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1. Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective

Author:
Ombra, Maria Neve; Paliogiannis, Panagiotis; Stucci, Luigia Stefania; Colombino, Maria; Casula, Milena; Sini, Maria Cristina; Manca, Antonella; Palomba, Grazia; Stanganelli, Ignazio; Mandalà, Mario; Gandini, Sara; Lissia, Amelia; Doneddu, Valentina; Cossu, Antonio; Palmieri, Giuseppe
Source:
Nutrition & metabolism 2019 v.16 no.1 pp. 33
ISSN:
1743-7075
Subject:
pathogenesis,   etc   ; attitudes and opinions; melanoma; nutrition; patients;     Show all 5 Subjects
Abstract:
... Cutaneous malignant melanoma is a heterogeneous disease, being the consequence of specific genetic alterations along several molecular pathways. Despite the increased knowledge about the biology and pathogenesis of melanoma, the incidence has grown markedly worldwide, making it extremely important to develop preventive measures. The beneficial role of correct nutrition and of some natural dietary ...
DOI:
10.1186/s12986-019-0365-4

2. Differential contribution of the two waves of cardiac progenitors and their derivatives to aorta and pulmonary artery

Author:
Jin, Hengwei; Wang, Huijuan; Li, Jie; Yu, Shan; Xu, Mingjie; Qiu, Zhiqian; Xia, Meng; Zhu, Jingai; Feng, Qiuting; Xie, Jun; Xu, Biao; Yang, Zhongzhou
Source:
Developmental biology 2019 v.450 no.2 pp. 82-89
ISSN:
0012-1606
Subject:
pathogenesis,   etc   ; aorta; heart; mice; pulmonary artery;     Show all 5 Subjects
Abstract:
... During mouse development, part of the cells derived from the second heart field (SHF) progenitors contributes to the elongation and enlargement of the outflow tract (OFT) that subsequently septates into the trunks of aorta (Ao) and pulmonary artery (PA). Thus, the cardiac progenitor-originated cells are distributed to both Ao and PA. Here, we investigated that how these cells are assigned to the t ...
DOI:
10.1016/j.ydbio.2019.03.019

3. Update on pathogenesis, diagnosis, and treatment of atopic dermatitis in dogs

Author:
Nuttall, Timothy J.; Marsella, Rosanna; Rosenbaum, Michele R.; Gonzales, Andrea J.; Fadok, Valerie A.
Source:
Journal of the American Veterinary Medical Association 2019 v.254 no.11 pp. 1291-1300
ISSN:
0003-1488
Subject:
pathogenesis,   etc   ; atopic dermatitis; dogs; etiology; inflammation;     Show all 5 Subjects
Abstract:
... Improved understanding of the pathogenesis of atopic dermatitis in dogs has led to more effective treatment plans, including skin barrier repair and new targeted treatments for management of allergy-associated itch and inflammation. The intent of this review article is to provide an update on the etiologic rationale behind current recommendations that emphasize a multimodal approach for the manage ...
DOI:
10.2460/javma.254.11.1291

4. Correction to: Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions

Author:
Miao, Chenggui; Xie, Zhongwen; Chang, Jun
Source:
Biochemical genetics 2018 v.56 no.5 pp. 450
ISSN:
0006-2928
Subject:
pathogenesis,   etc   ; fatty liver; microRNA;     Show all 3 Subjects
Abstract:
... The original version of this article unfortunately contained an error in the Acknowledgement section. The corrected text has been given below: ...
DOI:
10.1007/s10528-018-9874-5

5. Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain

Author:
Stenvang, Marcel; Schafer, Nicholas P.; Malmos, Kirsten Gade; Pérez, Adriana-Michelle Wolf; Niembro, Olatz; Sormanni, Pietro; Basaiawmoit, Rajiv Vaid; Christiansen, Gunna; Andreasen, Maria; Otzen, Daniel E.
Source:
Journal of molecular biology 2018 v.430 pp. 1116-1140
ISSN:
0022-2836
Subject:
pathogenesis,   etc   ; bioinformatics; cornea; mutation; solubility;     Show all 5 Subjects
Abstract:
... Numerous mutations in the corneal protein TGFBIp lead to opaque extracellular deposits and corneal dystrophies (CDs). Here we elucidate the molecular origins underlying TGFBIp's mutation-induced increase in aggregation propensity through comprehensive biophysical and bioinformatic analyses of mutations associated with every major subtype of TGFBIp-linked CDs including lattice corneal dystrophy (LC ...
DOI:
10.1016/j.jmb.2018.03.001

6. The role of complement in antibody mediated transplant rejection

Author:
Thurman, Joshua M.; Panzer, Sarah E.; Le Quintrec, Moglie
Source:
Molecular immunology 2019 v.112 pp. 240-246
ISSN:
0161-5890
Subject:
pathogenesis,   etc   ; allografting; antibodies; antigens; complement; drugs; graft rejection; patients; risk;     Show all 9 Subjects
Abstract:
... Antibody mediated transplant rejection (AMR) is a major cause of long-term allograft failure, and currently available treatments are of limited efficacy for treating the disease. AMR is caused by donor specific antibodies (DSA) that bind to antigens within the transplanted organ. DSA usually activate the classical pathway of complement within the allograft, and complement activation is believed to ...
DOI:
10.1016/j.molimm.2019.06.002

7. Gene polymorphism and risk of idiopathic membranous nephropathy

Author:
Liu, Dongwei; Zhang, Jiahui; Shi, Yan; Liu, Zhangsuo
Source:
Life sciences 2019 v.229 pp. 124-131
ISSN:
0024-3205
Subject:
pathogenesis,   etc   ; genes; genetic factors; genetic polymorphism; kidney diseases; patients; risk;     Show all 7 Subjects
Abstract:
... Membranous nephropathy (MN) is the most common primary glomerular disease (PGD) in the world. Currently, MN still lacks specific diagnostic markers and effective treatment strategy. It is speculated that the occurrence of MN is mainly related to environmental and genetic factors. The pathological manifestations of MN patients are diverse, significant differences in response to treatment options, a ...
DOI:
10.1016/j.lfs.2019.05.010

8. The correlation between intestinal dysbiosis and the development of ankylosing spondylitis

Author:
Zhang, Lilong; Hu, Yuqi; Xu, Yao; Li, Pengfei; Ma, Hong; Li, Xia; Li, Ming
Source:
Microbial pathogenesis 2019 v.132 pp. 188-192
ISSN:
0882-4010
Subject:
pathogenesis,   etc   ; dysbiosis; genetic factors; intestinal microorganisms; intestines; mucosal immunity; patients;     Show all 7 Subjects
Abstract:
... The pathogenesis and development of ankylosing spondylitis (AS) is concealed and complicated. In recent years, alterations in gut microbiota of AS patients have been largely investigated, although the underlying mechanisms remain unclear. This article reviews the recent studies on changes of gut microbiota in AS patients, and discusses the possible correlation between intestinal dysbiosis and AS d ...
DOI:
10.1016/j.micpath.2019.04.038

9. Airborne particulate size and concentrations in five Thoroughbred training yards in Newmarket (UK)

Author:
Davison, Joshua A.; Wylie, Claire E.; McGladdery, Charles E.; Fettes, Connor; Haggett, Emily F.; Ramzan, Pieter H.L.
Source:
The veterinary journal 2019 v.248 pp. 48-50
ISSN:
1090-0233
Subject:
pathogenesis,   etc   ; Thoroughbred; aerodynamics; inflammation; particulates; racehorses; summer; winter; United Kingdom;     Show all 9 Subjects
Abstract:
... Despite their implication in the pathogenesis of lower airway inflammation, limited baseline data exists for airborne particulates in Thoroughbred racehorse stalls in the United Kingdom. This study documents airborne particulate size and concentrations in Newmarket training yards using a nephelometer (DustTrak DRX 8534, TSI). Each stall was sampled on a summer and winter day at three time points ( ...
DOI:
10.1016/j.tvjl.2019.04.006

10. Alpha-enolase staining patterns in the renal tissues of cats with and without chronic kidney disease

Author:
McLeland, Shannon; Quimby, Jessica; Lappin, Michael R.
Source:
Veterinary immunology and immunopathology 2019 v.212 pp. 23-26
ISSN:
0165-2427
Subject:
pathogenesis,   etc   ; cats; epithelium; histopathology; immunohistochemistry; nephritis; phosphopyruvate hydratase; staining;     Show all 8 Subjects
Abstract:
... Renal α-enolase has variable expression in inflammatory and neoplastic diseases. Therefore, in order to define the distribution of α-enolase in renal tissues of cats, an immunohistochemistry assay was validated and described here. Tissues from 29 cats with IRIS Stage 2–4 CKD, 8 control cats < 2 years of age, and 4 control cats> 10 years of age were assessed. Interstitial nephritis was the predomin ...
DOI:
10.1016/j.vetimm.2019.04.009

11. Function of secreted phospholipase A2 group-X in asthma and allergic disease

Author:
Nolin, James D.; Murphy, Ryan C.; Gelb, Michael H.; Altemeier, William A.; Henderson, William R.; Hallstrand, Teal S.
Source:
Biochimica et biophysica acta 2019 v.1864 no.6 pp. 827-837
ISSN:
1388-1981
Subject:
pathogenesis,   etc   ; animal models; asthma; eicosanoids; humans; inflammation; leukocytes; phospholipase A2;     Show all 8 Subjects
Abstract:
... Elevated secreted phospholipase A2 (sPLA2) activity in the airways has been implicated in the pathogenesis of asthma and allergic disease for some time. The identity and function of these enzymes in asthma is becoming clear from work in our lab and others. We focused on sPLA2 group X (sPLA2-X) after identifying increased levels of this enzyme in asthma, and that it is responsible for a large porti ...
DOI:
10.1016/j.bbalip.2018.11.009

12. Biofilms in Chronic Wounds: Pathogenesis and Diagnosis

Author:
Wu, Yuan-Kun; Cheng, Nai-Chen; Cheng, Chao-Min
Source:
Trends in biotechnology 2019 v.37 no.5 pp. 505-517
ISSN:
0167-7799
Subject:
pathogenesis,   etc   ; biofilm; microbiology; point-of-care systems; transcriptomics;     Show all 5 Subjects
Abstract:
... Chronic non-healing wounds have become a major worldwide healthcare burden. The impact of biofilms on chronic wound infection is well established. Despite increasing understanding of the underlying mechanism of biofilm formation in chronic wounds, current strategies for biofilm diagnosis in chronic wounds are still far from ideal. In this review, we briefly summarize the mechanism of biofilm forma ...
DOI:
10.1016/j.tibtech.2018.10.011

13. The evolution of collective infectious units in viruses

Author:
Leeks, Asher; Sanjuán, Rafael; West, Stuart A.
Source:
Virus research 2019 v.265 pp. 94-101
ISSN:
0168-1702
Subject:
pathogenesis,   etc   ; evolution; genome; hosts; models; packaging; virion; virus replication; viruses;     Show all 9 Subjects
Abstract:
... Viruses frequently spread among cells or hosts in groups, with multiple viral genomes inside the same infectious unit. These collective infectious units can consist of multiple viral genomes inside the same virion, or multiple virions inside a larger structure such as a vesicle. Collective infectious units deliver multiple viral genomes to the same cell simultaneously, which can have important imp ...
DOI:
10.1016/j.virusres.2019.03.013

14. Unveiling the Mutational Mechanism of the Bacterial Genotoxin Colibactin in Colorectal Cancer

Author:
Thakur, Bhupesh K.; Malaisé, Yann; Martin, Alberto
Source:
Molecular cell 2019 v.74 no.2 pp. 227-229
ISSN:
1097-2765
Subject:
pathogenesis,   etc   ; DNA adducts; bacteria; colorectal neoplasms; genotoxicity; mutagens;     Show all 6 Subjects
Abstract:
... In a recent issue of Science, Wilson et al. (2019) provide direct evidence that the bacterial-produced colibactin alkylates DNA in vivo, resulting in DNA adducts, which mediates its genotoxic effect. This work reinforces the role of colibactin-producing bacteria in colon cancer pathogenesis. ...
DOI:
10.1016/j.molcel.2019.04.007

15. The relevance of pyroptosis in the pathogenesis of liver diseases

Author:
Guo, Huiting; Xie, Mingjie; Zhou, Cheng; Zheng, Min
Source:
Life sciences 2019 v.223 pp. 69-73
ISSN:
0024-3205
Subject:
pathogenesis,   etc   ; cytokines; hosts; liver diseases; programmed cell death;     Show all 5 Subjects
Abstract:
... Pyroptosis is a novel programmed cell death form which is distinct from other types of cell death. As an inherently inflammatory process, it plays a vital role in cellular lysis and release of pro-inflammatory cytokines when hosts defend against infections. Recent studies have reported that pyroptosis was involved in liver diseases and had important functions in the progress and development of liv ...
DOI:
10.1016/j.lfs.2019.02.060

16. Progress and Challenges for Live-cell Imaging of Genomic Loci Using CRISPR-based Platforms

Author:
Wu, Xiaotian; Mao, Shiqi; Ying, Yachen; Krueger, Christopher J.; Chen, Antony K.
Source:
Genomics, proteomics & bioinformatics 2019 v.17 no.2 pp. 119-128
ISSN:
1672-0229
Subject:
pathogenesis,   etc   ; chromatin; fluorescence; gene editing; genomics; image analysis; loci; physiology;     Show all 8 Subjects
Abstract:
... Chromatin conformation, localization, and dynamics are crucial regulators of cellular behaviors. Although fluorescence in situ hybridization-based techniques have been widely utilized for investigating chromatin architectures in healthy and diseased states, the requirement for cell fixation precludes the comprehensive dynamic analysis necessary to fully understand chromatin activities. This has sp ...
DOI:
10.1016/j.gpb.2018.10.001

17. Sarcomere variants in arrhythmogenic cardiomyopathy: Pathogenic factor or bystander?

Author:
Chen, Kai; Rao, Man; Guo, Guangran; Chen, Xiao; Chen, Liang; Song, Jiangping
Source:
Gene 2019 v.687 pp. 82-89
ISSN:
0378-1119
Subject:
pathogenesis,   etc   ; cardiomyopathy; genes; inheritance (genetics); mutation; patients; pedigree; sarcomeres; screening;     Show all 9 Subjects
Abstract:
... Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease, which is mainly caused by desmosomal mutations. Sarcomere variants were the primary genetic basis of hypertrophic cardiomyopathy (HCM) and were recently detected in arrhythmogenic cardiomyopathy (ACM). Our aim is to seek potential pathogenic variants of sarcomere genes in our ACM cohort and describe their characteristics.We ...
DOI:
10.1016/j.gene.2018.10.080

18. Advances in detection and quantification of methylcytosine and its derivatives

Author:
Asenso, James; Wang, Liang; Du, Yan; Liu, Qing‐hua; Xu, Bing‐ju; Guo, Meng‐zhe; Tang, Dao‐quan
Source:
Journal of separation science 2019 v.42 no.5 pp. 1105-1116
ISSN:
1615-9306
Subject:
pathogenesis,   etc   ; DNA; blood; carbon; cytosine; epigenetics; methylation; prognosis; urine;     Show all 9 Subjects
Abstract:
... Methylation of the fifth carbon atom in cytosine is an epigenetic modification of deoxyribonucleic acid that plays important roles in numerous cellular processes and disease pathogenesis. Three additional states of cytosine, that is, 5‐hydroxymethylcytosine, 5‐formylcytosine and 5‐carboxylcytosine, have been identified and associated with the diagnosis and/or prognosis of diseases. However, accura ...
DOI:
10.1002/jssc.201801100

19. Stable Intronic Sequence RNAs (sisRNAs): An Expanding Universe

Author:
Chan, Seow Neng; Pek, Jun Wei
Source:
Trends in biochemical sciences 2019 v.44 no.3 pp. 258-272
ISSN:
0968-0004
Subject:
pathogenesis,   etc   ; DNA; genes; homeostasis; humans; non-coding RNA; protein content;     Show all 7 Subjects
Abstract:
... Intronic sequences are often regarded as ‘nonsense’ transcripts that are rapidly degraded. We highlight here recent studies on intronic sequences that play regulatory roles as long noncoding RNAs (lncRNAs) which are classified as sisRNAs. Interestingly, sisRNAs come in different forms and are produced via a variety of ways. They regulate genes at the DNA, RNA, and protein levels, and frequently en ...
DOI:
10.1016/j.tibs.2018.09.016

20. Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B

Author:
Chen, Peng; Tao, Liang; Liu, Zheng; Dong, Min; Jin, Rongsheng
Source:
TheFEBS journal 2019 v.286 no.5 pp. 874-881
ISSN:
1742-464X
Subject:
pathogenesis,   etc   ; Clostridium difficile; epithelium; humans; morbidity; mortality; receptors; therapeutics; virulence;     Show all 9 Subjects
Abstract:
... The incidence of Clostridium difficile infection (CDI) has increased significantly worldwide, causing substantial morbidity and mortality. One of the major virulence factor, TcdB, manages to enter the colonic epithelia via the human frizzled proteins (FZDs), which are physiological receptors for Wnt morphogens. Binding of TcdB to FZDs inhibits Wnt signaling, which may contribute to pathogenesis of ...
DOI:
10.1111/febs.14681