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1. Pro(moting) the Turnover of Gluconeogenic Enzymes by a New Branch of the N-end Rule Pathway

Author:
Dougan, David A.
Source:
Trends in biochemical sciences 2017 v.42 no.5 pp. 330-332
ISSN:
0968-0004
Subject:
protein degradation,   etc   ; enzymes; gluconeogenesis;     Show all 3 Subjects
Abstract:
... The N-end rule pathway is a set of protein degradation systems that link the in vivo stability of a protein to its N-terminal residue. A recent paper from Alexander Varshavsky’s laboratory [1] identifies a new branch of the N-end rule pathway that specifically recognizes the N-terminal Pro residue of key gluconeogenesis enzymes. ...
DOI:
10.1016/j.tibs.2017.03.006

2. Life and death of proteins after protease cleavage: protein degradation by the N‐end rule pathway

Author:
Dissmeyer, Nico; Rivas, Susana; Graciet, Emmanuelle
Source:
Thenew phytologist 2018 v.218 no.3 pp. 929-935
ISSN:
0028-646X
Subject:
protein degradation,   etc   ; cell proliferation; pathogens; proteinases; proteins; proteomics;     Show all 6 Subjects
Abstract:
... Contents Summary 929 I. Introduction: conservation and diversity of N‐end rule pathways 929 II. Defensive functions of the N‐end rule pathway in plants 930 III. Proteases and degradation by the N‐end rule pathway 930 IV. New proteomics approaches for the identification of N‐end rule substrates 932 V. Concluding remarks 932 Acknowledgements 934 References 934 SUMMARY: The N‐end rule relates the sta ...
DOI:
10.1111/nph.14619

3. Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells

Author:
Gu, Yuanxing; Zhou, Yingshan; Shi, Xinfeng; Xin, Yongping; Shan, Ying; Chen, Cong; Cao, Tong; Fang, Weihuan; Li, Xiaoliang
Source:
Archives of virology 2018 v.163 no.3 pp. 623-632
ISSN:
0304-8608
Subject:
protein degradation,   etc   ; Porcine teschovirus; autophagy; pathogens; rapamycin; viruses;     Show all 6 Subjects
Abstract:
... Autophagy is a homeostatic process that has been shown to be vital in the innate immune defense against pathogens. However, little is known about the regulatory role of autophagy in porcine teschovirus 2 (PTV-2) replication. In this study, we found that PTV-2 infection induces a strong increase in GFP-LC3 punctae and endogenous LC3 lipidation. However, PTV-2 infection did not enhance autophagic pr ...
DOI:
10.1007/s00705-017-3652-2

4. Urinary phthalate metabolite concentrations in relation to levels of circulating matrix metalloproteinases in pregnant women

Author:
Bedrosian, Leah D.; Ferguson, Kelly K.; Cantonwine, David E.; McElrath, Thomas F.; Meeker, John D.
Source:
The Science of the total environment 2018 v.613-614 pp. 1349-1352
ISSN:
0048-9697
Subject:
protein degradation,   etc   ; humans; metabolites; metalloproteinases; phthalates; pregnancy outcome; pregnant women;     Show all 7 Subjects
Abstract:
... Phthalate exposure has been shown to be associated with adverse pregnancy outcomes. However, human studies informing relevant mechanistic pathways are lacking. Experimental studies have reported that matrix metalloproteinases (MMPs), which are responsible for extracellular protein degradation, may be upregulated in response to phthalate exposure. In this exploratory study we measured urinary phtha ...
DOI:
10.1016/j.scitotenv.2017.09.244

5. Substrate Sorting by a Supercharged Nanoreactor

Author:
Azuma, Yusuke; Bader, Daniel L. V.; Hilvert, Donald
Source:
Journal of the American Chemical Society 2018 v.140 no.3 pp. 860-863
ISSN:
1520-5126
Subject:
protein degradation,   etc   ; catalysts; encapsulation; polypeptides; proteinases; proteins; substrate specificity; zwitterions;     Show all 8 Subjects
Abstract:
... Compartmentalization of proteases enables spatially and temporally controlled protein degradation in cells. Here we show that an engineered lumazine synthase protein cage, which possesses a negatively supercharged lumen, can exploit electrostatic effects to sort substrates for an encapsulated protease. This proteasome-like nanoreactor preferentially cleaves positively charged polypeptides over bot ...
DOI:
10.1021/jacs.7b11210

6. SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis

Author:
Zhao, Xinyuan; Liu, Yiming; Zhu, Ganlin; Liang, Yuanyuan; Liu, Bo; Wu, Yifan; Han, Muxi; Sun, Wenxing; Han, Yu; Chen, Gang; Jiang, Junkang
Source:
The Science of the total environment 2019 v.646 pp. 1047-1055
ISSN:
0048-9697
Subject:
protein degradation,   etc   ; acetylation; apoptosis; brain; brain damage; death; dose response; gene expression; gene expression regulation; manganese; mice; neurodegenerative diseases; neurons; neurotoxicity; protein content; rats; resveratrol; tissues;     Show all 18 Subjects
Abstract:
... Manganese (Mn) is an essential trace element. Excessive exposure to Mn may lead to neuronal death and neurodegenerative disorders. Accumulating evidence has shown that silent mating type information regulation 2 homolog 1 (SIRT1) plays a vital role in brain damage. However, whether aberrant SIRT1 levels contribute to Mn-induced neurotoxicity remains unknown. In this study, we report the important ...
DOI:
10.1016/j.scitotenv.2018.07.363

7. Guardians of the ERAD Galaxy

Author:
Sun, Zhihao; Brodsky, Jeffrey L.
Source:
Cell 2017 v.171 pp. 267-268
ISSN:
0092-8674
Subject:
protein degradation,   etc   ; endoplasmic reticulum; protein folding; proteins;     Show all 4 Subjects
Abstract:
... The endoplasmic reticulum-associated degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al. report on a protein complex that acts as a guardian to protect these folding intermediates from being targeted for ERAD. ...
DOI:
10.1016/j.cell.2017.09.023

8. Limited and digestive proteolysis: crosstalk between evolutionary conserved pathways

Author:
Minina, Elena A.; Moschou, Panagiotis N.; Bozhkov, Peter V.
Source:
The new phytologist 2017 v.215 no.3 pp. 958-964
ISSN:
0028-646X
Subject:
protein degradation,   etc   ; autophagy; polypeptides; proteinases; proteins; proteolysis;     Show all 6 Subjects
Abstract:
... Contents 958 I. 958 II. 959 III. 960 IV. 962 V. 962 962 References 963 SUMMARY: Proteases can either digest target proteins or perform the so‐called ‘limited proteolysis’ by cleaving polypeptide chains at specific site(s). Autophagy and the ubiquitin–proteasome system (UPS) are two main mechanisms carrying out digestive proteolysis. While the net outcome of digestive proteolysis is the loss of fun ...
DOI:
10.1111/nph.14627

9. Unraveling the CHIP:Hsp70 complex as an information processor for protein quality control Proteins and proteomics

Author:
VanPelt, Jamie; Page, Richard C.
Source:
Biochimica et biophysica acta 2017 v.1865 no.2 pp. 133-141
ISSN:
1570-9639
Subject:
protein degradation,   etc   ; protein conformation; proteins; ubiquitination;     Show all 4 Subjects
Abstract:
... The CHIP:Hsp70 complex stands at the crossroads of the cellular protein quality control system. Hsp70 facilitates active refolding of misfolded client proteins, while CHIP directs ubiquitination of misfolded client proteins bound to Hsp70. The direct competition between CHIP and Hsp70 for the fate of misfolded proteins leads to the question: how does the CHIP:Hsp70 complex execute triage decisions ...
DOI:
10.1016/j.bbapap.2016.11.005

10. Light-induced protein degradation in human-derived cells

Author:
Sun, Wansheng; Zhang, Wenyao; Zhang, Chao; Mao, Miaowei; Zhao, Yuzheng; Chen, Xianjun; Yang, Yi
Source:
Biochemical and biophysical research communications 2017
ISSN:
0006-291X
Subject:
protein degradation,   etc   ; Avena sativa; luciferase; oxygen;     Show all 4 Subjects
Abstract:
... Controlling protein degradation can be a valuable tool for posttranslational regulation of protein abundance to study complex biological systems. In the present study, we designed a light-switchable degron consisting of a light oxygen voltage (LOV) domain of Avena sativa phototropin 1 (AsLOV2) and a C-terminal degron. Our results showed that the light-switchable degron could be used for rapid and ...
DOI:
10.1016/j.bbrc.2017.04.041

11. Understanding the decay of proteins: A method to study time dependent response of pM concentration of insulin at microwave frequencies

Author:
Verma, Ritika; Daya, K.S.
Source:
MethodsX 2017 v.4 pp. 35-41
ISSN:
2215-0161
Subject:
protein degradation,   etc   ; bioactive properties; insulin; metabolism; proteins;     Show all 5 Subjects
Abstract:
... Bio-molecule when isolated from its natural ecological condition is subjected to rapid decay. This decay leads to change in polarization and permittivity of molecule. This study presents an experimental analysis of the decay pattern of pM concentration of insulin using whispering gallery mode (WGM) dielectric resonator (DR) method. Analysis is carried out by comparing the permittivity, relaxation ...
DOI:
10.1016/j.mex.2016.11.004

12. Pilot‐scale Protamex™‐catalysed production of round scad protein hydrolysates:effects of agitation alone and combined with aeration

Author:
Yao, Yujing; Yang, Juan; Sun‐Waterhouse, Dongxiao; Cui, Chun; Wang, Wei; Dong, Keming
Source:
International journal of food science & technology 2018 v.53 no.10 pp. 2308-2315
ISSN:
0950-5423
Subject:
protein degradation,   etc   ; aeration; agitation; anaerobes; bacteria; cadaverine; hydrolysis; nitrogen; plate count; protein hydrolysates; proteolysis; raw materials;     Show all 12 Subjects
Abstract:
... A pilot‐scale production of round scad protein hydrolysates via Protamex™‐catalysed proteolysis was firstly established. Process optimisation then focused on the use of mechanical agitation (MA) alone or combined with aeration (MAA). Comparative examinations revealed that proteolysis involving either MA or MAA was feasible with a hydrolysis degree up to 55%, and individual and total biogenic amine ...
DOI:
10.1111/ijfs.13822

13. Solution structure of the N-terminal domain of proteasome lid subunit Rpn5

Author:
Zhang, Wenbo; Zhao, Cong; Hu, Yunfei; Jin, Changwen
Source:
Biochemical and biophysical research communications 2018 v.504 no.1 pp. 225-230
ISSN:
0006-291X
Subject:
protein degradation,   etc   ; humans; nuclear magnetic resonance spectroscopy; proteasome endopeptidase complex; protein-protein interactions; yeasts;     Show all 6 Subjects
Abstract:
... The 26S proteasome is the major protein degradation machinery in living cells. The Rpn5 protein is one scaffolding subunit in the lid subcomplex of the 19S regulatory particle in the proteasome holoenzyme. Herein we report the solution structure of the N-terminal domain (NTD) of yeast Rpn5 at high resolution by NMR spectroscopy. The results show that Rpn5 NTD adopts α-solenoid-like fold in right-h ...
DOI:
10.1016/j.bbrc.2018.08.159

14. Mechanisms of Photodamage and Protein Turnover in Photoinhibition

Author:
Li, Lei; Aro, Eva-Mari; Millar, A. Harvey
Source:
Trends in plant science 2018 v.23 no.8 pp. 667-676
ISSN:
1360-1385
Subject:
protein degradation,   etc   ; NAD(P)H dehydrogenase (quinone); energy; mutation; photoinhibition; photostability; photosystem II; protein metabolism; proteins;     Show all 9 Subjects
Abstract:
... Rapid protein degradation and replacement is an important response to photodamage and a means of photoprotection by recovering proteostasis. Protein turnover and translation efficiency studies have discovered fast turnover subunits in cytochrome b6f and the NAD(P)H dehydrogenase (NDH) complex, in addition to PSII subunit D1. Mutations of these complexes have been linked to enhanced photodamage at ...
DOI:
10.1016/j.tplants.2018.05.004

15. Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome

Author:
Ramachandran, Kapil V.; Fu, Jack M.; Schaffer, Thomas B.; Na, Chan Hyun; Delannoy, Michael; Margolis, Seth S.
Source:
Molecular cell 2018 v.71 no.1 pp. 169-177.e6
ISSN:
1097-2765
Subject:
protein degradation,   etc   ; genes; homeostasis; mass spectrometry; neurons; polypeptides; proteasome endopeptidase complex; protein synthesis; proteins;     Show all 9 Subjects
Abstract:
... Activity-dependent changes in neuronal function require coordinated regulation of the protein synthesis and protein degradation machinery to maintain protein homeostasis, critical for proper neuronal function. However, the biochemical evidence for this balance and coordination is largely lacking. Leveraging our recent discovery of a neuronal-specific 20S membrane proteasome complex (NMP), we began ...
DOI:
10.1016/j.molcel.2018.06.013

16. Knowns and unknowns of plasma membrane protein degradation in plants

Author:
Liu, Chuanliang; Shen, Wenjin; Yang, Chao; Zeng, Lizhang; Gao, Caiji
Source:
Plant science 2018 v.272 pp. 55-61
ISSN:
0168-9452
Subject:
protein degradation,   etc   ; autophagy; homeostasis; membrane proteins; plant development; plasma membrane; protein metabolism; protein transport; vacuoles;     Show all 9 Subjects
Abstract:
... Plasma membrane (PM) not only creates a physical barrier to enclose the intracellular compartments but also mediates the direct communication between plants and the ever-changing environment. A tight control of PM protein homeostasis by selective degradation is thus crucial for proper plant development and plant-environment interactions. Accumulated evidences have shown that a number of plant PM p ...
DOI:
10.1016/j.plantsci.2018.04.008

17. Cellular functions of stem cell factors mediated by the ubiquitin–proteasome system

Author:
Choi, Jihye; Baek, Kwang-Hyun
Source:
Cellular and molecular life sciences 2018 v.75 no.11 pp. 1947-1957
ISSN:
1420-682X
Subject:
protein degradation,   etc   ; biomarkers; embryonic stem cells; human diseases; mitosis; prognosis; proteolysis; telomerase; therapeutics; transcription factors;     Show all 10 Subjects
Abstract:
... Stem cells undergo partitioning through mitosis and separate into specific cells of each of the three embryonic germ layers: endoderm, mesoderm, and ectoderm. Pluripotency, reprogramming, and self-renewal are essential elements of embryonic stem cells (ESCs), and it is becoming evident that regulation of protein degradation mediated by the ubiquitin–proteasome system (UPS) is one of the key cellul ...
DOI:
10.1007/s00018-018-2770-7

18. Melatonin Antagonizes Jasmonate-Triggered Anthocyanin Biosynthesis in Arabidopsis thaliana

Author:
Ai, Yu; Zhu, Ziqiang
Source:
Journal of agricultural and food chemistry 2018 v.66 no.21 pp. 5392-5400
ISSN:
1520-5118
Subject:
protein degradation,   etc   ; Arabidopsis thaliana; anthocyanins; biosynthesis; genetic markers; jasmonic acid; melatonin; metabolites; nutrition; phenotype;     Show all 10 Subjects
Abstract:
... As a plant-specific flavonoid type metabolite, anthocyanin is an important plant-sourced nutrition. Although the anthocyanin biosynthesis pathway has been revealed, how to modulate anthocyanin production by endogenous molecules is still elusive. Here, we investigated the role of melatonin in anthocyanin biosynthesis in the reference plant Arabidopsis thaliana and found that melatonin suppresses an ...
DOI:
10.1021/acs.jafc.8b01795

19. PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery

Author:
Gu, Shanshan; Cui, Danrui; Chen, Xiaoyu; Xiong, Xiufang; Zhao, Yongchao
Source:
BioEssays 2018 v.40 no.4 pp. e1700247
ISSN:
0265-9247
Subject:
protein degradation,   etc   ; drugs; ligands; therapeutics; transcription (genetics); transcription factors; ubiquitin-protein ligase;     Show all 7 Subjects
Abstract:
... Proteolysis‐targeting chimeric molecules (PROTACs) represent an emerging technique that is receiving much attention for therapeutic intervention. The mechanism is based on the inhibition of protein function by hijacking a ubiquitin E3 ligase for protein degradation. The hetero‐bifunctional PROTACs contain a ligand for recruiting an E3 ligase, a linker, and another ligand to bind with the protein t ...
DOI:
10.1002/bies.201700247

20. On the Trails of the Proteasome Fold: Structural and Functional Analysis of the Ancestral β-Subunit Protein Anbu

Author:
Vielberg, Marie-Theres; Bauer, Verena C.; Groll, Michael
Source:
Journal of molecular biology 2018 v.430 pp. 628-640
ISSN:
0022-2836
Subject:
protein degradation,   etc   ; Archaea; Bronsted acids; Hyphomicrobium; hydrogen bonding; proteasome endopeptidase complex; protein subunits; proteinases; topology;     Show all 9 Subjects
Abstract:
... The 20S proteasome is a key player in eukaryotic and archaeal protein degradation, but its progenitor in eubacteria is unknown. Recently, the ancestral β-subunit protein (Anbu) was predicted to be the evolutionary precursor of the proteasome. We crystallized Anbu from Hyphomicrobium sp. strain MC1 in four different space groups and solved the structures by SAD-phasing and Patterson search calculat ...
DOI:
10.1016/j.jmb.2018.01.004