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1. Experimental and theoretical tools to elucidate the binding mechanisms of solid-binding peptides

Author:
Bansal, Rachit; Care, Andrew; Lord, Megan S.; Walsh, Tiffany R.; Sunna, Anwar
Source:
New biotechnology 2019 v.52 pp. 9-18
ISSN:
1871-6784
Subject:
peptides,   etc   ; binding capacity; nanobiotechnology;     Show all 3 Subjects
Abstract:
... The interactions between biomolecules and solid surfaces play an important role in designing new materials and applications which mimic nature. Recently, solid-binding peptides (SBPs) have emerged as potential molecular building blocks in nanobiotechnology. SBPs exhibit high selectivity and binding affinity towards a wide range of inorganic and organic materials. Although these peptides have been ...
DOI:
10.1016/j.nbt.2019.04.001

2. The de novo design of α-helical peptides for supramolecular self-assembly

Author:
Beesley, Joseph L; Woolfson, Derek N
Source:
Current opinion in biotechnology 2019 v.58 pp. 175-182
ISSN:
0958-1669
Subject:
peptides,   etc   ; hydrogels; nanotubes;     Show all 3 Subjects
Abstract:
... One approach to designing de novo proteinaceous assemblies and materials is to develop simple, standardised building blocks and then to combine these symmetrically to construct more-complex higher-order structures. This has been done extensively using β-structured peptides to produce peptide fibres and hydrogels. Here, we focus on building with de novo α-helical peptides. Because of their self-con ...
DOI:
10.1016/j.copbio.2019.03.017

3. Bias in False Discovery Rate Estimation in Mass-Spectrometry-Based Peptide Identification

Author:
Danilova, Yulia; Voronkova, Anastasia; Sulimov, Pavel; Kertész-Farkas, Attila
Source:
Journal of proteome research 2019 v.18 no.5 pp. 2354-2358
ISSN:
1535-3907
Subject:
peptides,   etc   ; mass spectrometry; proteome;     Show all 3 Subjects
Abstract:
... Accurate target-decoy-based false discovery rate (FDR) control of peptide identification from tandem mass-spectrometry data relies on an important but often neglected assumption that incorrect spectrum annotations are equally likely to receive either target or decoy peptides. Here we argue that this assumption is often violated in practice, even by popular methods. Preference can be given to targe ...
DOI:
10.1021/acs.jproteome.8b00991

4. Correction to: Gene delivery into the plant mitochondria via organelle-specific peptides

Author:
MacMillan, Trevor; Ziemienowicz, Alicja; Jiang, Fengying; Eudes, François; Kovalchuk, Igor
Source:
Plant biotechnology reports 2019 v.13 no.1 pp. 25
ISSN:
1863-5466
Subject:
peptides,   etc   ; gene transfer; mitochondria;     Show all 3 Subjects
Abstract:
... In the Original publication of the article the copyright was incorrectly published with “© The Author 2018”. The correct copyright is “© Crown 2018”. ...
DOI:
10.1007/s11816-018-0510-y

5. Molecular mechanism of protein import specificity to chloroplasts and mitochondria in plant cells

Author:
Lee, Dong Wook; Lee, Sumin; Lee, Junho; Woo, Seungjin; Razzak, Md.Abdur; Vitale, Alessandro; Hwang, Inhwan
Source:
Molecular plant 2019
ISSN:
1674-2052
Subject:
peptides; signal peptide,   etc   ; arginine; chloroplasts; hydrophobicity; imports; mitochondria; protein transport;     Show all 8 Subjects
Abstract:
... Plants possess both types of endosymbiotic organelles, chloroplasts and mitochondria. Transit peptides and presequences function as signal sequences for specific import into chloroplasts and mitochondria, respectively. However, how these highly similar signal sequences confer this import specificity remains elusive. Here, we show that mitochondrial- or chloroplast-specific import involves two dist ...
DOI:
10.1016/j.molp.2019.03.003

6. Molecular Basis of Phage Communication

Author:
Rajaure, Manoj; Adhya, Sankar
Source:
Molecular cell 2019 v.74 no.1 pp. 1-2
ISSN:
1097-2765
Subject:
peptides,   etc   ; Bacillus (bacteria); bacteriophages; proteins;     Show all 4 Subjects
Abstract:
... Recently members of Bacillus phages were found to utilize a small peptide (6 aa long) to communicate with their descendants, aiding in a complex decision-making process. Proteins involved in this remarkable viral communication phenomenon were further investigated at the structural level for better understanding in this issue of Molecular Cell (Gallego del Sol et al., 2019). ...
DOI:
10.1016/j.molcel.2019.03.015

7. Human Antibody Bispecifics through Phage Display Selection

Author:
Luthra, Ansha; Langley, David B.; Schofield, Peter; Jackson, Jennifer; Abdelatti, Mahmoud; Rouet, Romain; Nevoltris, Damien; Mazigi, Ohan; Crossett, Ben; Christie, Mary; Christ, Daniel
Source:
Biochemistry 2019 v.58 no.13 pp. 1701-1704
ISSN:
1520-4995
Subject:
peptide libraries,   etc   ; antibodies; humans; mutation;     Show all 4 Subjects
Abstract:
... We developed a repertoire approach to generate human antibody bispecifics. Using phage display selection of antibody heavy chains in the presence of a competitor light chain and providing a cognate light chain with an affinity handle, we identified mutations that prevent heavy/light chain mispairing. The strategy allows for the selection of human antibody chains that autonomously assemble into bis ...
DOI:
10.1021/acs.biochem.9b00037

8. Asymmetric synthesis of (2S,3S)-3-Me-glutamine and (R)-allo-threonine derivatives proper for solid-phase peptide coupling

Author:
Tokairin, Yoshinori; Soloshonok, Vadim A.; Moriwaki, Hiroki; Konno, Hiroyuki
Source:
Amino acids 2019 v.51 no.3 pp. 419-432
ISSN:
0939-4451
Subject:
peptides,   etc   ; chemical reactions; cytotoxicity; nickel;     Show all 4 Subjects
Abstract:
... Practical new routes for preparation of (2S,3S)-3-Me-glutamine and (R)-allo-threonine derivatives, the key structural components of cytotoxic marine peptides callipeltin O and Q, suitable for the Fmoc-SPPS, were developed. (2S,3S)-Fmoc-3-Me-Gln(Xan)-OH was synthesized via Michael addition reactions of Ni (II) complex of chiral Gly-Schiff base; while Fmoc-(R)-allo-Thr-OH was prepared using chiral N ...
DOI:
10.1007/s00726-018-2677-5

9. Sulfo-click chemistry with ¹⁸F-labeled thio acids

Author:
Urkow, Jenna; Bergman, Cody; Wuest, Frank
Source:
Chemical communications 2019 v.55 no.9 pp. 1310-1313
ISSN:
1364-548X
Subject:
peptides,   etc   ; acids; chemical reactions; radiolabeling;     Show all 4 Subjects
Abstract:
... The first application of sulfo-click chemistry with ¹⁸F-labeled thio acids is described. The simple one-pot/three-component reaction proceeded rapidly within 30 min using mild reaction conditions to give various ¹⁸F-labeled small molecule N-acylsulfonamides in radiochemical conversions of 38–99%, and radiolabeled peptides in 20–25% isolated and decay-corrected radiochemical yields. ...
DOI:
10.1039/c8cc08717b

10. Yeast arming systems: pros and cons of different protein anchors and other elements required for display

Author:
Andreu, Cecilia; del Olmo, Marcellí
Source:
Applied microbiology and biotechnology 2018 v.102 no.6 pp. 2543-2561
ISSN:
0175-7598
Subject:
peptides; signal peptide,   etc   ; proteins; yeasts;     Show all 4 Subjects
Abstract:
... Yeast display is a powerful strategy that consists in exposing peptides or proteins of interest on the cell surface of this microorganism. Ever since initial experiments with this methodology were carried out, its scope has extended and many applications have been successfully developed in different science and technology fields. Several yeast display systems have been designed, which all involve ...
DOI:
10.1007/s00253-018-8827-6

11. Protein oxidation during temperature-induced amyloid aggregation of beta-lactoglobulin

Author:
Keppler, Julia K.; Heyn, Timon R.; Meissner, Philipp M.; Schrader, Katrin; Schwarz, Karin
Source:
Food chemistry 2019 v.289 pp. 223-231
ISSN:
0308-8146
Subject:
peptides,   etc   ; amyloid; beta-lactoglobulin; oxidation; pH; tyrosine;     Show all 6 Subjects
Abstract:
... Although the connection between protein oxidation, amyloid aggregation and diseases such as Alzheimer’s is well known there is no information on such effects during preparation of beta-lactoglobulin fibrils. Different morphologies of amyloid aggregates of beta-lactoglobulin were prepared by incubation at pH 2 or pH 3.5 for up to 72 h. After 5 h, amyloid aggregates at pH 2 formed typical fibrils, w ...
DOI:
10.1016/j.foodchem.2019.02.114

12. Amino acid conformations control the morphological and chiral features of the self-assembled peptide nanostructures: Young investigators perspective

Author:
Zhou, Peng; Wang, Jiqian; Wang, Meng; Hou, Jian; Lu, Jian R.; Xu, Hai
Source:
Journal of colloid and interface science 2019 v.548 pp. 244-254
ISSN:
0021-9797
Subject:
peptides,   etc   ; amino acids; geometry; nanomaterials; optical isomerism;     Show all 5 Subjects
Abstract:
... A variety of nanostructures with different chiral features can be self-assembled from short peptides with highly similar sequences. We hypothesize that these supramolecular nanostructures are ruled by the constituent amino acid residues which adopt their conformations under the influence of intra-/inter-molecular interactions during peptide self-assembly.Through reviewing recent advances in the se ...
DOI:
10.1016/j.jcis.2019.04.019

13. Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Author:
Braga Emidio, Nayara; Hoffmann, Werner; Brierley, Stuart M.; Muttenthaler, Markus
Source:
Trends in biochemical sciences 2019 v.44 no.5 pp. 387-390
ISSN:
0968-0004
Subject:
peptides,   etc   ; digestive system diseases; lectins; therapeutics;     Show all 4 Subjects
Abstract:
... The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo. ...
DOI:
10.1016/j.tibs.2019.01.004

14. Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation

Author:
Amoura, Mehdi; Illien, Françoise; Joliot, Alain; Guitot, Karine; Offer, John; Sagan, Sandrine; Burlina, Fabienne
Source:
Chemical communications 2019 v.55 no.31 pp. 4566-4569
ISSN:
1364-548X
Subject:
peptides,   etc   ; chemical compounds; chemical reactions; endocytosis; lipids;     Show all 5 Subjects
Abstract:
... A series of cyclic lipidated oligo-Arg cell penetrating peptides were synthesised with varied macrocycle size and lipid chain anchoring site. The study of their cellular uptake revealed different structural requirements to promote efficient glycosaminoglycan-dependent endocytosis and direct translocation. ...
DOI:
10.1039/c9cc01265f

15. Correction to: Production of a Recombinant Dermaseptin Peptide in Nicotiana tabacum Hairy Roots with Enhanced Antimicrobial Activity

Author:
Shams, Marzieh Varasteh; Nazarian-Firouzabadi, Farhad; Ismaili, Ahmad; Shirzadian-Khorramabad, Reza
Source:
Molecular biotechnology 2019 v.61 no.4 pp. 253
ISSN:
1073-6085
Subject:
peptides,   etc   ; Nicotiana tabacum; antimicrobial properties; roots;     Show all 4 Subjects
Abstract:
... The original version of this article unfortunately contained a mistake in the unit “μg/l”. The unit “μg/l” should be corrected to “μg/ml” throughout the paper. ...
DOI:
10.1007/s12033-019-00157-7

16. Functionality of an absolutely conserved glycine residue in the chimeric relaxin family peptide R3/I5

Author:
Wang, Jia-Hui; Shao, Xiao-Xia; Hu, Meng-Jun; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun
Source:
Amino acids 2019 v.51 no.4 pp. 619-626
ISSN:
0939-4451
Subject:
peptides,   etc   ; agonists; cysteine; insulin; mutagenesis; receptors; relaxin;     Show all 7 Subjects
Abstract:
... The insulin superfamily is a group of homologous proteins that are further divided into the insulin family and relaxin family according to their distinct receptors. All insulin superfamily members contain three absolutely conserved disulfide linkages and a nonchiral Gly residue immediately following the first B-chain cysteine. The functionality of this conserved Gly residue in the insulin family h ...
DOI:
10.1007/s00726-018-02694-y

17. Occurrence, function, and biosynthesis of mycofactocin

Author:
Ayikpoe, Richard; Govindarajan, Vishnu; Latham, John A.
Source:
Applied microbiology and biotechnology 2019 v.103 no.7 pp. 2903-2912
ISSN:
0175-7598
Subject:
peptides,   etc   ; Actinobacteria; biochemical pathways; biosynthesis; enzymes; quinones;     Show all 6 Subjects
Abstract:
... Mycofactocin is a member of the rapidly growing class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. Although the mycofactocin biosynthetic pathway is widely distributed among Mycobacterial species, the structure, function, and biosynthesis of the pathway product remain unknown. This mini-review will discuss the current state of knowledge regarding th ...
DOI:
10.1007/s00253-019-09684-4

18. Structural insights into the 3′-end mRNA maturation machinery: Snapshot on polyadenylation signal recognition

Author:
Thore, Stéphane; Fribourg, Sébastien
Source:
Biochimie 2019
ISSN:
0300-9084
Subject:
signal peptide,   etc   ; humans; messenger RNA; yeasts;     Show all 4 Subjects
Abstract:
... Pre-mRNA 3′-end maturation is achieved by a mechanism requiring four different protein complexes assembled from approximately twenty factors. A global understanding of this essential process is still missing due to the inability to structurally characterize the entire complexes, even though structures of the isolated factors have been obtained. In this review, we summarize recent findings regardin ...
DOI:
10.1016/j.biochi.2019.03.016

19. Pseudo-Wang Handle for the Preparation of Fully Protected Peptides. Synthesis of Liraglutide by Fragment Condensation

Author:
Carbajo, Daniel; Fransen, Peter; El-Faham, Ayman; Royo, Miriam; Albericio, Fernando
Source:
Organic letters 2019 v.21 no.7 pp. 2459-2463
ISSN:
1523-7052
Subject:
peptides,   etc   ; chemical structure; organic compounds; polymerization;     Show all 4 Subjects
Abstract:
... A handle for the protection of the C-terminus of peptides after cleaving with low concentration of trifluoroacetic acid (2–4%) is reported. The handle prevents polymerization reactions in the convergent condensation of peptidic fragments. Moreover, it is traceless, being removed during the final deprotection step of the peptide synthesis. This cheap and convenient handle is easily attached to the ...
DOI:
10.1021/acs.orglett.9b00813

20. Hitting Undruggable Targets: Viewing Stabilized Peptide Development through the Lens of Quantitative Systems Pharmacology

Author:
Atangcho, Lydia; Navaratna, Tejas; Thurber, Greg M.
Source:
Trends in biochemical sciences 2019 v.44 no.3 pp. 241-257
ISSN:
0968-0004
Subject:
peptides,   etc   ; drugs; genome; pharmacokinetics; screening; therapeutics; toxicity;     Show all 7 Subjects
Abstract:
... Stabilized peptide therapeutics have the potential to hit currently undruggable targets, dramatically expanding the druggable genome. However, major obstacles to their development include poor intracellular delivery, rapid degradation, low target affinity, and membrane toxicity. With the emergence of multiple stabilization techniques and screening technologies, the high efficacy of various bioacti ...
DOI:
10.1016/j.tibs.2018.11.008