An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
pharmaceuticalindustry, etc ; cellulose; flavor; lubricants; Show all 4 Subjects
Abstract:
... Microcrystalline cellulose (MCC) is one of the most popular cellulose derivatives in the pharmaceutical industry. Thanks to its outstanding tabletability, MCC is generally included in direct compression (DC) tablet formulations containing poor-tabletability active pharmaceutical ingredients. Nowadays, numerous grades of MCC from various brands are accessible for pharmaceutical manufacturers, leadi ...
pharmaceuticalindustry, etc ; catalysts; hydrogenation; lactones; Show all 4 Subjects
Abstract:
... A highly efficient Ni-catalyzed asymmetric hydrogenation of aromatic γ- and δ-ketoacids has been developed, affording a series of γ- and δ-aryl lactones in high yields and excellent enantioselectivities (≤98% ee). The hydrogenation could occur smoothly on a gram scale with 0.05 mol % catalyst loading (S/C = 2000). This protocol provides an efficient and practical approach for accessing chiral lact ...
pharmaceuticalindustry, etc ; lithium batteries; polymers; solar cells; Show all 4 Subjects
Abstract:
... Polymer coatings find use in a wide range of industrial applications, from conventional paints and coatings in building and construction to the pharmaceutical industry, organic solar cell production, and lithium battery technology. Despite their importance, there are gaps in our understanding of the drying process, the stress development during drying, and their influence on the final mechanical p ...
pharmaceuticalindustry, etc ; biosensors; biosynthesis; biotechnology; heterologous gene expression; secondary metabolites; Show all 6 Subjects
Abstract:
... Natural products derived from bacterial secondary metabolites contribute greatly to the pharmaceutical industry. Heterologous expression of natural product biosynthetic pathways can remarkably improve the yield of target products and lead to the discovery of numerous derivatives. Therefore, high-throughput analytical methods are urgently needed for the detection of natural products. Biosensors all ...
pharmaceuticalindustry, etc ; dietary supplements; food composition; lactic acid; probiotics; therapeutics; Show all 6 Subjects
Abstract:
... Today, the use of microorganisms to produce substances that can be consumable, used as a food ingredient and have a positive effect on consumer health is attracting attention and studies in this field are increasing. Besides, the therapeutic products produced by lactic acid bacteria (LAB) can be used in the food and pharmaceutical industry to create desirable characteristics of foods. In addition ...
pharmaceuticalindustry, etc ; cost effectiveness; food composition; health promotion; naringenin; pepper; India; Show all 7 Subjects
Abstract:
... In this study, a method based on QuEChERS method miniaturization followed by UHPLC-MS/MS analysis was used for the first time to determine phenolic acids and flavonoids in red pepper (Capsicum spp.). Under the optimized extraction and analysis conditions, fourteen phenolic compounds in eleven varieties of red pepper belonging to four domesticated species, C. baccatum L., C. chinense Jacq., C. frut ...
pharmaceuticalindustry, etc ; absorbance; fluorescence; ionic strength; pH; physical chemistry; stoichiometry; temperature; Show all 8 Subjects
Abstract:
... The combination of supramolecular chemistry and aggregation-induced emission-based luminogens (AIEgens) has recently attracted tremendous attention because of its ability to offer large emission enhancement even in substantially dilute solutions. In this work, a new aggregation-induced emission (AIE)-based supramolecular assembly has been reported, which consists of a polyanionic cyclodextrin deri ...
pharmaceuticalindustry, etc ; catalytic activity; cross-coupling reactions; magnetism; nanocatalysts; palladium; polymers; solubility; Show all 8 Subjects
Abstract:
... The recyclable nanomagnetic Pd-complex PAMAM G₀-Pd@γ-Fe₂O₃ is reported for catalytic C–C cross-coupling reactions of challenging substrates. Mainly, a great variety of aryl chlorides can be used as substrates for Suzuki–Miyaura and Mizoroki–Heck reactions under mild reaction conditions (60–90 °C) and low catalyst loading (<1 mol% Pd) in aqueous media. The presence of numerous polar groups in the p ...
pharmaceuticalindustry, etc ; carbon; carbon dioxide; energy; issues and policy; leadership; longevity; China; Show all 8 Subjects
Abstract:
... With China's aspiration of building a healthy nation and increasing its average life expectancy, the pharmaceutical industry will continue to grow in the coming years. Considering the high energy consumption and emissions in the pharmaceutical industry, striving for sustainability will be essential to achieving the 2030 target of peaking CO₂ emissions and becoming carbon neutral by 2060. This pape ...
pharmaceuticalindustry, etc ; Labrenzia; Paederus; aquatic bacteria; biosynthesis; endosymbionts; fermentation; genes; polyketides; toxins; Show all 10 Subjects
Abstract:
... Pederin is a potent polyketide toxin that causes severe skin lesions in humans after contact with insects of genus Paederus. Due to its potent anticancer activities, pederin family compounds have raised the interest of pharmaceutical industry. Despite the extensive studies on the cluster of biosynthetic genes responsible for the production of pederin, it has not yet been possible to isolate and cu ...
pharmaceuticalindustry, etc ; Bacillus subtilis; benzylpenicillin; catalysts; pH; photocatalysis; photolysis; pollutants; sodium; toxicity; Show all 10 Subjects
Abstract:
... The photocatalytic degradation of pharmaceutical micropollutants of Penicillin G (PG) was investigated in a photoreactor at a laboratory scale. The impact of type of catalyst, pH, and initial concentration of PG were studied. Maximum removal efficiency was obtained at pH = 6.8, [ZnO]₀ = 0.8 g L⁻¹, and [PG]₀ = 5 mg L⁻¹ and reaction time of 150 min. The addition of persulfate sodium (PPS) enhanced t ...
pharmaceuticalindustry, etc ; Vibrio cholerae; biosynthesis; encapsulation; interleukin-10; interleukin-6; lipopolysaccharides; pH; selenium; Show all 9 Subjects
Abstract:
... The lipopolysaccharide (LPS) of Vibrio cholerae plays a significant role in stimulating primary protection and immune responses. LPS delivery has been limited by the stimulation of inflammatory cytokines. This work aimed to report the synthesis and performance of this formulation in modulating immune responses and protecting LPS against acidic gastric medium. Alg-Cs-LPS-SeNPs composite was fabrica ...
pharmaceuticalindustry, etc ; automation; calcium hydrogen phosphate; cellulose; drugs; finite element analysis; models; technology; Show all 8 Subjects
Abstract:
... Despite the widespread use of solid-form drug delivery within the pharmaceutical industry, tablets remain challenging to formulate because their properties depend strongly on the powder composition and details of the compaction process. Powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, can be used to aid the des ...
pharmaceuticalindustry, etc ; Chlorophyta; Phaeophyceae; Rhodophyta; antioxidants; dietary supplements; drug development; human health; macroalgae; polysaccharides; Show all 10 Subjects
Abstract:
... Nowadays, seaweeds are widely involved in biotechnological applications. Due to the variety of bioactive compounds in their composition, species of phylum Ochrophyta, class Phaeophyceae, phylum Rhodophyta and Chlorophyta are valuable for the food, cosmetic, pharmaceutical and nutraceutical industries. Seaweeds have been consumed as whole food since ancient times and used to treat several diseases, ...
pharmaceuticalindustry, etc ; cosmetics; dogs; environment; environmental monitoring; fur; liquid chromatography; methylparaben; standard deviation; toxicology; Show all 10 Subjects
Abstract:
... Parabens are widely used in the food, cosmetics and pharmaceutical industry and are widespread in the environment. As endocrine disruptors, parabens have adverse effects on living organisms. However, knowledge of the exposure of domestic animals to parabens is extremely scarce.Therefore, this study assessed the exposure level of dogs to three parabens commonly used in industry (i.e. methylparaben ...
pharmaceuticalindustry, etc ; caffeine; chlorogenic acid; cosmetics; electric field; environmental impact; fermentation; flavonoids; ultrasonics; wastes; Show all 10 Subjects
Abstract:
... Coffee by-products are generated along the coffee production chain, from harvest to brewing. The presence of phenolic compounds, caffeine, and flavonoids in coffee and its by-products has attracted attention with respect to their applications in foods and pharmaceutical matrices, especially considering the bioactive potential of these molecules. These by-products can be used as ingredients to redu ...
pharmaceuticalindustry, etc ; Cryptococcus neoformans; acetates; carvacrol; methicillin-resistant Staphylococcus aureus; monoterpenoids; research; spectral analysis; Show all 8 Subjects
Abstract:
... Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzyloxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (2), 2-isopro ...
pharmaceuticalindustry, etc ; biotechnology; drugs; humans; intestinal microorganisms; medicine; microbiome; patient care; patients; physiological response; risk; Show all 11 Subjects
Abstract:
... Pivotal work in recent years has cast light on the importance of the human microbiome in maintenance of health and physiological response to drugs. It is now clear that gastrointestinal microbiota have the metabolic power to promote, inactivate, or even toxify the efficacy of a drug to a level of clinically relevant significance. At the same time, it appears that drug intake has the propensity to ...
pharmaceuticalindustry, etc ; amides; anhydrides; aqueous solutions; chlorides; green chemistry; moieties; peptides; research and development; surfactants; wastes; Show all 11 Subjects
Abstract:
... From the wide range of different chemical transformations used in the pharmaceutical industry, amide and peptide couplings belong to the most important and widely applied. This is due to the relevance of the amide moiety in pharmaceutical compounds. Unfortunately, traditional amidation reaction conditions require hazardous reagents and organic solvents which generate significant amounts of waste. ...
Morten Seirup; Srikumar Sengupta; Scott Swanson; Brian E. McIntosh; Mike Collins; Li-Fang Chu; Zhang Cheng; David U. Gorkin; Bret Duffin; Jennifer M. Bolin; Cara Argus; Ron Stewart; James A. Thomson
... Primary hepatocytes are widely used in the pharmaceutical industry to screen drug candidates for hepatotoxicity, but hepatocytes quickly dedifferentiate and lose their mature metabolic function in culture. Attempts have been made to better recapitulate the in vivo liver environment in culture, but the full spectrum of signals required to maintain hepatocyte function ex vivo remains elusive. To elu ...