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1. Vesicles Spread Susceptibility to Phages

Author:
Ofir, Gal; Sorek, Rotem
Source:
Cell 2017 v.168 pp. 13-15
ISSN:
0092-8674
Subject:
virus receptors,   etc   ; bacteria; bacteriophages;     Show all 3 Subjects
Abstract:
... Extracellular membrane vesicles from bacteria are now shown to transfer phage receptors from susceptible to resistant cells, thus making them transiently sensitive to phage infection (Tzipilevich et al.). ...
DOI:
10.1016/j.cell.2016.12.035

2. Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes

Author:
Macri, Christophe; Dumont, Claire; Panozza, Scott; Lahoud, Mireille H.; Caminschi, Irina; Villadangos, Jose A.; Johnston, Angus P.R.; Mintern, Justine D.
Source:
Molecular Immunology 2017 v.81 pp. 143-150
ISSN:
0161-5890
Subject:
receptors,   etc   ; antigens; mice; vaccination;     Show all 4 Subjects
Abstract:
... Targeting antigen (Ag) to dendritic cell (DC) surface receptors is a potential new mode of vaccination. C-type lectin-like receptors Clec9A and Clec12A are attractive receptor targets however their targeting in vivo elicits significantly different outcomes for unknown reasons. To gain insight into the mechanisms responsible, we have examined the intrinsic capacity of Clec9A and Clec12A to elicit M ...
DOI:
10.1016/j.molimm.2016.12.010

3. Advances in the role of oxytocin receptors in human parturition

Author:
Kim, Sung Hye; Bennett, Phillip R.; Terzidou, Vasso
Source:
Molecular and Cellular Endocrinology 2017
ISSN:
0303-7207
Subject:
G-protein coupled receptors; oxytocin receptors,   etc   ; inflammation; microRNA; oxytocin; parturition;     Show all 6 Subjects
Abstract:
... Oxytocin (OT) is a neurohypophysial hormone which has been found to play a central role in the regulation of human parturition. The most established role of oxytocin/oxytocin receptor (OT/OTR) system in human parturition is the initiation of uterine contractions, however, recent evidence have demonstrated that it may have a more complex role including initiation of inflammation, regulation of miRN ...
DOI:
10.1016/j.mce.2017.01.034

4. Membrane-induced organization and dynamics of the N-terminal domain of chemokine receptor CXCR1: insights from atomistic simulations

Author:
Kharche, Shalmali; Joshi, Manali; Sengupta, Durba; Chattopadhyay, Amitabha
Source:
Chemistry and physics of lipids 2017
ISSN:
0009-3084
Subject:
CXCR1 receptor,   etc   ; cell membranes; ligands;     Show all 3 Subjects
Abstract:
... The CXC chemokine receptor 1 (CXCR1) is an important member of the G protein-coupled receptor (GPCR) family in which the extracellular N-terminal domain has been implicated in ligand binding and selectivity. The structure of this domain has not yet been elucidated due to its inherent dynamics, but experimental evidence points toward membrane-dependent organization and dynamics. To gain molecular i ...
DOI:
10.1016/j.chemphyslip.2017.09.003

5. Synergistic effect of co-stimulation of membrane and endosomal TLRs on chicken innate immune responses

Author:
Kim, Sungwon; Kaiser, Pete; Borowska, Dominika; Vervelde, Lonneke
Source:
Veterinary immunology and immunopathology 2018 v.199 pp. 7-21
ISSN:
0165-2427
Subject:
Toll-like receptor 2; Toll-like receptor 4; Toll-like receptor 7,   etc   ; cell death; cell proliferation; chickens; genes; innate immunity; interleukin-10; interleukin-12; interleukin-1beta; ligands; lipid A; macrophages; mammals; messenger RNA; nitric oxide; splenocytes; synergism; vaccine adjuvants;     Show all 20 Subjects
Abstract:
... Toll-like receptor (TLR) ligands (TLR-Ls) are critical activators of immunity and are successfully being developed as vaccine adjuvants in both mammals and birds. In this study, we investigated the synergistic effect of co-stimulation of membrane and endosomal TLRs on the innate immune responses using chicken bone marrow-derived macrophages (BMMs), and studied the effect of age on the induction of ...
DOI:
10.1016/j.vetimm.2018.03.005

6. Toll-like receptor expression and apoptosis morphological patterns in female rat hearts with takotsubo syndrome induced by isoprenaline

Author:
Kołodzińska, Agnieszka; Czarzasta, Katarzyna; Szczepankiewicz, Benedykt; Główczyńska, Renata; Fojt, Anna; Ilczuk, Tomasz; Budnik, Monika; Krasuski, Krzysztof; Folta, Miłosz; Cudnoch-Jędrzejewska, Agnieszka; Górnicka, Barbara; Opolski, Grzegorz
Source:
Life sciences 2018 v.199 pp. 10-121
ISSN:
0024-3205
Subject:
Toll-like receptor 2; Toll-like receptor 4; Toll-like receptor 6,   etc   ; apoptosis; cardiomyocytes; endothelial cells; females; heart failure; innate immunity; isoprenaline; macrophages; messenger RNA; models; pathophysiology; protein synthesis; rats; sodium chloride;     Show all 17 Subjects
Abstract:
... Toll-like receptors (TLR) and apoptosis were indicated as important factors in heart failure. Our aim was to characterize the morphological pattern of apoptosis, TLR2, TLR4, and TLR6 expression in female rat hearts in the model of takotsubo syndrome (TTS).60 Sprague-Dawley female rats were treated with a single dose of 150 mg/kg b.wt. of isoprenaline (ISO) or 0.9% NaCl (controls). Hearts were coll ...
DOI:
10.1016/j.lfs.2018.02.042

7. Expression of receptor tyrosine kinase targets PDGFR‐β, VEGFR2 and KIT in canine transitional cell carcinoma

Author:
Walters, L.; Martin, O.; Price, J.; Sula, M. M.
Source:
Veterinary and comparative oncology 2018 v.16 no.1 pp. E117-E122
ISSN:
1476-5810
Subject:
platelet-derived growth factor receptor beta; vascular endothelial growth factor receptor-2,   etc   ; bladder; cell growth; cystitis; dogs; metastasis; neoplasms; phosphates; staining; stem cell factor;     Show all 11 Subjects
Abstract:
... Transitional cell carcinoma (TCC) is the most common neoplasia of the canine urinary tract. It tends to be locally invasive and has a moderate metastatic rate. Receptor tyrosine kinases (RTKs) play an important role in promoting cell growth, differentiation and regulation of cell function. RTK inhibitor toceranib phosphate has been used anecdotally to treat TCC. The goal of this study was to evalu ...
DOI:
10.1111/vco.12344

8. Vitamin D receptor expression in canine mammary gland and relationship with clinicopathological parameters and progesterone/oestrogen receptors

Author:
Sánchez‐Céspedes, R.; Fernández‐Martínez, M. D.; Raya, A.; Pineda, C.; López, I.; Millán, Y.
Source:
Veterinary and comparative oncology 2018 v.16 no.1 pp. E185-E193
ISSN:
1476-5810
Subject:
calcitriol receptors; estrogen receptors,   etc   ; angiogenesis; animal tissues; apoptosis; breast neoplasms; calcitriol; dogs; epithelial cells; females; humans; immunohistochemistry; ligands; mammary glands; mammary neoplasms (animal); metastasis; models; progesterone; staining; therapeutics;     Show all 20 Subjects
Abstract:
... The vitamin D receptor (VDR) belongs to the nuclear class II receptor family. VDR is a ligand transcription factor and mediates the actions of calcitriol, the active product of vitamin D synthesis. Nowadays, it is known that the biological actions of calcitriol include the capacity to modulate cancer features, such as proliferation and differentiation, apoptosis, angiogenesis, invasion and metasta ...
DOI:
10.1111/vco.12371

9. Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities

Author:
Belfiore, Lisa; Saunders, Darren N.; Ranson, Marie; Thurecht, Kristofer J.; Storm, Gert; Vine, Kara L.
Source:
Journal of controlled release 2018 v.277 pp. 13-13
ISSN:
0168-3659
Subject:
receptors,   etc   ; antineoplastic activity; drug carriers; drug formulations; drugs; ligands; models; neoplasm cells; neoplasms; stromal cells; toxicity;     Show all 11 Subjects
Abstract:
... The development of therapeutic resistance to targeted anticancer therapies remains a significant clinical problem, with intratumoral heterogeneity playing a key role. In this context, improving the therapeutic outcome through simultaneous targeting of multiple tumor cell subtypes within a heterogeneous tumor is a promising approach. Liposomes have emerged as useful drug carriers that can reduce sy ...
DOI:
10.1016/j.jconrel.2018.02.040

10. Changes in expression of P2X7 receptors in rat myometrium at different gestational stages and the mechanism of ATP-induced uterine contraction

Author:
Alotaibi, Mohammed
Source:
Life sciences 2018 v.199 pp. 7-157
ISSN:
0024-3205
Subject:
receptors,   etc   ; adenosine triphosphate; calcium; enzyme-linked immunosorbent assay; myometrium; pregnancy; rats; uterine contraction;     Show all 8 Subjects
Abstract:
... Given the importance of ATP in the control of uterine activity for successful labor and involution, this study was performed to measure the level of P2X7 receptors (P2X7Rs) in rat myometrium at different gestational stages and to investigate the mechanisms of ATP-induced uterine contraction.Myometrial tissues were obtained from rats at different gestational stages and the level of P2X7Rs was measu ...
DOI:
10.1016/j.lfs.2018.03.016

11. Axl inhibitors as novel cancer therapeutic agents

Author:
Shen, Yingying; Chen, Xiguang; He, Jun; Liao, Duanfang; Zu, Xuyu
Source:
Life sciences 2018 v.198 pp. 13-111
ISSN:
0024-3205
Subject:
receptor protein-tyrosine kinase,   etc   ; breasts; cell proliferation; drug therapy; drugs; humans; lungs; metastasis; pancreatic neoplasms; patients;     Show all 10 Subjects
Abstract:
... Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain d ...
DOI:
10.1016/j.lfs.2018.02.033

12. Reasons to Be Nervous about Flukicide Discovery

Author:
McVeigh, Paul; McCusker, Paul; Robb, Emily; Wells, Duncan; Gardiner, Erica; Mousley, Angela; Marks, Nikki J.; Maule, Aaron G.
Source:
Trends in parasitology 2018 v.34 pp. 13-196
ISSN:
1471-4922
Subject:
G-protein coupled receptors,   etc   ; Fasciola hepatica; Nematoda; anthelmintics; drugs; immunocytochemistry; liver flukes; neuropeptides; neurophysiology;     Show all 9 Subjects
Abstract:
... The majority of anthelmintics dysregulate neuromuscular function, a fact most prominent for drugs against nematode parasites. In contrast to the strong knowledge base for nematode neurobiology, resource and tool deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, immunocytochemistry, and neuropeptide biochemistry 20–30 years ago. However, recent develop ...
DOI:
10.1016/j.pt.2017.11.010

13. Correction to: Cell type-specific localization of Ephs pairing with ephrin-B2 in the rat postnatal pituitary gland

Author:
Yoshida, Saishu; Kato, Takako; Kanno, Naoko; Nishimura, Naoto; Nishihara, Hiroto; Horiguchi, Kotaro; Kato, Yukio
Source:
Cell and tissue research 2018 v.371 no.2 pp. 3-387
ISSN:
0302-766X
Subject:
receptor protein-tyrosine kinase,   etc   ; cell fusion; neonatal development; pituitary gland; rats;     Show all 5 Subjects
Abstract:
... The published online version contains mistakes in Table 1, Table 2 and Fig. 2. See below for the corrected Tables and Figure. ...
DOI:
10.1007/s00441-017-2721-x

14. Numerical analysis of lightning attachment to wind turbine blade

Author:
Zhou, Qibin; Liu, Canxiang; Bian, Xiaoyan; Lo, Kwok L.; Li, Dongdong
Source:
Renewable energy 2018 v.116 pp. 584-593
ISSN:
0960-1481
Subject:
receptors,   etc   ; blades; finite element analysis; lightning; renewable energy sources; wind turbines;     Show all 6 Subjects
Abstract:
... In order to study lightning attachment characteristic of wind turbine blades, a method is proposed in this paper by using electrostatic simulation to analyze the development mechanism of the line lightning leader to establish the lightning initial attachment zones. A full-size turbine blade and a downward leader is modelled to investigate the lightning attachment characteristic by using 3D electro ...
DOI:
10.1016/j.renene.2017.09.086

15. Early pregnancy-related changes in toll-like receptors expression in ovine trophoblasts and peripheral blood leukocytes

Author:
Kaya, Mehmet Salih; Kose, Mehmet; Guzeloglu, Aydin; Kıyma, Zekeriya; Atli, Mehmet Osman
Source:
Theriogenology 2017 v.93 pp. 40-45
ISSN:
0093-691X
Subject:
Toll-like receptor 1; Toll-like receptor 10; Toll-like receptor 2,   etc   ; Toll-like receptor 3; Toll-like receptor 4; Toll-like receptor 5; Toll-like receptor 6; Toll-like receptor 7; Toll-like receptor 8; Toll-like receptor 9; complementary DNA; computer software; ewes; in situ hybridization; leukocytes; messenger RNA; pregnancy; quantitative polymerase chain reaction; statistical analysis; transcription (genetics);     Show all 20 Subjects
Abstract:
... In the present study, we aimed to 1) demonstrate the presence of all 10 toll-like receptors (TLRs) in ovine trophoblasts, and 2) investigate the expression profiles of TLR1–10 mRNAs in peripheral blood leukocytes (PBLs) in ewes during early pregnancy. For those purposes, ovine trophoblasts (n = 6) were collected from pregnant ewes on day 13. PBLs were collected from non-pregnant (n = 6) and pregna ...
DOI:
10.1016/j.theriogenology.2017.01.031

16. Hydroxylated 2-Ethylhexyl tetrabromobenzoate isomers in house dust and their agonistic activities with several nuclear receptors

Author:
Peng, Hui; Sun, Jianxian; Saunders, David M.V.; Codling, Garry; Wiseman, Steve; Jones, Paul D.; Giesy, John P.
Source:
Environmental pollution 2017
ISSN:
0269-7491
Subject:
androgen receptors; estrogen receptors; peroxisome proliferator-activated receptors,   etc   ; agonists; atmospheric pressure; derivatization; dust; geometry; humans; ionization; isomers; risk; Saskatchewan;     Show all 13 Subjects
Abstract:
... In the current study, by combining ultra-high resolution (UHR) MS1 spectra, MS2 spectra, and derivatization, three hydroxylated isomers of 2-ethylhexyl tetrabromobenzoate (OH-TBB) were identified in Firemaster® 550 and BZ-54 technical products. Also, a new LC-UHRMS method, using atmospheric pressure chemical ionization (APCI), was developed for simultaneous analysis of OH-TBB, TBB, hydroxylated bi ...
DOI:
10.1016/j.envpol.2017.04.094

17. A conceptualisation framework for building consensus on environmental sensitivity

Author:
González Del Campo, Ainhoa
Source:
Journal of environmental management 2017 v.200 pp. 114-122
ISSN:
0301-4797
Subject:
receptors,   etc   ; biodiversity; cultural heritage; risk; soil; stakeholders;     Show all 6 Subjects
Abstract:
... Examination of the intrinsic attributes of a system that render it more or less sensitive to potential stressors provides further insight into the baseline environment. In impact assessment, sensitivity of environmental receptors can be conceptualised on the basis of their: a) quality status according to statutory indicators and associated thresholds or targets; b) statutory protection; or c) inhe ...
DOI:
10.1016/j.jenvman.2017.05.061

18. Effects of unintentional PCBs in pigments and chemical products on transcriptional activity via aryl hydrocarbon and nuclear hormone receptors

Author:
Takeuchi, Shinji; Anezaki, Katsunori; Kojima, Hiroyuki
Source:
Environmental pollution 2017 v.227 pp. 306-313
ISSN:
0269-7491
Subject:
androgen receptors; estrogen receptors; glucocorticoid receptors,   etc   ; agonists; air; antagonists; chlorides; dust; pigments; polychlorinated biphenyls; reporter genes; thyroid hormone receptors; transcription (genetics);     Show all 13 Subjects
Abstract:
... In recent years, some pigments and chemical products have been reported to contain polychlorinated biphenyl (PCB) congeners as unintentional byproducts, and these have also been detected in residential environments from indoor air and house dust. In this study, using in vitro reporter gene assays, we characterized the agonistic and antagonistic activities of a total of 25 PCB congeners contained i ...
DOI:
10.1016/j.envpol.2017.04.059

19. Impact of G protein-coupled receptor heteromers in endocrine systems

Author:
Jonas, K.C.; Hanyaloglu, A.C.
Source:
Molecular and Cellular Endocrinology 2017 v.449 pp. 21-27
ISSN:
0303-7207
Subject:
G-protein coupled receptors,   etc   ; functional diversity; homeostasis;     Show all 3 Subjects
Abstract:
... The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated processes. The superfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrine axes, thus understanding the mechanisms underpinning their functionality is paramount for treatment of endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as ...
DOI:
10.1016/j.mce.2017.01.030

20. Bioactivity-guided synthesis of gramine derivatives as new MT1 and 5-HT1A receptors agonists

Author:
Yin, Xiu-Juan; Huang, Xiao-Yan; Ma, Yun-Bao; Geng, Chang-An; Li, Tian-Ze; Chen, Xing-Long; Yang, Tong-Hua; Zhou, Jun; Zhang, Xue-Mei; Chen, Ji-Jun
Source:
Journal of Asian natural products research 2017 v.19 no.6 pp. 610-622
ISSN:
1477-2213
Subject:
receptors,   etc   ; agonists; gramine; serotonin; structure-activity relationships;     Show all 5 Subjects
Abstract:
... Twenty-four gramine derivatives were synthesized and evaluated on MT ₁ and 5-HT ₁A receptors in vitro . Among them, seven derivatives (7 , 8 , 16 , 19 , 20 , 21, and 24) exhibited higher agonisting activities on MT ₁ or 5-HT ₁A receptors. Compared with gramine, derivatives 7 , 8 , 16 , 19 , 20 , 21, and 24 displayed 1.6–3.5-fold increase in agonistic rates on 5-HT ₁A receptor. Particularly, deriva ...
DOI:
10.1080/10286020.2017.1323885