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1. Phagocytosis in a Shape-shifting Bacterium

Author:
Gallot-Lavallée, Lucie; Archibald, John M.
Source:
Trends in microbiology 2020 v.28 no.6 pp. 428-430
ISSN:
0966-842X
Subject:
phagocytosis,   etc   ; bacteria; eukaryotic cells;     Show all 3 Subjects
Abstract:
... Phagocytosis – cell ingestion – is an important process confined to eukaryotes. Or is it? Shiratori et al. have discovered the existence of phagocytosis in a planctomycete bacterium, raising new questions about the significance of phagotrophy beyond the realm of eukaryotic life. ...
DOI:
10.1016/j.tim.2020.02.017

2. Effect of scopoletin on phagocytic activity of U937-derived human macrophages: Insights from transcriptomic analysis

Author:
Alkorashy, Amgad I.; Doghish, Ahmed S.; Abulsoud, Ahmed I.; Ewees, Mohamed G.; Abdelghany, Tamer M.; Elshafey, Mostafa M.; Elkhatib, Walid F.
Source:
Genomics 2020 v.112 no.5 pp. 3518-3524
ISSN:
0888-7543
Subject:
phagocytosis,   etc   ; adjuvants; coumarin; gene expression regulation; genes; humans; macrophages; scopoletin; transcription (genetics); transcriptomics;     Show all 10 Subjects
Abstract:
... Scopoletin is a botanical coumarin. Notably, scopoletin effect on phagocytic activity has not been addressed on transcriptomic level. Accordingly, this study investigated the effect of scopoletin on phagocytosis-linked gene transcription. Whole phagocytosis transcriptional profiling of stimulated U937-derived macrophages (SUDMs) in response to scopoletin as compared to non-treated SUDMs was studie ...
DOI:
10.1016/j.ygeno.2020.03.022

3. Live attenuated Edwardsiella ictaluri vaccines enhance the protective innate immune responses of channel catfish B cells

Author:
Kordon, Adef O.; Kalindamar, Safak; Majors, Kara; Abdelhamed, Hossam; Tan, Wei; Karsi, Attila; Pinchuk, Lesya M.
Source:
Developmental and comparative immunology 2020 v.109 pp. 103711
ISSN:
0145-305X
Subject:
phagocytosis,   etc   ; B-lymphocytes; Edwardsiella ictaluri; Ictalurus punctatus; apoptosis; blood serum; catfish; fish diseases; live vaccines; septicemia;     Show all 10 Subjects
Abstract:
... Edwardsiella ictaluri causes enteric septicemia of catfish. Our group developed two E. ictaluri live attenuated vaccines (LAVs). However, their effects on the innate functions of catfish B cells are still unexplored. We evaluated phagocytosis and killing of wild-type (WT) E. ictaluri opsonized with sera from vaccinated fish and the survival of B cells exposed to E. ictaluri strains. We assessed ph ...
DOI:
10.1016/j.dci.2020.103711

4. Phagocytosis activity of three sulfated polysaccharides purified from a marine diatom cultured in a semi-continuous system

Author:
Lai, Hsing-Li; Yang, Li-Chan; Lin, Ping-Ting; Lai, Su-Yuan; Wang, Min-Ying
Source:
International journal of biological macromolecules 2020 v.155 pp. 951-960
ISSN:
0141-8130
Subject:
phagocytosis,   etc   ; Bacillariophyceae; anion exchange chromatography; biomass; fucose; harvesting frequency; macrophages; mice; polysaccharides; sodium carbonate; uronic acids;     Show all 11 Subjects
Abstract:
... An efficient process has been developed for bioactive polysaccharide production and purification from a local diatom isolate, Halamphora sp. AQ4. First, a semi-continuous system with fixed harvesting frequency was employed to cultivate AQ4 for the production of cell mass and polysaccharides for more than 285 days with a high yield of biomass. Six cultivation sets are performed according to differe ...
DOI:
10.1016/j.ijbiomac.2019.11.054

5. Differential influence on antibody dependent cellular phagocytosis by different glycoforms on therapeutic Monoclonal antibodies

Author:
Scott, Kuhns; Kuhns, Scott; Shu, Junyan; Xiang, Cathie; Guzman, Ronandro De; Zhang, Qingchun; Bretzlaff, Will; Miscalichi, Nahira; Kalenian, Kevin; Joubert, Marisa
Source:
Journal of biotechnology 2020 v.317 pp. 5-15
ISSN:
0168-1656
Subject:
phagocytosis,   etc   ; immunoglobulin G; macrophages; mannose; mechanism of action; monoclonal antibodies; neutrophils; reporter genes; therapeutics;     Show all 9 Subjects
Abstract:
... Therapeutic monoclonal antibodies (mAbs), particularly of the IgG1 subclass, are capable of effector function activities that may be important for their mechanism of action. One such effector function activity is Antibody Dependent Cellular Phagocytosis (ADCP), which has been shown to be mediated primarily through the activating FcγR, FcγRIIa, on macrophages and neutrophils. The critical quality a ...
DOI:
10.1016/j.jbiotec.2020.04.017

6. Effects of DCOIT (4,5-dichloro-2-octyl-4-isothiazolin-3-one) to the haemocytes of mussels Perna perna

Author:
Fonseca, Viviane Barneche; Guerreiro, Amanda da Silveira; Vargas, Marcelo Alves; Sandrini, Juliana Zomer
Source:
Comparative biochemistry and physiology 2020 v.232 pp. 108737
ISSN:
1532-0456
Subject:
phagocytosis,   etc   ; DNA damage; Perna perna; biocides; cell viability; hemocytes; immune system; mussels; pollutants; reactive oxygen species;     Show all 10 Subjects
Abstract:
... Bivalve molluscs rely only on an innate immune system to execute cellular and humoral processes. Haemocytes, the haemolymph circulating cells, play a major role in this type of immunity, principally regarding cellular defences. Considering that environmental pollutants can affect the immune system of invertebrates, this work evaluated the effects of the antifouling biocide 4,5-dicloro-2-n-octil-4- ...
DOI:
10.1016/j.cbpc.2020.108737

7. Is CD47 a potentially promising therapeutic target in cardiovascular diseases? — Role of CD47 in cardiovascular diseases

Author:
Cheng, Quanli; Gu, Junlian; Adhikari, Binay Kumar; Sun, Liguang; Sun, Jian
Source:
Life sciences 2020 v.247 pp. 117426
ISSN:
0024-3205
Subject:
phagocytosis,   etc   ; angiogenesis; blood flow; immunoglobulins; ischemia; ligands; macrophages; pathogenesis; reperfusion injury; therapeutics; transmembrane proteins;     Show all 11 Subjects
Abstract:
... CD47 (cluster of differentiation 47) is a ubiquitously expressed transmembrane protein that belongs to the immunoglobulin superfamily. CD47 is both a receptor for the matricellular protein thrombospondin-1 (TSP-1) and a ligand for signal-regulatory protein alpha (SIRPα). Suppression of CD47 activity enhances angiogenesis and blood flow, restores phagocytosis by macrophages, improves ischemic tissu ...
DOI:
10.1016/j.lfs.2020.117426

8. Effect of elasticity on the phagocytosis of micro/nanoparticles

Author:
Yao, Chenyang; Akakuru, Ozioma Udochukwu; Stanciu, Stefan G.; Hampp, Norbert; Jin, Yinhua; Zheng, Jianjun; Chen, Guoping; Yang, Fang; Wu, Aiguo
Source:
Journal of materials chemistry B 2020 v.8 no.12 pp. 2381-2392
ISSN:
2050-7518
Subject:
phagocytosis,   etc   ; blood; cell membranes; chemistry; drugs; membrane fusion; metabolism; nanoparticles; simulation models; tissues;     Show all 10 Subjects
Abstract:
... A broad range of investigation methods and frameworks are currently used to throughly study the elasticity of various types of micro/nanoparticles (MNPs) with different properties and to explore the effect of such properties on their interactions with biological species. Specifically, the elasticity of MNPs serves as a key influencing factor with respect to important aspects of phagocytosis, such ...
DOI:
10.1039/c9tb02902h

9. Expression profile of porcine scavenger receptor A and its role in bacterial phagocytosis by macrophages

Author:
Xiang, Xiao; Zhang, Yanbing; Li, Qianqian; Wei, Jianchao; Liu, Ke; Shao, Donghua; Li, Beibei; Olszewski, Michal A.; Ma, Zhiyong; Qiu, Yafeng
Source:
Developmental and comparative immunology 2020 v.104 pp. 103534
ISSN:
0145-305X
Subject:
phagocytosis,   etc   ; bacteria; cell lines; fucoidan; lungs; macrophages; polyclonal antibodies; recombinant proteins; swine;     Show all 9 Subjects
Abstract:
... Expression of scavenger receptor A (SRA) in macrophages plays key role in macrophage mediated uptake of microbes. However, little is known about the role of porcine scavenger receptor A (pSRA) in phagocytic function of macrophages in swine species. In this study, polyclonal antibody against pSRA was generated by using recombinant proteins to study expression and function of pSRA. We report broad e ...
DOI:
10.1016/j.dci.2019.103534

10. Focal/multifocal and geographic retinal dysplasia in the dog—In vivo retinal microanatomy analyses

Author:
Iwabe, Simone; Dufour, Valerie L.; Guzmán, José M.; Holle, Dolores M.; Cohen, Julie A.; Beltran, William A.; Aguirre, Gustavo D.
Source:
Veterinary ophthalmology 2020 v.23 no.2 pp. 292-304
ISSN:
1463-5216
Subject:
phagocytosis,   etc   ; DNA; anesthesia; breeding; dogs; heterozygosity; image analysis; immunohistochemistry; macrophages; ophthalmology; photoreceptors; retina;     Show all 12 Subjects
Abstract:
... PURPOSE: To examine the in vivo microanatomy of retinal folds and geographic lesions in dogs with acquired or inherited retinal dysplasia. MATERIAL AND METHODS: Thirteen dogs had retinal microanatomy evaluation under general anesthesia using cSLO/sdOCT; two eyes had noninherited multifocal retinal folds, five had inherited multifocal retinal folds (drd1 or drd2), and 10 geographic retinal dysplasi ...
DOI:
10.1111/vop.12725
PubMed:
31746146
PubMed Central:
PMC7071990

11. Complement system and phagocytosis in a colonial protochordate

Author:
Peronato, Anna; Drago, Laura; Rothbächer, Ute; Macor, Paolo; Ballarin, Loriano; Franchi, Nicola
Source:
Developmental and comparative immunology 2020 v.103 pp. 103530
ISSN:
0145-305X
Subject:
phagocytosis,   etc   ; Botryllus schlosseri; antibodies; apoptosis; complement; hemocytes; in situ hybridization; phagocytes; receptors; tissues; zymosan;     Show all 11 Subjects
Abstract:
... In the present work, we investigated, in the colonial ascidian Botryllus schlosseri, the role of complement C3 (BsC3) in phagocytosis. We studied the modulation of BsC3 transcription in the course of the colonial blastogenetic cycle, with particular reference to the takeover, when apoptotic cells in the tissues of old zooids are cleared by circulating phagocytes. In situ hybridisation with BsC3 ri ...
DOI:
10.1016/j.dci.2019.103530

12. Overcoming the challenge of establishing biofilms in vivo: a roadmap for Enterococci

Author:
Ai Zhu Tan, Casandra; Tan, Casandra Ai Zhu; Antypas, Haris; Kline, Kimberly A
Source:
Current opinion in microbiology 2020 v.53 pp. 9-18
ISSN:
1369-5274
Subject:
phagocytosis,   etc   ; Enterococcus faecalis; adhesion; bacteria; biofilm; medical equipment; pathogens; plankton; polymers; quorum sensing;     Show all 10 Subjects
Abstract:
... Enterococcus faecalis forms single and mixed-species biofilms on both tissue and medical devices in the host, often under exposure to fluid flow, giving rise to infections that are recalcitrant to treatment. The factors that drive enterococcal biofilm formation in the host, however, remain unclear. Recent reports in other pathogens show how surface sensing by bacteria can trigger the transition fr ...
DOI:
10.1016/j.mib.2020.01.013

13. Hydra nematocysts in the flatworm Microstomum lineare: in search for alterations preceding their disappearance from the new host

Author:
Krohne, Georg
Source:
Cell and tissue research 2020 v.379 no.1 pp. 63-71
ISSN:
0302-766X
Subject:
phagocytosis,   etc   ; Hydra; Platyhelminthes; acridine orange; dyes; excretion; intestinal mucosa; organelles; polyglutamic acid; staining;     Show all 10 Subjects
Abstract:
... Nematocysts are characteristic organelles of the phylum Cnidaria. The free-living Platyhelminth Microstomum lineare preys on Hydra oligactis and sequesters nematocysts. All nematocyst types become phagocytosed without adherent cytoplasm by intestinal cnidophagocytes. Desmoneme and isorhiza nematocysts disappear within 2 days after ingestion whereas cnidophagocytes containing the venom-loaded steno ...
DOI:
10.1007/s00441-019-03149-w

14. Single cell measurement of calpain activity in neutrophils reveals link to cytosolic Ca2+ elevation and individual phagocytotic events

Author:
Jennings, Samantha; Hallett, Maurice B.
Source:
Biochemical and biophysical research communications 2019 v.515 no.1 pp. 163-168
ISSN:
0006-291X
Subject:
phagocytosis,   etc   ; calcium; calpain; fluorescence; neutrophils; zymosan;     Show all 6 Subjects
Abstract:
... It has been proposed that Ca2+ activation of calpain-1 is important for the rapid cell shape changes which accompany phagocytosis. In this paper, we use a fluorogenic calpain substrate, (CBZ-Ala Ala)2 R110, and find that there was a low calpain activity measureable in resting (ie without intentional activation) neutrophils, but that it was accelerated by an elevation of cytosolic free Ca2+ (ionomy ...
DOI:
10.1016/j.bbrc.2019.05.125

15. The extracellular thioredoxin Etrx3 is required for macrophage infection in Rhodococcus equi

Author:
Mourenza, Álvaro; Collado, Cristina; Bravo-Santano, Natalia; Gil, José A.; Mateos, Luís M.; Letek, Michal
Source:
Veterinary research 2020 v.51 no.1 pp. 38
ISSN:
1297-9716
Subject:
phagocytosis,   etc   ; Rhodococcus equi; drug therapy; extracellular enzymes; genes; homeostasis; macrophages; mutants; pathogens; sodium hypochlorite; survival rate; thioredoxins;     Show all 12 Subjects
Abstract:
... Rhodococcus equi is an intracellular veterinary pathogen that is becoming resistant to current antibiotherapy. Genes involved in preserving redox homeostasis could be promising targets for the development of novel anti-infectives. Here, we studied the role of an extracellular thioredoxin (Etrx3/REQ_13520) in the resistance to phagocytosis. An etrx3-null mutant strain was unable to survive within m ...
DOI:
10.1186/s13567-020-00763-3
PubMed:
32156317
PubMed Central:
PMC7063783

16. Identification of β tubulin IVb as a pattern recognition receptor with opsonic activity

Author:
Duan, Huimin; Yang, Shuaiqi; Ni, Shousheng; Ma, Zengyu; Yuan, Jianrui; Zhang, Shicui
Source:
Comparative biochemistry and physiology 2020 v.235 pp. 108781
ISSN:
1532-0456
Subject:
phagocytosis,   etc   ; Danio rerio; bacteria; blood serum; genes; immune response; macrophages; mechanism of action; mice; plants (botany); tubulin;     Show all 11 Subjects
Abstract:
... Previous studies have shown that tubulins play important role in immune responses of both plants and animals, but no experiments have been performed to study the mode of action of tubulins in immune defense. In addition, there is little convincing experimental evidence of functional commitment for specific tubulin isotypes in animals. In the present, we showed that expression of β-tubulin IVb gene ...
DOI:
10.1016/j.cbpc.2020.108781

17. Immunological Activities of Crude Polysaccharides Extracts of Climacodon pulcherrimus (Phanerochaetaceae) in Lipopolysaccharide-Induced Rat Macrophages and Neutrophils' Responses

Author:
Christopher, Tume; Mahamat, Oumar; Chungong, Miyanui N.; Ngwa, C. Atemenkeh; Samka, P. Maishu
Source:
Journal of medicinal food 2020
ISSN:
1557-7600
Subject:
phagocytosis,   etc   ; Phanerochaetaceae; acid phosphatase; adhesion; cytotoxicity; exopolysaccharides; macrophages; mechanism of action; mushrooms; myeloperoxidase; neutrophils; nitric oxide; reactive oxygen species; secretion;     Show all 14 Subjects
Abstract:
... Mushroom contains a wide variety of components with high immune-modulating properties. Mushroom polysaccharides are known as immunocorrectors with wide areas of usage, which balance the immune system without resulting in the entire immune suppression or overreaction. To explore the potentially immunomodulatory role of Climacodon pulcherrimus, the present study was intended to evaluate the in vitro ...
DOI:
10.1089/jmf.2020.0005

18. Structural characterization and immunomodulatory activity of an exopolysaccharide produced by Lactobacillus helveticus LZ-R-5

Author:
You, Xiu; Li, Zhi; Ma, Kai; Zhang, Changliang; Chen, Xiaohong; Wang, Guangxian; Yang, Lin; Dong, Mingsheng; Rui, Xin; Zhang, Qiuqin; Li, Wei
Source:
Carbohydrate polymers 2020 v.235 pp. 115977
ISSN:
0144-8617
Subject:
phagocytosis,   etc   ; Lactobacillus helveticus; acid phosphatase; anion exchange; cell proliferation; cellulose; cytokines; enzyme activity; exopolysaccharides; fermented milk; immunostimulants; macrophages; nitric oxide;     Show all 13 Subjects
Abstract:
... Exopolysaccharide (R-5-EPS) was isolated from the fermented milk of Lactobacillus helveticus LZ-R-5 and purified by DEAE-52 cellulose anion-exchange column, and characterization of the structure was conducted. Results showed that R-5-EPS was a heteropolysaccharide containing linear repeating units of →6)-β-D-Galp-(1→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→ with an average Mw of ...
DOI:
10.1016/j.carbpol.2020.115977

19. Conservation of eATP perception throughout multicellular animal evolution: Identification and functional characterization of coral and amphioxus P2X7-like receptors and flounder P2X7 receptor

Author:
Duan, Huimin; Ni, Shousheng; Yang, Shuaiqi; Zhou, Yang; Zhang, Yu; Zhang, Shicui
Source:
Developmental and comparative immunology 2020 v.106 pp. 103641
ISSN:
0145-305X
Subject:
phagocytosis,   etc   ; adenosine triphosphate; corals; flounder; humans; interleukin-1beta; interleukin-6; interleukin-8; plasma membrane; receptors; signal transduction;     Show all 11 Subjects
Abstract:
... Perception of extracellular ATP (eATP), a common endogenous damage-associated molecular pattern, is through its receptor P2X7R. If eATP/P2X7R signaling is conserved throughout animal evolution is unknown. Moreover, little information is currently available regarding P2X7R in invertebrates. Here we demonstrated that the coral P2X7-like receptor, AdP2X7RL, the amphioxus P2X7-like receptor, BjP2X7RL ...
DOI:
10.1016/j.dci.2020.103641

20. Nanoplastics: From tissue accumulation to cell translocation into Mytilus galloprovincialis hemocytes. resilience of immune cells exposed to nanoplastics and nanoplastics plus Vibrio splendidus combination

Author:
Sendra, M.; Saco, A.; Yeste, M.P.; Romero, A.; Novoa, B.; Figueras, A.
Source:
Journal of hazardous materials 2020 v.388 pp. 121788
ISSN:
0304-3894
Subject:
phagocytosis,   etc   ; Mytilus galloprovincialis; Vibrio splendidus; antimicrobial peptides; apoptosis; bacteria; clathrin; hemocytes; in vitro studies; in vivo studies; muscles; nanoplastics; polystyrenes;     Show all 13 Subjects
Abstract:
... Plastic litter is an issue of global concern. In this work Mytilus galloprovincialis was used to study the distribution and effects of polystyrene nanoplastics (PS NPs) of different sizes (50 nm, 100 nm and 1 μm) on immune cells. Internalization and translocation of NPs to hemolymph were carried out by in vivo experiments, while endocytic routes and effects of PS NPs on hemocytes were studied in v ...
DOI:
10.1016/j.jhazmat.2019.121788