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1. Transport of lipopolysaccharides and phospholipids to the outer membrane

Author:
Wilson, Andrew; Ruiz, Natividad
Source:
Current opinion in microbiology 2021 v.60 pp. 51-57
ISSN:
1369-5274
Subject:
phospholipids,   etc   ; lipopolysaccharides; toxicity;     Show all 3 Subjects
Abstract:
... Cells must build and maintain at least one membrane that surrounds essential cellular components and provides structural integrity. Gram-negative bacteria possess an inner membrane, which separates the aqueous cytoplasmic and periplasmic compartments, and an outer membrane, which surrounds the periplasm. The outer membrane is an asymmetric bilayer with phospholipids in its inner leaflet and lipopo ...
DOI:
10.1016/j.mib.2021.01.006

2. Composition of Fatty Acids in Lipids and Volatile Compounds from Primula capitellata

Author:
Asilbekova, D. T.; Bobakulov, Kh. M.; Ozek, G.; Ozek, T.; Sagdullaev, Sh. Sh.
Source:
Chemistry of natural compounds 2021 v.57 no.3 pp. 416-419
ISSN:
0009-3130
Subject:
phospholipids,   etc   ; Primula; glycolipids; oleic acid;     Show all 4 Subjects
Abstract:
... Lipids from seeds, leaves, and roots of Primula capitellata Boiss. (Primulaceae) were studied for the first time. The composition of volatile compounds and the fatty-acid composition of neutral lipids, glycolipids, and phospholipids from leaves were established. γ-Linolenic and stearidonic acids and oleic acid methyl ester were identified. ...
DOI:
10.1007/s10600-021-03377-z

3. Lipocalin-1 is the acceptor protein for phospholipid transfer protein in tears

Author:
Glasgow, Ben J.; Abduragimov, Adil R.
Source:
Biochemical and biophysical research communications 2021 v.548 pp. 35-38
ISSN:
0006-291X
Subject:
phospholipids,   etc   ; fluorescence; humans; micelles; research;     Show all 5 Subjects
Abstract:
... Phospholipid transfer protein, ∼80 kDa, transfers phospholipids from micelles to lipid binding proteins. The acceptor protein in plasma is apolipoprotein-A1, 28 kDa. Previously, phospholipid transfer protein was found in tears but an acceptor protein was not identified. To search for the acceptor protein(s) in tears a fluorescent phospholipid transfer assay was altered to omit the extrinsic accept ...
DOI:
10.1016/j.bbrc.2021.02.054

4. The Groovy TMEM16 Family: Molecular Mechanisms of Lipid Scrambling and Ion Conduction

Author:
Kalienkova, Valeria; Clerico Mosina, Vanessa; Paulino, Cristina
Source:
Journal of molecular biology 2021 v.433 no.16 pp. 166941
ISSN:
0022-2836
Subject:
phospholipids,   etc   ; calcium; evolution; molecular biology; permeability;     Show all 5 Subjects
Abstract:
... The TMEM16 family of membrane proteins displays a remarkable functional dichotomy – while some family members function as Ca²⁺-activated anion channels, the majority of characterized TMEM16 homologs are Ca²⁺-activated lipid scramblases, which catalyze the exchange of phospholipids between the two membrane leaflets. Furthermore, some TMEM16 scramblases can also function as channels. Due to their in ...
DOI:
10.1016/j.jmb.2021.166941

5. Molecular dynamics simulation for mechanism revelation of the safety and nutrition of lipids and derivatives in food: State of the art

Author:
Nian, Binbin; Xu, Yong-Jiang; Liu, Yuanfa
Source:
Food research international 2021 v.145 pp. 110399
ISSN:
0963-9969
Subject:
phospholipids,   etc   ; food research; molecular dynamics; nutrition;     Show all 4 Subjects
Abstract:
... Molecular dynamics (MD) simulation has proved to be a powerful tool in the study of proteins, nucleic acids, lipids, and carbohydrates et al. in fields of health, nutrition, and food science. In particular, MD simulation has been employed in the investigation of various lipid systems such as triglycerides, phospholipid membranes, etc. Due to the continuous updating of computing resources and the d ...
DOI:
10.1016/j.foodres.2021.110399

6. Hydrophobe Containing Polypeptoids Complex with Lipids and Induce Fusogenesis of Lipid Vesicles

Author:
Omarova, Marzhana; Zhang, Yueheng; Mkam Tsengam, Igor Kevin; He, Jibao; Yu, Tianyi; Zhang, Donghui; John, Vijay
Source:
TheJournal of physical chemistry 2021 v.125 no.12 pp. 3145-3152
ISSN:
1520-5207
Subject:
phospholipids,   etc   ; aqueous solutions; drugs; hydrophobicity; organelles; peptides;     Show all 6 Subjects
Abstract:
... The hydrophobic effect of alkyl group insertion into phospholipid bilayers is exploited in modifying and modulating vesicle structure. We show that amphiphilic polypeptoids (peptide mimics) with n-decyl side chains, which we term as hydrophobe-containing polypeptoids (HCPs), can insert the alkyl hydrophobes into the membrane bilayer of phospholipid-based vesicles. Such insertion leads to disruptio ...
DOI:
10.1021/acs.jpcb.0c11477

7. Adsorption Kinetics of Oppositely Charged Hard and Soft Nanoparticles with Phospholipid Membranes

Author:
Bekir, Marek; Hörmann, Anja; Brückner, Christoph; Hoffmann, Ingo; Prévost, Sylvain; Gradzielski, Michael
Source:
Langmuir 2021 v.37 no.8 pp. 2800-2809
ISSN:
1520-5827
Subject:
phospholipids,   etc   ; adsorption; electrostatic interactions; nanomedicine; polymers;     Show all 5 Subjects
Abstract:
... Nanoparticles (NPs) have great potential for biological applications as typically they exhibit strongly size-dependent properties. Specifically, the interaction of NPs with phospholipid membranes is significantly relevant to nanomedicine and the related field of nanotoxicology. Therefore, the investigation of interactions of NPs with model membranes is not only fundamentally important but also pra ...
DOI:
10.1021/acs.langmuir.0c03553

8. Are endoplasmic reticulum subdomains shaped by asymmetric distribution of phospholipids? Evidence from a C. elegans model system

Author:
Cao, Zhe; Wang, Xiaowei; Huang, Xuhui; Mak, Ho Yi
Source:
BioEssays 2021 v.43 no.1 pp. e2000199
ISSN:
0265-9247
Subject:
phospholipids,   etc   ; biogenesis; cages; endoplasmic reticulum; homeostasis;     Show all 5 Subjects
Abstract:
... Physical contact between organelles are widespread, in part to facilitate the shuttling of protein and lipid cargoes for cellular homeostasis. How do protein‐protein and protein‐lipid interactions shape organelle subdomains that constitute contact sites? The endoplasmic reticulum (ER) forms extensive contacts with multiple organelles, including lipid droplets (LDs) that are central to cellular fat ...
DOI:
10.1002/bies.202000199

9. Evaporation retardation by model tear-lipid films: The roles of film aging, compositions and interfacial rheological properties

Author:
Svitova, Tatyana F.; Lin, Meng C.
Source:
Colloids and surfaces 2021 v.197 pp. 111392
ISSN:
0927-7765
Subject:
phospholipids,   etc   ; evaporation; humans; humidity; nanosheets; rheology; temperature;     Show all 7 Subjects
Abstract:
... A novel methodology for assessing evaporation (up to 48 h) through lipid-nanofilms in vitro was developed. The influence of lipid-mixture compositions on evaporation rates was studied. The evaporative fluxes and rheology of lipid-nanofilms were compared with those of human tear-lipid nanofilms in vitro.A sessile-drop technique with precise drop-volume control was adapted to measure evaporation rat ...
DOI:
10.1016/j.colsurfb.2020.111392

10. Liposomal/Nanoliposomal Encapsulation of Food-Relevant Enzymes and Their Application in the Food Industry

Author:
Mohammadi, Adeleh; Jafari, Seid Mahdi; Mahoonak, Alireza Sadeghi; Ghorbani, Mohammad
Source:
Food and bioprocess technology 2021 v.14 no.1 pp. 23-38
ISSN:
1935-5130
Subject:
phospholipids,   etc   ; bioprocessing; catalytic activity; encapsulation; food industry;     Show all 5 Subjects
Abstract:
... A liposomal vesicular structure is composed of one or more phospholipid bilayers in an aqueous environment. Liposomes are the most popular carriers used to design a delivery system for different compounds in the pharmacological, biochemical, biological, food, and agricultural sectors. Enzymes are commonly used ingredients in food industries, such as bakery, dairy, and beverages. Nevertheless, they ...
DOI:
10.1007/s11947-020-02513-x

11. One-step separation system of bio-functional lipid compounds from natural sources

Author:
Tsoupras, Alexandros; Pappas, Katherine M.; Sotiroudis, Theodore G.; Demopoulos, Constantinos A.
Source:
MethodsX 2021 v.8 pp. 101380
ISSN:
2215-0161
Subject:
phospholipids,   etc   ; animals; dietary supplements; fractionation; glycolipids; triacylglycerols;     Show all 6 Subjects
Abstract:
... Lipids are a very heterogeneous class of biomolecules with distinct structures and functions. Total lipids (TLs) obtained from natural sources are regularly further separated into lipid subclasses, with the two major ones being the polar lipids (PLs) and neutral lipids (NLs). Traditional analytical methods for fractionating TLs into NLs, PLs, and their subclasses, usually comprise difficult, costl ...
DOI:
10.1016/j.mex.2021.101380

12. The roles and applications of chaotropes and kosmotropes in industrial fermentation processes

Author:
Timson, David J.
Source:
World journal of microbiology & biotechnology 2020 v.36 no.6 pp. 89
ISSN:
0959-3993
Subject:
phospholipids,   etc   ; biotechnology; fermentation;     Show all 3 Subjects
Abstract:
... Chaotropicity has long been recognised as a property of some compounds. Chaotropes tend to disrupt non-covalent interactions in biological macromolecules (e.g. proteins and nucleic acids) and supramolecular assemblies (e.g. phospholipid membranes). This results in the destabilisation and unfolding of these macromolecules and assemblies. Unsurprisingly, these compounds are typically harmful to livi ...
DOI:
10.1007/s11274-020-02865-8

13. Platelet activating-factor acetylhydrolase II: A member of phospholipase A2 family that hydrolyzes oxidized phospholipids

Author:
Dong, Linyue; Li, Yiming; Wu, Huali
Source:
Chemistry and physics of lipids 2021 v.239 pp. 105103
ISSN:
0009-3084
Subject:
phospholipids,   etc   ; ischemia; oxidative stress; phospholipase A2; physics; substrate specificity;     Show all 6 Subjects
Abstract:
... Intracellular platelet activating-factor acetylhydrolase type II (PAF-AH II) is a 40-kDa monomeric enzyme. It was originally identified as an enzyme that hydrolyzes the acetyl group of PAF (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine). As a member of phospholipase A2 super family, PAF-AH II has broad substrate specificity. It can hydrolyze phospholipids with relatively short-length or oxidative ...
DOI:
10.1016/j.chemphyslip.2021.105103

14. Gating-related Structural Dynamics of the MgtE Magnesium Channel in Membrane-Mimetics Utilizing Site-Directed Tryptophan Fluorescence

Author:
Chatterjee, Satyaki; Brahma, Rupasree; Raghuraman, H.
Source:
Journal of molecular biology 2021 v.433 no.17 pp. 166691
ISSN:
0022-2836
Subject:
phospholipids,   etc   ; cations; detergents; fluorescence; homeostasis; magnesium; micelles; molecular biology; tryptophan;     Show all 9 Subjects
Abstract:
... Magnesium is the most abundant divalent cation present in the cell, and an abnormal Mg²⁺ homeostasis is associated with several diseases in humans. However, among ion channels, the mechanisms of intracellular regulation and transport of Mg²⁺ are poorly understood. MgtE is a homodimeric Mg²⁺-selective channel and is negatively regulated by high intracellular Mg²⁺ concentration where the cytoplasmic ...
DOI:
10.1016/j.jmb.2020.10.025

15. Photoresponsive supramolecular strategy for controlled assembly in light-inert double-chain surfactant system

Author:
Wang, Xuejiao; Gao, Xuedong; Xiao, Xiao; Jiang, Shasha; Yan, Yun; Huang, Jianbin
Source:
Journal of colloid and interface science 2021 v.594 pp. 727-736
ISSN:
0021-9797
Subject:
phospholipids,   etc   ; drugs; irradiation; materials science; medicine; photoisomerization; surfactants;     Show all 7 Subjects
Abstract:
... One of the main advances in double-chain surfactant systems has been their progress from the construction of assemblies to the transformation application in medicine and material science, especially to the drug delivery systems. Thus, it is critical to develop stimuli-responsive assemblies based on double-chain surfactants. We predicted that reversible assembly switching can be achieved by manipul ...
DOI:
10.1016/j.jcis.2021.02.084

16. Brevibacterium renqingii sp. nov., isolated from the Daqu of Baijiu

Author:
Yan, Yi; Xing, Xuan; Sun, Zhanbin; Li, Jia; Hao, Shuyue; Xu, Jialiang
Source:
Archives of microbiology 2021 v.203 no.5 pp. 2291-2296
ISSN:
0302-8933
Subject:
phospholipids,   etc   ; Brevibacterium epidermidis; genes; menaquinones; microbiology; monophyly; nucleotide sequences; China;     Show all 8 Subjects
Abstract:
... Two bacterial strains, designated REN4ᵀ and REN4-1, were isolated from daqu sample collected from baijiu factory located in Shanxi, China. The two strains shared highly similar 16S rRNA gene sequences (99.67% identities) and formed a monophyletic clade within the Brevibacterium 16S rRNA gene tree, showing 97.56–97.85% 16S rRNA gene sequence identities with type strains Brevibacterium permense VKM ...
DOI:
10.1007/s00203-021-02212-x

17. Facile fabrication of phospholipid-functionalized nanofiber-based barriers with enhanced anti-adhesion efficiency

Author:
Mao, Ying; Guidoin, Robert; Brochu, Gaëtan; Li, Yan; Zhang, Ze; Wang, Fujun; Wang, Lu
Source:
Colloids and surfaces 2021 v.203 pp. 111728
ISSN:
0927-7765
Subject:
phospholipids,   etc   ; adhesion; cell adhesion; fibroblasts; hydrophilicity; macrophages; nanofibers; porosity; wettability;     Show all 9 Subjects
Abstract:
... Electrospun nanofibrous membranes (NFMs) have attracted considerable attention as a potential physical barrier for reducing postoperative adhesion. However, no anti-adhesion barrier can completely prevent adhesion formation. In this study, phospholipid-functionalized NFMs were readily fabricated by one-step electrospinning to obtain nanofiber-based barriers with enhanced wettability and anti-adhes ...
DOI:
10.1016/j.colsurfb.2021.111728

18. First quantitative assessment of the adsorption of a fluorocarbon gas on phospholipid monolayers at the air/water interface

Author:
Liu, Xianhe; Counil, Claire; Shi, Da; Mendoza-Ortega, Estefania E.; Vela-Gonzalez, Andrea V.; Maestro, Armando; Campbell, Richard A.; Krafft, Marie Pierre
Source:
Journal of colloid and interface science 2021 v.593 pp. 1-10
ISSN:
0021-9797
Subject:
phospholipids,   etc   ; adsorption; air; liquids; microbubbles; perfluorocarbons; quantitative analysis; reflectometry;     Show all 8 Subjects
Abstract:
... Fluorocarbon gases introduced above monolayers of phospholipids at the air/water interface were recently found to promote the adsorption of diverse molecular compounds, with potential application in drug-loaded microbubble design. Quantitative determination of the fluorocarbon present in the monolayers is strongly needed for the development of such applications. We hypothesized that neutron reflec ...
DOI:
10.1016/j.jcis.2021.02.073

19. Selective association of desmin intermediate filaments with a phospholipid layer in droplets

Author:
Murakami, Keigo; Sato, Masashi; Miyasaka, Yoshiya; Hatori, Kuniyuki
Source:
Biochemical and biophysical research communications 2021 v.555 pp. 109-114
ISSN:
0006-291X
Subject:
phospholipids,   etc   ; desmin; fluorescent labeling; muscles; research; salt concentration;     Show all 6 Subjects
Abstract:
... Desmin, an intermediate filament protein expressed in muscle cells, plays a key role in the integrity and regulation of the contractile system. Furthermore, the distribution of desmin in cells and its interplay with plasma and organelle membranes are crucial for cell functions; however, the fundamental properties of lipid-desmin interactions remain unknown. Using a water-in-oil method for a limite ...
DOI:
10.1016/j.bbrc.2021.03.131

20. Structural and Biophysical Properties of Supercharged and Circularized Nanodiscs

Author:
Johansen, Nicolai Tidemand; Luchini, Alessandra; Tidemand, Frederik Grønbæk; Orioli, Simone; Martel, Anne; Porcar, Lionel; Arleth, Lise; Pedersen, Martin Cramer
Source:
Langmuir 2021 v.37 no.22 pp. 6681-6690
ISSN:
1520-5827
Subject:
phospholipids,   etc   ; lipid bilayers; neutrons; small-angle X-ray scattering;     Show all 4 Subjects
Abstract:
... Nanodiscs based on membrane scaffold proteins (MSPs) and phospholipids are used as membrane mimics to stabilize membrane proteins in solution for structural and functional studies. Combining small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), and time-resolved small-angle neutron scattering (TR-SANS), we characterized the structure and lipid bilayer properties of five dif ...
DOI:
10.1021/acs.langmuir.1c00560