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1. The Biology of Physiological Health

Author:
Ayres, Janelle S.
Source:
Cell 2020 v.181 no.2 pp. 250-269
ISSN:
0092-8674
Subject:
pathogenesis,   etc   ; disease resistance; vigor;     Show all 3 Subjects
Abstract:
... The ability to maintain health, or recover to a healthy state after disease, is an active process involving distinct adaptation mechanisms coordinating interactions between all physiological systems of an organism. Studies over the past several decades have assumed the mechanisms of health and disease are essentially inter-changeable, focusing on the elucidation of the mechanisms of disease pathog ...
DOI:
10.1016/j.cell.2020.03.036

2. Roadmap for the Emerging Field of Cancer Neuroscience

Author:
Monje, Michelle; Borniger, Jeremy C.; D’Silva, Nisha J.; Deneen, Benjamin; Dirks, Peter B.; Fattahi, Faranak; Frenette, Paul S.; Garzia, Livia; Gutmann, David H.; Hanahan, Douglas; Hervey-Jumper, Shawn L.; Hondermarck, Hubert; Hurov, Jonathan B.; Kepecs, Adam; Knox, Sarah M.; Lloyd, Alison C.; Magnon, Claire; Saloman, Jami L.; Segal, Rosalind A.; Sloan, Erica K.; Sun, Xin; Taylor, Michael D.; Tracey, Kevin J.; Trotman, Lloyd C.; Tuveson, David A.; Wang, Timothy C.; White, Ruth A.; Winkler, Frank
Source:
Cell 2020 v.181 no.2 pp. 219-222
ISSN:
0092-8674
Subject:
pathogenesis,   etc   ; neoplasms; nervous system; neurophysiology;     Show all 4 Subjects
Abstract:
... Mounting evidence indicates that the nervous system plays a central role in cancer pathogenesis. In turn, cancers and cancer therapies can alter nervous system form and function. This Commentary seeks to describe the burgeoning field of “cancer neuroscience” and encourage multidisciplinary collaboration for the study of cancer-nervous system interactions. ...
DOI:
10.1016/j.cell.2020.03.034

3. A More Granular View of Neutrophils in Malaria

Author:
Amulic, Borko; Moxon, Christopher A.; Cunnington, Aubrey J.
Source:
Trends in parasitology 2020 v.36 no.6 pp. 501-503
ISSN:
1471-4922
Subject:
pathogenesis,   etc   ; Plasmodium; immunity; inflammation; malaria; neutrophils;     Show all 6 Subjects
Abstract:
... Neutrophils are abundant innate immune cells with crucial roles in immunity and vascular inflammation. Recent evidence indicates that neutrophils have a dual role in malaria, contributing to both pathogenesis and control of Plasmodium. We discuss emerging mechanisms behind these opposing functions and identify key outstanding questions. ...
DOI:
10.1016/j.pt.2020.03.003

4. Comparative genomics in infectious disease

Author:
Moustafa, Ahmed M; Lal, Arnav; Planet, Paul J
Source:
Current opinion in microbiology 2020 v.53 pp. 61-70
ISSN:
1369-5274
Subject:
pathogenesis,   etc   ; databases; genomics; infectious diseases; nucleotide sequences;     Show all 5 Subjects
Abstract:
... With more than one million bacterial genome sequences uploaded to public databases in the last 25 years, genomics has become a powerful tool for studying bacterial biology. Here, we review recent approaches that leverage large numbers of whole genome sequences to decipher the spread and pathogenesis of bacterial infectious diseases. ...
DOI:
10.1016/j.mib.2020.02.009

5. CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset

Author:
Lee, Jong-Min; Correia, Kevin; Loupe, Jacob; Kim, Kyung-Hee; Barker, Douglas; Hong, Eun Pyo; Chao, Michael J.; Long, Jeffrey D.; Lucente, Diane; Vonsattel, Jean Paul G.; Pinto, Ricardo Mouro; Abu Elneel, Kawther; Ramos, Eliana Marisa; Mysore, Jayalakshmi Srinidhi; Gillis, Tammy; Wheeler, Vanessa C.; MacDonald, Marcy E.; Gusella, James F.; McAllister, Branduff; Massey, Thomas; Medway, Christopher; Stone, Timothy C.; Hall, Lynsey; Jones, Lesley; Holmans, Peter; Kwak, Seung; Ehrhardt, Anka G.; Sampaio, Cristina; Ciosi, Marc; Maxwell, Alastair; Chatzi, Afroditi; Monckton, Darren G.; Orth, Michael; Landwehrmeyer, G. Bernhard; Paulsen, Jane S.; Dorsey, E. Ray; Shoulson, Ira; Myers, Richard H.
Source:
Cell 2019 v.178 no.4 pp. 887-900.e14
ISSN:
0092-8674
Subject:
pathogenesis,   etc   ; DNA; genes; loci;     Show all 4 Subjects
Abstract:
... Variable, glutamine-encoding, CAA interruptions indicate that a property of the uninterrupted HTT CAG repeat sequence, distinct from the length of huntingtin’s polyglutamine segment, dictates the rate at which Huntington’s disease (HD) develops. The timing of onset shows no significant association with HTT cis-eQTLs but is influenced, sometimes in a sex-specific manner, by polymorphic variation at ...
DOI:
10.1016/j.cell.2019.06.036
PubMed:
31398342
PubMed Central:
PMC6700281

6. Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent Mycobacteria Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in Mycobacterium tuberculosis Pathogenesis

Author:
Choudhary, Eira; Bullen, C. Korin; Goel, Renu; Singh, Alok Kumar; Praharaj, Monali; Thakur, Preeti; Dhiman, Rohan; Bishai, William R.; Agarwal, Nisheeth
Source:
Journal of proteome research 2020 v.19 no.6 pp. 2316-2336
ISSN:
1535-3907
Subject:
pathogenesis,   etc   ; Mycobacterium tuberculosis; RNA; data collection; macrophages; phosphoproteome; virulence;     Show all 7 Subjects
Abstract:
... Comparative phosphoproteomics of Mycobacterium tuberculosis (Mtb)- and Mycobacterium bovis BCG (BCG)-infected macrophages could be instrumental in understanding the characteristic post-translational modifications of host proteins and their subsequent involvement in determining Mtb pathogenesis. To identify proteins acquiring a distinct phosphorylation status, herein, we compared the phosphorylatio ...
DOI:
10.1021/acs.jproteome.9b00895

7. Autophagy in Astrocytes and its Implications in Neurodegeneration

Author:
Sung, Katherine; Jimenez-Sanchez, Maria
Source:
Journal of molecular biology 2020 v.432 no.8 pp. 2605-2621
ISSN:
0022-2836
Subject:
pathogenesis,   etc   ; astrocytes; autophagosomes; autophagy; lysosomes; neurodegenerative diseases; neurons; proteins;     Show all 8 Subjects
Abstract:
... Autophagy is a major degradation pathway where double-membrane vesicles called autophagosomes deliver cytoplasmic content to the lysosome. Increasing evidence suggests that autophagy dysfunction contributes to the pathogenesis of neurodegenerative diseases. In addition, misfolded proteins that accumulate in these diseases and constitute a common pathological hallmark are substrates for autophagic ...
DOI:
10.1016/j.jmb.2019.12.041

8. James Robert Alfano, A Giant in Phytopathogenic Bacteria Effector Biology

Author:
Collmer, Alan
Source:
Molecular plant-microbe interactions 2020 v.33 no.3 pp. 377-381
ISSN:
0894-0282
Subject:
pathogenesis,   etc   ; Pseudomonas syringae; host-pathogen relationships; plant pathogenic bacteria;     Show all 4 Subjects
Abstract:
... The worldwide molecular plant-microbe interactions research community was significantly diminished in November 2019 by the death of James “Jim” Robert Alfano at age 56. Jim was a giant in our field, who gained key insights into plant pathogenesis using the model bacterial pathogen Pseudomonas syringae. As a mentor, collaborator, and, above all, a friend, I know Jim’s many dimensions and accomplish ...
DOI:
10.1094/MPMI-12-19-0354-CR

9. Integrative Model to Coordinate the Oligomerization and Aggregation Mechanisms of CCL5

Author:
Chen, Yi-Chen; Chen, Siou-Pei; Li, Jin-Ye; Chen, Pei-Chun; Lee, Yi-Zong; Li, Kun-Mou; Zarivach, Raz; Sun, Yuh-Ju; Sue, Shih-Che
Source:
Journal of molecular biology 2020 v.432 no.4 pp. 1143-1157
ISSN:
0022-2836
Subject:
pathogenesis,   etc   ; chemokine CCL5; models; mutants; nuclear magnetic resonance spectroscopy; oligomerization;     Show all 6 Subjects
Abstract:
... CC-type chemokine ligand 5 (CCL5) is involved in the pathogenesis of many inflammatory conditions. Under physiological conditions, CCL5 oligomerization and aggregation are considered to be responsible for its inflammatory properties. The structural basis of CCL5 oligomerization remains controversial because the current oligomer models contain no consensus interactions. In this study, NMR and bioph ...
DOI:
10.1016/j.jmb.2019.12.049

10. SnapShot: Lysosomal Storage Diseases

Author:
Martina, José A.; Raben, Nina; Puertollano, Rosa
Source:
Cell 2020 v.180 no.3 pp. 602
ISSN:
0092-8674
Subject:
pathogenesis,   etc   ; homeostasis; inherited metabolic diseases; lysosomes; proteins; therapeutics;     Show all 6 Subjects
Abstract:
... Lysosomal storage diseases (LSDs) represent a group of monogenic inherited metabolic disorders characterized by the progressive accumulation of undegraded substrates inside lysosomes, resulting in aberrant lysosomal activity and homeostasis. This SnapShot summarizes the intracellular localization and function of proteins implicated in LSDs. Common aspects of LSD pathogenesis and the major current ...
DOI:
10.1016/j.cell.2020.01.017

11. Specificity of gut microbiota in children with autism spectrum disorder in Slovakia and its correlation with astrocytes activity marker and specific behavioural patterns

Author:
Tomova, A.; Soltys, K.; Repiska, G.; Palkova, L.; Filcikova, D.; Minarik, G.; Turna, J.; Prochotska, K.; Babinska, K.; Ostatnikova, D.
Source:
Physiology & behavior 2020 v.214 pp. 112745
ISSN:
0031-9384
Subject:
pathogenesis,   etc   ; astrocytes; autism; children; gastrointestinal system; inflammation; intestinal microorganisms; Slovakia;     Show all 8 Subjects
Abstract:
... Recent research suggests the involvement of bidirectional gut-brain axis in autism spectrum disorder (ASD). The aim of this study was to establish the role of changed gut microbiota in behavioural and gastrointestinal manifestations, but also in astrocyte activation in children with ASD. Distinct faecal microbiota in children with ASD was found to be more heterogeneous compared to that in neurotyp ...
DOI:
10.1016/j.physbeh.2019.112745

12. Radiological Evaluation of Juvenile osteochondral Conditions in Brazilian Warmblood Horse

Author:
Gonçalves, Lessana M.; Pozzobon, Ricardo; dos Anjos, Bruno L.; Pellegrini, Débora C.P.; Azevedo, Marcos S.; Dau, Stefano L.; Oliveira, Guilherme P.; Klaus, Rosana
Source:
Journal of equine veterinary science 2020 v.85 pp. 102844
ISSN:
0737-0806
Subject:
pathogenesis,   etc   ; farms; females; foals; juveniles; males; skeleton; Brazil;     Show all 8 Subjects
Abstract:
... The term juvenile osteochondral condition (JOCC) has been used to identify developmental changes in the growth plates. The condition is characterized by a set of changes with similar pathogenesis that affect the immature skeleton and joints of growing foals. The aim of the current study is to investigate the prevalence and degree of severity of osteochondral changes in Brazilian warmblood (BW) foa ...
DOI:
10.1016/j.jevs.2019.102844

13. Preserving single cells in space and time for analytical assays

Author:
Gallion, Luke A.; Anttila, Matthew M.; Abraham, David H.; Proctor, Angela; Allbritton, Nancy L.
Source:
Trends in analytical chemistry 2020 v.122 pp. 115723
ISSN:
0165-9936
Subject:
pathogenesis,   etc   ; cell biology; diagnostic techniques; disease detection; patients;     Show all 5 Subjects
Abstract:
... Analytical assays performed within clinical laboratories influence roughly 70% of all medical decisions by facilitating disease detection, diagnosis, and management. Both in clinical and academic research laboratories, single-cell assays permit measurement of cell diversity and identification of rare cells, both of which are important in the understanding of disease pathogenesis. For clinical util ...
DOI:
10.1016/j.trac.2019.115723
PubMed:
32153309
PubMed Central:
PMC7061724

14. Pathogenesis related proteins: A defensin for plants but an allergen for humans

Author:
Arora, Rahul; Kumar, Amit; Singh, Indrakant Kumar; Singh, Archana
Source:
International journal of biological macromolecules 2020 v.157 pp. 659-672
ISSN:
0141-8130
Subject:
pathogenesis; pathogenesis-related proteins,   etc   ; B-lymphocytes; abiotic stress; allergenicity; allergens; biotic stress; computer simulation; crystal structure; epitopes; fruits; humans; immunoglobulin E; leaves; pollen; prediction;     Show all 16 Subjects
Abstract:
... Pathogenesis related (PR) proteins are defensins expressed upon biotic and abiotic stress by plants. They are also synthesized in specific plant parts such as root, stem, leaves, pollen grains and fruits. According to the current classification, there are 19 different classes of PR-Proteins, 8 out of 19 are proven to exhibit allergic reactions in human. Here, we carried out the allergenicity poten ...
DOI:
10.1016/j.ijbiomac.2019.11.223

15. Colonic mucosal and serum expression of microRNAs in canine large intestinal inflammatory bowel disease

Author:
Konstantinidis, Alexandros Ο.; Pardali, Dimitra; Adamama-Moraitou, Katerina K.; Gazouli, Maria; Dovas, Chrysostomos I.; Legaki, Evangelia; Brellou, Georgia D.; Savvas, Ioannis; Jergens, Albert E.; Rallis, Timoleon S.; Allenspach, Karin
Source:
BMC veterinary research 2020 v.16 no.1 pp. 69
ISSN:
1746-6148
Subject:
pathogenesis,   etc   ; biomarkers; blood serum; dogs; etiology; humans; inflammatory bowel disease; intestines; microRNA; mucosa;     Show all 10 Subjects
Abstract:
... BACKGROUND: Canine inflammatory bowel disease (IBD) is a group of chronic gastrointestinal (GI) disorders of still largely unknown etiology. Canine IBD diagnosis is time-consuming and costly as other diseases with similar signs should be initially excluded. In human IBD microRNA (miR) expression changes have been reported in GI mucosa and blood. Thus, there is a possibility that miRs may provide i ...
DOI:
10.1186/s12917-020-02287-6
PubMed:
32087719
PubMed Central:
PMC7035774

16. Identification of novel human adenovirus candidates using the coxsackievirus and adenovirus receptor for cell entry

Author:
Mese, Kemal; Bunz, Oskar; Schellhorn, Sebastian; Volkwein, Wolfram; Jung, Dominik; Gao, Jian; Zhang, Wenli; Baiker, Armin; Ehrhardt, Anja
Source:
Virology journal 2020 v.17 no.1 pp. 52
ISSN:
1743-422X
Subject:
pathogenesis,   etc   ; Human mastadenovirus C; animal viruses; humans; luciferase; patients; polymerase chain reaction; screening; transgenes; virion; viruses;     Show all 11 Subjects
Abstract:
... BACKGROUND: There are over 100 known human adenovirus (HAdV) types, which are able to cause a broad variety of different self-limiting but also lethal diseases especially in immunocompromised patients. Only limited information about the pathogenesis and biology of the majority of these virus types is available. In the present study, we performed a systematic screen for coxsackievirus and adenoviru ...
DOI:
10.1186/s12985-020-01318-w
PubMed:
32272960
PubMed Central:
PMC7146880

17. Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities

Author:
Yuan, Kai; Zhu, Qingqing; Lu, Qingyi; Jiang, Haixu; Zhu, Mengmeng; Li, Xiaohong; Huang, Guangrui; Xu, Anlong
Source:
The Journal of nutritional biochemistry 2020 v.84 pp. 108454
ISSN:
0955-2863
Subject:
pathogenesis,   etc   ; apoptosis; autophagy; blood plasma; cartilage; chemokines; fruits; inflammation; mice; neutrophils; quercetin; rheumatoid arthritis; therapeutics; vegetables;     Show all 14 Subjects
Abstract:
... Rheumatoid arthritis (RA) is a prototypical autoimmune disorder mainly characterized by joint inflammation and cartilage destruction. Neutrophils actively take part in the initiation and progression of RA. Neutrophils express inflammatory mediators, including cytokines and chemokines. Aberrant formation of neutrophil extracellular traps (NETs) has been demonstrated in the pathogenesis of RA. Thus, ...
DOI:
10.1016/j.jnutbio.2020.108454

18. An efficient hybrid feature selection method to identify potential biomarkers in common chronic lung inflammatory diseases

Author:
Maghsoudloo, Mazaher; Azimzadeh Jamalkandi, Sadegh; Najafi, Ali; Masoudi-Nejad, Ali
Source:
Genomics 2020 v.112 no.5 pp. 3284-3293
ISSN:
0888-7543
Subject:
pathogenesis,   etc   ; asthma; biomarkers; data collection; fibrosis; gene expression regulation; genes; lungs; patients;     Show all 9 Subjects
Abstract:
... Asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) are three serious lung inflammatory diseases. The understanding of the pathogenesis mechanism and the identification of potential prognostic biomarkers of these diseases can provide the patients with more efficient treatments. In this study, an efficient hybrid feature selection method was introduced in o ...
DOI:
10.1016/j.ygeno.2020.06.010

19. Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

Author:
An, Tong-Qing; Li, Jiang-Nan; Su, Chia-Ming; Yoo, Dongwan
Source:
Virus research 2020 v.286 pp. 197980
ISSN:
0168-1702
Subject:
pathogenesis,   etc   ; Porcine reproductive and respiratory syndrome virus; apoptosis; cytokines; financial economics; innate immunity; microRNA; pork industry;     Show all 8 Subjects
Abstract:
... Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral ...
DOI:
10.1016/j.virusres.2020.197980
PubMed:
32311386
PubMed Central:
PMC7165118

20. Whole genome sequence of Diaporthe capsici, a new pathogen of walnut blight

Author:
Fang, Xinmei; Qin, Kai; Li, Shujiang; Han, Shan; Zhu, Tianhui; Fang, Xinmei; Qin, Kai
Source:
Genomics 2020 v.112 no.5 pp. 3751-3761
ISSN:
0888-7543
Subject:
pathogenesis,   etc   ; Diaporthe; blight; databases; fungi; genes; genomics; nucleotide sequences; pathogens; peppers; proteome; transcriptome; virulent strains; walnuts;     Show all 14 Subjects
Abstract:
... Many fungi in the Diaporthe genus across the world are pathogenic. Diaporthe capsici. is a pathogenic fungus that can infect peppers and walnuts, causing their death. The aim of this study was to develop a genomic resource to provide substantial data and a theoretical basis for research on molecular pathogenesis, transcriptome, proteome, and metabonome of D. capsici. The whole genome of D. capsici ...
DOI:
10.1016/j.ygeno.2020.04.018