U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject "neutrophils" Remove constraint Subject: "neutrophils"
Start Over

Search

7,342  Search Results

« Previous | 1 - 20 of 7,342 |
Number of results to display per page

Search Results

1. Analytical variability and uncertainty in canine leukocyte ratios obtained with manual counts

Author:
Pierangelo Moretti; Roberta Franchi; Teresa Maria Poluzzi; Saverio Paltrinieri
Source:
Veterinary record 2022 v.191 no.1 pp. e1628
ISSN:
0042-4900
Subject:
neutrophils,   etc   ; dogs; monocytes; uncertainty;     Show all 4 Subjects
Abstract:
... BACKGROUND: This study aimed to determine the analytical imprecision of calculated neutrophil to lymphocyte (NLR) and lymphocyte to monocyte ratios generated from manual differential white blood cell (WBC) counts in peripheral blood smears, and to describe how to report the uncertainty around a single WBC ratio result. No information on the analytical imprecision of WBC ratios in dogs is available ...
DOI:
10.1002/vetr.1628

2. A specific esterase and pH logically regulate ESIPT: different kinds of granulocyte sorting

Author:
Kui Wang; Beidou Feng; Ge Wang; Jingqiang Cui; Lin Yang; Kai Jiang; Hua Zhang
Source:
Chemical communications 2022 v.58 no.17 pp. 2894-2897
ISSN:
1364-548X
Subject:
neutrophils,   etc   ; esterases; fluorescence; pH;     Show all 4 Subjects
Abstract:
... Simultaneously detecting naphthol AS-D chloroacetate esterase (NAS-DCE) and pH is an effective way to separate different granulocytes, which is of great significance for the analysis of blood. A series of fluorescent small molecules (HBT-ASDs) were designed, whose ESIPT process could be logically regulated by NAS-DCE and pH. One typical molecule, HBT-ASD-2, emits three kinds of fluorescence output ...
DOI:
10.1039/d1cc07261g

3. Quo vadis, neutrophil?

Author:
Rodrigo J. Gonzalez; Ulrich H. von Andrian
Source:
Cell 2022 v.185 no.5 pp. 759-761
ISSN:
0092-8674
Subject:
neutrophils,   etc   ; inflammation; metabolites; serotonin;     Show all 4 Subjects
Abstract:
... Neutrophil recruitment from blood into tissues is a hallmark of inflammation and anti-microbial host defense. In this issue, De Giovanni et al. describe an unanticipated role for a serotonin metabolite, 5-HIAA, which is produced by activated platelets and mast cells and engages the orphan receptor, GPR35, to recruit neutrophils to inflamed tissues. ...
DOI:
10.1016/j.cell.2022.02.009

4. Opportunities presented by zebrafish larval models to study neutrophil function in tissues

Author:
Henna Myllymäki; Peiyi (Pearl) Yu; Yi Feng
Source:
international journal of biochemistry & cell biology 2022 v.148 pp. 106234
ISSN:
1357-2725
Subject:
neutrophils,   etc   ; Danio rerio; biochemistry; models;     Show all 4 Subjects
Abstract:
... Appropriate neutrophil function is essential for innate immune defence and to avoid inflammatory pathology. Neutrophils can adapt their responses according to their environment and recently, the existence of multiple distinct neutrophil populations has been confirmed in both health and disease. However, the study of neutrophil functions in their tissue environment has remained challenging, and for ...
DOI:
10.1016/j.biocel.2022.106234

5. The role of neutrophils in antibody-driven autoimmune cytopenias

Author:
Vanessa Krémer; Luc de Chaisemartin; Friederike Jönsson
Source:
international journal of biochemistry & cell biology 2022 v.147 pp. 106231
ISSN:
1357-2725
Subject:
neutrophils,   etc   ; autoantibodies; complement; macrophages; monocytes; phagocytosis;     Show all 6 Subjects
Abstract:
... Autoimmune cytopenias are a consequence of autoantibodies that target blood cell lineages and mark them for their accelerated destruction, mostly through phagocytosis by monocytes and macrophages and complement activation. Neutrophils, although equipped with Fc and complement receptors and effector mechanisms that are critical in other autoimmune conditions, remained long overlooked. Recent report ...
DOI:
10.1016/j.biocel.2022.106231

6. Extracellular vesicles derived from mesenchymal stromal cells as nanotherapeutics for liver ischaemia–reperfusion injury by transferring mitochondria to modulate the formation of neutrophil extracellular traps

Author:
Tongyu Lu; Jiebin Zhang; Jianye Cai; Jiaqi Xiao; Xin Sui; Xiaofeng Yuan; Rong Li; Yang Li; Jia Yao; Guo Lv; Xiaoyan Chen; Haitian Chen; Kaining Zeng; Yasong Liu; Wenjie Chen; Guihua Chen; Yang Yang; Jun Zheng; Yingcai Zhang
Source:
Biomaterials 2022 v.284 pp. 121486
ISSN:
0142-9612
Subject:
neutrophils,   etc   ; biocompatible materials; humans; liver; mitochondria; therapeutics;     Show all 6 Subjects
Abstract:
... As nanotherapeutics, mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are considered a potent alternative for whole-cell therapy and are gradually entering the clinical field of liver diseases. In this study, neutrophil extracellular traps (NETs) formation in liver tissue was verified as a critical factor for liver ischaemia–reperfusion injury (IRI) in both clinical samples and an ...
DOI:
10.1016/j.biomaterials.2022.121486

7. The non-cardiovascular actions of ACE

Author:
DuoYao Cao; Luciana Veiras; Faizan Ahmed; Tomohiro Shibata; Ellen A. Bernstein; Derick Okwan-Duodu; Jorge F. Giani; Zakir Khan; Kenneth E. Bernstein
Source:
Peptides 2022 v.152 pp. 170769
ISSN:
0196-9781
Subject:
neutrophils,   etc   ; aerobiosis; atherosclerosis; hypertension; immune response; macrophages;     Show all 6 Subjects
Abstract:
... Angiotensin converting enzyme (ACE) is well known for its role producing the vasoconstrictor angiotensin II and ACE inhibitors are commonly used for treating hypertension and cardiovascular disease. However, ACE has many different substrates besides angiotensin I and plays a role in many different physiologic processes. Here, we discuss the role of ACE in the immune response. Several studies in mi ...
DOI:
10.1016/j.peptides.2022.170769

8. Relationship between transport-induced stress and the expression levels of some genes in the peroxisome proliferator-activated receptor (PPAR) signaling pathway in Kivircik lambs

Author:
Korhan Arslan; Fadime Daldaban; Pembe Dilara Kecici; Esma Gamze Aksel; Bulent Ekiz; Bilal Akyuz; Alper Yilmaz; Aytac Akcay; Kaan Iscan
Source:
Small ruminant research 2022 v.212 pp. 106708
ISSN:
0921-4488
Subject:
neutrophils,   etc   ; gene expression; genes; glucose; meat quality; research;     Show all 6 Subjects
Abstract:
... This study investigated the relationship between expression levels of SCD, LPL PPARα, PPARγ and PCK2 genes in the PPAR signaling pathway and blood stress parameters and meat quality in Kivircik lambs. Two trial groups were formed from 4 to 5-month-old lambs, by 0.2 m²/lamb and 0.3 m²/lamb stocking density during transport. The differences between the groups in terms of neutrophil: leukocyte and gl ...
DOI:
10.1016/j.smallrumres.2022.106708

9. Two New Prenylated 2-Arylbenzofurans from Artocarpus nanchuanensis and Their Antirespiratory Burst Activities

Author:
Jing Yan; Ryan Sun
Source:
Chemistry of natural compounds 2022 v.58 no.3 pp. 442-445
ISSN:
0009-3130
Subject:
neutrophils,   etc   ; Artocarpus; chemistry; models; rats; respiratory burst; spectroscopy;     Show all 7 Subjects
Abstract:
... Two new prenylated 2-arylbenzofurans, namely artonancins A and B (1 and 2), together with four known ones (3–6), were isolated from the roots of Artocarpus nanchuanensis S. S. Chang for the first time. Their structures were determined by spectroscopic methods. Compounds 1–6 were evaluated for the antirespiratory burst properties using a cellular model reproduced by chemical stimulation of rat neut ...
DOI:
10.1007/s10600-022-03705-x

10. Composition of Peripheral Blood Leukocytes of Pink Salmon Oncorhynchus gorbuscha and Chum Salmon O. keta (Salmonidae) during the Marine Life Period [Erratum: June 2022, v.62(3); p.518]

Author:
I. I. Gordeev; L. V. Balabanova; T. A. Suvorova; D. V. Mikryakov
Source:
Journal of ichthyology 2022 v.62 no.2 pp. 322-326
ISSN:
0032-9452
Subject:
neutrophils,   etc   ; Oncorhynchus gorbuscha; Oncorhynchus keta; eosinophils; ichthyology; monocytes;     Show all 6 Subjects
Abstract:
... In pink salmon Onchorhynchus gorbuscha and chum salmon O. keta lymphocytes predominate among leukocytes in the peripheral blood during the marine period of life. In both species eosinophils are absent, while in pink salmon basophils are also absent. The proportion of segmented neutrophils and the size of lymphocytes, monocytes, and stab neutrophils are lower in chum salmon than in pink salmon. ...
DOI:
10.1134/S0032945222020060

11. Neutrophil infiltration in co-housed littermates plays a key role in nasal transmission of Streptococcus pneumoniae in an infant mouse model

Author:
Fumie Kaneko; Masamitsu Kono; Hiroshi Sunose; Muneki Hotomi
Source:
Folia microbiologica 2022 v.67 no.1 pp. 45-54
ISSN:
0015-5632
Subject:
neutrophils,   etc   ; Streptococcus pneumoniae; inflammation; macrophages; mice; nasal mucosa;     Show all 6 Subjects
Abstract:
... Transmission plays an important role in establishing pneumococcal colonization. It comprises three key events: shedding to transmit, entering into a susceptible new host, and adhering to the mucosal surface. Shedding of pneumococci from the respiratory tract of a colonized host is a pivotal step in transmission. Using a co-housed littermate mouse model, we evaluated the importance of the susceptib ...
DOI:
10.1007/s12223-021-00901-0

12. Detection of frequent neutrophil misclassification by the ProCyte Dx in sick dogs and how to avoid it

Author:
E. Bergstrand; H. W. Tvedten; I. Lilliehöök
Source:
journal of small animal practice 2022 v.63 no.8 pp. 603-608
ISSN:
0022-4510
Subject:
neutrophils,   etc   ; cats; dogs; hospitals; inflammation; monocytes; small animal practice;     Show all 7 Subjects
Abstract:
... OBJECTIVES: A common and severe error in identifying neutrophils in feline blood samples by the IDEXX ProCyte Dx haematology analyser (ProCyte) has been reported. The hypothesis was that the same or similar error would be identified during analysis of canine blood samples and that white blood cell dot plot evaluation would be critical to detect and avoid erroneous results. MATERIALS AND METHODS: E ...
DOI:
10.1111/jsap.13499

13. Gut microbiota aggravate cardiac ischemia-reperfusion injury via regulating the formation of neutrophils extracellular traps

Author:
Chunxia Chen; Hao Zhang; Ran Xie; Yaohui Wang; Yuanfang Ma
Source:
Life sciences 2022 v.303 pp. 120670
ISSN:
0024-3205
Subject:
neutrophils,   etc   ; apoptosis; death; intestinal microorganisms; models; mortality; myocardial infarction;     Show all 7 Subjects
Abstract:
... Myocardial infarction (MI) is a leading cause of death worldwide for which there is no cure. Percutaneous coronary intervention (PCI) can restore blood supply in a timely manner, which greatly reduces the mortality of patients, but ischemia/reperfusion (I/R) injury is inevitable. A number of clinical studies have shown that gut microbiota play an essential role in cardiovascular diseases. This stu ...
DOI:
10.1016/j.lfs.2022.120670

14. Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases

Author:
Chao Chen; Heqi Gao; Hanlin Ou; Ryan T. K. Kwok; Youhong Tang; Donghui Zheng; Dan Ding
Source:
Journal of the American Chemical Society 2022 v.144 no.8 pp. 3429-3441
ISSN:
1520-5126
Subject:
neutrophils,   etc   ; acidification; animals; cell death; geometry; hypersensitivity; inflammation; luminescence; pH;     Show all 9 Subjects
Abstract:
... Understanding the mechanism and progression of neutrophil-involved diseases (e.g., acute inflammation) is of great importance. However, current available analytical methods neither achieve the real-time monitoring nor provide dynamic information during the pathological processes. Herein, a peroxynitrite (ONOO–) and environmental pH dual-responsive afterglow luminescent nanoprobe is designed and sy ...
DOI:
10.1021/jacs.1c11455

15. Microscopical Evaluation of Smears of the Leptomeninges to Predict Meningitis in Piglets

Author:
Marc Schyns; Dominiek Maes; Wikke Kuller; Erik Weerts
Source:
Veterinary sciences 2022 v.9 no.7 pp. -
ISSN:
2306-7381
Subject:
neutrophils,   etc   ; Streptococcus; bacterial culture; brain; death; dyes; meningitis; mortality; necropsy;     Show all 9 Subjects
Abstract:
... Meningitis, caused by bacterial infections such as Streptococcus spp., is a frequently observed cause of death in pigs. In order to implement effective treatment and avoid further losses, it is important to establish this diagnosis quickly. However, this is often difficult because macroscopic lesions may not be visible, and additional laboratory testing may take several days. The present study inv ...
DOI:
10.3390/vetsci9070341

16. Urinary Cytology: Potential Role in Canine Urinary Tract Infections

Author:
Ilaria Lippi; Verena Habermaass; Eleonora Gori; Valentina Virginia Ebani; Alessio Pierini; Veronica Marchetti
Source:
Veterinary sciences 2022 v.9 no.6 pp. -
ISSN:
2306-7381
Subject:
neutrophils,   etc   ; antibiotics; dogs; inflammation; plate count; sediments; urinary tract; urine;     Show all 8 Subjects
Abstract:
... The diagnosis of urinary tract infections (UTIs) requires a concomitant evaluation of clinical signs and urine culture, which is of fundamental to start an appropriate antibiotic treatment. Several factors, such as subclinical bacteriuria or pre-analytical errors, may make the interpretation of urine culture difficult. The aim of the study was to evaluate the association between the finding of neu ...
DOI:
10.3390/vetsci9060304

17. Structural insights into the activation of chemokine receptor CXCR2

Author:
Kaiwen Liu; Ling Shen; Meng Wu; Zhi‐Jie Liu; Tian Hua
Source:
FEBS journal 2022 v.289 no.2 pp. 386-393
ISSN:
1742-464X
Subject:
neutrophils,   etc   ; antagonists; cholesterol; cryo-electron microscopy; crystal structure; interleukin-8;     Show all 6 Subjects
Abstract:
... The C‐X‐C motif chemokine CXCL8 (interleukin‐8, IL‐8) and its receptor chemokine receptor 2 (CXCR2) mediate neutrophil migration during cell development and inflammatory responses and thus are related to numerous inflammatory diseases and cancers. We have determined the cryo‐electron microscopy structure of CXCL8 bound CXCR2 coupled to Gᵢ protein, as well as the crystal structure of inactive CXCR2 ...
DOI:
10.1111/febs.15865

18. Neutrophil membrane-coated immunomagnetic nanoparticles for efficient isolation and analysis of circulating tumor cells

Author:
Xianjia Wu; Zhousheng Lin; Chenchen Zhao; Lujie Liu; Kelin Zhang; Jialin Lai; Qian-Fang Meng; Gaungyu Yao; Qinqin Huang; Xing-Zhong Zhao; Lang Rao
Source:
Biosensors & bioelectronics 2022 v.213 pp. 114425
ISSN:
0956-5663
Subject:
neutrophils,   etc   ; adsorption; biosensors; breast neoplasms; early diagnosis; ligands; precision medicine; viability;     Show all 8 Subjects
Abstract:
... The isolation and analysis of scarce circulating tumor cells (CTCs) with immunomagnetic nanoparticles (IMNs) have shown promising outcomes in noninvasive cancer diagnosis. However, the IMNs adsorb nonspecific proteins after entering into biofluids and the formed protein coronas cover surface targeting ligands, limiting the detection efficiency of IMNs. In addition, the interaction between surface ...
DOI:
10.1016/j.bios.2022.114425

19. Neutrophil to lymphocyte ratio as a prognostic biomarker in puppies with acute diarrhea

Author:
Ceren Dinler Ay
Source:
Journal of veterinary emergency and critical care 2022 v.32 no.1 pp. 83-89
ISSN:
1479-3261
Subject:
neutrophils,   etc   ; biomarkers; clinical examination; diarrhea; disease severity; hospitals; inflammation; retrospective studies;     Show all 8 Subjects
Abstract:
... OBJECTIVES: To document the neutrophil to lymphocyte ratio (NLR) values in systemic inflammatory response syndrome positive (SIRS+) and negative (SIRS–) puppies presenting with acute diarrhea (AD). To determine whether the calculated canine acute diarrhea severity index (CADSI) score was associated with NLR. Also, to investigate the prognostic value of NLR in puppies with acute diarrhea. DESIGN: R ...
DOI:
10.1111/vec.13159

20. Targeted downregulation of HIF-1α for restraining circulating tumor microemboli mediated metastasis

Author:
Junjie Du; Cong Wang; Yijun Chen; Lingyu Zhong; Xuwentai Liu; Lingjing Xue; Ying Zhang; Yanyi Li; Xiaoyu Li; Chunming Tang; Zhigui Su; Can Zhang
Source:
Journal of controlled release 2022 v.343 pp. 457-468
ISSN:
0168-3659
Subject:
neutrophils,   etc   ; blood flow; hypoxia; immune response; lungs; metastasis; mortality; neoplasms; prognosis;     Show all 9 Subjects
Abstract:
... Tumor metastasis is directly correlated to poor prognosis and high mortality. Circulating tumor cells (CTCs) play a pivotal role in metastatic cascades, of which CTC clusters is highly metastatic compared to single CTCs. Although platelets and neutrophils within the bloodstream could further exacerbate the pro-metastatic effect of single CTCs, the influence of platelets and neutrophils on CTC clus ...
DOI:
10.1016/j.jconrel.2022.01.051