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phospholipids, etc ; endocytosis; inositols; ion channels; microscopy; plasma membrane; reflectometry; second messengers; Show all 8 Subjects
Abstract:
... Inositol phospholipids are well known to form clusters in the cytoplasmic leaflet of the plasma membrane that are responsible for the interaction and recruitment of proteins involved in key biological processes like endocytosis, ion channel activation and secondary messenger production. Although their phosphorylated inositol ring headgroup plays an important role in protein binding, its orientatio ...
phospholipids, etc ; Oncorhynchus tshawytscha; astaxanthin; cholesterol; fermentation; food chemistry; lutein; nutritive value; pH; salmon; water activity; Show all 11 Subjects
Abstract:
... A jeotgal-like product was processed from Chinook salmon (Oncorrhynchus tshawytscha) roe. Physicochemical, biochemical, and microbiological compositions were studied during 30 days of fermentation. Fermentation decreased water activity (aw) and pH value. Total bacterial and LAB counts (log CFU/g) increased up to 12 days of processing and then no further changes occurred. Saturated fatty acids (SFA ...
phospholipids, etc ; Pampus argenteus; Thunnus obesus; diacylglycerols; food composition; marine fish; mass spectrometry; palmitoleic acid; sardines; seafoods; ultra-performance liquid chromatography; Show all 11 Subjects
Abstract:
... Palmitoleic acid (POA) is a monounsaturated n-7 fatty acid (16:1 n-7) that is active in modulating cardiovascular and metabolic processes. POA-structured phospholipids, diglycerides, and triglycerides (POA-PL, -DG, -TG) are abundantly present in marine life. In this study, POA and POA-lipids contained in crude lipids in visceral by-products of six seafood products (n = 6 for each sample) were anal ...
phospholipids, etc ; Pleuronectes platessa; cholesterol; fatty acid composition; food chemistry; lipid content; polychlorinated biphenyls; protein content; proximate composition; risk; seasonal variation; toxicity; triacylglycerols; Norway; Show all 14 Subjects
Abstract:
... The seasonal effect on chemical composition and contaminants in European plaice (Pleuronectes platessa) captured in Norwegian waters was investigated in three seasons (September, December, April). Fillets were compared by analysing proximate composition, lipid and protein profile, including fatty acids, lipid class distribution, free and total amino acids. Trace elements and polychlorinated biphen ...
... A better understanding of how plants adjust their flowering under unfavourable environmental conditions is key to developing climate-resilient crops. Recently, Susila et al. demonstrated that phospholipids controlling the transport of florigen (FLOWERING LOCUS T; FT) act as an additional layer to prevent flowering under unfavourable conditions. ...
Anvesh K. R. Dasari; Lucas Dillard; Sujung Yi; Elizabeth Viverette; Alimohammad Hojjatian; Urmi Sengupta; Rakez Kayed; Kenneth A. Taylor; Mario Juan Borgnia; Kwang Hun Lim
phospholipids, etc ; dementia; transmission electron microscopy; Show all 3 Subjects
Abstract:
... Accumulation of filamentous aggregates of α-synuclein is a pathological hallmark of several neurodegenerative diseases, including Parkinson’s disease (PD). The interaction between α-synuclein and phospholipids has been shown to play a critical role in the aggregation of α-synuclein. Most structural studies have, however, been focused on α-synuclein filaments formed in the absence of lipids. Here, ...
phospholipids, etc ; adhesion; drugs; graphene; molecular dynamics; Show all 5 Subjects
Abstract:
... Phospholipids are an important class of lipids that are widely used as model platforms for the study of biological processes and interactions. These lipids can form stable interfaces with solid substrates, such as graphene, and these interfaces have potential applications in biosensing and targeted drug delivery. In this paper, we perform molecular dynamics simulations of graphene-supported lipid ...
phospholipids, etc ; Gibbs free energy; biocompatibility; chitosan; cyclosporine; Show all 5 Subjects
Abstract:
... The Langmuir technique allows for the characterization of monolayers of biological and/or biologically active compounds which have high potential for application in tissue engineering to improve the implants biocompatibility. This group of substances includes 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), cyclosporine A (CsA), lauryl gallate (LG), and chitosan (Ch). The single (DOPC, CsA, LG), b ...
phospholipids, etc ; biopolymers; chitosan; electrolytes; neutrons; pH; surfactants; Show all 7 Subjects
Abstract:
... Membrane undulations are known to strongly affect the stability of uni- and multilamellar vesicles formed by surfactants or phospholipids. Herein, based on the same arguments, we hypothesise that the properties of polyelectrolyte mediated surfactant multilamellar vesicles, in particular the multiplicity – i.e. the number of layers forming the vesicle – depend on the dynamics of the membrane. Small ...
phospholipids, etc ; ethanol; lipid composition; nanocarriers; particle size; Show all 5 Subjects
Abstract:
... Our study investigated the manufacturing of lipid-based nanotherapeutics with stealth properties for siRNA delivery by employing a diffusion-driven microfluidic process in one or two-steps strategies to produce siRNA-loaded lipid nanocarriers and lipoplexes, respectively. In the one-step synthesis, siRNA in the aqueous phase is introduced from one inlet, while phospholipids dispersed in anhydrous ...
phospholipids, etc ; plasma membrane; polyproteins; virion; virus assembly; Show all 5 Subjects
Abstract:
... HIV-1 viral particle assembly occurs specifically at the plasma membrane and is driven primarily by the viral polyprotein Gag. Selective association of Gag with the plasma membrane is a key step in the viral assembly pathway, which is traditionally attributed to the MA domain. MA regulates specific plasma membrane binding through two primary mechanisms including: (1) specific interaction of the MA ...
phospholipids, etc ; biogenesis; cytoskeleton; droplets; endoplasmic reticulum; hydrophobicity; sterols; Show all 7 Subjects
Abstract:
... Lipid droplets (LDs) are ubiquitous, neutral lipid storage organelles that act as hubs of metabolic processes. LDs are structurally unique with a hydrophobic core that mainly consists of neutral lipids, sterol esters, and triglycerides, enclosed within a phospholipid monolayer. Nascent LD formation begins with the accumulation of neutral lipids in the endoplasmic reticulum (ER) bilayer. The ER mem ...
phospholipids, etc ; liquid-air interface; microscopy; silica; temperature; thermodynamics; Show all 6 Subjects
Abstract:
... Membranes of various phospholipids may separate into different domains at micrometer length scales at the air–water interface. A significant challenge is to visualize the molecular organization and obtain chemical information on this surface. Langmuir–Blodgett monolayers of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC) on fused silica were i ...
phospholipids, etc ; hydrophilicity; hydrophobicity; ligands; models; molecular dynamics; nanogold; permeability; Show all 8 Subjects
Abstract:
... The interaction of atomically precise monolayer thiolate (SR) protected gold nanoclusters (Au NCs) with the phospholipid membranes has been studied by the all-atom molecular dynamics (AAMD) simulations. The effect of cluster size, type, and the surface charge density of protection ligand was studied. The simulation results show gold nanoclusters with different size and surface modifications have m ...
phospholipids, etc ; dyes; encapsulation; evaporation; fatty acids; flocculation; prebiotics; surfactants; Show all 8 Subjects
Abstract:
... The first cell membranes were likely composed of single-chain amphiphiles such as fatty acids. An open question is whether fatty acid membranes could have functioned within evaporative lakes on the early Earth, which have been hypothesized to concentrate prebiotic reactants. Evaporation also concentrates monovalent salts, which in turn cause fatty acid membrane vesicles to flocculate; significant ...
phospholipids, etc ; Amoebozoa; Entamoeba histolytica; RNA; genes; humans; intestines; transcriptome; Show all 8 Subjects
Abstract:
... Entamoeba is a genus of Amoebozoa that includes the intestine-colonizing pathogenic species Entamoeba histolytica. To understand the basis of gene regulation in E. histolytica from an evolutionary perspective, we have profiled the transcriptomes of its closely related species E. dispar, E. moshkovskii and E. invadens. Genome-wide identification of transcription start sites (TSS) and polyadenylatio ...
phospholipids, etc ; cell membranes; deformation; dyes; ionic strength; pH; peptides; Show all 7 Subjects
Abstract:
... A real-time and molecule-level monitoring of the interfacial dynamic interactions between molecules and a cell membrane is of vital importance. Herein, taking TAT, one of the most representative cell penetrating peptides, as an example, a photo-voltage transient technique and a dynamic giant bistratal vesicle (GBV) leakage method were combined with the traditional giant unilamellar vesicle (GUV) l ...
phospholipids, etc ; galactolipids; metabolism; plant growth; salt stress; transcription (genetics); Show all 6 Subjects
Abstract:
... Salt stress limits plant growth and development. In this study, changes in membrane lipids were investigated in leaves of sorghum seedlings subjected to salt stress (150 mmol L⁻¹ NaCl). Galactolipids (DGDG and MGDG) accounted for more than 65% of the total glycerolipids in sorghum leaves. The predominance of C36 molecular species in MGDG suggested that sorghum is an 18:3 plant. Under NaCl treatmen ...
phospholipids, etc ; hydrophobicity; neurodegenerative diseases; peptides; physical chemistry; surfactants; toxicity; Show all 7 Subjects
Abstract:
... Huntington’s disease is a neurodegenerative disorder caused by an expanded polyglutamine (polyQ) domain within the huntingtin protein (htt) that initiates toxic protein aggregation. Htt directly interacts with membranes, influencing aggregation and spurring membrane abnormalities. These interactions are facilitated by the 17 N-terminal residues (Nt17) that form an amphipathic α-helix implicated in ...
phospholipids, etc ; glycinin; hydrocolloids; lipoxygenases; polysaccharides; soybean oil; soybeans; triacylglycerols; Show all 8 Subjects
Abstract:
... Soybean has small and stable oil bodies that make up 18%–22% of its total mass. These oil bodies are organized droplets of triacylglycerol rich in minor bioactive constituents. They are surrounded by a monolayer of phospholipids in which seven oleosins, two caleosins and one steroleosin are embedded. After standard aqueous extraction, the soybean oil bodies (SOBs) acquire a second protein layer co ...