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You searched for: Subject "pathogenesis" Remove constraint Subject: "pathogenesis"
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1. Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy

Author:
Su Yeon Lee; Emma Grace Loll; Abd-Elrahman Said Hassan; Mingyu Cheng; Aijun Wang; Diana Lee Farmer
Source:
Journal of developmental biology 2022 v.10 no.1 pp. -
ISSN:
2221-3759
Subject:
pathogenesis,   etc   ; genes; therapeutics;     Show all 3 Subjects
Abstract:
... Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these malformations in recent years. This review summarize known molecular and embryological precursors for ...
DOI:
10.3390/jdb10010011

2. Genome-wide analysis of pathogenesis-related protein 1 (PR-1) gene family from Musa spp. and its role in defense response during stresses

Author:
Chelliah Anuradha; Arumugam Chandrasekar; Suthanthiram Backiyarani; Raman Thangavelu; Palaniappan Giribabu; Subbaraya Uma
Source:
Gene 2022 v.821 pp. 146334
ISSN:
0378-1119
Subject:
pathogenesis; pathogenesis-related proteins,   etc   ; Fusarium wilt; Musa; bananas; genes; genome-wide association study;     Show all 7 Subjects
Abstract:
... Pathogenesis related protein-1 (PR-1) is the most abundantly produced protein during defense response against many biotic and abiotic stresses. However, knowledge on PR-1 gene family and its evolutionary relationship in banana is very limited. In order to study the potential role of PR-1 genes in banana, genome wide identification, structure analysis and expressions were performed. A total of 15 a ...
DOI:
10.1016/j.gene.2022.146334

3. In situ fluorescence imaging reveals that mitochondrial H₂O₂ mediates lysosomal dysfunction in depression

Author:
Xin Wang; Qi Ding; Ying Tian; Wei Wu; Feida Che; Ping Li; Wen Zhang; Wei Zhang; Bo Tang
Source:
Chemical communications 2022 v.58 no.43 pp. 6320-6323
ISSN:
1364-548X
Subject:
pathogenesis,   etc   ; fluorescence; lysosomes; mitochondria;     Show all 4 Subjects
Abstract:
... We constructed two fluorescent probes for monitoring H₂O₂ in the mitochondria and lysosomes. Fluorescence imaging reveals that mitochondrial H₂O₂ mediates reduced GCase activity in lysosomes in the brains of mice with depression. This work provides a powerful tool for understanding the pathogenesis of depression. ...
DOI:
10.1039/d2cc00431c

4. Circulating miRNA as potential biomarkers for diabetes mellitus type 2: should we focus on searching for sex differences?

Author:
Weronika Kraczkowska; Lucyna Stachowiak; Andrzej Pławski; Paweł Piotr Jagodziński
Source:
Journal of applied genetics 2022 v.63 no.2 pp. 293-303
ISSN:
1234-1983
Subject:
pathogenesis,   etc   ; biomarkers; microRNA; nucleotides;     Show all 4 Subjects
Abstract:
... microRNAs are non-coding molecules, approximately 22 nucleotides in length, that regulate various cellular processes. A growing body of evidence has suggested that their dysregulated expression is involved in the pathogenesis of diverse diseases, including diabetes mellitus type 2 (DM2). Early onset of this chronic and complex metabolic disorder is frequently undiagnosed, leading to the developmen ...
DOI:
10.1007/s13353-021-00678-5

5. Targeted mitochondrial delivery: A therapeutic new era for disease treatment

Author:
Ting Huang; Tianyuan Zhang; Jianqing Gao
Source:
Journal of controlled release 2022 v.343 pp. 89-106
ISSN:
0168-3659
Subject:
pathogenesis,   etc   ; energy; mitochondria; therapeutics;     Show all 4 Subjects
Abstract:
... As the major energy supplier in cells, mitochondria play a significant role in regulating cellular processes. The pathogenesis of various diseases is found to be associated with dysfunctional mitochondria, and supplement of functional mitochondria has been regarded as a potential therapeutic strategy. To achieve mitochondrial replenishment, transplantation of isolated mitochondria or utilization o ...
DOI:
10.1016/j.jconrel.2022.01.025

6. Viral Aggregation: The Knowns and Unknowns

Author:
Swechchha Pradhan; Arvind Varsani; Chloe Leff; Carter J. Swanson; Rizal F. Hariadi
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
pathogenesis,   etc   ; evolution; therapeutics; virulence;     Show all 4 Subjects
Abstract:
... Viral aggregation is a complex and pervasive phenomenon affecting many viral families. An increasing number of studies have indicated that it can modulate critical parameters surrounding viral infections, and yet its role in viral infectivity, pathogenesis, and evolution is just beginning to be appreciated. Aggregation likely promotes viral infection by increasing the cellular multiplicity of infe ...
DOI:
10.3390/v14020438

7. The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine

Author:
Sara J. Lawrence-Mills; David Hughes; Melanie J. Hezzell; Matthew Butler; Chris Neal; Rebecca R. Foster; Gavin I. Welsh; Natalie Finch
Source:
veterinary journal 2022 v.285 pp. 105843
ISSN:
1090-0233
Subject:
pathogenesis,   etc   ; humans; veterinary medicine;     Show all 3 Subjects
Abstract:
... The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its str ...
DOI:
10.1016/j.tvjl.2022.105843

8. Physiological roles and metabolism of γ-aminobutyric acid (GABA) in parasitic protozoa

Author:
Rivo Yudhinata Brian Nugraha; Ghulam Jeelani; Tomoyoshi Nozaki
Source:
Trends in parasitology 2022 v.38 no.6 pp. 462-477
ISSN:
1471-4922
Subject:
pathogenesis,   etc   ; Protozoa; metabolism; neurotransmitters; parasitology;     Show all 5 Subjects
Abstract:
... γ-aminobutyric acid (GABA) is a nonstructural amino acid that serves diverse functions in unicellular and multicellular organisms. Besides its widely established role in mammals as an inhibitory neurotransmitter, the diverse biological roles and metabolism of GABA in protozoan parasites have begun to be unveiled. GABA acts as either the intracellular signal or cell-to-cell messenger to mediate a v ...
DOI:
10.1016/j.pt.2022.02.004

9. PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders

Author:
José A. Manso; Tamara Marcos; Virginia Ruiz-Martín; Javier Casas; Pablo Alcón; Mariano Sánchez Crespo; Yolanda Bayón; José M. de Pereda; Andrés Alonso
Source:
Cellular and molecular life sciences 2022 v.79 no.2 pp. 131
ISSN:
1420-682X
Subject:
pathogenesis,   etc   ; arthritis; protein-tyrosine-phosphatase;     Show all 3 Subjects
Abstract:
... Mutations in the adaptor protein PSTPIP1 cause a spectrum of autoinflammatory diseases, including PAPA and PAMI; however, the mechanism underlying these diseases remains unknown. Most of these mutations lie in PSTPIP1 F-BAR domain, which binds to LYP, a protein tyrosine phosphatase associated with arthritis and lupus. To shed light on the mechanism by which these mutations generate autoinflammator ...
DOI:
10.1007/s00018-022-04173-w

10. A brief review of RNA modification related database resources

Author:
Jiani Ma; Lin Zhang; Shutao Chen; Hui Liu
Source:
Methods 2022 v.203 pp. 342-353
ISSN:
1046-2023
Subject:
pathogenesis,   etc   ; RNA; biosynthesis; databases; ribonucleotides;     Show all 5 Subjects
Abstract:
... To date, over 150 different RNA modifications have been identified, playing crucial roles in biological processes and disease pathogenesis. Thanks to the advancement of high-throughput sequencing technologies employed for transcriptome-wide mapping, a bunch of RNA modification databases have emerged as an exciting area, which promotes further investigation of the mechanisms and functions of these ...
DOI:
10.1016/j.ymeth.2021.03.003

11. SeqScreen: accurate and sensitive functional screening of pathogenic sequences via ensemble learning

Author:
Advait Balaji; Bryce Kille; Anthony D. Kappell; Gene D. Godbold; Madeline Diep; R. A. Leo Elworth; Zhiqin Qian; Dreycey Albin; Daniel J. Nasko; Nidhi Shah; Mihai Pop; Santiago Segarra; Krista L. Ternus; Todd J. Treangen
Source:
Genome biology 2022 v.23 no.1 pp. 133
ISSN:
1474-760X
Subject:
pathogenesis,   etc   ; COVID-19 infection; genome; models;     Show all 4 Subjects
Abstract:
... The COVID-19 pandemic has emphasized the importance of accurate detection of known and emerging pathogens. However, robust characterization of pathogenic sequences remains an open challenge. To address this need we developed SeqScreen, which accurately characterizes short nucleotide sequences using taxonomic and functional labels and a customized set of curated Functions of Sequences of Concern (F ...
DOI:
10.1186/s13059-022-02695-x

12. Clostridioides difficile spore germination: initiation to DPA release

Author:
Marko Baloh; Joseph A Sorg
Source:
Current opinion in microbiology 2022 v.65 pp. 101-107
ISSN:
1369-5274
Subject:
pathogenesis,   etc   ; Clostridium difficile; cortex; spore germination;     Show all 4 Subjects
Abstract:
... Germination by Clostridioides difficile spores is an essential step in pathogenesis. Spores are metabolically dormant forms of bacteria that resist severe conditions. Work over the last 10 years has elucidated that C. difficile spores germinate thorough a novel pathway. This review summarizes our understanding of C. difficile spore germination and the factors involved in germinant recognition, cor ...
DOI:
10.1016/j.mib.2021.11.001

13. Impact of Cultured Neuron Models on α-Herpesvirus Latency Research

Author:
Angus C. Wilson
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
pathogenesis,   etc   ; gene expression; neurons; prioritization; viruses;     Show all 5 Subjects
Abstract:
... A signature trait of neurotropic α-herpesviruses (α-HV) is their ability to establish stable non-productive infections of peripheral neurons termed latency. This specialized gene expression program is the foundation of an evolutionarily successful strategy to ensure lifelong persistence in the host. Various physiological stresses can induce reactivation in a subset of latently-infected neurons all ...
DOI:
10.3390/v14061209

14. Management of Chronic Congestive Heart Failure Caused by Myxomatous Mitral Valve Disease in Dogs: A Narrative Review from 1970 to 2020

Author:
Mara Bagardi; Viola Zamboni; Chiara Locatelli; Alberto Galizzi; Sara Ghilardi; Paola G. Brambilla
Source:
Animals 2022 v.12 no.2 pp. -
ISSN:
2076-2615
Subject:
pathogenesis,   etc   ; heart failure; therapeutics; veterinary medicine;     Show all 4 Subjects
Abstract:
... The treatment of chronic congestive heart failure (CHF), secondary to myxomatous mitral valve disease (MMVD) in dogs, has considerably changed in the last fifty years. An analysis of the literature concerning the therapy of chronic CHF in dogs affected by MMVD is not available, and it is needed. Narrative reviews (NRs) are aimed at identifying and summarizing what has been previously published, av ...
DOI:
10.3390/ani12020209

15. Rotavirus-Mediated Suppression of miRNA-192 Family and miRNA-181a Activates Wnt/β-Catenin Signaling Pathway: An In Vitro Study

Author:
Anwesha Banerjee; Mamta Chawla-Sarkar; Anupam Mukherjee
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
pathogenesis,   etc   ; Rotavirus; antiviral agents; luciferase; microRNA;     Show all 5 Subjects
Abstract:
... The significance of the Wnt/β-catenin signaling cascade in Rotavirus (RV) infection has not been elucidated. In this study, we attempt to elucidate the importance of the Wnt/β-catenin pathway in the RV pathogenesis and investigate a miRNA-mediated approach to regulate the pathway to repress the RV infection in the host. The regulation of the Wnt signaling pathway in terms of β-catenin accumulation ...
DOI:
10.3390/v14030558

16. Bacterial Biofilms Utilize an Underlying Extracellular DNA Matrix Structure That Can Be Targeted for Biofilm Resolution

Author:
Steven D. Goodman; Lauren O. Bakaletz
Source:
Microorganisms 2022 v.10 no.2 pp. -
ISSN:
2076-2607
Subject:
pathogenesis,   etc   ; antibiotic resistance; biofilm; environmental DNA;     Show all 4 Subjects
Abstract:
... Bacterial biofilms contribute significantly to the antibiotic resistance, pathogenesis, chronicity and recurrence of bacterial infections. Critical to the stability and survival of extant biofilms is the extracellular DNA (eDNA)-dependent matrix which shields the resident bacteria from hostile environments, allows a sessile metabolic state, but also encourages productive interactions with biofilm- ...
DOI:
10.3390/microorganisms10020466

17. The Current Knowledge on the Pathogenesis of Tissue and Medical Device-Related Biofilm Infections

Author:
Enea Gino Di Domenico; Alessandra Oliva; María Guembe
Source:
Microorganisms 2022 v.10 no.7 pp. -
ISSN:
2076-2607
Subject:
pathogenesis,   etc   ; biofilm; drugs; immune system; plankton;     Show all 5 Subjects
Abstract:
... Biofilm is the trigger for the majority of infections caused by the ability of microorganisms to adhere to tissues and medical devices. Microbial cells embedded in the biofilm matrix are highly tolerant to antimicrobials and escape the host immune system. Thus, the refractory nature of biofilm-related infections (BRIs) still represents a great challenge for physicians and is a serious health threa ...
DOI:
10.3390/microorganisms10071259

18. Host–parasite interactions mediated by cross-species microRNAs

Author:
Xing He; Weiqing Pan
Source:
Trends in parasitology 2022 v.38 no.6 pp. 478-488
ISSN:
1471-4922
Subject:
pathogenesis,   etc   ; human health; microRNA; parasites; parasitology;     Show all 5 Subjects
Abstract:
... Parasitic diseases are still the common diseases that seriously threaten human health and life, and a better understanding of host–parasite interactions is the key to effectively controlling and ultimately eradicating these diseases. MicroRNAs (miRNAs) are ubiquitously expressed in almost all eukaryotic parasites and their hosts. These regulatory noncoding RNAs can be released by donor cells and a ...
DOI:
10.1016/j.pt.2022.02.011

19. The Study of Microbe–Host Two-Way Communication

Author:
Famatta Perry; Ryan J. Arsenault
Source:
Microorganisms 2022 v.10 no.2 pp. -
ISSN:
2076-2607
Subject:
pathogenesis,   etc   ; coevolution; commensalism; immune system; microbiome;     Show all 5 Subjects
Abstract:
... Back-and-forth intercommunication in host–pathogen interactions has long been recognized to play an important role in commensalism and microbial pathogenesis. For centuries, we have studied these microbes in our surroundings, yet many questions about the evolutionary cross-talk between host and microbe remain unanswered. With the recent surge in research interest in the commensal microbiome, basic ...
DOI:
10.3390/microorganisms10020408

20. Recent advances in exosome analysis assisted by functional nucleic acid-based signal amplification technologies

Author:
Qinya Feng; Wenjiao Fan; Wei Ren; Chenghui Liu
Source:
Trends in analytical chemistry 2022 v.149 pp. 116549
ISSN:
0165-9936
Subject:
pathogenesis,   etc   ; DNA; analytical chemistry; artificial intelligence; exosomes;     Show all 5 Subjects
Abstract:
... The sensitive and accurate analysis of exosomes is of great significance because they contain the original bioactive molecules of their parent cells, which are closely associated with the pathogenesis of various diseases. Among various technologies developed for the detection of exosomes, the ones integrated with functional nucleic acid (FNA)-based signal amplification strategies have emerged to b ...
DOI:
10.1016/j.trac.2022.116549