlucci, Matthew; Groot, Daniel Erik; Nair, Akhil; Zhang, Aiping; Kriščiūnas, Algimantas; Oh, Edward S.; Labrie, Viviane; Wong, Albert H. C.; Gordevičius, Juozas; Jia, Peixin; Susic, Miki; Petronis, Art
Source:
Genome biology 2019 v.20 no.1 pp. 2
ISSN:
1474-760X
Subject:
neutrophils,   etc   ; DNA methylation; circadian rhythm; cytosine; demethylation; epigenetics; genes; human health; humans; mice; risk;     Show all 11 Subjects
Abstract:
... BACKGROUND: Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases. RESULTS: Extending our recent findings of oscillating cytosine modifications (osc-modCs) in mice, in this study, we show that osc-modCs are also prevalent in human ...
DOI:
10.1186/s13059-018-1608-9

14. Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection

Author:
Wei, Furong; Gong, Wenci; Wang, Junyun; Yang, Yuetao; Liu, Jianxiu; Wang, Yanjuan; Cao, Jianping
Source:
Parasites & vectors 2019 v.12 no.1 pp. 275
ISSN:
1756-3305
Subject:
neutrophils,   etc   ; Leishmania infantum; antagonists; extrusion; histones; inflammation; leishmaniasis; mechanism of action; promastigotes; therapeutics;     Show all 10 Subjects
Abstract:
... BACKGROUND: Neutrophils play an immunomodulatory role through the release of neutrophil extracellular traps (NETs). NETs are released in response to Leishmania infection, but the mechanism of NET extrusion has not been elucidated. The lipoxin A4 receptor on neutrophils is crucial for the inflammatory response and immune regulation of many diseases, including Leishmania infection. Therefore, in the ...
DOI:
10.1186/s13071-019-3530-8

15. A versatile high-throughput assay to characterize antibody-mediated neutrophil phagocytosis

Author:
Karsten, Christina B.; Mehta, Nickita; Shin, Sally A.; Diefenbach, Thomas J.; Slein, Matthew D.; Karpinski, Wiktor; Irvine, Edward B.; Broge, Thomas; Suscovich, Todd J.; Alter, Galit
Source:
Journal of immunological methods 2019 v.471 pp. 46-56
ISSN:
0022-1759
Subject:
neutrophils,   etc   ; antibodies; antigens; blood serum; enzymes; flow cytometry; immunologic receptors; immunomodulators; phagocytosis; secretion;     Show all 10 Subjects
Abstract:
... Neutrophils, the most abundant white blood cell, play a critical role in anti-pathogen immunity via phagocytic clearance, secretion of enzymes and immunomodulators, and the release of extracellular traps. Neutrophils non-specifically sense infection through an array of innate immune receptors and inflammatory sensors, but are also able to respond in a pathogen/antigen-specific manner when leverage ...
DOI:
10.1016/j.jim.2019.05.006

16. Cytological Findings in Bronchoalveolar Lavage Fluid of Foals With Pneumonia Caused by Rhodococcus equi and Other Bacteria

Author:
Vitale, Valentina; Sgorbini, Micaela; Cuteri, Vincenzo; Preziuso, Silvia; Attili, Anna Rita; Bonelli, Francesca
Source:
Journal of equine veterinary science 2019 v.79 pp. 9-12
ISSN:
0737-0806
Subject:
neutrophils,   etc   ; Rhodococcus equi; bacteria; bacterial pneumonia; bronchopneumonia; databases; equipment; foals; hospitals; macrophages; pathogens; retrospective studies;     Show all 12 Subjects
Abstract:
... The distinction between lower respiratory tract infections caused by Rhodococcus equi and those caused by other pathogens is difficult. The aim of this retrospective study was to describe cytological findings in bronchoalveolar lavage fluid (BALF) of foals with pneumonia caused by R. equi or other bacteria. Nineteen foals aged from 3 weeks to 6 months with evidence of respiratory disease between 2 ...
DOI:
10.1016/j.jevs.2019.05.009

17. Transient receptor potential vanilloid 4 is a critical mediator in LPS mediated inflammation by mediating calcineurin/NFATc3 signaling

Author:
Li, Min; Fang, Xiang-Zhi; Zheng, Yong-Feng; Xie, Yun-Bin; Ma, Xiao-Dong; Liu, Xiao-Tian; Xia, Yan; Shao, Dong-Hua
Source:
Biochemical and biophysical research communications 2019 v.513 no.4 pp. 1005-1012
ISSN:
0006-291X
Subject:
neutrophils,   etc   ; calcium; culture media; cyclosporine; cytokines; inflammation; lungs; macrophage activation; macrophages; transient receptor potential vanilloid channels;     Show all 10 Subjects
Abstract:
... Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel is thought to be an essential component of inflammatory response. However, its role and mechanism in regulating acute lung injury (ALI) and macrophages activation are not well characterized. In our study, we observe that blockade of TRPV4 using GSK2193874 or HC-067047 greatly improve the pneumonedema, the lung pathologic changes, the up- ...
DOI:
10.1016/j.bbrc.2019.04.020

18. Neutrophil pyroptosis: new perspectives on sepsis

Author:
Liu, Lu; Sun, Bingwei
Source:
Cellular and molecular life sciences 2019 v.76 no.11 pp. 2031-2042
ISSN:
1420-682X
Subject:
neutrophils,   etc   ; active immunity; caspase-1; inflammasomes; inflammation; innate immunity; pathogens; programmed cell death; sepsis (infection);     Show all 9 Subjects
Abstract:
... Pyroptosis is a caspase-1 or caspase-4/5/11-dependent programmed cell death associated with inflammation, which is initiated by inflammasomes or cytosolic LPS in innate immunity. Sepsis is a life-threatening organ dysfunction caused by an imbalance in the body’s response to infection. It is a complex interaction between the pathogen and the host’s immune system. Neutrophils play the role of a doub ...
DOI:
10.1007/s00018-019-03060-1

19. Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55

Author:
Gifford, Geoffrey; Vu, Vivian P.; Banda, Nirmal K.; Holers, V. Michael; Wang, Guankui; Groman, Ernest V.; Backos, Donald; Scheinman, Robert; Moghimi, S. Moein; Simberg, Dmitri
Source:
Journal of controlled release 2019 v.302 pp. 181-189
ISSN:
0168-3659
Subject:
neutrophils,   etc   ; complement; engineering; humans; inhibitory concentration 50; intravenous injection; lectins; models; monocytes; nanomedicine; nanoparticles; pharmacokinetics; therapeutics;     Show all 13 Subjects
Abstract:
... Complement activation plays an important role in pharmacokinetic and performance of intravenously administered nanomedicines. Significant efforts have been directed toward engineering of nanosurfaces with low complement activation, but due to promiscuity of complement factors and redundancy of pathways, it is still a major challenge. Cell membrane-anchored Decay Accelerating Factor (DAF, a.k.a. CD ...
DOI:
10.1016/j.jconrel.2019.04.009

20. Unravelling the lipocalin 2 interaction with aptamers: May rolling circle amplification improve their functional affinity?

Author:
Lorenzo-Gómez, Ramón; Fernández-Alonso, Noelia; Miranda-Castro, Rebeca; de-los-Santos-Álvarez, Noemí; Lobo-Castañón, María Jesús
Source:
Talanta 2019 v.197 pp. 406-412
ISSN:
0039-9140
Subject:
neutrophils,   etc   ; biomarkers; blood serum; chemical bonding; electrochemistry; electrodes; gold; magnetism; neoplasms; oligonucleotides; receptors;     Show all 11 Subjects
Abstract:
... Cancer diagnosis based on serum biomarkers requires receptors of extreme sensitivity and selectivity. Tunability of aptamer selection makes them ideal for that challenge. However, aptamer characterization is a time-consuming task, not always thoroughly addressed, leading to suboptimal aptamer performance. In this work, we report on the affinity characterization and potential usage of two aptamers ...
DOI:
10.1016/j.talanta.2019.01.057