PubAg

Main content area

You searched for: Subject "sclerosis" Remove constraint Subject: "sclerosis"
Start Over

Search

1,581  Search Results

« Previous | 1 - 20 of 1,581 |
Number of results to display per page

Search Results

1. Tuberous sclerosis complex 1 (PvTSC1) participates in ammonia nitrogen induced oxidative stress in Penaeus vannamei by regulating autophagy

Author:
Wang, Feifei; Liang, Qingjian; Liu, Can; Dong, Wenna; Ou, Mufei; Li, Zhonghua; Liu, Yuan; Wang, Weina
Source:
Aquaculture 2021 v.533 pp. 736107
ISSN:
0044-8486
Subject:
sclerosis,   etc   ; Litopenaeus vannamei; amino acid sequences; amino acids; ammonium nitrogen; antioxidant enzymes; autophagy; cytoplasm; genes; hemocytes; hepatopancreas; messenger RNA; mortality; open reading frames; oxidative stress; polypeptides; shrimp; tissues;     Show all 18 Subjects
Abstract:
... The tuberous sclerosis complex 1 (TSC1) is a critical upstream regulator of autophagy. Nevertheless, the detailed molecular mechanism of TSC1 and its function in crustacean are still not well understood. In the present study, TSC1 was identified and characterized from Penaeus vannamei. Molecular feature analysis revealed that the open reading frame (ORF) of PvTSC1 was 3516 bp encoding a polypeptid ...
DOI:
10.1016/j.aquaculture.2020.736107

2. TCDD attenuates EAE through induction of FasL on B cells and inhibition of IgG production

Author:
Kummari, Evangel; Rushing, Erin; Nicaise, Ashleigh; McDonald, Amye; Kaplan, Barbara L.F.
Source:
Toxicology 2021 v.448 pp. 152646
ISSN:
0300-483X
Subject:
sclerosis,   etc   ; B-lymphocytes; T-lymphocytes; apoptosis; coculture; encephalitis; humans; immunoglobulin G; ligands; membrane potential; mice; mitochondrial membrane; models; spinal cord; spleen; splenocytes; tetrachlorodibenzo-p-dioxin;     Show all 17 Subjects
Abstract:
... Previously we demonstrated that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed experimental autoimmune encephalomyelitis (EAE), a model to study multiple sclerosis (MS), through induction of regulatory T cells (Tregs) and suppression of effector T cell function in the spleen. Since B cells and specifically regulatory B cells (Bregs) have been shown to be so critical in the pathology associa ...
DOI:
10.1016/j.tox.2020.152646

3. Discovery and Function of B-Cell IgD Low (BDL) B Cells in Immune Tolerance

Author:
Khalil, Mohamed I.; Gurski, Cody J.; Dittel, Landon J.; Neu, Savannah D.; Dittel, Bonnie N.
Source:
Journal of molecular biology 2021 v.433 no.1 pp. 166584
ISSN:
0022-2836
Subject:
sclerosis,   etc   ; B-lymphocytes; animal disease models; encephalitis; flow cytometry; homeostasis; humoral immunity; immunosuppression; inflammation; ligands; mechanism of action; mice; phenotype; therapeutics; tumor necrosis factors;     Show all 15 Subjects
Abstract:
... It is now appreciated that in addition to their role in humoral immunity, B cells also exert regulatory mechanisms that lead to attenuation of inflammatory responses. The concept of B-cell regulation became well recognized when mice deficient in B cells due to genetic disruption were shown to be refractory to recovery from the signs of experimental autoimmune encephalomyelitis (EAE), the mouse mod ...
DOI:
10.1016/j.jmb.2020.06.023

4. Plasma Cells: From Cytokine Production to Regulation in Experimental Autoimmune Encephalomyelitis

Author:
Wang, Angela A.; Gommerman, Jennifer L.; Rojas, Olga L.
Source:
Journal of molecular biology 2021 v.433 no.1 pp. 166655
ISSN:
0022-2836
Subject:
sclerosis,   etc   ; adaptive immunity; animal models; antibodies; antigens; blood plasma; bone marrow; encephalitis; immunization; interleukin-10; interleukin-17; intestines; lymph nodes; patients; phenotype; plasma cells; spleen;     Show all 17 Subjects
Abstract:
... B cells are a critical arm of the adaptive immune system. After encounter with antigen, B cells are activated and differentiate into plasmablasts (PBs) and plasma cells (PCs). Although their frequency is low, PB/PCs can be found in all lymphoid organs including peripheral lymph nodes and spleen. Upon immunization, depending on the location of where B cells encounter their antigen, PB/PCs subsequen ...
DOI:
10.1016/j.jmb.2020.09.014

5. Malnutrition at diagnosis in amyotrophic lateral sclerosis (als) and its influence on survival: Using glim criteria

Author:
López-Gómez, Juan José; Ballesteros-Pomar, María D.; Torres-Torres, Beatriz; De la Maza, Begoña Pintor; Penacho-Lázaro, M. Ángeles; Palacio-Mures, José M.; Abreu-Padín, Cristina; López-Guzmán, Antonio; De Luis-Román, Daniel A.
Source:
Clinical nutrition 2021 v.40 no.1 pp. 237-244
ISSN:
0261-5614
Subject:
amyotrophic lateral sclerosis,   etc   ; bioelectrical impedance; body mass index; clinical nutrition; diet therapy; disease progression; hospitals; leadership; malnutrition; medical history; mortality; motor neurons; multivariate analysis; nutritional status; patients; risk factors; weight loss; Spain;     Show all 18 Subjects
Abstract:
... Malnutrition is a prognostic factor in Amyotrophic Lateral Sclerosis (ALS). Sometimes, this condition is underdiagnosed, and it might influence on disease progression.To evaluate a) nutritional status at the beginning of specialized nutritional treatment and b) the influence of initial nutritional status on disease evolution and survival in a group of patients with amyotrophic lateral sclerosis (A ...
DOI:
10.1016/j.clnu.2020.05.014

6. The effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) use on cerebral glucose metabolism in multiple sclerosis: a pilot study

Author:
Workman, Craig D.; Kindred, John H.; Boles Ponto, Laura L.; Kamholz, John; Rudroff, Thorsten
Source:
Applied physiology, nutrition and metabolism 2020 v.45 no.4 pp. 450-452
ISSN:
1715-5320
Subject:
sclerosis,   etc   ; cannabidiol; glucose; metabolic diseases; metabolism; nutrition;     Show all 6 Subjects
Abstract:
... This exploratory pilot study investigated the effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on cerebral glucose metabolism in people with multiple sclerosis (PwMS). Compared with nonusers, THC users had hypermetabolism of 3 regions (p < 0.039, d >1.17) in left temporal areas, while CBD users had hypometabolism of 5 regions (p < 0.032, d > 1.31) in left temporal areas. Thi ...
DOI:
10.1139/apnm-2019-0634

7. Conformational dynamics of superoxide dismutase (SOD1) in osmolytes: a molecular dynamics simulation study

Author:
Jahan, Ishrat; Nayeem, Shahid M.
Source:
RSC advances 2020 v.10 no.46 pp. 27598-27614
ISSN:
2046-2069
Subject:
amyotrophic lateral sclerosis,   etc   ; hydrophobicity; molecular dynamics; superoxide dismutase; trimethylamine; urea;     Show all 6 Subjects
Abstract:
... Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by the misfolding of Cu, Zn superoxide dismutase (SOD1). Several earlier studies have shown that monomeric apo SOD1 undergoes significant local unfolding dynamics and is the predecessor for aggregation. Here, we have employed atomistic molecular dynamics (MD) simulations to study the structure and dynamics of mon ...
DOI:
10.1039/d0ra02151b

8. The roles of neuron-NG2 glia synapses in promoting oligodendrocyte development and remyelination

Author:
Li, Rongrong; Zhang, Pu; Zhang, Mao; Yao, Zhongxiang
Source:
Cell and tissue research 2020 v.381 no.1 pp. 43-53
ISSN:
0302-766X
Subject:
sclerosis,   etc   ; brain; myelination; neurons; oligodendroglia; stem cells; synapse;     Show all 7 Subjects
Abstract:
... NG2 immunopositive progenitor cells, also simply termed as NG2 glia and thought mainly to be oligodendrocyte precursor cells (OPCs), form synaptic connections with neurons in gray and white matters of brain. One of the most classical features of oligodendrocyte lineage cells is myelination, which will favor neuronal signaling transmission. Thus, is there a causal link between the specific synapses ...
DOI:
10.1007/s00441-020-03195-9

9. Incidence of multiple sclerosis in the province of Catania. A geo-epidemiological study

Author:
Nicoletti, Alessandra; Rascunà, Cristina; Boumediene, Farid; Vasta, Rosario; Cicero, Calogero Edoardo; Lo Fermo, Salvatore; Ferrante, Margherita; Marziolo, Roberto; Maimone, Davide; Grimaldi, Luigi Maria; Preux, Pierre-Marie; Patti, Francesco; Zappia, Mario
Source:
Environmental research 2020 v.182 pp. 109022
ISSN:
0013-9351
Subject:
sclerosis,   etc   ; cluster analysis; metals; risk; trade winds; women;     Show all 6 Subjects
Abstract:
... An increasing incidence of MS in the city of Catania was reported during 1975–2004, with a higher incidence along the south-eastern flank of the Mt.Etna. We evaluated the incidence of MS in the entire province of Catania during 2005–2015 and the spatial distribution of MS-cases using a cluster analysis.Patients were considered as incident MS-cases if they fulfilled the revised McDonald criteria fo ...
DOI:
10.1016/j.envres.2019.109022

10. Siponimod Chips Away at Progressive MS

Author:
Longbrake, Erin E.; Hafler, David A.
Source:
Cell 2019 v.179 no.7 pp. 1440
ISSN:
0092-8674
Subject:
sclerosis,   etc   ; magnetic resonance imaging; patients;     Show all 3 Subjects
Abstract:
... Progressive multiple sclerosis (PMS) causes slow accumulation of neurologic disability and has been refractory to treatment with the immunomodulatory medications that effectively control relapsing MS. Siponimod modestly slowed the rate of disability progression among PMS patients who had inflammatory disease activity, evidenced by new or gadolinium-enhancing MRI lesions. To view this Bench to Beds ...
DOI:
10.1016/j.cell.2019.11.034

11. Evaluation and optimization of common lipid extraction methods in cerebrospinal fluid samples

Author:
Reichl, Bernd; Eichelberg, Nicole; Freytag, Matilda; Gojo, Johannes; Peyrl, Andreas; Buchberger, Wolfgang
Source:
Journal of chromatography 2020 v.1153 pp. 122271
ISSN:
1570-0232
Subject:
amyotrophic lateral sclerosis; sclerosis,   etc   ; Alzheimer disease; Parkinson disease; acidification; blood serum; brain neoplasms; cerebrospinal fluid; chromatography; equipment; lipid content; lipidomics; liquid-liquid extraction; mixing; solvents; sphingolipids; temperature;     Show all 17 Subjects
Abstract:
... A typical lipidomics approach aims at the simultaneous analysis of a multitude of lipid species from different lipid classes with highest possible sensitivity for all target lipids. Efficient extraction of lipids from the biological matrix is a crucial step in the analytical workflow. Whereas numerous applications of classical and more recently published extraction methods have been reported for b ...
DOI:
10.1016/j.jchromb.2020.122271

12. Therapeutic use of cannabis and cannabinoids: an evidence mapping and appraisal of systematic reviews

Author:
Montero-Oleas, Nadia; Arevalo-Rodriguez, Ingrid; Nuñez-González, Solange; Viteri-García, Andrés; Simancas-Racines, Daniel
Source:
BMC complementary medicine and therapies 2020 v.20 no.1 pp. 12
ISSN:
2662-7671
Subject:
sclerosis,   etc   ; Alzheimer disease; Parkinson disease; anorexia; cannabinoids; drug therapy; epilepsy; glaucoma; neoplasms; pain; systematic review; vomiting;     Show all 12 Subjects
Abstract:
... BACKGROUND: Although cannabis and cannabinoids are widely used with therapeutic purposes, their claimed efficacy is highly controversial. For this reason, medical cannabis use is a broad field of research that is rapidly expanding. Our objectives are to identify, characterize, appraise, and organize the current available evidence surrounding therapeutic use of cannabis and cannabinoids, using evid ...
DOI:
10.1186/s12906-019-2803-2
PubMed:
32020875
PubMed Central:
PMC7076827

13. Insight into the Autosomal-Dominant Inheritance Pattern of SOD1-Associated ALS from Native Mass Spectrometry

Author:
Cveticanin, Jelena; Mondal, Tridib; Meiering, Elizabeth M.; Sharon, Michal; Horovitz, Amnon
Source:
Journal of molecular biology 2020 v.432 no.23 pp. 5995-6002
ISSN:
0022-2836
Subject:
amyotrophic lateral sclerosis,   etc   ; dimerization; disease severity; mass spectrometry; mutants; mutation; superoxide dismutase;     Show all 7 Subjects
Abstract:
... About 20% of all familial amyotrophic lateral sclerosis (ALS) cases are associated with mutations in superoxide dismutase (SOD1), a homodimeric protein. The disease has an autosomal-dominant inheritance pattern. It is, therefore, important to determine whether wild-type and mutant SOD1 subunits self-associate randomly or preferentially. A measure for the extent of bias in subunit association is th ...
DOI:
10.1016/j.jmb.2020.09.025

14. Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models

Author:
Han, Qian; Tang, Hua-zheng; Zou, Min; Zhao, Jie; Wang, Ling; Bian, Zhao-xiang; Li, Yan-hong
Source:
Journal of natural products 2020 v.83 no.6 pp. 1939-1949
ISSN:
1520-6025
Subject:
sclerosis,   etc   ; adverse effects; berberine; colon; cytokines; dextran sulfate; immunomodulators; mice; models; oral administration; sphingosine; ulcerative colitis;     Show all 12 Subjects
Abstract:
... The natural alkaloid berberine is being studied as a drug candidate for the treatment of ulcerative colitis (UC). Fingolimod is an immunomodulator approved for the treatment of multiple sclerosis. Whether fingolimod use can be extended to UC and how it interacts with berberine remain unclear. In the present study, the anti-inflammatory efficacies of berberine, fingolimod, and a combination of half ...
DOI:
10.1021/acs.jnatprod.0c00175

15. Phase angle could be a marker of microvascular damage in systemic sclerosis

Author:
Gigante, Antonietta; Gasperini, Maria Ludovica; Rosato, Edoardo; Navarini, Luca; Margiotta, Domenico; Afeltra, Antonella; Muscaritoli, Maurizio
Source:
Nutrition 2020 v.73 pp. 110730
ISSN:
0899-9007
Subject:
sclerosis,   etc   ; autoimmune diseases; disease severity; endothelial cells; females; fibrosis; males; patients; vascular endothelial growth factors;     Show all 9 Subjects
Abstract:
... Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction with fibrosis of skin and internal organs. Integrity of the endothelial cell is important to its physiologic function such as production of angiogenetic factors. The aim of this study was to assess whether phase angle (PhA) is altered in patients with SSc and whether its values correlate with vascular endoth ...
DOI:
10.1016/j.nut.2020.110730

16. Pathomechanism Heterogeneity in the Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Disease Spectrum: Providing Focus Through the Lens of Autophagy

Author:
Casterton, Rebecca L.; Hunt, Rachel J.; Fanto, Manolis
Source:
Journal of molecular biology 2020 v.432 no.8 pp. 2692-2713
ISSN:
0022-2836
Subject:
amyotrophic lateral sclerosis,   etc   ; RNA; autophagy; dementia; disease incidence; genes; metabolism; motor neurons; patients; proteins;     Show all 10 Subjects
Abstract:
... Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) constitute aggressive neurodegenerative pathologies that lead to the progressive degeneration of upper and lower motor neurons and of neocortical areas, respectively. In the past decade, the identification of several genes that cause these disorders indicated that the two diseases overlap in a multifaceted spectrum of conditions ...
DOI:
10.1016/j.jmb.2020.02.018

17. Liquid–Liquid Phase Separation and Its Mechanistic Role in Pathological Protein Aggregation

Author:
Babinchak, W. Michael; Surewicz, Witold K.
Source:
Journal of molecular biology 2020 v.432 no.7 pp. 1910-1925
ISSN:
0022-2836
Subject:
amyotrophic lateral sclerosis,   etc   ; Alzheimer disease; amyloid; chemical interactions; hydrogels; organelles; separation; toxicity;     Show all 8 Subjects
Abstract:
... Liquid–liquid phase separation (LLPS) of proteins underlies the formation of membrane-less organelles. While it has been recognized for some time that these organelles are of key importance for normal cellular functions, a growing number of recent observations indicate that LLPS may also play a role in disease. In particular, numerous proteins that form toxic aggregates in neurodegenerative diseas ...
DOI:
10.1016/j.jmb.2020.03.004

18. Unveiling the structural features of nonnative trimers of human superoxide dismutase 1

Author:
Chao, Wei-Chih; Lu, Jyh-Feng; Wang, Jinn-Shyan; Chiang, Tzu-Hsuan; Lin, Li-Ju; Lee, Yao-Lin; Chou, Pi-Tai
Source:
Biochimica et biophysica acta 2020 v.1864 no.3 pp. 129483
ISSN:
0304-4165
Subject:
amyotrophic lateral sclerosis,   etc   ; catalytic activity; fluorescence; gel chromatography; humans; mutants; neurotoxicity; proteins; stabilizers; superoxide dismutase; tryptophan;     Show all 11 Subjects
Abstract:
... Human SOD1 contains a single tryptophan residue (W32) which has been identified as a site of oxidative modification and a potentiator of aggregation involving in familial amyotrophic lateral sclerosis (fALS). In situ substitution of a tryptophan analog, 2,6-diazatryptophan ((2,6-aza)Trp) with its unique water-catalyzed proton transfer property, into proteins exhibits extraordinary sensitivity in t ...
DOI:
10.1016/j.bbagen.2019.129483

19. Solid-State NMR Reveals the Structural Transformation of the TDP-43 Amyloidogenic Region upon Fibrillation

Author:
Zhuo, Xiao-Feng; Wang, Jian; Zhang, Jing; Jiang, Lei-Lei; Hu, Hong-Yu; Lu, Jun-Xia
Source:
Journal of the American Chemical Society 2020 v.142 no.7 pp. 3412-3421
ISSN:
1520-5126
Subject:
amyotrophic lateral sclerosis,   etc   ; X-ray diffraction; amyloid; biomarkers; indoles; nuclear magnetic resonance spectroscopy; separation; thioredoxins;     Show all 8 Subjects
Abstract:
... TDP-43 is a primary pathological hallmark protein of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, which may exist in the form of amyloid inclusions in the cells of patients. In addition to serving as a biomarker for these diseases, TDP-43 can also directly trigger neurodegeneration. We previously determined the amyloidogenic core region of TDP-43 (residues 311–360) and show ...
DOI:
10.1021/jacs.9b10736

20. Ophthalmic examination findings and intraocular pressure measurements in six species of anura

Author:
Hausmann, Jennifer C.; Weaver, Thomas J.; Freeman, Kate S.
Source:
Journal of zoo and wildlife medicine 2020 v.50 no.4 pp. 845-852
ISSN:
1937-2825
Subject:
sclerosis,   etc   ; Anaxyrus boreas; Phyllomedusa; Trachycephalus resinifictrix; cataract; dogs; eyes; frogs; glaucoma; lipids; monkeys; toads; Lake Titicaca;     Show all 13 Subjects
Abstract:
... A complete ophthalmic exam, including intraocular pressure (IOP) measurement, is key to diagnosing ocular diseases such as uveitis and glaucoma in frogs. We performed complete ophthalmic anterior segment examinations and IOP rebound tonometry measurements using two different settings (other “p” and canine “d”) for six anuran species. The objectives were to describe common ocular abnormalities foun ...
DOI:
10.1638/2019-0115