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1. When Separation Causes Activation: Biophysical Control of Bulk Autophagy Initiation

Author:
Bhattacharya, Debjani; Behrends, Christian
Source:
Molecular cell 2020 v.78 no.3 pp. 379-381
ISSN:
1097-2765
Subject:
phosphorylation,   etc   ; autophagosomes; autophagy; enzymes; separation; yeasts;     Show all 6 Subjects
Abstract:
... Fujioka et al. (2020) uncovered liquid-liquid phase separation of the PAS, a key driver of autophagosome formation in yeast. Moreover, the authors demonstrated that liquid-like PAS controls autophagic kinase activation and is itself regulated by the phosphorylation status of its constituents. ...
DOI:
10.1016/j.molcel.2020.04.015

2. Enrichments of post‐translational modifications in proteomic studies

Author:
Pieroni, Luisa; Iavarone, Federica; Olianas, Alessandra; Greco, Viviana; Desiderio, Claudia; Martelli, Claudia; Manconi, Barbara; Sanna, Maria Teresa; Messana, Irene; Castagnola, Massimo; Cabras, Tiziana
Source:
Journal of separation science 2020 v.43 no.1 pp. 313-336
ISSN:
1615-9306
Subject:
phosphorylation,   etc   ; acetylation; glycation; glycosylation; methylation; proteins; proteomics;     Show all 7 Subjects
Abstract:
... More than 300 different protein post‐translational modifications are currently known, but only a few have been extensively investigated because modified proteoforms are commonly present in sub‐stoichiometry amount. For this reason, improvement of specific enrichment techniques is particularly useful for the proteomic characterization of post‐translationally modified proteins. Enrichment proteomic ...
DOI:
10.1002/jssc.201900804

3. In Silico Evolution of Biochemical Log-Response

Author:
Hemery, Mathieu; François, Paul
Source:
TheJournal of physical chemistry 2019 v.123 no.10 pp. 2235-2243
ISSN:
1520-5207
Subject:
phosphorylation,   etc   ; algorithms; chemotaxis; ligands;     Show all 4 Subjects
Abstract:
... Numerous biological systems are known to harbor a form of logarithmic behavior, from Weber’s law to bacterial chemotaxis. Such a log-response allows for sensitivity to small relative variations of biochemical inputs over a large range of concentration values. Here we use a genetic algorithm to evolve biochemical networks displaying a logarithmic response. A quasi-perfect log-response implemented b ...
DOI:
10.1021/acs.jpcb.8b10974

4. Role of phosphorylation on characteristics of glycogen phosphorylase in lamb with different glycolytic rates post-mortem

Author:
Bai, Yuqiang; Li, Xin; Zhang, Dequan; Chen, Li; Hou, Chengli; Zheng, Xiaochun; Ren, Chi; Ijaz, Muawuz
Source:
Meat science 2020 v.164 pp. 108096
ISSN:
0309-1740
Subject:
phosphorylation,   etc   ; enzyme activity; glycogen; glycolysis; lambs; longissimus muscle; pH; phosphorylase;     Show all 8 Subjects
Abstract:
... The relationship between glycogen phosphorylase activity and phosphorylation levels in the longissimus thoracis muscle post-mortem was studied. Sixty lamb samples were collected at 0.5 h, 2 h, 6 h, 12 h, 24 h, 48 h, and 72 h post-mortem and divided into three groups (n = 6) with different glycolytic rates (fast, intermediate, and slow) according to the pH at 6 h post-mortem. The phosphorylation le ...
DOI:
10.1016/j.meatsci.2020.108096

5. Palladium-catalyzed phosphorylation of benzyl ammonium triflates with P(O)H compounds

Author:
Liu, Long; Xu, Kaiqiang; Wang, Yuan; Wang, Wenqi; Xu, Hanshuang; Huang, Tianzeng; Chen, Tieqiao
Source:
Tetrahedron 2020 v.76 no.13 pp. 131020
ISSN:
0040-4020
Subject:
phosphorylation,   etc   ; catalytic activity; moieties; oxides; palladium; phosphine; phosphonates;     Show all 7 Subjects
Abstract:
... A palladium-catalyzed phosphorylation of benzyl ammonium triflates with P(O)H compounds has been developed. Various benzylphosphorus compounds were produced in good to excellent yields with high functional group tolerance. All the three kinds of hydrogen phosphoryl compounds, i.e. H-phosphonates, H-phosphinates and secondary phosphine oxides, were applicable to this reaction. The successful scale- ...
DOI:
10.1016/j.tet.2020.131020

6. Crosstalk between Ubiquitination and Other Post-translational Protein Modifications in Plant Immunity

Author:
Zhang, Yi; Zeng, Lirong
Source:
Plant communications 2020 pp. 100041
ISSN:
2590-3462
Subject:
phosphorylation,   etc   ; acetylation; glycosylation; humans; immunity; pathogens; proteins; proteome; sumoylation; yeasts;     Show all 10 Subjects
Abstract:
... Post-translational modifications (PTMs) are central to the modulation of protein activity, stability, subcellular localization, and interaction with partners. They greatly expand the diversity and functionality of the proteome and have taken the center stage as key players in regulating numerous cellular and physiological processes. Increasing evidence indicates that in addition to a single regula ...
DOI:
10.1016/j.xplc.2020.100041

7. An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

Author:
Odle, Richard I.; Walker, Simon A.; Oxley, David; Kidger, Andrew M.; Balmanno, Kathryn; Gilley, Rebecca; Okkenhaug, Hanneke; Florey, Oliver; Ktistakis, Nicholas T.; Cook, Simon J.
Source:
Molecular cell 2020 v.77 no.2 pp. 228-240.e7
ISSN:
1097-2765
Subject:
phosphorylation,   etc   ; Animalia; genome; lysosomes; macroautophagy; mitosis; nuclear membrane;     Show all 7 Subjects
Abstract:
... Since nuclear envelope breakdown occurs during mitosis in metazoan cells, it has been proposed that macroautophagy must be inhibited to maintain genome integrity. However, repression of macroautophagy during mitosis remains controversial and mechanistic detail limited to the suggestion that CDK1 phosphorylates VPS34. Here, we show that initiation of macroautophagy, measured by the translocation of ...
DOI:
10.1016/j.molcel.2019.10.016
PubMed:
31733992
PubMed Central:
PMC6964153

8. Does postactivation potentiation (PAP) increase voluntary performance?

Author:
Zimmermann, Haiko Bruno; MacIntosh, Brian R.; Dal Pupo, Juliano
Source:
Applied physiology, nutrition and metabolism 2020 v.45 no.4 pp. 349-356
ISSN:
1715-5320
Subject:
phosphorylation,   etc   ; electrical treatment; metabolism; myosin light chains; nutrition; torque;     Show all 6 Subjects
Abstract:
... The transient increase in torque of an electrically evoked twitch following a voluntary contraction is called postactivation potentiation (PAP). Phosphorylation of myosin regulatory light chains is the most accepted mechanism explaining the enhanced electrically evoked twitch torque. While many authors attribute voluntary postactivation performance enhancement (PAPE) to the positive effects of PAP ...
DOI:
10.1139/apnm-2019-0406

9. The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora

Author:
Wang, Bin; Kettenbach, Arminja N.; Zhou, Xiaoying; Loros, Jennifer J.; Dunlap, Jay C.
Source:
Molecular cell 2019 v.74 no.4 pp. 771-784.e3
ISSN:
1097-2765
Subject:
phosphorylation,   etc   ; Neurospora; cryptochromes; genes; transactivators;     Show all 5 Subjects
Abstract:
... In the negative feedback loop driving fungal and animal circadian oscillators, negative elements (FREQUENCY [FRQ], PERIODS [PERs], and CRYPTOCHROMES [CRYs]) are understood to inhibit their own expression, in part by promoting the phosphorylation of their heterodimeric transcriptional activators (e.g., White Collar-1 [WC-1]-WC-2 [White Collar complex; WCC] and BMAL1/Circadian Locomotor Output Cycle ...
DOI:
10.1016/j.molcel.2019.03.003
PubMed:
30954403
PubMed Central:
PMC6583785

10. Omics analysis of holoproteins and modified proteins of quail egg

Author:
Liu, Lan; Yang, Ran; Luo, Xin; Dong, Kai; Huang, Xiang; Song, Hongbo; Gao, Hui; Li, Shugang; Huang, Qun
Source:
Food chemistry 2020 v.326 pp. 126983
ISSN:
0308-8146
Subject:
phosphorylation,   etc   ; chemical structure; egg proteins; eggs; enzyme activity; glycosylation; growth and development; humans; nutrients; phosphoproteins; quails;     Show all 11 Subjects
Abstract:
... Confirmed to be a new type of food resource, quail egg can provide humans with high-quality protein and offer various nutrients that can promote growth and development. Post-translational modification of proteins can regulate their molecular structures and physiological functions. However, the understanding and related research of quail egg holoproteins and post-translationally modified proteins i ...
DOI:
10.1016/j.foodchem.2020.126983

11. GCN5 acetylation is required for craniofacial chondrocyte maturation

Author:
Pezoa, Sofia A.; Artinger, Kristin B.; Niswander, Lee A.
Source:
Developmental biology 2020 v.464 no.1 pp. 24-34
ISSN:
0012-1606
Subject:
phosphorylation,   etc   ; acetylation; acetyltransferases; chondrocytes; enzyme activity; epigenetics; histones; mice; neural crest; osteoblasts; pharynx;     Show all 11 Subjects
Abstract:
... Development of the craniofacial structures requires the precise differentiation of cranial neural crest cells into osteoblasts or chondrocytes. Here, we explore the epigenetic and non-epigenetic mechanisms that are required for the development of craniofacial chondrocytes. We previously demonstrated that the acetyltransferase activity of the highly conserved acetyltransferase GCN5, or KAT2A, is re ...
DOI:
10.1016/j.ydbio.2020.05.006

12. TMEM70 functions in the assembly of complexes I and V

Author:
Sánchez-Caballero, Laura; Elurbe, Dei M.; Baertling, Fabian; Guerrero-Castillo, Sergio; van den Brand, Mariel; van Strien, Joeri; van Dam, Teunis J.P.; Rodenburg, Richard; Brandt, Ulrich; Huynen, Martijn A.; Nijtmans, Leo G.J.
Source:
Biochimica et biophysica acta 2020 v.1861 no.8 pp. 148202
ISSN:
0005-2728
Subject:
oxidative phosphorylation,   etc   ; coevolution; congenital abnormalities; humans; membrane proteins; mitochondria; mitochondrial membrane; mutation;     Show all 8 Subjects
Abstract:
... Protein complexes from the oxidative phosphorylation (OXPHOS) system are assembled with the help of proteins called assembly factors. We here delineate the function of the inner mitochondrial membrane protein TMEM70, in which mutations have been linked to OXPHOS deficiencies, using a combination of BioID, complexome profiling and coevolution analyses. TMEM70 interacts with complex I and V and for ...
DOI:
10.1016/j.bbabio.2020.148202

13. PHF23 negatively regulates the autophagy of chondrocytes in osteoarthritis

Author:
Maimaitijuma, Talatibaike; Yu, Jia-Hong; Ren, Ya-Li; Yang, Xin; Liu, Heng; Meng, Zhi-Chao; Wang, Rui; Cui, Yun-Peng; Wu, Hao; Pan, Li-Ping; Jiao, Yang; Chen, Ying-Yu; Cao, Yong-Ping
Source:
Life sciences 2020 v.253 pp. 117750
ISSN:
0024-3205
Subject:
phosphorylation,   etc   ; Western blotting; autophagosomes; cell viability; chloroquine; chondrocytes; collagen; elderly; interleukins; lysosomes; mitophagy; osteoarthritis; staining; surgery;     Show all 14 Subjects
Abstract:
... Osteoarthritis (OA) is the main cause of disability and joint replacement surgery in the elderly. As a crucial cell survival mechanism, autophagy has been reported to decrease in OA. PHF23 is a new autophagy inhibitor which was first reported by us previously. This study aimed to explore the anti-autophagic mechanism of PHF23 to make it a possible therapeutic target of OA.Lentiviral vectors specif ...
DOI:
10.1016/j.lfs.2020.117750

14. Roles of N-terminal Annexin A2 phosphorylation sites and miR-206 in colonic adenocarcinoma

Author:
Xiao, Li; Jin, Huijuan; Duan, Wei; Hou, Yingchun
Source:
Life sciences 2020 v.253 pp. 117740
ISSN:
0024-3205
Subject:
phosphorylation,   etc   ; actin; adenocarcinoma; bioinformatics; luciferase; microstructure; mutation; neoplasm cells; polymerization; therapeutics; tubulin;     Show all 11 Subjects
Abstract:
... Annexin A2 (ANXA2) is closely associated with tumor malignancy and its N-terminus includes a vital domain for its function. The aims are to explore the correlation between the sites (Tyr23, Ser1, Ser11 and Ser25) in the domain and its roles.We re-expressed ANXA2 with mutated sites in ANXA2-deleted human colonic adenocarcinoma cell line caco2 (ANXA2-/-caco2). A series of analyses were used to deter ...
DOI:
10.1016/j.lfs.2020.117740

15. Alternative pathways control actomyosin contractility in epitheliomuscle cells during morphogenesis and body contraction

Author:
Holz, Oliver; Apel, David; Hassel, Monika
Source:
Developmental biology 2020 v.463 no.1 pp. 88-98
ISSN:
0012-1606
Subject:
phosphorylation,   etc   ; Hydra; adults; ectoderm; epithelium; morphogenesis; muscles; myosin; myosin light chain kinase;     Show all 9 Subjects
Abstract:
... In adult Hydra, epitheliomuscle cells form the monolayered ecto- and endodermal epithelia. Their basal myonemes function as a longitudinal and circular muscle, respectively. Based on the observation that a Rho/Rock pathway, controlling the cell shape changes during detachment of Hydra buds, is not involved in body movement, at least two actomyosin compartments must exist in these cells: a basal on ...
DOI:
10.1016/j.ydbio.2020.04.001

16. 5-HT2A receptor-mediated PKCδ phosphorylation is critical for serotonergic impairments induced by p-chloroamphetamine in mice

Author:
Phan, Dieu Hien; Shin, Eun-Joo; Sharma, Naveen; Hoang Yen, Tran Phi; Dang, Duy-Khanh; Lee, Yong Sup; Lee, Yu Jeung; Nah, Seung-Yeol; Cheong, Jae Hoon; Jeong, Ji Hoon; Kim, Hyoung-Chun
Source:
Food and chemical toxicology 2020 v.141 pp. 111395
ISSN:
0278-6915
Subject:
phosphorylation,   etc   ; amphetamine; antagonists; enzyme inhibitors; gene expression; genes; mice; neurotoxicity; protein kinase C; toxicology;     Show all 10 Subjects
Abstract:
... p-Chloroamphetamine (PCA), an amphetamine derivative, has been shown to induce serotonergic toxicity. However, the precise mechanism of serotonergic toxicity induced by PCA remains unclear. In this study, PCA treatment (20 mg/kg, i.p.) did not significantly change 5-HT₁A receptor gene expression, but significantly increased 5-HT₂A receptor gene expression. Furthermore, 5-HT₂A receptor antagonist M ...
DOI:
10.1016/j.fct.2020.111395

17. Mitochondrial proteomics profile points oxidative phosphorylation as main target for beauvericin and enniatin B mixture

Author:
Alonso-Garrido, M.; Manyes, L.; Pralea, I.E.; Iuga, C.A.
Source:
Food and chemical toxicology 2020 v.141 pp. 111432
ISSN:
0278-6915
Subject:
oxidative phosphorylation,   etc   ; Fusarium; mitochondria; mycotoxins; neurodegenerative diseases; proteins; proteomics; ribosomes; toxicology;     Show all 9 Subjects
Abstract:
... Beauvericin (BEA) and enniatin B (EN B) are non-legislated Fusarium mycotoxins usually found in cereal and cereal-based products all around the world. By the proteomic analysis of mitochondria enriched extracts from Jurkat cells exposed for 24 h to three concentrations of BEA:EN B (0.01–0.1–0.5 μM), a number of 1821 proteins (202 mitochondrial) were identified and relatively quantified. 340 protei ...
DOI:
10.1016/j.fct.2020.111432

18. Synopsis of recent synthetic methods and biological applications of phosphinic acid derivatives

Author:
Abdou, Moaz M.
Source:
Tetrahedron 2020 v.76 no.25 pp. 131251
ISSN:
0040-4020
Subject:
phosphorylation,   etc   ; acids; aldehydes; alkenes; allylation; benzylation; cross-coupling reactions; drugs; enantiomers; enzyme inhibitors; enzymes; heterocyclic compounds;     Show all 12 Subjects
Abstract:
... The chemistry of phosphinic acid derivatives has attracted increasing attention in both synthetic organic and biological fields, and great progress in the application of such compounds has been achieved in recent years. This review aims to document a systematic account of the prevailing methods for the synthesis of acyclic/cyclic phosphinic acids either in enantiopure or in racemic form. The most ...
DOI:
10.1016/j.tet.2020.131251

19. High ErbB3 activating activity in human blood is not due to circulating neuregulin-1 beta

Author:
Boateng, Emmanuel; deKay, Joanne T.; Peterson, Sarah M.; Boles, Jacob; Pinnette, Nathan; Sorcher, Mary W.; Robich, Michael P.; Sawyer, Douglas B.; Ryzhov, Sergey
Source:
Life sciences 2020 v.251 pp. 117634
ISSN:
0024-3205
Subject:
phosphorylation,   etc   ; blood plasma; cell viability; enzyme-linked immunosorbent assay; humans; inflammation; neutralizing antibodies; receptors;     Show all 8 Subjects
Abstract:
... Neuregulin-1β (NRG-1) is a membrane-bound or secreted growth and differentiation factor that mediates its action by binding to ErbB receptors. Circulating levels of NRG-1 are characterized by large inter-individual variability with the range of absolute values covering two orders of magnitude, from hundreds to tens of thousands of picograms per milliliter of blood. NRG-1 signaling via ErbB recepto ...
DOI:
10.1016/j.lfs.2020.117634
PubMed:
32251632
PubMed Central:
PMC7233313

20. The proportion of tyrosine phosphorylated spermatozoa in cryopreserved semen is negatively related to crossbred bull fertility

Author:
Vignesh, Kolanjiyappan; Murugavel, Kailasam; Antoine, Dourey; Prakash, Mani Arul; Saraf, Kausthub Kishore; Nag, Pradeep; Karuthadurai, Thirumalaisamy; Kumaresan, Arumugam
Source:
Theriogenology 2020 v.149 pp. 46-54
ISSN:
0093-691X
Subject:
phosphorylation,   etc   ; acrosome; acrosome reaction; bulls; crossbreds; cryopreservation; male fertility; semen; sperm motility; tyrosine;     Show all 10 Subjects
Abstract:
... Sub-fertility is a major problem in crossbred bulls. Identification of subtle differences in the quality of cryopreserved spermatozoa among bulls belonging to different fertility rankings would help determine the latent fertility of semen before their use at field conditions. In the present study, we assessed the status of tyrosine phosphorylation, membrane integrity and acrosome reaction of cryop ...
DOI:
10.1016/j.theriogenology.2020.03.020