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1. Micron-sized silica particles in wastewater influenced the distribution of organic matters in sludge and their anaerobic degradation

Author:
Chen, Sisi; Dong, Bin; Yang, Dianhai; Li, Ning; Dai, Xiaohu
Source:
Journal of hazardous materials 2020 v.393 pp. 122340
ISSN:
0304-3894
Subject:
protein degradation,   etc   ; methane production; polysaccharides; protein content; protein secondary structure; sewage sludge; silica; wastewater; China;     Show all 9 Subjects
Abstract:
... The influence of micron-sized silica particles on the distribution of organic matters in sludge and anaerobic degradation of macromolecular organic components (MOCs) in sludge was investigated. With the addition of micron-sized particles in the influent (VS/TS decreased gradually from 90.46 ± 0.21 % to 33.36 ± 0.17 %), the protein degradation percentage was significantly promoted while the polysac ...
DOI:
10.1016/j.jhazmat.2020.122340

2. Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery

Author:
Madden, Sarah K.; Itzhaki, Laura S.
Source:
Biochimica et biophysica acta 2020 v.1868 no.7 pp. 140405
ISSN:
1570-9639
Subject:
protein degradation,   etc   ; Lewis acids; drugs; mechanism of action; oxidative stress; proteins; therapeutics;     Show all 7 Subjects
Abstract:
... The proteins Keap1 and Nrf2 together act as a cytoprotective mechanism that enables cells to overcome electrophilic and oxidative stress. Research has shown that manipulating this system by modulating the Keap1-Nrf2 interaction either through inhibition at the binding interface or via the covalent modification of Keap1 could provide a powerful therapeutic strategy for a range of diseases. However, ...
DOI:
10.1016/j.bbapap.2020.140405

3. Utilization of i-TRAQ technology to determine protein modifications in pork soup in response to addition of salt

Author:
Zhu, Chaozhi; Zhao, Gaiming; Cui, Wenming; Li, Shanshan; Yu, Xiaoling; Zhang, Qiuhui
Source:
Subtropical plant science 2020 v.88 pp. 103453
ISSN:
0889-1575
Subject:
protein degradation,   etc   ; collagen; cooking; nutrition; peptides; pork; protein composition; proteolysis; soups;     Show all 9 Subjects
Abstract:
... During cooking of traditional Chinese meat-based soups, the presence or absence of salt creates a very different environment for the product during the cooking process, with potential nutritional effects. The protein profiles of soup included 2 % salt (Treated) and soup without salt (Control) were determined and showed significant proteolysis in the treated group. Proteolytic index of treated was ...
DOI:
10.1016/j.jfca.2020.103453

4. The Fusarium mycotoxin, 2-Amino-14,16-dimethyloctadecan-3-ol (AOD) induces vacuolization in HepG2 cells

Author:
Solhaug, A; Torgersen, ML; Holme, JA; Wiik-Nilsen, J; Thiede, B; Eriksen, GS
Source:
Toxicology 2020 v.433-434 pp. 152405
ISSN:
0300-483X
Subject:
protein degradation,   etc   ; Fusarium avenaceum; autophagy; biosynthesis; chloroquine; endosomes; fungi; hepatocytes; lysosomes; models; mycotoxins; proteomics; sphingolipids; vacuoles;     Show all 14 Subjects
Abstract:
... The mycotoxin 2-Amino-14,16-dimethyloctadecan-3-ol (AOD) has been isolated from cultures of the fungus Fusarium avenaceum, one of the most prevalent Fusarium species. AOD is an analogue of sphinganine and 1-deoxysphinganine, important intermediates in the de novo biosynthesis of cellular sphingolipids. Here we studied cellular effects of AOD using the human liver cell line HepG2 as a model system. ...
DOI:
10.1016/j.tox.2020.152405

5. Mutations of key substrate binding residues of leishmanial peptidase T alter its functional and structural dynamics

Author:
Bhat, Saleem Yousuf; Qureshi, Insaf Ahmed
Source:
Biochimica et biophysica acta 2020 v.1864 no.1 pp. 129465
ISSN:
0304-4165
Subject:
protein degradation,   etc   ; active sites; alanine; antileishmanials; hydrolysis; mutation; oligopeptides; structural biology; substrate specificity; tripeptide aminopeptidase;     Show all 10 Subjects
Abstract:
... M20 aminopeptidases, such as Peptidase T (PepT), are implicated in the hydrolysis of oligopeptides during the terminal stages of protein degradation pathway to maintain turnover. Therefore, specific inhibition of PepT bores well for the development of novel next-generation antileishmanials. This work describes the metal dependence, substrate preferences and inhibition of PepT, and demonstrates in ...
DOI:
10.1016/j.bbagen.2019.129465

6. Protein degradation of black carp (Mylopharyngodon piceus) muscle during cold storage

Author:
Bao, Yulong; Wang, Keyu; Yang, Hongxu; Regenstein, Joe M.; Ertbjerg, Per; Zhou, Peng
Source:
Food chemistry 2020 v.308 pp. 125576
ISSN:
0308-8146
Subject:
protein degradation,   etc   ; Mylopharyngodon piceus; cold storage; crystals; enzyme activity; ice; muscles; myofibrillar proteins; myosin; proteinases; proteomics; sarcoplasmic reticulum; storage temperature;     Show all 13 Subjects
Abstract:
... This study investigated the effects of cold storage at different temperatures (4, −0.5, −3, and −20 °C) on protein degradation and its relationship to structural changes of black carp muscle. At −0.5 and 4 °C, major structural changes occurred, including the formation of gaps between myofibers and myofibrils, breakage of myofibrils and myofibers, and degradation of sarcoplasmic reticulum. Gel-base ...
DOI:
10.1016/j.foodchem.2019.125576

7. Influence of phosphates and pH value on white efflorescence formation on dry fermented sausages

Author:
Hilbig, Jonas; Hartlieb, Katrin; Herrmann, Kurt; Weiss, Jochen; Gibis, Monika
Source:
European food research & technology 2020 v.246 no.3 pp. 471-484
ISSN:
1438-2377
Subject:
protein degradation,   etc   ; alginates; calcium; cations; chelating agents; citrates; citric acid; creatine; fermented sausages; gels; lactic acid; magnesium; pH; polyphosphates; solubility;     Show all 15 Subjects
Abstract:
... The effect of chelators added to the gel of the alginate casing of dry fermented sausages on the white efflorescence formation was investigated. For this purpose, the chelators were added in different concentrations (0.8–2.3%) to the alginate gel before the co-extrusion of the sausage. The applied chelators were the polyphosphate P69, citrate, citric acid, and the mixture of di- and polyphosphates ...
DOI:
10.1007/s00217-019-03415-9

8. Peroxisomes: versatile organelles with diverse roles in plants

Author:
Pan, Ronghui; Liu, Jun; Wang, Saisai; Hu, Jianping
Source:
Thenew phytologist 2020 v.225 no.4 pp. 1410-1427
ISSN:
0028-646X
Subject:
protein degradation,   etc   ; biochemical pathways; eukaryotic cells; growth and development; homeostasis; macroautophagy; metabolism; peroxisomes; protein content; protein transport; proteome; solutes;     Show all 12 Subjects
Abstract:
... Peroxisomes are small, ubiquitous organelles that are delimited by a single membrane and lack genetic material. However, these simple‐structured organelles are highly versatile in morphology, abundance and protein content in response to various developmental and environmental cues. In plants, peroxisomes are essential for growth and development and perform diverse metabolic functions, many of whic ...
DOI:
10.1111/nph.16134

9. Efficient accumulation of high-value bioactive substances by carbon to nitrogen ratio regulation in marine microalgae Porphyridium purpureum

Author:
Li, Shaohua; Ji, Liang; Chen, Cheng; Zhao, Shuxin; Sun, Meng; Gao, Zhengquan; Wu, Haizhen; Fan, Jianhua
Source:
Bioresource technology 2020 v.309 pp. 123362
ISSN:
0960-8524
Subject:
protein degradation,   etc   ; Porphyridium; bioactive compounds; biomass; carbon nitrogen ratio; cost effectiveness; growth retardation; metabolites; microalgae; nitrogen; omega-6 fatty acids; polysaccharides; polyunsaturated fatty acids; secretion;     Show all 14 Subjects
Abstract:
... An efficient biomass and high-value bioactive substances production strategy was developed for unicellular microalgae Porphyridium purpureum. We studied the optimal culture method and metabolites accumulation under different C/N conditions, and further proposed methods to increase the yield under high C/N ratio. The highest biomass reached 16.24 g/L with ASW medium by mixotrophy. High C/N ratio an ...
DOI:
10.1016/j.biortech.2020.123362

10. Rutin protects Huntington's disease through the insulin/IGF1 (IIS) signaling pathway and autophagy activity: Study in Caenorhabditis elegans model

Author:
Cordeiro, Larissa Marafiga; Machado, Marina Lopes; da Silva, Aline Franzen; Obetine Baptista, Fabiane Bicca; da Silveira, Tássia Limana; Soares, Felix Alexandre Antunes; Arantes, Leticia Priscilla
Source:
Food and chemical toxicology 2020 v.141 pp. 111323
ISSN:
0278-6915
Subject:
protein degradation,   etc   ; Caenorhabditis elegans; animal models; antioxidant activity; apples; autophagy; buckwheat; cognition; disease models; insulin; longevity; muscles; mutants; neurodegenerative diseases; protective effect; rutin; sensory neurons; signal transduction; toxicity;     Show all 19 Subjects
Abstract:
... Huntington's disease (HD) is inherited neurodegenerative disease, it is characterized by excessive motor movements and cognitive and emotional deficits. HD is caused by an abnormally long polyglutamine (polyQ) expansion in the huntingtin (Htt) protein, which confers toxic functions to mutant Htt leading to neurodegeneration. Rutin is a flavonoid found in plants, buckwheat, some teas and also in ap ...
DOI:
10.1016/j.fct.2020.111323

11. Stoichiometry of Anaerobic Protein Fermentation

Author:
Tepari, Emmanuel Andrew; Nakhla, George; Idris, Munirat; Haroun, Basem M.; Hafez, Hisham
Source:
Biochemical engineering journal 2020 v.158 pp. 107564
ISSN:
1369-703X
Subject:
protein degradation,   etc   ; activated sludge; arginine; bovine serum albumin; fermentation; models; municipal wastewater; pH; proline; propionic acid; stoichiometry; valeric acid; volatile fatty acids; wastewater treatment;     Show all 14 Subjects
Abstract:
... The stoichiometric reactions that characterize protein fermentation during anaerobic wastewater treatment were investigated using bovine serum albumin (BSA) as the model protein. A methodology was developed to describe anaerobic protein degradation to volatile fatty acids (VFAs) using a single reaction step based on the dominant amino acid fermentation pathways. The importance of this work stems f ...
DOI:
10.1016/j.bej.2020.107564

12. Transcriptome alterations in female Daphnia (Daphnia magna) exposed to 17β-estradiol

Author:
Zheng, Yao; Yuan, Julin; Gu, Zhimin; Yang, Guang; Li, Tian; Chen, Jiazhang
Source:
Environmental pollution 2020 v.261 pp. 114208
ISSN:
0269-7491
Subject:
protein degradation,   etc   ; Daphnia magna; RNA transport; active ingredients; disease prevention; estradiol; females; gene expression regulation; immune system; metabolism; neoplasms; time series analysis; toxicity; transcription (genetics); transcriptome;     Show all 15 Subjects
Abstract:
... The molecular mechanism of evaluating 17β-estradiol (E₂)-induced toxicity in female Daphnia magna has not been determined. In this study, the transcriptome of D. magna was analyzed after exposure to three different concentrations (0, 10, and 100 ng L⁻¹) of E₂ at 3, 6, and 12 h. The results showed 351–17,221 significantly up-regulated and 505–10,282 significantly down-regulated genes (P < 0.05). Ov ...
DOI:
10.1016/j.envpol.2020.114208

13. Calcium effect on microbial activity and biomass aggregation during anaerobic digestion at high salinity

Author:
Gagliano, Maria Cristina; Sudmalis, Dainis; Temmink, Hardy; Plugge, Caroline M.
Source:
New biotechnology 2020 v.56 pp. 114-122
ISSN:
1871-6784
Subject:
protein degradation,   etc   ; Methanosaeta; anaerobic digestion; biomass; blood serum; bottles; calcium; cell communication; chemical oxygen demand; granules; hydrolysis; methane production; methanogens; microbial activity; salinity; sodium;     Show all 16 Subjects
Abstract:
... The potential effect of different Ca²⁺ additions (150, 300, 450, 600 and 1000 mg/L) on microbial activity and aggregation, during anaerobic digestion at moderate (8 g/L Na⁺) and high salinity (20 g/L Na⁺) has been investigated. Batch tests were carried out in duplicate serum bottles and operated for 30 days at 37 °C. At 8 g/L Na⁺, methanogenic activity and protein degradation were comparable from ...
DOI:
10.1016/j.nbt.2020.01.001

14. Inhibition of melanosis and microbial growth in Pacific white shrimp (Litopenaeus vannamei) using high CO2 modified atmosphere packaging

Author:
Kimbuathong, Netchanok; Leelaphiwat, Pattarin; Harnkarnsujarit, Nathdanai
Source:
Food chemistry 2020 v.312 pp. 126114
ISSN:
0308-8146
Subject:
protein degradation,   etc   ; Enterobacteriaceae; Litopenaeus vannamei; carbon dioxide; catechol oxidase; firmness; headspace analysis; image analysis; lipid peroxidation; melanosis; microbial growth; modified atmosphere packaging; oxygen; plate count; synergism; trimethylamine;     Show all 16 Subjects
Abstract:
... Preserving quality of crustaceans requires efficient modified atmosphere packaging (MAP). Effects of CO₂ (20%–80%) on quality and melanosis in chilled Pacific white shrimp (Litopenaeus vannamei) under O₂ concentrations of 5 and 15% were investigated. Increased headspace CO₂ and lipid oxidation contributed to loss of firmness due to protein degradation. Image analysis indicated increased degree of ...
DOI:
10.1016/j.foodchem.2019.126114

15. 17β-estradiol attenuates rat articular chondrocyte injury by targeting ASIC1a-mediated apoptosis

Author:
Song, Su-Jing; Tao, Jing-Jing; Li, Shu-Fang; Qian, Xue-Wen; Niu, Ruo-Wen; Wang, Cong; Zhang, Yi-Hao; Chen, Yong; Wang, Ke; Zhu, Fei; Zhu, Chuan-Jun; Ma, Gang-Gang; Yang-Yang,; Peng, Xiao-Qing; Zhou, Ren-Peng; Chen, Fei-Hu
Source:
Molecular and cellular endocrinology 2020 v.505 pp. 110742
ISSN:
0303-7207
Subject:
protein degradation,   etc   ; apoptosis; cartilage; chondrocytes; estradiol; etiology; inflammation; ion channels; metabolism; mitochondria; models; ovariectomy; pathogenesis; protective effect; protein content; rheumatoid arthritis;     Show all 16 Subjects
Abstract:
... Epidemiological evidence suggests that the etiology and pathogenesis of rheumatoid arthritis (RA) are closely associated with estrogen metabolism and deficiency. Estrogen protects against articular damage. Estradiol replacement therapy ameliorates local inflammation and knee joint swelling in ovariectomized models of RA. The mechanistic basis for the protective role of 17β-estradiol (17β-E2) is po ...
DOI:
10.1016/j.mce.2020.110742

16. 6-OH-BDE-47 exposure-induced Parkinson’s disease pathology in Sprague Dawley rat

Author:
Ji, Fenfen; Zhu, Zhou; Zhang, Mengtao; Zhang, Huan; Zhu, Lin; Cai, Xiaodong; Liu, Wenlan; Song, Juxian; Li, Min; Cai, Zongwei
Source:
The Science of the total environment 2020 v.711 pp. 135184
ISSN:
0048-9697
Subject:
protein degradation,   etc   ; Parkinson disease; Western blotting; animal diseases; autophagy; brain; dopamine; laboratory animals; metabolites; neurons; neurotoxicity; neurotoxins; pollutants; proteomics; rats; risk; tyrosine 3-monooxygenase; ubiquitination;     Show all 18 Subjects
Abstract:
... 6-Hydroxy-BDE-47 (6-OH-BDE-47) is an important in vivo metabolite derived from 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47), a ubiquitous environmental pollutant. The chemical has been widely detected in environmental and biological samples. However, as a potential neurotoxin, whether 6-OH-BDE-47 could promote the development of typical neurodegenerative diseases such as Parkinson’s disease (PD) is ...
DOI:
10.1016/j.scitotenv.2019.135184

17. Natural antioxidants' effects on endoplasmic reticulum stress-related diseases

Author:
Reyes-Fermín, Laura María; Aparicio-Trejo, Omar Emiliano; Avila-Rojas, Sabino Hazael; Gómez-Sierra, Tania; Martínez-Klimova, Elena; Pedraza-Chaverri, José
Source:
Food and chemical toxicology 2020 v.138 pp. 111229
ISSN:
0278-6915
Subject:
protein degradation,   etc   ; antioxidants; cell death; cell viability; diabetes; disease control; endoplasmic reticulum; heart; homeostasis; kidneys; liver; nervous system diseases; oxidative stress; proteins; unfolded protein response;     Show all 15 Subjects
Abstract:
... Endoplasmic reticulum (ER) stress is a normal molecular process induced by the over-accumulation of misfolded or unfolded proteins. ER stress induces the unfolded protein response (UPR), which reduces global protein synthesis, increases ER capacity and protein degradation, to restart ER homeostasis, allowing cell survival. However, the over-induction of UPR can also trigger inflammatory processes, ...
DOI:
10.1016/j.fct.2020.111229

18. The response of the melanized yeast Exophiala dermatitidis to gamma radiation exposure

Author:
Schultzhaus, Zachary; Romsdahl, Jillian; Chen, Amy; Tschirhart, Tanya; Kim, Seongwon; Leary, Dagmar; Wang, Zheng
Source:
Environmental microbiology 2020 v.22 no.4 pp. 1310-1326
ISSN:
1462-2912
Subject:
protein degradation,   etc   ; DNA repair; Exophiala dermatitidis; cell viability; environmental factors; gamma radiation; melanin; melanization; models; nutrient availability; radiation resistance; transcriptomics; yeasts;     Show all 13 Subjects
Abstract:
... The melanized yeast Exophiala dermatitidis is resistant to many environmental stresses and is used as a model for understanding the diverse roles of melanin in fungi. Here, we describe the extent of resistance of E. dermatitidis to acute γ‐radiation exposure and the major mechanisms it uses to recover from this stress. We find that melanin does not protect E. dermatitidis from γ‐radiation. Instead ...
DOI:
10.1111/1462-2920.14936

19. The stability and antiapoptotic activity of Bm30K‐3 can be improved by lysine acetylation in the silkworm, Bombyx mori

Author:
Ma, Yafei; Wu, Chengcheng; Liu, Jiahan; Liu, Yue; Lv, Jiao; Sun, Zihan; Wang, Dan; Jiang, Caiying; Sheng, Qing; You, Zhengying; Nie, Zuoming
Source:
Archives of insect biochemistry and physiology 2020 v.103 no.4 pp. e21649
ISSN:
0739-4462
Subject:
protein degradation,   etc   ; Bombyx mori; acetylation; apoptosis; enzyme inhibitors; hydrogen peroxide; lysine; nutrition; post-translational modification; proteasome endopeptidase complex; silkworms; storage proteins; tandem mass spectrometry;     Show all 13 Subjects
Abstract:
... Acetylation is an important, highly conserved, and reversible post‐translational modification of proteins. Previously, we showed by nano‐HPLC/MS/MS that many nutrient storage proteins in the silkworm are acetylated. Among these proteins, most of the known 30K proteins were shown to be acetylated, including 23 acetylated 30K proteins containing 49 acetylated sites (Kac), indicating the importance o ...
DOI:
10.1002/arch.21649

20. Transgenerational biochemical effects of seawater acidification on the Manila clam (Ruditapes philippinarum)

Author:
Zhao, Liqiang; Lu, Yanan; Yang, Feng; Liang, Jian; Deng, Yuewen
Source:
The Science of the total environment 2020 v.710 pp. 136420
ISSN:
0048-9697
Subject:
protein degradation,   etc   ; Ruditapes philippinarum; acid phosphatase; adults; alkaline phosphatase; calcium; carbonate dehydratase; clams; energy; glycogen; lipids; ocean acidification; pH; parents; seawater; sodium;     Show all 16 Subjects
Abstract:
... Ocean acidification can negatively impact marine bivalves. Pivotal to projecting their fate is the ability to acclimate and adapt to shifts in seawater chemistry. Transgenerational plasticity enables marine bivalves to acclimate, yet the underlying mechanisms at different levels of biological organization remain poorly understood. Here, we performed a transgenerational experiment to understand bio ...
DOI:
10.1016/j.scitotenv.2019.136420