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1. Liver vs. spleen: Time course of organ-dependent immune gene expression in an LPS-stimulated toad (Rhinella diptycha)

Author:
Felipe R. Floreste; Braz Titon; Stefanny C.M. Titon; Sandra M. Muxel; Aymam C. de Figueiredo; Fernando R. Gomes; Vania R. Assis
Source:
Comparative biochemistry and physiology 2023 v.263 pp. 110784
ISSN:
1096-4959
Subject:
protein synthesis,   etc   ; Rhinella; adults; complement; gene expression; inflammation; interleukin-10; interleukin-6; liver; males; models; spleen; toads;     Show all 13 Subjects
Abstract:
... The inflammatory response comprises highly orchestrated events that are conserved amongst vertebrate groups. Hepatic and splenic cytokines are major mediators of the systemic inflammatory processes. However, the liver is still neglected as an immune organ in amphibians. This study reports organ-dependent gene expression using an anuran model. We tracked mRNA levels of immune proteins [C1s (subcomp ...
DOI:
10.1016/j.cbpb.2022.110784

2. Isolation and functional identification of secretin family G-protein coupled receptor from Y-organ of the mud crab, Scylla olivacea

Author:
Sirinart Techa; Wilawan Thongda; Phimsucha Bunphimpapha; Wanwipa Ittarat; Manon Boonbangyang; Alisa Wilantho; Chumpol Ngamphiw; Boonyarath Pratoomchat; Prachumporn Nounurai; Sanit Piyapattanakorn
Source:
Gene 2023 v.848 pp. 146900
ISSN:
0378-1119
Subject:
protein synthesis,   etc   ; G-protein coupled receptors; Scylla olivacea; cholesterol; crabs; cytosol; disulfides; ecdysone; genes; hindgut; lipoprotein receptors; secretin; thoracic ganglia;     Show all 13 Subjects
Abstract:
... Recently, genes in the superfamily of GPCR are gaining more interest in crustaceans as more evidence shows that they are involved in molting. This study identified four forms of the secretin family of G-protein coupled receptor (GPCR) from the Y-organ of mud crab, Scylla olivacea (ScoGPCR). A full-length sequence of ScoGPCR-B2 was isolated and identified as a lipoprotein receptor while three forms ...
DOI:
10.1016/j.gene.2022.146900

3. Effect and mechanism of functional compound fruit drink on gut microbiota in constipation mice

Author:
Yali Shi; Fei Chen; Ziqi Wang; Jun Cao; Chuan Li
Source:
Food chemistry 2023 v.401 pp. 134210
ISSN:
0308-8146
Subject:
protein synthesis,   etc   ; active ingredients; blood serum; constipation; food chemistry; fructooligosaccharides; fruit drinks; fruits; gastrointestinal motility; gastrointestinal system; gene expression; intestinal microorganisms; mice; models; peptides; prebiotics; species richness;     Show all 17 Subjects
Abstract:
... Compound fruit drink (CFD) is a functional drink prepared with fruit, Chinese herbs and prebiotic fructooligosaccharide as the main ingredients. Loperamide hydrochloride was used to establish a mouse model of constipation. And the effect of CFD on the improvement of constipation and the impact on gut microbiota were studied. The results showed that CFD significantly enhanced intestinal motility in ...
DOI:
10.1016/j.foodchem.2022.134210

4. The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways

Author:
Chunxing Pan; Xiaoying Liu; Yating Zheng; Zejun Zhang; Yongliang Li; Biao Che; Guangrong Liu; Lanyue Zhang; Changzhi Dong; Haji Akber Aisa; Zhiyun Du; Zhengqiang Yuan
Source:
Food science and human wellness 2023 v.12 no.1 pp. 212-222
ISSN:
2213-4530
Subject:
protein synthesis,   etc   ; food science; health services; hormone receptors; humans; hydrophobicity; hyperpigmentation; inflammation; ingredients; licorice; melanocytes; melanogenesis; melanoma; mice; models; roughness; therapeutics; transcription (genetics); transcription factors; ultraviolet radiation;     Show all 20 Subjects
Abstract:
... Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins. However, the underlying mechanism(s) remain not completely understood. The aim of this study is thus to elucidate the possible mechanisms related to the melanogenesis suppression by glabridin in cultured B16 murine melanoma cells and in UVA radiation induced ...
DOI:
10.1016/j.fshw.2022.07.011

5. Interaction of Polycyclic Aromatic Hydrocarbon compounds in fish primary hepatocytes: From molecular mechanisms to genotoxic effects

Author:
Isabella Bramatti; Beatriz Matos; Neusa Figueiredo; Pedro Pousão-Ferreira; Vasco Branco; Marta Martins
Source:
Science of the total environment 2023 v.855 pp. 158783
ISSN:
0048-9697
Subject:
protein synthesis,   etc   ; DNA; DNA damage; Sparus aurata; Western blotting; carcinogenicity; cell viability; chemical structure; comet assay; environment; environmental assessment; fish; genes; genotoxicity; hepatocytes; metabolites; mutagens; phenanthrenes; risk assessment;     Show all 19 Subjects
Abstract:
... Polycyclic Aromatic Hydrocarbons (PAHs) are persistent pollutants normally found in the environment as complex mixtures. Although several individual PAHs are classified as mutagenic and carcinogenic pollutants, the interaction effects between compounds in a mixture may trigger different toxicological mechanisms and, consequently, yield different effects to organisms which are not accounted for in ...
DOI:
10.1016/j.scitotenv.2022.158783

6. Structural, functional, and physicochemical characterization of fermented whey protein concentrates recovered from various fermented-distilled whey

Author:
Munkh-Amgalan Gantumur; Narantuya Sukhbaatar; Ruijie Shi; Jialun Hu; Akhunzada Bilawal; Abdul Qayum; Bo Tian; Zhanmei Jiang; Juncai Hou
Source:
Food hydrocolloids 2023 v.135 pp. 108130
ISSN:
0268-005X
Subject:
protein synthesis,   etc   ; alcoholic fermentation; amino acids; cheesemaking; cost effectiveness; gel chromatography; hydrocolloids; hydrophobicity; milk; particle size; polyacrylamide gel electrophoresis; solubility; value added; whey; whey protein concentrate; zeta potential;     Show all 16 Subjects
Abstract:
... The utilization of whey has become a challenge with the significant growth in the production of cheese and coagulated milk products. Consequently, we have developed cost-effective and waste-free production technologies for processing whey disposal into a variety of high-quality, value-added food products at the industrial level. This work constitutes a research on the impact of various alcoholic f ...
DOI:
10.1016/j.foodhyd.2022.108130

7. Phenolics from noni (Morinda citrifolia L.) fruit alleviate obesity in high fat diet-fed mice via modulating the gut microbiota and mitigating intestinal damage

Author:
Ruimin Wang; Lu Wang; Shengwei Wang; Juntao Wang; Congyan Su; Lin Zhang; Congfa Li; Sixin Liu
Source:
Food chemistry 2023 v.402 pp. 134232
ISSN:
0308-8146
Subject:
protein synthesis,   etc   ; Morinda citrifolia; anti-obesity effects; dysbiosis; food chemistry; fruits; high fat diet; inflammation; intestinal microorganisms; intestines; lipopolysaccharides; liver; obesity; occludins; oxidative stress; phenolic compounds; short chain fatty acids;     Show all 17 Subjects
Abstract:
... Noni fruit has certain anti-obesity effect. However, the bioactive ingredients in noni fruit that contribute to anti-obesity activity as well as the relation between its anti-obesity activity and gut microbiota remain unclear. In this study, obese mice induced by high-fat diet (HFD) and were intervened with noni fruit phenolic extract (NFE) for 10 weeks. The results showed NFE supplementation decr ...
DOI:
10.1016/j.foodchem.2022.134232

8. Effects of different fatty acid ligands on the host-guest interaction of astaxanthin-bovine serum albumin: Thermodynamical analysis, binding site identification, and in vivo antioxidant evaluation

Author:
Donghui Li; Yunjun Liu; Yixiang Liu; Shengnan Wang; Zixin Guo; Jie Li; Yanbo Wang
Source:
Food hydrocolloids 2023 v.134 pp. 108112
ISSN:
0268-005X
Subject:
protein synthesis,   etc   ; antioxidant activity; antioxidants; arachidonic acid; astaxanthin; bovine serum albumin; docosahexaenoic acid; dodecanoic acid; hydrocolloids; hydrogen; hydrophilicity; ligands; linoleic acid; oleic acid; palmitic acid; stearic acid; thermodynamics; van der Waals forces;     Show all 18 Subjects
Abstract:
... The multi-ligand binding properties of proteins make the introduction of small-molecule ligands an effective approach through which to improve the biological functions of protein-based carriers. In this study, the effect of fatty acids (FAs) as functional ligands on the self-assembly of astaxanthin (ASTA) and bovine serum albumin (BSA) and the in vivo antioxidant properties of their ternary ligand ...
DOI:
10.1016/j.foodhyd.2022.108112

9. DBDPE and ZnO NPs synergistically induce neurotoxicity of SK-N-SH cells and activate mitochondrial apoptosis signaling pathway and Nrf2-mediated antioxidant pathway

Author:
Liying Dong; Shutao Wang; Lin Zhang; Dongmei Liu; Hong You
Source:
Journal of hazardous materials 2023 v.441 pp. 129872
ISSN:
0304-3894
Subject:
protein synthesis,   etc   ; antioxidant enzymes; apoptosis; bioinformatics; caspase-3; cytochrome c; cytotoxicity; decabromodiphenyl ethane; flame retardants; gene expression; homeostasis; humans; membrane potential; mitochondria; mitochondrial membrane; nanoparticles; neurotoxicity; oxidative stress; risk perception; viability; zinc oxide;     Show all 21 Subjects
Abstract:
... Decabromodiphenyl ethane (DBDPE), a new brominated flame retardant, could negatively affect neurobehavior and pose health risks to humans. Humans are also exposed to widely used nanomaterials. This study investigated the combined toxic effects and action types of DBDPE and Zinc oxide nanoparticles (ZnO NPs) on human neuroblastoma SK-N-SH cells and the toxicity mechanisms. DBDPE inhibited the viabi ...
DOI:
10.1016/j.jhazmat.2022.129872

10. Ambient NO2 exposure affects hepatic glycolipid metabolism in mice with a sex-dependent property

Author:
Yuqiong Guo; Shaoyang Ji; Dan Li; Nan Sang
Source:
Journal of hazardous materials 2023 v.441 pp. 129957
ISSN:
0304-3894
Subject:
protein synthesis,   etc   ; absorption; air; blood glucose; blood serum; breathing; cardiovascular diseases; diabetes; fatty acids; fatty liver; females; galactose; gluconeogenesis; glucose; glucose tolerance; glycerophospholipids; glycogen; glycolipids; inhalation exposure; lipid peroxidation; lipogenesis; liver; males; metabolites; metabolomics; risk; secretion;     Show all 27 Subjects
Abstract:
... NO₂ is one of the major air pollutants. Exposure to NO₂ is associated with various metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD), diabetes, cardiovascular disease, etc. Abnormal hepatic glycolipid metabolism is a key feature of metabolic diseases. However, few studies provide evidence for the effects of NO₂ inhalation on hepatic glycolipid metabolism. In this study, female ...
DOI:
10.1016/j.jhazmat.2022.129957

11. Dietary fiber konjac glucomannan exerts an antidiabetic effect via inhibiting lipid absorption and regulation of PPAR-γ and gut microbiome

Author:
Muthukumaran Jayachandran; Sunil Christudas; Xuchu Zheng; Baojun Xu
Source:
Food chemistry 2023 v.403 pp. 134336
ISSN:
0308-8146
Subject:
protein synthesis,   etc   ; absorption; blood lipids; body weight; dietary fiber; drugs; fibrosis; food chemistry; glycemic effect; high fat diet; hyperlipidemia; immunohistochemistry; insulin; intestinal microorganisms; konjac mannan; lipid composition; lipid metabolism; lipids; liver; microbiome; noninsulin-dependent diabetes mellitus; streptozotocin;     Show all 22 Subjects
Abstract:
... Konjac glucomannan’s influence on the regulation of diabetes mellitus, hyperlipidemia, and gut microbial flora was evaluated in this study. In addition, a high-fat diet and streptozotocin were used to induce type 2 diabetes mellitus in rats. At the end of the study, we analyzed various parameters such as body weight, plasma lipid profile, insulin levels by immunohistochemistry, degree of fibrosis ...
DOI:
10.1016/j.foodchem.2022.134336

12. An integrated proteomics and metabolomics investigation of feed efficiency in seawater reared Chinook salmon (Oncorhynchus tshawytscha)

Author:
Moha Esmaeili; Chris G. Carter; Richard Wilson; Seumas P. Walker; Matthew R. Miller; Andrew R. Bridle; Tim Young; Andrea C. Alfaro; Olivier Laroche; Jane E. Symonds
Source:
Aquaculture 2023 v.562 pp. 738845
ISSN:
0044-8486
Subject:
protein synthesis,   etc   ; Oncorhynchus tshawytscha; amino acid metabolism; aquaculture; blood plasma; catabolism; data collection; feed conversion; fish; genes; glucose; glutathione; isoleucine; leucine; liver; metabolites; metabolomics; multiomics; muscles; phenotype; phenylalanine; protein degradation; proteolysis; proteomics; pyruvic acid; seawater; tryptophan; tyrosine; valine;     Show all 29 Subjects
Abstract:
... Feed efficiency (FE) is a critical phenotype for aquaculture sustainability, yet it is poorly understood at the molecular level. In this study, the molecular basis of FE was investigated using a multi-omics approach to integrate proteome-level data and metabolites associated with differences in feed efficiency. To achieve this, Chinook salmon (Oncorhynchus tshawytscha) were reared in seawater and ...
DOI:
10.1016/j.aquaculture.2022.738845

13. A novel milk-derived peptide effectively inhibits Staphylococcus aureus: Interferes with cell wall synthesis, peptidoglycan biosynthesis disruption reaction mechanism, and its application in real milk system

Author:
Yanan Shi; Yufang Li; Kun Yang; Guangqiang Wei; Aixiang Huang
Source:
Food control 2023 v.144 pp. 109374
ISSN:
0956-7135
Subject:
protein synthesis,   etc   ; DNA repair; Staphylococcus aureus; anti-infective agents; antimicrobial peptides; antimicrobial properties; biosynthesis; buffalo milk; cell walls; food preservation; food safety; gene expression regulation; glutamic acid; glutamine; metabolites; milk; peptidoglycans; proteome; proteomics; quantitative polymerase chain reaction; reaction mechanisms; ultrastructure;     Show all 22 Subjects
Abstract:
... BCp12, a novel antimicrobial agent derived from buffalo milk, poses superior antimicrobial activity against Staphylococcus aureus. In the present study, the effect of BCp12 on the cell wall synthesis and molecular pathways of Staphylococcus aureus was studied by the CLSM, SEM and proteomics analyses to facilitate the development of this novel antimicrobial peptide. The results demonstrated that BC ...
DOI:
10.1016/j.foodcont.2022.109374

14. Integrated multiple-omics reveals the regulatory mechanism underlying the effects of artificial feed and grass feeding on growth and muscle quality of grass carp (Ctenopharyngodon idellus)

Author:
Honghao Zhao; Jasmine Chong; Dapeng Li; Jianguo Xia
Source:
Aquaculture 2023 v.562 pp. 738808
ISSN:
0044-8486
Subject:
protein synthesis,   etc   ; Ctenopharyngodon idella; aquaculture; beta oxidation; cell proliferation; droplets; farmed fish; flavor; glycogen; glycolysis; grasses; hypertrophy; insulin resistance; lipids; muscle fibers; muscles; necroptosis; peroxisome proliferator-activated receptor alpha; phosphatidylinositol 3-kinase; proteolysis; proteomics; stress tolerance; texture; transcriptomics; tricarboxylic acid cycle; ubiquitin;     Show all 26 Subjects
Abstract:
... The muscle quality of farmed fish has attracted widespread public attention. To understand a comprehensive molecular mechanism underlying the effects of artificial formula feed- (AF) and grass-feeding (GF) on muscle quality and growth of grass carp (Ctenopharyngodon idellus), muscular transcriptomics and proteomics of GF and AF C. idellus were characterized. A total of 834 DEGs (484 up-, 350 down- ...
DOI:
10.1016/j.aquaculture.2022.738808

15. ATACing single cells with phages

Author:
Patrick Maschmeyer; Simon Haas
Source:
Molecular cell 2022 v.82 no.2 pp. 234-236
ISSN:
1097-2765
Subject:
protein synthesis,   etc   ; chromatin; mitochondrial DNA;     Show all 3 Subjects
Abstract:
... Fiskin et al. (2021) developed a “multi-omics” approach that integrates phage-displayed single-domain antibodies (“nanobodies”) with the assay for transposase-accessible chromatin (PHAGE-ATAC) to simultaneously determine protein expression, chromatin accessibility, and mitochondrial DNA mutations (for clonal tracing) in single cells. ...
DOI:
10.1016/j.molcel.2021.12.028

16. RNA-Binding Proteins as Regulators of Internal Initiation of Viral mRNA Translation

Author:
Brenda López-Ulloa; Yazmín Fuentes; Magdalena S. Pizarro-Ortega; Marcelo López-Lastra
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
protein synthesis,   etc   ; gene expression; ribosomes;     Show all 3 Subjects
Abstract:
... Viruses are obligate intracellular parasites that depend on the host’s protein synthesis machinery for translating their mRNAs. The viral mRNA (vRNA) competes with the host mRNA to recruit the translational machinery, including ribosomes, tRNAs, and the limited eukaryotic translation initiation factor (eIFs) pool. Many viruses utilize non-canonical strategies such as targeting host eIFs and RNA el ...
DOI:
10.3390/v14020188

17. Dynamical network biomarkers: Theory and applications

Author:
Kazuyuki Aihara; Rui Liu; Keiichi Koizumi; Xiaoping Liu; Luonan Chen
Source:
Gene 2022 v.808 pp. 145997
ISSN:
0378-1119
Subject:
protein synthesis,   etc   ; biomarkers; genes; traditional medicine;     Show all 4 Subjects
Abstract:
... This paper reviews theory of DNB (Dynamical Network Biomarkers) and its applications including both modern medicine and traditional medicine. We show that omics data such as gene/protein expression profiles can be effectively used to detect pre-disease states before critical transitions from healthy states to disease states by using the DNB theory. The DNB theory with big biological data is expect ...
DOI:
10.1016/j.gene.2021.145997

18. The Fragile X Proteins Differentially Regulate Translation of Reporter mRNAs with G-quadruplex Structures

Author:
Madison Edwards; Simpson Joseph
Source:
Journal of molecular biology 2022 v.434 no.2 pp. 167396
ISSN:
0022-2836
Subject:
protein synthesis,   etc   ; autism; cyclins; molecular biology;     Show all 4 Subjects
Abstract:
... Fragile X Syndrome, as well as some manifestations of autism spectrum disorder, results from improper RNA regulation due to a deficiency of fragile X mental retardation protein (FMRP). FMRP and its autosomal paralogs, fragile X related proteins 1 & 2 (FXR1P/2P), have been implicated in many aspects of RNA regulation, from protein synthesis to mRNA stability and decay. The literature on the fragile ...
DOI:
10.1016/j.jmb.2021.167396

19. SnapShot: Skeletal muscle atrophy

Author:
Leslie M. Baehr; David C. Hughes; David S. Waddell; Sue C. Bodine
Source:
Cell 2022 v.185 no.9 pp. 1618
ISSN:
0092-8674
Subject:
protein synthesis,   etc   ; muscular atrophy; skeletal muscle;     Show all 3 Subjects
Abstract:
... Skeletal muscle size is highly plastic and sensitive to a variety of stimuli. Muscle atrophy occurs as the result of changes in multiple signaling pathways that regulate both protein synthesis and degradation. The signaling pathways that are activated or inhibited depend on the specific stimuli that are altered. To view this SnapShot, open of download the PDF. ...
DOI:
10.1016/j.cell.2022.03.028

20. A co-expression vector for baculovirus-mediated protein expression in mammalian cells

Author:
Wenjun Guo; Mengmeng Wang; Lei Chen
Source:
Biochemical and biophysical research communications 2022 v.594 pp. 69-73
ISSN:
0006-291X
Subject:
protein synthesis,   etc   ; humans; insects; research; toxicity; viruses;     Show all 6 Subjects
Abstract:
... BacMam system utilizes baculovirus to deliver exogenous genes into mammalian cells and is extensively used for recombinant production of eukaryotic proteins. Here, we described the development of a BacMam vector (pBMCL1), which allows convenient tracing of virus production, provides higher infection efficiency towards mammalian cells, minimizes unwanted transcription of toxic genes in insect cells ...
DOI:
10.1016/j.bbrc.2022.01.056