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1. Gene Function Discovery for Kinetoplastid Pathogens

Author:
Salavati, Reza; Gazestani, Vahid H.
Source:
Trends in parasitology 2019 v.35 no.1 pp. 8-12
ISSN:
1471-4922
Subject:
pathogens,   etc   ; genes; models;     Show all 3 Subjects
Abstract:
... We propose to integrate the existing and new experimental data with computational tools to model interaction networks for the most prominent kinetoplastid pathogens. These interaction networks will vastly expand the functional annotation of the kinetoplastid genomes, which in turn are critical for identifying new routes of disease intervention. ...
DOI:
10.1016/j.pt.2018.09.003

2. Alterations in plant sugar metabolism: signatory of pathogen attack

Author:
Kanwar, Poonam; Jha, Gopaljee
Source:
Planta 2019 v.249 no.2 pp. 305-318
ISSN:
0032-0935
Subject:
host-pathogen relationships; pathogens,   etc   ; enzymes; metabolism; sugars; transporters;     Show all 6 Subjects
Abstract:
... MAIN CONCLUSION: This review summarizes the current understanding, future challenges and ongoing quest on sugar metabolic alterations that influence the outcome of plant–pathogen interactions. Intricate cellular and molecular events occur during plant–pathogen interactions. They cause major metabolic perturbations in the host and alterations in sugar metabolism play a pivotal role in governing the ...
DOI:
10.1007/s00425-018-3018-3

3. Revisiting the Origin of Plant NBS-LRR Genes

Author:
Shao, Zhu-Qing; Xue, Jia-Yu; Wang, Qiang; Wang, Bin; Chen, Jian-Qun
Source:
Trends in plant science 2019 v.24 no.1 pp. 9-12
ISSN:
1360-1385
Subject:
pathogens,   etc   ; Chlorophyta; ancestry; disease resistance; genes;     Show all 5 Subjects
Abstract:
... The NBS-LRR genes are functionally responsible for plant resistance to alien pathogens. Here, we show that NBS-LRR genes originated in the common ancestor of the whole green lineage, and have rapidly diverged into three subclasses with different domain combinations (TNL, CNL, and RNL) before the split of green algae. ...
DOI:
10.1016/j.tplants.2018.10.015

4. Transcriptomic Resources for Parasitic Nematodes of Veterinary Importance

Author:
Jex, Aaron R.; Gasser, Robin B.; Schwarz, Erich M.
Source:
Trends in parasitology 2019 v.35 no.1 pp. 72-84
ISSN:
1471-4922
Subject:
animal pathogens,   etc   ; Nematoda; genomics; parasitism; transcriptome; transcriptomics;     Show all 6 Subjects
Abstract:
... Parasitic nematodes are important pathogens of animals, causing diseases that impact on agricultural production worldwide. Research on these worms has been constrained by a lack of genetic and genomic tools. Nonetheless, over the past decade this field has made substantial advances, many of which have been led by transcriptomic sequencing. The present review summarises major transcriptomic studies ...
DOI:
10.1016/j.pt.2018.09.010

5. The Pathogen–Host Interface in Three Dimensions: Correlative FIB/SEM Applications

Author:
Weiner, Allon; Enninga, Jost
Source:
Trends in microbiology 2019 v.27 no.5 pp. 426-439
ISSN:
0966-842X
Subject:
host-pathogen relationships; pathogens,   etc   ; Brucella; Salmonella; Shigella; fluorescence microscopy; scanning electron microscopy; tomography; ultrastructure;     Show all 9 Subjects
Abstract:
... Pathogens survive and propagate within host cells through a wide array of complex interactions. Tracking the molecular and cellular events by multidimensional fluorescence microscopy has been a widespread tool for research on intracellular pathogens. Through major advancements in 3D electron microscopy, intracellular pathogens can also be visualized in their cellular environment to an unprecedente ...
DOI:
10.1016/j.tim.2018.11.011

6. How toll-like receptors reveal monocyte plasticity: the cutting edge of antiinflammatory therapy

Author:
Ropert, Catherine
Source:
Cellular and molecular life sciences 2019 v.76 no.4 pp. 745-755
ISSN:
1420-682X
Subject:
pathogen-associated molecular patterns; pathogens,   etc   ; Toll-like receptors; homeostasis; immune response; monocytes; therapeutics; tissue repair;     Show all 8 Subjects
Abstract:
... Toll-like receptors (TLR)s are central in immune response by recognizing pathogen-associated molecular patterns (PAMP)s. If they are essential to eliminate pathogens in earlier stages of infection, they also might play a role in homeostasis and tissue repair. TLR versatility parallels the plasticity of monocytes, which represent an heterogeneous population of immune cells. They are rapidly recruit ...
DOI:
10.1007/s00018-018-2959-9

7. Review: Plant immune signaling from a network perspective

Author:
Katagiri, Fumiaki
Source:
Plant science 2018 v.276 pp. 14-21
ISSN:
0168-9452
Subject:
pathogens,   etc   ; immune response; models;     Show all 3 Subjects
Abstract:
... For predictive biology of a large and complex network, important mechanistic information consists of network topology, signal-convergence rules, and signal dynamics. In practice, the key to enabling predictive modeling of a complex network is reducing it sufficiently to allow modeling without omitting important factors affecting network behavior. Here I argue that the plant immune signaling networ ...
DOI:
10.1016/j.plantsci.2018.07.013

8. Therapeutic Opportunities in Intestinal Microbiota–Virus Interactions

Author:
Monedero, Vicente; Collado, María Carmen; Rodríguez-Díaz, Jesús
Source:
Trends in biotechnology 2018 v.36 pp. 645-648
ISSN:
0167-7799
Subject:
pathogens,   etc   ; hosts; microorganisms; therapeutics;     Show all 4 Subjects
Abstract:
... The host microbiota has emerged a third player in interactions between hosts and viral pathogens. This opens new possibilities to use different tools to modulate the intestinal microbial composition, aimed at reducing the risk of or treating viral enteric infections. ...
DOI:
10.1016/j.tibtech.2017.12.009

9. For T Cells, the Child Is Father of the Man

Author:
Hogquist, Kristin A.; Hamilton, Sara E.
Source:
Cell 2018 v.174 no.1 pp. 16-18
ISSN:
0092-8674
Subject:
pathogens,   etc   ; T-lymphocytes; children;     Show all 3 Subjects
Abstract:
... When T cells respond to infectious agents, they differentiate into effector and memory cells. In this issue of Cell, Smith et al. use a genetic “time-stamping” method to show that the developmental time the T cell arises—near birth or as an adult—dictates what type of T effector or memory cell results. ...
DOI:
10.1016/j.cell.2018.06.015

10. Microbial stress meeting: From systems to molecules and back

Author:
Dorey, Amber L.; Giovannercole, Fabio; Guerreiro, Duarte; Marinho, Catarina
Source:
New biotechnology 2019 v.49 pp. 66-70
ISSN:
1871-6784
Subject:
host-pathogen relationships,   etc   ; engineering; evolution; microorganisms; stress response;     Show all 5 Subjects
Abstract:
... The 4th Microbial Stress Meeting: from Systems to Moleculesand Back was held in April 2018 in Kinsale, Ireland. The meeting covered five main topics: 1. Stress at the systems and structural level; 2. Responses to osmotic and acid stress; 3. Stress responses in single cells; 4. Stress in host-pathogen interactions; and 5. Biotechnological optimisation of microorganisms through engineering and evolu ...
DOI:
10.1016/j.nbt.2018.09.002

11. Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection

Author:
Brown, Alistair J.P.; Gow, Neil A.R.; Warris, Adilia; Brown, Gordon D.
Source:
Trends in microbiology 2019 v.27 no.3 pp. 219-230
ISSN:
0966-842X
Subject:
pathogens,   etc   ; dogs; fungi; humans; immune evasion; immunity; lifestyle; memory; prediction;     Show all 9 Subjects
Abstract:
... By analogy with Pavlov’s dogs, certain pathogens have evolved anticipatory behaviours that exploit specific signals in the human host to prepare themselves against imminent host challenges. This adaptive prediction, a type of history-dependent microbial behaviour, represents a primitive form of microbial memory. For fungal pathogens, adaptive prediction helps them circumvent nutritional immunity, ...
DOI:
10.1016/j.tim.2018.11.001

12. Protective cultures against foodborne pathogens in a nitrite reduced fermented meat product

Author:
Nikodinoska, Ivana; Baffoni, Loredana; Di Gioia, Diana; Manso, Beatriz; García-Sánchez, Lourdes; Melero, Beatriz; Rovira, Jordi
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2019 v.101 pp. 293-299
ISSN:
0023-6438
Subject:
food pathogens,   etc   ; Salmonella; chorizo; fermented meat; models; sodium nitrite;     Show all 6 Subjects
Abstract:
... In the present work, a combined hurdle approach for fermented meat preservation was investigated. Challenge tests were performed in Chorizo sausage model using the maximum allowed NaNO2 amount (150 mg/kg), a reduced amount (75 mg/kg) and no nitrite, with and without protective cultures inoculation. Cocktail strains of L. monocytogenes and Salmonella spp. were used as indicator strains. In a nitrit ...
DOI:
10.1016/j.lwt.2018.11.022

13. Transmissible vaccines whose dissemination rates vary through time, with applications to wildlife

Author:
Smithson, Mark W.; Basinki, Andrew J.; Nuismer, Scott L.; Bull, James J.
Source:
Vaccine 2019 v.37 no.9 pp. 1153-1159
ISSN:
0264-410X
Subject:
pathogens,   etc   ; engineering; herd immunity; hosts; humans; viral vaccines; wildlife;     Show all 7 Subjects
Abstract:
... Transmission is a potential property of live viral vaccines that remains largely unexploited but may lie within the realm of many engineering designs. While likely unacceptable for vaccines of humans, transmission may be highly desirable for vaccines of wildlife, both to protect natural populations and also to limit zoonotic transmissions into humans. Defying intuition, transmission alone does not ...
DOI:
10.1016/j.vaccine.2019.01.018

14. Integrated Signaling Pathways Mediate Bordetella Immunomodulation, Persistence, and Transmission

Author:
Gestal, M.C.; Whitesides, L.T.; Harvill, E.T.
Source:
Trends in microbiology 2019 v.27 no.2 pp. 118-130
ISSN:
0966-842X
Subject:
pathogens,   etc   ; Bordetella; bacteria; immune system; immunomodulation; mice; pathogenesis; signal transduction;     Show all 8 Subjects
Abstract:
... The mammalian immune system includes a sophisticated array of antimicrobial mechanisms. However, successful pathogens have developed subversive strategies to detect, modulate, and/or evade immune control and clearance. Independent disciplines study host immunology and bacterial pathogenesis, but interkingdom signaling between bacteria and host during natural infection remains poorly understood. An ...
DOI:
10.1016/j.tim.2018.09.010

15. Nutrient sulfur acquisition strategies employed by bacterial pathogens

Author:
Lensmire, Joshua M; Hammer, Neal D
Source:
Current opinion in microbiology 2019 v.47 pp. 52-58
ISSN:
1369-5274
Subject:
pathogens,   etc   ; bacterial growth; cysteine; metabolites; nutrients; sulfates; sulfur; therapeutics;     Show all 8 Subjects
Abstract:
... Pathogens have evolved elegant mechanisms to acquire essential nutrients from host environments. Sulfur is a requirement for bacterial growth and inorganic and organic sulfur-containing metabolites are abundant within the host–pathogen interface. A growing body of evidence suggests that pathogens are capable of scavenging both types of sulfur sources to fulfill the nutritional requirement. While t ...
DOI:
10.1016/j.mib.2018.11.002

16. Detection of Lotmaria passim in Africanized and European honey bees from Uruguay, Argentina and Chile

Author:
Castelli, Loreley; Branchiccela, Belén; Invernizzi, Ciro; Tomasco, Ivanna; Basualdo, Marina; Rodriguez, Marta; Zunino, Pablo; Antúnez, Karina
Source:
Journal of invertebrate pathology 2019 v.160 pp. 95-97
ISSN:
0022-2011
Subject:
pathogens,   etc   ; Crithidia; honey bees; parasites; parasitism; Argentina; Chile; Uruguay;     Show all 8 Subjects
Abstract:
... Trypanosomatids affecting honey bees, Crithidia mellificae and Lotmaria passim, have been poorly studied in South America. We therefore analyzed their presence in Africanized and European honeybees from Uruguay, Argentina and Chile collected between 1990 and 2011 and assessed their association with other bee parasites and pathogens. Crithidia mellificae was not detected while L. passim was wide-sp ...
DOI:
10.1016/j.jip.2018.11.004

17. Molecular Mechanisms Underlying Microbial Disease Control in Intercropping

Author:
Zhu, Shusheng; Morel, Jean-Benoît
Source:
Molecular plant-microbe interactions 2019 v.32 no.1 pp. 20-24
ISSN:
0894-0282
Subject:
pathogens,   etc   ; disease control; induced resistance; inoculum; intercropping; nutrients; plant protection;     Show all 7 Subjects
Abstract:
... Many reports indicate that intercropping, which usually consists of growing two species next to each other, reduces the incidence of microbial diseases. Besides mechanisms operating at the field level, like inoculum dilution, there is recent evidence that plant-centered mechanisms with identified plant molecules and pathways are also involved. First, plants may trigger the induction of resistance ...
DOI:
10.1094/MPMI-03-18-0058-CR

18. Regulation of Plant Immune Signaling by Calcium-Dependent Protein Kinases

Author:
Bredow, Melissa; Monaghan, Jacqueline
Source:
Molecular plant-microbe interactions 2019 v.32 no.1 pp. 6-19
ISSN:
0894-0282
Subject:
pathogens,   etc   ; calcium; calcium signaling; microorganisms; protein kinases; proteins; stress response;     Show all 7 Subjects
Abstract:
... Activation of Ca²⁺ signaling is a universal response to stress that allows cells to quickly respond to environmental cues. Fluctuations in cytosolic Ca²⁺ are decoded in plants by Ca²⁺-sensing proteins such as Ca²⁺-dependent protein kinases (CDPKs). The perception of microbes results in an influx of Ca²⁺ that activates numerous CDPKs responsible for propagating immune signals required for resistanc ...
DOI:
10.1094/MPMI-09-18-0267-FI

19. First report of Colletotrichum truncatum associated with anthracnose disease on tuberose (Polianthes tuberosa) in India

Author:
Mahadevakumar, S.; Chandana, C.; Janardhana, G.R.
Source:
Crop protection 2019 v.118 pp. 1-5
ISSN:
0261-2194
Subject:
pathogen identification; pathogens,   etc   ; Colletotrichum truncatum; Polianthes tuberosa; anthracnose; conidia; cut flowers; flowers; foliar application; fungi; leaves; oligodeoxyribonucleotides; phylogeny; surveys; India;     Show all 15 Subjects
Abstract:
... Tuberose (Polianthes tuberosa) is an important commercial flower crop grown in Karnataka for its beautiful and fragrant cut flowers. Recently, an association of anthracnose disease (incidence ranged from 18 to 27%) characterized by the dark concentric sunken necrotic lesions with spore mass in the acervuli on leaves and peduncles of Tuberose was observed in a field survey conducted during October ...
DOI:
10.1016/j.cropro.2018.12.006

20. The planarian Schmidtea mediterranea is a new model to study host-pathogen interactions during fungal infections

Author:
Maciel, Eli Isael; Jiang, Cen; Barghouth, Paul G.; Nobile, Clarissa J.; Oviedo, Néstor J.
Source:
Developmental and comparative immunology 2019 v.93 pp. 18-27
ISSN:
0145-305X
Subject:
host-pathogen relationships; pathogens,   etc   ; Candida albicans; Schmidtea mediterranea; animal models; fungi; humans; innate immunity; signal transduction; stem cells; tissues;     Show all 11 Subjects
Abstract:
... Candida albicans is one of the most common fungal pathogens of humans. Currently, there are limitations in the evaluation of C. albicans infection in existing animal models, especially in terms of understanding the influence of specific infectious stages of the fungal pathogen on the host. We show that C. albicans infects, grows and invades tissues in the planarian flatworm Schmidtea mediterranea, ...
DOI:
10.1016/j.dci.2018.12.005