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1. Pore-Spanning Plasma Membranes Derived from Giant Plasma Membrane Vesicles

Author:
Teiwes, Nikolas K.; Mey, Ingo; Baumann, Phila C.; Strieker, Lena; Unkelbach, Ulla; Steinem, Claudia
Source:
ACS applied materials & interfaces 2021 v.13 no.22 pp. 25805-25812
ISSN:
1944-8252
Subject:
plasma membrane,   etc   ; cholesterol; fluorescence; separation; silicon;     Show all 5 Subjects
Abstract:
... Giant plasma membrane vesicles (GPMVs) are a highly promising model system for the eukaryotic plasma membrane. The unresolved challenge, however, is a path to surface-based structures that allows accessibility to both sides of the plasma membrane through high-resolution techniques. Such an approach would pave the way to advanced chip-based technologies for the analysis of complex cell surfaces to ...
DOI:
10.1021/acsami.1c06404

2. A guide to plasma membrane solute carrier proteins

Author:
Pizzagalli, Mattia D.; Bensimon, Ariel; Superti‐Furga, Giulio
Source:
TheFEBS journal 2021 v.288 no.9 pp. 2784-2835
ISSN:
1742-464X
Subject:
plasma membrane,   etc   ; humans; metabolism; organelles; solutes;     Show all 5 Subjects
Abstract:
... This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 families that carry a wide variety of substances across cellular membranes. While members of this superfamily are found throughout cellular organelles, this review focuses on transpo ...
DOI:
10.1111/febs.15531

3. Insights into cellular signaling from membrane dynamics

Author:
Sarkar, Parijat; Chattopadhyay, Amitabha
Source:
Archives of biochemistry and biophysics 2021 v.701 pp. 108794
ISSN:
0003-9861
Subject:
plasma membrane,   etc   ; biophysics; cell polarity; yeasts;     Show all 4 Subjects
Abstract:
... Biological membranes allow morphological compartmentalization of cells and represent complex micro-heterogeneous fluids exhibiting a range of dynamics. The plasma membrane occupies a central place in cellular signaling which allows the cell to perform a variety of functions. In this review, we analyze cellular signaling in a dynamic biophysical framework guided by the “mobile receptor hypothesis”. ...
DOI:
10.1016/j.abb.2021.108794

4. Dynamic spatial reorganization of BSK1 complexes in the plasma membrane underpins signal-specific activation for growth and immunity

Author:
Su, Bodan; Zhang, Xi; Li, Li; Abbas, Sammar; Yu, Meng; Cui, Yaning; Baluška, František; Hwang, Inhwan; Shan, Xiaoyi; Lin, Jinxing
Source:
Molecular plant 2021 v.14 no.4 pp. 588-603
ISSN:
1674-2052
Subject:
plasma membrane,   etc   ; dissociation; immunity; resource allocation;     Show all 4 Subjects
Abstract:
... Growth and immunity are opposing processes that compete for cellular resources, and proper resource allocation is crucial for plant survival. BSK1 plays a key role in the regulation of both growth and immunity by associating with BRI1 and FLS2, respectively. However, it remains unclear how two antagonistic signals co-opt BSK1 to induce signal-specific activation. Here we show that the dynamic spat ...
DOI:
10.1016/j.molp.2021.01.019

5. Cell-bound nanoparticles for tissue targeting and immunotherapy: Engineering of the particle–membrane interface

Author:
Prakash, Supriya; Kumbhojkar, Ninad; Clegg, John R.; Mitragotri, Samir
Source:
Current opinion in colloid & interface science 2021 v.52 pp. 101408
ISSN:
1359-0294
Subject:
plasma membrane,   etc   ; adhesion; drugs; immunotherapy; lipid composition;     Show all 5 Subjects
Abstract:
... Nanoparticles (NPs) have been developed as vehicles for delivering a variety of payloads including small molecules, nucleic acids, and proteins. To overcome the non-specific biodistribution of nanomaterials and target specific sites in vivo, there has been a surge of interest in using autologous cells as NP carriers. To design cell– NP constructs for active targeting, an understanding of the physi ...
DOI:
10.1016/j.cocis.2020.101408

6. KDEL receptor is a cell surface receptor that cycles between the plasma membrane and the Golgi via clathrin-mediated transport carriers

Author:
Jia, Jie; Yue, Xihua; Zhu, Lianhui; Jing, Shuaiyang; Wang, Yijing; Gim, Bopil; Qian, Yi; Lee, Intaek
Source:
Cellular and molecular life sciences 2021 v.78 no.3 pp. 1085-1100
ISSN:
1420-682X
Subject:
plasma membrane,   etc   ; endocytosis; endosomes; exports; protein transport;     Show all 5 Subjects
Abstract:
... KDEL receptor cycles between the ER and the Golgi to retrieve ER-resident chaperones that get leaked to the secretory pathway during protein export from the ER. Recent studies have shown that a fraction of KDEL receptor may reside in the plasma membrane and function as a putative cell surface receptor. However, the trafficking itinerary and mechanism of cell surface expressed KDEL receptor remains ...
DOI:
10.1007/s00018-020-03570-3

7. Model membrane systems to reconstitute immune cell signaling

Author:
Céspedes, Pablo F.; Beckers, Daniel; Dustin, Michael L.; Sezgin, Erdinc
Source:
TheFEBS journal 2021 v.288 no.4 pp. 1070-1090
ISSN:
1742-464X
Subject:
plasma membrane,   etc   ; biomimetics; chemical composition; immunological synapse;     Show all 4 Subjects
Abstract:
... Understanding the broad variety of functions encoded in cellular membranes requires experimental systems mimicking both their biochemical composition and biophysical properties. Here, we review the interplay between membrane components and the physical properties of the plasma membrane worth considering for biomimetic studies. Later, we discuss the main advantages and caveats of different model me ...
DOI:
10.1111/febs.15488

8. Studies on Ruellia tuberosa: A promising anti-fertility agent

Author:
Pardeshi, M. H.; Deshmukh, A. A.; Gajare, K.A.
Source:
BIOINFOLET 2021 v.18 no.1b pp. 185-188
ISSN:
0976-4755
Subject:
plasma membrane,   etc   ; Ruellia; albino; males; spermatozoa;     Show all 5 Subjects
Abstract:
... Present investigation was undertaken to determine anti-fertility of Ruellia tuberosa Linn. root powder in case of male albino mice.The results showed that the treatment of Ruellia tuberosa affects sperm plasma membrane which caused decreased sperm functions. ...

9. Simultaneous membrane binding of Annexin A4 and A5 suppresses 2D lattice formation while maintaining curvature induction

Author:
Mularski, Anna; Sønder, Stine Lauritzen; Heitmann, Anne Sofie Busk; Nylandsted, Jesper; Simonsen, Adam Cohen
Source:
Journal of colloid and interface science 2021 v.600 pp. 854-864
ISSN:
0021-9797
Subject:
plasma membrane,   etc   ; atomic force microscopy; calcium; fluorescence microscopy;     Show all 4 Subjects
Abstract:
... Annexin A4 and A5 (ANXA4, ANXA5), both shown to be required for efficient plasma membrane repair (PMR) in living cells, bind as trimers to anionic membranes in the presence of calcium. Both annexins induce membrane curvature and self-assemble into crystal arrays on membranes, observations that have been associated with PMR. However, in-vitro studies of annexins have traditionally been performed us ...
DOI:
10.1016/j.jcis.2021.05.067

10. Changes in structure and dimension of plasmodesmata in the phloem loading pathway in Tecoma capensis (Bignoniaceae) - locating the polymer trap

Author:
Botha, CEJ; Murugan, Nelisha
Source:
South African journal of botany 2021 v.140 pp. 76-86
ISSN:
0254-6299
Subject:
plasma membrane,   etc   ; Tecoma; mesophyll; plasmodesmata; raffinose; sucrose; ultrastructure;     Show all 7 Subjects
Abstract:
... Tecoma capensis is one of relatively few dicotyledonous plants in which the phloem in the veins of leaves, contain specialized parenchyma cells (called intermediary cells) in addition to sieve tubes and companion cells. These plants convert sucrose to the raffinose family oligosaccharides (RFOs), which form the primary transport sugar. The fact that the interface between bundle sheath and intermed ...
DOI:
10.1016/j.sajb.2021.03.032

11. Ubiquitin signalling: controlling the message of surface immune receptors

Author:
Trujillo, Marco
Source:
The new phytologist 2021 v.231 no.1 pp. 47-53
ISSN:
0028-646X
Subject:
plasma membrane,   etc   ; homeostasis; immune response; pathogens; protein degradation; proteome; ubiquitin;     Show all 7 Subjects
Abstract:
... Microbial attack is first detected by immune receptors located at the plasma membrane. Their activation triggers a plethora of signalling cascades that culminate in the immune response. Ubiquitin and ubiquitin‐like protein modifiers play key roles in controlling signalling amplitude and intensity, as well as in buffering proteome imbalances caused by pathogen attack. Here I highlight some of the i ...
DOI:
10.1111/nph.17360

12. The role and mechanism of β-arrestin2 in signal transduction

Author:
Ma, Tian-Liang; Zhou, Yong; Zhang, Chen-Yu; Gao, Zi-Ang; Duan, Jia-Xi
Source:
Life sciences 2021 v.275 pp. 119364
ISSN:
0024-3205
Subject:
plasma membrane,   etc   ; angiogenesis; autophagy; cytoplasm; scaffolding proteins; signal transduction; therapeutics;     Show all 7 Subjects
Abstract:
... β-arrestin2 is a ubiquitously expressed scaffold protein localized on the cytoplasm and plasma membrane. It was originally found to bind to GPCRs, uncoupling G proteins and receptors' binding and inhibiting the signal transduction of the GPCRs. Further investigations have revealed that β-arrestin2 not only mediates the desensitization of GPCRs but also serves as a multifunctional scaffold to media ...
DOI:
10.1016/j.lfs.2021.119364

13. Barbara G. Pickard - Queen of Plant Electrophysiology

Author:
Baluška, František; Mancuso, Stefano; Van Volkenburgh, Elizabeth
Source:
Plant signaling & behavior 2021 v.16 no.6 pp. 1911400
ISSN:
1559-2324
Subject:
plasma membrane,   etc   ; Barbara; auxins; behavior; models; neurons; phyllotaxy;     Show all 7 Subjects
Abstract:
... Barbara Gillespie Pickard (1936–2019) studied plant electrophysiology and mechanosensory biology for more than 50 y. Her first papers on the roles of auxin in plant tropisms were coauthored with Kenneth V. Thimann. Later, she studied plant electrophysiology. She made it clear that plant action potentials are not a peculiar feature of so-called sensitive plants, but that all plants exhibit these fa ...
DOI:
10.1080/15592324.2021.1911400

14. A transceptor–channel complex couples nitrate sensing to calcium signaling in Arabidopsis

Author:
Wang, Xiaohan; Feng, Changxin; Tian, LiLi; Hou, Congcong; Tian, Wang; Hu, Bin; Zhang, Qian; Ren, Zhijie; Niu, Qi; Song, Jiali; Kong, Dongdong; Liu, Liangyu; He, Yikun; Ma, Ligeng; Chu, Chengcai; Luan, Sheng; Li, Legong
Source:
Molecular plant 2021 v.14 no.5 pp. 774-786
ISSN:
1674-2052
Subject:
plasma membrane,   etc   ; Arabidopsis; calcium; mutants; nitrates; phenotype; root growth;     Show all 7 Subjects
Abstract:
... Nitrate-induced Ca²⁺ signaling is crucial for the primary nitrate response in plants. However, the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown. We report here that a cyclic nucleotide-gated channel (CNGC) protein, CNGC15, and the nitrate transceptor (NRT1.1) constitute a molecular switch that controls calcium influx depending on nitrate l ...
DOI:
10.1016/j.molp.2021.02.005

15. Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane

Author:
Maruoka, Masahiro; Zhang, Panpan; Mori, Hiromi; Imanishi, Eiichi; Packwood, Daniel M.; Harada, Hiroshi; Kosako, Hidetaka; Suzuki, Jun
Source:
Molecular cell 2021 v.81 no.7 pp. 1397-1410.e9
ISSN:
1097-2765
Subject:
plasma membrane,   etc   ; DNA repair; apoptosis; caspases; cytoplasm; phosphatidylserines;     Show all 6 Subjects
Abstract:
... Phospholipid scrambling in dying cells promotes phosphatidylserine exposure, a critical process for efferocytosis. We previously identified the Xkr family protein Xkr4 as a phospholipid-scrambling protein, but its activation mechanisms remain unknown. Here we show that Xkr4 is activated in two steps: dimer formation by caspase-mediated cleavage and structural change caused by activating factors. T ...
DOI:
10.1016/j.molcel.2021.02.025

16. Apical-basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes

Author:
Heiden, Stefanie; Siwek, Rebecca; Lotz, Marie-Luise; Borkowsky, Sarah; Schröter, Rita; Nedvetsky, Pavel; Rohlmann, Astrid; Missler, Markus; Krahn, Michael P.
Source:
Cellular and molecular life sciences 2021 v.78 no.7 pp. 3657-3672
ISSN:
1420-682X
Subject:
plasma membrane,   etc   ; Drosophila; cortex; diaphragm; endocytosis; epithelium; filtration; mammals; microscopy;     Show all 9 Subjects
Abstract:
... Apical-basal polarity is a key feature of most epithelial cells and it is regulated by highly conserved protein complexes. In mammalian podocytes, which emerge from columnar epithelial cells, this polarity is preserved and the tight junctions are converted to the slit diaphragms, establishing the filtration barrier. In Drosophila, nephrocytes show several structural and functional similarities wit ...
DOI:
10.1007/s00018-021-03769-y

17. The cytoskeleton influences the formation and distribution of eisosomes in Neurospora crassa

Author:
Yang, Qin
Source:
Biochemical and biophysical research communications 2021 v.545 pp. 62-68
ISSN:
0006-291X
Subject:
plasma membrane,   etc   ; Neurospora crassa; actin; benomyl; conidia; hyphae; microtubules; research;     Show all 8 Subjects
Abstract:
... Eisosomes are stable protein complexes at the plasma membrane, with punctate distributional patterns. Their formation and how their locations are determined remain unclear. The current study discovered that the formation and distribution of eisosomes are influenced by the cytoskeleton. Disassembly of either the F-actin or the microtubules leads to eisosome localization at hyphal tips of germinated ...
DOI:
10.1016/j.bbrc.2021.01.037

18. Construction of fluorescent rotors with multiple intramolecular rotation sites for visualization of cellular viscous compartments with elevated fidelity

Author:
Hao, Qiuhua; Li, Chuanya; Niu, Jie; Yang, Rui; Yu, Xiaoqiang
Source:
Analytical methods 2021 v.13 no.9 pp. 1132-1137
ISSN:
1759-9679
Subject:
plasma membrane,   etc   ; bioimaging; fluorescence; liver; mitochondria; myocardium; skeletal muscle; viscosity;     Show all 8 Subjects
Abstract:
... Viscosity-sensitive fluorescent dyes are widely utilized to image viscous intracellular compartments with high fidelity. However, the sensitivity of many fluorescent rotors needs improvement for bioimaging applications. Herein, we proposed to construct a fluorescent rotor with multiple intramolecular rotation sites to elevate its sensitivity to environmental viscosity. The fabricated fluorescent r ...
DOI:
10.1039/d0ay02247k

19. Rapid Enzyme-Mediated Biotinylation for Cell Surface Proteome Profiling

Author:
Li, Yanan; Wang, Yan; Yao, Yating; Lyu, Jiawen; Qiao, Qinglong; Mao, Jiawei; Xu, Zhaochao; Ye, Mingliang
Source:
Analytical chemistry 2021 v.93 no.10 pp. 4542-4551
ISSN:
1520-6882
Subject:
plasma membrane,   etc   ; analytical chemistry; biotinylation; insulin; phenotype; proteome; proteomics; tyrosine;     Show all 8 Subjects
Abstract:
... Cell surface is the primary site for sensing extracellular stimuli. The knowledge of the transient changes on the surfaceome upon a perturbation is very important as the initial changed proteins could be driving molecules for some phenotype. In this study, we report a fast cell surface labeling strategy based on peroxidase-mediated oxidative tyrosine coupling strategy, enabling efficient and selec ...
DOI:
10.1021/acs.analchem.0c04970

20. Producing Cd-safe rice grains in moderately and seriously Cd-contaminated paddy soils

Author:
Chen, Hong-Ping; Wang, Peng; Chang, Jia-Dong; Kopittke, Peter M.; Zhao, Fang-Jie
Source:
Chemosphere 2021 v.267 pp. 128893
ISSN:
0045-6535
Subject:
plasma membrane,   etc   ; biomass; cadmium; pH; paddies; rice; tonoplast; water management;     Show all 8 Subjects
Abstract:
... Rice grains produced on cadmium (Cd) contaminated paddy soils often exceed the maximum permissible limit. A number of mitigation methods have been proposed to decrease Cd accumulation in rice grain in contaminated acidic soils, including altering water management regimes, liming, and genetic engineering. In the present study, we conducted a pot experiment to compare these methods for their effecti ...
DOI:
10.1016/j.chemosphere.2020.128893