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1. Iron influences on the Gut-Brain axis and development of type 2 diabetes

Author:
Fernández Real, José Manuel; Moreno-Navarrete, José Maria; Manco, Melania
Source:
Critical reviews in food science and nutrition 2019 v.59 no.3 pp. 443-449
ISSN:
1549-7852
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; brain; cognition; intestinal microorganisms; iron; microstructure;     Show all 6 Subjects
Abstract:
... Background: Microbiota/neuroendocrine interactions with health and disease are increasingly recognized. Main Body: Aging is associated with progressive iron storage and development of type 2 diabetes, which impacts on brain microstructure and function, mainly in obese subjects. Iron status is also mutually influencing the composition of the gut microbiota, which in turn may affect cognition throug ...
DOI:
10.1080/10408398.2017.1376616

2. A novel robust approach for analysis of longitudinal data

Author:
Zhang, Yuexia; Qin, Guoyou; Zhu, Zhongyi; Xu, Wanghong
Source:
Computational statistics & data analysis 2019 v.138 pp. 83-95
ISSN:
0167-9473
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; dietary fiber; equations; glycohemoglobin; longitudinal studies; patients;     Show all 6 Subjects
Abstract:
... A new robust estimating equation approach for analysis of longitudinal data is developed. To achieve robustness against outliers, a novel approach which corrects the bias induced by outliers through centralizing the covariate matrix in the estimating equation is proposed. The covariates are centralized by subtracting their conditional expectations and the conditional expectations can be estimated ...
DOI:
10.1016/j.csda.2019.04.002

3. Carnosinase concentration, activity, and CNDP1 genotype in patients with type 2 diabetes with and without nephropathy

Author:
Zhang, Shiqi; Albrecht, Thomas; Rodriguez-Niño, Angelica; Qiu, Jiedong; Schnuelle, Peter; Peters, Verena; Schmitt, Claus Peter; van den Born, Jacob; Bakker, Stephan J. L.; Lammert, Alexander; Krämer, Bernhard K.; Yard, Benito A.; Hauske, Sibylle J.
Source:
Amino acids 2019 v.51 no.4 pp. 611-617
ISSN:
0939-4451
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; blood serum; diabetic nephropathy; enzymes; homozygosity; patients; regression analysis; renal function;     Show all 8 Subjects
Abstract:
... This study assessed if serum carnosinase (CNDP1) activity and concentration in patients with type 2 diabetes mellitus (T2D) with diabetic nephropathy (DN) differs from those without nephropathy. In a cross-sectional design 127 patients with T2D with DN ((CTG)₅ homozygous patients n = 45) and 145 patients with T2D without nephropathy ((CTG)₅ homozygous patients n = 47) were recruited. Univariate an ...
DOI:
10.1007/s00726-018-02692-0

4. Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues

Author:
Ruiz de Azua, Inigo; Lutz, Beat
Source:
Cellular and molecular life sciences 2019 v.76 no.7 pp. 1341-1363
ISSN:
1420-682X
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; brain; cannabinoids; energy intake; homeostasis; hunger; metabolism; mice; obesity; tissues;     Show all 10 Subjects
Abstract:
... The endocannabinoid (eCB) system is widely expressed in many central and peripheral tissues, and is involved in a plethora of physiological processes. Among these, activity of the eCB system promotes energy intake and storage, which, however, under pathophysiological conditions, can favour the development of obesity and obesity-related disorders. It is proposed that eCB signalling is evolutionary ...
DOI:
10.1007/s00018-018-2994-6

5. Treatment of obesity in older persons—A systematic review

Author:
Haywood, Cilla; Sumithran, Priya
Source:
Obesity reviews 2019 v.20 no.4 pp. 588-598
ISSN:
1467-7881
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; bariatric surgery; databases; elderly; lifestyle; obesity; systematic review; weight loss;     Show all 8 Subjects
Abstract:
... The study aims to systematically review the available evidence regarding weight loss interventions (lifestyle, surgical, and pharmacological) for obesity in adults aged over 60 years. A search of prospective, randomized studies took place in January 2018, on Medline (Web of Science) and PubMed databases. Search terms included the following: elderly, obese, hypocaloric, pharmacotherapy, and bariatr ...
DOI:
10.1111/obr.12815

6. MetaPheno: A critical evaluation of deep learning and machine learning in metagenome-based disease prediction

Author:
LaPierre, Nathan; Ju, Chelsea J.-T.; Zhou, Guangyu; Wang, Wei
Source:
Methods 2019
ISSN:
1046-2023
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; algorithms; artificial intelligence; data collection; experimental design; humans; metagenomics; microbiome; obesity; prediction;     Show all 10 Subjects
Abstract:
... The human microbiome plays a number of critical roles, impacting almost every aspect of human health and well-being. Conditions in the microbiome have been linked to a number of significant diseases. Additionally, revolutions in sequencing technology have led to a rapid increase in publicly-available sequencing data. Consequently, there have been growing efforts to predict disease status from meta ...
DOI:
10.1016/j.ymeth.2019.03.003

7. Overview of genomics and post-genomics research on type 2 diabetes mellitus: Future perspectives and a framework for further studies

Author:
Reddy, Battini Mohan; Pranavchand, Rayabarapu; Latheef, S A A
Source:
Journal of biosciences 2019 v.44 no.1 pp. 21
ISSN:
0250-5991
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; computational methodology; environmental factors; genetic disorders; genomics; lifestyle; pathophysiology; research planning; urbanization;     Show all 9 Subjects
Abstract:
... In this review, we briefly outlined salient features of pathophysiology and results of the genetic association studies hitherto conducted on type 2 diabetes. Primarily focusing on the current status of genomic research, we briefly discussed the limited progress made during the post-genomic era and tried to identify the limitations of the post-genomic research strategies. We suggested reanalysis of ...
DOI:
10.1007/s12038-018-9818-6

8. IL- 17 production by NKG2D-expressing CD56+ T cells in type 2 diabetes

Author:
Phoksawat, Wisitsak; Jumnainsong, Amonrat; Leelayuwat, Naruemon; Leelayuwat, Chanvit
Source:
Molecular immunology 2019 v.106 pp. 22-28
ISSN:
0161-5890
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; T-lymphocytes; glycemic control; interleukin-17; pathogenesis; patients;     Show all 6 Subjects
Abstract:
... T cells expressing CD56 (identified as CD3+CD56+) play a potential role in activation or regulation of other immune cells by secreting various cytokines. We hypothesized that these cells expressing the natural group 2, member D (NKG2D) could produce high levels of interleukin (IL)-17 in type 2 diabetes (T2D). CD56 + T cells expressing NKG2D of T2D patients, particularly in poor glycemic control (P ...
DOI:
10.1016/j.molimm.2018.12.008

9. SAD-A, a downstream mediator of GLP-1 signaling, promotes the phosphorylation of Bad S155 to regulate in vitro β-cell functions

Author:
Wang, Kai; Liu, Dechen; Zhang, Yaqin; Chang, Xiaoai; Xu, Rufeng; Pang, Jing; Li, Kai; Sun, Peng; Zhu, Yunxia; Han, Xiao
Source:
Biochemical and biophysical research communications 2019 v.509 no.1 pp. 76-81
ISSN:
0006-291X
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; apoptosis; glucagon-like peptide 1; islets of Langerhans; patients; phosphorylation; secretin; secretion;     Show all 8 Subjects
Abstract:
... The incretin hormone GLP-1 reduces β-cell failure in patients with type 2 diabetes. Previous studies demonstrated that GLP-1 activates SAD-A, a member of the AMPK family, to regulate glucose-stimulated secretion (GSIS), but the underlying mechanisms of SAD-A regulation of β-cell functions remain poorly understood. Here, we propose that activation of SAD-A by GLP-1 promotes the phosphorylation of B ...
DOI:
10.1016/j.bbrc.2018.12.063

10. Prescribing high-intensity interval exercise by RPE in individuals with type 2 diabetes: metabolic and hemodynamic responses

Author:
Viana, Ariane Aparecida; Fernandes, Bianca; Alvarez, Cristian; Guimarães, Guilherme Veiga; Ciolac, Emmanuel Gomes
Source:
Applied physiology, nutrition and metabolism 2019 v.44 no.4 pp. 348-356
ISSN:
1715-5320
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; blood glucose; blood pressure; exercise; exercise test; glucose; heart rate;     Show all 7 Subjects
Abstract:
... We tested the hypothesis that rating of perceived exertion (RPE) is a tool as efficient as the heart rate (HR) response to the cardiopulmonary exercise test (CPX) for prescribing and self-regulating high-intensity interval exercise (HIIE), and that metabolic and hemodynamic response to HIIE is superior than to continuous moderate-intensity exercise (MICE) in individuals with type 2 diabetes mellit ...
DOI:
10.1139/apnm-2018-0371

11. Semiparametric Kernel-Based Regression for Evaluating Interaction Between Pathway Effect and Covariate

Author:
Fang, Zaili; Kim, Inyoung; Jung, Jeesun
Source:
Journal of agricultural, biological, and environmental statistics 2018 v.23 no.1 pp. 129-152
ISSN:
1085-7117
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; genes; models;     Show all 3 Subjects
Abstract:
... Pathway-based analysis has the ability to detect subtle changes in response variables that could be missed when using gene-based analysis. Since genes interact with other covariates such as environmental or clinical variables, so do pathways, which are sets of genes that serve particular cellular or physiological functions. However, since pathways are sets of genes and since environmental or clini ...
DOI:
10.1007/s13253-017-0317-2

12. Different training durations and styles of tai chi for glucose control in patients with type 2 diabetes: a systematic review and meta-analysis of controlled trials

Author:
Xia, Ting-Wei; Yang, Yue; Li, Wei-Hong; Tang, Zhao-Hui; Li, Zong-Run; Qiao, Li-Jun
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 63
ISSN:
1472-6882
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; alternative medicine; blood glucose; databases; disease control; glycemic control; meta-analysis; patients; physical activity; systematic review;     Show all 10 Subjects
Abstract:
... BACKGROUND: Physical activity is an important part of the diabetes management plan. However, the effects caused by different training durations and styles of Tai Chi have not been evaluated. We conducted an updated systematic review of the effects of Tai Chi on patients with type 2 diabetes based on different training durations and styles. METHODS: We performed a search for Chinese and English stu ...
DOI:
10.1186/s12906-019-2475-y

13. Combined magnetic ligand fishing and high-resolution inhibition profiling for identification of α-glucosidase inhibitory ligands: A new screening approach based on complementary inhibition and affinity profiles

Author:
Wubshet, Sileshi G.; Liu, Bingrui; Kongstad, Kenneth T.; Böcker, Ulrike; Petersen, Malene J.; Li, Tuo; Wang, Junru; Staerk, Dan
Source:
Talanta 2019 v.200 pp. 279-287
ISSN:
0039-9140
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; Ginkgo biloba; alpha-glucosidase; enzyme inhibition; enzyme inhibitors; ethyl acetate; ligands; magnetism; plant extracts; screening;     Show all 10 Subjects
Abstract:
... Plants are well-recognized sources of inhibitors for α-glucosidase – a key target enzyme for management of type 2 diabetes. Recently, two advanced bioactivity-profiling techniques, i.e., ligand fishing and high-resolution inhibition profiling, have shown great promises for accelerating identification of α-glucosidase inhibitors from complex plant extracts. Non-specific affinities and non-specific ...
DOI:
10.1016/j.talanta.2019.03.047

14. Funding sources and outcomes of dairy consumption research – A meta-analysis of cohort studies: The case of type-2 diabetes and cardiovascular diseases

Author:
Mishali, Moshe; Kisner, Mirit; Avrech, Tova
Source:
International dairy journal 2019 v.95 pp. 65-70
ISSN:
0958-6946
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; cardiovascular diseases; cohort studies; dairy consumption; food industry; funding; meta-analysis; risk reduction;     Show all 8 Subjects
Abstract:
... Despite requirements to disclose funding sources and contributors involved with published research, industry-funded research is frequently viewed as inherently biased. A meta-analysis (29 cohort studies) was conducted to investigate the association between dairy consumption and the risk of type-2 diabetes (T2D) and cardiovascular diseases (CVD), comparing findings from industry-funded versus non-i ...
DOI:
10.1016/j.idairyj.2019.02.019

15. Dietary Beliefs and Management of Older American Indians With Type 2 Diabetes

Author:
Schure, Mark; Goins, Ruth Turner; Jones, Jacqueline; Winchester, Blythe; Bradley, Vickie
Source:
Journal of nutrition education and behavior 2019 v.51 no.7 pp. 826-833
ISSN:
1499-4046
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; American Indians; elderly; health care workers; healthy diet; interviews; nutrition education; portion size; social support;     Show all 9 Subjects
Abstract:
... This qualitative study examined dietary-related beliefs and self-management among older American Indians with type 2 diabetes mellitus (T2DM).Semistructured in-person interviews were conducted and digitally recorded.Southeastern American Indian tribal community.A total of 28 noninstitutionalized older tribal members aged >60 years.Study participants’ beliefs and experiences with dietary practices ...
DOI:
10.1016/j.jneb.2018.11.007

16. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

Author:
Garcia-Arellano, Ana; Martínez-González, Miguel A.; Ramallal, Raul; Salas-Salvadó, Jordi; Hébert, James R.; Corella, Dolores; Shivappa, Nitin; Forga, Luis; Schröder, Helmut; Muñoz-Bravo, Carlos; Estruch, Ramón; Fiol, Miquel; Lapetra, José; Serra-Majem, Lluís; Ros, Emilio; Rekondo, Javier; Toledo, Estefanía; Razquin, Cristina; Ruiz-Canela, Miguel; Alonso, A.; Barrio Lopez, M.T.; Basterra-Gortari, F.J.; Benito Corchon, S.; Bes-Rastrollo, M.; Beunza, J.J.; Carlos, S.; Cervantes, S.; de Irala, J.; de la Rosa, P.A.; de la Fuente, C.; Donat-Vargas, C.L.; Donazar, M.; Fernandez Montero, A.; Gea, A.; Goni-Ochandorena, E.; Guillen-Grima, F.; Lahortiga, F.; Llorca, J.; Lopez del Burgo, C.; Mari-Sanchıs, A.; Marti, A.; Mendonça, R.; Nuñez-Cordoba, J.M.; Pimenta, A.M.; Rico, A.; Ruiz Zambrana, A.; Sayon-Orea, C.; Toledo-Atucha, J.; Vazquez Ruiz, Z.; Zazpe Garcıa, I.; Sánchez- Tainta, A.; Buil-Cosiales, P.; Díez-Espino, J.; Sanjulian, B.; Martínez, J.A.; Marti, A.; Serrano-Martínez, M.; Basterra-Gortari, F.J.; Extremera-Urabayen, J.V.; Garcia-Pérez, L.; Arroyo-Azpa, C.; Barcena, A.F.; Oreja-Arrayago, C.; Lasanta-Sáez, M.J.; Cia-Lecumberri, P.; Elcarte-Lopez, T.; Artal-Moneva, F.; Esparza-López, J.M.; Figuerido-Garmendia, E.; Tabar-Sarrias, J.A.; Fernández- Urzainqui, L.; Ariz-Arnedo, M.J.; Cabeza-Beunza, J.A.; Pascual-Pascual, P.; Martínez-Mazo, M.D.; Arina-Vergara, E.; Macua-Martínez, T.; Pascual Pascual, P.; Garcés Ducar, M.L.; Martí Massó, R.; Villanueva Moreno, R.; Parra-Osés, A.; Serra-Mir, M.; Pérez-Heras, A.; Viñas, C.; Casas, R.; Medina-Remon, A.; Villanueva, P.; Baena, J.M.; García, M.; Oller, M.; Amat, J.; Duaso, I.; García, Y.; Iglesias, C.; Simón, C.; Quinzavos, L.; Parra, L.; Liroz, M.; Benavent, J.; Clos, J.; Pla, I.; Amorós, M.; Bonet, M.T.; Martín, M.T.; Sánchez, M.S.; Altirriba, J.; Manzano, E.; Altés, A.; Cofán, M.; Valls-Pedret, C.; Sala-Vila, A.; Doménech, M.; Bulló, M.; Basora-Gallisa, J.; González, R.; Molina, C.; Mena, G.; Martínez, P.; Ibarrola, N.; Sorlí, J.; García Roselló, J.; Martin, F.; Tort, N.; Isach, A.; Babio, N.; Salas-Huetos, A.; Becerra-Tomás, N.; Rosique- Esteban, N.; Hernandez, P.; Canudas, S.; Papandreou, C.; Ferreira, C.; Cabre, M.; Mestres, G.; Paris, F.; Llauradó, M.; Pedret, R.; Basells, J.; Vizcaino, J.; Segarra, R.; Giardina, S.; Guasch-Ferré, M.; Díaz-López, A.; Fernández-Ballart, J.; Balanza, R.; Tello, S.; Vila, J.; de la Torre, R.; Muñoz-Aguayo, D.; Elosua, R.; Marrugat, J.; Schröder, H.; Molina, N.; Maestre, E.; Rovira, A.; Castañer, O.; Farré, M.; Sorli, J.; Carrasco, P.; Ortega-Azorín, C.; Asensio, E.M.; Osma, R.; Barragán, R.; Francés, F.; Guillén, M.; González, J.I.; Sáiz, C.; Portolés, O.; Giménez, F.J.; Coltell, O.; Fernández-Carrión, R.; Guillem-Sáiz, P.; González-Monje, I.; Quiles, L.; Pascual, V.; Riera, C.; Pages, M.A.; Godoy, D.; Carratalá-Calvo, A.; Sánchez-Navarro, S.; Valero-Barceló, C.; Salaverria, I.; Hierro, T. del; Algorta, J.; Francisco, S.; Alonso, A.; San Vicente, J.; Casi, A.; Sanz, E.; Felipe, I.; Rekondo, J.; Loma-Osorio, A.; Fernandez-Crehuet, J.; Garcia-Rodriguez, A.; Wärnberg, J.; Benitez Pont, R.; Bianchi Alba, M.; Navajas, R.; Gómez-Huelgas, R.; Martínez-González, J.; Velasco García, V.; de Diego Salas, J.; Baca Osorio, A.; Gil Zarzosa, J.; Sánchez Luque, J.J.; Vargas López, E.; Romaguera, D.; García-Valdueza, M.; Proenza, A.; Prieto, R.; Frontera, G.; Munuera, S.; Vivó, M.; Bestard, F.; Munar, J.A.; Coll, L.; Fiol, F.; Ginard, M.; Jover, A.; García, J.; Santos-Lozano, J.M.; Ortega-Calvo, M.; Leal, M.; Martínez, E.; Mellado, L.; Miró-Moriano, L.; Domínguez-Espinaco, C.; Vaquero- Diaz, S.; Iglesias, P.; Román, P.; Corchado, Y.; Lozano-Rodríguez, J.M.; Lamuela-Raventós, R.; López- Sabater, M.C.; Castellote-Bargalló, A.I.; Quifer-Rada, P.; Tresserra-Rimbau, A.; Alvarez-Pérez, J.; Díez Benítez, E.; Bautista Castaño, I.; Maldonado Díaz, I.; Sanchez-Villegas, A.; Férnandez- Rodríguez, M.J.; Sarmiendo de la Fe, F.; Simón García, C.; Falcón Sanabria, I.; Macías Gutiérrez, B.; Santana Santana, A.J.; de la Cruz, E.; Galera, A.; Pintó-Salas, X.; Trias, F.; Sarasa, I.; Rodríguez, M.A.; Corbella, X.; Corbella, E.; Goday, A.; Muñoz, M.A.; Cabezas, C.; Vinyoles, E.; Rovira, M.A.; Garcia, L.; Baby, P.; Ramos, A.; Mengual, L.; Roura, P.; Yuste, M.C.; Guarner, A.; Rovira, A.; Santamaria, M.I.; Mata, M.; de Juan, C.; Brau, A.; Fernandez, M.; Gutierrez, E.; Murillo, C.; Garcia, J.; Tafalla, M.; Bobe, I.; Díaz, A.; Araque, M.; Solis, E.; Cervello, T.; Montull, I.; Tur, J.A.; Portillo, M.P.; Sáez, G.
Source:
Clinical nutrition 2019 v.38 no.3 pp. 1221-1231
ISSN:
0261-5614
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; cardiovascular diseases; chronic diseases; death; diet; eating habits; inflammation; meta-analysis; mortality; neoplasms; obesity; prospective studies;     Show all 12 Subjects
Abstract:
... Inflammation is known to be related to the leading causes of death including cardiovascular disease, several types of cancer, obesity, type 2 diabetes, depression-suicide and other chronic diseases. In the context of whole dietary patterns, the Dietary Inflammatory Index (DII®) was developed to appraise the inflammatory potential of the diet.We prospectively assessed the association between DII sc ...
DOI:
10.1016/j.clnu.2018.05.003

17. Recent advances in the development of sesquiterpenoids in the treatment of type 2 diabetes

Author:
Chen, Lei; Lu, Xu; El-Seedi, Hesham; Teng, Hui
Source:
Trends in food science & technology 2019 v.88 pp. 46-56
ISSN:
0924-2244
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; clearcutting; enzymes; food industry; glucose; herbs; hyperglycemia; insulin; islets of Langerhans; lipids; pathogenesis; pharmaceutical industry; sesquiterpenoids;     Show all 13 Subjects
Abstract:
... Treatment of type 2 diabetes mellitus (T2DM) through dietary terpenoids is receiving a promising interest and sesquiterpenoids’ importance for food and pharmaceutical industries is mainly based on the existed scientific works.Sesquiterpenoids might contribute to prevent or delay T2DM by inhibiting key enzymes relevant for hyperglycemia, modulating β-cells function, targeting insulin signaling rout ...
DOI:
10.1016/j.tifs.2019.02.003

18. The continuums of impairment in vascular reactivity across the spectrum of cardiometabolic health: A systematic review and network meta‐analysis

Author:
Loader, Jordan; Khouri, Charles; Taylor, Frances; Stewart, Simon; Lorenzen, Christian; Cracowski, Jean‐Luc; Walther, Guillaume; Roustit, Matthieu
Source:
Obesity reviews 2019 v.20 no.6 pp. 906-920
ISSN:
1467-7881
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; blood glucose; databases; glucose tolerance; insulin resistance; meta-analysis; metabolic syndrome; obesity; pathogenesis; patients; systematic review;     Show all 11 Subjects
Abstract:
... This study aimed to assess, for the first time, the change in vascular reactivity across the full spectrum of cardiometabolic health. Systematic searches were conducted in MEDLINE and EMBASE databases from their inception to March 13, 2017, including studies that assessed basal vascular reactivity in two or more of the following health groups (aged ≥18 years old): healthy, overweight, obesity, imp ...
DOI:
10.1111/obr.12831

19. Melatonin Concentrations and Sleep Quality in Patients with Type 2 Diabetes and Obesity

Author:
Kalere, Ieva; Konrāde, Ilze; Proskurina, Anna; Upmale, Sabīne; Zaķe, Tatjana; Limba, Normunds; Krieviņa, Gita; Lejnieks, Aivars; Tretjakovs, Pēteris
Source:
Proceedings of the Latvian Academy of Sciences 2019 v.73 no.2 pp. 152-157
ISSN:
1407-009X
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; body mass index; diabetic retinopathy; glucagon; insulin; melatonin; obesity; patients; questionnaires; saliva; sleep; somatostatin;     Show all 12 Subjects
Abstract:
... There is a close relationship between melatonin as a circadian regulator and insulin, glucagon and somatostatin production. This study aimed to describe subgroups of type 2 diabetes mellitus (T2DM) patients that may benefit from melatonin clock-targeting properties. The study involved 38 participants: 26 T2DM patients, and 12 participants without diabetes in the control group. Subjects were asked ...
DOI:
10.2478/prolas-2019-0024

20. Italian Titration Approach Study (ITAS) with insulin glargine 300 U/mL in insulin-naïve type 2 diabetes: Design and population

Author:
Bonadonna, R.C.; Giaccari, A.; Buzzetti, R.; Aimaretti, G.; Cucinotta, D.; Avogaro, A.; Perseghin, G.; Larosa, M.; Bolli, G.B.; Fanelli, C.G.
Source:
Nutrition, metabolism, and cardiovascular diseases 2019 v.29 no.5 pp. 496-503
ISSN:
0939-4753
Subject:
noninsulin-dependent diabetes mellitus,   etc   ; algorithms; body mass index; glucose; glycemic control; glycohemoglobin; insulin; insulin replacement therapy; managers; monitoring; patients; titration;     Show all 12 Subjects
Abstract:
... Fostering patient's self-managing of basal insulin therapy could improve glucose control, by removing patient's and physician's barriers to basal insulin initiation, titration and glucose monitoring. The Italian Titration Approaches Study (ITAS) aims at demonstrating non-inferiority (<0.3% margin) in efficacy of glucose control (change in glycated hemoglobin [HbA1c] after 24 weeks) by the same tit ...
DOI:
10.1016/j.numecd.2019.01.011