U.S. flag

An official website of the United States government

PubAg

Main content area

You searched for: Subject "phosphorylation" Remove constraint Subject: "phosphorylation"
Start Over

Search

20,930  Search Results

« Previous | 1 - 20 of 20,930 |
Number of results to display per page

Search Results

1. Modulation of corticosterone and changes of signal molecules in the HPA axis after cold water swimming stress

Author:
Feng, Jing Hui; Sim, Su Min; Park, Jung Seok; Hong, Jae Seung; Suh, HongWon
Source:
Animal cells and systems 2021 v.25 no.1 pp. 37-45
ISSN:
2151-2485
Subject:
phosphorylation,   etc   ; corticosterone; water;     Show all 3 Subjects
Abstract:
... In the present study, we examined the effect of cold-water swimming stress (CWSS) on plasma corticosterone levels. Mice were exposed to stress in 4°C for 3 mins. Plasma corticosterone (CORT) level was measured at 0, 15, and 30 min after stress stimulation. The plasma CORT level was gradually increased up to 30 min. Then we further examined the changes of several signaling molecules expression leve ...
DOI:
10.1080/19768354.2021.1890211

2. LFA-1 cluster formation in T-cells depends on L-plastin phosphorylation regulated by P90RSK and PP2A

Author:
Wabnitz, Guido H.; Honus, Sibylle; Habicht, Jüri; Orlik, Christian; Kirchgessner, Henning; Samstag, Yvonne
Source:
Cellular and molecular life sciences 2021 v.78 no.7 pp. 3543-3564
ISSN:
1420-682X
Subject:
phosphorylation,   etc   ; T-lymphocytes; dephosphorylation; integrins;     Show all 4 Subjects
Abstract:
... The integrin LFA-1 is crucial for T-cell/ APC interactions and sensitive recognition of antigens. Precise nanoscale organization and valency regulation of LFA-1 are mandatory for an appropriate function of the immune system. While the inside-out signals regulating the LFA-1 affinity are well described, the molecular mechanisms controlling LFA-1 avidity are still not fully understood. Here, we show ...
DOI:
10.1007/s00018-020-03744-z

3. A conserved sequence motif bridges two protein kinases for enhanced phosphorylation and nuclear function of a splicing factor

Author:
Aubol, Brandon E.; Fattet, Laurent; Adams, Joseph A.
Source:
TheFEBS journal 2021 v.288 no.2 pp. 566-581
ISSN:
1742-464X
Subject:
protein phosphorylation,   etc   ; protein kinases; spliceosomes;     Show all 3 Subjects
Abstract:
... The assembly and activation of the spliceosome rely upon the phosphorylation of an essential family of splicing factors known as the serine–arginine (SR) proteins. Although it has been demonstrated recently that two enzyme families, the SR protein kinases (SRPKs) and the Cdc2‐like kinases (CLKs), can function as a complex to efficiently phosphorylate these SR proteins in the nucleus, the molecular ...
DOI:
10.1111/febs.15351

4. Qiliqiangxin alleviates Ang II-induced CMECs apoptosis by downregulating autophagy via the ErbB2-AKT-FoxO3a axis

Author:
Li, Fuhai; Wang, Jingfeng; Song, Yu; Shen, Dongli; Zhao, Yongchao; Li, Chaofu; Fu, Mingqiang; Wang, Yanyan; Qi, Baozheng; Han, Xueting; Sun, Aijun; Zhou, Jingmin; Ge, Junbo
Source:
Life sciences 2021 v.273 pp. 119239
ISSN:
0024-3205
Subject:
phosphorylation,   etc   ; apoptosis; autophagosomes; autophagy; protective effect; rapamycin;     Show all 6 Subjects
Abstract:
... Our previous work revealed the protective effect of Qiliqiangxin (QLQX) on cardiac microvascular endothelial cells (CMECs), but the underlying mechanisms remain unclear. We aimed to investigate whether QLQX exerts its protective effect against high-concentration angiotensin II (Ang II)-induced CMEC apoptosis through the autophagy machinery. CMECs were cultured in high-concentration Ang II (1 μM) m ...
DOI:
10.1016/j.lfs.2021.119239

5. Phosphorylation of OsFD1 by OsCIPK3 promotes the formation of RFT1-containing florigen activation complex for long-day flowering in rice

Author:
Peng, Qiang; Zhu, Chunmei; Liu, Tao; Zhang, Shuo; Feng, Shijing; Wu, Changyin
Source:
Molecular plant 2021
ISSN:
1674-2052
Subject:
phosphorylation,   etc   ; domestication; florigen; mutation; protein kinases; rice;     Show all 6 Subjects
Abstract:
... Heading date is a critical trait that determines the regional adaptability and grain productivity of many crops. Although rice is a facultative short-day plant, its domestication led to the Ghd7-Ehd1-Hd3a/RFT1 pathway for adaptation to long-day conditions (LDs). The formation of the “florigen activation complex” (FAC) containing florigen Hd3a has been characterized. However, the molecular composit ...
DOI:
10.1016/j.molp.2021.04.003

6. Phosphorylated full‐length Tau interacts with 14‐3‐3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14‐3‐3 dimer

Author:
Neves, João Filipe; Petrvalská, Olivia; Bosica, Francesco; Cantrelle, François‐Xavier; Merzougui, Hamida; O'Mahony, Gavin; Hanoulle, Xavier; Obšil, Tomáš; Landrieu, Isabelle
Source:
TheFEBS journal 2021 v.288 no.6 pp. 1918-1934
ISSN:
1742-464X
Subject:
phosphorylation,   etc   ; drugs; peptides; stoichiometry; surfactants; ultracentrifugation;     Show all 6 Subjects
Abstract:
... Protein–protein interactions (PPIs) remain poorly explored targets for the treatment of Alzheimer’s disease. The interaction of 14‐3‐3 proteins with Tau was shown to be linked to Tau pathology. This PPI is therefore seen as a potential target for Alzheimer’s disease. When Tau is phosphorylated by PKA (Tau‐PKA), several phosphorylation sites are generated, including two known 14‐3‐3 binding sites, ...
DOI:
10.1111/febs.15574

7. SPEECHLESS and MUTE Mediate Feedback Regulation of Signal Transduction during Stomatal Development

Author:
Wakeel, Abdul; Wang, Lin; Xu, Ming
Source:
Plants 2021 v.10 no.3
ISSN:
2223-7747
Subject:
phosphorylation,   etc   ; gas exchange; ligands; photosynthesis; signal transduction;     Show all 5 Subjects
Abstract:
... Stomatal density, spacing, and patterning greatly influence the efficiency of gas exchange, photosynthesis, and water economy. They are regulated by a complex of extracellular and intracellular factors through the signaling pathways. After binding the extracellular epidermal patterning factor 1 (EPF1) and 2 (EPF2) as ligands, the receptor-ligand complexes activate by phosphorylation through the MA ...
DOI:
10.3390/plants10030432

8. How CD40L reverse signaling regulates axon and dendrite growth

Author:
Carriba, Paulina; Davies, Alun M.
Source:
Cellular and molecular life sciences 2021 v.78 no.3 pp. 1065-1083
ISSN:
1420-682X
Subject:
phosphorylation,   etc   ; ; axons; mice; precipitin tests; tyrosine;     Show all 6 Subjects
Abstract:
... CD40-activated CD40L reverse signaling is a major physiological regulator of axon and dendrite growth from developing hippocampal pyramidal neurons. Here we have studied how CD40L-mediated reverse signaling promotes the growth of these processes. Cultures of hippocampal pyramidal neurons were established from Cd40⁻/⁻ mouse embryos to eliminate endogenous CD40/CD40L signaling, and CD40L reverse sig ...
DOI:
10.1007/s00018-020-03563-2

9. The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis

Author:
Nimmanon, Thirayost; Ziliotto, Silvia; Ogle, Olivia; Burt, Anna; Gee, Julia M. W.; Andrews, Glen K.; Kille, Pete; Hogstrand, Christer; Maret, Wolfgang; Taylor, Kathryn M.
Source:
Cellular and molecular life sciences 2021 v.78 no.4 pp. 1781-1798
ISSN:
1420-682X
Subject:
phosphorylation,   etc   ; microtubules; mitosis; therapeutics; transcription factors; zinc;     Show all 6 Subjects
Abstract:
... Zinc has been known to be essential for cell division for over 40 years but the molecular pathways involved remain elusive. Cellular zinc import across biological membranes necessitates the help of zinc transporters such as the SLC39A family of ZIP transporters. We have discovered a molecular process that explains why zinc is required for cell division, involving two highly regulated zinc transpor ...
DOI:
10.1007/s00018-020-03616-6

10. Controlling Kinase Activities by Selective Inhibition of Peptide Substrates

Author:
Li, Xiaowei; Palhano Zanela, Tania M.; Underbakke, Eric S.; Zhao, Yan
Source:
Journal of the American Chemical Society 2021 v.143 no.2 pp. 639-643
ISSN:
1520-5126
Subject:
phosphorylation,   etc   ; ; enzymes; peptides; post-translational modification;     Show all 5 Subjects
Abstract:
... Phosphorylation is the most common reversible post-translational modification (PTM) of proteins. Because a given kinase often has many substrates in a cell and is involved in numerous functions, traditional inhibition of the enzyme leads to unintended consequences. Here we report synthetic receptors to manipulate kinase phosphorylation precisely for the first time, utilizing the receptors’ abiliti ...
DOI:
10.1021/jacs.0c11566

11. Modeling the activity of the dopamine signaling pathway by combination of analog electrical circuit and mathematical approaches

Author:
Shumilov, A.V.; Gotovtsev, P.M.
Source:
Heliyon 2021 v.7 no.1 pp. e05879
ISSN:
2405-8440
Subject:
phosphorylation,   etc   ; calcium; dopamine; electronic circuits; mathematical models;     Show all 5 Subjects
Abstract:
... This paper demonstrates the application of the system biology principles on the example of the dopamine signaling pathway in neurons. Presented model is based on two approaches – cytomorphic electronic circuits and mathematical modeling. Transcription and phosphorylation of DARPP-32 was modeled by analog circuit, based on well-known approaches presented in [1]. It was shown that application of cir ...
DOI:
10.1016/j.heliyon.2020.e05879

12. Rab family of small GTPases: an updated view on their regulation and functions

Author:
Homma, Yuta; Hiragi, Shu; Fukuda, Mitsunori
Source:
TheFEBS journal 2021 v.288 no.1 pp. 36-55
ISSN:
1742-464X
Subject:
phosphorylation,   etc   ; biogenesis; guanosinetriphosphatase; mammals; models; organelles;     Show all 6 Subjects
Abstract:
... The Rab family of small GTPases regulates intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound organelles and vesicles. Like other small GTPases, Rabs cycle between two states, an active (GTP‐loaded) state and an inactive (GDP‐loaded) state, and their cycling is catalyzed by guanine nucleotide exchange factors (GEFs) and GTPase‐acti ...
DOI:
10.1111/febs.15453

13. Regulation of histone deacetylase activities and functions by phosphorylation and its physiological relevance

Author:
Bahl, Sonali; Seto, Edward
Source:
Cellular and molecular life sciences 2021 v.78 no.2 pp. 427-445
ISSN:
1420-682X
Subject:
phosphorylation,   etc   ; ; histone deacetylase; histones; humans; lysine;     Show all 6 Subjects
Abstract:
... Histone deacetylases (HDACs) are conserved enzymes that regulate many cellular processes by catalyzing the removal of acetyl groups from lysine residues on histones and non-histone proteins. As appropriate for proteins that occupy such an essential biological role, HDAC activities and functions are in turn highly regulated. Overwhelming evidence suggests that the dysregulation of HDACs plays a maj ...
DOI:
10.1007/s00018-020-03599-4

14. Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction

Author:
Cao, Yuepeng; Gao, Zhenhua; Li, Junchen; Bi, Xiaojing; Yuan, Ling; Pei, Chengxin; Guo, Yongbiao; Shi, Enxue
Source:
RSC advances 2020 v.10 no.49 pp. 29493-29497
ISSN:
2046-2069
Subject:
phosphorylation,   etc   ; enols; regioselectivity;     Show all 3 Subjects
Abstract:
... A regioselective O/C phosphorylation of α-chloroketones with trialkyl phosphites was performed for the first time, which employed solvent-free Perkow reaction and NaI-assisted Arbuzov reaction under mild conditions respectively. Versatile enol phosphates were prepared in good to excellent yields as well as β-ketophosphinates. ...
DOI:
10.1039/d0ra05140c

15. Glycosylation is a novel TGFβ1-independent post-translational modification of Smad2

Author:
Gotoh, Takaya; Iwahana, Hiroyuki; Kannan, Surya; Marei, Reham Ghazal; Mousa, Hanaa; Elgamal, Mahmoud; Souchelnytskyi, Serhiy
Source:
Biochemical and biophysical research communications 2020 v.521 no.4 pp. 1010-1016
ISSN:
0006-291X
Subject:
phosphorylation,   etc   ; glycosylation; research;     Show all 3 Subjects
Abstract:
... Smad2 is a crucial component of intracellular signaling by transforming growth factor-β (TGFβ). Here we describe that Smad2 is glycosylated, which is a novel for Smad2 post-translational modification. We showed that the Smad2 glycosylation was inhibited upon treatment of cells with 17β-estradiol, and was enhanced in cells in a dense culture as compared to cells in a sparse culture. The Smad2 glyco ...
DOI:
10.1016/j.bbrc.2019.11.039

16. Intrinsically anti-flammable and self-toughened phosphorylated cardanol-derived novolac epoxy thermosets

Author:
Guo, Wenwen; Wang, Xin; Huang, Jiali; Cai, Wei; Song, Lei; Hu, Yuan
Source:
Industrial crops and products 2021 v.166 pp. 113496
ISSN:
0926-6690
Subject:
phosphorylation,   etc   ; brittleness; calorimeters; epoxidation reactions; epoxides; flammability; phosphates;     Show all 7 Subjects
Abstract:
... To overcome the flammability and brittleness of DGEBA, cardanol was selected to synthesize bio-based epoxy in this work because of its unique structure with both rigid aromatic rings and flexible long fatty chains. A novel intrinsically anti-flammable and self-toughened cardanol-derived novolac epoxy was synthesized through condensation, phosphorylation, and epoxidation processes, with a cardanol- ...
DOI:
10.1016/j.indcrop.2021.113496

17. Different co-culture models reveal the pivotal role of TBBPA-promoted M2 macrophage polarization in the deterioration of endometrial cancer

Author:
Jin, Xiaoting; Su, Huilan; Xu, Liting; Wang, Yu; Su, Ruijun; Zhang, Ze; Guan, Ge; Li, Zhuoyu
Source:
Journal of hazardous materials 2021 v.413 pp. 125337
ISSN:
0304-3894
Subject:
phosphorylation,   etc   ; biomarkers; coculture; humans; macrophages; phenotype; pollutants; uterine neoplasms;     Show all 8 Subjects
Abstract:
... Tetrabromobisphenol A (TBBPA), an emerging organic pollutant widely detected in human samples, has a positive correlation with the development of endometrial cancer (EC), but its underlying mechanisms have not yet been fully elucidated. Tumor-associated macrophages (TAM), one of the most vital components in tumor microenvironment (TME), play regulatory roles in the progression of EC. Consequently, ...
DOI:
10.1016/j.jhazmat.2021.125337

18. Chemical modifications and their effects on gluten protein: An extensive review

Author:
Abedi, E.; Pourmohammadi, K.
Source:
Food chemistry 2021 v.343 pp. 128398
ISSN:
0308-8146
Subject:
phosphorylation,   etc   ; acylation; deamidation; equipment; food chemistry; gluten; glycosylation; industry;     Show all 8 Subjects
Abstract:
... Gluten protein as one of the plant resources is susceptible to genetic, physical, chemical, enzymatic and engineering modifications. Chemical modifications have myriad advantages over other treatments, including short reaction times, low cost, no requirement for specialized equipment, and highly clear modification effects. Therefore, chemical modification of gluten can be mainly conducted via acyl ...
DOI:
10.1016/j.foodchem.2020.128398

19. CHYR1 ubiquitinates the phosphorylated WRKY70 for degradation to balance immunity in Arabidopsis thaliana

Author:
Liu, Huanhuan; Liu, Bao; Lou, Shangling; Bi, Hao; Tang, Hu; Tong, Shaofei; Song, Yan; Chen, Ningning; Zhang, Han; Jiang, Yuanzhong; Liu, Jianquan
Source:
Thenew phytologist 2021 v.230 no.3 pp. 1095-1109
ISSN:
0028-646X
Subject:
phosphorylation,   etc   ; Arabidopsis thaliana; genes; immunity; pathogens; proteasome endopeptidase complex;     Show all 6 Subjects
Abstract:
... It is critically important for plants to control the trade‐off between normal growth and pathogen immunity. However, the underlying molecular mechanism remains largely unknown. Here we report such a mechanism controlled by WRKY70 and its partner CHYR1 in Arabidopsis. We found that both levels of the WRKY70 target gene SARD1 and the phosphorylated forms of WRKY70 were increased in WRKY70OE plants u ...
DOI:
10.1111/nph.17231

20. Dual modification of various starches: Synthesis, properties and applications

Author:
Ashogbon, Adeleke Omodunbi
Source:
Food chemistry 2021 v.342 pp. 128325
ISSN:
0308-8146
Subject:
phosphorylation,   etc   ; acetylation; classification; extrusion; food chemistry; microwave treatment; synthesis;     Show all 7 Subjects
Abstract:
... The problems associated with native starches (NSs) and single modified starches were stated in order to justify dual modification of various starches. Broadly, there are two types of dual modification, i.e., homogeneous dual modification and heterogeneous dual modification. The combination of two physical modifications, e.g., (extrusion/annealing); two chemical modifications, e.g., (succinylation/ ...
DOI:
10.1016/j.foodchem.2020.128325