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... Mepanipyrim, an anilinopyrimidine fungicide, has been extensively used to prevent fungal diseases in fruit culture. Currently, research on mepanipyrim-induced toxicity in organisms is still very scarce, especially visual developmental toxicity. Here, zebrafish larvae were employed to investigate mepanipyrim-induced visual developmental toxicity. Intense light and monochromatic light stimuli-evoked ...
androgen receptors; aryl hydrocarbon receptors; estrogen receptors, etc ; bioassays; chemical analysis; heterocyclic compounds; hormone antagonists; toxic substances; toxicity; Show all 9 Subjects
Abstract:
... Tire granulates recovered from end-of-life tires contain a complex mixture of chemicals, amongst them polyaromatic compounds (PACs), of which many are recognized to be toxic and persistent in the environment. Only a few of these PACs are regularly monitored. In this study a combined approach of chemical analysis and a battery of CALUX® in vitro bioassays was used to determine PAC concentrations an ...
... Epidemiological studies have shown the presence of triclosan (TCS) in the brain due to its widespread use as an antibacterial ingredient. One of the confirmed mechanisms of its action is the interaction with the aryl hydrocarbon receptor (AhR). In nerve cells, sirtuins (Sirt1 and Sirt3) act as cellular sensors detecting energy availability and modulate metabolic processes. Moreover, it has been fo ...
estrogen receptors; taste receptors; virus receptors, etc ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; humans; rodents; smell; taste; transient receptor potential vanilloid channels; Show all 10 Subjects
Abstract:
... In addition to the α, β, and γ subunits of ENaC, human salt-sensing taste receptor cells (TRCs) also express the δ-subunit. At present, it is not clear if the expression and function of the ENaC δ-subunit in human salt-sensing TRCs is also modulated by the ENaC regulatory hormones and intracellular signaling effectors known to modulate salt responses in rodent TRCs. Here, we used molecular techniq ...
androgen receptors; estrogen receptors, etc ; androgens; estrogens; logit analysis; phthalates; prediction; risk assessment; transcriptional activation; Show all 9 Subjects
Abstract:
... Unlike the environmental pollutants or industrial chemicals, the chemicals in consumer products may pose higher levels of risks, depending on how the chemicals are used in the products and how humans interact with the products. Recently, endocrine disrupting chemicals in cosmetics, personal care products, cleaners, sunscreens, and vinyl products were analytically quantified and many active chemica ...
... Ringed seals (Pusa hispida) are slowly recovering in the eastern and northern parts of the Baltic Sea after years of hunting pressure and contaminant exposure. Still, consequences of anthropogenic activities such as contaminant exposure and increasing temperatures are stressors that continue to have deleterious effects on their habitat and health. Transcription profiles of seven health-related gen ...
... Estrogen receptor alpha (ERα) and beta (ERβ) are members of the nuclear receptor superfamily, playing widespread functions in reproductive and non-reproductive tissues. Beside the canonical function of ERs as nuclear receptors, in this review, we summarize our current understanding of extra-nuclear, membrane-initiated functions of ERs with a specific focus on ERα. Over the last decade, in vivo evi ...
... 2‐Monoacylglycerol (2‐MAG) is one of the digestion products of dietary lipids. We recently demonstrated that a 2‐MAG, 2‐arachidonoyl glycerol (2‐AG) potently stimulated cholecystokinin (CCK) secretion via cannabinoid receptor 1 (CB1) in a murine CCK‐producing cell line, STC‐1. CCK plays a crucial role in suppressing postprandial gastric emptying. To examine the effect of 2‐AG on gastric emptying, ...
Petr Holý; Viktor Hlaváč; Pavel Ostašov; Veronika Brynychová; Renata Koževnikovová; Markéta Trnková; Kateřina Kopečková; Soňa Měšťáková; Marcela Mrhalová; Pavel Souček
estrogen receptors; progesterone receptors, etc ; DNA; breast neoplasms; epigenome; gene expression; genetic variation; germ cells; oxysterols; therapeutics; Show all 10 Subjects
Abstract:
... Oxysterols, oxidized derivatives of cholesterol, have been implicated in multiple pathologies, including cancer. In breast cancer, the link is especially strong due to interactions between oxysterols and estrogen receptor activity. Here, we provide the first dedicated study of 113 oxysterol-related genes in breast cancer patients of the luminal subtype, in terms of both their somatic and germline ...
... Norethindrone (NET) is a widely used synthetic progestin, which appears in water environments and threatens aquatic organisms. In this study, marine medaka (Oryzias melastigma) larvae were exposed to 7.6 and 80.1 ng/L NET for 190 days. The effects of NET on growth, sex differentiation, gonad histology and transcriptional expression profiles of hypothalamic‐pituitary‐gonadal (HPG) axis‐related gene ...
olfactory receptors, etc ; epithelial cells; epithelium; Show all 3 Subjects
Abstract:
... Neurons and epithelia are viewed as fundamentally different cell types, yet some sensory neurons exhibit hallmarks of epithelial cells. For example, they use tight junctions to form a diffusion barrier continuous with the skin or other epithelia and they exhibit bona fide apical-basal polarity, with an outward-facing apical surface that is biochemically and functionally distinct from their inward- ...
androgen receptors; aryl hydrocarbon receptors; estrogen receptors, etc ; aquifers; autumn; groundwater; oxidative stress; purification methods; reporter genes; research; river water; rivers; solid phase extraction; stress response; toxicity; water treatment; Show all 16 Subjects
Abstract:
... Artificial infiltration is an established managed aquifer recharge method that is commonly incorporated into drinking water processes. However, groundwater sourced from this type of purification method is prone to contamination with chemical hazards. Such an instance was previously shown at a Swedish DWTP where the river water was contaminated by hazardous chemicals during artificial infiltration. ...
receptors, etc ; plant hormones; planting; stomata; uncertainty; Show all 5 Subjects
Abstract:
... Phytomelatonin is an emerging new plant hormone. The identification of phytomelatonin receptor 1 (PMTR1) has been a turning point for understanding phytomelatonin functions, but many uncertainties remain. Here we highlight how PMTR1-mediated phytomelatonin signaling closes stomata, not just to avoid water loss but also to prevent bacterial invasion at night. ...
... Centella asiatica (CA) and Andrographis paniculata (AP) are widely studied medicinal herbs known for the treatment of many diseases. Studies in the past decades have demonstrated that CA and AP exhibit anticancer effects on various cancer model systems. However, the anti-breast cancer effects of the phytocompounds of CA and AP have not been much explored. This study aimed to screen the possible an ...
... As a frequently detected organophosphate ester in various environmental media, the toxic effects of 2-ethylhexyl diphenyl phosphate (EHDPHP) on aquatic organisms of different sexes remain unclear. In this study, adult zebrafish were exposed to 2.5, 50, 250 µg/L of EHDPHP for 21 days to investigate its sex-dependent reproductive toxicity and related mechanisms. EHDPHP exposure significantly inhibit ...
... Semen quality in men continues to decline in Western countries, but the contours of the issue remain obscure, in relation to contributing chemicals. To obtain more clarity about the chemicals that drive the deterioration of semen quality, we conducted a mixture risk assessment based on European exposures. We included chemicals capable of affecting semen quality after prenatal exposures, among them ...
cytokine receptors, etc ; antigens; cell differentiation; immunomodulation; thymocytes; Show all 5 Subjects
Abstract:
... Innate-like T (iT) cells comprise a population of immunoregulatory T cells whose effector function is imposed during their development in the thymus to provide protective immunity prior to antigen encounter. The molecular mechanism that drives the generation of iT cells remains unclear. Here, we report that the cytokine receptor γc plays a previously unappreciated role for thymic iT cells by contr ...
androgen receptors, etc ; animals; obesity; pathogenesis; pathophysiology; therapeutics; Show all 6 Subjects
Abstract:
... Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitatio ...
... Canine mammary epitheliosis (ME) is a poorly studied dysplasia that may have premalignant potential. In this study, the clinicopathological relevance of ME was prospectively studied in 90 female dogs with mammary tumors (MTs) that underwent radical mastectomy. ME distribution, extent, and coexistence with benign and malignant MTs were evaluated for each case (505 mammary glands). ME was macroscopi ...
Ana Laura Pereira-Suárez; María de la Luz Galván-Ramírez; Laura Rocío Rodríguez-Pérez; Edgar I. López-Pulido; Christian David Hernández-Silva; Inocencia Guadalupe Ramírez-López; Grecia Viridiana Morales Amaya; Luis David Lopez Cabrera; José Francisco Muñoz-Valle; Adrián Ramírez-de-Arellano
estrogen receptors; prolactin receptors, etc ; Toxoplasma gondii; Western blotting; cell growth; inflammation; macrophages; models; monocytes; parasites; parasitology; phosphatidylinositol 3-kinase; pregnancy; tachyzoites; Show all 14 Subjects
Abstract:
... Toxoplasma gondii (T. gondii) is a parasite common in pregnancy. Monocytes and macrophages are a significant immunologic barrier against T. gondii by boosting up inflammation. This outcome is highly regulated by signaling pathways such as MAPK (ERK1/2) and PI3K (AKT), necessary in cell growth and proliferation. It may be associated with the hormonal receptors’ modulation by T. gondii (Estrogen Rec ...