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1. The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells

Author:
Li Li; Lingyi Xi; Jin Wu; Zunquan Zhao; Youliang Chen; Weili Liu; Zhihui Pan; Mingzhu Liu; Danfeng Yang; Zhaoli Chen; Yanjun Fang
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 823-830
ISSN:
1001-0742
Subject:
phosphorylation,   etc   ; DNA; Western blotting; apoptosis; autophagy; flame retardants; flow cytometry; humans; neurons; neurotoxicity; phosphates; protective effect; rats; China;     Show all 14 Subjects
Abstract:
... Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a commonly used organophosphate-based flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy. However, its regulatory mechanism remains un ...
DOI:
10.1016/j.jes.2022.02.046

2. Aflatoxin M1 and ochratoxin A induce a competitive endogenous RNA regulatory network of intestinal immunosuppression by whole-transcriptome analysis

Author:
Ya-Nan Gao; Zi-Wei Wang; Xue Yang; Jia-Qi Wang; Nan Zheng
Source:
Science of the total environment 2023 v.854 pp. 158777
ISSN:
0048-9697
Subject:
phosphorylation,   etc   ; aflatoxin M1; body weight; environment; human health; immunosuppression; immunotoxicity; intestines; mice; microRNA; milk; ochratoxin A; risk; transcriptome; transcriptomics;     Show all 15 Subjects
Abstract:
... Aflatoxin M1 (AFM1) and ochratoxin A (OTA) are common mycotoxins in cereal foods and milk products, and may cause serious negative impacts on human health. The intestine is crucial for immune regulation as it protects host homeostatic health from external contaminants; however, the underlying mechanisms of AFM1 and OTA mediated intestinal immunotoxicity remain unclear. In this study, whole transcr ...
DOI:
10.1016/j.scitotenv.2022.158777

3. Integrated multi-omic analyses on yellow Flammulina filiformis cultivar reveal postharvest oxidative damage responses

Author:
Yu Fu; Hao Tan; Bo Wang; Weihong Peng; Qun Sun; Yang Yu
Source:
Postharvest biology and technology 2023 v.195 pp. 112111
ISSN:
0925-5214
Subject:
oxidative phosphorylation,   etc   ; DNA; Flammulina; biosynthesis; catechol oxidase; cell senescence; cultivars; genome; laccase; melanin; mushrooms; oxygen; proteolysis; proteome; proteomics; technology; transcriptome; transcriptomics; tyrosine;     Show all 19 Subjects
Abstract:
... Yellow cultivars of Flammulina filiformis are prone to browning, which causes significant yearly loss. This study investigated the critical factors involved and revealed that oxygen plays an essential role in the browning process. Integrated multi-omic analyses, including genome sequencing, transcriptome profiling, and 4D label-free proteome quantification, were incorporated to dissect essential g ...
DOI:
10.1016/j.postharvbio.2022.112111

4. Discovery of a novel phosphotransferase from Bacillus subtilis that phosphorylates a broad spectrum of flavonoids

Author:
Chen Hsu; Hsin-Ya Tsai; Chi-Fon Chang; Chien-Chih Yang; Nan-Wei Su
Source:
Food chemistry 2023 v.400 pp. 134001
ISSN:
0308-8146
Subject:
phosphorylation,   etc   ; Bacillus subtilis; apigenin; bioavailability; biosynthesis; daidzein; dietary supplements; enzymes; food chemistry; genistein; hesperetin; kaempferol; luteolin; moieties; naringenin; orthophosphates; quercetin; regioselectivity; solubility;     Show all 19 Subjects
Abstract:
... Flavonoids are associated with health benefits, but most of them have poor oral bioavailability due to their extremely low aqueous solubility. Flavonoid O-phosphorylation suggests a potent modification to solve the problems. Here, we isolated, identified and characterized an unprecedented phosphotransferase, flavonoid phosphate synthetase (BsFPS), from B. subtilis. The enzyme catalyzes the ATP-dep ...
DOI:
10.1016/j.foodchem.2022.134001

5. Fate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics

Author:
Thibaut Léger; Patrick Balaguer; Ludovic Le Hégarat; Valérie Fessard
Source:
Journal of hazardous materials 2023 v.442 pp. 130083
ISSN:
0304-3894
Subject:
oxidative phosphorylation,   etc   ; beta oxidation; cell culture; cell lines; dose response; hepatocytes; humans; inflammation; interleukin-6; liver; metabolites; metabolomics; mitochondria; multiomics; pesticides; proteasome endopeptidase complex; proteomics; rats; secretion; transcription factors;     Show all 20 Subjects
Abstract:
... The biological effects of the pesticide and mitochondrial complex I inhibitor tebufenpyrad (TEBU) on liver cells were investigated by combining proteomics and metabolomics. Both cell culture media and cellular lysates were analyzed in dose-response and kinetic experiments on the HepaRG cell line. Responses were compared with those obtained on primary human and rat hepatocytes. A multitude of phase ...
DOI:
10.1016/j.jhazmat.2022.130083

6. Preserved egg white alleviates DSS-induced colitis in mice through the reduction of oxidative stress, modulation of infl ammatory cytokines, NF-κB, MAPK and gut microbiota composition

Author:
Lingyu Li; Ning Qiu; Yaqi Meng; Chenyan Wang; Yoshinori Mine; Russell Keast; Vincent Guyonnet
Source:
Food science and human wellness 2023 v.12 no.1 pp. 312-323
ISSN:
2213-4530
Subject:
phosphorylation,   etc   ; Lachnospiraceae; Proteobacteria; Ruminococcaceae; colitis; colon; cytokines; dextran sulfate; egg albumen; eggs; food science; gene expression; humans; intestinal microorganisms; mitogen-activated protein kinase; myeloperoxidase; oxidative stress; secretion; transcription factor NF-kappa B;     Show all 19 Subjects
Abstract:
... Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects, but their mechanisms of action remain unknown. This study aimed to investigate the anti-inflammatory effects of preserved egg white (PEW) treatment on dextran sulfate sodium (DSS)-induced colitis in mice and the underlying mechanisms. The results showed that treatment with PEW in mice with DSS-induced colitis ...
DOI:
10.1016/j.fshw.2022.07.021

7. A unique insight for Xiaoyao San exerts antidepressant effects by modulating hippocampal glucose catabolism using stable isotope-resolved metabolomics

Author:
Wen-ze Wu; Ting Ling-hu; Yun-hao Zhao; Wei-di Zhao; Cui Ji; Jun-sheng Tian; Yan Ren; Xue-mei Qin
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115702
ISSN:
0378-8741
Subject:
oxidative phosphorylation,   etc   ; Oriental traditional medicine; animal models; antidepressants; catabolism; enzyme activity; glucose; hippocampus; lactate dehydrogenase; liver; metabolites; metabolomics; mitochondria; molecular biology; pyruvate carboxylase; pyruvate dehydrogenase (lipoamide); spleen; stable isotopes; succinate dehydrogenase (quinone); transmission electron microscopy;     Show all 20 Subjects
Abstract:
... In traditional Chinese medicine (TCM) theory, depression is an emotional disease, which is thought to be related to stagnation of liver qi and dysfunction of the spleen in transport. Xiaoyao San (XYS) is considered to have the effects of soothing liver-qi stagnation and invigorating the spleen. The spleen has the function to transport and transform nutrients. The liver has also termed the center o ...
DOI:
10.1016/j.jep.2022.115702

8. 23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways

Author:
Chunyan Chen; Lin Li; Xiaomei Liu; Deqin Zhang; Yang Liu; Yuhong Li
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115725
ISSN:
0378-8741
Subject:
phosphorylation,   etc   ; Actaea cimicifuga; Oriental traditional medicine; Western blotting; blood serum; cytotoxicity; edema; enzyme-linked immunosorbent assay; eosin; fluorescent antibody technique; genes; glycosides; histopathology; interleukin-6; lipopolysaccharides; lung function; lungs; macrophages; models; nitric oxide; pharyngitis; plethysmography; protein content; rhizomes; therapeutics; toxicity testing; triterpenoids;     Show all 27 Subjects
Abstract:
... Cimicifuga foetida L. is a well-established traditional Chinese medicine with heat-clearing and detoxifying effects and has good therapeutic effect on oral mucosal ulcer and pharyngitis. The rhizome of this herb is rich in triterpenoid glycosides, including 23-O-acetylshengmanol-3-o-α-L-arabinoside (DA). Whether and how DA attenuates acute lung injury (ALI) are unclear. Accordingly, we focused on ...
DOI:
10.1016/j.jep.2022.115725

9. Anti-inflammatory and immunostimulant effect of different timing-related administration of dietary polyphenols on intestinal inflammation in zebrafish, Danio rerio

Author:
Roberta Imperatore; Graziella Orso; Serena Facchiano; Pierpaolo Scarano; Seyed Hossein Hoseinifar; Ghasem Ashouri; Carmine Guarino; Marina Paolucci
Source:
Aquaculture 2023 v.563 pp. 738878
ISSN:
0044-8486
Subject:
phosphorylation,   etc   ; Castanea sativa; Danio rerio; Verbascum; adults; antioxidant activity; antioxidants; aquaculture; assets; catalase; diet; feed additives; flavonoids; gene expression; immunostimulants; inflammation; interleukin-10; intestines; mitogen-activated protein kinase; models; polyphenols; prostaglandin synthase; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factors;     Show all 25 Subjects
Abstract:
... A short-term study was performed to assess the effects of diets supplemented with polyphenols (CSVP), extracted from the chestnut (Castanea sativa) shell, agri-food waste rich in tannins, and mullein (Verbascum macrurum), a perennial spontaneous plant rich in flavonoids, on a zebrafish (Danio rerio) model of k-carrageenan-induced intestinal inflammation. Morphological asset of intestine, immunoden ...
DOI:
10.1016/j.aquaculture.2022.738878

10. AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay

Author:
Hana Cho; Elizabeth T. Abshire; Maximilian W. Popp; Christoph Pröschel; Joshua L. Schwartz; Gene W. Yeo; Lynne E. Maquat
Source:
Molecular cell 2022 v.82 no.15 pp. 2779-2796.e10
ISSN:
1097-2765
Subject:
phosphorylation,   etc   ; adenosinetriphosphatase; mammals;     Show all 3 Subjects
Abstract:
... Despite a long appreciation for the role of nonsense-mediated mRNA decay (NMD) in destroying faulty, disease-causing mRNAs and maintaining normal, physiologic mRNA abundance, additional effectors that regulate NMD activity in mammalian cells continue to be identified. Here, we describe a haploid-cell genetic screen for NMD effectors that has unexpectedly identified 13 proteins constituting the AKT ...
DOI:
10.1016/j.molcel.2022.05.013

11. The phosphate ester group in secondary metabolites

Author:
Franco Della-Felice; Aloisio de Andrade Bartolomeu; Ronaldo Aloise Pilli
Source:
Natural product reports 2022 v.39 no.5 pp. 1066-1107
ISSN:
1460-4752
Subject:
phosphorylation,   etc   ; phosphates; secondary metabolites;     Show all 3 Subjects
Abstract:
... The phosphate ester is a versatile, widespread functional group involved in a plethora of biological activities. Its presence in secondary metabolites, however, is relatively rare compared to other functionalities and thus is part of a rather unexplored chemical space. Herein, the chemistry of secondary metabolites containing the phosphate ester group is discussed. The text emphasizes their struct ...
DOI:
10.1039/d1np00078k

12. Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

Author:
Ioannis Sanidas; Hanjun Lee; Purva H. Rumde; Gaylor Boulay; Robert Morris; Gabriel Golczer; Marcelo Stanzione; Soroush Hajizadeh; Jun Zhong; Meagan B. Ryan; Ryan B. Corcoran; Benjamin J. Drapkin; Miguel N. Rivera; Nicholas J. Dyson; Michael S. Lawrence
Source:
Molecular cell 2022 v.82 no.18 pp. 3333-3349.e9
ISSN:
1097-2765
Subject:
phosphorylation,   etc   ; cell cycle; chromatin;     Show all 3 Subjects
Abstract:
... The interaction of RB with chromatin is key to understanding its molecular functions. Here, for first time, we identify the full spectrum of chromatin-bound RB. Rather than exclusively binding promoters, as is often described, RB targets three fundamentally different types of loci (promoters, enhancers, and insulators), which are largely distinguishable by the mutually exclusive presence of E2F1, ...
DOI:
10.1016/j.molcel.2022.07.014

13. GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision

Author:
Wesley B. Asher; Daniel S. Terry; G. Glenn A. Gregorio; Alem W. Kahsai; Alessandro Borgia; Bing Xie; Arnab Modak; Ying Zhu; Wonjo Jang; Alekhya Govindaraju; Li-Yin Huang; Asuka Inoue; Nevin A. Lambert; Vsevolod V. Gurevich; Lei Shi; Robert J. Lefkowitz; Scott C. Blanchard; Jonathan A. Javitch
Source:
Cell 2022 v.185 no.10 pp. 1661-1675.e16
ISSN:
0092-8674
Subject:
phosphorylation,   etc   ; energy transfer; fluorescence; phosphopeptides;     Show all 4 Subjects
Abstract:
... β-arrestins bind G protein-coupled receptors to terminate G protein signaling and to facilitate other downstream signaling pathways. Using single-molecule fluorescence resonance energy transfer imaging, we show that β-arrestin is strongly autoinhibited in its basal state. Its engagement with a phosphopeptide mimicking phosphorylated receptor tail efficiently releases the β-arrestin tail from its N ...
DOI:
10.1016/j.cell.2022.03.042

14. Syntheses of Symmetrical and Unsymmetrical Lysobisphosphatidic Acid Derivatives

Author:
Kiran Chinthapally; Brian S. J. Blagg; Brandon L. Ashfeld
Source:
Journal of organic chemistry 2022 v.87 no.15 pp. 10523-10530
ISSN:
1520-6904
Subject:
phosphorylation,   etc   ; glycerol; organic chemistry; oxidation;     Show all 4 Subjects
Abstract:
... Recent years have witnessed significant achievements in the field of organic chemistry, which have led to new drugs and the discovery of new and biologically interesting molecules. Herein, we describe a practical and efficient approach to the synthesis of enantiomerically pure and diverse lysobisphosphatidic acid analogues. The key feature of the synthesis is a one-pot, sequential phosphorylation ...
DOI:
10.1021/acs.joc.2c01176

15. A single evolutionarily divergent mutation determines the different FAD‐binding affinities of human and rat NQO1 due to site‐specific phosphorylation

Author:
Juan Luis Pacheco‐Garcia; Dmitry Loginov; Bruno Rizzuti; Pavla Vankova; Jose L. Neira; Daniel Kavan; Noel Mesa‐Torres; Rita Guzzi; Petr Man; Angel L. Pey
Source:
FEBS letters 2022 v.596 no.1 pp. 29-41
ISSN:
0014-5793
Subject:
phosphorylation,   etc   ; bioinformatics; humans; mutation; rats;     Show all 5 Subjects
Abstract:
... The phosphomimetic mutation S82D in the cancer‐associated, FAD‐dependent human NADP(H):quinone oxidoreductase 1 (hNQO1) causes a decrease in flavin‐adenine dinucleotide‐binding affinity and intracellular stability. We test in this work whether the evolutionarily recent neutral mutation R80H in the vicinity of S82 may alter the strong functional effects of S82 phosphorylation through electrostatic ...
DOI:
10.1002/1873-3468.14238

16. Copper-Catalyzed Phosphorylation of N,N-Disubstituted Hydrazines: Synthesis of Multisubstituted Phosphorylhydrazides as Potential Anticancer Agents

Author:
Lvyin Zheng; Liuhuan Cai; Weijie Mei; Gongping Liu; Ling Deng; Xiaoying Zou; Xiaoya Zhuo; Yumei Zhong; Wei Guo
Source:
Journal of organic chemistry 2022 v.87 no.9 pp. 6224-6236
ISSN:
1520-6904
Subject:
phosphorylation,   etc   ; hydrogen; neoplasms; organic chemistry;     Show all 4 Subjects
Abstract:
... An efficient copper-catalyzed aerobic oxidative cross-dehydrogenative coupling reaction for the synthesis of multisubstituted phosphorylhydrazides from N,N-disubstituted hydrazines and hydrogen phosphoryl compounds is accomplished. The reaction proceeds under mild conditions without the addition of any external oxidants and bases. This work reported here represents a direct P(═O)–N–N bond formatio ...
DOI:
10.1021/acs.joc.2c00452

17. C‐terminal–mediated homodimerization of Expanded is critical for its ability to promote Hippo signalling in Drosophila

Author:
Guiping Wang; Chaojun Zhai; Xiaohui Ji; Enlin Wang; Shanshan Zhao; Chenxi Qian; Dongyue Yu; Yunfeng Wang; Shian Wu
Source:
FEBS letters 2022 v.596 no.13 pp. 1628-1638
ISSN:
0014-5793
Subject:
phosphorylation,   etc   ; Drosophila; dimerization; homeostasis; humans;     Show all 5 Subjects
Abstract:
... Hippo signalling plays key role in tissue growth and homeostasis, and its dysregulation is implicated in various human diseases. Expanded (Ex) is an important upstream activator of Hippo signalling; however, how Ex activates Hippo signalling is still poorly understood. Here, we demonstrate that Ex forms a homodimer via C‐terminal interaction, and that the ExC2 region (912–1164 aa) is sufficient an ...
DOI:
10.1002/1873-3468.14332

18. Autophosphorylation transforms DNA-PK from protecting to processing DNA ends

Author:
Lan Liu; Xuemin Chen; Jun Li; Huaibin Wang; Christopher J. Buehl; Noah J. Goff; Katheryn Meek; Wei Yang; Martin Gellert
Source:
Molecular cell 2022 v.82 no.1 pp. 177-189.e4
ISSN:
1097-2765
Subject:
protein phosphorylation,   etc   ; DNA; protein kinases;     Show all 3 Subjects
Abstract:
... The DNA-dependent protein kinase (DNA-PK) initially protects broken DNA ends but then promotes their processing during non-homologous end joining (NHEJ). Before ligation by NHEJ, DNA hairpin ends generated during V(D)J recombination must be opened by the Artemis nuclease, together with autophosphorylated DNA-PK. Structures of DNA-PK bound to DNA before and after phosphorylation, and in complex wit ...
DOI:
10.1016/j.molcel.2021.11.025
CHORUS:
10.1016/j.molcel.2021.11.025

19. Specific Features of Regulation of Hormonal Sensitivity in Stem Cells

Author:
V. I. Chechekhin; K. Y. Kulebyakin; P. A. Tyurin-Kuzmin
Source:
Russian journal of developmental biology 2022 v.53 no.3 pp. 151-158
ISSN:
1062-3604
Subject:
phosphorylation,   etc   ; adults; homeostasis; neurotransmitters; tissue repair;     Show all 5 Subjects
Abstract:
... The normal functioning of the adult organism is based on the processes of maintaining homeostasis, tissue repair, and regeneration. An important role in the regulation of these processes is played by a special group of postnatal stem cells: multipotent mesenchymal stromal cells (MSCs). The functional activity of MSCs is under strict neuroendocrine control. In this review, the features of the mecha ...
DOI:
10.1134/S106236042203002X

20. The influence of prorenin/(pro)renin receptor on progesterone secretion by the bovine corpus luteum

Author:
Andressa Minussi Pereira Dau; Paulo Roberto da Rosa; Joabel dos Santos; Juliana Ferst; Mariana de Macedo; Monique Rovani; Fabio Comim; Alfredo Quites Antoniazzi; Bernardo Gasperin; Rogério Ferreira; Paulo Bayard Gonçalves
Source:
Animal reproduction science 2022 v.241 pp. 106985
ISSN:
0378-4320
Subject:
phosphorylation,   etc   ; antagonists; luteolysis; progesterone; renin; secretion;     Show all 6 Subjects
Abstract:
... The aim of this study was to evaluate the role of prorenin/(pro)renin receptor activation on luteal progesterone (P4) secretion. Our hypothesis was that the nonproteolytic activation of (pro)renin receptor [P(RR)] is part of the regulatory mechanism responsible for corpus luteum (CL) function. In the first three experiments, prorenin was found to stimulate the production of P4, which is not inhibi ...
DOI:
10.1016/j.anireprosci.2022.106985