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You searched for: Subject "plasma membrane" Remove constraint Subject: "plasma membrane"
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1. Tiki proteins are glycosylphosphatidylinositol‐anchored proteases

Author:
Mingyi Li; Jing Zheng; Xi He; Xinjun Zhang
Source:
FEBS letters 2022 v.596 no.8 pp. 1037-1046
ISSN:
0014-5793
Subject:
plasma membrane,   etc   ; homeostasis; humans; proteinases;     Show all 4 Subjects
Abstract:
... Wnt signalling pathways play pivotal roles in development, homeostasis and human diseases, and are tightly regulated. We previously identified Tiki as a novel family of Wnt inhibitory proteases. Tiki proteins were predicted as type I transmembrane proteins and can act in both Wnt‐producing and Wnt‐responsive cells. Here, we characterize Tiki proteins as glycosylphosphatidylinositol (GPI)‐anchored ...
DOI:
10.1002/1873-3468.14320

2. The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism

Author:
Barbara Ann Halkier; Deyang Xu
Source:
Natural product reports 2022 v.39 no.7 pp. 1483-1491
ISSN:
1460-4752
Subject:
plasma membrane,   etc   ; metabolism; metabolites; tonoplast;     Show all 4 Subjects
Abstract:
... Plants are organic chemists par excellence and produce an amazing array of diverse chemical structures. Whereas primary metabolites are essential for all living organisms and highly conserved, the specialized metabolites constitute the taxonomy-specific chemical languages that are key for fitness and survival. Allocation of plants' wide array of specialized metabolites in patterns that are fine-tu ...
DOI:
10.1039/d2np00016d

3. Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells

Author:
Susav Pradhan; Martin A.K. Williams; Tracy K. Hale
Source:
Biochemical and biophysical research communications 2022 v.587 pp. 126-130
ISSN:
0006-291X
Subject:
plasma membrane,   etc   ; breast neoplasms; research;     Show all 3 Subjects
Abstract:
... Plasma membrane tension is known to regulate many cell functions, such as motility and membrane trafficking. Membrane tether pulling is an effective method for measuring the apparent membrane tension of cells and exploring membrane-cytoskeleton interactions. In this article, the mechanical properties of HP1α-depleted MCF7 breast cancer cells are explored in comparison to controls, by pulling membr ...
DOI:
10.1016/j.bbrc.2021.11.081

4. Recent developments in the understanding of PIN polarity

Author:
Petra Marhava
Source:
The new phytologist 2022 v.233 no.2 pp. 624-630
ISSN:
0028-646X
Subject:
plasma membrane,   etc   ; auxins; plant development; plant hormones;     Show all 4 Subjects
Abstract:
... Polar localization of PIN‐FORMED proteins (PINs) at the plasma membrane is essential for plant development as they direct the transport of phytohormone auxin between cells. PIN polar localization to certain sides of a given cell is dynamic, strictly regulated and provides directionality to auxin flow. Signals that act upstream to control subcellular PIN localization modulate auxin distribution, th ...
DOI:
10.1111/nph.17867

5. Relationship between HIV-1 Gag Multimerization and Membrane Binding

Author:
Christopher Sumner; Akira Ono
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
plasma membrane,   etc   ; phospholipids; polyproteins; virion; virus assembly;     Show all 5 Subjects
Abstract:
... HIV-1 viral particle assembly occurs specifically at the plasma membrane and is driven primarily by the viral polyprotein Gag. Selective association of Gag with the plasma membrane is a key step in the viral assembly pathway, which is traditionally attributed to the MA domain. MA regulates specific plasma membrane binding through two primary mechanisms including: (1) specific interaction of the MA ...
DOI:
10.3390/v14030622

6. The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates

Author:
Mikhail Matveyenka; Stanislav Rizevsky; Dmitry Kurouski
Source:
FEBS letters 2022 v.596 no.11 pp. 1424-1433
ISSN:
0014-5793
Subject:
plasma membrane,   etc   ; amyloid; apoptosis; cytotoxicity; insulin; phosphatidylserines;     Show all 6 Subjects
Abstract:
... Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies that are associated with aggregation of misfolded proteins. In this work, we examine the effect of both saturated PS (DMPS) and unsaturated PS (DOPS and POPS) on the aggregation properties of insulin, as well as the struc ...
DOI:
10.1002/1873-3468.14369

7. The roles of transmembrane family proteins in the regulation of store-operated Ca2+ entry

Author:
Ningxia Zhang; Hongming Pan; Xiaojing Liang; Jiansheng Xie; Weidong Han
Source:
Cellular and molecular life sciences 2022 v.79 no.2 pp. 118
ISSN:
1420-682X
Subject:
plasma membrane,   etc   ; calcium; cell proliferation; death; organelles;     Show all 5 Subjects
Abstract:
... Store-operated Ca²⁺ entry (SOCE) is a major pathway for calcium signaling, which regulates almost every biological process, involving cell proliferation, differentiation, movement and death. Stromal interaction molecule (STIM) and ORAI calcium release-activated calcium modulator (ORAI) are the two major proteins involved in SOCE. With the deepening of studies, more and more proteins are found to b ...
DOI:
10.1007/s00018-021-04034-y

8. Regulators regulated: Different layers of control for plasma membrane phosphoinositides in plants

Author:
Mareike Heilmann; Ingo Heilmann
Source:
Current opinion in plant biology 2022 v.67 pp. 102218
ISSN:
1369-5266
Subject:
plasma membrane,   etc   ; biogenesis; cytoskeleton; plant tissues; transcription (genetics);     Show all 5 Subjects
Abstract:
... The membranes of plant cells serve diverse physiological roles, which are defined largely by the localized and dynamic recruitment of proteins. Signaling lipids, such as phosphoinositides, can aid protein recruitment to the plasma membrane via specific recognition of their head groups and influence vesicular trafficking, cytoskeletal dynamics and other processes, with ramifications for plant tissu ...
DOI:
10.1016/j.pbi.2022.102218

9. Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells

Author:
Jose Sanchez-Collado; Jose J. Lopez; Isaac Jardin; Alejandro Berna-Erro; Pedro J. Camello; Carlos Cantonero; Tarik Smani; Gines M. Salido; Juan A. Rosado
Source:
Cellular and molecular life sciences 2022 v.79 no.1 pp. 33
ISSN:
1420-682X
Subject:
plasma membrane,   etc   ; agonists; calcium; fluorescence; mammals; precipitin tests;     Show all 6 Subjects
Abstract:
... The identification of two variants of the canonical pore-forming subunit of the Ca²⁺ release-activated Ca²⁺ (CRAC) channel Orai1, Orai1α and Orai1β, in mammalian cells arises the question whether they exhibit different functional characteristics. Orai1α and Orai1β differ in the N-terminal 63 amino acids, exclusive of Orai1α, and show different sensitivities to Ca²⁺-dependent inactivation, as well ...
DOI:
10.1007/s00018-021-04098-w

10. Focus on ferroptosis regulation: Exploring novel mechanisms and applications of ferroptosis regulator

Author:
Tian-Liang Ma; Jing-Xian Chen; Peng Zhu; Chao-Bin Zhang; Yong Zhou; Jia-Xi Duan
Source:
Life sciences 2022 v.307 pp. 120868
ISSN:
0024-3205
Subject:
plasma membrane,   etc   ; ferroptosis; iron; lipid peroxidation; mitochondria; necrosis; toxicity;     Show all 7 Subjects
Abstract:
... Ferroptosis is a kind of iron-dependent regulatory necrosis characterized by the fatal accumulation of iron-dependent lipid peroxides in the plasma membrane and the final oxidative damage of the cell membrane. Morphologically, ferroptosis features high membrane density, decreased or disappeared cristae, rupture of the mitochondrial outer membrane, plasma membrane integrity loss, cytoplasmic swelli ...
DOI:
10.1016/j.lfs.2022.120868

11. Phytophthora infestans Ago1‐associated miRNA promotes potato late blight disease

Author:
Xinyi Hu; Kristian Persson Hodén; Zhen Liao; Anna Åsman; Christina Dixelius
Source:
The new phytologist 2022 v.233 no.1 pp. 443-457
ISSN:
0028-646X
Subject:
plasma membrane,   etc   ; Phytophthora infestans; biogenesis; genes; leaves; microRNA; potatoes;     Show all 7 Subjects
Abstract:
... Phytophthora spp. cause serious damage to plants by exploiting a large number of effector proteins and small RNAs (sRNAs). Several reports have described modulation of host RNA biogenesis and defence gene expression. Here, we analysed Phytophthora infestans Argonaute (Ago) 1 associated small RNAs during potato leaf infection. Small RNAs were co‐immunoprecipitated, deep sequenced and analysed again ...
DOI:
10.1111/nph.17758

12. Tip-end fusion of a rod-shaped secretory organelle

Author:
Johannes Naß; Sophia N. Koerdt; Anja Biesemann; Tarek Chehab; Takao Yasuda; Mitsunori Fukuda; Fernando Martín-Belmonte; Volker Gerke
Source:
Cellular and molecular life sciences 2022 v.79 no.6 pp. 344
ISSN:
1420-682X
Subject:
plasma membrane,   etc   ; actin; exocytosis; membrane fusion; organelles; secretion; topology;     Show all 7 Subjects
Abstract:
... Weibel–Palade bodies (WPB) are elongated, rod-like secretory organelles unique to endothelial cells that store the pro-coagulant von-Willebrand factor (VWF) and undergo regulated exocytosis upon stimulation with Ca²⁺- or cAMP-raising agonists. We show here that WPB preferentially initiate fusion with the plasma membrane at their tips and identify synaptotagmin-like protein 2-a (Slp2-a) as a positi ...
DOI:
10.1007/s00018-022-04367-2

13. The yin and yang of intracellular delivery of amphipathic optical probes using n-butyl charge masking

Author:
Hitesh K. Agarwal; Radoslav Janicek; Jun Zhao; Karthik Sambath; Marcel Egger; Ernst Niggli; Graham C. R. Ellis-Davies
Source:
Chemical communications 2022 v.58 no.17 pp. 2826-2829
ISSN:
1364-548X
Subject:
plasma membrane,   etc   ; calcium; cell physiology; cytosol; esterases; ionization; surfactants;     Show all 7 Subjects
Abstract:
... Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have multiple negative charges, they must be smuggled through the plasma membrane in a transiently neutral form, with intracellular esterases used to deprotect the masked anions. Here we e ...
DOI:
10.1039/d1cc06792c

14. Con‐Ca2+‐tenating plant immune responses via calcium‐permeable cation channels

Author:
Nak Hyun Kim; Pierre Jacob; Jeffery L. Dangl
Source:
The new phytologist 2022 v.234 no.3 pp. 813-818
ISSN:
0028-646X
Subject:
plasma membrane,   etc   ; apoplast; calcium; cations; cytoplasm; immune system; pathogens;     Show all 7 Subjects
Abstract:
... Calcium serves as a second messenger in a variety of developmental and physiological processes and has long been identified as important for plant immune responses. We discuss recent discoveries regarding plant immune‐related calcium‐permeable channels and how the two intertwined branches of the plant immune system are intricately linked to one another through calcium signalling. Cell surface immu ...
DOI:
10.1111/nph.18044

15. Recruitment of TNF ligands to lipid rafts is mediated by their physical association with caveolin‐1

Author:
Xenia A. Glukhova; Julia A. Trizna; Bogdan S. Melnik; Olga V. Proussakova; Igor P. Beletsky
Source:
FEBS letters 2022 v.596 no.2 pp. 211-218
ISSN:
0014-5793
Subject:
plasma membrane,   etc   ; ligands; lipids; necrosis; neoplasms; tumor necrosis factors;     Show all 6 Subjects
Abstract:
... Activities of the tumour necrosis factor (TNF) family members are associated with their targeting to lipid rafts, specialised regions of the plasma membrane. Herein, we investigated the physical association of TNF and its family members cluster of differentiation 40 ligand (CD40L) and tumour necrosis factor‐related apoptosis‐inducing ligand with caveolin‐1, a lipid raft resident protein. We discov ...
DOI:
10.1002/1873-3468.14257

16. Development of a direct point electron beam exposure system to investigate the biological functions of subcellular domains in a living biological cell

Author:
Asahi Tanaka; Wataru Inami; Yuko Suzuki; Yoshimasa Kawata
Source:
Micron 2022 v.155 pp. 103214
ISSN:
0968-4328
Subject:
plasma membrane,   etc   ; calcium; electron microscopy; films (materials); irradiation; neurites;     Show all 6 Subjects
Abstract:
... Electron microscopy studies have demonstrated that the diameter of a focused electron beam is small enough to probe or manipulate subcellular domains of a single biological cell. Here, we report the development of a direct point electron beam irradiation system to investigate the biological functions of subcellular domains in a living cell. Subcellular structures of a single living cell cultured o ...
DOI:
10.1016/j.micron.2022.103214

17. The sperm ultrastructure of members of basal Tenebrionoidea (Coleoptera)

Author:
Glenda Dias; José Lino-Neto; David Mercati; Pietro Paolo Fanciulli; Pietro Lupetti; Romano Dallai
Source:
Arthropod structure & development 2022 v.66 pp. 101129
ISSN:
1467-8039
Subject:
plasma membrane,   etc   ; Mordellistena; Mylabris; acrosome; arthropods; flagellum; mitochondria; ultrastructure;     Show all 8 Subjects
Abstract:
... The sperm ultrastructure of some beetles of Tenebrionoidea was studied with particular attention to those of the Ripiphoridae, Mordellidae, and Meloidae. These three groups are often thought to form a clade, which is the sister group of the remaining Tenebrionoidea. The testes of the two former families have thinner but longer spermatic cysts containing fewer and longer sperm. Within each cyst all ...
DOI:
10.1016/j.asd.2021.101129

18. Calmodulin kinase 2 genetically interacts with Rch1p to negatively regulate calcium import into Saccharomyces cerevisiae after extracellular calcium pulse

Author:
Christian E. Coleman; Chelsea Landin; Abigail Neuer; Fadi M. Sayegh; Pamela A. Marshall
Source:
Archives of microbiology 2022 v.204 no.8 pp. 519
ISSN:
0302-8933
Subject:
plasma membrane,   etc   ; Saccharomyces cerevisiae; calcium; calmodulin; endoplasmic reticulum; imports; yeasts;     Show all 7 Subjects
Abstract:
... After a single extracellular 100 mM calcium pulse (final concentration), wild type S. cerevisiae exhibits a sharp peak in cytosolic calcium. The concentration drops rapidly in these cells as the calcium is sequestered away in the endoplasmic reticulum, Golgi, and vacuoles leaving resting cytosolic levels higher than their original state, followed by changes in gene expression. In cells lacking cal ...
DOI:
10.1007/s00203-022-03095-2

19. Phosphatidylinositol 4‐phosphate: a key determinant of plasma membrane identity and function in plants

Author:
Vedrana Marković; Yvon Jaillais
Source:
The new phytologist 2022 v.235 no.3 pp. 867-874
ISSN:
0028-646X
Subject:
plasma membrane,   etc   ; Golgi apparatus; animals; endoplasmic reticulum; exocytosis; phospholipids; yeasts;     Show all 7 Subjects
Abstract:
... Phosphatidylinositol 4‐phosphate (PI4P) is an anionic phospholipid which has been described as a master regulator of the Golgi apparatus in eukaryotic cells. However, recent evidence suggests that PI4P mainly accumulates at the plasma membrane in all plant cells analyzed so far. In addition, many functions that are typically attributed to phosphatidylinositol 4,5‐bisphosphate (PI(4,5)P₂) in animal ...
DOI:
10.1111/nph.18258

20. Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

Author:
Elke De Schutter; Jana Ramon; Benjamin Pfeuty; Caroline De Tender; Stephan Stremersch; Koen Raemdonck; Ken Op de Beeck; Wim Declercq; Franck B. Riquet; Kevin Braeckmans; Peter Vandenabeele
Source:
Cellular and molecular life sciences 2022 v.79 no.1 pp. 19
ISSN:
1420-682X
Subject:
plasma membrane,   etc   ; apoptosis; caspase-3; dextran; molecular weight; necrosis; phosphatidylserines;     Show all 7 Subjects
Abstract:
... Secondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME), which requires activation by caspase-3. Although the contribution of GSDME in this context has been attributed to its pore-forming capacity, little is known about the kin ...
DOI:
10.1007/s00018-021-04078-0