PubAg

Main content area

You searched for: Subject "receptors" Remove constraint Subject: "receptors"
Start Over

Search

29,894  Search Results

« Previous | 1 - 20 of 29,894 |
Number of results to display per page

Search Results

1. Plant G proteins interact with endoplasmic reticulum luminal protein receptors to regulate endoplasmic reticulum retrieval

Author:
Wang, Shanshan; Xie, Ke; Xu, Guoyong; Zhou, Huarui; Guo, Qiang; Wu, Jingyi; Liao, Zengwei; Liu, Na; Wang, Yan; Liu, Yule
Source:
Journal of integrative plant biology 2018 v.60 no.7 pp. 541-561
ISSN:
1672-9072
Subject:
receptors,   etc   ; endoplasmic reticulum; homeostasis;     Show all 3 Subjects
Abstract:
... Maintaining endoplasmic reticulum (ER) homeostasis is essential for the production of biomolecules. ER retrieval, i.e., the retrograde transport of compounds from the Golgi to the ER, is one of the pathways that ensures ER homeostasis. However, the mechanisms underlying the regulation of ER retrieval in plants remain largely unknown. Plant ERD2‐like proteins (ERD2s) were recently suggested to func ...
DOI:
10.1111/jipb.12648

2. Stapled truncated orexin peptides as orexin receptor agonists

Author:
Karhu, Lasse; Weisell, Janne; Turunen, Pauli M.; Leino, Teppo O.; Pätsi, Henri; Xhaard, Henri; Kukkonen, Jyrki P.; Wallén, Erik A.A.
Source:
Peptides 2018 v.102 pp. 54-60
ISSN:
0196-9781
Subject:
receptors,   etc   ; agonists; amino acids; peptides;     Show all 4 Subjects
Abstract:
... The peptides orexin-A and −B, the endogenous agonists of the orexin receptors, have similar 19‐amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations successively reduce the activity. The peptides have been suggested to bind in an α‐helical conformation, and truncation beyond a certain critical length ...
DOI:
10.1016/j.peptides.2018.02.004

3. Preparation of Quaternary Centers via Nickel-Catalyzed Suzuki–Miyaura Cross-Coupling of Tertiary Sulfones

Author:
Ariki, Zachary T.; Maekawa, Yuuki; Nambo, Masakazu; Crudden, Cathleen M.
Source:
Journal of the American Chemical Society 2018 v.140 no.1 pp. 78-81
ISSN:
1520-5126
Subject:
calcitriol receptors,   etc   ; Suzuki reaction; ligands;     Show all 3 Subjects
Abstract:
... We describe the development of a nickel-catalyzed Suzuki–Miyaura cross-coupling of tertiary benzylic and allylic sulfones with arylboroxines. A variety of tertiary sulfones, which can easily be prepared via a deprotonation–alkylation route, were reacted to afford symmetric and unsymmetric quaternary products in good yields. We highlight the use of either BrettPhos or Doyle’s phosphines as effectiv ...
DOI:
10.1021/jacs.7b10855

4. Synthesis of high-mannose oligosaccharides containing mannose-6-phosphate residues using regioselective glycosylation

Author:
Meng, Bo; Wang, Jun; Wang, Quanli; Serianni, Anthony S.; Pan, Qingfeng
Source:
Carbohydrate research 2018 v.467 pp. 23-32
ISSN:
0008-6215
Subject:
receptors,   etc   ; glycosylation; oligosaccharides; phosphorylation; protein transport; regioselectivity;     Show all 6 Subjects
Abstract:
... Molecular recognition of mannose-6-phosphate (M6P)-modified oligosaccharides by transmembrane M6P receptors is a key signaling event in lysosomal protein trafficking in vivo. Access to M6P-containing high-mannose N-glycans is essential to achieving a thorough understanding of the M6P ligand–receptor recognition process. Herein we report the application of a versatile and reliable chemical strategy ...
DOI:
10.1016/j.carres.2018.07.005

5. An overview of an artificial nose system

Author:
Zhang, Xiu; Cheng, Jing; Wu, Lei; Mei, Yong; Jaffrezic-Renault, Nicole; Guo, Zhenzhong
Source:
Talanta 2018 v.184 pp. 93-102
ISSN:
0039-9140
Subject:
olfactory receptors,   etc   ; electronic nose; sensation; signal transduction;     Show all 4 Subjects
Abstract:
... The present review describes recent advances in the development of an artificial nose system based on olfactory receptors and various sensing platforms. The kind of artificial nose, the production of olfactory receptors, the sensor platform for signal conversion and the application of the artificial nose system based on olfactory receptors and various sensing platforms are presented. The associate ...
DOI:
10.1016/j.talanta.2018.02.113

6. Molecular function of the novel α7β2 nicotinic receptor

Author:
Nielsen, BeatrizE.; Minguez, Teresa; Bermudez, Isabel; Bouzat, Cecilia
Source:
Cellular and molecular life sciences 2018 v.75 no.13 pp. 2457-2471
ISSN:
1420-682X
Subject:
nicotinic receptors,   etc   ; agonists; drugs; neurons; stoichiometry; therapeutics;     Show all 6 Subjects
Abstract:
... The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional contribution of the β2 subunit, we generated heteromeric receptors with fixed stoichiometry by two different approaches comprising concatenated and unlinked subunits. Re ...
DOI:
10.1007/s00018-017-2741-4

7. The mechanical leg response to vibration stimuli in cave crickets and implications for vibrosensory organ functions A Neuroethology, sensory, neural, and behavioral physiology

Author:
Stritih Peljhan, Nataša; Strauß, Johannes
Source:
Journal of comparative physiology 2018 v.204 no.7 pp. 687-702
ISSN:
0340-7594
Subject:
receptors,   etc   ; Orthoptera; abdomen; legs; posture; tibia; vibration;     Show all 7 Subjects
Abstract:
... We investigate the influence of leg mechanics on the vibration input and function of vibrosensitive organs in the legs of the cave cricket Troglophilus neglectus, using laser Doppler vibrometry. By varying leg attachment, leg flexion, and body posture, we identify important influences on the amplitude and frequency parameters of transmitted vibrations. The legs respond best to relatively high-freq ...
DOI:
10.1007/s00359-018-1271-3

8. Molecular recognition by synthetic receptors: Application in field-effect transistor based chemosensing

Author:
Iskierko, Zofia; Noworyta, Krzysztof; Sharma, Piyush Sindhu
Source:
Biosensors & bioelectronics 2018 v.109 pp. 50-62
ISSN:
0956-5663
Subject:
receptors,   etc   ; biosensors; physicochemical properties; signal transduction; transistors;     Show all 5 Subjects
Abstract:
... Molecular recognition, i.e., ability of one molecule to recognize another through weak bonding interactions, is one of the bases of life. It is often implemented to sensing systems of high merits. Preferential recognition of the analyte (guest) by the receptor (host) induces changes in physicochemical properties of the sensing system. These changes are measured by using suitable signal transducers ...
DOI:
10.1016/j.bios.2018.02.058

9. Surface Properties Determining Passage Rates of Proteins through Nuclear Pores

Author:
Frey, Steffen; Rees, Renate; Schünemann, Jürgen; Ng, Sheung Chun; Fünfgeld, Kevser; Huyton, Trevor; Görlich, Dirk
Source:
Cell 2018 v.174 no.1 pp. 202-217.e9
ISSN:
0092-8674
Subject:
receptors,   etc   ; hydrophobicity; nuclear pore; nucleocytoplasmic transport;     Show all 4 Subjects
Abstract:
... Nuclear pore complexes (NPCs) conduct nucleocytoplasmic transport through an FG domain-controlled barrier. We now explore how surface-features of a mobile species determine its NPC passage rate. Negative charges and lysines impede passage. Hydrophobic residues, certain polar residues (Cys, His), and, surprisingly, charged arginines have striking translocation-promoting effects. Favorable cation-π ...
DOI:
10.1016/j.cell.2018.05.045

10. Design of a Highly Bistable Photoswitchable Tethered Ligand for Rapid and Sustained Manipulation of Neurotransmission

Author:
Lin, Wan-Chen; Tsai, Ming-Chi; Rajappa, Rajit; Kramer, Richard H.
Source:
Journal of the American Chemical Society 2018 v.140 no.24 pp. 7445-7448
ISSN:
1520-5126
Subject:
neurotransmitter receptors,   etc   ; brain; cultured cells; ligands; optogenetics;     Show all 5 Subjects
Abstract:
... Photoswitchable neurotransmitter receptors are powerful tools for precise manipulation of neural signaling. However, their applications for slow or long-lasting biological events are constrained by fast thermal relaxation of cis-azobenzene. We address this issue by modifying the ortho positions of azobenzene used in the tethered ligand. In cultured cells and intact brain tissue, conjugating inhibi ...
DOI:
10.1021/jacs.8b03942

11. De novo assembly, gene annotation, and marker development using Illumina paired-end transcriptome sequencing in the Crassadoma gigantea

Author:
Cao, Shanmao; Zhu, Lijie; Nie, Hongtao; Yin, Minghao; Liu, Gang; Yan, Xiwu
Source:
Gene 2018 v.658 pp. 54-62
ISSN:
0378-1119
Subject:
Toll-like receptor 1; Toll-like receptor 2; Toll-like receptor 3,   etc   ; DNA repair; Toll-like receptor 4; Toll-like receptor 5; Toll-like receptor 6; Toll-like receptor 7; Toll-like receptor 8; Toll-like receptor 9; alleles; conservation genetics; heterozygosity; microsatellite repeats; population structure; sequence analysis; somatomedins; transcriptome; transcriptomics; Mexico;     Show all 20 Subjects
Abstract:
... Crassadoma gigantea is an important commercial marine bivalve species in Baja California and Mexico. In this study, we have applied RNA-Seq technology to profile the transcriptome of the C. gigantea for the first time. A total of 80,832,518 raw reads were produced from a Illumina HiSeq4000 platform, and 77,306,198 (95.64%) clean reads were generated after trimming the adaptor sequences. The transc ...
DOI:
10.1016/j.gene.2018.03.019

12. Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level

Author:
Fischer, Jana; Kleinau, Gunnar; Rutz, Claudia; Zwanziger, Denise; Khajavi, Noushafarin; Müller, Anne; Rehders, Maren; Brix, Klaudia; Worth, CatherineL.; Führer, Dagmar; Krude, Heiko; Wiesner, Burkhard; Schülein, Ralf; Biebermann, Heike
Source:
Cellular and molecular life sciences 2018 v.75 no.12 pp. 2227-2239
ISSN:
1420-682X
Subject:
thyrotropin receptors,   etc   ; plasma membrane; spectroscopy; thyroid hormones;     Show all 4 Subjects
Abstract:
... G-protein-coupled receptors (GPCRs) can constitute complexes with non-GPCR integral membrane proteins, while such interaction has not been demonstrated at a single molecule level so far. We here investigated the potential interaction between the thyrotropin receptor (TSHR) and the monocarboxylate transporter 8 (MCT8), a member of the major facilitator superfamily (MFS), using fluorescence cross-co ...
DOI:
10.1007/s00018-017-2728-1

13. Transient Acceleration of Epidermal Growth Factor Receptor Dynamics Produces Higher-Order Signaling Clusters

Author:
Hiroshima, Michio; Pack, Chan-gi; Kaizu, Kazunari; Takahashi, Koichi; Ueda, Masahiro; Sako, Yasushi
Source:
Journal of molecular biology 2018 v.430 pp. 1386-1401
ISSN:
0022-2836
Subject:
epidermal growth factor receptors,   etc   ; dimerization; phosphorylation;     Show all 3 Subjects
Abstract:
... Cell signaling depends on spatiotemporally regulated molecular interactions. Although the movements of signaling proteins have been analyzed with various technologies, how spatial dynamics influence the molecular interactions that transduce signals is unclear. Here, we developed a single-molecule method to analyze the spatiotemporal coupling between motility, clustering, and signaling. The analysi ...
DOI:
10.1016/j.jmb.2018.02.018

14. Listening in the bog: II. Neural correlates for acoustic interactions and spacing between Sphagniana sphagnorum males A Neuroethology, sensory, neural, and behavioral physiology

Author:
Kostarakos, Konstantinos; Römer, Heiner
Source:
Journal of comparative physiology 2018 v.204 no.4 pp. 353-367
ISSN:
0340-7594
Subject:
receptors,   etc   ; Tettigoniidae; acoustics; interneurons; males; sympatry; ultrasonics;     Show all 7 Subjects
Abstract:
... Males of the katydid Sphagniana sphagnorum maintain inter-male distances from one another using agonistic song interactions with a frequency-modulated song that consists of alternating audio and ultrasonic parts. We studied the neuronal representation of this song in auditory receptors and interneurons of receivers, using playbacks of songs that mimicked the absolute and relative sound pressure le ...
DOI:
10.1007/s00359-018-1251-7

15. Praziquantel Interaction with Mammalian Targets in the Spotlight

Author:
Day, Tim A.; Kimber, Michael J.
Source:
Trends in parasitology 2018 v.34 pp. 263-265
ISSN:
1471-4922
Subject:
receptors,   etc   ; drugs; humans; mice; praziquantel; therapeutics;     Show all 6 Subjects
Abstract:
... Chan et al. recently demonstrated that the antischistosomal drug praziquantel has a potent and specific interaction with human 5-HT2B receptors, and that the drug also elicits contraction of mouse mesenteric vasculature apparently mediated by the same receptor subtype We consider what this might mean about the drug’s molecular therapeutic targets in both the worm and the host. ...
DOI:
10.1016/j.pt.2018.01.006

16. The Single-Molecule Centroid Localization Algorithm Improves the Accuracy of Fluorescence Binding Assays

Author:
Hua, Boyang; Wang, Yanbo; Park, Seongjin; Han, Kyu Young; Singh, Digvijay; Kim, Jin H.; Cheng, Wei; Ha, Taekjip
Source:
Biochemistry 2018 v.57 no.10 pp. 1572-1576
ISSN:
1520-4995
Subject:
receptors,   etc   ; DNA; algorithms; fluorescence; immunoglobulin G; protocols;     Show all 6 Subjects
Abstract:
... Here, we demonstrate that the use of the single-molecule centroid localization algorithm can improve the accuracy of fluorescence binding assays. Two major artifacts in this type of assay, i.e., nonspecific binding events and optically overlapping receptors, can be detected and corrected during analysis. The effectiveness of our method was confirmed by measuring two weak biomolecular interactions, ...
DOI:
10.1021/acs.biochem.7b01293

17. Light and temperature cues: multitasking receptors and transcriptional integrators

Author:
Casal, Jorge J.; Qüesta, Julia I.
Source:
Thenew phytologist 2018 v.217 no.3 pp. 1029-1034
ISSN:
0028-646X
Subject:
receptors,   etc   ; epigenetics; physiology; phytochrome; temperature; transcription (genetics);     Show all 6 Subjects
Abstract:
... Contents Summary 1029 I. Introduction 1029 II. Convergence at the receptor 1030 III. Convergence at transcriptional hubs 1031 IV. Convergence involving clock components 1033 V. Conclusions 1033 Acknowledgements 1033 References 1033 SUMMARY: The combined information provided by light and temperature cues helps to optimise plant body architecture and physiology. Plants possess elaborate systems to s ...
DOI:
10.1111/nph.14890

18. The nucleotide‐free state of heterotrimeric G proteins α‐subunit adopts a highly stable conformation

Author:
Andhirka, Sai Krishna; Vignesh, Ravichandran; Aradhyam, Gopala Krishna
Source:
The FEBS journal 2017 v.284 no.15 pp. 2464-2481
ISSN:
1742-464X
Subject:
receptors,   etc   ; crystal structure; guanine;     Show all 3 Subjects
Abstract:
... Deciphering the mechanism of activation of heterotrimeric G proteins by their cognate receptors continues to be an intriguing area of research. The recently solved crystal structure of the ternary complex captured the receptor‐bound α‐subunit in an open conformation, without bound nucleotide has improved our understanding of the activation process. Despite these advancements, the mechanism by whic ...
DOI:
10.1111/febs.14143

19. Porphyrinoids for Chemical Sensor Applications

Author:
Paolesse, Roberto; Nardis, Sara; Monti, Donato; Stefanelli, Manuela; Di Natale, Corrado
Source:
Chemical Reviews 2017 v.117 no.4 pp. 2517-2583
ISSN:
1520-6890
Subject:
receptors,   etc   ; liquids; porphyrins;     Show all 3 Subjects
Abstract:
... Porphyrins and related macrocycles have been intensively exploited as sensing materials in chemical sensors, since in these devices they mimic most of their biological functions, such as reversible binding, catalytic activation, and optical changes. Such a magnificent bouquet of properties allows applying porphyrin derivatives to different transducers, ranging from nanogravimetric to optical devic ...
DOI:
10.1021/acs.chemrev.6b00361

20. Vesicles Spread Susceptibility to Phages

Author:
Ofir, Gal; Sorek, Rotem
Source:
Cell 2017 v.168 pp. 13-15
ISSN:
0092-8674
Subject:
virus receptors,   etc   ; bacteria; bacteriophages;     Show all 3 Subjects
Abstract:
... Extracellular membrane vesicles from bacteria are now shown to transfer phage receptors from susceptible to resistant cells, thus making them transiently sensitive to phage infection (Tzipilevich et al.). ...
DOI:
10.1016/j.cell.2016.12.035