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1. Design and analysis of bridging studies with prior probabilities on the null and alternative hypotheses

Author:
Zeng, Donglin; Pan, Zhiying; Lin, D. Y.
Source:
Biometrics 2020 v.76 no.1 pp. 224-234
ISSN:
0006-341X
Subject:
pharmaceutical industry,   etc   ; biometry; drugs;     Show all 3 Subjects
Abstract:
... The pharmaceutical industry and regulatory agencies are increasingly interested in conducting bridging studies in order to bring an approved drug product from the original region (eg, United States or European Union) to a new region (eg, Asian‐Pacific countries). In this article, we provide a new methodology for the design and analysis of bridging studies by assuming prior knowledge on how the nul ...
DOI:
10.1111/biom.13175

2. Multienzymatic Nanoassemblies: Recent Progress and Applications

Author:
Giannakopoulou, Archontoula; Gkantzou, Elena; Polydera, Angeliki; Stamatis, Haralambos
Source:
Trends in biotechnology 2020 v.38 no.2 pp. 202-216
ISSN:
0167-7799
Subject:
pharmaceutical industry,   etc   ; biocatalysts; biopolymers; catalytic activity; drugs;     Show all 5 Subjects
Abstract:
... Biotechnological research has turned to multienzymatic nanoassemblies as a promising concept to host multiple applications. Here, we consider important aspects around the development and optimization of such biocatalytic systems and present current advances in utilizing bi- and multienzymatic cascade reactions in diverse fields, including ultrasensitive biosensing, development of pharmaceuticals, ...
DOI:
10.1016/j.tibtech.2019.07.010

3. Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water

Author:
Petkova, Desislava; Borlinghaus, Niginia; Sharma, Sudripet; Kaschel, Johannes; Lindner, Tanja; Klee, Johanna; Jolit, Anais; Haller, Vanessa; Heitz, Stephanie; Britze, Katarina; Dietrich, Justin; Braje, Wilfried M.; Handa, Sachin
Source:
ACS sustainable chemistry & engineering 2020 v.8 no.33 pp. 12612-12617
ISSN:
2168-0485
Subject:
pharmaceutical industry,   etc   ; amination; cellulose; hydrophobicity; laboratory experimentation; nanocatalysts;     Show all 6 Subjects
Abstract:
... Although greener and faster access to fine chemicals and APIs is highly desirable, there are currently no synthetic methodologies which undergo reaction completions within a few seconds to minutes in water under benchtop laboratory conditions. Here, we report a methodology that allows the instantaneous formation of ligated ultrasmall Pd nanoparticles in the hydrophobic pockets of benign cellulose ...
DOI:
10.1021/acssuschemeng.0c03975

4. Extraction of bioactive compounds from purple corn using emerging technologies: A review

Author:
Cristianini, Marcelo; Guillén Sánchez, Jhoseline Stayce
Source:
Journal of food science 2020 v.85 no.4 pp. 862-869
ISSN:
0022-1147
Subject:
pharmaceutical industry,   etc   ; bioactive compounds; corn; food industry; functional properties; technology;     Show all 6 Subjects
Abstract:
... The increase in the use of bioactive compounds from purple corn in the food and pharmaceutical industries has led to the investigation of nonconventional extraction technologies that allow one to obtain more of these compounds. In this context, nonconventional techniques, known as emerging technologies, use more efficient processes that are safe for the environment, in addition to obtaining produc ...
DOI:
10.1111/1750-3841.15074

5. Hybrid Mechanistic-Empirical Approach to the Modeling of Twin Screw Feeders for Continuous Tablet Manufacturing

Author:
Bascone, Davide; Galvanin, Federico; Shah, Nilay; Garcia-Munoz, Salvador
Source:
Industrial & engineering chemistry process design and development 2020 v.59 no.14 pp. 6650-6661
ISSN:
1520-5045
Subject:
pharmaceutical industry,   etc   ; equipment; manufacturing; models; powders; prediction; process design; screws;     Show all 8 Subjects
Abstract:
... Nowadays, screw feeders are popular equipment in the pharmaceutical industry. However, despite the increasing research in the last decade in the manufacturing of powder-based products, there is still a lack of knowledge on the physics governing the dynamic behavior of these systems. As a result, data-driven models have often been used to address process design, optimization, and control applicatio ...
DOI:
10.1021/acs.iecr.0c00420

6. Green or nongreen innovation? Different strategic preferences among subsidized enterprises with different ownership types

Author:
Liu, Zimeng; Li, Xu; Peng, Xuerong; Lee, Seoki
Source:
Journal of cleaner production 2020 v.245 pp. 118786
ISSN:
0959-6526
Subject:
pharmaceutical industry,   etc   ; business enterprises; public ownership; subsidies; sustainable technology; China;     Show all 6 Subjects
Abstract:
... Governments often turn to subsidies to boost enterprises’ innovation activities, which gives subsidized enterprises room for allocating the subsidies among different innovation activities. Taking insights from institutional logic theory, this paper proposes that enterprises exhibit different subsidy-allocation behaviors between nongreen and green innovations and that the positive effect of subsidi ...
DOI:
10.1016/j.jclepro.2019.118786

7. Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents

Author:
Enmark, Martin; Bagge, Joakim; Samuelsson, Jörgen; Thunberg, Linda; Örnskov, Eivor; Leek, Hanna; Limé, Fredrik; Fornstedt, Torgny
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.2 pp. 299-309
ISSN:
1618-2642
Subject:
pharmaceutical industry,   etc   ; diastereomers; drug development; drugs; oligonucleotides; triethylamine;     Show all 6 Subjects
Abstract:
... Oligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related impurities, making efficient separation systems for purification and analysis a key challenge during pharmaceutical drug development. To increase the fundamental understanding of the important preparative separation step, mass-overloaded injections of a ...
DOI:
10.1007/s00216-019-02236-9
PubMed:
31814048
PubMed Central:
PMC6992550

8. Renaissance of Allostery to Disrupt Protein Kinase Interactions

Author:
Leroux, Alejandro E.; Biondi, Ricardo M.
Source:
Trends in biochemical sciences 2020 v.45 no.1 pp. 27-41
ISSN:
0968-0004
Subject:
pharmaceutical industry,   etc   ; binding sites; learning; protein kinases; protein-protein interactions;     Show all 5 Subjects
Abstract:
... Protein–protein interactions often regulate the activity of protein kinases by allosterically modulating the conformation of the ATP-binding site. Bidirectional allostery implies that reverse modulation (i.e., from the ATP-binding site to the interaction and regulatory sites) must also be possible. Here, we review both the allosteric regulation of protein kinases and recent work describing how com ...
DOI:
10.1016/j.tibs.2019.09.007

9. Stabilizing properties of fucoidan for the alumina suspension containing the cationic surfactant

Author:
Matusiak, Jakub; Grządka, Elżbieta; Bastrzyk, Anna
Source:
Carbohydrate polymers 2020 v.245 pp. 116523
ISSN:
0144-8617
Subject:
pharmaceutical industry,   etc   ; adsorption; aluminum oxide; cationic surfactants; cetyltrimethylammonium bromide; colloids; fucoidan; pH; stabilizers; surface tension; tensiometers;     Show all 11 Subjects
Abstract:
... The paper presents the influence of fucoidan (FD) on stability of alumina suspensions in the presence of cationic surfactant hexadecyltrimethylammonium bromide (CTAB). The research results show that fucoidan adsorbs on the alumina surface and that the adsorption decreases in the CTAB presence. This is due to formation of the polymer-surfactant complexes characterized by lower affinity for the alum ...
DOI:
10.1016/j.carbpol.2020.116523

10. Current state of aromatics production using yeast: achievements and challenges

Author:
Liu, Quanli; Liu, Yi; Chen, Yun; Nielsen, Jens
Source:
Current opinion in biotechnology 2020 v.65 pp. 65-74
ISSN:
0958-1669
Subject:
pharmaceutical industry,   etc   ; Saccharomyces cerevisiae; aromatic compounds; biosynthesis; feedstocks; markets; metabolic engineering; models; shikimate pathway; yeasts;     Show all 10 Subjects
Abstract:
... Aromatics find a range of applications in the chemical, food, cosmetic and pharmaceutical industries. While production of aromatics on the current market heavily relies on petroleum-derived chemical processes or direct extraction from plants, there is an increasing demand for establishing new renewable and sustainable sources of aromatics. To this end, microbial cell factories-mediated bioproducti ...
DOI:
10.1016/j.copbio.2020.01.008

11. Biochemical characterization and degradation pattern analysis of a novel PL-6 alginate lyase from Streptomyces coelicolor A3(2)

Author:
Cheng, Danyang; Liu, Zhen; Jiang, Chengcheng; Li, Laihao; Xue, Changhu; Mao, Xiangzhao
Source:
Food chemistry 2020 v.323 pp. 126852
ISSN:
0308-8146
Subject:
pharmaceutical industry,   etc   ; Phaeophyceae; Streptomyces coelicolor; alginate lyase; alginates; biomass; glycosidic linkages; pH; polymerization; trisaccharides;     Show all 10 Subjects
Abstract:
... Alginate is the main component of brown algae which contributes to a huge biomass. The alginate oligosaccharides (AOs) have been widely used in food, cosmetic and pharmaceutical industries due to their various physiological activities. In this study, we expressed and characterized a novel PL-6 alginate lyase, named OUC-ScCD6. The results indicated that OUC-ScCD6 showed highest activity at 50 °C an ...
DOI:
10.1016/j.foodchem.2020.126852

12. Engineering the Plant Secretory Pathway for the Production of Next-Generation Pharmaceuticals

Author:
Margolin, Emmanuel A.; Strasser, Richard; Chapman, Ros; Williamson, Anna-Lise; Rybicki, Edward P.; Meyers, Ann E.
Source:
Trends in biotechnology 2020 v.38 no.9 pp. 1034-1044
ISSN:
0167-7799
Subject:
pharmaceutical industry,   etc   ; biopharmaceuticals; biosynthesis; molecular farming; plant proteins; post-translational modification; recombinant proteins;     Show all 7 Subjects
Abstract:
... Production of biologics in plants, or plant molecular pharming, is a promising protein expression technology that is receiving increasing attention from the pharmaceutical industry. Previously, low expression yields of recombinant proteins and the realization that certain post-translational modifications (PTMs) may not occur optimally limited the widespread acceptance of the technology. However, m ...
DOI:
10.1016/j.tibtech.2020.03.004

13. Spray-coated graphene oxide hollow fibers for nanofiltration

Author:
Mahalingam, Dinesh K.; Falca, Gheorghe; Upadhya, Lakshmeesha; Abou-Hamad, Edy; Batra, Nitinkumar; Wang, Shaofei; Musteata, Valentina; da Costa, Pedro M.; Nunes, Suzana P.
Source:
Journal of membrane science 2020 v.606 pp. 118006
ISSN:
0376-7388
Subject:
pharmaceutical industry,   etc   ; acetone; adhesion; artificial membranes; crosslinking; dispersions; graphene oxide; nanofiltration; nuclear magnetic resonance spectroscopy; solvents;     Show all 10 Subjects
Abstract:
... Advances in process intensification in the chemical and pharmaceutical industry depends on the availability of more sustainable separation methods. For this progress, membranes with high stability in organic solvents are needed. GO-coated membranes could be advantageous in these applications, being chemically, thermally and mechanically stable. However, simple, scalable, low-cost fabrication metho ...
DOI:
10.1016/j.memsci.2020.118006

14. Novel gel-like Pickering emulsions stabilized solely by hydrophobic starch nanocrystals

Author:
Chang, Siqiao; Chen, Xu; Liu, Shuwen; Wang, Chan
Source:
International journal of biological macromolecules 2020 v.152 pp. 703-708
ISSN:
0141-8130
Subject:
pharmaceutical industry,   etc   ; anhydrides; emulsifying; emulsions; food industry; hydrophobicity; light microscopy; microstructure; nanocrystals; oils; stabilizers; starch;     Show all 12 Subjects
Abstract:
... The development of gel-like Pickering emulsions stabilized by edible particles has attracted significant interest in the food colloid field. This work reported that starch nanocrystals (SNCs), modified by octenyl succinic anhydride (OSA), could introduced as a natural stabilizer for gel-like Pickering emulsions. The formation, microstructure and stability of Pickering emulsions were characterized ...
DOI:
10.1016/j.ijbiomac.2020.02.175

15. Turbostratic nanoporous carbon sheet membrane for ultrafast and selective nanofiltration in viscous green solvents

Author:
Jang, Jaedong; Nam, Yoon Tae; Kim, Daeok; Kim, Yong-Jae; Kim, Dae Woo; Jung, Hee-Tae
Source:
Journal of materials chemistry A 2020 v.8 no.17 pp. 8292-8299
ISSN:
2050-7496
Subject:
pharmaceutical industry,   etc   ; carbon; graphene oxide; heat treatment; isopropyl alcohol; molecular weight; nanofiltration; nanopores; polymers; solutes; solvents;     Show all 11 Subjects
Abstract:
... Development of ultrafast and selective nanofiltration membranes for viscous green solvents, such as isopropyl alcohol (IPA), is a big challenge in the chemical, food, and pharmaceutical industries. However, all existing nanofiltration membranes, including polymers, have been critically limited by low solvent permeance and low selectivity for solute molecules with a nanoscale feature dimension. Thi ...
DOI:
10.1039/d0ta00804d

16. Genetic Control of Glandular Trichome Development

Author:
Chalvin, Camille; Drevensek, Stéphanie; Dron, Michel; Bendahmane, Abdelhafid; Boualem, Adnane
Source:
Trends in plant science 2020 v.25 no.5 pp. 477-487
ISSN:
1360-1385
Subject:
pharmaceutical industry,   etc   ; Artemisia annua; flavor; genes; metabolites; models; morphogenesis; odors; plant adaptation; tomatoes; transcription factors; trichomes;     Show all 12 Subjects
Abstract:
... Plant glandular trichomes are epidermal secretory structures producing various specialized metabolites. These metabolites are involved in plant adaptation to its environment and many of them have remarkable properties exploited by fragrance, flavor, and pharmaceutical industries. The identification of genes controlling glandular trichome development is of high interest to understand how plants pro ...
DOI:
10.1016/j.tplants.2019.12.025

17. Longitudinal distribution of lapachol in the stalk of ipê species (Handroanthus spp.)

Author:
de Souza, Josefa Magna Alves; de Tarso Barbosa Sampaio, Paulo; Degterev, Igor Anatolievich; Santos, Alcides Loureiro; dos Santos, Vinicius Silva
Source:
European journal of wood and wood products 2020 v.78 no.3 pp. 609-611
ISSN:
0018-3768
Subject:
pharmaceutical industry,   etc   ; Handroanthus capitatus; Handroanthus impetiginosus; Handroanthus ochraceus; Handroanthus serratifolius; bioactive properties; naphthoquinones;     Show all 7 Subjects
Abstract:
... Lapachol is a natural naphthoquinone with several significant biological activities. This study aims to analyze the longitudinal distribution of lapachol in four species of Handroanthus spp. The Handroanthus serratifolius (Vahl.) S. O. Grose and Handroanthus impetiginosus (Mart. Ex DC.) Mattos species showed higher yields of lapachol than Handroanthus ochraceus (Cham.) Mattos and the Handroanthus ...
DOI:
10.1007/s00107-020-01530-z

18. Diterpenes and their derivatives as promising agents against dengue virus and dengue vectors: A literature‐based review

Author:
Islam, Muhammad Torequl; Mubarak, Mohammad S.
Source:
Phytotherapy research 2020 v.34 no.4 pp. 674-684
ISSN:
0951-418X
Subject:
pharmaceutical industry,   etc   ; Aedes aegypti; Aedes albopictus; Dengue virus; bioactive properties; databases; dengue; diterpenoids; therapeutics;     Show all 9 Subjects
Abstract:
... Dengue, a mosquito‐borne viral disease, causes about 100 million cases of infection annually. It is a major public concern, and if left untreated or improperly diagnosed, may cause serious health problems or even death. Historically, dengue has not considered priorities for pharmaceutical companies made the available treatment options. Therefore, medicinal scientists are revealing new insights and ...
DOI:
10.1002/ptr.6562

19. Microbial and enzymatic strategies for the production of L-ribose

Author:
Chen, Ming; Wu, Hao; Zhang, Wenli; Mu, Wanmeng
Source:
Applied microbiology and biotechnology 2020 v.104 no.8 pp. 3321-3329
ISSN:
0175-7598
Subject:
pharmaceutical industry,   etc   ; antiviral agents; biotransformation; catalytic activity; enzymatic treatment; isomerases; pentoses; purification methods; synthesis;     Show all 9 Subjects
Abstract:
... L-Ribose is a non-naturally occurring pentose that recently has become known for its potential application in the pharmaceutical industry, as it is an ideal starting material for use in synthesizing L-nucleosides analogues, an important class of antiviral drugs. In the past few decades, the synthesis of L-ribose has been mainly undertaken through the chemical route. However, chemical synthesis of ...
DOI:
10.1007/s00253-020-10471-9

20. Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review

Author:
Santos, Soraya Silva; de Araújo, Renan Vinicius; Giarolla, Jeanine; Seoud, Omar El; Ferreira, Elizabeth Igne
Source:
International journal of antimicrobial agents 2020 v.55 no.4 pp. 105906
ISSN:
0924-8579
Subject:
pharmaceutical industry,   etc   ; Chagas disease; anti-infective agents; drug therapy; drugs; leishmaniasis; schistosomiasis;     Show all 7 Subjects
Abstract:
... Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are a considerable global challenge. Despite the huge number of people infected, NDs do not create interest from pharmaceutical companies because the associated revenue is generally low. Most of the research on these diseases has been conducted in academic institutions. The chemotherapeutic armamentarium for NDs is ...
DOI:
10.1016/j.ijantimicag.2020.105906