PubAg

Main content area

You searched for: Subject "phenotype" Remove constraint Subject: "phenotype"
Start Over

Search

37,620  Search Results

« Previous | 1 - 20 of 37,620 |
Number of results to display per page

Search Results

1. Evaluation of the chitin-binding dye Congo red as a selection agent for the isolation, classification, and enumeration of ascomycete yeasts

Author:
Linder, Tomas
Source:
Archives of microbiology 2018 v.200 no.4 pp. 671-675
ISSN:
0302-8933
Subject:
phenotype,   etc   ; Ascomycota; dyes; yeasts;     Show all 4 Subjects
Abstract:
... Thirty-nine strains of ascomycete yeasts representing 35 species and 33 genera were tested for their ability to grow on solid agar medium containing increasing concentrations of the chitin-binding dye Congo red. Six strains were classified as hypersensitive (weak or no growth at 10 mg/l Congo red), five were moderately sensitive (weak or no growth at 50 mg/l), three were moderately tolerant (weak ...
DOI:
10.1007/s00203-018-1498-y

2. The emerging roles for the chromatin structure regulators CTCF and cohesin in neurodevelopment and behavior

Author:
Davis, Liron; Onn, Itay; Elliott, Evan
Source:
Cellular and molecular life sciences 2018 v.75 no.7 pp. 1205-1214
ISSN:
1420-682X
Subject:
phenotype,   etc   ; chromatin; humans; neurodevelopment;     Show all 4 Subjects
Abstract:
... Recent genetic and technological advances have determined a role for chromatin structure in neurodevelopment. In particular, compounding evidence has established roles for CTCF and cohesin, two elements that are central in the establishment of chromatin structure, in proper neurodevelopment and in regulation of behavior. Genetic aberrations in CTCF, and in subunits of the cohesin complex, have bee ...
DOI:
10.1007/s00018-017-2706-7

3. Controlling and exploiting cell-to-cell variation in metabolic engineering

Author:
Wang, Tiebin; Dunlop, Mary J
Source:
Current opinion in biotechnology 2019 v.57 pp. 10-16
ISSN:
0958-1669
Subject:
phenotype,   etc   ; biosynthesis; gene expression; genetic variation; metabolic engineering;     Show all 5 Subjects
Abstract:
... Individual cells within a population can display diverse phenotypes due to differences in their local environment, genetic variation, and stochastic expression of genes. Understanding this cell-to-cell variation is important for metabolic engineering applications because variability can impact production. For instance, recent studies have shown that production can be highly heterogeneous among eng ...
DOI:
10.1016/j.copbio.2018.08.013

4. The effects of cardiomyopathy-associated mutations in the head-to-tail overlap junction of α-tropomyosin on its properties and interaction with actin

Author:
Matyushenko, Alexander M.; Koubassova, Natalia A.; Shchepkin, Daniil V.; Kopylova, Galina V.; Nabiev, Salavat R.; Nikitina, Larisa V.; Bershitsky, Sergey Y.; Levitsky, Dmitrii I.; Tsaturyan, Andrey K.
Source:
International journal of biological macromolecules 2019 v.125 pp. 1266-1274
ISSN:
0141-8130
Subject:
phenotype,   etc   ; actin; cardiomyopathy; muscle contraction; muscles; point mutation; sarcomeres; tropomyosins;     Show all 8 Subjects
Abstract:
... Tropomyosin (Tpm) plays a crucial role in the regulation of muscle contraction by controlling actin-myosin interaction. Tpm coiled-coil molecules bind each other via overlap junctions of their N- and C-termini and form a semi-rigid strand that binds the helical surface of an actin filament. The high bending stiffness of the strand is essential for high cooperativity of muscle regulation. Point mut ...
DOI:
10.1016/j.ijbiomac.2018.09.105

5. Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development

Author:
Nakayama, Waka; Fujiwara, Yukio; Kosuge, Yasuhiro; Monthakantirat, Orawan; Fujikawa, Kazumi; Watthana, Santi; Kitanaka, Susumu; Makino, Toshiaki; Ishiuchi, Kan’ichiro
Source:
Phytochemistry letters 2019 v.29 pp. 98-103
ISSN:
1874-3900
Subject:
phenotype,   etc   ; Lycopodium alkaloids; humans; interleukin-10; macrophages; neoplasms; spectral analysis;     Show all 7 Subjects
Abstract:
... Two new Lycopodium alkaloids, phlenumdines D (1) and E (2), have been isolated from the club moss Phlegmariurus nummulariifolius (Blume) Ching along with ten known compounds (3−12), and the structures were elucidated by spectroscopic analyses. The absolute configurations of 1 and 2 were established by chemical conversion and modified Mosher’s method, respectively. Phlenumdines E (2), A (8), huperm ...
DOI:
10.1016/j.phytol.2018.11.010

6. On the contribution of mass spectrometry-based platforms to the field of personalized oncology

Author:
Orlando, Eleonora; Aebersold, Ruedi
Source:
Trends in analytical chemistry 2019 v.110 pp. 129-142
ISSN:
0165-9936
Subject:
phenotype,   etc   ; genomics; mass spectrometry; neoplasms; patients; proteome; proteomics;     Show all 7 Subjects
Abstract:
... Over the last decades, the increasing technical ability to generate extensive molecular profiles of cancer patient cohorts was accompanied by the notion that anticancer strategies could be tailored to the individual patient, thus giving rise to personalized approaches. Implicit in this development is the need to establish informative molecular profiles to guide clinical decisions. Although at pres ...
DOI:
10.1016/j.trac.2018.10.018

7. Raven food calls indicate sender’s age and sex

Author:
Boeckle, Markus; Szipl, Georgine; Bugnyar, Thomas
Source:
Frontiers in zoology 2018 v.15 no.1 pp. 5
ISSN:
1742-9994
Subject:
phenotype,   etc   ; acoustic properties; animals; vocalization;     Show all 4 Subjects
Abstract:
... BACKGROUND: Acoustic parameters of animal signals have been shown to correlate with various phenotypic characteristics of the sender. These acoustic characteristics can be learned and categorized and thus are a basis for perceivers’ recognition abilities. One of the most demanding capacities is individual recognition, achievable only after repeated interactions with the same individual. Still, cla ...
DOI:
10.1186/s12983-018-0255-z

8. Pheno‐Deep Counter: a unified and versatile deep learning architecture for leaf counting

Author:
Giuffrida, Mario Valerio; Doerner, Peter; Tsaftaris, Sotirios A.
Source:
Theplant journal 2018 v.96 no.4 pp. 880-890
ISSN:
0960-7412
Subject:
phenotype,   etc   ; computer software; leaves; prediction;     Show all 4 Subjects
Abstract:
... Direct observation of morphological plant traits is tedious and a bottleneck for high‐throughput phenotyping. Hence, interest in image‐based analysis is increasing, with the requirement for software that can reliably extract plant traits, such as leaf count, preferably across a variety of species and growth conditions. However, current leaf counting methods do not work across species or conditions ...
DOI:
10.1111/tpj.14064

9. Complexity-aware simple modeling

Author:
Gómez-Schiavon, Mariana; El-Samad, Hana
Source:
Current opinion in microbiology 2018 v.45 pp. 47-52
ISSN:
1369-5274
Subject:
phenotype,   etc   ; insulating materials; mathematical models;     Show all 3 Subjects
Abstract:
... Mathematical models continue to be essential for deepening our understanding of biology. On one extreme, simple or small-scale models help delineate general biological principles. However, the parsimony of detail in these models as well as their assumption of modularity and insulation make them inaccurate for describing quantitative features. On the other extreme, large-scale and detailed models c ...
DOI:
10.1016/j.mib.2018.01.004

10. Low Phosphate Puts Auxin in the Root Hairs

Author:
Parry, Geraint
Source:
Trends in plant science 2018 v.23 no.10 pp. 845-847
ISSN:
1360-1385
Subject:
phenotype,   etc   ; auxins; phosphates; root hairs;     Show all 4 Subjects
Abstract:
... The molecular changes that allow plant roots to response to low phosphate levels are poorly understood. A series of three papers investigate this phenomenon and reveal which components of the auxin response are key for transmitting the phosphate signal into changes in root hair phenotypes. ...
DOI:
10.1016/j.tplants.2018.07.009

11. Author Correction: Double trisomy (XXX+21 karyotype) in a six-year-old girl with down phenotype

Author:
Vergara-Mendez, LauraDaniela; Talero-Gutiérrez, Claudia; Velez-Van-Meerbeke, Alberto
Source:
Journal of genetics 2018 v.97 no.2 pp. 585
ISSN:
0022-1333
Subject:
phenotype,   etc   ; girls; karyotyping; patients; trisomics;     Show all 5 Subjects
Abstract:
... In both the abstract and introduction, the karyotype of a patient with double trisomy is described as ‘47, XXX, +21’, where it should read as ‘48, XXX, +21’. ...
DOI:
10.1007/s12041-018-0952-6

12. Indicators of transitions in biological systems

Author:
Clements, Christopher F.; Ozgul, Arpat
Source:
Ecology letters 2018 v.21 no.6 pp. 905-919
ISSN:
1461-023X
Subject:
phenotype,   etc   ; autocorrelation; biodiversity; models; prediction;     Show all 5 Subjects
Abstract:
... In the face of global biodiversity declines, predicting the fate of biological systems is a key goal in ecology. One popular approach is the search for early warning signals (EWSs) based on alternative stable states theory. In this review, we cover the theory behind nonlinearity in dynamic systems and techniques to detect the loss of resilience that can indicate state transitions. We describe the ...
DOI:
10.1111/ele.12948

13. Viable but non‐culturable and persistence describe the same bacterial stress state

Author:
Kim, Jun‐Seob; Chowdhury, Nityananda; Yamasaki, Ryota; Wood, Thomas K.
Source:
Environmental microbiology 2018 v.20 no.6 pp. 2038-2048
ISSN:
1462-2912
Subject:
phenotype,   etc   ; Escherichia coli; bacteria; cytosol;     Show all 4 Subjects
Abstract:
... Bacteria are often thought of as having two dormant phenotypes: the viable but non‐culturable (VBNC) state and the persister state. Here we investigate the relatedness of the two stress‐induced phenotypes at the single‐cell level and examine cell morphology and quantify cell resuscitation. Using the classic starvation conditions to create VBNC cells, we found that the majority of the remaining Esc ...
DOI:
10.1111/1462-2920.14075

14. Task-driven active sensing framework applied to leaf probing

Author:
Foix, Sergi; Alenyà, Guillem; Torras, Carme
Source:
Computers and electronics in agriculture 2018 v.147 pp. 166-175
ISSN:
0168-1699
Subject:
phenotype,   etc   ; grid maps; leaves; methodology;     Show all 4 Subjects
Abstract:
... This article presents a new method for actively exploring a 3D workspace with the aim of localizing relevant regions for a given task. Our method encodes the exploration route in a multi-layer occupancy grid map. This map, together with a multiple-view estimator and a maximum-information-gain gathering approach, incrementally provide a better understanding of the scene until reaching the task term ...
DOI:
10.1016/j.compag.2018.01.020

15. Assessment of tissue-specific multifactor effects in environmental –omics studies of heterogeneous biological samples: Combining hyperspectral image information and chemometrics

Author:
Olmos, Víctor; Marro, Mónica; Loza-Alvarez, Pablo; Raldúa, Demetrio; Prats, Eva; Piña, Benjamí; Tauler, Romà; de Juan, Anna
Source:
Talanta 2019 v.194 pp. 390-398
ISSN:
0039-9140
Subject:
phenotype,   etc   ; Danio rerio; chemometrics; exposure duration; eyes; hyperspectral imagery; larvae; least squares; melanin; models;     Show all 10 Subjects
Abstract:
... The use of hyperspectral imaging techniques in biological studies has increased in the recent years. Hyperspectral images (HSI) provide chemical information and preserve the morphology and original structure of heterogeneous biological samples, which can be potentially useful in environmental –omics studies when effects due to several factors, e.g., contaminant exposure, phenotype,…, at a specific ...
DOI:
10.1016/j.talanta.2018.10.029

16. Reconsidering the classification of sweet taste liker phenotypes: A methodological review

Author:
Iatridi, Vasiliki; Hayes, John E.; Yeomans, Martin R.
Source:
Food quality and preference 2019 v.72 pp. 56-76
ISSN:
0950-3293
Subject:
phenotype,   etc   ; alcohols; behavior disorders; food intake; hedonic scales; obesity; protocols; sensory evaluation; sucrose; sweetness; taste;     Show all 11 Subjects
Abstract:
... Human ingestive behavior depends on myriad factors, including both sensory and non-sensory determinants. Of the sensory determinants, sweet taste is a powerful stimulus and liking for sweetness is widely accepted as an innate human trait. However, the universality of sweet-liking has been challenged. Sub-groups exhibiting strong liking (sweet likers) or having aversive responses to sweet taste (sw ...
DOI:
10.1016/j.foodqual.2018.09.001

17. Exposure of Candida parapsilosis complex to agricultural azoles: An overview of the role of environmental determinants for the development of resistance

Author:
Brilhante, Raimunda Sâmia Nogueira; Alencar, Lucas Pereira de; Bandeira, Silviane Praciano; Sales, Jamille Alencar; Evangelista, Antônio José de Jesus; Serpa, Rosana; Cordeiro, Rossana de Aguiar; Pereira-Neto, Waldemiro de Aquino; Sidrim, José Júlio Costa; Castelo-Branco, Débora de Souza Collares Maia; Rocha, Marcos Fábio Gadelha
Source:
The Science of the total environment 2019 v.650 pp. 1231-1238
ISSN:
0048-9697
Subject:
phenotype,   etc   ; Candida parapsilosis; biofilm; cryptic species; fluconazole; gene expression; minimum inhibitory concentration; tebuconazole; tetraconazole;     Show all 9 Subjects
Abstract:
... This work investigated the phenotypic behavior of Candida parapsilosis species complex in response to exposure to agricultural azoles and fluconazole. Three fluconazole-susceptible strains of C. parapsilosis sensu stricto, C. orthopsilosis and C. metapsilosis were used. Initial minimum inhibitory concentrations (iMICs) for agricultural and clinical azoles were determined by broth microdilution. Th ...
DOI:
10.1016/j.scitotenv.2018.09.096

18. Emerging neurotechnology for antinoceptive mechanisms and therapeutics discovery

Author:
Black, Bryan J.; Atmaramani, Rahul; Plagens, Sarah; Campbell, Zachary T.; Dussor, Gregory; Price, Theodore J.; Pancrazio, Joseph J.
Source:
Biosensors & bioelectronics 2019 v.126 pp. 679-689
ISSN:
0956-5663
Subject:
phenotype,   etc   ; biosensors; electrophysiology; microfluidic technology; models; narcotics; pain; screening; sensory neurons; therapeutics;     Show all 10 Subjects
Abstract:
... The tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative therapeutics. Phenotypic screening provides a complementary approach to traditional target-based drug discovery. Profiling cellular phenotypes enables quantification of physiologically relevant traits central to a disease pathology without prior identif ...
DOI:
10.1016/j.bios.2018.11.015

19. Analytical epigenetics: single-molecule optical detection of DNA and histone modifications

Author:
Heck, Christian; Michaeli, Yael; Bald, Ilko; Ebenstein, Yuval
Source:
Current opinion in biotechnology 2019 v.55 pp. 151-158
ISSN:
0958-1669
Subject:
phenotype,   etc   ; DNA; RNA; diagnostic techniques; epigenetics; gene expression; genomics; genotype; histones; nucleotide sequences; physicochemical properties;     Show all 11 Subjects
Abstract:
... The field of epigenetics describes the relationship between genotype and phenotype, by regulating gene expression without changing the canonical base sequence of DNA. It deals with molecular genomic information that is encoded by a rich repertoire of chemical modifications and molecular interactions. This regulation involves DNA, RNA and proteins that are enzymatically tagged with small molecular ...
DOI:
10.1016/j.copbio.2018.09.006

20. Strategies for directed and adapted evolution as part of microbial strain engineering

Author:
Zhou, Shenghu; Alper, Hal S
Source:
Journal of chemical technology and biotechnology 2019 v.94 no.2 pp. 366-376
ISSN:
0268-2575
Subject:
phenotype,   etc   ; engineering; enzymes; evolution; genetic variation; microorganisms; mutagenesis; screening; sequence diversity;     Show all 9 Subjects
Abstract:
... The industrial production of chemicals by microorganisms usually requires improvements to the enzymes, pathways, and strain that go beyond the capacity of innate enzymes. To achieve these phenotypes and overcome our limited capacity to de novo design these parts, directed and adaptive evolutionary approaches are used to explore new functions. This review highlights the recent advances in both sequ ...
DOI:
10.1002/jctb.5746