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1. Receptor‐Free Signaling at Curved Cellular Membranes

Author:
Ebrahimkutty, Mirsana P.; Galic, Milos
Source:
BioEssays 2019 v.41 no.10 pp. e1900068
ISSN:
0265-9247
Subject:
plasma membrane,   etc   ; deformation; geometry;     Show all 3 Subjects
Abstract:
... Plasma membranes are subject to continuous deformations. Strikingly, some of these transient membrane undulations yield membrane‐associated signaling hubs that differ in composition and function, depending on membrane geometry and the availability of co‐factors. Here, recent advancements on this ubiquitous type of receptor‐independent signaling are reviewed, with a special focus on emerging concep ...
DOI:
10.1002/bies.201900068

2. Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers

Author:
Hobbs, G. Aaron; Der, Channing J.
Source:
Trends in biochemical sciences 2020 v.45 no.6 pp. 459-461
ISSN:
0968-0004
Subject:
plasma membrane,   etc   ; H-transporting ATP synthase; binging; neoplasms; oncogene proteins;     Show all 5 Subjects
Abstract:
... The RAS oncoprotein drives elevated macropinocytosis, a metabolic process essential for cancer growth. A recent study by Ramirez et al. elucidated a mechanism whereby RAS controls V-ATPase association with the plasma membrane to drive RAC1 GTPase-dependent macropinocytosis. Potentially actionable targets to disrupt this RAS-dependent nutrient acquisition pathway were identified. ...
DOI:
10.1016/j.tibs.2020.02.009

3. The Golgi as an Assembly Line to the Autophagosome

Author:
De Tito, Stefano; Hervás, Javier H.; van Vliet, Alexander R.; Tooze, Sharon A.
Source:
Trends in biochemical sciences 2020 v.45 no.6 pp. 484-496
ISSN:
0968-0004
Subject:
plasma membrane,   etc   ; Golgi apparatus; autophagosomes; autophagy; endoplasmic reticulum; lipids; proteins;     Show all 7 Subjects
Abstract:
... Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular cargo. However, recent studies have identified myriad pathways and cellular organelles underlying the autophagy process, be it as signaling platforms or through the contribution of proteins and lipids. The Golgi complex is recognized as being a central transport hu ...
DOI:
10.1016/j.tibs.2020.03.010

4. How a lipid bilayer membrane responds to an oscillating nanoparticle: Promoted membrane undulation and directional wave propagation

Author:
Li, Shixin; Yan, Zengshuai; Huang, Fang; Zhang, Xianren; Yue, Tongtao
Source:
Colloids and surfaces 2020 v.187 pp. 110651
ISSN:
0927-7765
Subject:
plasma membrane,   etc   ; energy; forces; lipid bilayers; nanoparticles; surface tension;     Show all 6 Subjects
Abstract:
... Mechanical forces acting on a plasma membrane are of essential importance to cellular functioning via inducing delicate change of the membrane shape with the underlying mechanism yet to be elucidated. Here, we introduce an oscillating nanoparticle (NP) interaction with a lipid bilayer membrane, using the coarse-grained simulation to investigate the dynamic membrane response to constrained mechanic ...
DOI:
10.1016/j.colsurfb.2019.110651

5. The diffusive injection micropipette (DIMP)

Author:
Howell, Alexander H.; Peters, Winfried S.; Knoblauch, Michael
Source:
Journal of plant physiology 2020 v.244 pp. 153060
ISSN:
0176-1617
Subject:
plasma membrane,   etc   ; Nicotiana; cell walls; equipment; fluorescent dyes; fungi; trichomes;     Show all 7 Subjects
Abstract:
... The microinjection of fluorescent probes into live cells is an essential component in the toolbox of modern cell biology. Microinjection techniques include the penetration of the plasma membrane and, if present, the cell wall with micropipettes, and the application of pressure or electrical currents to drive the micropipette contents into the cell. These procedures interfere with cellular function ...
DOI:
10.1016/j.jplph.2019.153060

6. Tools for Understanding Nanoscale Lipid Regulation of Ion Channels

Author:
Robinson, Carol V.; Rohacs, Tibor; Hansen, Scott B.
Source:
Trends in biochemical sciences 2019 v.44 no.9 pp. 795-806
ISSN:
0968-0004
Subject:
plasma membrane,   etc   ; ion channels; phospholipids;     Show all 3 Subjects
Abstract:
... Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartm ...
DOI:
10.1016/j.tibs.2019.04.001
PubMed:
31060927
PubMed Central:
PMC6729126

7. An improved protein lipid overlay assay for studying lipid–protein interactions

Author:
Han, Xiuli; Yang, Yongqing; Zhao, Fengyun; Zhang, Tianren; Yu, Xiang
Source:
Plant methods 2020 v.16 no.1 pp. 33
ISSN:
1746-4811
Subject:
plasma membrane,   etc   ; Arabidopsis; H-transporting ATP synthase; binding proteins; metabolism; phosphatidylserines;     Show all 6 Subjects
Abstract:
... BACKGROUND: Lipids perform multiple functions in the cell, and lipid–protein interactions play a key role in metabolism. Although various techniques have been developed to study lipid–protein interactions, the interacting protein partners that bind to most lipids remain unknown. The protein lipid overlay (PLO) assay has revealed numerous lipid–protein interactions, but its application suffers from ...
DOI:
10.1186/s13007-020-00578-5
PubMed:
32165912
PubMed Central:
PMC7060618

8. Analysis of the expression of transglutaminases in the reconstructed human epidermis using a three-dimensional cell culture

Author:
Teshima, Hirofumi; Kato, Manami; Tatsukawa, Hideki; Hitomi, Kiyotaka
Source:
Analytical biochemistry 2020 v.603 pp. 113606
ISSN:
0003-2697
Subject:
plasma membrane,   etc   ; artificial skin; catalytic activity; cell culture; crosslinking; enzymes; keratinocytes; peptides; structural proteins;     Show all 9 Subjects
Abstract:
... The skin epidermis functions as a barrier to various external stresses. In the outermost layer, the terminally differentiated keratinocytes result in cornification with a tough structure by formation of a cornified envelope beneath the plasma membrane. To complete the formation of the cornified envelope, several structural proteins are cross-linked via the catalytic action of transglutaminases (TG ...
DOI:
10.1016/j.ab.2020.113606

9. ESCRT-I Component VPS23A Sustains Salt Tolerance by Strengthening the SOS Module in Arabidopsis

Author:
Lou, Lijuan; Yu, Feifei; Tian, Miaomiao; Liu, Guangchao; Wu, Yaorong; Wu, Yujiao; Xia, Ran; Pardo, Jose M.; Guo, Yan; Xie, Qi
Source:
Molecular plant 2020 v.13 no.8 pp. 1134-1148
ISSN:
1674-2052
Subject:
plasma membrane,   etc   ; Arabidopsis; antiporters; excretion; gene overexpression; regulatory proteins; salt stress; salt tolerance; seedlings; sodium;     Show all 10 Subjects
Abstract:
... The Salt-Overly-Sensitive (SOS) signaling module, comprising the sodium-transport protein SOS1 and the regulatory proteins SOS2 and SOS3, is well known as the central salt excretion system, which helps protect plants against salt stress. Here we report that VPS23A, a component of the ESCRT (endosomal sorting complex required for transport), plays an essential role in the function of the SOS module ...
DOI:
10.1016/j.molp.2020.05.010

10. Dual Function of PI(4,5)P2 in Insulin-Regulated Exocytic Trafficking of GLUT4 in Adipocytes

Author:
Li, Hanbing; Shentu, Ping; Xiao, Mei; Zhao, Xuqin; Fan, Jiannan; Liu, Xuechun; Lin, Yinyan; Wang, Lei; Li, Hong; Guo, Xiaogang; Idevall-Hagren, Olof; Xu, Yingke
Source:
Journal of molecular biology 2020 v.432 no.16 pp. 4341-4357
ISSN:
0022-2836
Subject:
plasma membrane,   etc   ; adipocytes; glucose transporters; image analysis; insulin; metabolism; optogenetics; phosphorylation;     Show all 8 Subjects
Abstract:
... Phosphoinositides are important signaling molecules involved in the regulation of vesicular trafficking. It has been implicated that phosphatidylinositol 4,5-bisphosphate [PI(4,5)P₂] is involved in insulin-regulated GLUT4 translocation in adipocytes. However, it remains unclear where and how PI(4,5)P₂ regulates discrete steps of GLUT4 vesicle translocation in adipocytes, especially on the exocytic ...
DOI:
10.1016/j.jmb.2020.06.019

11. Radio-frequency dielectric relaxation behavior of selected vegetable tissues: Spectra analysis with logarithmic derivative method and simulation with double-shell model

Author:
Li, Ying; Han, Mingjuan; Zhou, Wei; Chen, Zhen
Source:
Journal of food engineering 2020 v.277 pp. 109914
ISSN:
0260-8774
Subject:
plasma membrane,   etc   ; protoplasm; radio waves; sap; simulation models; tissues; tonoplast; vegetables;     Show all 8 Subjects
Abstract:
... The dielectric relaxation behaviors in the radio-frequency range, where β- relaxation is predominant, of flesh tissues of several vegetables are studied in this work. By taking advantage of the logarithmic derivative method, three sub -β- relaxations were revealed for all vegetable tissues under study, and their relaxation characteristics were accurately determined. The relaxation behaviors were f ...
DOI:
10.1016/j.jfoodeng.2020.109914

12. Membrane Lipid Requirements of the Lysine Transporter Lyp1 from Saccharomyces cerevisiae

Author:
van 't Klooster, Joury S.; Cheng, Tan-Yun; Sikkema, Hendrik R.; Jeucken, Aike; Moody, D. Branch; Poolman, Bert
Source:
Journal of molecular biology 2020 v.432 no.14 pp. 4023-4031
ISSN:
0022-2836
Subject:
plasma membrane,   etc   ; Saccharomyces cerevisiae; ergosterol; lipid composition; lysine; membrane proteins; models; permeability; phosphatidylserines; prediction; solvents; yeasts;     Show all 12 Subjects
Abstract:
... Membrane lipids act as solvents and functional cofactors for integral membrane proteins. The yeast plasma membrane is unusual in that it may have a high lipid order, which coincides with low passive permeability for small molecules and a slow lateral diffusion of proteins. Yet, membrane proteins whose functions require altered conformation must have flexibility within membranes. We have determined ...
DOI:
10.1016/j.jmb.2020.04.029

13. A PI4KIIIα protein complex is required for cell viability during Drosophila wing development

Author:
Basu, Urbashi; Balakrishnan, Sruthi S.; Janardan, Vishnu; Raghu, Padinjat
Source:
Developmental biology 2020 v.462 no.2 pp. 208-222
ISSN:
0012-1606
Subject:
plasma membrane,   etc   ; 1-phosphatidylinositol 4-kinase; Drosophila; apoptosis; caspases; cell viability; metabolites; phosphates;     Show all 8 Subjects
Abstract:
... Phosphatidylinositol 4 phosphate (PI4P) and phosphatidylinositol 4,5 bisphosphate [PI(4,5)P₂] are enriched on the inner leaflet of the plasma membrane and proposed to be key determinants of its function. PI4P is also the biochemical precursor for the synthesis of PI(4,5)P₂ but can itself also bind to and regulate protein function. However, the independent function of PI4P at the plasma membrane in ...
DOI:
10.1016/j.ydbio.2020.03.008

14. Structural Basis Underlying Strong Interactions between Ankyrins and Spectrins

Author:
Li, Jianchao; Chen, Keyu; Zhu, Ruichi; Zhang, Mingjie
Source:
Journal of molecular biology 2020 v.432 no.13 pp. 3838-3850
ISSN:
0022-2836
Subject:
plasma membrane,   etc   ; ankyrins; blood plasma; erythrocytes; microfilaments; myocytes; neurons; spectrin; strength (mechanics);     Show all 9 Subjects
Abstract:
... Ankyrins (encoded by ANK1/2/3 corresponding to Ankyrin-R/B/G or AnkR/B/G), via binding to spectrins, connect plasma membranes with actin cytoskeleton to maintain mechanical strengths and to modulate excitabilities of diverse cells such as neurons, muscle cells, and erythrocytes. Cellular and genetic evidences suggest that each isoform of ankyrins pairs with a specific β-spectrin in discrete subcel ...
DOI:
10.1016/j.jmb.2020.04.023

15. Synthesis and Function of Complex Sphingolipid Glycosylation

Author:
Mortimer, Jenny C.; Scheller, Henrik Vibe
Source:
Trends in plant science 2020 v.25 no.6 pp. 522-524
ISSN:
1360-1385
Subject:
plasma membrane,   etc   ; abiotic stress; glycosylation; microsymbionts; plant development; sphingolipids; stress tolerance; tissues;     Show all 8 Subjects
Abstract:
... Glycosylinositol phosphorylceramides (GIPCs) constitute an important class of plasma-membrane lipids in plants. The complex glycan headgroups of GIPCs vary between plant species and tissues. Recent studies have shown that the structure of the glycan headgroup is important for plant development, abiotic stress tolerance, and interactions with pathogenic and symbiotic microorganisms. ...
DOI:
10.1016/j.tplants.2020.03.007

16. The CBL–CIPK Calcium Signaling Network: Unified Paradigm from 20 Years of Discoveries

Author:
Tang, Ren-Jie; Wang, Chao; Li, Kunlun; Luan, Sheng
Source:
Trends in plant science 2020 v.25 no.6 pp. 604-617
ISSN:
1360-1385
Subject:
plasma membrane,   etc   ; abiotic stress; calcium; calcium signaling; eukaryotic cells; protein kinases; tonoplast; transporters;     Show all 8 Subjects
Abstract:
... Calcium (Ca²⁺) serves as an essential nutrient as well as a signaling agent in all eukaryotes. In plants, calcineurin B-like proteins (CBLs) are a unique group of Ca²⁺ sensors that decode Ca²⁺ signals by activating a family of plant-specific protein kinases known as CBL-interacting protein kinases (CIPKs). Interactions between CBLs and CIPKs constitute a signaling network that enables information ...
DOI:
10.1016/j.tplants.2020.01.009

17. All Roads Lead to Auxin: Post-translational Regulation of Auxin Transport by Multiple Hormonal Pathways

Author:
Semeradova, Hana; Montesinos, Juan Carlos; Benkova, Eva
Source:
Plant communications 2020 v.1 no.3 pp. 100048
ISSN:
2590-3462
Subject:
plasma membrane,   etc   ; auxins; growth and development; hormones; physiological transport; plant development; plant growth; plant organs; transporters;     Show all 9 Subjects
Abstract:
... Auxin is a key hormonal regulator, that governs plant growth and development in concert with other hormonal pathways. The unique feature of auxin is its polar, cell-to-cell transport that leads to the formation of local auxin maxima and gradients, which coordinate initiation and patterning of plant organs. The molecular machinery mediating polar auxin transport is one of the important points of in ...
DOI:
10.1016/j.xplc.2020.100048

18. Imaging the fibroblast growth factor receptor network on the plasma membrane with DNA-assisted single-molecule super-resolution microscopy

Author:
Schröder, Mark S.; Harwardt, Marie-Lena I.E.; Rahm, Johanna V.; Li, Yunqing; Freund, Petra; Dietz, Marina S.; Heilemann, Mike
Source:
Methods 2020
ISSN:
1046-2023
Subject:
plasma membrane,   etc   ; antibodies; fibroblast growth factor receptors; image analysis; ligands; membrane proteins; microscopy; protein content;     Show all 8 Subjects
Abstract:
... Fibroblast growth factor receptors (FGFRs) are a subfamily of receptor tyrosine kinases and central players in health and disease. Following ligand binding and the formation of homo- and heteromeric complexes, FGFRs initiate a cellular response. Challenges in studying FGFR activation are inner-subfamily interactions and a complex heterogeneity of these in the cell membrane, which demand for observ ...
DOI:
10.1016/j.ymeth.2020.05.004

19. Correlating single-molecule characteristics of the yeast aquaglyceroporin Fps1 with environmental perturbations directly in living cells

Author:
Shashkova, Sviatlana; Andersson, Mikael; Hohmann, Stefan; Leake, Mark C.
Source:
Methods 2020
ISSN:
1046-2023
Subject:
plasma membrane,   etc   ; Saccharomyces cerevisiae; fluorescence microscopy; hydrogen peroxide; membrane proteins; oxidative stress; stoichiometry; yeasts;     Show all 8 Subjects
Abstract:
... Membrane proteins play key roles at the interface between the cell and its environment by mediating selective import and export of molecules via plasma membrane channels. Despite a multitude of studies on transmembrane channels, understanding of their dynamics directly within living systems is limited. To address this, we correlated molecular scale information from living cells with real time chan ...
DOI:
10.1016/j.ymeth.2020.05.003

20. TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway in Higher Plants

Author:
Moulinier-Anzola, Jeanette; Schwihla, Maximilian; De-Araújo, Lucinda; Artner, Christina; Jörg, Lisa; Konstantinova, Nataliia; Luschnig, Christian; Korbei, Barbara
Source:
Molecular plant 2020 v.13 no.5 pp. 717-731
ISSN:
1674-2052
Subject:
plasma membrane,   etc   ; environmental factors; mutation; plant development; receptors; ubiquitin; ubiquitination; vacuoles;     Show all 8 Subjects
Abstract:
... Protein abundance and localization at the plasma membrane (PM) shapes plant development and mediates adaptation to changing environmental conditions. It is regulated by ubiquitination, a post-translational modification crucial for the proper sorting of endocytosed PM proteins to the vacuole for subsequent degradation. To understand the significance and the variety of roles played by this reversibl ...
DOI:
10.1016/j.molp.2020.02.012