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1. Dynamic domain expansion in smoke spread simulations with ARTSS: Speedup and overhead

Author:
Würzburger, My Linh; Arnold, Lukas
Source:
Fire safety journal 2021 v.120 pp. 103168
ISSN:
0379-7112
Subject:
prognosis,   etc   ; computer software; smoke;     Show all 3 Subjects
Abstract:
... This paper describes the impact and consequences of a dynamic domain expansion in a smoke simulation performed in the software ARTSS. This software is developed with the aim to conduct real-time or even prognosis computations by using GPUs as the main computational architecture. Further runtime acceleration is proposed by means of a dynamic expansion of the computational domain. This approach is b ...
DOI:
10.1016/j.firesaf.2020.103168

2. Functionalized nanoprobes for in situ detection of telomerase

Author:
Yu, Zhengze; Jiang, Fan; Hu, Chenchen; Tang, Bo
Source:
Chemical communications 2021 v.57 no.31 pp. 3736-3748
ISSN:
1364-548X
Subject:
prognosis,   etc   ; biomarkers; cell proliferation; ribonucleoproteins; telomerase; telomeres;     Show all 6 Subjects
Abstract:
... Telomerase, a special ribonucleoprotein reverse transcriptase, can maintain the length and stability of telomeres and plays an important role in cell proliferation and differentiation. Due to the distinguishable expression level in normal cells and cancer cells, telomerase has become an important biomarker for cancer diagnosis and prognosis evaluation. Despite major breakthroughs in the field of t ...
DOI:
10.1039/d0cc08412c

3. The Appropriateness of Invasive Ventilation in COVID-19 Positive Cancer Patients: Proposal of a New Prognostic Score

Author:
Ghidini, Michele; Indini, Alice; Rijavec, Erika; Bareggi, Claudia; Cattaneo, Monica; Tomasello, Gianluca; Galassi, Barbara; Gambini, Donatella; Grossi, Francesco
Source:
Viruses 2021 v.13 no.3
ISSN:
1999-4915
Subject:
prognosis,   etc   ; COVID-19 infection; longevity; patients;     Show all 4 Subjects
Abstract:
... Over the last months, as oncology specialists, we have frequently been contacted for estimating prognosis for cancer patients affected by COVID-19 infection. Until now, there have been no clear markers to guide decision making regarding the appropriateness of invasive ventilation in cancer patients affected by COVID-19 infection. We developed a practical tool encompassing a prognostic score, “The ...
DOI:
10.3390/v13030508

4. Ultrasensitive detection of programmed death-ligand 1 (PD-L1) in whole blood using dispersible electrodes

Author:
Moazzam, Parisa; Myekhlai, Munkhshur; Alinezhad, Ali; Alshawawreh, Fida’a A.; Bakthavathsalam, Padmavathy; Gonçales, Vinicius R; Tilley, Richard D.; Gooding, J. Justin
Source:
Chemical communications 2021 v.57 no.20 pp. 2559-2562
ISSN:
1364-548X
Subject:
prognosis,   etc   ; biomarkers; blood; detection limit; electrochemistry; magnetism;     Show all 6 Subjects
Abstract:
... The direct quantification of programmed death-ligand 1 (PD-L1) as a biomarker for cancer diagnosis, prognosis and treatment efficacy is an unmet clinical need. Herein, we demonstrate the first report of rapid, ultrasensitive and selective electrochemical detection of PD-L1 directly in undiluted whole blood using modified gold-coated magnetic nanoparticles as “dispersible electrodes” with an ultral ...
DOI:
10.1039/d0cc08068c

5. Equine colic associated with small intestinal epiploic foramen entrapment

Author:
van Bergen, Thomas; Wiemer, Peter; Martens, Ann
Source:
The veterinary journal 2021 v.269 pp. 105608
ISSN:
1090-0233
Subject:
prognosis,   etc   ; colic; hemorrhage; horses; ileum; laparotomy;     Show all 6 Subjects
Abstract:
... Intestinal epiploic foramen entrapment (EFE) is an important differential diagnosis in horses with colic, but disappointing short- and long-term outcomes are reported in the scientific literature. Many horses are euthanased during surgery due to a predicted poor prognosis or due to uncontrollable intraoperative haemorrhage. The ileum is involved in the majority of cases. Several risk factors for t ...
DOI:
10.1016/j.tvjl.2021.105608

6. Laparoscopic versus Open Colectomy for Elderly Patients with Colon Cancer: A Propensity Score Analysis with the Controlling Nutritional Status (CONUT) Score

Author:
Horie, Tomoko; Shida, Dai; Ahiko, Yuka; Takamizawa, Yasuyuki; Inoue, Manabu; Tanabe, Taro; Nakamura, Yuya; Imaizumi, Jun; Tsukamoto, Shunsuke; Kanemitsu, Yukihide
Source:
Nutrition and cancer 2021 v.73 no.2 pp. 246-251
ISSN:
1532-7914
Subject:
prognosis,   etc   ; colorectal neoplasms; elderly; laparoscopy; nutritional status;     Show all 5 Subjects
Abstract:
... The feasibility of laparoscopic surgery for elderly patients remains unclear, as these patients usually present with comorbidities. Recently, the controlling nutritional status (CONUT) score has drawn attention as an evaluation score of patients’ general status as well as a predictor of survival. We retrospectively analyzed overall survival in 424 patients aged ≥75 years with colon cancer, who und ...
DOI:
10.1080/01635581.2020.1743868

7. Role of β2-adrenergic receptors in chronic obstructive pulmonary disease

Author:
Yang, Ailin; Yu, Ganggang; Wu, Yanjun; Wang, Haoyan
Source:
Life sciences 2021 v.265 pp. 118864
ISSN:
0024-3205
Subject:
prognosis,   etc   ; autoantibodies; pathogenesis; respiratory tract diseases;     Show all 4 Subjects
Abstract:
... Beta-2 adrenergic receptors (β2-ARs) have important roles in the pathogenesis and treatment of chronic obstructive pulmonary disease (COPD). In recent years, progress has been made in the study of β2-ARs. Here, we introduce the basic concepts of β2-ARs, related pathways, as well as application of blockers/agonists of β2-ARs, and β2-AR autoantibodies in COPD. Drugs targeting the β2-AR are being dev ...
DOI:
10.1016/j.lfs.2020.118864

8. Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactions

Author:
Gomes, Luciano Teixeira; Morato-Conceição, Yvelise Terezinha; Gambati, Ana Vitória Mota; Maciel-Pereira, Carolina Mira; Fontes, Cor Jesus Fernandes
Source:
Heliyon 2020 v.6 no.2 pp. e03369
ISSN:
2405-8440
Subject:
prognosis,   etc   ; biomarkers; inflammation; leprosy;     Show all 4 Subjects
Abstract:
... Leprosy reactions, classified as type 1 and type 2 reactions, are acute clinical conditions of exacerbation of localized or systemic inflammatory response inpatients with leprosy. No laboratory biomarker is available to predict the emergence of these reactions. Neutrophil-to-lymphocyte ratio (NLR) is an accurate biomarker for diagnosis and prognosis of various inflammatory and neoplastic diseases. ...
DOI:
10.1016/j.heliyon.2020.e03369

9. Identification of MCM family as potential therapeutic and prognostic targets for hepatocellular carcinoma based on bioinformatics and experiments

Author:
Lei, Yu; Wang, Shuhui; Liu, Jingmei; Yan, Wei; Han, Ping; Tian, Dean
Source:
Life sciences 2021 v.272 pp. 119227
ISSN:
0024-3205
Subject:
prognosis,   etc   ; DNA replication; bioinformatics; drugs; hepatoma; immunohistochemistry; protein synthesis; therapeutics;     Show all 8 Subjects
Abstract:
... The minichromosome maintenance (MCM) complex is highly conserved, which has drawn increasing attention on physiology and pathology process. However, the role of MCM in hepatocellular carcinoma (HCC) remains largely unclear. We aimed to conduct systematic analysis of expression patterns, prognostic values and potential functions of nine MCM genes in HCC, thus identifying their role in HCC.In our st ...
DOI:
10.1016/j.lfs.2021.119227

10. Dual down‐regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells

Author:
Chuang, Tzu‐Chao; Wu, Kuohui; Lin, Ying‐Yu; Kuo, Han‐Peng; Kao, Ming‐Ching; Wang, Vinchi; Hsu, Shih‐Chung; Lee, Shou‐Lun
Source:
Environmental toxicology 2021 v.36 no.5 pp. 737-747
ISSN:
1520-4081
Subject:
prognosis,   etc   ; berberine; cyclins; ecotoxicology; humans; ovarian neoplasms; proteasome endopeptidase complex;     Show all 7 Subjects
Abstract:
... The overexpression of EGFR and/or ErbB2 occurs frequently in ovarian cancers and is associated with poor prognosis. The purpose of this study was to examine the anticancer effects and molecular mechanisms of berberine on human ovarian cancer cells with different levels of EGFR and/or ErbB2. We found that berberine reduced the motility and invasiveness of ovarian cancer cells. Berberine depleted bo ...
DOI:
10.1002/tox.23076

11. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement

Author:
Li, Haojiang; Chen, Mingyang; Liang, Shaobo; Wei, Xiaoyu; Wang, Ruixin; Cui, Chunyan; Ruan, Guangying; Ou, Qiaowen; Liu, Lizhi
Source:
Clinical nutrition 2021 v.40 no.4 pp. 2293-2300
ISSN:
0261-5614
Subject:
prognosis,   etc   ; carcinoma; clinical nutrition; dosage; endpoints; patients; pyridoxine; risk; testing;     Show all 9 Subjects
Abstract:
... Several studies explored the association of vitamin B6 intake with the risk of cancers. However, it is unclear whether different doses of vitamin B6 have distinct effects on the prognosis of nasopharyngeal carcinoma (NPC) patients. This study investigated the relationship between different doses of B6 intake and the prognosis of NPC patients.This retrospective cohort analysis included 792 newly di ...
DOI:
10.1016/j.clnu.2020.10.019

12. Myosin18B predicts favorable prognosis of cutaneous squamous-cell carcinoma

Author:
Cao, Can; Zhang, Chao; Sun, Ying; Mu, Zhen; Shen, Qin
Source:
Genes & genomics 2021 v.43 no.4 pp. 371-378
ISSN:
1976-9571
Subject:
prognosis,   etc   ; biomarkers; genomics; immunohistochemistry; models; monitoring; myosin; neoplasm progression;     Show all 8 Subjects
Abstract:
... BACKGROUND: Myosin18 family, including Myosin18A (MYO18A) and Myosin18B (MYO18B), are newly-identified Myosins in Myosin superfamily. The expression and function of Myosin18 family in cancer progression is still controversial, and in cutaneous squamous-cell carcinoma (cSCC) is totally unknown. OBJECTIVE: To investigate the expression and prognostic significance of Myosin18 family in cSCC. METHODS: ...
DOI:
10.1007/s13258-021-01037-8

13. The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis

Author:
Kulkarni, Aneesha; Bowers, Laura W.
Source:
Cellular and molecular life sciences 2021 v.78 no.7 pp. 3423-3442
ISSN:
1420-682X
Subject:
prognosis,   etc   ; adipose tissue; immunosuppression; inflammation; metastasis; neoplasms; obesity; risk;     Show all 8 Subjects
Abstract:
... Obesity has been linked to an increased risk of and a worse prognosis for several types of cancer. A number of interrelated mediators contribute to obesity’s pro-tumor effects, including chronic adipose inflammation and other perturbations of immune cell development and function. Here, we review studies examining the impact of obesity-induced immune dysfunction on cancer risk and progression. Whil ...
DOI:
10.1007/s00018-020-03752-z

14. The differentiation of colorectal cancer is closely relevant to m6A modification

Author:
Wang, Shuai; Fan, Xiaoyan; Zhu, Jun; Xu, Dong; Li, Ruikai; Chen, Rujie; Hu, Junbi; Shen, Yao; Hao, Jun; Wang, Ke; Jiang, Xunliang; Wang, Yaofeng; Jiang, Yu; Li, Jipeng; Zhang, Jian
Source:
Biochemical and biophysical research communications 2021 v.546 pp. 65-73
ISSN:
0006-291X
Subject:
prognosis,   etc   ; cadherins; cell differentiation; colorectal neoplasms; models; research; sodium butyrate;     Show all 7 Subjects
Abstract:
... The occurrence and development of tumors cannot be separated from the influence of differentiation at different stages and levels. Our study found that E-cadherin was significantly increased in cell model induced by sodium butyrate and cell density, while METTL3, METTL16 and WTAP were decreased during the differentiation of cells. In the clinicopathological tissues, E-cadherin was low expressed in ...
DOI:
10.1016/j.bbrc.2021.02.001

15. TPX2 mediates prostate cancer epithelial-mesenchymal transition through CDK1 regulated phosphorylation of ERK/GSK3β/SNAIL pathway

Author:
Zhang, Boya; Zhang, Mingpeng; Li, Qi; Yang, Yanjie; Shang, Zhiqun; Luo, Jun
Source:
Biochemical and biophysical research communications 2021 v.546 pp. 1-6
ISSN:
0006-291X
Subject:
prognosis,   etc   ; metastasis; phenotype; phosphorylation; precision medicine; prostatic neoplasms; research;     Show all 7 Subjects
Abstract:
... Prostate cancer with high Gleason grade is prone to metastasis, which is one of the factors that seriously threaten the survival of patients, and it is also a treatment difficulty. In this study, we first revealed the potential connection between TPX2 and prostate cancer metastasis. We found that TPX2 is highly expressed in high-grade prostate cancer and is significantly related to poor prognosis. ...
DOI:
10.1016/j.bbrc.2021.01.106

16. Nasopharyngeal carcinoma related miRNA detection through a DSN enzyme assisted tetrahedral probe for more accurate prognosis

Author:
Zhang, Li; Lou, Zhiping
Source:
RSC advances 2021 v.11 no.19 pp. 11398-11402
ISSN:
2046-2069
Subject:
prognosis,   etc   ; carcinoma; detection limit; enzymes; fluorescence; microRNA; transfection;     Show all 7 Subjects
Abstract:
... MicroRNAs (miRNAs) play a pivotal role in cellular functions and in the development and progression of cancer. Precise quantification of miRNAs from different clinical samples is a challenging but necessary endeavor that is largely neglected by many emerging fluorescence technologies. Herein, we propose here a novel miRNA detection method through a designed tetrahedral probe and DSN enzyme for att ...
DOI:
10.1039/d1ra00539a

17. How does fascin promote cancer metastasis?

Author:
Lin, Shengchen; Taylor, Matthew D.; Singh, Pankaj K.; Yang, Shengyu
Source:
TheFEBS journal 2021 v.288 no.5 pp. 1434-1446
ISSN:
1742-464X
Subject:
prognosis,   etc   ; actin; cell movement; crosslinking; metastasis; neoplasm cells; therapeutics;     Show all 7 Subjects
Abstract:
... Fascin is an F‐actin‐bundling protein that cross‐links individual actin filaments into straight and stiff bundles. Fascin overexpression in cancer is strongly associated with poor prognosis and metastatic progression across different cancer types. It is well established that fascin plays a causative role in promoting metastatic progression. We will review the recent progress in our understanding o ...
DOI:
10.1111/febs.15484

18. MicroRNA-101-3p, MicroRNA-195-5p, and MicroRNA-223-3p in Peripheral Blood Mononuclear Cells May Serve as Novel Biomarkers for Syphilis Diagnosis

Author:
Yang, Jieyi; Huang, Tao; Zhao, Peizhen; Lin, Xiaomian; Feng, Zanqin; Senhong chen,; Xue, Yaohua; Chen, Wentao; Zhao, Yunhu; Yang, Bin; Zheng, Heping
Source:
Microbial pathogenesis 2021 v.152 pp. 104769
ISSN:
0882-4010
Subject:
prognosis,   etc   ; biomarkers; early diagnosis; microRNA; pathogenesis; sexually transmitted diseases;     Show all 6 Subjects
Abstract:
... Syphilis is a sexually transmitted disease of global prevalence. Current diagnostic methods lack sensitivity and specificity, which limits the early diagnosis and prognosis of the disease. MiRNAs hold great promise as potential biomarkers for infectious diseases diagnosis. We previously profiled the expression of miRNAs in PBMCs from patients with different stages of syphilis. We aimed to further ...
DOI:
10.1016/j.micpath.2021.104769

19. Prognostic value of pretreatment plasma D‐dimer level in dogs with intermediate to high‐grade non‐Hodgkin lymphoma

Author:
Boyé, Pierre; Serres, François; Floch, Franck; Fournel‐Fleury, Corinne; Tierny, Dominique
Source:
Veterinary and comparative oncology 2021 v.19 no.1 pp. 44-52
ISSN:
1476-5810
Subject:
prognosis,   etc   ; etoposide; humans; immunophenotype; multivariate analysis; non-Hodgkin lymphoma; phosphates;     Show all 7 Subjects
Abstract:
... Pretreatment D‐dimer levels have been reported to predict survival in several types of malignancies in human patients. The objective of this study was to evaluate the prognostic value of pretreatment D‐dimer level in dogs with intermediate to high‐grade non‐Hodgkin lymphoma (NHL). In a prospective, randomized, double‐blind study of F14512 vs etoposide phosphate, we assessed the prognostic value of ...
DOI:
10.1111/vco.12629

20. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

Author:
Cheng, Sijin; Li, Ziyi; Gao, Ranran; Xing, Baocai; Gao, Yunong; Yang, Yu; Qin, Shishang; Zhang, Lei; Ouyang, Hanqiang; Du, Peng; Jiang, Liang; Zhang, Bin; Yang, Yue; Wang, Xiliang; Ren, Xianwen; Bei, Jin-Xin; Hu, Xueda; Bu, Zhaode; Ji, Jiafu; Zhang, Zemin
Source:
Cell 2021 v.184 no.3 pp. 792-809.e23
ISSN:
0092-8674
Subject:
prognosis,   etc   ; genes; humans; macrophages; neoplasm progression; neoplasms; phenotype; transcription (genetics);     Show all 8 Subjects
Abstract:
... Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the similarity and distinction of their fundamental properties across different tumors remain elusive. Here, by performing a pan-cancer analysis of single myeloid cells from 210 patients across 15 human cancer types, we identified distinct features of TIMs across cancer types. Mast cells in nasopharyngeal cancer w ...
DOI:
10.1016/j.cell.2021.01.010