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... Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these malformations in recent years. This review summarize known molecular and embryological precursors for ...
pathogenesis; pathogenesis-related proteins, etc ; Fusarium wilt; Musa; bananas; genes; genome-wide association study; Show all 7 Subjects
Abstract:
... Pathogenesis related protein-1 (PR-1) is the most abundantly produced protein during defense response against many biotic and abiotic stresses. However, knowledge on PR-1 gene family and its evolutionary relationship in banana is very limited. In order to study the potential role of PR-1 genes in banana, genome wide identification, structure analysis and expressions were performed. A total of 15 a ...
pathogenesis, etc ; fluorescence; lysosomes; mitochondria; Show all 4 Subjects
Abstract:
... We constructed two fluorescent probes for monitoring H₂O₂ in the mitochondria and lysosomes. Fluorescence imaging reveals that mitochondrial H₂O₂ mediates reduced GCase activity in lysosomes in the brains of mice with depression. This work provides a powerful tool for understanding the pathogenesis of depression. ...
... microRNAs are non-coding molecules, approximately 22 nucleotides in length, that regulate various cellular processes. A growing body of evidence has suggested that their dysregulated expression is involved in the pathogenesis of diverse diseases, including diabetes mellitus type 2 (DM2). Early onset of this chronic and complex metabolic disorder is frequently undiagnosed, leading to the developmen ...
... As the major energy supplier in cells, mitochondria play a significant role in regulating cellular processes. The pathogenesis of various diseases is found to be associated with dysfunctional mitochondria, and supplement of functional mitochondria has been regarded as a potential therapeutic strategy. To achieve mitochondrial replenishment, transplantation of isolated mitochondria or utilization o ...
... Viral aggregation is a complex and pervasive phenomenon affecting many viral families. An increasing number of studies have indicated that it can modulate critical parameters surrounding viral infections, and yet its role in viral infectivity, pathogenesis, and evolution is just beginning to be appreciated. Aggregation likely promotes viral infection by increasing the cellular multiplicity of infe ...
... The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its str ...
pathogenesis, etc ; Protozoa; metabolism; neurotransmitters; parasitology; Show all 5 Subjects
Abstract:
... γ-aminobutyric acid (GABA) is a nonstructural amino acid that serves diverse functions in unicellular and multicellular organisms. Besides its widely established role in mammals as an inhibitory neurotransmitter, the diverse biological roles and metabolism of GABA in protozoan parasites have begun to be unveiled. GABA acts as either the intracellular signal or cell-to-cell messenger to mediate a v ...
pathogenesis, etc ; arthritis; protein-tyrosine-phosphatase; Show all 3 Subjects
Abstract:
... Mutations in the adaptor protein PSTPIP1 cause a spectrum of autoinflammatory diseases, including PAPA and PAMI; however, the mechanism underlying these diseases remains unknown. Most of these mutations lie in PSTPIP1 F-BAR domain, which binds to LYP, a protein tyrosine phosphatase associated with arthritis and lupus. To shed light on the mechanism by which these mutations generate autoinflammator ...
pathogenesis, etc ; RNA; biosynthesis; databases; ribonucleotides; Show all 5 Subjects
Abstract:
... To date, over 150 different RNA modifications have been identified, playing crucial roles in biological processes and disease pathogenesis. Thanks to the advancement of high-throughput sequencing technologies employed for transcriptome-wide mapping, a bunch of RNA modification databases have emerged as an exciting area, which promotes further investigation of the mechanisms and functions of these ...
Advait Balaji; Bryce Kille; Anthony D. Kappell; Gene D. Godbold; Madeline Diep; R. A. Leo Elworth; Zhiqin Qian; Dreycey Albin; Daniel J. Nasko; Nidhi Shah; Mihai Pop; Santiago Segarra; Krista L. Ternus; Todd J. Treangen
... The COVID-19 pandemic has emphasized the importance of accurate detection of known and emerging pathogens. However, robust characterization of pathogenic sequences remains an open challenge. To address this need we developed SeqScreen, which accurately characterizes short nucleotide sequences using taxonomic and functional labels and a customized set of curated Functions of Sequences of Concern (F ...
pathogenesis, etc ; Clostridium difficile; cortex; spore germination; Show all 4 Subjects
Abstract:
... Germination by Clostridioides difficile spores is an essential step in pathogenesis. Spores are metabolically dormant forms of bacteria that resist severe conditions. Work over the last 10 years has elucidated that C. difficile spores germinate thorough a novel pathway. This review summarizes our understanding of C. difficile spore germination and the factors involved in germinant recognition, cor ...
pathogenesis, etc ; gene expression; neurons; prioritization; viruses; Show all 5 Subjects
Abstract:
... A signature trait of neurotropic α-herpesviruses (α-HV) is their ability to establish stable non-productive infections of peripheral neurons termed latency. This specialized gene expression program is the foundation of an evolutionarily successful strategy to ensure lifelong persistence in the host. Various physiological stresses can induce reactivation in a subset of latently-infected neurons all ...
pathogenesis, etc ; heart failure; therapeutics; veterinary medicine; Show all 4 Subjects
Abstract:
... The treatment of chronic congestive heart failure (CHF), secondary to myxomatous mitral valve disease (MMVD) in dogs, has considerably changed in the last fifty years. An analysis of the literature concerning the therapy of chronic CHF in dogs affected by MMVD is not available, and it is needed. Narrative reviews (NRs) are aimed at identifying and summarizing what has been previously published, av ...
pathogenesis, etc ; Rotavirus; antiviral agents; luciferase; microRNA; Show all 5 Subjects
Abstract:
... The significance of the Wnt/β-catenin signaling cascade in Rotavirus (RV) infection has not been elucidated. In this study, we attempt to elucidate the importance of the Wnt/β-catenin pathway in the RV pathogenesis and investigate a miRNA-mediated approach to regulate the pathway to repress the RV infection in the host. The regulation of the Wnt signaling pathway in terms of β-catenin accumulation ...
pathogenesis, etc ; antibiotic resistance; biofilm; environmental DNA; Show all 4 Subjects
Abstract:
... Bacterial biofilms contribute significantly to the antibiotic resistance, pathogenesis, chronicity and recurrence of bacterial infections. Critical to the stability and survival of extant biofilms is the extracellular DNA (eDNA)-dependent matrix which shields the resident bacteria from hostile environments, allows a sessile metabolic state, but also encourages productive interactions with biofilm- ...
pathogenesis, etc ; biofilm; drugs; immune system; plankton; Show all 5 Subjects
Abstract:
... Biofilm is the trigger for the majority of infections caused by the ability of microorganisms to adhere to tissues and medical devices. Microbial cells embedded in the biofilm matrix are highly tolerant to antimicrobials and escape the host immune system. Thus, the refractory nature of biofilm-related infections (BRIs) still represents a great challenge for physicians and is a serious health threa ...
pathogenesis, etc ; human health; microRNA; parasites; parasitology; Show all 5 Subjects
Abstract:
... Parasitic diseases are still the common diseases that seriously threaten human health and life, and a better understanding of host–parasite interactions is the key to effectively controlling and ultimately eradicating these diseases. MicroRNAs (miRNAs) are ubiquitously expressed in almost all eukaryotic parasites and their hosts. These regulatory noncoding RNAs can be released by donor cells and a ...
pathogenesis, etc ; coevolution; commensalism; immune system; microbiome; Show all 5 Subjects
Abstract:
... Back-and-forth intercommunication in host–pathogen interactions has long been recognized to play an important role in commensalism and microbial pathogenesis. For centuries, we have studied these microbes in our surroundings, yet many questions about the evolutionary cross-talk between host and microbe remain unanswered. With the recent surge in research interest in the commensal microbiome, basic ...
pathogenesis, etc ; DNA; analytical chemistry; artificial intelligence; exosomes; Show all 5 Subjects
Abstract:
... The sensitive and accurate analysis of exosomes is of great significance because they contain the original bioactive molecules of their parent cells, which are closely associated with the pathogenesis of various diseases. Among various technologies developed for the detection of exosomes, the ones integrated with functional nucleic acid (FNA)-based signal amplification strategies have emerged to b ...