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1. Transient Acceleration of Epidermal Growth Factor Receptor Dynamics Produces Higher-Order Signaling Clusters

Author:
Hiroshima, Michio; Pack, Chan-gi; Kaizu, Kazunari; Takahashi, Koichi; Ueda, Masahiro; Sako, Yasushi
Source:
Journal of molecular biology 2018 v.430 pp. 16-1401
ISSN:
0022-2836
Subject:
epidermal growth factor receptors,   etc   ; dimerization; phosphorylation;     Show all 3 Subjects
Abstract:
... Cell signaling depends on spatiotemporally regulated molecular interactions. Although the movements of signaling proteins have been analyzed with various technologies, how spatial dynamics influence the molecular interactions that transduce signals is unclear. Here, we developed a single-molecule method to analyze the spatiotemporal coupling between motility, clustering, and signaling. The analysi ...
DOI:
10.1016/j.jmb.2018.02.018

2. Vesicles Spread Susceptibility to Phages

Author:
Ofir, Gal; Sorek, Rotem
Source:
Cell 2017 v.168 pp. 13-15
ISSN:
0092-8674
Subject:
virus receptors,   etc   ; bacteria; bacteriophages;     Show all 3 Subjects
Abstract:
... Extracellular membrane vesicles from bacteria are now shown to transfer phage receptors from susceptible to resistant cells, thus making them transiently sensitive to phage infection (Tzipilevich et al.). ...
DOI:
10.1016/j.cell.2016.12.035

3. Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes

Author:
Macri, Christophe; Dumont, Claire; Panozza, Scott; Lahoud, Mireille H.; Caminschi, Irina; Villadangos, Jose A.; Johnston, Angus P.R.; Mintern, Justine D.
Source:
Molecular Immunology 2017 v.81 pp. 143-150
ISSN:
0161-5890
Subject:
receptors,   etc   ; antigens; mice; vaccination;     Show all 4 Subjects
Abstract:
... Targeting antigen (Ag) to dendritic cell (DC) surface receptors is a potential new mode of vaccination. C-type lectin-like receptors Clec9A and Clec12A are attractive receptor targets however their targeting in vivo elicits significantly different outcomes for unknown reasons. To gain insight into the mechanisms responsible, we have examined the intrinsic capacity of Clec9A and Clec12A to elicit M ...
DOI:
10.1016/j.molimm.2016.12.010

4. Efficient synthesis of 3-benzoyl Benzo[b]thiophenes and raloxifene via Mercury(II)-Catalyzed cyclization of 2-alkynylphenyl alkyl sulfoxides

Author:
Wen, Shi-Ming; Lin, Cheng-Han; Chen, Chin-Chau; Wu, Ming-Jung
Source:
Tetrahedron 2018 v.74 pp. 7-2499
ISSN:
0040-4020
Subject:
estrogen receptors,   etc   ; alkylation; cyclization reactions; mercury; moieties; organobromine compounds; thiophenes;     Show all 7 Subjects
Abstract:
... The unique selective estrogen receptor modulator, Raloxifene (1), and antitubulin agent 2 were synthesized through the key intermediate, 4-methoxybenzyl 2-bromo-4-methoxyphenyl sulfoxide (6), respectively. It was found that compared with the o-sulfanyl aryl bromides, the sulfinyl group at ortho position accelerated the Sonogashira coupling reaction of aryl bromides. Thus, compound 6 was coupled wi ...
DOI:
10.1016/j.tet.2018.03.067

5. Advances in the role of oxytocin receptors in human parturition

Author:
Kim, Sung Hye; Bennett, Phillip R.; Terzidou, Vasso
Source:
Molecular and Cellular Endocrinology 2017
ISSN:
0303-7207
Subject:
G-protein coupled receptors; oxytocin receptors,   etc   ; inflammation; microRNA; oxytocin; parturition;     Show all 6 Subjects
Abstract:
... Oxytocin (OT) is a neurohypophysial hormone which has been found to play a central role in the regulation of human parturition. The most established role of oxytocin/oxytocin receptor (OT/OTR) system in human parturition is the initiation of uterine contractions, however, recent evidence have demonstrated that it may have a more complex role including initiation of inflammation, regulation of miRN ...
DOI:
10.1016/j.mce.2017.01.034

6. Membrane-induced organization and dynamics of the N-terminal domain of chemokine receptor CXCR1: insights from atomistic simulations

Author:
Kharche, Shalmali; Joshi, Manali; Sengupta, Durba; Chattopadhyay, Amitabha
Source:
Chemistry and physics of lipids 2017
ISSN:
0009-3084
Subject:
CXCR1 receptor,   etc   ; cell membranes; ligands;     Show all 3 Subjects
Abstract:
... The CXC chemokine receptor 1 (CXCR1) is an important member of the G protein-coupled receptor (GPCR) family in which the extracellular N-terminal domain has been implicated in ligand binding and selectivity. The structure of this domain has not yet been elucidated due to its inherent dynamics, but experimental evidence points toward membrane-dependent organization and dynamics. To gain molecular i ...
DOI:
10.1016/j.chemphyslip.2017.09.003

7. Synergistic effect of co-stimulation of membrane and endosomal TLRs on chicken innate immune responses

Author:
Kim, Sungwon; Kaiser, Pete; Borowska, Dominika; Vervelde, Lonneke
Source:
Veterinary immunology and immunopathology 2018 v.199 pp. 7-21
ISSN:
0165-2427
Subject:
Toll-like receptor 2; Toll-like receptor 4; Toll-like receptor 7,   etc   ; cell death; cell proliferation; chickens; genes; innate immunity; interleukin-10; interleukin-12; interleukin-1beta; ligands; lipid A; macrophages; mammals; messenger RNA; nitric oxide; splenocytes; synergism; vaccine adjuvants;     Show all 20 Subjects
Abstract:
... Toll-like receptor (TLR) ligands (TLR-Ls) are critical activators of immunity and are successfully being developed as vaccine adjuvants in both mammals and birds. In this study, we investigated the synergistic effect of co-stimulation of membrane and endosomal TLRs on the innate immune responses using chicken bone marrow-derived macrophages (BMMs), and studied the effect of age on the induction of ...
DOI:
10.1016/j.vetimm.2018.03.005

8. Toll-like receptor expression and apoptosis morphological patterns in female rat hearts with takotsubo syndrome induced by isoprenaline

Author:
Kołodzińska, Agnieszka; Czarzasta, Katarzyna; Szczepankiewicz, Benedykt; Główczyńska, Renata; Fojt, Anna; Ilczuk, Tomasz; Budnik, Monika; Krasuski, Krzysztof; Folta, Miłosz; Cudnoch-Jędrzejewska, Agnieszka; Górnicka, Barbara; Opolski, Grzegorz
Source:
Life sciences 2018 v.199 pp. 10-121
ISSN:
0024-3205
Subject:
Toll-like receptor 2; Toll-like receptor 4; Toll-like receptor 6,   etc   ; apoptosis; cardiomyocytes; endothelial cells; females; heart failure; innate immunity; isoprenaline; macrophages; messenger RNA; models; pathophysiology; protein synthesis; rats; sodium chloride;     Show all 17 Subjects
Abstract:
... Toll-like receptors (TLR) and apoptosis were indicated as important factors in heart failure. Our aim was to characterize the morphological pattern of apoptosis, TLR2, TLR4, and TLR6 expression in female rat hearts in the model of takotsubo syndrome (TTS).60 Sprague-Dawley female rats were treated with a single dose of 150 mg/kg b.wt. of isoprenaline (ISO) or 0.9% NaCl (controls). Hearts were coll ...
DOI:
10.1016/j.lfs.2018.02.042

9. Expression of receptor tyrosine kinase targets PDGFR‐β, VEGFR2 and KIT in canine transitional cell carcinoma

Author:
Walters, L.; Martin, O.; Price, J.; Sula, M. M.
Source:
Veterinary and comparative oncology 2018 v.16 no.1 pp. E117-E122
ISSN:
1476-5810
Subject:
platelet-derived growth factor receptor beta; vascular endothelial growth factor receptor-2,   etc   ; bladder; cell growth; cystitis; dogs; metastasis; neoplasms; phosphates; staining; stem cell factor;     Show all 11 Subjects
Abstract:
... Transitional cell carcinoma (TCC) is the most common neoplasia of the canine urinary tract. It tends to be locally invasive and has a moderate metastatic rate. Receptor tyrosine kinases (RTKs) play an important role in promoting cell growth, differentiation and regulation of cell function. RTK inhibitor toceranib phosphate has been used anecdotally to treat TCC. The goal of this study was to evalu ...
DOI:
10.1111/vco.12344

10. Vitamin D receptor expression in canine mammary gland and relationship with clinicopathological parameters and progesterone/oestrogen receptors

Author:
Sánchez‐Céspedes, R.; Fernández‐Martínez, M. D.; Raya, A.; Pineda, C.; López, I.; Millán, Y.
Source:
Veterinary and comparative oncology 2018 v.16 no.1 pp. E185-E193
ISSN:
1476-5810
Subject:
calcitriol receptors; estrogen receptors,   etc   ; angiogenesis; animal tissues; apoptosis; breast neoplasms; calcitriol; dogs; epithelial cells; females; humans; immunohistochemistry; ligands; mammary glands; mammary neoplasms (animal); metastasis; models; progesterone; staining; therapeutics;     Show all 20 Subjects
Abstract:
... The vitamin D receptor (VDR) belongs to the nuclear class II receptor family. VDR is a ligand transcription factor and mediates the actions of calcitriol, the active product of vitamin D synthesis. Nowadays, it is known that the biological actions of calcitriol include the capacity to modulate cancer features, such as proliferation and differentiation, apoptosis, angiogenesis, invasion and metasta ...
DOI:
10.1111/vco.12371

11. Simulated photoperiod influences testicular activity in quail via modulating local GnRHR-GnIHR, GH-R, Cnx-43 and 14-3-3 B Biology

Author:
Banerjee, Somanshu; Chaturvedi, Chandra Mohini
Source:
Journal of photochemistry and photobiology 2018 v.178 pp. 12-423
ISSN:
1011-1344
Subject:
androgen receptors; somatotropin receptors,   etc   ; autocrine signaling; epididymis; gonadotropin-releasing hormone; messenger RNA; photoperiod; photosensitivity; proliferating cell nuclear antigen; quails; steroidogenesis; steroidogenic acute regulatory protein; testes; testosterone;     Show all 14 Subjects
Abstract:
... The hypothalamo-hypophyseal-gonadal axis mediated differential photosexual responses in quail kept under different simulated photoperiodic conditions have been studied in details. Local testicular GnRH-GnIH and their receptor system has been hypothesized to be modulated in quail showing different photo-sexual responses and thus influence the testicular activity and steroidogenesis through local (p ...
DOI:
10.1016/j.jphotobiol.2017.11.034

12. The variable lymphocyte receptor as an antibody alternative

Author:
Waters, Elizabeth A; Shusta, Eric V
Source:
Current opinion in biotechnology 2018 v.52 pp. 6-79
ISSN:
0958-1669
Subject:
receptors,   etc   ; antibodies; antigens; diagnostic techniques; directed evolution; drugs; immunization; lymphocytes; polysaccharides; protein engineering; vertebrates;     Show all 11 Subjects
Abstract:
... Variable lymphocyte receptors (VLRs) are leucine-rich repeat proteins in jawless vertebrates that function similarly to Ig antibodies. However, VLRs possess a distinct crescent-shaped structure and modularity that results in a concave binding interface that contrasts significantly with Ig antibodies. Antigen binding interactions result in specific, high affinity VLR binding interactions with both ...
DOI:
10.1016/j.copbio.2018.02.016

13. Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities

Author:
Belfiore, Lisa; Saunders, Darren N.; Ranson, Marie; Thurecht, Kristofer J.; Storm, Gert; Vine, Kara L.
Source:
Journal of controlled release 2018 v.277 pp. 13-13
ISSN:
0168-3659
Subject:
receptors,   etc   ; antineoplastic activity; drug carriers; drug formulations; drugs; ligands; models; neoplasm cells; neoplasms; stromal cells; toxicity;     Show all 11 Subjects
Abstract:
... The development of therapeutic resistance to targeted anticancer therapies remains a significant clinical problem, with intratumoral heterogeneity playing a key role. In this context, improving the therapeutic outcome through simultaneous targeting of multiple tumor cell subtypes within a heterogeneous tumor is a promising approach. Liposomes have emerged as useful drug carriers that can reduce sy ...
DOI:
10.1016/j.jconrel.2018.02.040

14. Changes in expression of P2X7 receptors in rat myometrium at different gestational stages and the mechanism of ATP-induced uterine contraction

Author:
Alotaibi, Mohammed
Source:
Life sciences 2018 v.199 pp. 7-157
ISSN:
0024-3205
Subject:
receptors,   etc   ; adenosine triphosphate; calcium; enzyme-linked immunosorbent assay; myometrium; pregnancy; rats; uterine contraction;     Show all 8 Subjects
Abstract:
... Given the importance of ATP in the control of uterine activity for successful labor and involution, this study was performed to measure the level of P2X7 receptors (P2X7Rs) in rat myometrium at different gestational stages and to investigate the mechanisms of ATP-induced uterine contraction.Myometrial tissues were obtained from rats at different gestational stages and the level of P2X7Rs was measu ...
DOI:
10.1016/j.lfs.2018.03.016

15. Axl inhibitors as novel cancer therapeutic agents

Author:
Shen, Yingying; Chen, Xiguang; He, Jun; Liao, Duanfang; Zu, Xuyu
Source:
Life sciences 2018 v.198 pp. 13-111
ISSN:
0024-3205
Subject:
receptor protein-tyrosine kinase,   etc   ; breasts; cell proliferation; drug therapy; drugs; humans; lungs; metastasis; pancreatic neoplasms; patients;     Show all 10 Subjects
Abstract:
... Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain d ...
DOI:
10.1016/j.lfs.2018.02.033

16. Noncritical Signaling Role of a Kinase–Receptor Interaction Surface in the Escherichia coli Chemosensory Core Complex

Author:
Piñas, Germán E.; DeSantis, Michael D.; Parkinson, John S.
Source:
Journal of molecular biology 2018 v.430 pp. 14-1064
ISSN:
0022-2836
Subject:
receptors,   etc   ; Escherichia coli; chemoreceptors; chemotaxis; crosslinking; enzyme activity; histidine; hydrophobicity; models; scaffolding proteins; serine;     Show all 11 Subjects
Abstract:
... In Escherichia coli chemosensory arrays, transmembrane receptors, a histidine autokinase CheA, and a scaffolding protein CheW interact to form an extended hexagonal lattice of signaling complexes. One interaction, previously assigned a crucial signaling role, occurs between chemoreceptors and the CheW-binding P5 domain of CheA. Structural studies showed a receptor helix fitting into a hydrophobic ...
DOI:
10.1016/j.jmb.2018.02.004

17. Reasons to Be Nervous about Flukicide Discovery

Author:
McVeigh, Paul; McCusker, Paul; Robb, Emily; Wells, Duncan; Gardiner, Erica; Mousley, Angela; Marks, Nikki J.; Maule, Aaron G.
Source:
Trends in parasitology 2018 v.34 pp. 13-196
ISSN:
1471-4922
Subject:
G-protein coupled receptors,   etc   ; Fasciola hepatica; Nematoda; anthelmintics; drugs; immunocytochemistry; liver flukes; neuropeptides; neurophysiology;     Show all 9 Subjects
Abstract:
... The majority of anthelmintics dysregulate neuromuscular function, a fact most prominent for drugs against nematode parasites. In contrast to the strong knowledge base for nematode neurobiology, resource and tool deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, immunocytochemistry, and neuropeptide biochemistry 20–30 years ago. However, recent develop ...
DOI:
10.1016/j.pt.2017.11.010

18. Correction to: Cell type-specific localization of Ephs pairing with ephrin-B2 in the rat postnatal pituitary gland

Author:
Yoshida, Saishu; Kato, Takako; Kanno, Naoko; Nishimura, Naoto; Nishihara, Hiroto; Horiguchi, Kotaro; Kato, Yukio
Source:
Cell and tissue research 2018 v.371 no.2 pp. 3-387
ISSN:
0302-766X
Subject:
receptor protein-tyrosine kinase,   etc   ; cell fusion; neonatal development; pituitary gland; rats;     Show all 5 Subjects
Abstract:
... The published online version contains mistakes in Table 1, Table 2 and Fig. 2. See below for the corrected Tables and Figure. ...
DOI:
10.1007/s00441-017-2721-x

19. GID1 expression is associated with ovule development of sexual and apomictic plants

Author:
Ferreira, LucianaGomes; de Alencar Dusi, DivaMaria; Irsigler, AndréSouthernman Teixeira; Gomes, AnaCristina Meneses Mendes; Mendes, MartaAdelina; Colombo, Lucia; de Campos Carneiro, VeraTavares
Source:
Plant cell reports 2018 v.37 no.2 pp. 14-306
ISSN:
0721-7714
Subject:
receptors,   etc   ; Arabidopsis thaliana; Urochloa brizantha; embryo sac; genes; gibberellins; megasporocytes; megasporogenesis; nucellus;     Show all 9 Subjects
Abstract:
... KEY MESSAGE: BbrizGID1 is expressed in the nucellus of apomictic Brachiaria brizantha, previous to aposporous initial differentiation. AtGID1a overexpression triggers differentiation of Arabidopsis thaliana MMC-like cells, suggesting its involvement in ovule development. GIBBERELLIN-INSENSITIVE DWARF1 (GID1) is a gibberellin receptor previously identified in plants and associated with reproductive ...
DOI:
10.1007/s00299-017-2230-0

20. Numerical analysis of lightning attachment to wind turbine blade

Author:
Zhou, Qibin; Liu, Canxiang; Bian, Xiaoyan; Lo, Kwok L.; Li, Dongdong
Source:
Renewable energy 2018 v.116 pp. 584-593
ISSN:
0960-1481
Subject:
receptors,   etc   ; blades; finite element analysis; lightning; renewable energy sources; wind turbines;     Show all 6 Subjects
Abstract:
... In order to study lightning attachment characteristic of wind turbine blades, a method is proposed in this paper by using electrostatic simulation to analyze the development mechanism of the line lightning leader to establish the lightning initial attachment zones. A full-size turbine blade and a downward leader is modelled to investigate the lightning attachment characteristic by using 3D electro ...
DOI:
10.1016/j.renene.2017.09.086