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1. Unique silica biomimetic mineralization of acidic elastin-like polypeptides without hydroxyl and charged residues

Author:
Qiu, Yue; Lin, Yuanqing; Zhang, Guangya
Source:
International journal of biological macromolecules 2020 v.153 pp. 224-231
ISSN:
0141-8130
Subject:
polypeptides,   etc   ; biomimetics; mineralization; mining; nanoparticles; silica;     Show all 6 Subjects
Abstract:
... Elastin-like polypeptides (ELPs), usually as a purification-tag, can be easily expressed and rapidly purified. We found ELPs[V9F-40], which did not contain hydroxyl or charged residues with the pI of 5.52, could biomimetically form silica when they were in ordered structure. The specific activity of ELPs[V9F-40] was 70.89 ± 9.53. Besides, the time needed for the completion of biomimetic silicifica ...
DOI:
10.1016/j.ijbiomac.2020.03.007

2. Elastin-Based Thermoresponsive Shape-Memory Hydrogels

Author:
Zhang, Yuancheng; Desai, Malav S.; Wang, Tao; Lee, Seung-Wuk
Source:
Biomacromolecules 2020 v.21 no.3 pp. 1149-1156
ISSN:
1526-4602
Subject:
polypeptides,   etc   ; acrylamides; crosslinking; hydrogels; polyacrylamide; polymerization; temperature;     Show all 7 Subjects
Abstract:
... A shape-memory hydrogel is a programmable hydrogel material that can store specific shapes and execute functions in response to stimuli. In this report, we developed shape-memory hydrogels by creating double-network polymeric structures using a physically cross-linking elastin-like polypeptide (ELP) and a chemically cross-linking polyacrylamide (PAM). We synthesized the hydrogel matrix by polymeri ...
DOI:
10.1021/acs.biomac.9b01541

3. Proteomics and Immunology Provide Insight into the Degradation Mechanism of Historic and Artificially Aged Silk

Author:
Chen, Ruru; Hu, Mingzhou; Zheng, Hailing; Yang, Hui; Zhou, Lian; Zhou, Yang; Peng, Zhiqin; Hu, Zhiwen; Wang, Bing
Source:
Analytical chemistry 2020 v.92 no.3 pp. 2435-2442
ISSN:
1520-6882
Subject:
polypeptides,   etc   ; immunology; models; proteomics; silk; silk fabric;     Show all 6 Subjects
Abstract:
... The process and mechanism of silk degradation is still a bewildering mystery in the investigation and conservation of cultural relics, which rely on the development of accurate and tailored analysis technologies. Here, two advanced approaches, proteomics and immunology, were developed for determining the deterioration behavior of historic silk fabrics and artificially aged samples from the molecul ...
DOI:
10.1021/acs.analchem.9b03616

4. Modification of Poly(5,6-epoxy-l-norleucine) Gives Functional Polypeptides with Alternative Side-Chain Linkages

Author:
Perlin, Pesach; Scott, Wendell A.; Deming, Timothy J.
Source:
Biomacromolecules 2019 v.21 no.1 pp. 126-132
ISSN:
1526-4602
Subject:
polypeptides,   etc   ; solubility; thiols;     Show all 3 Subjects
Abstract:
... The preparation and characterization of a new epoxide containing polypeptide, poly(5,6-epoxy-l-norleucine), via postpolymerization modification of poly(l-homoallylglycine) is described. Addition of thiols to the epoxide groups in poly(5,6-epoxy-l-norleucine) was studied as a means to prepare side-chain functional polypeptides. The solution properties of the derivatized polypeptides were studied in ...
DOI:
10.1021/acs.biomac.9b01065

5. Reactive Conjugated Polymers for the Modulation of Islet Amyloid Polypeptide Assembly

Author:
Sun, Han; Lv, Fengting; Liu, Libing; Wang, Shu
Source:
ACS applied materials & interfaces 2019 v.11 no.26 pp. 22973-22978
ISSN:
1944-8252
Subject:
polypeptides,   etc   ; amyloid; cytotoxicity; polymers;     Show all 4 Subjects
Abstract:
... Misfolding and abnormal assembly of proteins cause many intractable diseases. The modulation of the assembly process of these proteins could contribute to understanding and controlling amyloid protein aggregation. Previous works focused mainly on the inhibition of the assembly process. To broaden the interaction modality of modulators with proteins for developing new modulators, in this work, we d ...
DOI:
10.1021/acsami.9b05247

6. Proximity-Induced Cooperative Polymerization in “Hinged” Helical Polypeptides

Author:
Chen, Chongyi; Fu, Hailin; Baumgartner, Ryan; Song, Ziyuan; Lin, Yao; Cheng, Jianjun
Source:
Journal of the American Chemical Society 2019 v.141 no.22 pp. 8680-8683
ISSN:
1520-5126
Subject:
polypeptides,   etc   ; 1,6-hexanediamine; polymerization;     Show all 3 Subjects
Abstract:
... Cooperative interactions and transitions are among the most important strategies utilized by biological systems to regulate a variety of physical and chemical processes. We report herein an auto-accelerated, rapid cooperative polymerization of N-carboxyanhydrides (NCAs) with initiators structurally as simple as linear aliphatic diamines for the synthesis of polypeptides. The polymerization initiat ...
DOI:
10.1021/jacs.9b02298

7. Natural polypeptides-based electrically conductive biomaterials for tissue engineering

Author:
Vandghanooni, Somayeh; Eskandani, Morteza
Source:
International journal of biological macromolecules 2020 v.147 pp. 706-733
ISSN:
0141-8130
Subject:
polypeptides,   etc   ; biocompatible materials; biopolymers; electric field; extracellular matrix; tissue engineering;     Show all 6 Subjects
Abstract:
... Fabrication of an appropriate scaffold is the key fundamental step required for a successful tissue engineering (TE). The artificial scaffold as extracellular matrix in TE has noticeable role in the fate of cells in terms of their attachment, proliferation, differentiation, orientation and movement. In addition, chemical and electrical stimulations affect various behaviors of cells such as polarit ...
DOI:
10.1016/j.ijbiomac.2019.12.249

8. Fibril Self-Assembly of Amyloid–Spider Silk Block Polypeptides

Author:
Dai, Bin; Sargent, Cameron J.; Gui, Xinrui; Liu, Cong; Zhang, Fuzhong
Source:
Biomacromolecules 2019 v.20 no.5 pp. 2015-2023
ISSN:
1526-4602
Subject:
polypeptides,   etc   ; amyloid; silk; thermal stability;     Show all 4 Subjects
Abstract:
... Because of their association with debilitating diseases and their potential applications in developing novel bionanomaterials, highly ordered amyloid fibrils have recently received considerable attention. While many studies have thus far focused on amyloid fibrils made with short peptides containing just one steric zipper-forming segment of native amyloid proteins, the self-assembly of proteins co ...
DOI:
10.1021/acs.biomac.9b00218

9. Versatile N-Methylaminooxy-Functionalized Polypeptides for Preparation of Neoglycoconjugates

Author:
Wollenberg, Alexander L.; Perlin, Pesach; Deming, Timothy J.
Source:
Biomacromolecules 2019 v.20 no.4 pp. 1756-1764
ISSN:
1526-4602
Subject:
polypeptides,   etc   ; glycoproteins; hydrophobicity; moieties; pH;     Show all 5 Subjects
Abstract:
... The preparation and characterization of a new set of well-defined polypeptides containing N-methylaminooxy side-chain functionality is described. These functional groups enabled the direct coupling of polypeptides with a variety of unmodified reducing saccharides in water to give neoglycopolypeptides in high yields. The use of different polypeptide scaffolds resulted in neoglycoconjugates with tun ...
DOI:
10.1021/acs.biomac.9b00138

10. Orientational and Folding Thermodynamics via Electric Dipole Moment Restraining

Author:
Garate, Jose Antonio; Bernardin, Alejandro; Escalona, Yerko; Yanez, Carlos; English, Niall J.; Perez-Acle, Tomas
Source:
TheJournal of physical chemistry 2019 v.123 no.12 pp. 2599-2608
ISSN:
1520-5207
Subject:
polypeptides,   etc   ; electric potential difference; thermodynamics;     Show all 3 Subjects
Abstract:
... The projection of molecular processes onto a small set of relevant descriptors, the so-called reaction coordinates or collective variables (CVs), is a technique nowadays routinely employed by the biomolecular simulation community. In this work, we implemented two CVs to manipulate the orientation (i.e., angle) (μ⃗ₐ) and magnitude (|μ⃗|) of the electric dipole moment. In doing so, we studied the th ...
DOI:
10.1021/acs.jpcb.8b09374

11. Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists

Author:
Gasbjerg, Lærke S.; Bergmann, Natasha C.; Stensen, Signe; Christensen, Mikkel B.; Rosenkilde, Mette M.; Holst, Jens J.; Nauck, Michael; Knop, Filip K.
Source:
Peptides 2020 v.125 pp. 170183
ISSN:
0196-9781
Subject:
gastric inhibitory polypeptide; gastric inhibitory polypeptide receptors,   etc   ; antagonists; glucagon-like peptide 1; humans; insulin secretion; intestines; noninsulin-dependent diabetes mellitus; patients; secretin;     Show all 10 Subjects
Abstract:
... Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) potentiate glucose-induced insulin secretion and are therefore thought to be responsible for the incretin effect. The magnitude of the incretin effect, defined as the fraction of postprandial insulin secretion stimulated by intestinal factors, has been reported to be up to ∼60% in healthy individuals. In several ...
DOI:
10.1016/j.peptides.2019.170183

12. Molecular interactions of full-length and truncated GIP peptides with the GIP receptor – A comprehensive review

Author:
Smidt Gasbjerg, Lærke; Gabe, Maria Buur Nordskov; van der Velden, Wijnand J.C.; Smit, Florent Xavier; Gasbjerg, Lærke Smidt; Rosenkilde, Mette Marie
Source:
Peptides 2020 v.125 pp. 170224
ISSN:
0196-9781
Subject:
gastric inhibitory polypeptide; gastric inhibitory polypeptide receptors,   etc   ; agonists; amino acids; antagonism; antagonists; cytokines; glucagon; glucagon-like peptide 1; glucagon-like peptide 2; ligands; pharmacology; secretin; therapeutics; tissue distribution;     Show all 15 Subjects
Abstract:
... Enzymatic cleavage of endogenous peptides is a commonly used principle to initiate, modulate and terminate action for instance among cytokines and peptide hormones. The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and the related hormone glucagon-like peptide-2 (GLP-2) are all rapidly N-terminally truncated with severe loss of intrinsic ...
DOI:
10.1016/j.peptides.2019.170224

13. The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system

Author:
Adriaenssens, A.E.; Gribble, F.M.; Reimann, F.
Source:
Peptides 2020 v.125 pp. 170194
ISSN:
0196-9781
Subject:
gastric inhibitory polypeptide; gastric inhibitory polypeptide receptors,   etc   ; appetite; brain; diabetes; epithelium; glucagon-like peptide 1; islets of Langerhans; neuroprotective effect; obesity; secretin; small intestine; therapeutics;     Show all 13 Subjects
Abstract:
... Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone released from the epithelium of the upper small intestine. While GIP shares common actions on the pancreatic beta cell with glucagon-like peptide-1 (GLP-1), unlike GLP-1, GIP presents a complex target for the development of diabetes and obesity therapies due to its extra-pancreatic effects on fat mass. Recent pharmacological ...
DOI:
10.1016/j.peptides.2019.170194

14. The role of GIP in α-cells and glucagon secretion

Author:
El, Kimberley; Campbell, Jonathan E.
Source:
Peptides 2020 v.125 pp. 170213
ISSN:
0196-9781
Subject:
gastric inhibitory polypeptide; gastric inhibitory polypeptide receptors,   etc   ; blood glucose; glucagon; glucose; homeostasis; humans; hyperglycemia; insulin; insulin secretion; islets of Langerhans; metabolism; noninsulin-dependent diabetes mellitus; pathogenesis; postprandial state;     Show all 15 Subjects
Abstract:
... Glucose-dependent insulinotropic polypeptide (GIP) is an intestinally derived peptide that is secreted in response to feeding. The GIP receptor (GIPR) is expressed in many cell types involved in the regulation of metabolism, including α- and β-cells. Glucagon and insulin exert tremendous control over glucose metabolism. Thus, GIP action in islets strongly dictates metabolic control in the postpran ...
DOI:
10.1016/j.peptides.2019.170213

15. Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface

Author:
Tira, Roberto; De Cecco, Elena; Rigamonti, Valentina; Santambrogio, Carlo; Barracchia, Carlo Giorgio; Munari, Francesca; Romeo, Alessandro; Legname, Giuseppe; Prosperi, Davide; Grandori, Rita; Assfalg, Michael
Source:
International journal of biological macromolecules 2020 v.154 pp. 206-216
ISSN:
0141-8130
Subject:
polypeptides,   etc   ; blood serum; colloids; nanoparticles; neurodegenerative diseases; nuclear magnetic resonance spectroscopy; oxidation; proteins; silica; solutes;     Show all 10 Subjects
Abstract:
... The notion that nanoscale surfaces influence protein conformational transitions stimulates the investigation of fibrillogenic polypeptides adsorbing to nanomaterials. Alpha-synuclein (αS) is a prototypical amyloidogenic protein whose aggregation is associated with severe neurodegenerative disorders. We explored the interaction of αS with silica nanoparticles (SNPs) in diverse solution conditions, ...
DOI:
10.1016/j.ijbiomac.2020.03.118

16. Facile dual-functionalization of polyamide reverse osmosis membrane by a natural polypeptide to improve the antifouling and chlorine-resistant properties

Author:
Zhang, Xiaotai; Huang, Hai; Li, Qiang; Yu, Hui; Tian, Xinxia; Zhao, Man; Zhang, Huifeng
Source:
Journal of membrane science 2020 v.604 pp. 118044
ISSN:
0376-7388
Subject:
polypeptides,   etc   ; artificial membranes; chemical bonding; chlorination; durability; films (materials); hydrophilicity; polyamides; reverse osmosis; water treatment;     Show all 10 Subjects
Abstract:
... Long-term durability is of significant importance for the polyamide thin film composite (PA-TFC) reverse osmosis (RO) membranes under the complicated operation conditions of the water treatment. Herein, dual-functional RO membranes with improved antifouling and chlorine-resistant properties were facilely fabricated. A natural polypeptide, ε-poly-l-lysine (PL), was employed as the surface modifier ...
DOI:
10.1016/j.memsci.2020.118044

17. Comparison of protein extraction methods from excess activated sludge

Author:
Gao, Jianlei; Weng, Wei; Yan, Yixin; Wang, Yingchun; Wang, Qikun
Source:
Chemosphere 2020 v.249 pp. 126107
ISSN:
0045-6535
Subject:
polypeptides,   etc   ; activated sludge; amino acids; dewatering; energy; enzymatic treatment; feeds; foaming; hydrolysis; protein hydrolysates; ultrasonics;     Show all 11 Subjects
Abstract:
... In this study, we used chemical methods (acid-thermal (AT) and alkaline-thermal (AKT)), enzymatic methods (single enzyme (SE) and composite enzyme (CE)) and assisted enzymatic methods (ultrasonic assisted enzyme (USE) and thermal assisted enzyme (TE)) to extract proteins from excess activated sludge. The advantages and applicability of each method were compared and analyzed in terms of their prote ...
DOI:
10.1016/j.chemosphere.2020.126107

18. Application of short hydrophobic elastin-like polypeptides for expression and purification of active proteins

Author:
Yang, Chun-Guang; Lang, Ming-Fei; Fu, Xin; Lin, Heng; Zhang, Li-Chao; Ge, Gao-Shun; Sun, Jing; Hu, Xue-Jun
Source:
3 Biotech 2020 v.10 no.4 pp. 156
ISSN:
2190-572X
Subject:
polypeptides,   etc   ; Escherichia coli; fluorescence; fluorescence emission spectroscopy; hydrophobicity; protein content; protein synthesis; proteins; salts; temperature;     Show all 10 Subjects
Abstract:
... To investigate the application of short elastin-like polypeptides (ELPs) in the purification of bioactive proteins, short hydrophobic ELP[I]ₙ (n = 30, 40, 50) tags were constructed. Both the ELP[I]ₙ tags and the ELP[I]ₙ–Trx fusion proteins could be stably expressed in Escherichia coli and purified by inverse transition cycling, respectively. Total protein concentrations determined by BCA protein a ...
DOI:
10.1007/s13205-020-2139-0
PubMed:
32181118
PubMed Central:
PMC7056756

19. Self-assembling RATEA16 peptide nanofiber designed for rapid hemostasis

Author:
Wei, Shuda; Chen, Fangping; Geng, Zhen; Cui, Ruihua; Zhao, Yujiao; Liu, Changsheng
Source:
Journal of materials chemistry B 2020 v.8 no.9 pp. 1897-1905
ISSN:
2050-7518
Subject:
polypeptides,   etc   ; accidents; animals; aspartic acid; biocompatibility; blood coagulation; gelation; hemorrhage; hemostasis; liver; models; mortality; nanofibers; pH;     Show all 14 Subjects
Abstract:
... Uncontrolled bleeding remains a contributor of mortality in various accidents, and ideal hemostatic materials with rapid and efficient hemostasis, ease of use, biocompatibility and non-toxic characteristics are urgently needed. In this study, we synthesized a novel polypeptide material, RATEA16 (CH₃CO-RATARAEARATARAEA-CONH₂), by the solid phase method, and investigated the secondary structure, sel ...
DOI:
10.1039/c9tb02590a

20. Kinetic Hydrate Inhibition of Glycyl-valine-Based Alternating Peptoids with Tailor-Made N-Substituents

Author:
Zhang, Qian; Koyama, Yasuhito; Ihsan, Abu Bin; Kelland, Malcolm A.
Source:
Energy & fuels 2020 v.34 no.4 pp. 4849-4854
ISSN:
1520-5029
Subject:
polypeptides,   etc   ; N-substituted glycines; caprolactam; cooling; dipeptides; moieties; molecular weight; natural gas; temperature; valine;     Show all 10 Subjects
Abstract:
... A series of alternating peptides with glycine-N-substituted valine dipeptide repeating units were synthesized. The N-substitution included methyl, ethyl, n-propyl, and hydroxyl groups. The performance of the polypeptides as kinetic hydrate inhibitors (KHIs) was evaluated in high pressure rocking cells with a synthetic natural gas mixture using the slow constant cooling method. All the polypeptides ...
DOI:
10.1021/acs.energyfuels.9b04321