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1. Identification of novel umami peptides from Boletus edulis and its mechanism via sensory analysis and molecular simulation approaches

Author:
Shiqing Song; Jinda Zhuang; Changzhong Ma; Tao Feng; Lingyun Yao; Chi-Tang Ho; Min Sun
Source:
Food chemistry 2023 v.398 pp. 133835
ISSN:
0308-8146
Subject:
peptides,   etc   ; Boletus edulis; food chemistry; hydrogen; hydrophobicity; molecular dynamics; monosodium glutamate; sensory evaluation; structure-activity relationships; umami;     Show all 10 Subjects
Abstract:
... The study aimed to identify umami peptides from Boletus edulis and explore their umami mechanism. 421, 713 and 616 peptides identified by LC-MS/MS from control sample (CS), enzymatically extracted sample (EES) and high-pressure cooking sample (HPCS), respectively. According to molecular docking study, three potential umami peptides (DGF, KCGQ and HHYE) were chemically synthesized for sensory evalu ...
DOI:
10.1016/j.foodchem.2022.133835

2. Dynamic changes of urotensin II and its receptor during ovarian development of olive flounder Paralichthys olivaceus

Author:
Xiaoxue Li; Hong Zhou; Chunmei Ge; Kunyu Li; Aqin Chen; Weiqun Lu
Source:
Comparative biochemistry and physiology 2023 v.263 pp. 110782
ISSN:
1096-4959
Subject:
peptides,   etc   ; Paralichthys olivaceus; cytoplasm; human chorionic gonadotropin; hybridization; immunohistochemistry; lipid metabolism; neurosecretory system; oocytes; osmoregulation; ovarian development; transcription (genetics);     Show all 12 Subjects
Abstract:
... Urotensin II (UII) is a kind of fish somatostatins cyclic peptide, which was originally extracted from the caudal neurosecretory system (CNSS). The system of UII and UII receptor (UIIR) has been reported to have multiple physiological regulatory functions, such as cardiovascular control, osmoregulation, and lipid metabolism. However, the effect of UII and UIIR on the ovarian development has not be ...
DOI:
10.1016/j.cbpb.2022.110782

3. Process optimization, texture and microstructure of novel kelp tofu

Author:
Xianjiang Ye; Li Chen; Zhichen Su; Xiaojuan Lin; Jicheng Chen
Source:
Food science and human wellness 2023 v.12 no.1 pp. 111-118
ISSN:
2213-4530
Subject:
peptides,   etc   ; Saccharina japonica; enzymes; food science; gypsum; humans; hydrolysates; macroalgae; medicine; microstructure; sensory evaluation; temperature; texture; tofu; traditional foods;     Show all 15 Subjects
Abstract:
... Laminaria japonica Aresch as an edible and medicine dual-purpose marine algae, has been gradually accepted by people. Tofu was Chinese traditional food, combining kelp function ingredients with tofu has practical value. The extraction-optimization methodology and the sequences of kelp antihypertensive peptide (KAP) were investigated. The sensory, whiteness, water retention ability (WRA) and micros ...
DOI:
10.1016/j.fshw.2022.07.029

4. RPS6 transcriptional modulation in neural tissues of Nauphoeta cinerea during streptozotocin-associated sugar metabolism impairment.

Author:
Olawande C. Olagoke; Ana L.A. Segatto; Blessing A. Afolabi; Daniel Ardisson-Araujo; Michael Aschner; João B.T. Rocha
Source:
Comparative biochemistry and physiology 2023 v.263 pp. 110785
ISSN:
1096-4959
Subject:
peptides,   etc   ; Nauphoeta cinerea; biomedical research; brain; glucose; hyperglycemia; insects; metabolism; non-specific serine/threonine protein kinase; ribosomal proteins; sequence analysis; streptozotocin; transcription (genetics);     Show all 13 Subjects
Abstract:
... The use of insects to model molecular events that characterize degenerative conditions was originally met with scepticism. However, the discovery of insect insulin-like peptides in the 1970's and the demonstration of evolutionary conservation of insulin-related signalling from insects to mammals have highlighted the importance and reduced cost of insect models in biomedical research. Here, we expa ...
DOI:
10.1016/j.cbpb.2022.110785

5. Optimization of a sample preparation workflow based on UHPLC-MS/MS method for multi-allergen detection in chocolate: An outcome of the ThRAll project

Author:
Jean Henrottin; Rosa Pilolli; Anne-Catherine Huet; Christof van Poucke; Chiara Nitride; Marc De Loose; Olivier Tranquet; Colette Larré; Karine Adel-Patient; Hervé Bernard; E.N. Clare Mills; Nathalie Gillard; Linda Monaci
Source:
Food control 2023 v.143 pp. 109256
ISSN:
0956-7135
Subject:
peptides,   etc   ; allergenicity; allergens; almonds; chocolate; digestion; eggs; food industry; food matrix; food safety; hazelnuts; hens; lipids; milk; peanuts; polyphenols; processed foods; prototypes; risk assessment;     Show all 19 Subjects
Abstract:
... Developing reliable methodologies for detecting and quantifying allergens in processed food commodities is crucial to support food business operators in allergen risk assessment and properly implementing precautionary allergen labels whenever required to safeguard the health of allergic consumers. Multiple Mass Spectrometry (MS) methods have been developed so far and applied for single and multi-a ...
DOI:
10.1016/j.foodcont.2022.109256

6. Strategies to Improve the Activity and Biocompatibility: Modification of Peptide Antibiotics

Author:
Jiaqi Zhang; Jin Zhang; Yitong Wang; Xin Zhang; Ting Nie; Yanan Liu
Source:
Foodborne pathogens & disease 2022 v.19 no.6 pp. 376-385
ISSN:
1556-7125
Subject:
antimicrobial peptides; cyclic peptides,   etc   ; amino acids; biocompatibility; yeasts;     Show all 5 Subjects
Abstract:
... As host defense peptides, peptide antibiotics exist in almost all organisms. Many of their activities come from their inactivation of bacteria, yeast, fungi, and even cancer cells. However, natural peptide antibiotics are relatively poor in stability and penetration, and have high hemolytic properties, which makes them difficult to directly apply. Therefore, natural peptide antibiotics can be modi ...
DOI:
10.1089/fpd.2021.0112

7. Synthetic molecular evolution of antimicrobial peptides

Author:
Charles H Chen; Tristan Bepler; Karen Pepper; Debbie Fu; Timothy K Lu
Source:
Current opinion in biotechnology 2022 v.75 pp. 102718
ISSN:
0958-1669
Subject:
antimicrobial peptides; synthetic peptides,   etc   ; amino acids; biotechnology; computer simulation; drugs; evolution; labor;     Show all 8 Subjects
Abstract:
... As we learn more about how peptide structure and activity are related, we anticipate that antimicrobial peptides will be engineered to have strong potency and distinct functions and that synthetic peptides will have new biomedical applications, such as treatments for emerging infectious diseases. As a result of the enormous number of possible amino acid sequences and the low-throughput nature of a ...
DOI:
10.1016/j.copbio.2022.102718

8. Chemo- and Site-Selective Replacement of N-Terminal Carbamates in Peptides

Author:
Miho Ibara; Takumi Abe; Daisuke Sawada
Source:
Organic letters 2022 v.24 no.11 pp. 2131-2136
ISSN:
1523-7052
Subject:
peptides,   etc   ; carbamates; fluorine;     Show all 3 Subjects
Abstract:
... In peptide synthesis, it is important to distinguish the terminal amino group and carry out the selective transformation of only the N-terminal protecting group. We describe herein a reaction for the chemo- and site-selective replacement of carbamates with various other carbamates only at the N-terminus of peptides. We demonstrate the scope of carbamates and peptides and the introduction of fluori ...
DOI:
10.1021/acs.orglett.2c00370

9. Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage

Author:
Jessica Rodríguez; Cibrán Pérez-González; Miguel Martínez-Calvo; Jesús Mosquera; José L. Mascareñas
Source:
RSC advances 2022 v.12 no.6 pp. 3500-3504
ISSN:
2046-2069
Subject:
peptides,   etc   ; DNA; palladium;     Show all 3 Subjects
Abstract:
... Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric basic regions of bZIP transcription factors. While the dimer binds designed DNA sequences with good affinities, the peptide–DNA complex can be readily dismounted by addition of ...
DOI:
10.1039/d1ra09180h

10. Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation

Author:
Daiki Sato; Masaya Denda; Honoka Tsunematsu; Naonobu Tanaka; Isamu Konishi; Chiaki Komiya; Akira Shigenaga; Akira Otaka
Source:
Chemical communications 2022 v.58 no.17 pp. 2918-2921
ISSN:
1364-548X
Subject:
peptides,   etc   ; thioesters; threonine;     Show all 3 Subjects
Abstract:
... Intramolecular S-acylation of a thiol-installed threonine with a thioester unit, followed by S–O acyl transfer and subsequent desulphurisation, allows the synthesis of lactone peptides. A protocol has been developed enabling the cyclisation of a linear peptide, a reaction which has not been achieved by conventional methods. ...
DOI:
10.1039/d1cc07248j

11. Peptide Tethering: Pocket-Directed Fragment Screening for Peptidomimetic Inhibitor Discovery

Author:
Ashley E. Modell; Frank Marrone; Nihar R. Panigrahi; Yingkai Zhang; Paramjit S. Arora
Source:
Journal of the American Chemical Society 2022 v.144 no.3 pp. 1198-1204
ISSN:
1520-5126
Subject:
peptides,   etc   ; ligands; topography;     Show all 3 Subjects
Abstract:
... Constrained peptides have proven to be a rich source of ligands for protein surfaces, but are often limited in their binding potency. Deployment of nonnatural side chains that access unoccupied crevices on the receptor surface offers a potential avenue to enhance binding affinity. We recently described a computational approach to create topographic maps of protein surfaces to guide the design of n ...
DOI:
10.1021/jacs.1c09666

12. Solid-Phase Photochemical Peptide Homologation Cyclization

Author:
Michael B. Elbaum; Mahmoud A. Elkhalifa; Gary A. Molander; David M. Chenoweth
Source:
Organic letters 2022 v.24 no.28 pp. 5176-5180
ISSN:
1523-7052
Subject:
peptides,   etc   ; photochemistry; therapeutics;     Show all 3 Subjects
Abstract:
... Forging new C(sp³)–C(sp³) bonds to central positions within a peptide backbone is critical for the development of new therapeutics and chemical probes. Currently, there are no methods for decarboxylating Asp and Glu side chains solid-phase photochemically or using such radicals to form peptide macrocycles. Herein, electron-donor-acceptor complexes between Hantzsch ester and on-resin peptide N-hydr ...
DOI:
10.1021/acs.orglett.2c02012

13. A β-hairpin peptide with pH-controlled affinity for tumor cells

Author:
Shin-nosuke Nishimura; Kei Nishida; Masaru Tanaka
Source:
Chemical communications 2022 v.58 no.4 pp. 505-508
ISSN:
1364-548X
Subject:
peptides,   etc   ; neoplasms; pH;     Show all 3 Subjects
Abstract:
... Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSᴰPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions. ...
DOI:
10.1039/d1cc06218b

14. Does the inclusion of electronic polarisability lead to a better modelling of peptide aggregation?

Author:
Batuhan Kav; Birgit Strodel
Source:
RSC advances 2022 v.12 no.32 pp. 20829-20837
ISSN:
2046-2069
Subject:
peptides,   etc   ; amyloid; models;     Show all 3 Subjects
Abstract:
... Simulating the process of amyloid aggregation with atomic detail is a challenging task for various reasons. One of them is that it is difficult to parametrise a force field such that all protein states ranging from the folded through the unfolded to the aggregated state are represented with the same level of accuracy. Here, we test whether the consideration of electronic polarisability improves th ...
DOI:
10.1039/d2ra01478e

15. Hydrophobic immiscibility controls self-sorting or co-assembly of peptide amphiphiles

Author:
Rie Wakabayashi; Rino Imatani; Mutsuhiro Katsuya; Yuji Higuchi; Hiroshi Noguchi; Noriho Kamiya; Masahiro Goto
Source:
Chemical communications 2022 v.58 no.4 pp. 585-588
ISSN:
1364-548X
Subject:
peptides,   etc   ; hydrophobicity; surfactants;     Show all 3 Subjects
Abstract:
... Pairs of peptide amphiphiles with immiscible hydrophobic tails were synthesized and their assembly formation was investigated. These pairs formed self-sorting supramolecular fibres using a standard heating–cooling protocol, while one pair with longer hydrophobic tails formed a co-assembly when an additional heating process was applied. ...
DOI:
10.1039/d1cc05560g

16. SRC homology 3 domains: multifaceted binding modules

Author:
Ugo Dionne; Lily J. Percival; François J.M. Chartier; Christian R. Landry; Nicolas Bisson
Source:
Trends in biochemical sciences 2022 v.47 no.9 pp. 772-784
ISSN:
0968-0004
Subject:
peptides,   etc   ; models; separation;     Show all 3 Subjects
Abstract:
... The assembly of complexes following the detection of extracellular signals is often controlled by signaling proteins comprising multiple peptide binding modules. The SRC homology (SH)3 family represents the archetypical modular protein interaction module, with ~300 annotated SH3 domains in humans that regulate an impressive array of signaling processes. We review recent findings regarding the allo ...
DOI:
10.1016/j.tibs.2022.04.005

17. An Organometallic Gold(III) Reagent for ¹⁸F Labeling of Unprotected Peptides and Sugars in Aqueous Media

Author:
James W. McDaniel; Julia M. Stauber; Evan A. Doud; Alexander M. Spokoyny; Jennifer M. Murphy
Source:
Organic letters 2022 v.24 no.28 pp. 5132-5136
ISSN:
1523-7052
Subject:
peptides,   etc   ; air; chemoselectivity; radiolabeling;     Show all 4 Subjects
Abstract:
... The ¹⁸F labeling of unprotected peptides and sugars with a Au(III)–[¹⁸F]fluoroaryl complex is reported. The chemoselective method generates ¹⁸F-labeled S-aryl bioconjugates in an aqueous environment in 15 min with high radiochemical yields and displays excellent functional group tolerance. This approach utilizes an air and moisture stable, robust organometallic Au(III) complex and highlights the v ...
DOI:
10.1021/acs.orglett.2c01965

18. Post-Assembly Modification of Head-to-Tail Cyclic Peptides by Methionine-Directed β-C(sp³)–H Arylation

Author:
Gang Li; Feipeng Yuan; Bo Yao
Source:
Organic letters 2022 v.24 no.31 pp. 5767-5771
ISSN:
1523-7052
Subject:
cyclic peptides,   etc   ; alanine; arylation;     Show all 3 Subjects
Abstract:
... Peptide modification by C(sp³)–H functionalization of internal residues remains a major challenge due to the inhibitory effect of peptide bonds. In this work, we developed a methionine-directed β-C(sp³)–H arylation method for internal alanine functionalization. By tuning the σC–C bond rotation of internal Ala through head-to-tail cyclization, we overcame the inhibitory effect and functionalized a ...
DOI:
10.1021/acs.orglett.2c02253

19. Synergy and sensitivity-balance in concatenating experiments in NO relaxation delay NMR (NORD)

Author:
István Timári; Tamás Milán Nagy; Katalin E. Kövér; Ole W. Sørensen
Source:
Chemical communications 2022 v.58 no.15 pp. 2516-2519
ISSN:
1364-548X
Subject:
peptides,   etc   ; experimental design; metabolomics;     Show all 3 Subjects
Abstract:
... The NMR experiment design strategy of NO Relaxation Delay (NORD), introduced mostly as an idealized theoretical approach, is extended and put to practical use by considering synergy and sensitivity-balance in concatenation of experiments. It is illustrated by a novel experiment, NORD {HMBC}–{HSQC}–{TOCSY}, where magnetization of non-¹³C attached protons effectively is channeled from the TOCSY spec ...
DOI:
10.1039/d1cc06663c

20. Construction of NIR etchable nanoparticles via co-assembly strategy for appointed delivery

Author:
Dong Wang; Zhihao Fan; Haofeng Min; Xinhao Wang; Hui Li; Guangcheng Wei; Jiqian Wang
Source:
Colloids and surfaces 2022 v.648 pp. 129395
ISSN:
0927-7757
Subject:
peptides,   etc   ; cytotoxicity; drugs; irradiation;     Show all 4 Subjects
Abstract:
... NIR etchable nanoparticles were prepared from NIR-triggered molecule (ASBBCM) and short anticancer peptide segment. After NIR irradiation, the surface of nanoparticles became rough according to the TEM observation due to ASBBCM degradation. Since the nanoparticles were gradually destroyed from the surface, functional YSV peptides were released simultaneously. The release rates were closely related ...
DOI:
10.1016/j.colsurfa.2022.129395