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1. Single cell measurement of calpain activity in neutrophils reveals link to cytosolic Ca2+ elevation and individual phagocytotic events

Author:
Jennings, Samantha; Hallett, Maurice B.
Source:
Biochemical and biophysical research communications 2019 v.515 no.1 pp. 163-168
ISSN:
0006-291X
Subject:
phagocytosis,   etc   ; calcium; calpain; fluorescence; neutrophils; zymosan;     Show all 6 Subjects
Abstract:
... It has been proposed that Ca2+ activation of calpain-1 is important for the rapid cell shape changes which accompany phagocytosis. In this paper, we use a fluorogenic calpain substrate, (CBZ-Ala Ala)2 R110, and find that there was a low calpain activity measureable in resting (ie without intentional activation) neutrophils, but that it was accelerated by an elevation of cytosolic free Ca2+ (ionomy ...
DOI:
10.1016/j.bbrc.2019.05.125

2. Microglia promote the proliferation of neural precursor cells by secreting osteopontin

Author:
Yamamiya, Miwako; Tanabe, Shogo; Muramatsu, Rieko
Source:
Biochemical and biophysical research communications 2019 v.513 no.4 pp. 841-845
ISSN:
0006-291X
Subject:
phagocytosis,   etc   ; antibodies; apoptosis; brain; coculture; integrins; neuroglia; osteopontin;     Show all 8 Subjects
Abstract:
... Microglia are central nervous system-resident immune cells that play a crucial role in brain development by interacting with neural precursor cells (NPCs). It has been reported that microglia regulate the number of NPC by phagocytosis, inducing apoptosis, and promoting proliferation. Microglia surrounding the subventricular zone express osteopontin (OPN) during brain development. The present study ...
DOI:
10.1016/j.bbrc.2019.04.076

3. Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity

Author:
Zent, Clive S.; Elliott, Michael R.
Source:
The FEBS journal 2017 v.284 no.7 pp. 1021-1039
ISSN:
1742-464X
Subject:
phagocytosis,   etc   ; apoptosis; macrophages;     Show all 3 Subjects
Abstract:
... The phagocytic clearance of host cells is important for eliminating dying cells and for the therapeutic clearance of antibody‐targeted cells. As ubiquitous, motile and highly phagocytic immune cells, macrophages are principal players in the phagocytic removal of host cells throughout the body. In recent years, great strides have been made in identifying the molecular mechanisms that control the re ...
DOI:
10.1111/febs.13961
PubMed:
27863012
PubMed Central:
PMC5378628

4. Tsc1 controls the development and function of alveolar macrophages

Author:
Chen, Song; Yang, Qiongmei; Liu, Jingru; Huang, Huifang; Shi, Mingxia; Feng, Xiaoming
Source:
Biochemical and biophysical research communications 2018 v.498 no.3 pp. 592-596
ISSN:
0006-291X
Subject:
phagocytosis,   etc   ; homeostasis; lungs; macrophages; reactive oxygen species;     Show all 5 Subjects
Abstract:
... Alveolar macrophages (AMs) are pivotal for maintaining the lung homeostasis, but how the development and function of AMs regulated remains largely unknown. In the present study, we demonstrated that the number of AMs was controlled by the Tsc1 protein. Cd11c-specific deletion of Tsc1 caused inefficient transition from pre-AMs to AMs in lung, which led to a great reduction of AM population. Ablatio ...
DOI:
10.1016/j.bbrc.2018.03.027

5. Cortex glia clear dead young neurons via Drpr/dCed-6/Shark and Crk/Mbc/dCed-12 signaling pathways in the developing Drosophila optic lobe

Author:
Nakano, Ryosuke; Iwamura, Masashi; Obikawa, Akiko; Togane, Yu; Hara, Yusuke; Fukuhara, Toshiyuki; Tomaru, Masatoshi; Takano-Shimizu, Toshiyuki; Tsujimura, Hidenobu
Source:
Developmental biology 2019 v.453 no.1 pp. 68-85
ISSN:
0012-1606
Subject:
phagocytosis,   etc   ; Drosophila; apoptosis; cortex; instars; larvae; ligands; neurites; optic lobe; phosphatidylserines; pupae; signal transduction;     Show all 12 Subjects
Abstract:
... The molecular and cellular mechanism for clearance of dead neurons was explored in the developing Drosophila optic lobe. During development of the optic lobe, many neural cells die through apoptosis, and corpses are immediately removed in the early pupal stage. Most of the cells that die in the optic lobe are young neurons that have not extended neurites. In this study, we showed that clearance wa ...
DOI:
10.1016/j.ydbio.2019.05.003

6. A versatile high-throughput assay to characterize antibody-mediated neutrophil phagocytosis

Author:
Karsten, Christina B.; Mehta, Nickita; Shin, Sally A.; Diefenbach, Thomas J.; Slein, Matthew D.; Karpinski, Wiktor; Irvine, Edward B.; Broge, Thomas; Suscovich, Todd J.; Alter, Galit
Source:
Journal of immunological methods 2019 v.471 pp. 46-56
ISSN:
0022-1759
Subject:
phagocytosis,   etc   ; antibodies; antigens; blood serum; enzymes; flow cytometry; immunologic receptors; immunomodulators; neutrophils; secretion;     Show all 10 Subjects
Abstract:
... Neutrophils, the most abundant white blood cell, play a critical role in anti-pathogen immunity via phagocytic clearance, secretion of enzymes and immunomodulators, and the release of extracellular traps. Neutrophils non-specifically sense infection through an array of innate immune receptors and inflammatory sensors, but are also able to respond in a pathogen/antigen-specific manner when leverage ...
DOI:
10.1016/j.jim.2019.05.006

7. Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14

Author:
Skjeflo, E.W.; Christiansen, D.; Landsem, A.; Stenvik, J.; Woodruff, T.M.; Espevik, T.; Nielsen, E.W.; Mollnes, T.E.
Source:
Molecular immunology 2019 v.112 pp. 131-139
ISSN:
0161-5890
Subject:
phagocytosis,   etc   ; Escherichia coli; Gram-positive bacteria; Staphylococcus aureus; antagonists; complement; cytokines; flow cytometry; humans; inflammation; monocytes;     Show all 11 Subjects
Abstract:
... Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-negative and Gram-positive bacteria in human whole blood.Lepirudin-anticoagulated blood was incubated with live or dead E. coli or S. aureus at 37 °C for 120 min with or without the C5aR1 antagonist PMX53 and/or anti-CD14 ...
DOI:
10.1016/j.molimm.2019.03.014

8. Soluble defense collagens: Sweeping up immune threats

Author:
Casals, Cristina; García-Fojeda, Belén; Minutti, Carlos M.
Source:
Molecular immunology 2019 v.112 pp. 291-304
ISSN:
0161-5890
Subject:
phagocytosis,   etc   ; adiponectin; blood serum; collagen; complement; inflammation; macrophages; pathogens; protein secretion; surfactant proteins; tissue repair;     Show all 11 Subjects
Abstract:
... Soluble defense collagens form a group of secreted proteins that are primarily involved in host defense. All defense collagens contain a globular recognition domain contiguous to a collagen-like triple helical domain. They are oligomeric proteins, assembled in multiples of three subunits due to their collagen domains. Members of this group include collectins such as surfactant protein A and D (SP- ...
DOI:
10.1016/j.molimm.2019.06.007

9. Increased phagocytosis and growth inhibition of Encephalitozoon cuniculi by LPS-activated J774A.1 murine macrophages

Author:
González-Machorro, J. R.; Rodríguez-Tovar, L. E.; Gómez-Flores, R.; Soto-Dominguez, A.; Rodríguez-Rocha, H.; Garcia-García, A.; Tamez-Guerra, P.; Castillo-Velázquez, U.
Source:
Parasitology research 2019 v.118 no.6 pp. 1841-1848
ISSN:
0932-0113
Subject:
phagocytosis,   etc   ; Encephalitozoon cuniculi; formalin; growth retardation; heat treatment; humans; lipopolysaccharides; macrophages; mice; parasites; spores; viability;     Show all 12 Subjects
Abstract:
... Encephalitozoon cuniculi is an obligate macrophage parasite of vertebrates that commonly infects rodents, monkeys, dogs, birds, and humans. In the present study, we aimed to assess the phagocytosis and intracellular survival of E. cuniculi spores using untreated and lipopolysaccharide (LPS)-activated J774A.1 murine macrophages and assess the macrophage viability. The experimental groups comprised ...
DOI:
10.1007/s00436-019-06310-0

10. Phagocytosis in Drosophila: From molecules and cellular machinery to physiology

Author:
Melcarne, C.; Lemaitre, B.; Kurant, E.
Source:
Insect biochemistry and molecular biology 2019 v.109 pp. 1-12
ISSN:
0965-1748
Subject:
phagocytosis,   etc   ; Drosophila melanogaster; apoptosis; bacteria; fruit flies; homeostasis; pathogens; phagocytes; phagosomes; plasma membrane; receptors;     Show all 11 Subjects
Abstract:
... Phagocytosis is an evolutionarily conserved mechanism that plays a key role in both host defence and tissue homeostasis in multicellular organisms. A range of surface receptors expressed on different cell types allow discriminating between self and non-self (or altered) material, thus enabling phagocytosis of pathogens and apoptotic cells. The phagocytosis process can be divided into four main ste ...
DOI:
10.1016/j.ibmb.2019.04.002

11. The different morphologies of yeast and filamentous fungi trigger distinct killing and feeding mechanisms in a fungivorous amoeba

Author:
Radosa, Silvia; Ferling, Iuliia; Sprague, Jakob L.; Westermann, Martin; Hillmann, Falk
Source:
Environmental microbiology 2019 v.21 no.5 pp. 1809-1820
ISSN:
1462-2912
Subject:
phagocytosis,   etc   ; Aspergillus fumigatus; Basidiomycota; Candida albicans; animal pathogens; cell walls; fungivores; germination; hyphae; phagocytes; spores; yeasts;     Show all 12 Subjects
Abstract:
... Size and diverse morphologies pose a primary challenge for phagocytes such as innate immune cells and predatory amoebae when encountering fungal prey. Although filamentous fungi can escape phagocytic killing by pure physical constraints, unicellular spores and yeasts can mask molecular surface patterns or arrest phagocytic processing. Here, we show that the fungivorous amoeba Protostelium aurantiu ...
DOI:
10.1111/1462-2920.14588

12. Synthesis and Evaluation of Oligomeric Thioether-Linked Carbacyclic β-(1→3)-Glucan Mimetics

Author:
Wen, Peng; Větvička, Václav; Crich, David
Source:
Journal of organic chemistry 2019 v.84 no.9 pp. 5554-5563
ISSN:
1520-6904
Subject:
phagocytosis,   etc   ; carboxylic acids; chemical reactions; chemical structure; humans; hydrophobicity; isothiocyanates; macrophages; mice; neutrophils; organic chemistry; staining;     Show all 12 Subjects
Abstract:
... Extrapolating from lessons learnt with previous low-molecular-weight β-(1→3)-glucan mimetics, we designed a series of minimal 2,4-dideoxy-thioether-linked carbacyclic β-(1→3)-glucan mimetics and synthesized di-, tri-, and tetramers in an enantiomerically pure form by an iterative sequence based on a simple building block readily available from commercial (S)-(−)-3-cyclohexenecarboxylic acid. These ...
DOI:
10.1021/acs.joc.9b00504

13. Biodurability and release of metals during the dissolution of chrysotile, crocidolite and fibrous erionite

Author:
Gualtieri, Alessandro F.; Lusvardi, Gigliola; Zoboli, Alessandro; Di Giuseppe, Dario; Lassinantti Gualtieri, Magdalena
Source:
Environmental research 2019 v.171 pp. 550-557
ISSN:
0013-9351
Subject:
phagocytosis,   etc   ; adverse effects; chromium; hydroxyl radicals; iron; lungs; manganese; nanoparticles; nickel; synthetic fibers; toxicity; zeolites;     Show all 12 Subjects
Abstract:
... The mechanisms by which mineral fibers induce adverse effects in vivo are still not well understood. The mechanisms of fiber dissolution in the lungs and subsequent release of metals in the extracellular/intracellular environment must be taken into account.For the first time, the kinetics of release of metals during the acellular in vitro dissolution of chrysotile, crocidolite and fibrous erionite ...
DOI:
10.1016/j.envres.2019.01.011

14. Morphological changes and phagocytic activity during the interaction of human neutrophils with Sporothrix schenckii: An in vitro model

Author:
Curtiellas-Piñol, Vicente; Ventura-Juárez, Javier; Ruiz-Baca, Estela; Romo-Lozano, Yolanda
Source:
Microbial pathogenesis 2019 v.129 pp. 56-63
ISSN:
0882-4010
Subject:
phagocytosis,   etc   ; Sporothrix schenckii; coculture; conidia; histopathology; humans; models; morphs; neutrophils; scanning electron microscopy; viability; yeasts;     Show all 12 Subjects
Abstract:
... Histopathological studies of human sporotrichosis lesions show pyogenic and granulomatous processes in which polymorphonuclear neutrophils (PMNs) play a central role. Few studies regarding the events associated with the interaction of human PMNs with Sporothrix schenckii have been made despite their importance in the clinical manifestations of the disease. In this study, human PMNs were co-culture ...
DOI:
10.1016/j.micpath.2019.01.041

15. Disparate effects of PEG or albumin based surface modification on the uptake of nano- and micro-particles

Author:
Sharma, Preeti; Sen, Devashish; Neelakantan, Varsha; Shankar, Vinidhra; Jhunjhunwala, Siddharth
Source:
Biomaterials science 2019 v.7 no.4 pp. 1411-1421
ISSN:
2047-4849
Subject:
phagocytosis,   etc   ; albumins; blood proteins; coatings; microparticles; nanoparticles; particle size; polyethylene glycol; polystyrenes;     Show all 9 Subjects
Abstract:
... Surface modification of particulate systems is a commonly employed strategy to alter their interaction with proteins and cells. Past studies on nano-particles have shown that surface functionalization with polyethylene glycol (PEG) or proteins such as albumin increases circulation times by reducing their phagocytic uptake. However, studies on surface functionalized micro-particles have reported co ...
DOI:
10.1039/c8bm01545g

16. Amoebae Assemble Synthetic Spherical Particles To Form Reproducible Constructs

Author:
Bian, Pei; Strano, Joseph; Zheng, Peiwen; Steinitz-Kannan, Miriam; Clarson, Stephen J.; Kannan, Ramamurthi; McCarthy, Thomas J.
Source:
Langmuir 2019 v.35 no.14 pp. 5069-5074
ISSN:
1520-5827
Subject:
phagocytosis,   etc   ; construction materials; electron microscopy; environmental impact; inorganic matter; microparticles; photography; pollutants; polystyrenes; silica; taxonomy;     Show all 11 Subjects
Abstract:
... Difflugia are testate amoebae that use particulate inorganic matter to build a protective shell (generally called a test or theca). Difflugia globulosa were grown both in culture containing only naturally occurring theca-building materials and under conditions where synthetic particles were present also. The presence of monodisperse Stöber silica microspheres of 1, 3, and 6 μm in diameter or 4 μm ...
DOI:
10.1021/acs.langmuir.9b00333

17. Electrochemical Measurements of Reactive Oxygen and Nitrogen Species inside Single Phagolysosomes of Living Macrophages

Author:
Hu, Keke; Li, Yun; Rotenberg, Susan A.; Amatore, Christian; Mirkin, Michael V.
Source:
Journal of the American Chemical Society 2019 v.141 no.11 pp. 4564-4568
ISSN:
1520-5126
Subject:
phagocytosis,   etc   ; carbon; electrochemistry; hydrogen peroxide; interferon-gamma; lipopolysaccharides; macrophages; mice; nitric oxide; nitrites; nitrogen; oxygen; phagosomes;     Show all 13 Subjects
Abstract:
... The release of reactive oxygen and nitrogen species (ROS/RNS) by macrophages undergoing phagocytosis is crucial for the efficiency of the immune system. In this work, platinized carbon nanoelectrodes were used to detect, characterize, and quantify for the first time the intracellular production rates of the four primary ROS/RNS (i.e., H₂O₂, ONOO–, NO•, and NO₂–) inside single phagolysosomes of liv ...
DOI:
10.1021/jacs.9b01217

18. Isolation of colloidal particles from porcine bone soup and their interaction with murine peritoneal macrophage

Author:
Wang, Huiqin; Gao, Guanzhen; Ke, Lijing; Zhou, Jianwu; Rao, Pingfan; Jin, Yongyang; He, Lei; Wan, Jennifer; Wang, Qiang
Source:
Journal of functional foods 2019 v.54 pp. 403-411
ISSN:
1756-4646
Subject:
phagocytosis,   etc   ; antioxidant activity; chromatography; colloids; gastrointestinal system; macrophages; mice; mitochondria; nanoparticles; soups; swine;     Show all 11 Subjects
Abstract:
... Food nanoparticles have recently been identified to be engulfed by oral macrophages conducting antioxidant effects. It suggests an important but long overlooked food-body interaction and prompts the importance of the correlated methodology development. As oral macrophages are restricted in numbers, peritoneal macrophages can provide an alternative for its easy availability and its role in the gast ...
DOI:
10.1016/j.jff.2019.01.021

19. Pathogenicity differences of Salmonella enterica serovars Typhimurium, Enteritidis, and Choleraesuis-specific virulence plasmids and clinical S. Choleraesuis strains with large plasmids to the human THP-1 cell death

Author:
Huang, Yao-Kuang; Chen, Sheng-Ya; Wong, Min Yi; Chiu, Cheng-Hsun; Chu, Chishih
Source:
Microbial pathogenesis 2019 v.128 pp. 69-74
ISSN:
0882-4010
Subject:
phagocytosis,   etc   ; Salmonella Typhimurium; apoptosis; cytotoxicity; flow cytometry; humans; necrosis; pathogens; plasmids; serotypes; swine; virulence;     Show all 12 Subjects
Abstract:
... Salmonella is a common foodborne and zoonotic pathogen. Only a few serovars carry a virulence plasmid (pSV), which enhances the pathogenicity of the host. Here, we investigated the pathogenicity roles of the pSVs among wild-type, plasmid-less, and complemented S. Typhimurium, S. Enteritidis S. Choleraesuis in invasion, phagocytosis, and intracellular bacterial survival in human THP-1 cells and cel ...
DOI:
10.1016/j.micpath.2018.12.035

20. Prodegradant Additives Effect onto Comercial Polyolefins

Author:
Vazquez, Y. V.; Ressia, J. A.; Cerrada, M. L.; Barbosa, S. E.; Vallés, E. M.
Source:
Journal of polymers and the environment 2019 v.27 no.3 pp. 464-471
ISSN:
1566-2543
Subject:
phagocytosis,   etc   ; additives; biodegradation; cleavage (chemistry); cutting; mechanical properties; microorganisms; molecular weight; polyethylene;     Show all 9 Subjects
Abstract:
... Prodegradant additives (PDA) came up in the last few decades as a possible solution to the low degradability of polyolefins. PDAs attack polyolefins chains cutting and degrading them to a degree that eventually may allow phagocytosis by microorganisms. Also, considering that the PDA is added in very low quantities, main additives suppliers affirm that a priori they neither alter mechanical propert ...
DOI:
10.1007/s10924-018-01364-0