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estrogen receptors; progesterone receptors, etc ; carcinoma; dogs; immunohistochemistry; Show all 5 Subjects
Abstract:
... We investigated the expression of oestrogen receptor alpha (OR-α), progesterone receptor (PR) and Akt in canine circumanal gland tumours. Immunohistochemistry was conducted on seven normal circumanal glands, 30 circumanal gland adenomas and 40 circumanal gland carcinomas. The expression of OR-α and PR was significantly lower in circumanal gland carcinomas than in circumanal gland adenomas. In cont ...
... Angiogenesis is a highly regulated process orchestrated, in large part, by the vascular endothelial growth factor-A (VEGF-A) system of ligands and receptors. Considerable effort has been invested in finding optimal ways to modulate VEGF-A activity to treat disease, however, the mechanisms by which the various components interact remain poorly understood. This is in part because of the difficulty o ...
... Maintaining endoplasmic reticulum (ER) homeostasis is essential for the production of biomolecules. ER retrieval, i.e., the retrograde transport of compounds from the Golgi to the ER, is one of the pathways that ensures ER homeostasis. However, the mechanisms underlying the regulation of ER retrieval in plants remain largely unknown. Plant ERD2‐like proteins (ERD2s) were recently suggested to func ...
receptors, etc ; human chorionic gonadotropin; luteinizing hormone; patients; pre-eclampsia; pregnancy; Show all 6 Subjects
Abstract:
... While human chorionic gonadotropin (hCG) appears to have an essential role in early pregnancy, it is controversial whether the hyperglycosylated form of hCG (hCG-h), which is the major hCG isoform during the first 4–5 weeks of pregnancy, is able to activate LH/hCG receptor (LHCGR). To address this, we utilized different extensively characterized hCG and hCGβ reference reagents, cell culture- and u ...
receptors; sensory receptors, etc ; humans; models; prediction; sensation; temperature; Show all 7 Subjects
Abstract:
... Physiologically, the thermal sensation/perception of human body is related to the response of cutaneous thermoreceptors (TRs) to the environment. However, the thermal response of skin warm and cold TRs is a function of two important factors: TRs temperatures and their time derivative at the subcutaneous locations of TRs. The available thermal models based on TRs response consider the same sensitiv ...
... The peptides orexin-A and −B, the endogenous agonists of the orexin receptors, have similar 19‐amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations successively reduce the activity. The peptides have been suggested to bind in an α‐helical conformation, and truncation beyond a certain critical length ...
... We describe the development of a nickel-catalyzed Suzuki–Miyaura cross-coupling of tertiary benzylic and allylic sulfones with arylboroxines. A variety of tertiary sulfones, which can easily be prepared via a deprotonation–alkylation route, were reacted to afford symmetric and unsymmetric quaternary products in good yields. We highlight the use of either BrettPhos or Doyle’s phosphines as effectiv ...
... Wet processes of phosphoric acids produce untreated wastewater containing large amounts of fluoride leading to serious environmental problems. This paper reports fundamental studies on two lower rim functionalised calix[4]arene based receptors namely 5, 11, 17, 23 tetra-tert-butyl, 25, 27 bis [diethylphenylurea]ethoxy, 26, 28 dihydroxycalix[4]arene, 1 and 25, 27 bis[diethylphenylurea]ethoxy, 26, 2 ...
taste receptors, etc ; electronic tongue; energy; hydrogen bonding; molecular models; monosodium glutamate; peptides; synergism; umami; Show all 9 Subjects
Abstract:
... In order to investigate the synergistic effect between umami peptides, monosodium glutamate (MSG) and the taste receptor T1R1/T1R3, a novel bivariate model was created based on our previous work. The results showed three specific changes upon the addition of MSG between umami peptides and T1R1/T1R3, in terms of energy and conformation. First, the addition of MSG enlarged the size of the binding ca ...
receptors, etc ; buildings; equations; prediction; quarries; vibration; Nigeria; Show all 7 Subjects
Abstract:
... The responses of adjoining structures to blast induced ground vibrations emanating from Kopek Construction Quarry, Ikere – Ekiti in Ekiti State were evaluated and predicted. Five off site receptors at predetermined distances from the blast source were chosen and the Peak Particle Velocity (PPV) at each receptor during blasting was estimated using the squared root scaled distance equation. The esti ...
receptors, etc ; ligands; liver; precision medicine; selection pressure; Show all 5 Subjects
Abstract:
... Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-related diseases. In addition, natural products are an interesting pool of potential ligands since they have been refined under evolutionary pressure to interact with proteins or other biological targets.This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid ...
Toll-like receptors, etc ; Schmidtea mediterranea; evolution; Show all 3 Subjects
Abstract:
... While genetic evidence points towards an absence of Toll-Like Receptors (TLRs) in Platyhelminthes, the Toll/IL-1 Receptor (TIR)-domains that drive the assembly of signalling complexes downstream TLR are present in these organisms. Here, we undertook the characterisation of the repertoire of TIR-domain containing proteins in Schmidtea mediterranea in order to gain valuable information on TLR evolut ...
receptors, etc ; immunity; phosphotransferases (kinases); plasma membrane; Show all 4 Subjects
Abstract:
... Plant receptor-like proteins (RLPs) are a family of transmembrane receptors which are distinguished from receptor-like kinases (RLKs) by their lack of a cytoplasmic kinase domain. RLPs continue to be implicated in a broad range of plant immunological and developmental processes as critical sensors or participants in receptor complexes on the plasma membrane. RLPs often associate with RLKs to activ ...
receptors, etc ; glycosylation; oligosaccharides; phosphorylation; protein transport; regioselectivity; Show all 6 Subjects
Abstract:
... Molecular recognition of mannose-6-phosphate (M6P)-modified oligosaccharides by transmembrane M6P receptors is a key signaling event in lysosomal protein trafficking in vivo. Access to M6P-containing high-mannose N-glycans is essential to achieving a thorough understanding of the M6P ligand–receptor recognition process. Herein we report the application of a versatile and reliable chemical strategy ...
peroxisome proliferator-activated receptors, etc ; drugs; ligands; screening; Show all 4 Subjects
Abstract:
... Affinity-based methods using immobilized proteins are important approaches for understanding the interactions between small molecules and biological targets. This review is intended to provide an overview of different affinity based separation methods that have been applied to the study of peroxisome proliferator activated receptors (PPARs). The screening of compound to increase screening rates fo ...
olfactory receptors, etc ; electronic nose; sensation; signal transduction; Show all 4 Subjects
Abstract:
... The present review describes recent advances in the development of an artificial nose system based on olfactory receptors and various sensing platforms. The kind of artificial nose, the production of olfactory receptors, the sensor platform for signal conversion and the application of the artificial nose system based on olfactory receptors and various sensing platforms are presented. The associate ...
nicotinic receptors, etc ; agonists; drugs; neurons; stoichiometry; therapeutics; Show all 6 Subjects
Abstract:
... The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional contribution of the β2 subunit, we generated heteromeric receptors with fixed stoichiometry by two different approaches comprising concatenated and unlinked subunits. Re ...
receptors, etc ; Orthoptera; abdomen; legs; posture; tibia; vibration; Show all 7 Subjects
Abstract:
... We investigate the influence of leg mechanics on the vibration input and function of vibrosensitive organs in the legs of the cave cricket Troglophilus neglectus, using laser Doppler vibrometry. By varying leg attachment, leg flexion, and body posture, we identify important influences on the amplitude and frequency parameters of transmitted vibrations. The legs respond best to relatively high-freq ...
receptors, etc ; biosensors; physicochemical properties; signal transduction; transistors; Show all 5 Subjects
Abstract:
... Molecular recognition, i.e., ability of one molecule to recognize another through weak bonding interactions, is one of the bases of life. It is often implemented to sensing systems of high merits. Preferential recognition of the analyte (guest) by the receptor (host) induces changes in physicochemical properties of the sensing system. These changes are measured by using suitable signal transducers ...
receptors, etc ; hydrophobicity; nuclear pore; nucleocytoplasmic transport; Show all 4 Subjects
Abstract:
... Nuclear pore complexes (NPCs) conduct nucleocytoplasmic transport through an FG domain-controlled barrier. We now explore how surface-features of a mobile species determine its NPC passage rate. Negative charges and lysines impede passage. Hydrophobic residues, certain polar residues (Cys, His), and, surprisingly, charged arginines have striking translocation-promoting effects. Favorable cation-π ...