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1. Infection-based chemical screens uncover host–pathogen interactions

Author:
Detweiler, Corrella S
Source:
Current opinion in microbiology 2020 v.54 pp. 43-50
ISSN:
1369-5274
Subject:
host-pathogen relationships; pathogen survival; pathogens,   etc   ; Gram-negative bacteria; Salmonella enterica; innate immunity; macrophages; screening;     Show all 8 Subjects
Abstract:
... Bacterial pathogens must resist host innate immunity to cause disease. While Gram-negative bacteria have a protective outer membrane, this membrane is subject to host-induced damage that makes these pathogens vulnerable. We developed a high content screening platform that identifies compounds that cause the killing of the bacterial pathogen Salmonella enterica in macrophages. This platform enables ...
DOI:
10.1016/j.mib.2019.12.003

2. Phage Cocktail Therapy: Multiple Ways to Suppress Pathogenicity

Author:
Liu, Na; Lewis, Connor; Zheng, Wenming; Fu, Zheng Qing
Source:
Trends in plant science 2020 v.25 no.4 pp. 315-317
ISSN:
1360-1385
Subject:
pathogens,   etc   ; bacterial wilt; pathogenicity; phages; therapeutics; tomatoes;     Show all 6 Subjects
Abstract:
... Phage cocktails have emerged as precision tools for controlling plant bacterial diseases. Wang et al. now report that phage cocktails decreased the occurrence of tomato bacterial wilt disease efficiently by infecting and destroying bacterial pathogens, selecting phage-resistant but slow-growing pathogen strains, and fostering bacterial species that are antagonistic to the pathogens. ...
DOI:
10.1016/j.tplants.2020.01.013

3. The vacuole guard hypothesis: how intravacuolar pathogens fight to maintain the integrity of their beloved home

Author:
Anand, Ila; Choi, Wonyoung; Isberg, Ralph R
Source:
Current opinion in microbiology 2020 v.54 pp. 51-58
ISSN:
1369-5274
Subject:
pathogens,   etc   ; Shigella flexneri; bacteria; niches; proteins; vacuoles;     Show all 6 Subjects
Abstract:
... Intravacuolar bacterial pathogens establish intracellular niches by constructing membrane-encompassed compartments. The vacuoles surrounding the bacteria are remarkably stable, facilitating microbial replication and preventing exposure to host cytoplasmically localized innate immune sensing mechanisms. To maintain integrity of the membrane compartment, the pathogen is armed with defensive weapons ...
DOI:
10.1016/j.mib.2020.01.008

4. An Ecosystems Perspective on Virus Evolution and Emergence

Author:
French, Rebecca K.; Holmes, Edward C.
Source:
Trends in microbiology 2020 v.28 no.3 pp. 165-175
ISSN:
0966-842X
Subject:
pathogens,   etc   ; ecosystems; environmental health; evolution; metagenomics;     Show all 5 Subjects
Abstract:
... Understanding the emergence of pathogenic viruses has dominated studies of virus evolution. However, new metagenomic studies imply that relatively few of an immense number of viruses may lead to overt disease. This suggests a change in emphasis, from viruses as habitual pathogens to integral components of ecosystems. Here we show how viruses alter interactions between host individuals, populations ...
DOI:
10.1016/j.tim.2019.10.010

5. What Is Wrong with Enterococcal Probiotics?

Author:
Suvorov, Alexander
Source:
Probiotics and antimicrobial proteins 2020 v.12 no.1 pp. 1-4
ISSN:
1867-1306
Subject:
pathogens,   etc   ; Enterococcus; cheeses; humans; probiotics; salami; uncertainty;     Show all 7 Subjects
Abstract:
... Enterococci, being the common part of indigenous human microbiota and present in numerous fermented food products and probiotics, are often positioned as health-threatening bacterial pathogens. This makes medical community, especially part of it which is not involved in microbiology research, in an uncertainty regarding the legitimacy of using enterococcal probiotics in medical practice or even co ...
DOI:
10.1007/s12602-020-09633-y

6. Eco‐holobiont: A new concept to identify drivers of host‐associated microorganisms

Author:
Singh, Brajesh K.; Liu, Hongwei; Trivedi, Pankaj
Source:
Environmental microbiology 2020 v.22 no.2 pp. 564-567
ISSN:
1462-2912
Subject:
host-pathogen relationships,   etc   ; biocenosis; microbiome; microorganisms;     Show all 4 Subjects
Abstract:
... Host microbiomes play a critical role in host fitness and health. Whilst the current 'holobiont' concept framework has greatly expanded eco‐evolutionary and functional understanding of host‐microbiome interactions, the important role of biotic interactions and microbial loop (compositional linkage between soil, plant and animal) in shaping host‐microbiome are poorly understood. We proposed an 'eco ...
DOI:
10.1111/1462-2920.14900

7. Overview on the review articles published during the past 30 years relating to the potential climate change effects on plant pathogens and crop disease risks

Author:
Juroszek, P.; Racca, P.; Link, S.; Farhumand, J.; Kleinhenz, B.
Source:
Plant pathology 2020 v.69 no.2 pp. 179-193
ISSN:
0032-0862
Subject:
plant pathogens,   etc   ; climate change; crops; risk;     Show all 4 Subjects
Abstract:
... From 1988 to July 2019 more than 100 review articles were published, including opinion papers and book chapters, that focused on potential climate change effects on plant pathogens and the future crop disease risks. Therefore, an overview of them is presented herein, particularly helpful for beginners and non‐experts in climate change biology research. Specifically, this overview contributes to a ...
DOI:
10.1111/ppa.13119

8. First report on aberrant Ascaris suum infection in a dog, China

Author:
Xie, Yue; Liu, Yunjian; Gu, Xiaobin; Zhou, Xuan; Peng, Xuerong; He, Ran; Guo, Hongrui; Zuo, Zhicai; Yang, Guangyou
Source:
Parasites & vectors 2020 v.13 no.1 pp. 86
ISSN:
1756-3305
Subject:
pathogens,   etc   ; Ascaris suum; animal diseases; dogs; humans; swine; China;     Show all 7 Subjects
Abstract:
... An aberrant Ascaris suum infection in a domestic dog in China in 2019 is described for the first time. This pathogen is a common roundworm of pigs with few reported cases in domestic animals. Our findings suggest a wider infection range with a possible transmission of A. suum to domestic animals that interact with humans. ...
DOI:
10.1186/s13071-020-3963-0
PubMed:
32070412
PubMed Central:
PMC7029576

9. Symbiotic bacteria of plant-associated fungi: friends or foes?

Author:
Bastías, Daniel A; Johnson, Linda J; Card, Stuart D
Source:
Current opinion in plant biology 2020 v.56 pp. 1-8
ISSN:
1369-5266
Subject:
pathogens,   etc   ; bacteria; environmental factors; fungi; genotype; hyphae; microsymbionts; mycelium;     Show all 8 Subjects
Abstract:
... Many bacteria form symbiotic associations with plant-associated fungi. The effects of these symbionts on host fitness usually depend on symbiont or host genotypes and environmental conditions. However, bacterial endosymbionts, that is those living within fungal cells, may positively regulate host performance as their survival is often heavily dependent on host fitness. Contrary to this, bacteria t ...
DOI:
10.1016/j.pbi.2019.10.010

10. Improving state-level emergency well disinfection strategies in the United States

Author:
Pieper, Kelsey J.; Rhoads, William J.; Saucier, Leslie; Katner, Adrienne; Barrett, Jason R.; Edwards, Marc
Source:
The Science of the total environment 2020 v.720 pp. 137451
ISSN:
0048-9697
Subject:
pathogens,   etc   ; Cryptosporidium; chlorine; disinfection; pH; well water; wells; United States;     Show all 8 Subjects
Abstract:
... After flooding events, well users are encouraged to disinfect their private wells. However, well disinfection strategies are not consistently applied or proven effective. This study examines the science-based evidence that disinfection procedures reduce microbial loading in well water; reviews inclusion of disinfection principles in state-level emergency protocols; and explores research gaps poten ...
DOI:
10.1016/j.scitotenv.2020.137451

11. Multi-metal nutrient restriction and crosstalk in metallostasis systems in microbial pathogens

Author:
Jordan, Matthew R; Wang, Jiefei; Capdevila, Daiana A; Giedroc, David P
Source:
Current opinion in microbiology 2020 v.55 pp. 17-25
ISSN:
1369-5274
Subject:
pathogens,   etc   ; bacteria; catalytic activity; enzymes; immunity; manganese; proteins; zinc;     Show all 8 Subjects
Abstract:
... Transition metals from manganese to zinc function as catalytic and structural cofactors for an amazing diversity of proteins and enzymes, and thus are essential for all forms of life. During infection, inflammatory host proteins limit the accessibility of multiple transition metals to invading pathogens in a process termed nutritional immunity. In order to respond to host-mediated metal starvation ...
DOI:
10.1016/j.mib.2020.01.010

12. An Omnivore’s Dilemma: Toxoplasma gondii’s Flexible Metabolic Networks

Author:
Kim, Kami
Source:
Trends in parasitology 2020 v.36 no.5 pp. 408-410
ISSN:
1471-4922
Subject:
pathogens,   etc   ; Toxoplasma gondii; biochemical pathways; metabolomics; models; nutrients; omnivores; transcriptomics;     Show all 8 Subjects
Abstract:
... Host cells provide protection from the environment for intracellular pathogens, but acquisition of nutrients and sensing of changes in the host cell bring new challenges. Krishnan et al. have recently developed a comprehensive genome-scale metabolic model (GEM) of the Toxoplasma gondii metabolic network that incorporates genetic, transcriptomic, and metabolomic data. ...
DOI:
10.1016/j.pt.2020.02.002

13. Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations

Author:
Havenar-Daughton, Colin; Newton, Isabel G.; Zare, Somaye Y.; Reiss, Samantha M.; Schwan, Brittany; Suh, Min Ji; Hasteh, Farnaz; Levi, Gina; Crotty, Shane
Source:
Journal of immunological methods 2020 v.479 pp. 112746
ISSN:
0022-1759
Subject:
pathogens,   etc   ; B-lymphocytes; autoimmune diseases; humans; hypersensitivity; lymph nodes; vaccination;     Show all 7 Subjects
Abstract:
... Germinal centers (GC) are critically important for maturation of the antibody response and generation of memory B cells, processes that form the basis for long-term protection from pathogens. GCs only occur in lymphoid tissue, such as lymph nodes, and are not present in blood. Therefore, GC B cells and GC T follicular helper (TFH) cells are not well-studied in humans under normal healthy condition ...
DOI:
10.1016/j.jim.2020.112746
PubMed:
31958451
PubMed Central:
PMC7200018

14. Patterns of partnership: surveillance and mimicry in host-microbiota mutualisms

Author:
Wiles, Travis J; Guillemin, Karen
Source:
Current opinion in microbiology 2020 v.54 pp. 87-94
ISSN:
1369-5274
Subject:
pathogens,   etc   ; metabolism; microbial activity; microbial communities; microorganisms; monitoring; mutualism;     Show all 7 Subjects
Abstract:
... The repertoire of microbial cues monitored by animal and plant tissues encompasses not just molecules but also microbial activities. These include typical pathogen strategies of injuring membranes, degrading cellular material, and scavenging resources. These activities, however, are not exclusive to pathogens. Instead, they characterize the competitive strategies of microbes living in multispecies ...
DOI:
10.1016/j.mib.2020.01.012

15. The unconventional role of HLA-E: The road less traveled

Author:
Grant, Emma J.; Nguyen, Andrea T.; Lobos, Christian A.; Szeto, Christopher; Chatzileontiadou, Demetra S.M.; Gras, Stephanie
Source:
Molecular immunology 2020 v.120 pp. 101-112
ISSN:
0161-5890
Subject:
pathogens,   etc   ; T-lymphocytes; adaptive immunity; antigens; humans; monitoring; peptides;     Show all 7 Subjects
Abstract:
... Histocompatibility Leukocyte Antigens, or HLAs, are one of the most polymorphic molecules in humans. This high degree of polymorphism endows HLA molecules with the ability to present a vast array of peptides, an essential trait for responding to ever-evolving pathogens. Unlike classical HLA molecules (HLA-Ia), some non-classical HLA-Ib molecules, including HLA-E, are almost monomorphic. Several st ...
DOI:
10.1016/j.molimm.2020.02.011

16. Correction to: Dissecting molecular events and gene expression signatures involved in Colletotrichum lindemuthianum-Phaseolusvulgaris pathosystem in compatible and incompatible interactions

Author:
Shams, E.; Javan-Nikkhah, M.; Mirzadi Gohari, A.
Source:
European journal of plant pathology 2020 v.156 no.3 pp. 993-994
ISSN:
0929-1873
Subject:
host-pathogen relationships,   etc   ; Colletotrichum; Phaseolus vulgaris; gene expression;     Show all 4 Subjects
Abstract:
... Due to proofing error Fig.2 was published with inferior quality and has now been updated with a better quality version. ...
DOI:
10.1007/s10658-020-01960-8

17. James Robert Alfano, A Giant in Phytopathogenic Bacteria Effector Biology

Author:
Collmer, Alan
Source:
Molecular plant-microbe interactions 2020 v.33 no.3 pp. 377-381
ISSN:
0894-0282
Subject:
host-pathogen relationships,   etc   ; Pseudomonas syringae; pathogenesis; plant pathogenic bacteria;     Show all 4 Subjects
Abstract:
... The worldwide molecular plant-microbe interactions research community was significantly diminished in November 2019 by the death of James “Jim” Robert Alfano at age 56. Jim was a giant in our field, who gained key insights into plant pathogenesis using the model bacterial pathogen Pseudomonas syringae. As a mentor, collaborator, and, above all, a friend, I know Jim’s many dimensions and accomplish ...
DOI:
10.1094/MPMI-12-19-0354-CR

18. Pathogen-induced Defense Strategies in Plants

Author:
Imran, Qari Muhammad; Yun, Byung-Wook
Source:
Journal of crop science and biotechnology 2020 v.23 no.2 pp. 97-105
ISSN:
1975-9479
Subject:
pathogens,   etc   ; biotic stress; ecosystems; environmental factors; plant response; postharvest losses;     Show all 6 Subjects
Abstract:
... Plants are the ultimate producers of this ecosystem and effect human life directly and/or indirectly. However, being sessile organisms, plants are susceptible to several adverse environmental conditions and pathogen ingress resulting in huge losses to yield and productivity. Therefore, plans are continuously evolving complex regulatory networks to respond to these environmental changes. Due to its ...
DOI:
10.1007/s12892-019-0352-0

19. Antimycobacterial Rufomycin Analogues from Streptomyces atratus Strain MJM3502

Author:
Zhou, Bin; Shetye, Gauri; Yu, Yang; Santarsiero, Bernard D.; Klein, Larry L.; Abad-Zapatero, Cele; Wolf, Nina M.; Cheng, Jinhua; Jin, Yingyu; Lee, Hanki; Suh, Joo-Won; Lee, Hyun; Bisson, Jonathan; McAlpine, James B.; Chen, Shao-Nong; Cho, Sang-Hyun; Franzblau, Scott G.; Pauli, Guido F.
Source:
Journal of natural products 2020 v.83 no.3 pp. 657-667
ISSN:
1520-6025
Subject:
pathogens,   etc   ; Mycobacterium tuberculosis; Streptomyces atratus; X-ray diffraction; drugs; peptides;     Show all 6 Subjects
Abstract:
... This study represents a systematic chemical and biological study of the rufomycin (RUF) class of cyclic heptapeptides, which our anti-TB drug discovery efforts have identified as potentially promising anti-TB agents that newly target the caseinolytic protein C1, ClpC1. Eight new RUF analogues, rufomycins NBZ1–NBZ8 (1–8), as well as five known peptides (9–13) were isolated and characterized from th ...
DOI:
10.1021/acs.jnatprod.9b01095

20. Growth detection of Cutibacterium acnes from orthopaedic implant-associated infections in anaerobic bottles from BACTEC and BacT/ALERT blood culture systems and comparison with conventional culture media

Author:
Jeverica, Samo; El Sayed, Faten; Čamernik, Petra; Kocjančič, Boštjan; Sluga, Boštjan; Rottman, Martin; Papst, Lea
Source:
Anaerobe 2020 v.61 pp. 102133
ISSN:
1075-9964
Subject:
pathogens,   etc   ; agar; blood; bottles; chocolate; culture media; orthopedics; France; Slovenia;     Show all 9 Subjects
Abstract:
... Cutibacterium acnes is a major etiologic agent of orthopaedic implant-associated infections (IAIs) and requires up to 14 days of incubation in an anaerobic atmosphere for growth detection. As blood culture (BC) systems are increasingly being used to monitor the growth of IAI specimens, we compared different BC media for growth detection of C. acnes. Non-duplicate C. acnes isolates (n = 99) obtaine ...
DOI:
10.1016/j.anaerobe.2019.102133