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1. Airway Protection—A Role for Vagal P2RY1 Receptors

Author:
Moayedi, Yalda; Pitman, Michael J.; de Nooij, Joriene C.
Source:
Cell 2020 v.181 no.3 pp. 509-511
ISSN:
0092-8674
Subject:
receptors,   etc   ; foods; larynx;     Show all 3 Subjects
Abstract:
... Recent events bring the importance of respiratory health to the forefront of our collective attention. In this issue of Cell, a new study by Prescott and Umans et al. reveals how a dedicated laryngeal sensory motor reflex circuit protects our airways from aspirated foods or liquids. ...
DOI:
10.1016/j.cell.2020.04.006

2. Synergistic improvement in the performance of insect odorant receptor based biosensors in the presence of Orco

Author:
Khadka, Roshan; Carraher, Colm; Hamiaux, Cyril; Travas-Sejdic, Jadranka; Kralicek, Andrew
Source:
Biosensors & bioelectronics 2020 v.153 pp. 112040
ISSN:
0956-5663
Subject:
odorant receptors,   etc   ; biosensors; insects;     Show all 3 Subjects
Abstract:
... Insect odorant receptors (ORs) are believed to be a complex of an odorant binding subunit, OrX, and an ion channel forming subunit, Orco. In our previous study, we showed that the OrX subunit on its own in liposomes could detect volatile organic compounds (VOCs) ultrasensitively using Electrochemical Impedance Spectroscopy (EIS). In this study, we investigated the effect of the presence of Orco on ...
DOI:
10.1016/j.bios.2020.112040

3. Construction principles to modify responsive performance of fluorescent receptors: From background clearance to signal enhancement

Author:
Zhang, Peng; Zhang, Qian; Zhang, Lianxiao; Zhong, Hua; Ding, Caifeng
Source:
Trends in analytical chemistry 2020 v.123 pp. 115776
ISSN:
0165-9936
Subject:
receptors,   etc   ; chemical equilibrium; fluorescence;     Show all 3 Subjects
Abstract:
... There presents a rapid development for fluorescent sensory systems in recent years, appended with multiple functions, including organelle targeting, near-infrared emission, photothermal property and so forth. These in-depth studies extend the application area undoubtedly, but an excellent responsive behavior still needs a precise control. This Review focuses on the chemical modulation for responsi ...
DOI:
10.1016/j.trac.2019.115776

4. Recruitment and Activation of the ULK1/Atg1 Kinase Complex in Selective Autophagy

Author:
Turco, Eleonora; Fracchiolla, Dorotea; Martens, Sascha
Source:
Journal of molecular biology 2020 v.432 no.1 pp. 123-134
ISSN:
0022-2836
Subject:
receptors,   etc   ; autophagy; enzymes; lysosomes;     Show all 4 Subjects
Abstract:
... Autophagy is a major cellular degradation pathway, which mediates the delivery of cytoplasmic cargo material into lysosomes. This is achieved by the specific sequestration of the cargo within double-membrane vesicles, the autophagosomes, which form de novo around this material. Autophagosome formation requires the action of a conserved set of factors, which act in hierarchical manner. The ULK1/Atg ...
DOI:
10.1016/j.jmb.2019.07.027
PubMed:
31351898
PubMed Central:
PMC6971721

5. Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

Author:
Johansen, Terje; Lamark, Trond
Source:
Journal of molecular biology 2020 v.432 no.1 pp. 80-103
ISSN:
0022-2836
Subject:
receptors,   etc   ; autophagy; mammals; models;     Show all 4 Subjects
Abstract:
... Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors interact with lipidated ATG8 family proteins anchored in the membrane at the concave side of the forming autophagosome. The interaction is mediated by 15- to 20-amino-acid-long sequence motifs called LC3-interacting region (LIR ...
DOI:
10.1016/j.jmb.2019.07.016

6. What Makes a Discovery Successful? The Story of Linda Buck and the Olfactory Receptors

Author:
Barwich, Ann-Sophie
Source:
Cell 2020 v.181 no.4 pp. 749-753
ISSN:
0092-8674
Subject:
G-protein coupled receptors; olfactory receptors,   etc   ; Nobel Prize; smell;     Show all 4 Subjects
Abstract:
... In 1991, Buck and Axel published a landmark study in Cell for work that was awarded the 2004 Nobel Prize. The identification of the olfactory receptors as the largest family of GPCRs catapulted olfaction into mainstream neurobiology. This BenchMark revisits Buck’s experimental innovation and its surprising success at the time. ...
DOI:
10.1016/j.cell.2020.04.040

7. The roles of autotaxin/lysophosphatidic acid in immune regulation and asthma

Author:
Kim, Seung-jae; Moon, Hyung-Geun; Park, Gye Young
Source:
Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158641
ISSN:
1388-1981
Subject:
receptors,   etc   ; asthma; immune response; inflammation;     Show all 4 Subjects
Abstract:
... Lysophosphatidic acid (LPA) species are present in almost all organ systems and play diverse roles through its receptors. Asthma is an airway disease characterized by chronic allergic inflammation where various innate and adaptive immune cells participate in establishing Th2 immune response. Here, we will review the contribution of LPA and its receptors to the functions of immune cells that play a ...
DOI:
10.1016/j.bbalip.2020.158641
PubMed:
32004685
PubMed Central:
PMC7068735

8. Whole blood preservation methods alter chemokine receptor detection in mass cytometry experiments

Author:
Sakkestad, Sunniva Todnem; Skavland, Jørn; Hanevik, Kurt
Source:
Journal of immunological methods 2020 v.476 pp. 112673
ISSN:
0022-1759
Subject:
CCR4 receptor; CCR6 receptor; CXCR3 receptor,   etc   ; CXCR5 receptor; antibodies; buffers; clinical trials; epitopes; leukocytes; permeability; proteomics; stabilizers;     Show all 12 Subjects
Abstract:
... A potential hurdle when applying mass cytometry to the field study setting is the streamlining of sample collection while at the same time protecting the integrity of important cell epitopes. Whole blood preservation kits applying fixation and/or permeabilization agents are increasingly used in clinical trials to preserve leukocytes needed for downstream analysis. We here present a structured over ...
DOI:
10.1016/j.jim.2019.112673

9. Nuclear receptors are the major targets of endocrine disrupting chemicals

Author:
Toporova, Lucia; Balaguer, Patrick
Source:
Molecular and cellular endocrinology 2020 v.502 pp. 110665
ISSN:
0303-7207
Subject:
estrogen receptors; glucocorticoid receptors; mineralocorticoid receptors,   etc   ; adverse effects; androstanes; endocrine system; endocrine-disrupting chemicals; estrogens; humans; ligands; liver; peroxisome proliferator-activated receptor alpha; peroxisome proliferator-activated receptor gamma; pollutants; progesterone receptors; retinoic acid receptors;     Show all 16 Subjects
Abstract:
... Endocrine disrupting chemicals (EDCs) are exogenous substances that are suspected to cause adverse effects in the endocrine system mainly by acting through their interaction with nuclear receptors such as the estrogen receptors α and β (ERα and ERβ), the androgen receptor (AR), the pregnan X receptor (PXR), the peroxisome proliferator activated receptors α and γ (PPARα, PPARγ) and the thyroid rece ...
DOI:
10.1016/j.mce.2019.110665

10. Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition

Author:
Honig, Barry; Shapiro, Lawrence
Source:
Cell 2020 v.181 no.3 pp. 520-535
ISSN:
0092-8674
Subject:
receptors,   etc   ; adhesion; gene editing; neurons; protein structure;     Show all 5 Subjects
Abstract:
... The ability of cells to organize into multicellular structures in precise patterns requires that they “recognize” one another with high specificity. We discuss recent progress in understanding the molecular basis of cell-cell recognition, including unique phenomena associated with neuronal interactions. We describe structures of select adhesion receptor complexes and their assembly into larger int ...
DOI:
10.1016/j.cell.2020.04.010
PubMed:
32359436
PubMed Central:
PMC7233459

11. Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge Verongula rigida

Author:
Kochanowska-Karamyan, Anna J.; Araujo, Hugo C.; Zhang, Xiong; El-Alfy, Abir; Carvalho, Paulo; Avery, Mitchell A.; Holmbo, Stephen D.; Magolan, Jakob; Hamann, Mark T.
Source:
Journal of natural products 2020 v.83 no.4 pp. 1092-1098
ISSN:
1520-6025
Subject:
receptors,   etc   ; Porifera; antidepressants; drug development; pyridines;     Show all 5 Subjects
Abstract:
... The natural product veranamine was isolated from the marine sponge Verongula rigida. It contains a unique heterocyclic scaffold and demonstrates in vivo antidepressant activity and selective affinity for 5HT2B and sigma-1 receptors. The first total synthesis of veranamine is reported. Our scalable synthesis offers veranamine in six steps and 25% yield via an unprecedented vinylogous Pictet–Gams py ...
DOI:
10.1021/acs.jnatprod.9b01107

12. Terminating G-Protein Coupling: Structural Snapshots of GPCR-β-Arrestin Complexes

Author:
Chaturvedi, Madhu; Maharana, Jagannath; Shukla, Arun K.
Source:
Cell 2020 v.180 no.6 pp. 1041-1043
ISSN:
0092-8674
Subject:
G-protein coupled receptors,   etc   ; G-proteins; endocytosis;     Show all 3 Subjects
Abstract:
... β-arrestins (βarrs) play multifaceted roles in the signaling and regulation of G-protein-coupled receptors (GPCRs) including their desensitization and endocytosis. Recently determined cryo-EM structures of two different GPCRs in complex with βarr1 provide the first glimpse of GPCR-βarr engagement and a structural framework to understand their interaction. ...
DOI:
10.1016/j.cell.2020.02.047

13. Systematic Investigation of Molecular Recognition Ability in FET-Based Chemical Sensors Functionalized with a Mixed Self-Assembled Monolayer System

Author:
Minamiki, Tsukuru; Ichikawa, Yuki; Kurita, Ryoji
Source:
ACS applied materials & interfaces 2020 v.12 no.13 pp. 15903-15910
ISSN:
1944-8252
Subject:
receptors,   etc   ; benzoic acids; electrodes; gold; thiols; transistors;     Show all 6 Subjects
Abstract:
... Exploring new strategies for simple and on-demand methods of manipulating the sensing ability of sensor devices functionalized with artificial receptors embedded in a molecular assembly is important to realizing high-throughput on-site sensing systems based on integrated and miniaturized devices such as field-effect transistors (FETs). Although FET-based chemical sensors can be used for rapid, qua ...
DOI:
10.1021/acsami.0c00293

14. Do All Roads Lead to Rome in G-Protein Activation?

Author:
Ghosh, Pradipta; Garcia-Marcos, Mikel
Source:
Trends in biochemical sciences 2020 v.45 no.3 pp. 182-184
ISSN:
0968-0004
Subject:
G-protein coupled receptors,   etc   ; G-proteins; methodology;     Show all 3 Subjects
Abstract:
... High-resolution structural studies on G-protein-coupled receptors (GPCRs) have flourished recently, providing long-sought insights into the dynamic process of guanine nucleotide-binding protein (G-protein) activation. In parallel, analogous studies are starting to shed light on how the same G-proteins are activated by non-GPCR proteins. Can we learn about common themes and variations in G-protein ...
DOI:
10.1016/j.tibs.2019.10.010
PubMed:
31753703
PubMed Central:
PMC7147754

15. Improved structural elucidation of peptide isomers and their receptors using advanced ion mobility-mass spectrometry

Author:
Li, Gongyu; Delafield, Daniel G.; Li, Lingjun
Source:
Trends in analytical chemistry 2020 v.124 pp. 115546
ISSN:
0165-9936
Subject:
receptors,   etc   ; chemical species; instrumentation; neuropeptides; spectroscopy; stereoisomers;     Show all 6 Subjects
Abstract:
... Ion mobility-mass spectrometry (IM-MS) has emerged as a highly important analytical technique for the structural elucidation of a wide range of biomolecules, including neuropeptides, proteins and protein complexes. However, though the inherent value presented by powerful ion mobility techniques has garnered significant interest and spurred on the development of novel and increasingly powerful IM-M ...
DOI:
10.1016/j.trac.2019.05.048

16. The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex

Author:
Lynch, Diane L.; Hurst, Dow P.; Reggio, Patricia H.
Source:
Cell 2020 v.180 no.4 pp. 603-604
ISSN:
0092-8674
Subject:
cannabinoid receptors,   etc   ; G-proteins; cannabinoids; ligands;     Show all 4 Subjects
Abstract:
... In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling. ...
DOI:
10.1016/j.cell.2020.01.034

17. Lactobionamide-based fluorinated detergent for functional and structural stabilization of membrane proteins

Author:
Faugier, Clarisse; Igonet, Sébastien; Cornut, Damien; Besson, Romain; Durand, Grégory; Jawhari, Anass
Source:
Methods 2020
ISSN:
1046-2023
Subject:
purinergic receptors,   etc   ; detergents; drugs; solubilization; surfactants; transporters;     Show all 6 Subjects
Abstract:
... Membrane proteins (MPs) are important drug discovery targets for a wide range of diseases. Conventional detergents such as n-Dodecyl β-D-maltoside have been used largely and efficiently to solubilize MPs with varying degrees of success concerning MPs functionality and stability. Fluorinated surfactants (FSs) have shown a great potential for the stabilization of various MPs. However, so far only a ...
DOI:
10.1016/j.ymeth.2020.02.005

18. Electrochemical Anion Sensing: Supramolecular Approaches

Author:
Hein, Robert; Beer, Paul D.; Davis, Jason J.
Source:
Chemical reviews 2020 v.120 no.3 pp. 1888-1935
ISSN:
1520-6890
Subject:
receptors,   etc   ; anions; electrochemistry; hydrogen; sensory properties; voltammetry;     Show all 6 Subjects
Abstract:
... Anions play a vital role in a broad range of environmental, technological, and physiological processes, making their detection/quantification valuable. Electroanalytical sensors offer much to the selective, sensitive, cheap, portable, and real-time analysis of anion presence where suitable combinations of selective (noncovalent) recognition and transduction can be integrated. Spurred on by signifi ...
DOI:
10.1021/acs.chemrev.9b00624

19. iNR-2L: A two-level sequence-based predictor developed via Chou's 5-steps rule and general PseAAC for identifying nuclear receptors and their families

Author:
Kabir, Muhammad; Ahmad, Saeed; Iqbal, Muhammad; Hayat, Maqsood
Source:
Genomics 2020 v.112 no.1 pp. 276-285
ISSN:
0888-7543
Subject:
receptors,   etc   ; dipeptides; gene expression; models; tripeptides;     Show all 5 Subjects
Abstract:
... Nuclear receptor proteins (NRPs) perform a vital role in regulating gene expression. With the rapidity growth of NRPs in post-genomic era, it is highly recommendable to identify NRPs and their sub-families accurately from their primary sequences. Several conventional methods have been used for discrimination of NRPs and their sub-families, but did not achieve considerable results. In a sequel, a t ...
DOI:
10.1016/j.ygeno.2019.02.006

20. Plant and Animal Innate Immunity Complexes: Fighting Different Enemies with Similar Weapons

Author:
Mermigka, Glykeria; Amprazi, Maria; Mentzelopoulou, Adriani; Amartolou, Argyro; Sarris, Panagiotis F.
Source:
Trends in plant science 2020 v.25 no.1 pp. 80-91
ISSN:
1360-1385
Subject:
receptors,   etc   ; inflammasomes; innate immunity; mammals; plants (botany);     Show all 5 Subjects
Abstract:
... Both animals and plants express intracellular innate immunity receptors known as NLR (NOD-like receptors or nucleotide-binding domain and leucine-rich repeat receptors, respectively). For various mammalian systems, the specific formation of macromolecular structures, such as inflammasomes by activated NLR receptors, has been extensively reported. However, for plant organisms, the formation of such ...
DOI:
10.1016/j.tplants.2019.09.008