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... In this issue of Molecular Cell, Alerasool et al. (2022) present a proteome-scale functional screen to systematically uncover human proteins that can activate transcription. ...
screening, etc ; Americans; journals; regression analysis; Show all 4 Subjects
Abstract:
... This article proposes a model-free and data-adaptive feature screening method for ultrahigh-dimensional data. The proposed method is based on the projection correlation which measures the dependence between two random vectors. This projection correlation based method does not require specifying a regression model, and applies to data in the presence of heavy tails and multivariate responses. It en ...
screening, etc ; deformation; enantiomers; prediction; spectral analysis; Show all 5 Subjects
Abstract:
... Theoretical screenings of D₄-molecular cylinders for high-g chiroptical molecules were performed to find one four-panel cycloarylene with an anomalously high theoretical gₐbₛ,cₐₗc value of 1.97. Optical resolutions of enantiomers after developments of elaborate syntheses allowed for spectral analyses of the chiral D₄-cylinder. Unexpectedly, the experimental gₐbₛ value was three orders of magnitude ...
screening, etc ; RNA; chemical communication; fluorescence; lipids; proteins; Show all 6 Subjects
Abstract:
... We develop for the first time a label-free fluorescent method for sensitive detection of fat mass and obesity-associated protein (FTO) activity using MazF-mediated primer generation rolling circle amplification. This method is very simple with ultrahigh sensitivity and good specificity, and it can detect FTO activity at the single-cell level. Moreover, this method can be applied for the measuremen ...
screening, etc ; antibodies; biosensors; chemical communication; fluorescence; neoplasm cells; Show all 6 Subjects
Abstract:
... We develop for the first time a label-free and self-circulated fluorescent biosensor for sensitive detection of ten-eleven translocation 1 (TET1) activity in cancer cells. This biosensor displays good specificity and high sensitivity without the need for any antibodies/exogenous primers and it can accurately quantify TET1 activity at the single-cell level. Moreover, it can be employed for the meas ...
screening, etc ; dimensions; lasers; manufacturing; nanomaterials; photoinhibition; refractive index; wafers; Show all 8 Subjects
Abstract:
... For decades, photoinhibited two-photon lithography (PI-TPL) has been continually developed and applied into versatile nanofabrication. However, ultrahigh precision fabrication on wafer by PI-TPL remains challenging, due to the lack of a refractive index (n) matched photoresist (Rim-P) with effective photoinhibition capacity for dip-in mode. In this paper, various Rim-P are developed and then scree ...
screening, etc ; batteries; design; energy; prediction; probability; solids; statistical models; Show all 8 Subjects
Abstract:
... Retired batteries are widely repurposed in energy storage packs as an economical and eco-friendly method to achieve echelon utilization. However, pack performance is strongly affected by variations in retired cells and pack configuration. Quantifying this effect in various pack configurations considering cell-to-cell variations is crucial for predicting the performance of numerous packs. Therefore ...
screening, etc ; catalysts; catalytic activity; chemical communication; emissions; models; montmorillonite; Show all 7 Subjects
Abstract:
... Herein, we demonstrated for the first time that customized aggregation-induced emission luminogens can be utilized to directly visualize heterogeneous catalytic organic reactions, which further enables catalyst screening. We used the retro-Diels–Alder reaction as a model reaction for illustration, and identified montmorillonite K10 as the best catalyst in our catalyst screening. ...
screening, etc ; drugs; oligomerization; protein conformation; protein-protein interactions; proteins; Show all 6 Subjects
Abstract:
... Dynamic protein complexes function in all cellular processes, from signaling to transcription, using distinct conformations that regulate their activity. Conformational switching of proteins can turn on or off their activity through protein–protein interactions, catalytic function, cellular localization, or membrane interaction. Recent advances in structural, computational, and chemical methodolog ...
screening, etc ; couplings; crossing; energy flow; systems analysis; testing; wills; Show all 7 Subjects
Abstract:
... With the increasing coupling among multiple energy systems, component failure of one system may spread to other systems, which results in cross-system failures that will remarkably affect the operation state of RIES. In this regard, this paper proposes a probabilistic energy flow calculation approach for regional integrated energy system (RIES), taking into account those cross-system failures (CSF ...
screening, etc ; computer software; environmental models; life cycle assessment; regression analysis; testing; Show all 6 Subjects
Abstract:
... Global sensitivity analysis (GSA) is a valuable tool for filtering out non-influential model inputs. In combination with robustness, convergence and validation analyses, GSA can be particularly beneficial in interpreting and simplifying models with tens of thousands of independent inputs. However, there is lack of research on robust screening of such large models, where the curse of dimensionality ...
screening, etc ; econometrics; exhibitions; journals; regression analysis; rooting; roots; signal strength; twins; Show all 9 Subjects
Abstract:
... Explanatory variables in a predictive regression typically exhibit low signal strength and various degrees of persistence. Variable selection in such a context is of great importance. In this paper, we explore the pitfalls and possibilities of the LASSO methods in this predictive regression framework. In the presence of stationary, local unit root, and cointegrated predictors, we show that the ada ...
screening, etc ; adults; bones; boning; genetic disorders; neoplasms; patient care; patients; risk; skin lesions; Show all 10 Subjects
Abstract:
... Neurofibromatosis type 1 (NF1) is one of the most common genetic neurocutaneous disorders. The hallmark of this disease is skin lesions in the form of café-au-lait spots, ephelides, and the characteristic cutaneous neurofibromas. Other common manifestations include bone abnormalities, “NF1 vasculopathy,” and neurocognitive disorders. In addition, patients are at an increased risk for a wide variet ...
screening, etc ; absorption; additives; electric potential difference; exhibitions; journals; length; organic salts; solar cells; Show all 9 Subjects
Abstract:
... Wide bandgap perovskite solar cells have gained extensive attention due to their complementary absorption to fabricate high performance tandem solar cells with low bandgap absorbers, whereas the open-circuit voltage (VOC) loss caused by halide segregation and defects is one of the main issues hindering their performance. Herein, we report a strategy of adding organic bromide salts with different c ...
screening, etc ; decision making; environmental factors; exhibitions; expert opinion; solutions; sustainable development; uncertainty; weight; wills; Show all 10 Subjects
Abstract:
... Selecting a proper set of projects is an important issue to make crucial decisions for many project-oriented organizations enabling them to achieve their goals despite the existing operational constraints (resources, time, etc.) and competitive environments. Since the results and consequences of the selected projects have short-term and long-range effects on social, economic, and environmental con ...
screening, etc ; age; college students; eating disorders; eating habits; health care workers; regression analysis; sampling; United States; Show all 9 Subjects
Abstract:
... This study aimed to determine the associations between psychosis symptoms and eating disorders among a national sample of college and university students ages 18 to 26 years. Data from the 2020–2021 Healthy Minds Study (United States) were analyzed (N = 96,791). Multiple modified Poisson regression analyses were conducted to estimate the association between four self-reported lifetime psychosis sy ...
... Dual-phase CO₂ separation membrane consisting of molten carbonates confined in a solid matrix can separate CO₂ at high temperatures. The contact angle of molten carbonates to different oxides that can potentially serve as membrane supports was screened between 450 and 650 °C. These oxides have different electrical transport properties, including oxide ion, mixed, and electronic conducting. The con ...
screening, etc ; artificial intelligence; computational methodology; data collection; digital libraries; models; molecular dynamics; polymers; prediction; quantitative structure-activity relationships; Show all 10 Subjects
Abstract:
... As a fundamental structure characteristic in polymers, fractional free volume (FFV) plays an indispensable role in governing polymer properties and performance. However, the design of new high-FFV polymers is challenging. In this study, we report a data-driven approach and aim to accelerate the discovery of high-FFV polymers. First, a computational method is proposed to calculate FFV, and a two-st ...
screening, etc ; acids; aquatic environment; chemical treatment; drinking water treatment; households; per- and polyfluoroalkyl substances; planting; tap water; unit process; Show all 10 Subjects
Abstract:
... The massive use and the persistence of per- and polyfluoroalkyl substances (PFAS) have led to their frequent detection in aquatic environments, which may further threaten drinking water safety. So far, our knowledge about the occurrence of PFAS in drinking water system is still very limited. Here we investigated the occurrence and removal of PFAS in a drinking water system using non-target, suspec ...
... A set of cyclopentanoid α-galactosidase ligands was prepared from a partially protected ω-eno-aldose via a reliable (2 + 3)-cycloaddition protocol with slightly modified conditions. The obtained N-benzylisoxazolidine ring was selectively opened and the configuration of the hydroxymethylgroup was inverted. Consecutive deprotection provided an aminocyclopentane, which was N-alkylated to furnish a se ...