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1. A bacterially expressed triple-type chimeric vaccine against human papillomavirus types 51, 69, and 26

Author:
Miao Yu; Xin Chi; Shiwen Huang; Zhiping Wang; Jie Chen; Ciying Qian; Feng Han; Lin Cao; Jinjin Li; Hui Sun; Lizhi Zhou; Tingting Li; Yingbin Wang; Qingbing Zheng; Hai Yu; Jun Zhang; Ningshao Xia; Shaowei Li; Ying Gu
Source:
Vaccine 2022 v.40 no.42 pp. 6141-6152
ISSN:
0264-410X
Subject:
recombinant vaccines,   etc   ; Escherichia coli; Papillomaviridae; carcinogenicity; chronic diseases; epitopes; humans; immunogenicity; uterine cervical neoplasms; vaccine development;     Show all 10 Subjects
Abstract:
... Persistent infection of high-risk human papillomavirus (HPV) is a leading cause of some cancers, including cervical cancer. However, with over 20 carcinogenic HPV types, it is difficult to design a multivalent vaccine that can offer complete protection. Here, we describe the design and optimization of a HPV51/69/26 triple-type chimeric virus-like particle (VLP) for vaccine development. Using E. co ...
DOI:
10.1016/j.vaccine.2022.09.010

2. Protective immunity induced with a DNA vaccine encoding B- and T-cells multi-epitope SAG1, ROP16, MIC4, GRA12, M2AP, and multi-epitope ROP8 against acute and chronic toxoplasmosis in BALB/c mice

Author:
Ali Dalir Ghaffari; Abdolhossein Dalimi; Fatemeh Ghaffarifar; Majid Pirestani
Source:
Experimental parasitology 2022 pp. 108385
ISSN:
0014-4894
Subject:
recombinant vaccines,   etc   ; T-lymphocytes; antibodies; brain; cytokines; immune response; immunoglobulin G; lymphocyte proliferation; parasitology; people; plasmids; toxoplasmosis; vaccination;     Show all 13 Subjects
Abstract:
... T. gondii infection is characterized by a high global prevalence. Nearly, 16–40% of people have been infected by T. gondii. Although T. gondii often causes subclinical infection, it may cause severe complications in newborns with congenital infection and immunocompromised individuals. Constant attempts of scientists have made valuable findings in the development of T. gondii candidate vaccines. Ho ...
DOI:
10.1016/j.exppara.2022.108385

3. Recent progress and advances towards developing enterovirus 71 vaccines for effective protection against human hand, foot and mouth disease (HFMD)

Author:
Aliyu Maje Bello; Yaowaluck Maprang Roshorm
Source:
Biologicals 2022 v.79 pp. 1-9
ISSN:
1045-1056
Subject:
recombinant vaccines,   etc   ; Enterovirus A; financial economics; foot-and-mouth disease; humans; pathogens; public health; recombinant DNA; vaccination; vaccine development;     Show all 10 Subjects
Abstract:
... The main pathogen causing severe and neurotrophic hand, foot and mouth disease (HFMD) is enterovirus A71 (EV71). EV71 infection is among the major cause of serious public health burden and economic loss especially in the Asia-pacific region. Yet, no specific anti-viral treatment against this life-threatening infection is currently available. Thus, the best way to control EV71 infection is by vacci ...
DOI:
10.1016/j.biologicals.2022.08.007

4. Differences in the protection elicited by a recombinant Teladorsagia circumcincta vaccine in weaned lambs of two Canarian sheep breeds

Author:
Tara Pérez-Hernández; Yolanda Corripio-Miyar; Julia N. Hernández; Cynthia Machín; Yania Paz-Sánchez; Adam D. Hayward; Harry W. Wright; Daniel R.G. Price; Jacqueline B. Matthews; Tom N. McNeilly; Alasdair J. Nisbet; Jorge F. González
Source:
Veterinary parasitology 2022 v.306 pp. 109722
ISSN:
0304-4017
Subject:
recombinant vaccines,   etc   ; Teladorsagia circumcincta; anthelmintics; females; gastrointestinal nematodes; genetic resistance; immunity; larvae; prototypes; synergism; vaccination; veterinary parasitology; weight gain;     Show all 13 Subjects
Abstract:
... Gastrointestinal nematode (GIN) infections are a serious drawback on small ruminant production. Since anthelmintic resistance has extended, optimisation of alternative non-chemical control strategies has attracted interest. Recently, a prototype recombinant vaccine protected immunologically mature sheep from Texel-cross and Canaria Sheep breeds against Teladorsagia circumcincta. The level of prote ...
DOI:
10.1016/j.vetpar.2022.109722

5. Development of a recombinant vaccine containing a spike S1-Fc fusion protein induced protection against MERS-CoV in human DPP4 knockin transgenic mice

Author:
Bo-Kyoung Jung; YongHee An; Jung-Eun Park; Kyung-Soo Chang; Hyun Jang
Source:
Journal of virological methods 2022 v.299 pp. 114347
ISSN:
0166-0934
Subject:
recombinant vaccines,   etc   ; Coronavirus infections; Cricetulus griseus; Middle East respiratory syndrome coronavirus; humans; humoral immunity; immunogenicity; immunoglobulin G; secretion; therapeutics; virulent strains;     Show all 11 Subjects
Abstract:
... The Middle East respiratory syndrome coronavirus (MERS-CoV), belonging to the family Coronaviridae and genus Betacoronavirus, has been recognized as a highly pathogenic virus. Due to the lack of therapeutic or preventive agents against MERS-CoV, developing an effective vaccine is essential for preventing a viral outbreak. To address this, we developed a recombinant S1 subunit of MERS-CoV spike pro ...
DOI:
10.1016/j.jviromet.2021.114347

6. Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates

Author:
Jewell N. Walters; Blake Schouest; Ami Patel; Emma L. Reuschel; Katherine Schultheis; Elizabeth Parzych; Igor Maricic; Ebony N. Gary; Mansi Purwar; Viviane M. Andrade; Arthur Doan; Dustin Elwood; Zeena Eblimit; Brian Nguyen; Drew Frase; Faraz I. Zaidi; Abhijeet Kulkarni; Alison Generotti; J Joseph Kim; Laurent M. Humeau; Stephanie J. Ramos; Trevor R.F. Smith; David B. Weiner; Kate E. Broderick
Source:
Vaccine 2022 v.40 no.21 pp. 2960-2969
ISSN:
0264-410X
Subject:
recombinant vaccines,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibodies; clinical examination; durability; immune evasion; immunogenicity; landscapes; pandemic; vaccination;     Show all 11 Subjects
Abstract:
... The enhanced transmissibility and immune evasion associated with emerging SARS-CoV-2 variants demands the development of next-generation vaccines capable of inducing superior protection amid a shifting pandemic landscape. Since a portion of the global population harbors some level of immunity from vaccines based on the original Wuhan-Hu-1 SARS-CoV-2 sequence or natural infection, an important ques ...
DOI:
10.1016/j.vaccine.2022.03.060

7. A multipathogen DNA vaccine elicits protective immune responses against two class A bioterrorism agents, anthrax and botulism

Author:
Na Young Kim; Won Rak Son; Min Hoon Lee; Hong Seok Choi; Jun Young Choi; Young Jo Song; Chi Ho Yu; Dong Hyun Song; Gyeung Haeng Hur; Seong Tae Jeong; Sung Youl Hong; Young Kee Shin; Sungho Shin
Source:
Applied microbiology and biotechnology 2022 v.106 no.4 pp. 1531-1542
ISSN:
0175-7598
Subject:
recombinant vaccines,   etc   ; Bacillus anthracis; Clostridium botulinum; anthrax; biotechnology; bioterrorism; blood serum; botulinum toxin; botulism; disease outbreaks; genes; microbiology; public health; vaccination; vaccine development;     Show all 15 Subjects
Abstract:
... The potential use of biological agents has become a major public health concern worldwide. According to the CDC classification, Bacillus anthracis and Clostridium botulinum, the bacterial pathogens that cause anthrax and botulism, respectively, are considered to be the most dangerous potential biological agents. Currently, there is no licensed vaccine that is well suited for mass immunization in t ...
DOI:
10.1007/s00253-022-11812-6

8. Evaluation of a Novel DNA Vaccine Double Encoding Somatostatin and Cortistatin for Promoting the Growth of Mice

Author:
Xuan Luo; Zhuoxin Zu; Hasan Riaz; Xingang Dan; Xue Yu; Shuanghang Liu; Aizhen Guo; Yilin Wen; Aixin Liang; Liguo Yang
Source:
Animals 2022 v.12 no.12 pp. -
ISSN:
2076-2615
Subject:
recombinant vaccines,   etc   ; animal growth; antibodies; body weight changes; economics; fluorescence; fluorescence microscopy; hepatitis B antigens; hormone secretion; immunization; livestock; plasmids; somatostatin; transfection; weight gain;     Show all 15 Subjects
Abstract:
... Animal growth traits are directly linked with the economics of livestock species. A somatostatin DNA vaccine has been developed to improve the growth of animals. However, the growth-promoting effect is still unsatisfying. The current study aimed to evaluate the effect of a novel eukaryotic dual expression vaccine known as pIRES-S/CST14-S/2SS, which encodes the genes obtained by fusing somatostatin ...
DOI:
10.3390/ani12121490

9. Immunogenicity of a xenogeneic multi-epitope HER2+ breast cancer DNA vaccine targeting the dendritic cell restricted antigen-uptake receptor DEC205

Author:
Aytül Gül; Mert Döşkaya; Hüseyin Can; Muhammet Karakavuk; Müge Anıl-İnevi; Pelin Sağlam-Metiner; Esra Atalay-Şahar; Aysu Değirmenci-Döşkaya; Osman Zekioğlu; Adnan Yüksel Gürüz; Sultan Gülce-Iz; Levent Yeniay
Source:
Vaccine 2022 v.40 no.16 pp. 2409-2419
ISSN:
0264-410X
Subject:
recombinant vaccines,   etc   ; B-lymphocytes; DNA; antibodies; breast neoplasms; computer simulation; dendritic cells; epitopes; humans; immune response; immunogenicity; immunoglobulin G; mice; rats; survival rate; therapeutics;     Show all 16 Subjects
Abstract:
... Breast cancer was ranked first in global cancer incidence in 2020, and HER2 overexpression in breast cancer accounts for 20–30% of breast cancer patients. Current therapeutic strategies increase the survival rate, but resistance to them occurs frequently, and there is an urgent need to develop novel treatments such as DNA vaccines which can induce a specific and long-lasting immune response agains ...
DOI:
10.1016/j.vaccine.2022.03.014

10. Protective immunity by DNA vaccine against Micropterus salmoides rhabdovirus

Author:
Bin Yang; Zi‐Rao Guo; Zhao Zhao; Tao Wang; Fei Yang; Fei Ling; Bin Zhu; Gao‐Xue Wang
Source:
Journal of fish diseases 2022 v.45 no.10 pp. 1429-1437
ISSN:
0140-7775
Subject:
recombinant vaccines,   etc   ; Micropterus salmoides; Rhabdoviridae; acid phosphatase; alkaline phosphatase; antibodies; blood serum; fish; genes; glycoproteins; immunity; industry; interleukin-12; interleukin-8; juveniles; mortality; plasmids;     Show all 17 Subjects
Abstract:
... Micropterus salmoides rhabdovirus (MSRV) is one of the common pathogens in the largemouth bass industry, which can cause lethal diseases in juvenile fish and enormous economic losses. To establish effective means to prevent MSRV infection, the pcDNA3.1‐G plasmid containing the MSRV glycoprotein gene was successfully constructed and intramuscularly injected into the largemouth bass to evaluate the ...
DOI:
10.1111/jfd.13672

11. Designing of a Chimeric Vaccine Using EIS (Rv2416c) Protein Against Mycobacterium tuberculosis H37Rv: an Immunoinformatics Approach

Author:
R. Logesh; V. Lavanya; Shazia Jamal; Neesar Ahmed
Source:
Applied biochemistry and biotechnology 2022 v.194 no.1 pp. 187-214
ISSN:
0273-2289
Subject:
recombinant vaccines,   etc   ; B-lymphocytes; Mycobacterium tuberculosis; T-lymphocytes; Toll-like receptor 4; alleles; allergenicity; biotechnology; cytotoxicity; epitopes; immune response; immunogenicity; immunoinformatics; pathogenesis; pathogens; tuberculosis;     Show all 16 Subjects
Abstract:
... Mycobacterium tuberculosis (Mtb) is a respiratory pathogen that causes tuberculosis (TB). There are a large number of proteins that are involved in the pathogenesis of TB. Stimulating the immune response against TB is very important to clear the pathogens from host. In the present study, an immunoinformatics conduit is used for designing an epitope based chimeric vaccine against TB. Enhanced intra ...
DOI:
10.1007/s12010-021-03760-0

12. Engineered flavivirus vaccines control induction of crossreactive infection-enhancing and -neutralizing antibodies

Author:
Atsushi Yamanaka; Pimploy Rattanaamnuaychai; Mami Matsuda; Ryosuke Suzuki; Yoshiharu Matsuura; Masashi Tatsumi; Eiji Konishi
Source:
Vaccine 2022 v.40 no.42 pp. 6004-6011
ISSN:
0264-410X
Subject:
recombinant vaccines,   etc   ; Japanese encephalitis virus; West Nile virus; Zika virus; amino acid substitution; antibodies; antigens; cross immunity; dengue; disease severity; geographical distribution; humans; risk;     Show all 13 Subjects
Abstract:
... Flaviviruses are important human pathogens because of their global distribution and disease severity. The high structural similarity among flaviviruses induces cross-immunity, with individual flaviviruses exhibiting crossreactive infection-enhancing and/or -neutralizing activities against other flaviviruses. Unlike neutralizing antibodies, enhancing antibodies may increase the risk of disease seve ...
DOI:
10.1016/j.vaccine.2022.09.012

13. Effects of a DNA and multivalent oil-adjuvanted vaccines against pancreas disease in Atlantic salmon (Salmo salar) challenged with salmonid alphavirus subtype 3

Author:
Ragnar Thorarinsson; Jeffrey C. Wolf; Makoto Inami; Hilde Sindre; Eystein Skjerve; Øystein Evensen; Espen Rimstad
Source:
Fish and shellfish immunology reports 2022 v.3 pp. 100063
ISSN:
2667-0119
Subject:
recombinant vaccines,   etc   ; Alphavirus; DNA; Salmo salar; economic impact; fish; fish health; heart; mortality; necrosis; pancreas; pancreas disease; seawater; shellfish; vaccination; viremia; viruses; weight gain; Norway;     Show all 19 Subjects
Abstract:
... Salmonid alphavirus (SAV) causes pancreas disease (PD) in Atlantic salmon (Salmo salar). In seawater-farmed salmonids in the southern part of Norway SAV subtype 3 (SAV3) is dominating. PD continues to cause significant economic and fish health concerns in this region despite years of extensive use of oil-adjuvanted vaccines (OAVs) containing inactivated whole virus (IWV) antigens. In the current s ...
DOI:
10.1016/j.fsirep.2022.100063

14. Reverse vaccinology approach for multi-epitope centered vaccine design against delta variant of the SARS-CoV-2

Author:
Khurshid Jalal; Kanwal Khan; Zarrin Basharat; Muhammad Naseer Abbas; Reaz Uddin; Fawad Ali; Saeed Ahmad Khan; Syed Shams ul Hassan
Source:
Environmental science and pollution research 2022 v.29 no.40 pp. 60035-60053
ISSN:
0944-1344
Subject:
recombinant vaccines,   etc   ; B-lymphocytes; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; computer simulation; epitopes; immune response; models; pollution; research; vaccine development; China; India;     Show all 13 Subjects
Abstract:
... The ongoing COVID-19 outbreak, initially identified in Wuhan, China, has impacted people all over the globe and new variants of concern continue to threaten hundreds of thousands of people. The delta variant (first reported in India) is currently classified as one of the most contagious variants of SARS-CoV-2. It is estimated that the transmission rate of delta variant is 225% times faster than th ...
DOI:
10.1007/s11356-022-19979-1

15. An integrated in silico based subtractive genomics and reverse vaccinology approach for the identification of novel vaccine candidate and chimeric vaccine against XDR Salmonella typhi H58

Author:
Kanwal Khan; Khurshid Jalal; Reaz Uddin
Source:
Genomics 2022 v.114 no.2 pp. 110301
ISSN:
0888-7543
Subject:
recombinant vaccines,   etc   ; Salmonella Typhi; computer simulation; drug resistance; epitopes; fever; genomics; human population; immune response; lipoproteins; nucleotide sequences; peptides; prioritization; proteome; typhoid fever; vaccination; vaccine development; virulence;     Show all 18 Subjects
Abstract:
... Salmonella typhi is notorious for causing enteric fever which is also known as typhoid fever. It emerged as an extreme drug resistant strain that requires urgent attention to prevent its global spread. Statistically, about 11–17 million typhoid illnesses are reported worldwide annually. The only alternative approach for the control of this illness is proper vaccination. However, available typhoid ...
DOI:
10.1016/j.ygeno.2022.110301

16. Characterization of Immune Response Diversity in Rodents Vaccinated with a Vesicular Stomatitis Virus Vectored COVID-19 Vaccine

Author:
Shen Wang; Cheng Zhang; Bo Liang; Weiqi Wang; Na Feng; Yongkun Zhao; Tiecheng Wang; Zhendong Guo; Feihu Yan; Songtao Yang; Xianzhu Xia
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
recombinant vaccines,   etc   ; COVID-19 infection; Mesocricetus auratus; Severe acute respiratory syndrome coronavirus 2; Vesiculovirus; animal models; cell-mediated immunity; humans; humoral immunity; immune response; immunization; immunogenicity; public health;     Show all 13 Subjects
Abstract:
... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as the prime challenge facing public health safety since 2019. Correspondingly, coronavirus disease 2019 (COVID-19) vaccines have been developed and administered worldwide, varying in design strategies, delivery routes, immunogenicity and protective efficacy. Here, a replication-competent vesicular stomatitis virus (VSV) vect ...
DOI:
10.3390/v14061127

17. A promiscuous T cell epitope-based HIV vaccine providing redundant population coverage of the HLA class II elicits broad, polyfunctional T cell responses in nonhuman primates

Author:
Susan Pereira Ribeiro; Vania Gomes De Moura Mattaraia; Rafael Ribeiro Almeida; Elizabeth Juliana Ghiuro Valentine; Natiely Silva Sales; Luís Carlos S. Ferreira; Luiz Carlos Sa-Rocha; Lucas Cauê Jacintho; Vinicius Canato Santana; John Sidney; Alessandro Sette; Daniela Santoro Rosa; Jorge Kalil; Edecio Cunha-Neto
Source:
Vaccine 2022 v.40 no.2 pp. 239-246
ISSN:
0264-410X
Subject:
recombinant vaccines,   etc   ; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; COVID-19 infection; HIV infections; cell-mediated immunity; electroporation; epitopes; genetically modified organisms; human population; humans; immunization; peptides;     Show all 13 Subjects
Abstract:
... Over the last few decades, several emerging or reemerging viral diseases with no readily available vaccines have ravaged the world. A platform to fastly generate vaccines inducing potent and durable neutralizing antibody and T cell responses is sorely needed. Bioinformatically identified epitope-based vaccines can focus on immunodominant T cell epitopes and induce more potent immune responses than ...
DOI:
10.1016/j.vaccine.2021.11.076

18. Enhanced synergistic antitumor effect of a DNA vaccine with anticancer cytokine, MDA-7/IL-24, and immune checkpoint blockade

Author:
Seyed Mohammad Miri; Behzad Pourhossein; Seyed Younes Hosseini; Mohsen Keshavarz; Shohreh Shahmahmoodi; Mohammad Reza Zolfaghari; Seyed Reza Mohebbi; Ali Gorji; Amir Ghaemi
Source:
Virology journal 2022 v.19 no.1 pp. 106
ISSN:
1743-422X
Subject:
recombinant vaccines,   etc   ; DNA; Papillomaviridae; adjuvants; antineoplastic activity; apoptosis; caspase-9; cytotoxicity; humans; immunogenicity; immunohistochemistry; immunosuppression; interleukin-10; interleukin-4; mice; remission; secretion; spleen; uterine cervical neoplasms; vaccination; virology;     Show all 21 Subjects
Abstract:
... BACKGROUND: MDA-7/IL-24 cytokine has shown potent antitumor properties in various types of cancer without exerting any significant toxicity on healthy cells. It has also been proved to encompass pro-immune Th1 cytokine-like behavior. Several E7 DNA vaccines have developed against human papillomavirus (HPV)-related cervical cancer. However, the restricted immunogenicity has limited their clinical a ...
DOI:
10.1186/s12985-022-01842-x

19. Production of a Bacteria-like Particle Vaccine Targeting Rock Bream (Oplegnathus fasciatus) Iridovirus Using Nicotiana benthamiana

Author:
Gyeongik Ahn; Joon-Yung Cha; Jeong Won Lee; Gyeongran Park; Gyeong-Im Shin; Shi-Jian Song; Gyeongryul Ryu; Inhwan Hwang; Min Gab Kim; Woe-Yeon Kim
Source:
Journal of plant biology 2022 v.65 no.1 pp. 21-28
ISSN:
1226-9239
Subject:
recombinant vaccines,   etc   ; Iridovirus; Lactococcus lactis; Nicotiana benthamiana; Oplegnathus fasciatus; affinity chromatography; ammonium sulfate; coat proteins; enzyme-linked immunosorbent assay; gel chromatography; immunogenicity; lysine; mice; recombinant proteins; tobacco; trichloroacetic acid;     Show all 16 Subjects
Abstract:
... Viral diseases are extremely widespread infections that change constantly through mutations. To produce vaccines against viral diseases, transient expression systems are employed, and Nicotiana benthamiana (tobacco) plants are a rapidly expanding platform. In this study, we developed a recombinant protein vaccine targeting the major capsid protein (MCP) of iridovirus fused with the lysine motif (L ...
DOI:
10.1007/s12374-021-09328-z

20. Recombinant Ehrlichia canis GP19 Protein as a Promising Vaccine Prototype Providing a Protective Immune Response in a Mouse Model

Author:
Boondarika Nambooppha; Amarin Rittipornlertrak; Anucha Muenthaisong; Pongpisid Koonyosying; Paweena Chomjit; Kanokwan Sangkakam; Sahatchai Tangtrongsup; Saruda Tiwananthagorn; Nattawooti Sthitmatee
Source:
Veterinary sciences 2022 v.9 no.8 pp. -
ISSN:
2306-7381
Subject:
recombinant vaccines,   etc   ; B-lymphocytes; CD4-positive T-lymphocytes; DNA; Ehrlichia canis; antibodies; antibody formation; bacteria; definitive hosts; dogs; ehrlichiosis; flow cytometry; gene expression; liver; mice; models; pathogens; prototypes; spleen; vaccine development;     Show all 20 Subjects
Abstract:
... The intracellular bacterium Ehrlichia canis is the causative pathogen of canine monocytic ehrlichiosis (CME) in dogs. Despite its veterinary and medical importance, there is currently no available vaccine against this pathogen. In this study, the recombinant GP19 (rGP19) was produced and used as a recombinant vaccine prototype in a mouse model against experimental E. canis infection. The efficacy ...
DOI:
10.3390/vetsci9080386