PubAg

Main content area

You searched for: Subject "sclerosis" Remove constraint Subject: "sclerosis"
Start Over

Search

1,423  Search Results

« Previous | 1 - 20 of 1,423 |
Number of results to display per page

Search Results

1. Modeling and Prediction of Multiple Correlated Functional Outcomes

Author:
Cao, Jiguo; Soiaporn, Kunlaya; Carroll, Raymond J.; Ruppert, David
Source:
Journal of agricultural, biological, and environmental statistics 2019 v.24 no.1 pp. 112-129
ISSN:
1085-7117
Subject:
sclerosis,   etc   ; algorithms; image analysis; models; patients; prediction;     Show all 6 Subjects
Abstract:
... We propose a copula-based approach for analyzing functional data with correlated multiple functional outcomes exhibiting heterogeneous shape characteristics. To accommodate the possibly large number of parameters due to having several functional outcomes, parameter estimation is performed in two steps: first, the parameters for the marginal distributions are estimated using the skew t family, and ...
DOI:
10.1007/s13253-018-00344-0

2. Location-adjusted Wald statistics for scalar parameters

Author:
Di Caterina, Claudia; Kosmidis, Ioannis
Source:
Computational statistics & data analysis 2019 v.138 pp. 126-142
ISSN:
0167-9473
Subject:
sclerosis,   etc   ; algorithms; computer software; magnetic resonance imaging; models; regression analysis;     Show all 6 Subjects
Abstract:
... Inference about a scalar parameter of interest is a core statistical task that has attracted immense research in statistics. The Wald statistic is a prime candidate for the task, on the grounds of the asymptotic validity of the standard normal approximation to its finite-sample distribution, simplicity and low computational cost. It is well known, though, that this normal approximation can be inad ...
DOI:
10.1016/j.csda.2019.04.004

3. On the behavioral economics of medication choice: A research story

Author:
Jarmolowicz, David P.; Reed, Derek D.; Bruce, Amanda S.; Bruce, Jared M.
Source:
Behavioural processes 2019 v.165 pp. 66-77
ISSN:
0376-6357
Subject:
sclerosis,   etc   ; drug therapy; economics; obesity; overeating; patients; substance abuse;     Show all 7 Subjects
Abstract:
... Behavioral economics has been consistently useful in describing a wide range of clinical phenomena, particularly in reference to behavioral excesses such as substance abuse, problematic gambling and obesity/overeating. Given an opportunity to explore these processes as they relate to treatment adherence in patients with multiple sclerosis (MS), our central thesis was that behavioral economic tools ...
DOI:
10.1016/j.beproc.2019.05.019

4. CT and gross pathology are comparable methods for detecting some degenerative sacroiliac joint lesions in dogs

Author:
Carnevale, Michael; Jones, Jeryl; Holásková, Ida; Sponenberg, D. Phillip
Source:
Veterinary radiology & ultrasound 2019 v.60 no.4 pp. 378-389
ISSN:
1058-8183
Subject:
sclerosis,   etc   ; ankylosis; dogs; humans; image analysis; pain; reference standards;     Show all 7 Subjects
Abstract:
... Degenerative sacroiliac joint disease is a cause of lumbosacral pain in dogs; however, published information on cross‐sectional imaging characteristics is limited. Objectives of this retrospective, secondary analysis, methods‐comparison study were to test hypotheses that CT lesions reported in humans with degenerative sacroiliac joint disease are also present in dogs, and that CT is comparable to ...
DOI:
10.1111/vru.12749
CHORUS:
10.1111/vru.12749

5. Hepatitis B vaccination and central demyelination – History, description and observed/expected analyses of 624 cases reported to the French pharmacovigilance over a 20-year period

Author:
Mouchet, Julie; Bégaud, Bernard
Source:
Vaccine 2019 v.37 no.15 pp. 2142-2148
ISSN:
0264-410X
Subject:
sclerosis,   etc   ; adults; hepatitis B; neonates; surveys; vaccination; vaccines; women; France;     Show all 9 Subjects
Abstract:
... Confidence in vaccines is essential for achieving targeted immunization coverage. The current skepticism about vaccine safety feeds on controversies such as the suspicion about a link between hepatitis B (HB) vaccination and central demyelination (CD) after the massive HB immunization campaign in France in 1994–2000. This study assesses the robustness of this signal by analysing all validated case ...
DOI:
10.1016/j.vaccine.2019.02.046

6. Brain Aging and Gut–Brain Axis

Author:
Mohajeri, M. Hasan
Source:
Nutrients 2019 v.11 no.2
ISSN:
2072-6643
Subject:
sclerosis,   etc   ; brain; intestinal microorganisms; microbiome; neurodegenerative diseases; pathophysiology;     Show all 6 Subjects
Abstract:
... In the last decade, the microbiome in general and the gut microbiome in particular have been associated not only to brain development and function, but also to the pathophysiology of brain aging and to neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), depression, or multiple sclerosis (MS) [...] ...
DOI:
10.3390/nu11020424

7. Brain Aging and Gut–Brain Axis

Author:
Mohajeri, M. Hasan
Source:
Nutrients 2019 v.11 no.2
ISSN:
2072-6643
Subject:
sclerosis,   etc   ; brain; intestinal microorganisms; microbiome; neurodegenerative diseases; pathophysiology;     Show all 6 Subjects
Abstract:
... In the last decade, the microbiome in general and the gut microbiome in particular have been associated not only to brain development and function, but also to the pathophysiology of brain aging and to neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), depression, or multiple sclerosis (MS) [...] ...
DOI:
10.3390/nu11020424

8. Comparison of the prokaryotic and eukaryotic microbial communities in peripheral blood from amyotrophic lateral sclerosis, multiple sclerosis, and control populations

Author:
Ellis, Jeremy E.; Missan, Dara S.; Shabilla, Matthew; Moschonas, Constantine; Saperstein, David; Martinez, Delyn; Becker, Christian V.; Fry, Stephen E.
Source:
Human microbiome journal 2019 pp. 100060
ISSN:
2452-2317
Subject:
amyotrophic lateral sclerosis; sclerosis,   etc   ; Americans; DNA; DNA fingerprinting; Ochrophyta; blood; blood sampling; high-throughput nucleotide sequencing; humans; microbial communities; microbiome; multivariate analysis; nucleotide sequences; patients;     Show all 15 Subjects
Abstract:
... Neurodegenerative diseases are estimated to afflict hundreds of thousands of Americans with vastly more worldwide. The etiologies of amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) have yet to be established. Previous studies have suggested an association of these diseases with viruses, bacteria, and eukaryotic microbes, no new therapies have been forthcoming. High-throughput DNA s ...
DOI:
10.1016/j.humic.2019.100060

9. RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Author:
Liao, Ya-Cheng; Fernandopulle, Michael S.; Wang, Guozhen; Choi, Heejun; Hao, Ling; Drerup, Catherine M.; Patel, Rajan; Qamar, Seema; Nixon-Abell, Jonathon; Shen, Yi; Meadows, William; Vendruscolo, Michele; Knowles, Tuomas P.J.; Nelson, Matthew; Czekalska, Magdalena A.; Musteikyte, Greta; Gachechiladze, Mariam A.; Stephens, Christina A.; Pasolli, H. Amalia; Forrest, Lucy R.; St George-Hyslop, Peter; Lippincott-Schwartz, Jennifer; Ward, Michael E.
Source:
Cell 2019 v.179 no.1 pp. 147-164.e20
ISSN:
0092-8674
Subject:
amyotrophic lateral sclerosis,   etc   ; RNA; RNA transport; granules; lysosomes; microscopy; mutation; neurons; protein synthesis; proteins; proteomics; separation;     Show all 12 Subjects
Abstract:
... Long-distance RNA transport enables local protein synthesis at metabolically-active sites distant from the nucleus. This process ensures an appropriate spatial organization of proteins, vital to polarized cells such as neurons. Here, we present a mechanism for RNA transport in which RNA granules “hitchhike” on moving lysosomes. In vitro biophysical modeling, live-cell microscopy, and unbiased prox ...
DOI:
10.1016/j.cell.2019.08.050

10. Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms

Author:
Evans, Chantell S.; Holzbaur, Erika L.F.
Source:
Journal of molecular biology 2019
ISSN:
0022-2836
Subject:
amyotrophic lateral sclerosis,   etc   ; endoplasmic reticulum; homeostasis; mitochondria; mitophagy; neurons; protein aggregates; quality control;     Show all 8 Subjects
Abstract:
... The cargo-specific removal of organelles via selective autophagy is important to maintain neuronal homeostasis. Genetic studies indicate that deficits in these pathways are implicated in neurodegenerative diseases, including Parkinson's and amyotrophic lateral sclerosis. Here, we review our current understanding of the pathways that regulate mitochondrial quality control, and compare these mechani ...
DOI:
10.1016/j.jmb.2019.06.031

11. Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway

Author:
Jo, Myungjin; Lee, Shinrye; Kim, Kiyoung; Lee, Seongsoo; Kim, Sang Ryong; Kim, Hyung-Jun
Source:
Biochemical and biophysical research communications 2019 v.513 no.4 pp. 925-932
ISSN:
0006-291X
Subject:
amyotrophic lateral sclerosis,   etc   ; Alzheimer disease; Parkinson disease; autophagy; death; enzymes; neurons; protein aggregates; therapeutics; toxicity;     Show all 10 Subjects
Abstract:
... The most prominent hallmarks of many neurodegenerative diseases are the accumulation of misfolded protein aggregates and the death of certain neuronal populations. Autophagy is the major intracellular mechanism that degrades protein aggregates and damaged cellular components. Many studies have reported that the dysfunction of autophagy is associated with several neurodegenerative diseases, such as ...
DOI:
10.1016/j.bbrc.2019.04.088

12. The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration

Author:
Ferreira, Paulo A.
Source:
Cellular and molecular life sciences 2019 v.76 no.12 pp. 2247-2273
ISSN:
1420-682X
Subject:
amyotrophic lateral sclerosis,   etc   ; homeostasis; motor neurons; nuclear pore; nucleocytoplasmic transport; pathogenesis;     Show all 6 Subjects
Abstract:
... The nuclear pore is the gatekeeper of nucleocytoplasmic transport and signaling through which a vast flux of information is continuously exchanged between the nuclear and cytoplasmic compartments to maintain cellular homeostasis. A unifying and organizing principle has recently emerged that cements the notion that several forms of amyotrophic lateral sclerosis (ALS), and growing number of other ne ...
DOI:
10.1007/s00018-019-03029-0

13. The role of orphan G protein-coupled receptors in the pathophysiology of multiple sclerosis: A review

Author:
Alavi, Mohaddeseh Sadat; Karimi, Gholamreza; Roohbakhsh, Ali
Source:
Life sciences 2019 v.224 pp. 33-40
ISSN:
0024-3205
Subject:
sclerosis,   etc   ; Alzheimer disease; G-protein coupled receptors; Parkinson disease; drugs; pathophysiology; transmembrane proteins;     Show all 7 Subjects
Abstract:
... G protein-coupled receptors (GPCRs) are a large family of transmembrane proteins that are expressed in many organs and serve as important drug targets. A new subgroup, namely orphan GPCRs, comprising many of these receptors has been discovered. These receptors exhibit diverse physiological functions and have been considered in many neurological disorders including Alzheimer's disease, Parkinson's ...
DOI:
10.1016/j.lfs.2019.03.045

14. Antisense oligonucleotide therapies for Amyotrophic Lateral Sclerosis: Existing and emerging targets

Author:
Klim, Joseph R.; Vance, Caroline; Scotter, Emma L.
Source:
The international journal of biochemistry & cell biology 2019 v.110 pp. 149-153
ISSN:
1357-2725
Subject:
amyotrophic lateral sclerosis,   etc   ; RNA; disease course; drugs; oligonucleotides; pathogenesis; patients; therapeutics;     Show all 8 Subjects
Abstract:
... Amyotrophic lateral sclerosis (ALS) is a disease with highly heterogenous causes, most of which remain unknown, a multitude of possible disease mechanisms, and no therapy currently available that can halt disease progression. However, recent advances in antisense oligonucleotides have made them a viable option for targeted therapeutics for patients. These molecules offer a method of targeting RNA ...
DOI:
10.1016/j.biocel.2019.03.009

15. Metabolic regulation of TH17 cells

Author:
Shen, Hongxing; Shi, Lewis Zhichang
Source:
Molecular immunology 2019 v.109 pp. 81-87
ISSN:
0161-5890
Subject:
sclerosis,   etc   ; Crohn disease; T-lymphocytes; autoimmune diseases; cell differentiation; colitis; glucose; lipogenesis; pathogenicity; phenotype; psoriasis; therapeutics;     Show all 12 Subjects
Abstract:
... IL-17-producing TH17 cells have been associated with autoimmune diseases such as multiple sclerosis (MS), psoriasis, Crohn’s disease, and ulcerative colitis (Han et al., 2015), many of which lack effective therapies. Identifying effective approaches to selectively suppress TH17 cell development and function represents a legitimate strategy to cure these autoimmune disorders. TH17 cell differentiat ...
DOI:
10.1016/j.molimm.2019.03.005

16. Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Author:
Haukedal, Henriette; Freude, Kristine
Source:
Journal of molecular biology 2019 v.431 no.9 pp. 1818-1829
ISSN:
0022-2836
Subject:
amyotrophic lateral sclerosis,   etc   ; autophagy; central nervous system; dementia; genes; inflammation; mutation; neuroglia; neurons; pathogenesis; protein degradation;     Show all 11 Subjects
Abstract:
... Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with clear similarities regarding their clinical, genetic and pathological features. Both are progressive, lethal disorders, with no current curative treatment available. Several genes that correlated with ALS and FTD are implicated in the same molecular pathways. Strikingly, many of these genes a ...
DOI:
10.1016/j.jmb.2019.02.004

17. Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins

Author:
Darling, April L.; Breydo, Leonid; Rivas, Emma G.; Gebru, Niad T.; Zheng, Dali; Baker, Jeremy D.; Blair, Laura J.; Dickey, Chad A.; Koren, John; Uversky, Vladimir N.
Source:
International journal of biological macromolecules 2019 v.127 pp. 136-145
ISSN:
0141-8130
Subject:
amyotrophic lateral sclerosis,   etc   ; RNA; dementia; dipeptides; microsatellite repeats; mutation; proteins; translation (genetics);     Show all 8 Subjects
Abstract:
... A microsatellite expansion mutation in C9orf72 is the most common genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The expansion mutation leads to C9orf72 loss of function, RNA foci formation, and generation of five species of non-AUG RAN translated dipeptide repeat proteins (DPRs), such as poly(GA), poly(GP), poly(GR), poly(PA), and poly(PR). Although one ce ...
DOI:
10.1016/j.ijbiomac.2019.01.035

18. Association between Allelic Variants of IL2, IL2RA, and IL7R Genes and Multiple Sclerosis

Author:
Timasheva, Y. R.; Zaplakhova, O. V.; Nasibullin, T. R.; Tuktarova, I. A.; Erdman, V. V.; Bakhtiiarova, K. Z.; Mustafina, O. E.
Source:
Russian journal of genetics 2019 v.55 no.4 pp. 487-494
ISSN:
1022-7954
Subject:
sclerosis,   etc   ; algorithms; alleles; environmental factors; genotype; interleukin-2; interleukin-7; loci; nervous system;     Show all 9 Subjects
Abstract:
... Multiple sclerosis is a chronic progressive disease of nervous system caused by a combination of genetic and environmental factors leading to the development of a complex of autoimmune and neurodegenerative processes. We performed the analysis of association between multiple sclerosis and polymorphic markers of interleukin-2 (IL2), interleukin-2 receptor alpha chain (IL2A) and interleukin-7 recept ...
DOI:
10.1134/S1022795419030153

19. Exploring the aggregation-prone regions from structural domains of human TDP-43 Proteins and proteomics

Author:
Kumar, Vijay; Wahiduzzaman,; Prakash, Amresh; Tomar, Anil Kumar; Srivastava, Ankit; Kundu, Bishwajit; Lynn, Andrew M.; Imtaiyaz Hassan, Md.
Source:
Biochimica et biophysica acta 2019 v.1867 no.3 pp. 286-296
ISSN:
1570-9639
Subject:
amyotrophic lateral sclerosis,   etc   ; DNA-binding proteins; RNA; algorithms; amyloid; dementia; humans; molecular dynamics; peptides;     Show all 9 Subjects
Abstract:
... TDP-43 (transactive- response DNA binding protein) amazes structural biologist as its aberrant ubiquitinated cytosolic inclusions is largely involved in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). An important question in TDP-43 research is to identify the structural region mediating the formation of cytoplasmic pathological aggregates. ...
DOI:
10.1016/j.bbapap.2018.10.008

20. Total chemical synthesis by native chemical ligation of the all-D immunoglobulin-like domain 2 of Axl

Author:
De Rosa, Lucia; Di Stasi, Rossella; D'Andrea, Luca Domenico
Source:
Tetrahedron 2019 v.75 no.7 pp. 894-905
ISSN:
0040-4020
Subject:
sclerosis,   etc   ; chemical reactions; enzymes; ligands; neoplasms; organic compounds; peptide libraries; screening; synthesis;     Show all 9 Subjects
Abstract:
... Axl is a tyrosine kinases receptor playing crucial role in several cellular responses. The deregulation of Axl signaling has been associated to many high impact diseases ranging from cancer to multiple sclerosis. We report the successful procedure for the chemical synthesis of the Ig2 domain of Axl, one of the key extracellular regions of the receptor involved in ligand binding. The protein was sy ...
DOI:
10.1016/j.tet.2019.01.005