PubAg

Main content area

You searched for: Subject "promastigotes" Remove constraint Subject: "promastigotes"
Start Over

Search

634  Search Results

« Previous | 1 - 20 of 634 |
Number of results to display per page

Search Results

1. Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection

Author:
Wei, Furong; Gong, Wenci; Wang, Junyun; Yang, Yuetao; Liu, Jianxiu; Wang, Yanjuan; Cao, Jianping
Source:
Parasites & vectors 2019 v.12 no.1 pp. 275
ISSN:
1756-3305
Subject:
promastigotes,   etc   ; Leishmania infantum; antagonists; extrusion; histones; inflammation; leishmaniasis; mechanism of action; neutrophils; therapeutics;     Show all 10 Subjects
Abstract:
... BACKGROUND: Neutrophils play an immunomodulatory role through the release of neutrophil extracellular traps (NETs). NETs are released in response to Leishmania infection, but the mechanism of NET extrusion has not been elucidated. The lipoxin A4 receptor on neutrophils is crucial for the inflammatory response and immune regulation of many diseases, including Leishmania infection. Therefore, in the ...
DOI:
10.1186/s13071-019-3530-8

2. The impact of arginase activity on virulence factors of Leishmania amazonensis

Author:
Aoki, Juliana Ide; Laranjeira-Silva, Maria Fernanda; Muxel, Sandra Marcia; Floeter-Winter, Lucile Maria
Source:
Current opinion in microbiology 2019 v.52 pp. 110-115
ISSN:
1369-5274
Subject:
promastigotes,   etc   ; Leishmania amazonensis; amastigotes; arginase; enzyme activity; immune response; parasites; polyamines; transcriptomics; vaccines; virulence;     Show all 11 Subjects
Abstract:
... The outcome of Leishmania infection depends on the parasite species and the host immune response. Virulence factors have been extensively studied over the years in an effort to find efficient vaccines and/or treatments for Leishmania infection. Arginase activity in Leishmania has been described as an essential player for the polyamines pathway, impacting parasite replication and infectivity. Consi ...
DOI:
10.1016/j.mib.2019.06.003

3. Potent leishmanicidal and antibacterial metabolites from Olea ferruginea

Author:
Zafar, Salman; -Ur-Rehman, Faiz; Shah, Zafar Ali; Rauf, Abdur; Khan, Aziz; Humayun Khan, Muhammad; Ur Rahman, Khaliq; Khan, Serab; Ullah, Abid; Shaheen, Farzana
Source:
Journal of Asian natural products research 2019 v.21 no.7 pp. 679-687
ISSN:
1477-2213
Subject:
promastigotes,   etc   ; Leishmania tropica; Olea; antibacterial properties; chromatography; ethyl acetate; metabolites; pathogens; spectroscopy;     Show all 9 Subjects
Abstract:
... Inspired from the leishmanicidal and antibacterial potential of the fractions obtained from the crude extract of Olea ferruginea stem, the anti-leishmanial ethyl acetate fraction was subjected to chromatographic separation, leading to the isolation of a new compound ferruginan (1) and a known compound (+)- cycloolivil (2). The structures of 1 and 2 were determined by various spectroscopic techniqu ...
DOI:
10.1080/10286020.2018.1467894

4. Meta-analysis and discussion on challenges to translate Leishmania drug resistance phenotyping into the clinic

Author:
Sereno, Denis; Harrat, Zoubir; Eddaikra, Naouel
Source:
Acta tropica 2019 v.191 pp. 204-211
ISSN:
0001-706X
Subject:
promastigotes,   etc   ; Leishmania; amastigotes; antibiotic resistance; genetic markers; guidelines; meta-analysis; microorganisms; phenotype;     Show all 9 Subjects
Abstract:
... Antimicrobial resistance (AMR) threatens the prevention and treatment of infections caused by a large range of microorganisms. Leishmania is not an exception and treatment failure due to drug-resistant organisms is increasingly reported. Currently, no molecular methods and marker are validated to track drug-resistant organism and antimicrobial susceptibility tests are roughly not amenable to a cli ...
DOI:
10.1016/j.actatropica.2019.01.009

5. Leishmania Viannia guyanensis

Author:
Olivier, Martin; Menendez, Aida Minguez; Fernandez-Prada, Christopher
Source:
Trends in parasitology 2019
ISSN:
1471-4922
Subject:
promastigotes,   etc   ; Leishmania; Leishmania RNA virus; Lutzomyia; amastigotes; exosomes; females; hematophagy; leishmaniasis; parasites; tissues; Argentina; United States;     Show all 13 Subjects
Abstract:
... Leishmania of the Viannia subgenus, including Leishmania Viannia guyanensis, is the agent responsible for cutaneous and mucocutaneous leishmaniasis (CL and MCL) in the Americas from the US to Argentina. 48,000 new cases of Cl and MCL are reported yearly, among which 1/10 are associated with L. V. guyanensis infection transmitted by female Lutzomyia sandflies during the blood meal. Inoculated metac ...
DOI:
10.1016/j.pt.2019.06.008

6. Shared species of crocodilian trypanosomes carried by tabanid flies in Africa and South America, including the description of a new species from caimans, Trypanosoma kaiowa n. sp.

Author:
Fermino, Bruno R.; Paiva, Fernando; Viola, Laerte B.; Rodrigues, Carla M. F.; Garcia, Herakles A.; Campaner, Marta; Takata, Carmen S. A.; Sheferaw, Desie; Kisakye, John J.; Kato, Agapitus; Jared, Carlos A. G. S.; Teixeira, Marta M. G.; Camargo, Erney P.
Source:
Parasites & vectors 2019 v.12 no.1 pp. 225
ISSN:
1756-3305
Subject:
promastigotes,   etc   ; Glossina; Hirudinea; Miocene epoch; Osteolaemus tetraspis; Tabanidae; Trypanosoma; crocodiles; epimastigotes; insects; microscopy; new species; phylogeny; wetlands; Africa; South America;     Show all 16 Subjects
Abstract:
... BACKGROUND: The genus Trypanosoma Gruby, 1843 is constituted by terrestrial and aquatic phylogenetic lineages both harboring understudied trypanosomes from reptiles including an increasing diversity of crocodilian trypanosomes. Trypanosoma clandestinus Teixeira & Camargo, 2016 of the aquatic lineage is transmitted by leeches to caimans. Trypanosoma grayi Novy, 1906 of the terrestrial lineage is tr ...
DOI:
10.1186/s13071-019-3463-2

7. Anti-Leishmania and cytotoxic activities of perillaldehyde epoxide synthetic positional isomers

Author:
Keesen, Tatjana Souza Lima; da Silva, Larisse Virgolino; da Câmara Rocha, Juliana; Andrade, Luciana Nalone; Lima, Tamires Cardoso; de Sousa, Damião Pergentino
Source:
Natural product research 2019 v.33 no.17 pp. 2536-2540
ISSN:
1478-6427
Subject:
promastigotes,   etc   ; Leishmania donovani; cytotoxicity; essential oils; inhibitory concentration 50; leishmaniasis; mononuclear leukocytes; monoterpenoids; positional isomers; public health; zoonoses;     Show all 11 Subjects
Abstract:
... Leishmaniasis belongs to a complex of zoonotic disease caused by protozoa of the genus Leishmania and is considered a major public health problem. Several essential oil chemical components have inhibitory effect against protozoa, including Leishmania donovani. Thus, the aim of this study was to evaluate for the first time the anti-Leishmania activity of two p-menthane monoterpene isomers (EPER-1: ...
DOI:
10.1080/14786419.2018.1448813

8. Dipeptidyl nitrile derivatives have cytostatic effects against Leishmania spp. promastigotes

Author:
Quilles, José C.; Tezuka, Daiane Y.; Lopes, Carla D.; Ribeiro, Fernanda L.; Laughton, Charles A.; de Albuquerque, Sérgio; Montanari, Carlos A.; Leitão, Andrei
Source:
Experimental parasitology 2019 v.200 pp. 84-91
ISSN:
0014-4894
Subject:
promastigotes,   etc   ; Leishmania amazonensis; Leishmania infantum; cell cycle checkpoints; cysteine proteinases; cytotoxicity; macrophages; mechanism of action; nitriles; parasites; proteolysis; therapeutics;     Show all 12 Subjects
Abstract:
... Cysteine proteases are involved in critical cell processes to the protozoa from Leishmania genus, and their inhibition is a therapeutic alternative to treat the disease. In this work, derivatives of dipeptidyl nitriles acting as reversible covalent inhibitors of cysteine proteases were studied as cytostatic agents. The proteolytic activity inside the living and lysed parasite cells was quantified ...
DOI:
10.1016/j.exppara.2019.04.001

9. Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds

Author:
Borba, Joyce V.B.; Silva, Arthur C.; Ramos, Pablo I.P.; Grazzia, Nathalia; Miguel, Danilo C.; Muratov, Eugene N.; Furnham, Nicholas; Andrade, Carolina H.
Source:
Computational and Structural Biotechnology Journal 2019
ISSN:
2001-0370
Subject:
promastigotes,   etc   ; Leishmania braziliensis; Leishmania infantum; amastigotes; antileishmanials; bioinformatics; biotechnology; leishmaniasis; new drugs; parasites; prioritization; protein kinases; toxicity; tropical diseases;     Show all 14 Subjects
Abstract:
... Leishmaniasis is a neglected tropical disease caused by parasites of the genus Leishmania (NTD) endemic in 98 countries. Although some drugs are available, current treatments deal with issues such as toxicity, low efficacy, and emergence of resistance. Therefore, there is an urgent need to identify new targets for the development of new antileishmanial drugs. Protein kinases (PKs), which play an e ...
DOI:
10.1016/j.csbj.2019.02.005

10. Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate

Author:
Patino, Luz H.; Muskus, Carlos; Ramírez, Juan David
Source:
Parasites & vectors 2019 v.12 no.1 pp. 348
ISSN:
1756-3305
Subject:
promastigotes,   etc   ; Leishmania amazonensis; antimony; autophagy; drug resistance; drugs; fatty acids; gene expression regulation; genes; metabolism; parasites; phenotype; proteins; sequence analysis; stress response; transcription (genetics); transcriptome; transcriptomics;     Show all 18 Subjects
Abstract:
... BACKGROUND: In the last decade, resistance to antimonials has become a serious problem due to the emergence of drug-resistant strains. Therefore, understanding the mechanisms used by Leishmania parasites to survive under drug pressure is essential, particularly for species of medical-veterinary importance such as L. amazonensis. METHODS: Here, we used RNA-seq technology to analyse transcriptome pr ...
DOI:
10.1186/s13071-019-3603-8

11. In vitro growth characteristics and morphological differentiation of Leishmania martiniquensis promastigotes in different culture media

Author:
Siripattanapipong, Suradej; Boontanom, Parima; Leelayoova, Saovanee; Mungthin, Mathirut; Tan-ariya, Peerapan
Source:
Acta tropica 2019 v.197 pp. 105039
ISSN:
0001-706X
Subject:
promastigotes,   etc   ; Human immunodeficiency virus; Leishmania; culture media; cutaneous leishmaniasis; epidemiological studies; health policy; humans; infectious diseases; parasites; patients; viability; visceral leishmaniasis; Martinique; Thailand;     Show all 15 Subjects
Abstract:
... The protozoan hemoflagellate, Leishmania martiniquensis, is the causative agent of cutaneous and visceral leishmaniasis among humans. This parasite was first isolated from an autochthonous case of cutaneous leishmaniasis in Martinique Island (French West Indies) in 1995 and its taxonomical position was later established in 2002. At present, the emergence of this globally infectious disease caused ...
DOI:
10.1016/j.actatropica.2019.05.030

12. Natural compounds from plants controlling leishmanial growth via DNA damage and inhibiting trypanothione reductase and trypanothione synthetase: an in vitro and in silico approach

Author:
Mehwish, Shaila; Khan, Huma; Rehman, Ashfaq Ur; Khan, Asif Ullah; Khan, Mubarak Ali; Hayat, Obaid; Ahmad, Mansoor; Wadood, Abdul; Ullah, Nazif
Source:
3 Biotech 2019 v.9 no.8 pp. 303
ISSN:
2190-572X
Subject:
promastigotes,   etc   ; DNA; DNA damage; Leishmania tropica; catalytic activity; enzymes; erythrocytes; gallic acid; humans; inhibitory concentration 50; ligands; lupeol; mechanism of action; molecular dynamics; prediction; quercetin; rutin;     Show all 17 Subjects
Abstract:
... In the present study, four different natural compounds including quercetin, gallic acid, rutin, and lupeol were studied for their anti-leishmanial potentials with anticipated mechanism of action through in vitro and in silico approaches. Results showed that rutin was exceedingly active (IC₅₀; 91.2 µg/ml) against the promastigote form of Leishmania tropica compared to quercetin (IC₅₀; 182.3 µg/ml), ...
DOI:
10.1007/s13205-019-1826-1

13. Leishmania infantum nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) B-domain: Antibody antiproliferative effect on the promastigotes and IgG subclass responses in canine visceral leishmaniasis

Author:
Maia, Ana Carolina Ribeiro Gomes; Porcino, Gabriane Nascimento; Faria-Pinto, Priscila; Mendes, Túlio Vieira; Antinarelli, Luciana Maria Ribeiro; Coimbra, Elaine Soares; Reis, Alexandre Barbosa; Juliano, Luiz; Juliano, Maria Aparecida; Marques, Marcos José; Vasconcelos, Eveline Gomes
Source:
Veterinary parasitology 2019 v.271 pp. 38-44
ISSN:
0304-4017
Subject:
promastigotes,   etc   ; Leishmania infantum; antiserum; confocal laser scanning microscopy; dogs; enzyme-linked immunosorbent assay; enzymes; epitopes; flagellum; immunocytochemistry; immunoglobulin G; immunotherapy; nucleosides; polyclonal antibodies; synthetic peptides; visceral leishmaniasis;     Show all 16 Subjects
Abstract:
... A nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1) was identified on the surface, flagellum and kinetoplast from L. infantum promastigotes by immunocytochemistry and confocal laser scanning microscopy, using immune sera that recognized specifically the B domain of NTPDase 1 and produced against synthetic peptides (LbB1LJ and LbB2LJ) derived from this domain. The polyclonal antibodies had e ...
DOI:
10.1016/j.vetpar.2019.06.004

14. Axenic amastigote cultivation and in vitro development of Leishmania orientalis

Author:
Chanmol, Wetpisit; Jariyapan, Narissara; Somboon, Pradya; Bates, Michelle D.; Bates, Paul A.
Source:
Parasitology research 2019 v.118 no.6 pp. 1885-1897
ISSN:
0932-0113
Subject:
promastigotes,   etc   ; Leishmania; amastigotes; gentamicin; human cell lines; humans; in vitro culture; leishmaniasis; macrophages; monocytes; new species; nucleases; pH; parasites; pathogenicity; sulfates; temperature; urine; vitamins; Thailand;     Show all 20 Subjects
Abstract:
... Leishmania (Mundinia) orientalis is a recently described new species that causes leishmaniasis in Thailand. To facilitate characterization of this new species, an in vitro culture system to generate L. orientalis axenic amastigotes was developed. In vitro culture conditions of the axenic culture-derived amastigotes were optimized by manipulation of temperature and pH. Four criteria were used to ev ...
DOI:
10.1007/s00436-019-06311-z

15. Farnesyl pyrophosphate synthase is essential for the promastigote and amastigote stages in Leishmania major

Author:
Mukherjee, Sumit; Basu, Somrita; Zhang, Kai
Source:
Molecular and biochemical parasitology 2019 v.230 pp. 8-15
ISSN:
0166-6851
Subject:
promastigotes,   etc   ; Leishmania major; amastigotes; biosynthesis; catalytic activity; cutaneous leishmaniasis; dolichols; drugs; enzymes; genetic analysis; mice; moieties; mutants; nitrogen; selection pressure; sterols; ubiquinones;     Show all 17 Subjects
Abstract:
... Isoprenoid synthesis provides a diverse class of biomolecules including sterols, dolichols, ubiquinones and prenyl groups. The enzyme farnesyl pyrophosphate synthase (FPPS) catalyzes the formation of farnesyl pyrophosphate, a key intermediate for the biosynthesis of all isoprenoids. In Leishmania, FPPS is considered the main target of nitrogen containing bisphosphonates, yet the essentiality of th ...
DOI:
10.1016/j.molbiopara.2019.03.001

16. Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis

Author:
Cavalcanti de Queiroz, Aline; Alves, Marina Amaral; Barreiro, Eliezer Jesus; Lima, Lídia Moreira; Alexandre-Moreira, Magna Suzana
Source:
Experimental parasitology 2019 v.201 pp. 57-66
ISSN:
0014-4894
Subject:
promastigotes,   etc   ; Leishmania amazonensis; Leishmania braziliensis; amastigotes; antileishmanial properties; antileishmanials; apoptosis; autophagy; cell cycle; dermis; ears; leishmaniasis; macrophages; mice; parasite load; parasites; peptides; therapeutics;     Show all 18 Subjects
Abstract:
... In the present study, we investigated the in vitro and in vivo leishmanicidal activity of synthetic compounds, containing a semicarbazone scaffold as a peptide mimetic framework. The leishmanicidal effect against amastigotes of Leishmania amazonensis was also evaluated at concentration of 100 μM–0.01 nM. The derivatives 2e, 2f, 2g and 1g, beyond the standards miltefosine and pentamidine, significa ...
DOI:
10.1016/j.exppara.2019.04.003

17. Ximenia americana L. enhances the antibiotic activity and inhibit the development of kinetoplastid parasites

Author:
de Menezes, Irwin Rose Alencar; da Costa, Roger Henrique Sousa; Augusti Boligon, Aline; Rolón, Miriam; Coronel, Cathia; Vega, Celeste; Melo Coutinho, Henrique Douglas; da Costa, Maria Socorro; Tintino, Saulo Relison; Silva Pereira, Raimundo Luiz; de Albuquerque, Thais Rodrigues; da Silva Almeida, Jackson Roberto Guedes; Quintans-Júnior, Lucindo José
Source:
Comparative immunology, microbiology, and infectious diseases 2019 v.64 pp. 40-46
ISSN:
0147-9571
Subject:
promastigotes,   etc   ; Leishmania infantum; Trypanosoma cruzi; Ximenia americana; antibacterial properties; antibiotics; antiparasitic agents; bacteria; bacterial infections; bark; caffeic acid; chemical composition; cytotoxicity; fibroblasts; leishmaniasis; mortality; parasites; synergism; therapeutics;     Show all 19 Subjects
Abstract:
... The objective of this work was evaluate the cytotoxic, leishmanicidal and tripanocidal activity, as well as to evaluate its antimicrobial and modulatory activity in association with different antibiotics of the hydroethanolic extract of the Ximenia Americana stem bark (EHXA).In vitro tests against Trypanosoma cruzi, Leishmania sp. and citotoxicity were performed. The evaluation of the antibacteria ...
DOI:
10.1016/j.cimid.2019.02.007

18. Metacyclogenesis of Leishmania (Viannia) guyanensis: a comprehensive study of the main transformation features in axenic culture and purification of metacyclic promastigotes by negative selection with Bauhinia purpurea lectin

Author:
Mendes, Bárbara Pinheiro; da Silva, Ildefonso Alves; DaMata, Jarina Pena; Castro-Gomes, Thiago; Vieira, Leda Quercia; Ribeiro-Dias, Fátima; Horta, Maria Fátima
Source:
Parasitology 2019 v.146 no.6 pp. 716-727
ISSN:
1469-8161
Subject:
promastigotes,   etc   ; Bauhinia purpurea; Leishmania guyanensis; axenic culture; body size; carbohydrates; complement; cutaneous leishmaniasis; flagellum; humans; lectins; macrophages; metacyclic forms; models; parasites; pathogenicity;     Show all 16 Subjects
Abstract:
... Leishmania (Viannia) guyanensis is one species that causes cutaneous leishmaniasis in the New World. The incidence of infections with this parasite is probably underestimated and few studies exist on this species, despite its epidemiological importance. In particular, there are no studies concerning L. guyanensis metacyclogenesis and no technique for obtaining metacyclic promastigotes for this spe ...
DOI:
10.1017/S0031182018002111

19. Potential of Pluronics® P-123 and F-127 as nanocarriers of anti-Leishmania chemotherapy

Author:
Oyama, Jully; Lera-Nonose, Daniele Stéfanie Sara Lopes; Ramos-Milaré, Áquila Carolina Fernandes Herculano; Padilha Ferreira, Fabiana Borges; de Freitas, Camila Fabiano; Caetano, Wilker; Hioka, Noboru; Silveira, Thaís Gomes Verzignassi; Lonardoni, Maria Valdrinez Campana
Source:
Acta tropica 2019 v.192 pp. 11-21
ISSN:
0001-706X
Subject:
promastigotes,   etc   ; Leishmania amazonensis; adverse effects; amastigotes; culture media; cutaneous leishmaniasis; cytotoxicity; death; humans; macrophages; membrane potential; micelles; mitochondrial membrane; nanocarriers; nanoparticles; parasites; photochemotherapy; photosensitizing agents; survival rate;     Show all 19 Subjects
Abstract:
... Leishmaniasis is a neglected disease and drugs approved for its treatment often lead to abandonment, failure of therapy and even death. Photodynamic therapy (PDT) has been shown to be a promising, non-invasive and selective for a target region without requiring high-cost technology. Usually, it is employed a photosensitizing agent (PS) incorporated into nanoparticles (NP). Pluronics® P-123 and F-1 ...
DOI:
10.1016/j.actatropica.2019.01.008

20. Repurposing azole antifungals into antileishmanials: Novel 3-triazolylflavanones with promising in vitro antileishmanial activity against Leishmania major

Author:
Keighobadi, Masoud; Emami, Saeed; Fakhar, Mahdi; Shokri, Azar; Mirzaei, Hassan; Hosseini Teshnizi, Saeed
Source:
Parasitology international 2019 v.69 pp. 103-109
ISSN:
1383-5769
Subject:
promastigotes,   etc   ; Leishmania major; active sites; amastigotes; antileishmanial properties; antileishmanials; apoptosis; drugs; enzymes; flavanones; fluconazole; fungi; heme; macrophages; mechanism of action; moieties; parasites; prototypes; sterols; toxicity; toxicity testing;     Show all 21 Subjects
Abstract:
... Previously, we have described a series of azole antifungals namely 3-(1,2,4-triazol-1-yl)flavanones (TFs) containing an N-(phenethyl)azole framework required for sterol 14α-demethylase (CYP51) inhibitory activity. Similar mechanism of action of azoles in fungi and protozoan parasites prompted us to investigate the potential effects of TFs against promastigote and amastigote forms of Leishmania maj ...
DOI:
10.1016/j.parint.2018.12.006