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- Author:
- Conlon, Caroline; Grant, Conor; Tuite, Helen; Fleming, Catherine; Slattery, Eoin
- Source:
- Parasitology international 2021 v.81 pp. 102249
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Echinococcus granulosus; echinococcosis; humans; Ireland; Show all 5 Subjects
- Abstract:
- ... Cystic echinococcosis (CE) is caused by the cestodes of the Echinococcus granulosus sensu lato complex and, in the majority of cases, is associated with hepatic or pulmonary involvement. Human CE is not thought to be endemic in Ireland. We describe the first reported case of human CE possibly acquired in Ireland. ...
- DOI:
- 10.1016/j.parint.2020.102249
- https://dx.doi.org/10.1016/j.parint.2020.102249
- Author:
- Nema, Shrikant; Verma, Anil Kumar; Tiwari, Archana; Bharti, Praveen Kumar
- Source:
- Trends in parasitology 2021 v.37 no.2 pp. 96-99
- ISSN:
- 1471-4922
- Subject:
- parasitology, etc ; health services; malaria; monitoring; India; Show all 5 Subjects
- Abstract:
- ... In the rural and tribal areas of India, poor healthcare services for malaria are posing a great challenge to malaria control and elimination. Digitisation in malaria healthcare services, including surveillance, diagnosis, and treatment, may be helpful in malaria control and, subsequently, may move towards the elimination goal of India by 2030. ...
- DOI:
- 10.1016/j.pt.2020.11.002
- https://dx.doi.org/10.1016/j.pt.2020.11.002
- Author:
- Le Govic, Yohann; Gourbal, Benjamin; Boissier, Jérôme
- Source:
- Trends in parasitology 2021 v.37 no.1 pp. 6-8
- ISSN:
- 1471-4922
- Subject:
- parasitology, etc ; Schistosoma; genes; pathogenesis; praziquantel; schistosomiasis; Show all 6 Subjects
- Abstract:
- ... Efforts to eliminate schistosomiasis are hindered by incomplete efficacy of the only FDA-approved antischistosomal drug, praziquantel. By using postgenomic technologies, Wendt et al. and Wang et al. deciphered the function of several genes required for worm survival and pathogenesis, which opens the way for the development of innovative parasite-targeted therapies. ...
- DOI:
- 10.1016/j.pt.2020.10.010
- https://dx.doi.org/10.1016/j.pt.2020.10.010
- Author:
- van der Pluijm, Rob W.; Amaratunga, Chanaki; Dhorda, Mehul; Dondorp, Arjen M.
- Source:
- Trends in parasitology 2021 v.37 no.1 pp. 15-24
- ISSN:
- 1471-4922
- Subject:
- parasitology, etc ; Plasmodium falciparum; artemisinin; drug resistance; falciparum malaria; Show all 5 Subjects
- Abstract:
- ... Recent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-based combination therapies have shown reduced efficacy in some countries in the GMS at some point. Novel drugs are not a ...
- DOI:
- 10.1016/j.pt.2020.09.011
- https://dx.doi.org/10.1016/j.pt.2020.09.011
- Author:
- Eiras, Jorge; Zhu, Xing-Quan; Yurlova, Natalia; Pedrassani, Daniela; Yoshikawa, Masahide; Nawa, Yukifumi
- Source:
- Parasitology international 2021 v.81 pp. 102269
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Nematoda; definitive hosts; diagnostic techniques; epidemiology; geographical distribution; humans; infection; parasites; prevalence; research; Show all 11 Subjects
- Abstract:
- ... A comprehensive review of the infection of mammals with the nematode Dioctophyme renale (Goeze, 1782) (Nematoda, Dioctophymidae) is presented. Mammals, including man, are the definitive hosts for this parasite. Several aspects of the infection with the parasite in mammals other than humans are critically evaluated: geographical distribution, host species recorded so far and the relative importance ...
- DOI:
- 10.1016/j.parint.2020.102269
- https://dx.doi.org/10.1016/j.parint.2020.102269
- Author:
- Fukuda, Naoyuki; Tachibana, Shin-Ichiro; Ikeda, Mie; Sakurai-Yatsushiro, Miki; Balikagala, Betty; Katuro, Osbert T.; Yamauchi, Masato; Emoto, Sakurako; Hashimoto, Muneaki; Yatsushiro, Shouki; Sekihara, Makoto; Mori, Toshiyuki; Hirai, Makoto; Opio, Walter; Obwoya, Paul S.; Auma, Mary A.; Anywar, Denis A.; Kataoka, Masatoshi; Palacpac, Nirianne M.Q.; Odongo-Aginya, Emmanuel I.; Kimura, Eisaku; Ogwang, Martin; Horii, Toshihiro; Mita, Toshihiro
- Source:
- Parasitology international 2021 v.81 pp. 102277
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Plasmodium falciparum; alleles; area; chloroquine; malaria; monitoring; multiple drug resistance; mutation; quinine; therapeutics; Uganda; Show all 12 Subjects
- Abstract:
- ... In Uganda, artemether-lumefantrine was introduced as an artemisinin-based combination therapy (ACT) for malaria in 2006. We have previously reported a moderate decrease in ex vivo efficacy of lumefantrine in Northern Uganda, where we also detected ex vivo artemisinin-resistant Plasmodium falciparum. Therefore, it is necessary to search for candidate partner alternatives for ACT. Here, we investiga ...
- DOI:
- 10.1016/j.parint.2020.102277
- https://dx.doi.org/10.1016/j.parint.2020.102277
- Author:
- Soo, O.Y.M.; Tan, W.B.
- Source:
- Parasitology international 2021 v.81 pp. 102282
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Arius; Monogenea; catfish; classification; corolla; females; males; monophyly; new species; nucleotide sequences; penis; Malaysia; Show all 13 Subjects
- Abstract:
- ... Hamatopeduncularia longiangusticirrata sp. nov. and H. petalumvaginata sp. nov. were collected from Arius maculatus and Nemapteryx caelata, respectively from Tanjung Karang, Peninsular Malaysia. Morphological and molecular investigations were carried out to ascertain the identity of the new species. The two new species differ from previously described Hamatopeduncularia species in the morphology o ...
- DOI:
- 10.1016/j.parint.2021.102282
- https://dx.doi.org/10.1016/j.parint.2021.102282
- Author:
- El-Sayed, Shimaa Abd El-Salam; Rizk, Mohamed Abdo; Ringo, Aaron Edmond; Li, Yongchang; Liu, Mingming; Ji, Shengwei; Li, Jixu; Byamukama, Benedicto; Tumwebaze, Maria A.; Xuan, Xuenan; Igarashi, Ikuo
- Source:
- Parasitology international 2021 v.81 pp. 102260
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Babesia bovis; babesiosis; fluorescence; in vitro studies; mice; parasites; pyronaridine; therapeutics; Show all 9 Subjects
- Abstract:
- ... The inhibitory efficacies of pyronaridine tetraphosphate (PYR), when used in combination with two novel and potent antibabesial drugs; clofazimine (CF), and MMV396693 were evaluated in the current study against the growth of Babesia bovis, B. caballi, and B. gibsoni in vitro and B. microti in mice. The in vitro study against the selected parasites was performed using combination of PYR with either ...
- DOI:
- 10.1016/j.parint.2020.102260
- https://dx.doi.org/10.1016/j.parint.2020.102260
- Author:
- Leesombun, Arpron; Iijima, Masatomi; Pagmadulam, Baldorj; Orkhon, Banzragchgarav; Doi, Hiroyasu; Issiki, Kunio; Sawa, Ryuichi; Nihei, Coh-ichi; Nishikawa, Yoshifumi
- Source:
- Parasitology international 2021 v.81 pp. 102267
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Metarhizium; Plasmodium falciparum; artemisinin; chloroquine; death; drug resistance; erythrocytes; fungi; lead; optical isomers; parasites; strains; Show all 13 Subjects
- Abstract:
- ... Metacytofilin (MCF) was isolated from the fungus Metarhizium sp. TA2759. Although MCF possesses anti-Toxoplasma activity, the effects of this compound against other parasites are unknown. Here, we evaluated the in vitro anti-malarial activity of MCF against the 3D7 strain and the chloroquine-resistant K1 strain of Plasmodium falciparum. The half maximal inhibitory concentrations (IC₅₀) of MCF agai ...
- DOI:
- 10.1016/j.parint.2020.102267
- https://dx.doi.org/10.1016/j.parint.2020.102267
- Author:
- Ramos, Patrícia Karla Santos; Gonçalves, Lucas Pantoja; Alves, Ana Camila Oliveira; Casseb, Samir Mansour; Lima, Luciana Vieira do Rêgo; Campos, Marliane Batista; Vasconcelos dos Santos, Thiago; Silveira, Fernando Tobias
- Source:
- Parasitology international 2021 v.81 pp. 102273
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; DNA; Leishmania; area; assays; evolution; extraction; humans; infection; monitoring; sampling; sediments; urine; visceral leishmaniasis; Amazonia; Show all 15 Subjects
- Abstract:
- ... The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infections in the Brazilian Amazon has been defined using DTH/IFAT-IgG immune assays and the clinical statuses of infected individuals, revealing five profiles: three asymptomatic [Asymptomatic Infection (AI), Subclinical Resistant Infection (SRI), and Indeterminate Initial Infection (III)], and two symptomatic profiles ...
- DOI:
- 10.1016/j.parint.2020.102273
- https://dx.doi.org/10.1016/j.parint.2020.102273
- Author:
- Wit, Janneke; Dilks, Clayton M.; Andersen, Erik C.
- Source:
- Trends in parasitology 2021 v.37 no.3 pp. 240-250
- ISSN:
- 1471-4922
- Subject:
- parasitology, etc ; Caenorhabditis elegans; Haemonchus contortus; anthelmintics; experimental design; mechanism of action; nematode infections; Show all 7 Subjects
- Abstract:
- ... Anthelmintic drugs are the major line of defense against parasitic nematode infections, but the arsenal is limited and resistance threatens sustained efficacy of the available drugs. Discoveries of the modes of action of these drugs and mechanisms of resistance have predominantly come from studies of a related nonparasitic nematode species, Caenorhabditis elegans, and the parasitic nematode Haemon ...
- DOI:
- 10.1016/j.pt.2020.11.008
- https://dx.doi.org/10.1016/j.pt.2020.11.008
- Author:
- Pham, Thao-Thy; Lamb, Tracey J.; Deroost, Katrien; Opdenakker, Ghislain; Van den Steen, Philippe E.
- Source:
- Trends in parasitology 2021 v.37 no.3 pp. 226-239
- ISSN:
- 1471-4922
- Subject:
- parasitology, etc ; Plasmodium; degradation; hemoglobin; immune response; immunomodulators; isolation techniques; malaria; parasites; variability; virulence; Show all 11 Subjects
- Abstract:
- ... Plasmodium parasites contain various virulence factors that modulate the host immune response. Malarial pigment, or hemozoin (Hz), is an undegradable crystalline product of the hemoglobin degradation pathway in the parasite and possesses immunomodulatory properties. An association has been found between Hz accumulation and severe malaria, suggesting that the effects of Hz on the host immune respon ...
- DOI:
- 10.1016/j.pt.2020.09.016
- https://dx.doi.org/10.1016/j.pt.2020.09.016
- Author:
- Balouz, Virginia; Bracco, Leonel; Ricci, Alejandro D.; Romer, Guadalupe; Agüero, Fernán; Buscaglia, Carlos A.
- Source:
- Trends in parasitology 2021 v.37 no.3 pp. 214-225
- ISSN:
- 1471-4922
- Subject:
- parasitology, etc ; Chagas disease; Trypanosoma cruzi; antibodies; antigens; cost effectiveness; genetic variation; genotyping; parasites; population structure; strains; Show all 11 Subjects
- Abstract:
- ... Trypanosoma cruzi, the protozoan agent of Chagas' disease, displays a complex population structure made up of multiple strains showing a diverse ecoepidemiological distribution. Parasite genetic variability may be associated with disease outcome, hence stressing the need to develop methods for T. cruzi typing in vivo. Serological typing methods that exploit the presence of host antibodies raised a ...
- DOI:
- 10.1016/j.pt.2020.12.002
- https://dx.doi.org/10.1016/j.pt.2020.12.002
- Author:
- Dupont, Damien; Fricker-Hidalgo, Hélène; Brenier-Pinchart, Marie-Pierre; Garnaud, Cécile; Wallon, Martine; Pelloux, Hervé
- Source:
- Trends in parasitology 2021 v.37 no.3 pp. 205-213
- ISSN:
- 1471-4922
- Subject:
- parasitology, etc ; Toxoplasma; administrative management; comorbidity; diagnostic techniques; hematopoietic stem cells; patients; physicians; serology; toxoplasmosis; Show all 10 Subjects
- Abstract:
- ... Toxoplasmosis represents one of the most common comorbidity factors in solid organ or hematopoietic stem cell transplant recipients as well as in other immunocompromised patients. In the past decades, availability and performance of molecular tools for the diagnosis or the exclusion of toxoplasmosis in these patients have greatly improved. However, if accurately used, serology remains a complement ...
- DOI:
- 10.1016/j.pt.2020.09.006
- https://dx.doi.org/10.1016/j.pt.2020.09.006
- Author:
- Nyarko, Prince B.; Claessens, Antoine
- Source:
- Trends in parasitology 2021 v.37 no.3 pp. 195-204
- ISSN:
- 1471-4922
- Subject:
- parasitology, etc ; Plasmodium; assets; chronic diseases; forces; infection; malaria; models; mortality; parasites; sampling; Show all 11 Subjects
- Abstract:
- ... The last malaria parasite standing will display effective adaptations to selective forces. While substantial progress has been made in reducing malaria mortality, eradication will require elimination of all Plasmodium parasites, including those in asymptomatic infections. These typically chronic, low-density infections are difficult to detect, yet can persist for months. We argue that asymptomatic ...
- DOI:
- 10.1016/j.pt.2020.09.017
- https://dx.doi.org/10.1016/j.pt.2020.09.017
- Author:
- Caye, Pâmela; Perera, Soliane Carra; Mendes, Cláudia Beatriz de Mello; Sanches, Mariana Cardoso; Salame, Jéssica Paola; Robaldo, Guilherme Ferreira; Brun, Maurício Veloso; Rappeti, Josaine Cristina da Silva
- Source:
- Parasitology international 2021 v.80 pp. 102211
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Nematoda; dogs; females; kidneys; mixed breeds; parasites; parasitism; parasitoses; surgery; ultrasonics; Show all 11 Subjects
- Abstract:
- ... Dioctophymosis is the disease caused by the nematode Dioctophyme renale, normally found parasitizing the right kidney of dogs. The absence of symptoms is frequent in parasitized animals. The surgical procedures are commonly performed to treat this disease. This work describes a case involving a canine with renal and ectopic parasitosis in the abdominal and thoracic regions. A mixed-breed female do ...
- DOI:
- 10.1016/j.parint.2020.102211
- https://dx.doi.org/10.1016/j.parint.2020.102211
- Author:
- Albery, Gregory F.; Becker, Daniel J.
- Source:
- Trends in parasitology 2021 v.37 no.2 pp. 117-129
- ISSN:
- 1471-4922
- Subject:
- parasitology, etc ; animal pathogens; fecundity; hosts; immunity; interspecific variation; life history; mammals; prediction; risk; sampling; zoonoses; Show all 12 Subjects
- Abstract:
- ... Because most emerging human pathogens originate in mammals, many studies aim to identify host traits that determine the risk of sourcing zoonotic outbreaks. Studies regularly assert that 'fast-lived' mammal species exhibiting greater fecundity and shorter lifespans tend to host more zoonoses; however, the causes of this association remain poorly understood and they cover a range of immune and noni ...
- DOI:
- 10.1016/j.pt.2020.10.012
- https://dx.doi.org/10.1016/j.pt.2020.10.012
- Author:
- Haouas, Najoua; Alharazi, Talal; Al Rasheedi, Asma Obaid; Zreiq, Rafat; Algahtani, Fahad
- Source:
- Parasitology international 2021 v.80 pp. 102208
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Cryptosporidium; Protozoa; cross-sectional studies; feces; hookworms; intestines; parasitoses; prevalence; public health; risk; Saudi Arabia; Show all 12 Subjects
- Abstract:
- ... Owing to Saudi Arabia's high-income economy many Saudi families hire foreign housemaids. However, since the housemaids are potential carriers of intestinal parasites, hiring them increases the risk of transmission to the Saudi community. In this context, this study aimed to evaluate the prevalence of intestinal parasitic infections in foreign housemaids in northwestern Saudi Arabia. Using direct w ...
- DOI:
- 10.1016/j.parint.2020.102208
- https://dx.doi.org/10.1016/j.parint.2020.102208
- Author:
- Katsuno, Kei
- Source:
- Parasitology international 2021 v.80 pp. 102232
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Japan; diagnostic techniques; disease prevention; funding; humans; infectious diseases; nonprofit corporations; pharmaceutical industry; technology; vaccines; Show all 11 Subjects
- Abstract:
- ... The global fight against infectious diseases, both emerging and re-emerging, endures. Japan's commitments and reputation as a good global citizen and its responsibility to uphold domestic and international human security mean that it is in Japan's best interest to leverage its innovative and technological capabilities for global infectious disease prevention and control. The Global Health Innovati ...
- DOI:
- 10.1016/j.parint.2020.102232
- https://dx.doi.org/10.1016/j.parint.2020.102232
- Author:
- Machín, Laura; Nápoles, Rachel; Gille, Lars; Monzote, Lianet
- Source:
- Parasitology international 2021 v.80 pp. 102218
- ISSN:
- 1383-5769
- Subject:
- parasitology, etc ; Leishmania amazonensis; adverse effects; amastigotes; animal models; artemisinin; cutaneous leishmaniasis; mice; parasite load; parasites; Show all 10 Subjects
- Abstract:
- ... The worldwide presence of Leishmania parasites increases in the poorest regions. Current leishmaniasis treatments are unsatisfactory due to resistance development, side effects and cost. Herein, we describe the in vitro activity of artemisinin (ART), artemether (ATM), artesunate (ATS) and dihydroartemisinin (DHA) against Leishmania amazonensis. Selected compounds were assayed in the animal model o ...
- DOI:
- 10.1016/j.parint.2020.102218
- https://dx.doi.org/10.1016/j.parint.2020.102218