PubAg

Main content area

You searched for: Subject "pharmaceutical industry" Remove constraint Subject: "pharmaceutical industry"
Start Over

Search

2,263  Search Results

« Previous | 1 - 20 of 2,263 |
Number of results to display per page

Search Results

1. Pervaporation: The emerging technique for extracting aroma compounds from food systems

Author:
Castro-Muñoz, Roberto
Source:
Journal of food engineering 2019 v.253 pp. 27-39
ISSN:
0260-8774
Subject:
pharmaceutical industry,   etc   ; odor compounds; pervaporation; solutes;     Show all 4 Subjects
Abstract:
... To date, according to the latest literature inputs, membrane-based technologies have demonstrated to meet the recovery of several high-added-value compounds from agro-food products. Particularly, Pervaporation (PV), as a highly selective membrane technique, has demonstrated its ability in separating specific solutes like aroma compounds, which represent a current research challenge for food, cosme ...
DOI:
10.1016/j.jfoodeng.2019.02.013

2. Research on pressure drop solution and pilot-scale application of bio-trickling filter for the treatment of butan-2-yl ethanoate

Author:
Zhang, Yun; Liu, Jia; Deng, Wei; Qin, Yiwei; Xing, Yi; Li, Jian
Source:
Process biochemistry 2019 v.79 pp. 118-126
ISSN:
1359-5113
Subject:
pharmaceutical industry,   etc   ; high-throughput nucleotide sequencing; microorganisms;     Show all 3 Subjects
Abstract:
... A pilot-scale bio-trickling filter (BTF) packed with ceramsite was investigated to treat butan-2-yl ethanoate (BE), which is discharged from the pharmaceutical industry. To choose an appropriate operation technology, the performance of twin bench-scale BTFs, vertical (BTF1) and horizontal (BTF2) towers, to purify BE were tested. The BTF1 had superior degradation capabilities when compared to BTF2, ...
DOI:
10.1016/j.procbio.2018.12.008

3. Modified Starches as Direct Compression Excipients – Effect of Physical and Chemical Modifications on Tablet Properties: A Review

Author:
Lawal, Mariam V.
Source:
DieStärke = 2019 v.71 no.1-2 pp. e1800040
ISSN:
0038-9056
Subject:
pharmaceutical industry,   etc   ; functional properties; modified starch; polymers;     Show all 4 Subjects
Abstract:
... Starch is an abundant natural polymer with unique properties that make it amenable to various kinds of treatments. This deliberate attempt at altering the character of native starch results in modified starches. Starches are extensively used in the pharmaceutical industry, especially as excipients in tablet formulation. It is now widely acknowledged that starches in their native form have function ...
DOI:
10.1002/star.201800040

4. TEMPORARY REMOVAL: Vibrational spectroscopy for the pharmaceutical industry: From benchtop to handheld innovative applications

Author:
Clavaud, Riccardo Deidda; Sacré, Pierre-Yves; Coic, Laureen; Avohou, Hermane; Hubert, Philippe; Ziemons, Eric
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
pharmaceutical industry,   etc   ; issues and policy; spectroscopy;     Show all 3 Subjects
Abstract:
... The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal ...
DOI:
10.1016/j.trac.2018.11.045

5. Introducing new reactions and technologies in industrial synthesis: Challenges, hurdles and opportunities for start-up initiatives for sustainable chemistry

Author:
Erdelmeier, Irene
Source:
Sustainable chemistry and pharmacy 2018 v.10 pp. 79-83
ISSN:
2352-5541
Subject:
pharmaceutical industry,   etc   ; electrochemistry; green chemistry;     Show all 3 Subjects
Abstract:
... Following up on the UNEP/UNIDO/ISC3-workshop in Berlin in September 2017, the context of the French start-up initiative INNOVERDA is presented, and its anticipated contribution to mainstreaming the practice of green and sustainable chemistry highlighted. INNOVERDA is dedicated to implement electrochemical flow methods for sustainable production processes in the chemical and pharmaceutical industry ...
DOI:
10.1016/j.scp.2018.09.006

6. Experimental and computational investigation of segregation during tumblers unloading

Author:
Volpato, S.; Scanferla, L.; Santomaso, A.C.
Source:
Powder technology 2018 v.338 pp. 538-547
ISSN:
0032-5910
Subject:
pharmaceutical industry,   etc   ; mixers; mixing; powders;     Show all 4 Subjects
Abstract:
... Dry mixing is a common operation in many industrial processes. The unloading of the mixer is an essential aspect of the process which actively contributes to the final quality of the mixture. Its effect however is often underestimate or even ignored. In the present work the consequences of the unloading process on mixture quality were investigated in three different types of tumbling mixers: a sym ...
DOI:
10.1016/j.powtec.2018.07.066

7. Capturing particle-particle interactions for cylindrical fibrous particles in different flow regimes

Author:
Farivar, Foad; Zhang, Hu; Tian, Zhao F.; Qi, Guo Q.; Lukas, Stefan
Source:
Powder technology 2018 v.330 pp. 418-424
ISSN:
0032-5910
Subject:
pharmaceutical industry,   etc   ; powders; terminal velocity;     Show all 3 Subjects
Abstract:
... Non-spherical particles are widely used in the chemical and pharmaceutical industries. Often these particles are over-simplified as equivalent spherical particles for calculation of drag forces and particle-particle interactions. We have developed a three-dimensional discrete element method (DEM) for rigid cylindrical fibrous particles with a high aspect ratio. In this method, a cylindrical partic ...
DOI:
10.1016/j.powtec.2018.02.050

8. Preparation of novel optimum liquisolid compacts via incorporating water granulation process to enhance the powder characterizations and dissolution behavior of a poorly soluble drug: Norfloxacin

Author:
Said Suliman, Ammar; Anderson, Rosaleen J.; Elkordy, Amal Ali
Source:
Powder technology 2019 v.354 pp. 259-270
ISSN:
0032-5910
Subject:
pharmaceutical industry,   etc   ; compressibility; drugs; liquids; models; norfloxacin; powders; thermography;     Show all 8 Subjects
Abstract:
... The aim of this work is to investigate the addition of wet granulation technique into liquisolid process in order to enhance the characterizations of liquisolid compacts, such as flowability, compressibility and the percentage of drug release (using norfloxacin as a model of poorly soluble-permeable drug) in neutral dissolution medium. The water in the liquisolid formulations works as a liquid bin ...
DOI:
10.1016/j.powtec.2019.05.071

9. RNAi therapeutic and its innovative biotechnological evolution

Author:
Weng, Yuhua; Xiao, Haihua; Zhang, Jinchao; Liang, Xing-Jie; Huang, Yuanyu
Source:
Biotechnology advances 2019 v.37 no.5 pp. 801-825
ISSN:
0734-9750
Subject:
pharmaceutical industry,   etc   ; RNA interference; adults; amyloidosis; drugs; nucleic acids; therapeutics;     Show all 7 Subjects
Abstract:
... Recently, United States Food and Drug Administration (FDA) and European Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic, ONPATTRO™ (Patisiran), for the treatment of the polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis in adults. This is the first RNAi therapeutic all over the world, as well as the first FDA-approved treatment for this in ...
DOI:
10.1016/j.biotechadv.2019.04.012

10. Therapeutic mRNA delivery to leukocytes

Author:
Granot-Matok, Yasmin; Kon, Edo; Dammes, Niels; Mechtinger, Gilad; Peer, Dan
Source:
Journal of controlled release 2019 v.305 pp. 165-175
ISSN:
0168-3659
Subject:
pharmaceutical industry,   etc   ; leukocytes; messenger RNA; new drugs; vaccination;     Show all 5 Subjects
Abstract:
... In the past few years mRNA molecules have become an attractive class of new drugs with numerous opportunities. mRNA therapeutics holds great potential for the treatment of a variety of diseases and is an emerging field both in academia and in the pharma industry. Among the various mRNA-based therapeutic approaches, immunotherapy is one of the pioneering and most advanced therapy to date. Immune ce ...
DOI:
10.1016/j.jconrel.2019.05.032

11. Effect of pulsed electric fields on the activity of food-grade papain in a continuous system

Author:
Meza-Jiménez, María de Lourdes; Pokhrel, Prashant-Raj; Robles de la Torre, Raúl René; Barbosa-Canovas, Gustavo V.; Hernández-Sánchez, Humberto
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2019 v.109 pp. 336-341
ISSN:
0023-6438
Subject:
pharmaceutical industry,   etc   ; electric field; foods; moieties; papain; pulsed electric fields;     Show all 6 Subjects
Abstract:
... Papain is an enzyme widely studied due to its multiple applications in foods, brewery, and the pharmaceutical industry, among others. Food-grade papain was treated with pulsed electric field technology to evaluate possible changes on its residual activity (RA), relative protein concentration (RPC), sulfhydryl group content, and structural changes. Three factors were evaluated: electric field (10 a ...
DOI:
10.1016/j.lwt.2019.04.037

12. Codon and Codon-Pair Usage Tables (CoCoPUTs): Facilitating Genetic Variation Analyses and Recombinant Gene Design

Author:
Alexaki, Aikaterini; Kames, Jacob; Holcomb, David D.; Athey, John; Santana-Quintero, Luis V.; Lam, Phuc Vihn Nguyen; Hamasaki-Katagiri, Nobuko; Osipova, Ekaterina; Simonyan, Vahan; Bar, Haim; Komar, Anton A.; Kimchi-Sarfaty, Chava
Source:
Journal of molecular biology 2019 v.431 no.13 pp. 2434-2441
ISSN:
0022-2836
Subject:
pharmaceutical industry,   etc   ; codons; databases; genetic variation; genomics; human diseases; statistics;     Show all 7 Subjects
Abstract:
... Usage of sequential codon-pairs is non-random and unique to each species. Codon-pair bias is related to but clearly distinct from individual codon usage bias. Codon-pair bias is thought to affect translational fidelity and efficiency and is presumed to be under the selective pressure. It was suggested that changes in codon-pair utilization may affect human disease more significantly than changes i ...
DOI:
10.1016/j.jmb.2019.04.021

13. Mild, Metal-Free Oxidative Ring-Expansion Approach for the Synthesis of Benzo[b]azepines

Author:
Stockerl, Sebastian; Danelzik, Tobias; Piekarski, Dariusz G.; García Mancheño, Olga
Source:
Organic letters 2019 v.21 no.12 pp. 4535-4539
ISSN:
1523-7052
Subject:
pharmaceutical industry,   etc   ; Lewis bases; azepines; catalysts; chemical reactions; chemical structure;     Show all 6 Subjects
Abstract:
... Benzo[b]azepines are important structural motifs for the pharmaceutical industry. However, their syntheses are usually lengthy, involving several steps, transition-metal catalysts, and/or harsh conditions. A novel, general, mild, and metal-free oxidative ring expansion tandem reaction of hydroquinolines with TMSCHN₂ as a versatile soft nucleophile to gain access to these valuable compounds in a si ...
DOI:
10.1021/acs.orglett.9b01433

14. Quantitation of low concentrations of polysorbates 80 in protein formulations by Coomassie brilliant blue

Author:
Cheng, Yongfeng; Liu, Yuling; Wei, Haiming; Sun, Rui; Tian, Zhigang; Zheng, Xiaodong
Source:
Analytical biochemistry 2019 v.573 pp. 67-72
ISSN:
0003-2697
Subject:
pharmaceutical industry,   etc   ; benzalkonium chloride; colorimetry; octoxynol; polysorbates; proteins; surfactants; viruses;     Show all 8 Subjects
Abstract:
... Polysorbate 80, as pharmaceutical excipient and virus inactivating agent, is commonly used in the protein pharmaceutical industry. In this study, a method has been developed for the determination of low concentration of Polysorbate 80 in the presence of high concentration proteins (≤100 mg/ml) and excipients. This colorimetric method is based on the interaction of Polysorbate 80 and Coomassie bril ...
DOI:
10.1016/j.ab.2019.03.001

15. 3D printed elastic mould granulation

Author:
Okeyo, Clint; Chowdhury, Dewan F.; Cheung, Karmen; Rahmanian, Nejat
Source:
Powder technology 2019 v.344 pp. 380-392
ISSN:
0032-5910
Subject:
pharmaceutical industry,   etc   ; coatings; drugs; drying; engineering; granules; powders; product development;     Show all 8 Subjects
Abstract:
... In the pharmaceutical industry, enhanced process understanding resulting in superior control of product attributes, has the potential to save up to 20% of process engineering and product development costs during drug development. With the aim of achieving enhanced process understating, a novel approach for granulation of fine powders is presented. First, a mould with the desired particle shape and ...
DOI:
10.1016/j.powtec.2018.12.009

16. Recent trends and future perspective of pharmaceutical wet granulation for better process understanding and product development

Author:
Thapa, Prakash; Tripathi, Julu; Jeong, Seong Hoon
Source:
Powder technology 2019 v.344 pp. 864-882
ISSN:
0032-5910
Subject:
pharmaceutical industry,   etc   ; granules; melting; models; powders; process design; product development;     Show all 7 Subjects
Abstract:
... Current trends in pharmaceutical wet granulation have been shifted from traditional approach to systematic and modern approaches, enabling the production of highly engineered product. In this context, quality by design (QbD), modelling, and simulation gradually become important tools in the pharmaceutical industry. In this review, several aspects of high-shear wet granulation (HSWG), such as proce ...
DOI:
10.1016/j.powtec.2018.12.080

17. Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis

Author:
Phelan, James P.; Lang, Simon B.; Sim, Jaehoon; Berritt, Simon; Peat, Andrew J.; Billings, Katelyn; Fan, Lijun; Molander, Gary A.
Source:
Journal of the American Chemical Society 2019 v.141 no.8 pp. 3723-3732
ISSN:
1520-5126
Subject:
pharmaceutical industry,   etc   ; alkylation; carbon; cross-coupling reactions; nickel; redox reactions;     Show all 6 Subjects
Abstract:
... DNA-encoded library (DEL) technology is a powerful tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomolecular targets. Success in this endeavor lies in sampling diverse chemical libraries. However, current DELs tend to be deficient in C(sp³) carbon counts. We report unique solutions to the challenge of increasing both the chemical diversity ...
DOI:
10.1021/jacs.9b00669

18. Water/Cosolvent Attraction Induced Phase Separation: A Molecular Picture of Cononsolvency

Author:
Zuo, Taisen; Ma, Changli; Jiao, Guisheng; Han, Zehua; Xiao, Shiyan; Liang, Haojun; Hong, Liang; Bowron, Daniel; Soper, Alan; Han, Charles C.; Cheng, He
Source:
Macromolecules 2019 v.52 no.2 pp. 457-464
ISSN:
1520-5835
Subject:
pharmaceutical industry,   etc   ; hydrogen bonding; neutrons; separation; solubility; solvents;     Show all 6 Subjects
Abstract:
... Cononsolvency is a phenomenon for which the solubility of a macromolecule decreases or even vanishes in the mixture of two good solvents. Although it has been widely applied in the physicochemical, green chemical, and pharmaceutical industries, its origin is still under active debate. Here, by using combined neutron total scattering, deuterium-labeling, and all-atom molecular dynamic simulations, ...
DOI:
10.1021/acs.macromol.8b02196

19. Living in the Fast Lane—High Throughput Controlled/Living Radical Polymerization

Author:
Oliver, Susan; Zhao, Lily; Gormley, Adam J.; Chapman, Robert; Boyer, Cyrille
Source:
Macromolecules 2018 v.52 no.1 pp. 3-23
ISSN:
1520-5835
Subject:
pharmaceutical industry,   etc   ; automation; drugs; oxygen; polymerization; polymers;     Show all 6 Subjects
Abstract:
... Combinatorial and high throughput (HTP) methodologies have long been used by the pharmaceutical industry to accelerate the rate of drug discovery. HTP techniques can also be applied in polymer chemistry to more efficiently elucidate structure–property relationships, to increase the speed of new material development, and to rapidly optimize polymerization conditions. Controlled living/radical polym ...
DOI:
10.1021/acs.macromol.8b01864

20. Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited

Author:
Bryan, Marian C.; DunnRetired., Peter J.; Entwistle, David; Gallou, Fabrice; Koenig, Stefan G.; Hayler, John D.; Hickey, Matthew R.; Hughes, Shaun; Kopach, Michael E.; Moine, Gerard; Richardson, Paul; Roschangar, Frank; Steven, Alan; Weiberth, Franz J.
Source:
Green chemistry 2018 v.20 no.22 pp. 5082-5103
ISSN:
1463-9270
Subject:
pharmaceutical industry,   etc   ; drugs; green chemistry; solvents;     Show all 4 Subjects
Abstract:
... In 2007 the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable assembled a list of key green chemistry research areas to both identify transformations that would benefit from improvements in process greenness and to encourage academic research to this end. The list provided the topics for a review of the literature, published in 2007 in the journal Green Chemistry. As part of ...
DOI:
10.1039/c8gc01276h