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1. Mepanipyrim induces visual developmental toxicity and vision-guided behavioral alteration in zebrafish larvae

Author:
Chao Shen; Yimei Cai; Jialing Li; Chengyong He; Zhenghong Zuo
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 76-88
ISSN:
1001-0742
Subject:
aryl hydrocarbon receptors,   etc   ; Danio rerio; anilinopyrimidine fungicides; developmental toxicity; fruit growing; fungi; genes; light intensity; mepanipyrim; opsin; phototransduction; quantitative polymerase chain reaction; transcriptomics; wavelengths; China;     Show all 15 Subjects
Abstract:
... Mepanipyrim, an anilinopyrimidine fungicide, has been extensively used to prevent fungal diseases in fruit culture. Currently, research on mepanipyrim-induced toxicity in organisms is still very scarce, especially visual developmental toxicity. Here, zebrafish larvae were employed to investigate mepanipyrim-induced visual developmental toxicity. Intense light and monochromatic light stimuli-evoked ...
DOI:
10.1016/j.jes.2021.11.008

2. Examination of aryl hydrocarbon receptor (AhR), estrogenic and anti-androgenic activities, and levels of polyaromatic compounds (PACs) in tire granulates using in vitro bioassays and chemical analysis

Author:
Ulrika Eriksson; Ivan A. Titaley; Magnus Engwall; Maria Larsson
Source:
Chemosphere 2022 v.298 pp. 134362
ISSN:
0045-6535
Subject:
androgen receptors; aryl hydrocarbon receptors; estrogen receptors,   etc   ; bioassays; chemical analysis; heterocyclic compounds; hormone antagonists; toxic substances; toxicity;     Show all 9 Subjects
Abstract:
... Tire granulates recovered from end-of-life tires contain a complex mixture of chemicals, amongst them polyaromatic compounds (PACs), of which many are recognized to be toxic and persistent in the environment. Only a few of these PACs are regularly monitored. In this study a combined approach of chemical analysis and a battery of CALUX® in vitro bioassays was used to determine PAC concentrations an ...
DOI:
10.1016/j.chemosphere.2022.134362

3. Involvement of sirtuins (Sirt1 and Sirt3) and aryl hydrocarbon receptor (AhR) in the effects of triclosan (TCS) on production of neurosteroids in primary mouse cortical neurons cultures

Author:
Konrad A. Szychowski; Bartosz Skóra; Anna K. Wójtowicz
Source:
Pesticide biochemistry and physiology 2022 v.184 pp. 105131
ISSN:
0048-3575
Subject:
androgen receptors; aryl hydrocarbon receptors; estrogen receptors,   etc   ; agonists; antagonists; brain; energy; estradiol; flavonoids; ingredients; mice; nerve tissue; pesticides; physiology; progesterone; sirtuins; testosterone; triclosan;     Show all 18 Subjects
Abstract:
... Epidemiological studies have shown the presence of triclosan (TCS) in the brain due to its widespread use as an antibacterial ingredient. One of the confirmed mechanisms of its action is the interaction with the aryl hydrocarbon receptor (AhR). In nerve cells, sirtuins (Sirt1 and Sirt3) act as cellular sensors detecting energy availability and modulate metabolic processes. Moreover, it has been fo ...
DOI:
10.1016/j.pestbp.2022.105131

4. Relationship between ENaC Regulators and SARS-CoV-2 Virus Receptor (ACE2) Expression in Cultured Adult Human Fungiform (HBO) Taste Cells

Author:
Mehmet Hakan Ozdener; Sunila Mahavadi; Shobha Mummalaneni; Vijay Lyall
Source:
Nutrients 2022 v.14 no.13 pp. -
ISSN:
2072-6643
Subject:
estrogen receptors; taste receptors; virus receptors,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; humans; rodents; smell; taste; transient receptor potential vanilloid channels;     Show all 10 Subjects
Abstract:
... In addition to the α, β, and γ subunits of ENaC, human salt-sensing taste receptor cells (TRCs) also express the δ-subunit. At present, it is not clear if the expression and function of the ENaC δ-subunit in human salt-sensing TRCs is also modulated by the ENaC regulatory hormones and intracellular signaling effectors known to modulate salt responses in rodent TRCs. Here, we used molecular techniq ...
DOI:
10.3390/nu14132703

5. Effects of consumer products chemicals ingredients and their mixtures on the estrogen receptor/androgen receptor transcriptional activation

Author:
Handule Lee; Juyoung Park; Kwangsik Park
Source:
Chemosphere 2022 v.302 pp. 134866
ISSN:
0045-6535
Subject:
androgen receptors; estrogen receptors,   etc   ; androgens; estrogens; logit analysis; phthalates; prediction; risk assessment; transcriptional activation;     Show all 9 Subjects
Abstract:
... Unlike the environmental pollutants or industrial chemicals, the chemicals in consumer products may pose higher levels of risks, depending on how the chemicals are used in the products and how humans interact with the products. Recently, endocrine disrupting chemicals in cosmetics, personal care products, cleaners, sunscreens, and vinyl products were analytically quantified and many active chemica ...
DOI:
10.1016/j.chemosphere.2022.134866

6. Relationships between gene transcription and contaminant concentrations in Baltic ringed seals: A comparison between tissue matrices

Author:
Joy Ometere Boyi; Iben Stokholm; Miriam Hillmann; Jens Søndergaard; Sara Persson; Cynthia A. de Wit; Ursula Siebert; Lehnert Kristina
Source:
Aquatic toxicology 2022 v.242 pp. 106035
ISSN:
0166-445X
Subject:
aryl hydrocarbon receptors; estrogen receptors; retinoic acid receptors,   etc   ; biomarkers; blood; blubber; gene expression; habitats; heat-shock protein 70; lipids; liver; mercury; messenger RNA; metabolism; muscles; thyroid hormone receptors; toxicology; transcription (genetics); wildlife; xenobiotics; Baltic Sea;     Show all 21 Subjects
Abstract:
... Ringed seals (Pusa hispida) are slowly recovering in the eastern and northern parts of the Baltic Sea after years of hunting pressure and contaminant exposure. Still, consequences of anthropogenic activities such as contaminant exposure and increasing temperatures are stressors that continue to have deleterious effects on their habitat and health. Transcription profiles of seven health-related gen ...
DOI:
10.1016/j.aquatox.2021.106035

7. Segregation of nuclear and membrane-initiated actions of estrogen receptor using genetically modified animals and pharmacological tools

Author:
Marine Adlanmerini; Coralie Fontaine; Pierre Gourdy; Jean-François Arnal; Françoise Lenfant
Source:
Molecular and cellular endocrinology 2022 v.539 pp. 111467
ISSN:
0303-7207
Subject:
estrogen receptors,   etc   ; mice; physiology;     Show all 3 Subjects
Abstract:
... Estrogen receptor alpha (ERα) and beta (ERβ) are members of the nuclear receptor superfamily, playing widespread functions in reproductive and non-reproductive tissues. Beside the canonical function of ERs as nuclear receptors, in this review, we summarize our current understanding of extra-nuclear, membrane-initiated functions of ERs with a specific focus on ERα. Over the last decade, in vivo evi ...
DOI:
10.1016/j.mce.2021.111467

8. 2‐Arachidonoyl glycerol suppresses gastric emptying via the cannabinoid receptor 1‐cholecystokinin signaling pathway in mice

Author:
Keita Ochiai; Rina Hirooka; Masayoshi Sakaino; Shigeo Takeuchi; Tohru Hira
Source:
Lipids 2022 v.57 no.3 pp. 173-181
ISSN:
0024-4201
Subject:
cannabinoid receptors; cholecystokinin receptors,   etc   ; absorption; acetaminophen; antagonists; cell lines; cholecystokinin; glycerol; intraperitoneal injection; mice; phenolsulfonphthalein; secretion;     Show all 12 Subjects
Abstract:
... 2‐Monoacylglycerol (2‐MAG) is one of the digestion products of dietary lipids. We recently demonstrated that a 2‐MAG, 2‐arachidonoyl glycerol (2‐AG) potently stimulated cholecystokinin (CCK) secretion via cannabinoid receptor 1 (CB1) in a murine CCK‐producing cell line, STC‐1. CCK plays a crucial role in suppressing postprandial gastric emptying. To examine the effect of 2‐AG on gastric emptying, ...
DOI:
10.1002/lipd.12341

9. Germline and somatic genetic variability of oxysterol-related genes in breast cancer patients with early disease of the luminal subtype

Author:
Petr Holý; Viktor Hlaváč; Pavel Ostašov; Veronika Brynychová; Renata Koževnikovová; Markéta Trnková; Kateřina Kopečková; Soňa Měšťáková; Marcela Mrhalová; Pavel Souček
Source:
Biochimie 2022 v.199 pp. 158-169
ISSN:
0300-9084
Subject:
estrogen receptors; progesterone receptors,   etc   ; DNA; breast neoplasms; epigenome; gene expression; genetic variation; germ cells; oxysterols; therapeutics;     Show all 10 Subjects
Abstract:
... Oxysterols, oxidized derivatives of cholesterol, have been implicated in multiple pathologies, including cancer. In breast cancer, the link is especially strong due to interactions between oxysterols and estrogen receptor activity. Here, we provide the first dedicated study of 113 oxysterol-related genes in breast cancer patients of the luminal subtype, in terms of both their somatic and germline ...
DOI:
10.1016/j.biochi.2022.04.015

10. Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma)

Author:
Zhongdian Dong; Yuebi Chen; Xueyou Li; Ning Zhang; Yusong Guo; Yan‐Qiu Liang; Zhongduo Wang
Source:
Environmental toxicology 2022 v.37 no.5 pp. 1211-1221
ISSN:
1520-4081
Subject:
estrogen receptors; glucocorticoid receptors; progesterone receptors,   etc   ; Oryzias melastigma; aromatase; brain; ecotoxicology; gene expression; histology; liver; luteinizing hormone; sexual development; spermatozoa; steroidogenic acute regulatory protein; transcription (genetics); vitellogenin;     Show all 16 Subjects
Abstract:
... Norethindrone (NET) is a widely used synthetic progestin, which appears in water environments and threatens aquatic organisms. In this study, marine medaka (Oryzias melastigma) larvae were exposed to 7.6 and 80.1 ng/L NET for 190 days. The effects of NET on growth, sex differentiation, gonad histology and transcriptional expression profiles of hypothalamic‐pituitary‐gonadal (HPG) axis‐related gene ...
DOI:
10.1002/tox.23477

11. When is a neuron like an epithelial cell

Author:
Maxwell G. Heiman
Source:
Developmental biology 2022 v.489 pp. 161-164
ISSN:
0012-1606
Subject:
olfactory receptors,   etc   ; epithelial cells; epithelium;     Show all 3 Subjects
Abstract:
... Neurons and epithelia are viewed as fundamentally different cell types, yet some sensory neurons exhibit hallmarks of epithelial cells. For example, they use tight junctions to form a diffusion barrier continuous with the skin or other epithelia and they exhibit bona fide apical-basal polarity, with an outward-facing apical surface that is biochemically and functionally distinct from their inward- ...
DOI:
10.1016/j.ydbio.2022.06.012

12. Artificial infiltration in drinking water production: Addressing chemical hazards using effect-based methods

Author:
Maria Yu; Shreya Mapuskar; Elin Lavonen; Agneta Oskarsson; Philip McCleaf; Johan Lundqvist
Source:
Water research 2022 v.221 pp. 118776
ISSN:
0043-1354
Subject:
androgen receptors; aryl hydrocarbon receptors; estrogen receptors,   etc   ; aquifers; autumn; groundwater; oxidative stress; purification methods; reporter genes; research; river water; rivers; solid phase extraction; stress response; toxicity; water treatment;     Show all 16 Subjects
Abstract:
... Artificial infiltration is an established managed aquifer recharge method that is commonly incorporated into drinking water processes. However, groundwater sourced from this type of purification method is prone to contamination with chemical hazards. Such an instance was previously shown at a Swedish DWTP where the river water was contaminated by hazardous chemicals during artificial infiltration. ...
DOI:
10.1016/j.watres.2022.118776

13. Phytomelatonin prevents bacterial invasion during nighttime

Author:
Xiaomin Li; Zed Rengel; Qi Chen
Source:
Trends in plant science 2022 v.27 no.4 pp. 331-334
ISSN:
1360-1385
Subject:
receptors,   etc   ; plant hormones; planting; stomata; uncertainty;     Show all 5 Subjects
Abstract:
... Phytomelatonin is an emerging new plant hormone. The identification of phytomelatonin receptor 1 (PMTR1) has been a turning point for understanding phytomelatonin functions, but many uncertainties remain. Here we highlight how PMTR1-mediated phytomelatonin signaling closes stomata, not just to avoid water loss but also to prevent bacterial invasion at night. ...
DOI:
10.1016/j.tplants.2021.12.008

14. ER and PGR targeting ability of phytocompounds derived from Centella asiatica and Andrographis paniculata: An in-silico approach

Author:
Geeta Swargiary; Shalini Mani
Source:
Journal of herbal medicine 2022 v.32 pp. 100541
ISSN:
2210-8033
Subject:
estrogen receptors; progesterone receptors,   etc   ; Andrographis paniculata; Centella asiatica; andrographolide; apigenin; breasts; computer simulation; energy; herbal medicines; kaempferol; ligands;     Show all 12 Subjects
Abstract:
... Centella asiatica (CA) and Andrographis paniculata (AP) are widely studied medicinal herbs known for the treatment of many diseases. Studies in the past decades have demonstrated that CA and AP exhibit anticancer effects on various cancer model systems. However, the anti-breast cancer effects of the phytocompounds of CA and AP have not been much explored. This study aimed to screen the possible an ...
DOI:
10.1016/j.hermed.2022.100541

15. Insights into the sex-dependent reproductive toxicity of 2-ethylhexyl diphenyl phosphate on zebrafish (Danio rerio)

Author:
Rongyan Yang; Xiao Wang; Jingwen Wang; Pengyu Chen; Qing Liu; Wenjue Zhong; Lingyan Zhu
Source:
Environment international 2022 v.158 pp. 106928
ISSN:
0160-4120
Subject:
androgen receptors; estrogen receptors,   etc   ; Danio rerio; adults; biphenyl; brain; environment; organophosphorus compounds; phosphates; progeny; reproductive toxicology; testosterone; toxicity; vitellogenin;     Show all 14 Subjects
Abstract:
... As a frequently detected organophosphate ester in various environmental media, the toxic effects of 2-ethylhexyl diphenyl phosphate (EHDPHP) on aquatic organisms of different sexes remain unclear. In this study, adult zebrafish were exposed to 2.5, 50, 250 µg/L of EHDPHP for 21 days to investigate its sex-dependent reproductive toxicity and related mechanisms. EHDPHP exposure significantly inhibit ...
DOI:
10.1016/j.envint.2021.106928

16. Combined exposures to bisphenols, polychlorinated dioxins, paracetamol, and phthalates as drivers of deteriorating semen quality

Author:
Andreas Kortenkamp; Martin Scholze; Sibylle Ermler; Lærke Priskorn; Niels Jørgensen; Anna-Maria Andersson; Hanne Frederiksen
Source:
Environment international 2022 v.165 pp. 107322
ISSN:
0160-4120
Subject:
androgen receptors; aryl hydrocarbon receptors,   etc   ; acetaminophen; bisphenol A; environment; environmental monitoring; phthalates; prostaglandins; risk; risk assessment; semen quality; testosterone; Europe;     Show all 13 Subjects
Abstract:
... Semen quality in men continues to decline in Western countries, but the contours of the issue remain obscure, in relation to contributing chemicals. To obtain more clarity about the chemicals that drive the deterioration of semen quality, we conducted a mixture risk assessment based on European exposures. We included chemicals capable of affecting semen quality after prenatal exposures, among them ...
DOI:
10.1016/j.envint.2022.107322

17. Protein abundance of the cytokine receptor γc controls the thymic generation of innate-like T cells

Author:
Joo-Young Park; Hee Yeun Won; Devon T. DiPalma; Changwan Hong; Jung-Hyun Park
Source:
Cellular and molecular life sciences 2022 v.79 no.1 pp. 17
ISSN:
1420-682X
Subject:
cytokine receptors,   etc   ; antigens; cell differentiation; immunomodulation; thymocytes;     Show all 5 Subjects
Abstract:
... Innate-like T (iT) cells comprise a population of immunoregulatory T cells whose effector function is imposed during their development in the thymus to provide protective immunity prior to antigen encounter. The molecular mechanism that drives the generation of iT cells remains unclear. Here, we report that the cytokine receptor γc plays a previously unappreciated role for thymic iT cells by contr ...
DOI:
10.1007/s00018-021-04067-3

18. The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

Author:
Varun S. Venkatesh; Mathis Grossmann; Jeffrey D. Zajac; Rachel A. Davey
Source:
Obesity reviews 2022 v.23 no.6 pp. e13429
ISSN:
1467-7881
Subject:
androgen receptors,   etc   ; animals; obesity; pathogenesis; pathophysiology; therapeutics;     Show all 6 Subjects
Abstract:
... Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitatio ...
DOI:
10.1111/obr.13429

19. Epitheliosis is a histopathological finding associated with malignancy and poor prognosis in dogs with mammary tumors

Author:
Guillermo Valdivia; Ángela Alonso-Diez; Daniel Alonso-Miguel; María Suárez; Paloma García; Gustavo Ortiz-Díez; Maria Dolores Pérez-Alenza; Laura Peña
Source:
Veterinary pathology 2022 v.59 no.5 pp. 747-758
ISSN:
1544-2217
Subject:
estrogen receptors; progesterone receptors,   etc   ; animal pathology; biopsy; dogs; erbB-2 receptor; females; histopathology; humans; hyperplasia; immunohistochemistry; lymph nodes; metastasis; prognosis; vimentin;     Show all 15 Subjects
Abstract:
... Canine mammary epitheliosis (ME) is a poorly studied dysplasia that may have premalignant potential. In this study, the clinicopathological relevance of ME was prospectively studied in 90 female dogs with mammary tumors (MTs) that underwent radical mastectomy. ME distribution, extent, and coexistence with benign and malignant MTs were evaluated for each case (505 mammary glands). ME was macroscopi ...
DOI:
10.1177/03009858221092013

20. 17β-estradiol modulates the expression of hormonal receptors on THP-1 T. gondii-infected macrophages and monocytes in an AKT and ERK-dependent manner

Author:
Ana Laura Pereira-Suárez; María de la Luz Galván-Ramírez; Laura Rocío Rodríguez-Pérez; Edgar I. López-Pulido; Christian David Hernández-Silva; Inocencia Guadalupe Ramírez-López; Grecia Viridiana Morales Amaya; Luis David Lopez Cabrera; José Francisco Muñoz-Valle; Adrián Ramírez-de-Arellano
Source:
Molecular and biochemical parasitology 2022 v.247 pp. 111433
ISSN:
0166-6851
Subject:
estrogen receptors; prolactin receptors,   etc   ; Toxoplasma gondii; Western blotting; cell growth; inflammation; macrophages; models; monocytes; parasites; parasitology; phosphatidylinositol 3-kinase; pregnancy; tachyzoites;     Show all 14 Subjects
Abstract:
... Toxoplasma gondii (T. gondii) is a parasite common in pregnancy. Monocytes and macrophages are a significant immunologic barrier against T. gondii by boosting up inflammation. This outcome is highly regulated by signaling pathways such as MAPK (ERK1/2) and PI3K (AKT), necessary in cell growth and proliferation. It may be associated with the hormonal receptors’ modulation by T. gondii (Estrogen Rec ...
DOI:
10.1016/j.molbiopara.2021.111433