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... BACKGROUND: This study aimed to determine the analytical imprecision of calculated neutrophil to lymphocyte (NLR) and lymphocyte to monocyte ratios generated from manual differential white blood cell (WBC) counts in peripheral blood smears, and to describe how to report the uncertainty around a single WBC ratio result. No information on the analytical imprecision of WBC ratios in dogs is available ...
... Simultaneously detecting naphthol AS-D chloroacetate esterase (NAS-DCE) and pH is an effective way to separate different granulocytes, which is of great significance for the analysis of blood. A series of fluorescent small molecules (HBT-ASDs) were designed, whose ESIPT process could be logically regulated by NAS-DCE and pH. One typical molecule, HBT-ASD-2, emits three kinds of fluorescence output ...
neutrophils, etc ; inflammation; metabolites; serotonin; Show all 4 Subjects
Abstract:
... Neutrophil recruitment from blood into tissues is a hallmark of inflammation and anti-microbial host defense. In this issue, De Giovanni et al. describe an unanticipated role for a serotonin metabolite, 5-HIAA, which is produced by activated platelets and mast cells and engages the orphan receptor, GPR35, to recruit neutrophils to inflamed tissues. ...
... Appropriate neutrophil function is essential for innate immune defence and to avoid inflammatory pathology. Neutrophils can adapt their responses according to their environment and recently, the existence of multiple distinct neutrophil populations has been confirmed in both health and disease. However, the study of neutrophil functions in their tissue environment has remained challenging, and for ...
neutrophils, etc ; autoantibodies; complement; macrophages; monocytes; phagocytosis; Show all 6 Subjects
Abstract:
... Autoimmune cytopenias are a consequence of autoantibodies that target blood cell lineages and mark them for their accelerated destruction, mostly through phagocytosis by monocytes and macrophages and complement activation. Neutrophils, although equipped with Fc and complement receptors and effector mechanisms that are critical in other autoimmune conditions, remained long overlooked. Recent report ...
neutrophils, etc ; biocompatible materials; humans; liver; mitochondria; therapeutics; Show all 6 Subjects
Abstract:
... As nanotherapeutics, mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are considered a potent alternative for whole-cell therapy and are gradually entering the clinical field of liver diseases. In this study, neutrophil extracellular traps (NETs) formation in liver tissue was verified as a critical factor for liver ischaemia–reperfusion injury (IRI) in both clinical samples and an ...
neutrophils, etc ; aerobiosis; atherosclerosis; hypertension; immune response; macrophages; Show all 6 Subjects
Abstract:
... Angiotensin converting enzyme (ACE) is well known for its role producing the vasoconstrictor angiotensin II and ACE inhibitors are commonly used for treating hypertension and cardiovascular disease. However, ACE has many different substrates besides angiotensin I and plays a role in many different physiologic processes. Here, we discuss the role of ACE in the immune response. Several studies in mi ...
neutrophils, etc ; gene expression; genes; glucose; meat quality; research; Show all 6 Subjects
Abstract:
... This study investigated the relationship between expression levels of SCD, LPL PPARα, PPARγ and PCK2 genes in the PPAR signaling pathway and blood stress parameters and meat quality in Kivircik lambs. Two trial groups were formed from 4 to 5-month-old lambs, by 0.2 m²/lamb and 0.3 m²/lamb stocking density during transport. The differences between the groups in terms of neutrophil: leukocyte and gl ...
neutrophils, etc ; Artocarpus; chemistry; models; rats; respiratory burst; spectroscopy; Show all 7 Subjects
Abstract:
... Two new prenylated 2-arylbenzofurans, namely artonancins A and B (1 and 2), together with four known ones (3–6), were isolated from the roots of Artocarpus nanchuanensis S. S. Chang for the first time. Their structures were determined by spectroscopic methods. Compounds 1–6 were evaluated for the antirespiratory burst properties using a cellular model reproduced by chemical stimulation of rat neut ...
neutrophils, etc ; Oncorhynchus gorbuscha; Oncorhynchus keta; eosinophils; ichthyology; monocytes; Show all 6 Subjects
Abstract:
... In pink salmon Onchorhynchus gorbuscha and chum salmon O. keta lymphocytes predominate among leukocytes in the peripheral blood during the marine period of life. In both species eosinophils are absent, while in pink salmon basophils are also absent. The proportion of segmented neutrophils and the size of lymphocytes, monocytes, and stab neutrophils are lower in chum salmon than in pink salmon. ...
neutrophils, etc ; Streptococcus pneumoniae; inflammation; macrophages; mice; nasal mucosa; Show all 6 Subjects
Abstract:
... Transmission plays an important role in establishing pneumococcal colonization. It comprises three key events: shedding to transmit, entering into a susceptible new host, and adhering to the mucosal surface. Shedding of pneumococci from the respiratory tract of a colonized host is a pivotal step in transmission. Using a co-housed littermate mouse model, we evaluated the importance of the susceptib ...
neutrophils, etc ; cats; dogs; hospitals; inflammation; monocytes; small animal practice; Show all 7 Subjects
Abstract:
... OBJECTIVES: A common and severe error in identifying neutrophils in feline blood samples by the IDEXX ProCyte Dx haematology analyser (ProCyte) has been reported. The hypothesis was that the same or similar error would be identified during analysis of canine blood samples and that white blood cell dot plot evaluation would be critical to detect and avoid erroneous results. MATERIALS AND METHODS: E ...
neutrophils, etc ; apoptosis; death; intestinal microorganisms; models; mortality; myocardial infarction; Show all 7 Subjects
Abstract:
... Myocardial infarction (MI) is a leading cause of death worldwide for which there is no cure. Percutaneous coronary intervention (PCI) can restore blood supply in a timely manner, which greatly reduces the mortality of patients, but ischemia/reperfusion (I/R) injury is inevitable. A number of clinical studies have shown that gut microbiota play an essential role in cardiovascular diseases. This stu ...
neutrophils, etc ; acidification; animals; cell death; geometry; hypersensitivity; inflammation; luminescence; pH; Show all 9 Subjects
Abstract:
... Understanding the mechanism and progression of neutrophil-involved diseases (e.g., acute inflammation) is of great importance. However, current available analytical methods neither achieve the real-time monitoring nor provide dynamic information during the pathological processes. Herein, a peroxynitrite (ONOO–) and environmental pH dual-responsive afterglow luminescent nanoprobe is designed and sy ...
neutrophils, etc ; Streptococcus; bacterial culture; brain; death; dyes; meningitis; mortality; necropsy; Show all 9 Subjects
Abstract:
... Meningitis, caused by bacterial infections such as Streptococcus spp., is a frequently observed cause of death in pigs. In order to implement effective treatment and avoid further losses, it is important to establish this diagnosis quickly. However, this is often difficult because macroscopic lesions may not be visible, and additional laboratory testing may take several days. The present study inv ...
neutrophils, etc ; antibiotics; dogs; inflammation; plate count; sediments; urinary tract; urine; Show all 8 Subjects
Abstract:
... The diagnosis of urinary tract infections (UTIs) requires a concomitant evaluation of clinical signs and urine culture, which is of fundamental to start an appropriate antibiotic treatment. Several factors, such as subclinical bacteriuria or pre-analytical errors, may make the interpretation of urine culture difficult. The aim of the study was to evaluate the association between the finding of neu ...
neutrophils, etc ; antagonists; cholesterol; cryo-electron microscopy; crystal structure; interleukin-8; Show all 6 Subjects
Abstract:
... The C‐X‐C motif chemokine CXCL8 (interleukin‐8, IL‐8) and its receptor chemokine receptor 2 (CXCR2) mediate neutrophil migration during cell development and inflammatory responses and thus are related to numerous inflammatory diseases and cancers. We have determined the cryo‐electron microscopy structure of CXCL8 bound CXCR2 coupled to Gᵢ protein, as well as the crystal structure of inactive CXCR2 ...
neutrophils, etc ; adsorption; biosensors; breast neoplasms; early diagnosis; ligands; precision medicine; viability; Show all 8 Subjects
Abstract:
... The isolation and analysis of scarce circulating tumor cells (CTCs) with immunomagnetic nanoparticles (IMNs) have shown promising outcomes in noninvasive cancer diagnosis. However, the IMNs adsorb nonspecific proteins after entering into biofluids and the formed protein coronas cover surface targeting ligands, limiting the detection efficiency of IMNs. In addition, the interaction between surface ...
neutrophils, etc ; biomarkers; clinical examination; diarrhea; disease severity; hospitals; inflammation; retrospective studies; Show all 8 Subjects
Abstract:
... OBJECTIVES: To document the neutrophil to lymphocyte ratio (NLR) values in systemic inflammatory response syndrome positive (SIRS+) and negative (SIRS–) puppies presenting with acute diarrhea (AD). To determine whether the calculated canine acute diarrhea severity index (CADSI) score was associated with NLR. Also, to investigate the prognostic value of NLR in puppies with acute diarrhea. DESIGN: R ...
neutrophils, etc ; blood flow; hypoxia; immune response; lungs; metastasis; mortality; neoplasms; prognosis; Show all 9 Subjects
Abstract:
... Tumor metastasis is directly correlated to poor prognosis and high mortality. Circulating tumor cells (CTCs) play a pivotal role in metastatic cascades, of which CTC clusters is highly metastatic compared to single CTCs. Although platelets and neutrophils within the bloodstream could further exacerbate the pro-metastatic effect of single CTCs, the influence of platelets and neutrophils on CTC clus ...