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... In this issue of Molecular Cell, Alerasool et al. (2022) present a proteome-scale functional screen to systematically uncover human proteins that can activate transcription. ...
screening, etc ; RNA; chemical communication; fluorescence; lipids; proteins; Show all 6 Subjects
Abstract:
... We develop for the first time a label-free fluorescent method for sensitive detection of fat mass and obesity-associated protein (FTO) activity using MazF-mediated primer generation rolling circle amplification. This method is very simple with ultrahigh sensitivity and good specificity, and it can detect FTO activity at the single-cell level. Moreover, this method can be applied for the measuremen ...
screening, etc ; computer software; environmental models; life cycle assessment; regression analysis; testing; Show all 6 Subjects
Abstract:
... Global sensitivity analysis (GSA) is a valuable tool for filtering out non-influential model inputs. In combination with robustness, convergence and validation analyses, GSA can be particularly beneficial in interpreting and simplifying models with tens of thousands of independent inputs. However, there is lack of research on robust screening of such large models, where the curse of dimensionality ...
screening, etc ; decision making; environmental factors; exhibitions; expert opinion; solutions; sustainable development; uncertainty; weight; wills; Show all 10 Subjects
Abstract:
... Selecting a proper set of projects is an important issue to make crucial decisions for many project-oriented organizations enabling them to achieve their goals despite the existing operational constraints (resources, time, etc.) and competitive environments. Since the results and consequences of the selected projects have short-term and long-range effects on social, economic, and environmental con ...
... A set of cyclopentanoid α-galactosidase ligands was prepared from a partially protected ω-eno-aldose via a reliable (2 + 3)-cycloaddition protocol with slightly modified conditions. The obtained N-benzylisoxazolidine ring was selectively opened and the configuration of the hydroxymethylgroup was inverted. Consecutive deprotection provided an aminocyclopentane, which was N-alkylated to furnish a se ...
screening, etc ; age; college students; eating disorders; eating habits; health care workers; regression analysis; sampling; United States; Show all 9 Subjects
Abstract:
... This study aimed to determine the associations between psychosis symptoms and eating disorders among a national sample of college and university students ages 18 to 26 years. Data from the 2020–2021 Healthy Minds Study (United States) were analyzed (N = 96,791). Multiple modified Poisson regression analyses were conducted to estimate the association between four self-reported lifetime psychosis sy ...
high-throughput screening methods; screening, etc ; anisotropy; artificial intelligence; cations; density functional theory; journals; materials; models; prediction; production costs; solar cells; Show all 12 Subjects
Abstract:
... Double hybrid organic–inorganic perovskites (DHOIPs) with excellent optoelectronic properties and low production costs are promising in photovoltaic applications. However, DHOIPs still have not been investigated thoroughly, due to their structural complexities. In this work, an accelerated discovery of DHOIPs has been realized by combining machine learning (ML) techniques, high-throughput screenin ...
screening, etc ; chromatography; journals; objectives; reaction kinetics; wills; Show all 6 Subjects
Abstract:
... Method screening is an integral part of chromatographic method development for the separation of racemates. Due to the highly complex retention mechanism of a chiral stationary-phase, it is often difficult, if not impossible, to device predefined method-development steps that can be successfully applied to a wide group of molecules. The standard approach is to evaluate or screen a series of statio ...
screening, etc ; bacteriophages; chemical communication; peptide libraries; proteins; Show all 5 Subjects
Abstract:
... A peptide-type covalent binder for a target protein was obtained by direct and stringent screening of a warhead-modified peptide library on the robust T7 phage. The aryl fluorosulfate (fosylate) warhead was activated only in a matchmaking microenvironment created between the target protein and an appropriate peptide during the reactivity/affinity-based co-selection process of extended phage displa ...
screening, etc ; coatings; manufacturing; solar cells; spectroscopy; utilities; Show all 6 Subjects
Abstract:
... Small-area metal–halide perovskite solar cells (PSCs) having power-conversion efficiencies (PCEs) of greater than 25% can be prepared by using a spin-coated perovskite layer, but this technique is not readily transferrable to large-scale manufacturing. Drop-casting is a simple alternative method for film formation that is more closely aligned to industry-relevant coating processes. In the present ...
Šarūnas Svirskas; Sergejus Balčiūnas; Mantas Šimėnas; Gediminas Usevičius; Martynas Kinka; Martynas Velička; Dominik Kubicki; Marianela Escobar Castillo; Andrei Karabanov; Vladimir V. Shvartsman; Maria de Rosário Soares; Valdas Šablinskas; Andrei N. Salak; Doru C. Lupascu; Jūras Banys
screening, etc ; crystals; dielectrics; journals; materials; phase transition; temperature; Show all 7 Subjects
Abstract:
... In this reply, we address the concerns that were raised about our paper on CsPbBr₃ single crystals. M. Szafrański criticized the dielectric and DSC data in our original paper claiming that they were affected by the experimental artefacts or poor quality of the investigated single crystals, as his DSC and dielectric data did not show any low temperature anomalies in CsPbBr₃. We argue in this reply ...
screening, etc ; catalysts; catalytic activity; chemical communication; emissions; models; montmorillonite; Show all 7 Subjects
Abstract:
... Herein, we demonstrated for the first time that customized aggregation-induced emission luminogens can be utilized to directly visualize heterogeneous catalytic organic reactions, which further enables catalyst screening. We used the retro-Diels–Alder reaction as a model reaction for illustration, and identified montmorillonite K10 as the best catalyst in our catalyst screening. ...
screening, etc ; catalysts; cations; oxides; physicochemical properties; transition elements; wills; Show all 7 Subjects
Abstract:
... Spinel oxides are promising low-cost catalysts with manifold and controllable physicochemical properties. Trial and error strategies cannot achieve the effective screening of high-performance spinel catalysts. Therefore, unraveling the structure–performance relationship is the foundation for their rational design. Herein, the effects of cations in tetrahedral and octahedral sites on the electronic ...
screening, etc ; alternative medicine; educational methods; funding; libraries; stakeholders; wills; Show all 7 Subjects
Abstract:
... BACKGROUND: Over the past few decades, the popularity of complementary and alternative medicine (CAM) has grown considerably and along with it, scrutiny regarding its evidence base. While this is to be expected, and is in line with other health disciplines, research in CAM is confronted by numerous obstacles. This scoping review aims to identify and report the strategies implemented to address bar ...
screening, etc ; bottles; bottling; hands; humans; motors; prediction; volunteerism; volunteers; Show all 9 Subjects
Abstract:
... Voluntary movements include a predictive control of the sensory-motor consequences of executed or observed actions. The motor system predicts further steps of actions relying on its pure observation. This study seeks to disclose the interference of an implicit motor prediction effect during actions reconstruction. Videos of human actions directed to objects were presented to volunteers. Subsequent ...
screening, etc ; Bivalvia; equations; forces; hosts; mammals; neoplasms; prediction; sheds; Show all 9 Subjects
Abstract:
... Transmissible cancers are elusive and understudied parasitic life forms caused by malignant clonal cells (nine lineages are known so far). They emerge by completing sequential steps that include breaking cell cooperation, evade anti‐cancer defences and shedding cells to infect new hosts. Transmissible cancers impair host fitness, and their importance as selective force is likely largely underestim ...
screening, etc ; couplings; crossing; energy flow; systems analysis; testing; wills; Show all 7 Subjects
Abstract:
... With the increasing coupling among multiple energy systems, component failure of one system may spread to other systems, which results in cross-system failures that will remarkably affect the operation state of RIES. In this regard, this paper proposes a probabilistic energy flow calculation approach for regional integrated energy system (RIES), taking into account those cross-system failures (CSF ...
high-throughput screening methods; screening, etc ; automation; droplets; microfluidic technology; Show all 5 Subjects
Abstract:
... Droplet microfluidic technology has emerged as a powerful tool for biological analysis and screening. Currently, there is an urgent need to develop a versatile microfluidic droplet technique that can be adapted to different applications and widely adopted in routine laboratories. In this review, we introduce automated, flexible and versatile manipulation systems for nanoliter-to-picoliter droplets ...
screening, etc ; adsorption; exhibitions; gases; journals; materials; separation; sieves; sieving; temperature; Show all 10 Subjects
Abstract:
... Sodalite zeolitic-imidazole frameworks (ZIFs) show great potential due to their effective aperture sizes suitable for small gas separations. Numerous efforts have, therefore, been made in tuning their effective aperture sizes to control and enhance their molecular sieving properties. Herein, we present a new strategy to finely tune the effective aperture size of CdIF-1, a cadmium-substituted ZIF-8 ...
screening, etc ; exhibitions; mass; materials; photovoltaic cells; shortenings; thermal stability; wills; Show all 8 Subjects
Abstract:
... Lead-free double perovskites are regarded as stable and green optoelectronic alternatives to single perovskites, but may exhibit indirect band gaps and high effective masses, thus limiting their maximum photovoltaic efficiency. Considering that the trial-and-error experimental and computational approaches cannot quickly identify ideal candidates, we propose an ensemble learning workflow to screen ...