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1. An update on microcrystalline cellulose in direct compression: Functionality, critical material attributes, and co-processed excipients

Author:
Haiyue Zhao; Lijie Zhao; Xiao Lin; Lan Shen
Source:
Carbohydrate polymers 2022 v.278 pp. 118968
ISSN:
0144-8617
Subject:
pharmaceutical industry,   etc   ; cellulose; flavor; lubricants;     Show all 4 Subjects
Abstract:
... Microcrystalline cellulose (MCC) is one of the most popular cellulose derivatives in the pharmaceutical industry. Thanks to its outstanding tabletability, MCC is generally included in direct compression (DC) tablet formulations containing poor-tabletability active pharmaceutical ingredients. Nowadays, numerous grades of MCC from various brands are accessible for pharmaceutical manufacturers, leadi ...
DOI:
10.1016/j.carbpol.2021.118968

2. Ni-Catalyzed Asymmetric Hydrogenation of Aromatic Ketoacids for the Synthesis of Chiral Lactones

Author:
Chen-Qiang Deng; Jin Deng
Source:
Organic letters 2022 v.24 no.13 pp. 2494-2498
ISSN:
1523-7052
Subject:
pharmaceutical industry,   etc   ; catalysts; hydrogenation; lactones;     Show all 4 Subjects
Abstract:
... A highly efficient Ni-catalyzed asymmetric hydrogenation of aromatic γ- and δ-ketoacids has been developed, affording a series of γ- and δ-aryl lactones in high yields and excellent enantioselectivities (≤98% ee). The hydrogenation could occur smoothly on a gram scale with 0.05 mol % catalyst loading (S/C = 2000). This protocol provides an efficient and practical approach for accessing chiral lact ...
DOI:
10.1021/acs.orglett.2c00608

3. Solventborne Polymer Coatings: Drying, Film Formation, Stress Evolution, and Failure

Author:
Mahesh S. Tirumkudulu; Venugopala Swami Punati
Source:
Langmuir 2022 v.38 no.8 pp. 2409-2414
ISSN:
1520-5827
Subject:
pharmaceutical industry,   etc   ; lithium batteries; polymers; solar cells;     Show all 4 Subjects
Abstract:
... Polymer coatings find use in a wide range of industrial applications, from conventional paints and coatings in building and construction to the pharmaceutical industry, organic solar cell production, and lithium battery technology. Despite their importance, there are gaps in our understanding of the drying process, the stress development during drying, and their influence on the final mechanical p ...
DOI:
10.1021/acs.langmuir.1c03124

4. Metabolite-based biosensors for natural product discovery and overproduction

Author:
Sanyuan Shi; Yuhui Xie; Gaoli Wang; Yunzi Luo
Source:
Current opinion in biotechnology 2022 v.75 pp. 102699
ISSN:
0958-1669
Subject:
pharmaceutical industry,   etc   ; biosensors; biosynthesis; biotechnology; heterologous gene expression; secondary metabolites;     Show all 6 Subjects
Abstract:
... Natural products derived from bacterial secondary metabolites contribute greatly to the pharmaceutical industry. Heterologous expression of natural product biosynthetic pathways can remarkably improve the yield of target products and lead to the discovery of numerous derivatives. Therefore, high-throughput analytical methods are urgently needed for the detection of natural products. Biosensors all ...
DOI:
10.1016/j.copbio.2022.102699

5. Potential biotherapeutic properties of lactic acid bacteria in foods

Author:
Zerrin Erginkaya; Gözde Konuray-Altun
Source:
Food bioscience 2022 v.46 pp. 101544
ISSN:
2212-4292
Subject:
pharmaceutical industry,   etc   ; dietary supplements; food composition; lactic acid; probiotics; therapeutics;     Show all 6 Subjects
Abstract:
... Today, the use of microorganisms to produce substances that can be consumable, used as a food ingredient and have a positive effect on consumer health is attracting attention and studies in this field are increasing. Besides, the therapeutic products produced by lactic acid bacteria (LAB) can be used in the food and pharmaceutical industry to create desirable characteristics of foods. In addition ...
DOI:
10.1016/j.fbio.2022.101544

6. A μ-QuEChERS method combined with UHPLC-MS/MS for the analysis of phenolic compounds in red pepper varieties

Author:
Carina Alexandra Rodrigues; Ana Paula Lourenção Zomer; Eliza Mariane Rotta; Jesuí Vergílio Visentainer; Liane Maldaner
Source:
Journal of food composition and analysis 2022 pp. 104647
ISSN:
0889-1575
Subject:
pharmaceutical industry,   etc   ; cost effectiveness; food composition; health promotion; naringenin; pepper; India;     Show all 7 Subjects
Abstract:
... In this study, a method based on QuEChERS method miniaturization followed by UHPLC-MS/MS analysis was used for the first time to determine phenolic acids and flavonoids in red pepper (Capsicum spp.). Under the optimized extraction and analysis conditions, fourteen phenolic compounds in eleven varieties of red pepper belonging to four domesticated species, C. baccatum L., C. chinense Jacq., C. frut ...
DOI:
10.1016/j.jfca.2022.104647

7. Polyanionic Cyclodextrin-Induced Supramolecular Assembly of a Cationic Tetraphenylethylene Derivative with Aggregation-Induced Emission

Author:
Jasvir Kaur; Dinesh N. Nadimetla; Sheshanath V. Bhosale; Prabhat K. Singh
Source:
Journal of physical chemistry 2022 v.126 no.5 pp. 1147-1155
ISSN:
1520-5207
Subject:
pharmaceutical industry,   etc   ; absorbance; fluorescence; ionic strength; pH; physical chemistry; stoichiometry; temperature;     Show all 8 Subjects
Abstract:
... The combination of supramolecular chemistry and aggregation-induced emission-based luminogens (AIEgens) has recently attracted tremendous attention because of its ability to offer large emission enhancement even in substantially dilute solutions. In this work, a new aggregation-induced emission (AIE)-based supramolecular assembly has been reported, which consists of a polyanionic cyclodextrin deri ...
DOI:
10.1021/acs.jpcb.1c09780

8. Dendritic structured palladium complexes: magnetically retrievable, highly efficient heterogeneous nanocatalyst for Suzuki and Heck cross-coupling reactions

Author:
Safoora Sheikh; Mohammad Ali Nasseri; Mohammad Chahkandi; Oliver Reiser; Ali Allahresani
Source:
RSC advances 2022 v.12 no.15 pp. 8833-8840
ISSN:
2046-2069
Subject:
pharmaceutical industry,   etc   ; catalytic activity; cross-coupling reactions; magnetism; nanocatalysts; palladium; polymers; solubility;     Show all 8 Subjects
Abstract:
... The recyclable nanomagnetic Pd-complex PAMAM G₀-Pd@γ-Fe₂O₃ is reported for catalytic C–C cross-coupling reactions of challenging substrates. Mainly, a great variety of aryl chlorides can be used as substrates for Suzuki–Miyaura and Mizoroki–Heck reactions under mild reaction conditions (60–90 °C) and low catalyst loading (<1 mol% Pd) in aqueous media. The presence of numerous polar groups in the p ...
DOI:
10.1039/d2ra00487a

9. How to reduce CO2 emissions in pharmaceutical industry of China: Evidence from total-factor carbon emissions performance

Author:
Mengmeng Xu; Ruipeng Tan
Source:
Journal of cleaner production 2022 v.337 pp. 130505
ISSN:
0959-6526
Subject:
pharmaceutical industry,   etc   ; carbon; carbon dioxide; energy; issues and policy; leadership; longevity; China;     Show all 8 Subjects
Abstract:
... With China's aspiration of building a healthy nation and increasing its average life expectancy, the pharmaceutical industry will continue to grow in the coming years. Considering the high energy consumption and emissions in the pharmaceutical industry, striving for sustainability will be essential to achieving the 2030 target of peaking CO₂ emissions and becoming carbon neutral by 2060. This pape ...
DOI:
10.1016/j.jclepro.2022.130505

10. In vivo production of pederin by labrenzin pathway expansion

Author:
Dina Kačar; Carmen Schleissner; Librada M. Cañedo; Pilar Rodríguez; Fernando de la Calle; Carmen Cuevas; Beatriz Galán; José Luis García
Source:
Metabolic Engineering Communications 2022 v.14 pp. e00198
ISSN:
2214-0301
Subject:
pharmaceutical industry,   etc   ; Labrenzia; Paederus; aquatic bacteria; biosynthesis; endosymbionts; fermentation; genes; polyketides; toxins;     Show all 10 Subjects
Abstract:
... Pederin is a potent polyketide toxin that causes severe skin lesions in humans after contact with insects of genus Paederus. Due to its potent anticancer activities, pederin family compounds have raised the interest of pharmaceutical industry. Despite the extensive studies on the cluster of biosynthetic genes responsible for the production of pederin, it has not yet been possible to isolate and cu ...
DOI:
10.1016/j.mec.2022.e00198

11. Photocatalytic degradation of Penicillin G in aqueous solutions: Kinetic, degradation pathway, and microbioassays assessment

Author:
Mohammed Berkani; Anfel Smaali; Yassine Kadmi; Fares Almomani; Yasser Vasseghian; Nadjem Lakhdari; Mohamed Alyane
Source:
Journal of hazardous materials 2022 v.421 pp. 126719
ISSN:
0304-3894
Subject:
pharmaceutical industry,   etc   ; Bacillus subtilis; benzylpenicillin; catalysts; pH; photocatalysis; photolysis; pollutants; sodium; toxicity;     Show all 10 Subjects
Abstract:
... The photocatalytic degradation of pharmaceutical micropollutants of Penicillin G (PG) was investigated in a photoreactor at a laboratory scale. The impact of type of catalyst, pH, and initial concentration of PG were studied. Maximum removal efficiency was obtained at pH = 6.8, [ZnO]₀ = 0.8 g L⁻¹, and [PG]₀ = 5 mg L⁻¹ and reaction time of 150 min. The addition of persulfate sodium (PPS) enhanced t ...
DOI:
10.1016/j.jhazmat.2021.126719

12. Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine

Author:
Sareh Bagheri-Josheghani; Bita Bakhshi
Source:
International journal of biological macromolecules 2022 v.208 pp. 494-508
ISSN:
0141-8130
Subject:
pharmaceutical industry,   etc   ; Vibrio cholerae; biosynthesis; encapsulation; interleukin-10; interleukin-6; lipopolysaccharides; pH; selenium;     Show all 9 Subjects
Abstract:
... The lipopolysaccharide (LPS) of Vibrio cholerae plays a significant role in stimulating primary protection and immune responses. LPS delivery has been limited by the stimulation of inflammatory cytokines. This work aimed to report the synthesis and performance of this formulation in modulating immune responses and protecting LPS against acidic gastric medium. Alg-Cs-LPS-SeNPs composite was fabrica ...
DOI:
10.1016/j.ijbiomac.2022.03.087

13. Predictive modelling of powder compaction for binary mixtures using the finite element method

Author:
Dingeman L.H. van der Haven; Frederik H. Ørtoft; Kaisa Naelapää; Ioannis S. Fragkopoulos; James A. Elliott
Source:
Powder technology 2022 v.403 pp. 117381
ISSN:
0032-5910
Subject:
pharmaceutical industry,   etc   ; automation; calcium hydrogen phosphate; cellulose; drugs; finite element analysis; models; technology;     Show all 8 Subjects
Abstract:
... Despite the widespread use of solid-form drug delivery within the pharmaceutical industry, tablets remain challenging to formulate because their properties depend strongly on the powder composition and details of the compaction process. Powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, can be used to aid the des ...
DOI:
10.1016/j.powtec.2022.117381

14. An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications

Author:
Silvia Lomartire; Ana M. M. Gonçalves
Source:
Marine drugs 2022 v.20 no.2 pp. -
ISSN:
1660-3397
Subject:
pharmaceutical industry,   etc   ; Chlorophyta; Phaeophyceae; Rhodophyta; antioxidants; dietary supplements; drug development; human health; macroalgae; polysaccharides;     Show all 10 Subjects
Abstract:
... Nowadays, seaweeds are widely involved in biotechnological applications. Due to the variety of bioactive compounds in their composition, species of phylum Ochrophyta, class Phaeophyceae, phylum Rhodophyta and Chlorophyta are valuable for the food, cosmetic, pharmaceutical and nutraceutical industries. Seaweeds have been consumed as whole food since ancient times and used to treat several diseases, ...
DOI:
10.3390/md20020141

15. Biomonitoring parabens in dogs using fur sample analysis – Preliminary studies

Author:
Krystyna Makowska; Julia Martín; Andrzej Rychlik; Irene Aparicio; Juan Luis Santos; Esteban Alonso; Sławomir Gonkowski
Source:
Science of the total environment 2022 v.807 pp. 150757
ISSN:
0048-9697
Subject:
pharmaceutical industry,   etc   ; cosmetics; dogs; environment; environmental monitoring; fur; liquid chromatography; methylparaben; standard deviation; toxicology;     Show all 10 Subjects
Abstract:
... Parabens are widely used in the food, cosmetics and pharmaceutical industry and are widespread in the environment. As endocrine disruptors, parabens have adverse effects on living organisms. However, knowledge of the exposure of domestic animals to parabens is extremely scarce.Therefore, this study assessed the exposure level of dogs to three parabens commonly used in industry (i.e. methylparaben ...
DOI:
10.1016/j.scitotenv.2021.150757

16. Phenolic compounds from coffee by-products: Extraction and application in the food and pharmaceutical industries

Author:
Aline Felten Bondam; Daiele Diolinda da Silveira; Jaqueline Pozzada dos Santos; Jessica Fernanda Hoffmann
Source:
Trends in food science & technology 2022 v.123 pp. 172-186
ISSN:
0924-2244
Subject:
pharmaceutical industry,   etc   ; caffeine; chlorogenic acid; cosmetics; electric field; environmental impact; fermentation; flavonoids; ultrasonics; wastes;     Show all 10 Subjects
Abstract:
... Coffee by-products are generated along the coffee production chain, from harvest to brewing. The presence of phenolic compounds, caffeine, and flavonoids in coffee and its by-products has attracted attention with respect to their applications in foods and pharmaceutical matrices, especially considering the bioactive potential of these molecules. These by-products can be used as ingredients to redu ...
DOI:
10.1016/j.tifs.2022.03.013

17. Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties

Author:
Veronica M. Masila; Albert J. Ndakala; Jacob O. Midiwo; Robert Byamukama; Rahab W. Kamau; Mallika Kumarihamy; Ilias Muhammad
Source:
Natural product research 2022 v.36 no.9 pp. 2321-2328
ISSN:
1478-6427
Subject:
pharmaceutical industry,   etc   ; Cryptococcus neoformans; acetates; carvacrol; methicillin-resistant Staphylococcus aureus; monoterpenoids; research; spectral analysis;     Show all 8 Subjects
Abstract:
... Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzyloxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (2), 2-isopro ...
DOI:
10.1080/14786419.2020.1833201

18. Predicting drug-microbiome interactions with machine learning

Author:
Laura E. McCoubrey; Simon Gaisford; Mine Orlu; Abdul W. Basit
Source:
Biotechnology advances 2022 v.54 pp. 107797
ISSN:
0734-9750
Subject:
pharmaceutical industry,   etc   ; biotechnology; drugs; humans; intestinal microorganisms; medicine; microbiome; patient care; patients; physiological response; risk;     Show all 11 Subjects
Abstract:
... Pivotal work in recent years has cast light on the importance of the human microbiome in maintenance of health and physiological response to drugs. It is now clear that gastrointestinal microbiota have the metabolic power to promote, inactivate, or even toxify the efficacy of a drug to a level of clinically relevant significance. At the same time, it appears that drug intake has the propensity to ...
DOI:
10.1016/j.biotechadv.2021.107797

19. Amide and Peptide Couplings Mediated by Pivaloyl Mixed Anhydrides in Aqueous Media

Author:
Carolin Manske; Marco Schmiedtchen; Siebo Gellhaar; Michael Kiesel; Jochen Becker
Source:
ACS sustainable chemistry & engineering 2022 v.10 no.16 pp. 5307-5314
ISSN:
2168-0485
Subject:
pharmaceutical industry,   etc   ; amides; anhydrides; aqueous solutions; chlorides; green chemistry; moieties; peptides; research and development; surfactants; wastes;     Show all 11 Subjects
Abstract:
... From the wide range of different chemical transformations used in the pharmaceutical industry, amide and peptide couplings belong to the most important and widely applied. This is due to the relevance of the amide moiety in pharmaceutical compounds. Unfortunately, traditional amidation reaction conditions require hazardous reagents and organic solvents which generate significant amounts of waste. ...
DOI:
10.1021/acssuschemeng.2c00642

20. Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro

Author:
Morten Seirup; Srikumar Sengupta; Scott Swanson; Brian E. McIntosh; Mike Collins; Li-Fang Chu; Zhang Cheng; David U. Gorkin; Bret Duffin; Jennifer M. Bolin; Cara Argus; Ron Stewart; James A. Thomson
Source:
Genomics 2022 v.114 no.3 pp. 110330
ISSN:
0888-7543
Subject:
pharmaceutical industry,   etc   ; albumins; biochemical pathways; chromatin; drugs; gene expression; genes; genomics; hepatocytes; hepatotoxicity; liver; sequence analysis;     Show all 12 Subjects
Abstract:
... Primary hepatocytes are widely used in the pharmaceutical industry to screen drug candidates for hepatotoxicity, but hepatocytes quickly dedifferentiate and lose their mature metabolic function in culture. Attempts have been made to better recapitulate the in vivo liver environment in culture, but the full spectrum of signals required to maintain hepatocyte function ex vivo remains elusive. To elu ...
DOI:
10.1016/j.ygeno.2022.110330