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1. Omega-3 Supplementation for the Prevention of Cognitive Decline in Older Adults: Does It Depend on Homocysteine Levels?

Author:
Mathieu Maltais; P. de Souto Barreto; G. L. Bowman; A. D. Smith; C. Cantet; S. Andrieu; Y. Rolland; MAPT/DSA Study Group
Source:
The Journal of nutrition, health and aging 2022 v.26 no.6 pp. 615-620
ISSN:
1760-4788
Subject:
omega-3 fatty acids,   etc   ; cognition; cognitive disorders; dementia; erythrocytes; homocysteine; nutrition;     Show all 7 Subjects
Abstract:
... BACKGROUND: Recent evidence point towards an interaction between omega-3 (n-3) polyunsaturated fatty acids (PUFA) and plasma homocysteine (Hcy). OBJECTIVES: This study tested the hypothesis that effects of red blood cell n-3 PUFA are modified according to baseline plasma Hcy in the large Mulit-domain Alzheimer Prevention Trial (MAPT) throughout the 3-years of treatment with an additional 2 years o ...
DOI:
10.1007/s12603-022-1809-5

2. Omega-3 Fatty Acids for the Management of Osteoarthritis: A Narrative Review

Author:
Dean M. Cordingley; Stephen M. Cornish
Source:
Nutrients 2022 v.14 no.16 pp. -
ISSN:
2072-6643
Subject:
omega-3 fatty acids,   etc   ; cartilage; catabolism; homeostasis; inflammation; osteoarthritis; therapeutics; Canada;     Show all 8 Subjects
Abstract:
... Osteoarthritis (OA) is a disease which results in degeneration of cartilage within joints and affects approximately 13.6% of adults over 20 years of age in Canada and the United States of America. OA is characterized by a state of low-grade inflammation which leads to a greater state of cellular catabolism disrupting the homeostasis of cartilage synthesis and degradation. Omega-3 polyunsaturated f ...
DOI:
10.3390/nu14163362

3. Optimization of Omega-3 Index Levels in Athletes at the US Naval Academy: Personalized Omega-3 Fatty Acid Dosage and Molecular Genetic Approaches

Author:
Melissa Rittenhouse; Nyamkhishig Sambuughin; Patricia Deuster
Source:
Nutrients 2022 v.14 no.14 pp. -
ISSN:
2072-6643
Subject:
omega-3 fatty acids,   etc   ; cardiovascular diseases; clinical trials; fatty acid desaturase; risk;     Show all 5 Subjects
Abstract:
... The Dietary Guidelines for Americans recommend increasing the intake of omega-3 polyunsaturated fatty acids. The Omega-3 Index (O3I) is one marker used to assess omega-3 status. The O3I national average is 4.3%, which translates into a high risk for developing cardiovascular disease. Research has reported an association between variants in the two desaturase encoding genes, fatty acid desaturase 1 ...
DOI:
10.3390/nu14142966

4. Omega-3 Polyunsaturated Fatty Acids Can Reduce C-Reactive Protein in Patients with Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Author:
Lei Pan; Yun Zhou; Haitao Yin; Hui Hui; Yongzhong Guo; Xiaomei Xie
Source:
Nutrition and cancer 2022 v.74 no.3 pp. 840-851
ISSN:
1532-7914
Subject:
omega-3 fatty acids,   etc   ; C-reactive protein; inflammation; meta-analysis; nutrition; systematic review;     Show all 6 Subjects
Abstract:
... Omega-3 polyunsaturated fatty acids (PUFAs) possess anti-inflammatory properties. There is a lack of consensus regarding the effects of omega-3 PUFAs on C-reactive protein (CRP), a marker of systemic inflammation, in cancer patients. Herein, a meta-analysis of randomized controlled trials was conducted to evaluate the effects of omega-3 PUFAs on CRP levels in patients with cancer. PubMed and EMBAS ...
DOI:
10.1080/01635581.2021.1931365

5. Liposomal encapsulation of omega‐3 fatty acid and α‐lipoic acid conjugate for cow milk fortification

Author:
Pintu Choudhary; Sayantani Dutta; J. A. Moses; C. Anandharamakrishnan
Source:
Journal of food processing and preservation 2022 v.46 no.9 pp. e16082
ISSN:
0145-8892
Subject:
omega-3 fatty acids,   etc   ; Salvia hispanica; bioactive compounds; encapsulation; milk; oils; oxidation; particle size;     Show all 8 Subjects
Abstract:
... α‐linolenic acid (ALA) and α‐lipoic acid (LA) are well‐known bioactives with salutary effects and are potential health supplements. However, they are susceptible to oxidation. To enhance the stability of these fatty acids in dietary products/supplements, the present study was conducted to encapsulate chia oil (as the source of ALA), and LA, together in liposomes. The LA inclusion complex with hydr ...
DOI:
10.1111/jfpp.16082

6. n-3 long-chain PUFA promote antibacterial and inflammation-resolving effects in Mycobacterium tuberculosis-infected C3HeB/FeJ mice, dependent on fatty acid status

Author:
Arista Nienaber; Mumin Ozturk; Robin Dolman; Renee Blaauw; Lizelle L. Zandberg; Simone van Rensburg; Melinda Britz; Frank E. A. Hayford; Frank Brombacher; Du Toit Loots; Cornelius M. Smuts; Suraj P. Parihar; Linda Malan
Source:
British journal of nutrition 2022 v.127 no.3 pp. 384-397
ISSN:
1475-2662
Subject:
omega-3 fatty acids,   etc   ; cell structures; diet; inflammation; interleukin-17; lungs; microbial load; tuberculosis;     Show all 8 Subjects
Abstract:
... Non-resolving inflammation is characteristic of tuberculosis (TB). Given their inflammation-resolving properties, n-3 long-chain PUFA (n-3 LCPUFA) may support TB treatment. This research aimed to investigate the effects of n-3 LCPUFA on clinical and inflammatory outcomes of Mycobacterium tuberculosis-infected C3HeB/FeJ mice with either normal or low n-3 PUFA status before infection. Using a two-by ...
DOI:
10.1017/S0007114521001124

7. Primary Prevention of Pediatric Asthma through Nutritional Interventions

Author:
Giulia Nuzzi; Maria Di Cicco; Irene Trambusti; Massimo Agosti; Diego G. Peroni; Pasquale Comberiati
Source:
Nutrients 2022 v.14 no.4 pp. -
ISSN:
2072-6643
Subject:
omega-3 fatty acids,   etc   ; asthma; childhood; immune system; infancy; pathogenesis; pregnancy; risk; risk reduction;     Show all 9 Subjects
Abstract:
... Asthma is the most common chronic non-communicable disease in children, the pathogenesis of which involves several factors. The increasing burden of asthma worldwide has emphasized the need to identify the modifiable factors associated with the development of the disease. Recent research has focused on the relationship between dietary factors during the first 1000 days of life (including pregnancy ...
DOI:
10.3390/nu14040754

8. Synergistic Effects of Folic Acid and n-3 Polyunsaturated Fatty Acid in Preventing Neural Tube Defects in Diabetic Mice

Author:
Kelei Li; Xianfeng Shao; Huiying Li; Xiaotong Kuang; Xiaolei Song; Yan Wang; Suqin Zhu; Duo Li
Source:
Journal of agricultural and food chemistry 2022 v.70 no.36 pp. 11281-11289
ISSN:
1520-5118
Subject:
omega-3 fatty acids,   etc   ; apoptosis; diabetes mellitus; folic acid; food chemistry; homocysteine; metabolism; synergism;     Show all 8 Subjects
Abstract:
... The present study aimed to investigate whether a combination of folic acid (FA) and n-3 polyunsaturated fatty acids (PUFA) has a better preventive effect on maternal diabetes-induced neural tube defects (NTD) than FA alone. The experiment included five groups of pregnant mice: healthy control (HC), diabetes mellitus control (DMC), diabetes + n-3 PUFA (DMn-3), diabetes + FA (DMFA), and diabetes + F ...
DOI:
10.1021/acs.jafc.2c03806

9. N-3 PUFAs and their specialized pro-resolving lipid mediators on airway inflammatory response: beneficial effects in the prevention and treatment of respiratory diseases

Author:
Jessica Zúñiga-Hernández; Verónica Sambra; Francisca Echeverría; Luis A. Videla; Rodrigo Valenzuela
Source:
Food & function 2022 v.13 no.8 pp. 4260-4272
ISSN:
2042-650X
Subject:
omega-3 fatty acids,   etc   ; asthma; docosahexaenoic acid; eicosapentaenoic acid; fever; inflammation; lung function; nose;     Show all 8 Subjects
Abstract:
... Respiratory diseases include a wide range of pathologies with different clinical manifestations, affecting the normal airways and lung function. An increase in the inflammatory response is considered a characteristic hallmark of these diseases, being also a critical factor for their progression. The n-3 polyunsaturated fatty acids (n-3 PUFAs) eicosapentaenoic acid (C20:4n-3, EPA), docosahexaenoic ...
DOI:
10.1039/d1fo03551g

10. Tilapia can be a Beneficial n-3 LC-PUFA Source due to Its High Biosynthetic Capacity in the Liver and Intestine

Author:
Dizhi Xie; Junfeng Guan; Xiaoping Huang; Chao Xu; Qing Pan; Yuanyou Li
Source:
Journal of agricultural and food chemistry 2022 v.70 no.8 pp. 2701-2711
ISSN:
1520-5118
Subject:
omega-3 fatty acids,   etc   ; biosynthesis; brain; diet; food chemistry; human health; intestines; linoleic acid; liver;     Show all 9 Subjects
Abstract:
... To assess whether farmed tilapia can be a beneficial n-3 long-chain polyunsaturated fatty acid (LC-PUFA) source for human health, four diets with linoleic acid (LA) to α-linolenic acid (ALA) ratios at 9, 6, 3, and 1 were prepared to feed juveniles for 10 weeks, and the LC-PUFA biosynthetic characteristics in the liver, intestine, and brain and the muscular quality were analyzed. It was shown that ...
DOI:
10.1021/acs.jafc.1c05755

11. The effects of frozen storage on fatty acids, amino acids, and volatile compounds in mutton stored for 90 days

Author:
Xiaona He; Hongbo Wang; Xiaoling Yang; Bin Xi; Weihong Li; Fang Wang; Hongqiang Li; Yaqin Gao
Source:
Journal of food processing and preservation 2022 v.46 no.5 pp. e16518
ISSN:
0145-8892
Subject:
omega-3 fatty acids,   etc   ; flavor; frozen storage; models; mutton; shelf life; spoilage; storage time; variance;     Show all 9 Subjects
Abstract:
... Frozen storage can delay mutton meat spoilage to the maximum extent, prolonging its shelf life. In this experiment, mutton refrigerated for 24 h was used as the control group and that stored at −18°C was used as the experimental group to explore the effects of frozen storage for 90 days on FA, AA, and VOC of the mutton. The results showed that FA, AA, and VOC changed significantly during storage. ...
DOI:
10.1111/jfpp.16518

12. Advances in enzyme biocatalysis for the preparation of functional lipids

Author:
Haiyang Zhang; Francesco Secundo; Jianan Sun; Xiangzhao Mao
Source:
Biotechnology advances 2022 v.61 pp. 108036
ISSN:
0734-9750
Subject:
omega-3 fatty acids,   etc   ; biocatalysis; biotechnology; carboxylic ester hydrolases; docosahexaenoic acid; eicosapentaenoic acid; immobilized enzymes; phospholipases;     Show all 8 Subjects
Abstract:
... Functional lipids, mainly ω-3 polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic (EPA; 20:5n-3) and docosahexaenoic (DHA; 22:6n-3), are known to have a variety of health benefits. Lipases and phospholipases are widely used to prepare different forms of structured lipids, since biocatalytic methods can be carried out under mild conditions, preserving the quality of the products. On th ...
DOI:
10.1016/j.biotechadv.2022.108036

13. Association of Fish and Omega-3 Fatty Acid Intake with Carotid Intima-Media Thickness in Middle-Aged to Elderly Japanese Men and Women: The Toon Health Study

Author:
Koutatsu Maruyama; Salsabila Khairunnisa; Isao Saito; Takeshi Tanigawa; Kiyohide Tomooka; Satomi Minato-Inokawa; Madoka Sano; Misaki Takakado; Ryoichi Kawamura; Yasunori Takata; Haruhiko Osawa
Source:
Nutrients 2022 v.14 no.17 pp. -
ISSN:
2072-6643
Subject:
omega-3 fatty acids,   etc   ; atherosclerosis; elderly; fish; fish consumption; myocardial infarction; odds ratio; regression analysis; ultrasonics;     Show all 9 Subjects
Abstract:
... Fish and omega-3 fatty acid consumption is known to be beneficial for cardiometabolic health. However, the related evidence for individuals with a relatively higher intake of fish or omega-3 unsaturated fatty acids, e.g., Japanese individuals, is scarce. Therefore, this study aimed to examine the association of fish and omega-3 fatty acid intakes with the carotid intima-media thickness (C-IMT) in ...
DOI:
10.3390/nu14173644

14. Body weight, organ development and jejunal histomorphology in broiler breeder pullets fed n-3 fatty acids enriched diets from hatch through to 22 weeks of age

Author:
Aizwarya Thanabalan; Elijah G. Kiarie
Source:
Poultry science 2022 v.101 no.1 pp. 101514
ISSN:
0032-5791
Subject:
omega-3 fatty acids,   etc   ; broiler breeders; diet; docosahexaenoic acid; jejunum; linseed; liver; microalgae; spleen; tissue weight;     Show all 10 Subjects
Abstract:
... Dietary long chain polyunsaturated n-3 fatty acids (n-3 FA) may be beneficial to broiler breeder (BB) development. Therefore, the effects of feeding sources of docosahexaenoic acid (DHA) and α-linolenic acid (ALA) from hatch through to 22 weeks of age (woa) on growth, organ weight, and jejunal histomorphology were investigated. A total of 588-day-old Ross × Ross 708 BB were reared on one of 3 diet ...
DOI:
10.1016/j.psj.2021.101514

15. Dietary olive leaves improve the quality and the consumer preferences of a model sheep cheese

Author:
Viviana Bolletta; Mariano Pauselli; Camilla Pomente; Antonio Natalello; Luciano Morbidini; Gianluca Veneziani; Valerio Granese; Bernardo Valenti
Source:
International dairy journal 2022 v.134 pp. 105464
ISSN:
0958-6946
Subject:
omega-3 fatty acids,   etc   ; antioxidant activity; cholesterol; consumer acceptance; consumer preferences; lipid content; olives; sheep cheese;     Show all 8 Subjects
Abstract:
... During a 30-day experimental period, twenty grazing Comisana ewes received a commercial feed (CTRL) or a concentrate containing 28% dried olive leaves (LEAVES) to investigate the effect on yield and quality of a model cheese and on consumer preference. Cheese yield measured at 0- and 60-days of ageing was greater for LEAVES group. Dietary olive leaves increased cheese fat content, which showed low ...
DOI:
10.1016/j.idairyj.2022.105464

16. Changes in Serum, Red Blood Cell, and Colonic Fatty Acids in a Personalized Omega-3 Fatty Acid Supplementation Trial

Author:
Yifan Shen; Ananda Sen; D. Kim Turgeon; Jianwei Ren; Gillian Graifman; Mack T. Ruffin; William L. Smith; Dean E. Brenner; Zora Djuric
Source:
Nutrition and cancer 2022 v.74 no.2 pp. 565-578
ISSN:
1532-7914
Subject:
omega-3 fatty acids,   etc   ; arachidonic acid; blood serum; clinical trials; colon; eicosapentaenoic acid; erythrocytes; nutrition; oxidation; prostaglandins;     Show all 10 Subjects
Abstract:
... This study evaluated changes in fatty acids from sera, red blood cells, and colonic biopsies from a phase Ib clinical trial of personalized ω-3 fatty acid dosing in 47 healthy volunteers. The trial aimed to reduce colonic prostaglandin E₂ (PGE₂), a pro-inflammatory product of arachidonic acid (AA) oxidation. The personalized doses ranged 2–10 grams/day (54% eicosapentaenoic acid, EPA, 24% other ω- ...
DOI:
10.1080/01635581.2021.1903950

17. Inhibition of Δ-6 desaturase reduces fatty acid re-esterification in 3T3-L1 adipocytes independent of changes in n3-PUFA cellular content

Author:
Chenxuan Wang; Brittany MacIntyre; David M. Mutch
Source:
Biochimica et biophysica acta 2022 v.1867 no.7 pp. 159160
ISSN:
1388-1981
Subject:
omega-3 fatty acids,   etc   ; adipocytes; body fat; body weight; docosapentaenoic acid; eicosapentaenoic acid; enzymes; glycerol; lipolysis; triacylglycerols;     Show all 10 Subjects
Abstract:
... Δ-6 desaturase (D6D) is a key enzyme in the synthesis of long-chain polyunsaturated fatty acids (LC-PUFA). Evidence suggests that reduced D6D activity not only disrupts LC-PUFA production, but also impacts whole body lipid handling and body weight; however, the mechanisms remain largely unexplored. Therefore, we investigated the effect of D6D inhibition on the regulation of lipid accumulation in 3 ...
DOI:
10.1016/j.bbalip.2022.159160

18. Dietary and Plasma Phospholipid Profiles in Vegans and Omnivores—Results from the RBVD Study

Author:
Juliane Menzel; Alessa Longree; Klaus Abraham; Matthias B. Schulze; Cornelia Weikert
Source:
Nutrients 2022 v.14 no.14 pp. -
ISSN:
2072-6643
Subject:
omega-3 fatty acids,   etc   ; fat intake; food intake; omega-6 fatty acids; phospholipids; risk; vegan diet; Germany;     Show all 8 Subjects
Abstract:
... Over the last few years, the vegan diet has become increasingly popular in Germany. It has been proposed that this diet is generally lower in fat, but less is known about the impact on fatty acid (FA) profiles. Therefore, the cross-sectional “Risks and Benefits of a Vegan Diet” (RBVD) study (n = 72) was used to investigate dietary FA intake as well as plasma phospholipid FA in vegans (n = 36) comp ...
DOI:
10.3390/nu14142900

19. OxInflammation at High Altitudes: A Proof of Concept from the Himalayas

Author:
Simona Mrakic-Sposta; Denise Biagini; Danilo Bondi; Tiziana Pietrangelo; Alessandra Vezzoli; Tommaso Lomonaco; Fabio Di Francesco; Vittore Verratti
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
omega-3 fatty acids,   etc   ; adults; altitude; antioxidants; hypoxia; inflammation; neopterin; oxidative stress; prostaglandins; urine; Himalayan region; Nepal;     Show all 12 Subjects
Abstract:
... High-altitude locations are fascinating for investigating biological and physiological responses in humans. In this work, we studied the high-altitude response in the plasma and urine of six healthy adult trekkers, who participated in a trek in Nepal that covered 300 km in 19 days along a route in the Kanchenjunga Mountain and up to a maximum altitude of 5140 m. Post-trek results showed an unbalan ...
DOI:
10.3390/antiox11020368

20. Assessment of Eicosapentaenoic Acid (EPA) Production from Filamentous Microalga Tribonema aequale: From Laboratory to Pilot-Scale Study

Author:
Jijian Long; Jing Jia; Yingchun Gong; Danxiang Han; Qiang Hu
Source:
Marine drugs 2022 v.20 no.6 pp. -
ISSN:
1660-3397
Subject:
omega-3 fatty acids,   etc   ; Tribonema; biomass; coproducts; dewatering; eicosapentaenoic acid; fish oils; glass; microalgae; microbial contamination; photobioreactors;     Show all 11 Subjects
Abstract:
... It has long been explored to use EPA-rich unicellular microalgae as a fish oil alternative for production of the high-value omega-3 fatty acid eicosapentaenoic acid (EPA, 20:5, n-3). However, none of the efforts have ever reached commercial success. This study reported a filamentous yellow-green microalga Tribonema aequale that possesses the ability to grow rapidly and synthesize significant amoun ...
DOI:
10.3390/md20060343