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1. Proteome-scale identification of transcriptional activators in human cells

Author:
Filip Nemčko; Alexander Stark
Source:
Molecular cell 2022 v.82 no.3 pp. 497-499
ISSN:
1097-2765
Subject:
screening,   etc   ; cells; humans; transactivators;     Show all 4 Subjects
Abstract:
... In this issue of Molecular Cell, Alerasool et al. (2022) present a proteome-scale functional screen to systematically uncover human proteins that can activate transcription. ...
DOI:
10.1016/j.molcel.2022.01.006

2. Model-Free Feature Screening and FDR Control With Knockoff Features

Author:
Wanjun Liu; Yuan Ke; Jingyuan Liu; Runze Li
Source:
Journal of the American Statistical Association 2022 v.117 no.537 pp. 428-443
ISSN:
1537-274X
Subject:
screening,   etc   ; Americans; journals; regression analysis;     Show all 4 Subjects
Abstract:
... This article proposes a model-free and data-adaptive feature screening method for ultrahigh-dimensional data. The proposed method is based on the projection correlation which measures the dependence between two random vectors. This projection correlation based method does not require specifying a regression model, and applies to data in the presence of heavy tails and multivariate responses. It en ...
DOI:
10.1080/01621459.2020.1783274

3. A large-bore chiral cylindrical molecule prone to radial deformations

Author:
Yuzuka Onaka; Shun Tanaka; Ayano Kobayashi; Taisuke Matsuno; Hiroyuki Isobe
Source:
Tetrahedron letters 2022 v.96 pp. 153774
ISSN:
0040-4039
Subject:
screening,   etc   ; deformation; enantiomers; prediction; spectral analysis;     Show all 5 Subjects
Abstract:
... Theoretical screenings of D₄-molecular cylinders for high-g chiroptical molecules were performed to find one four-panel cycloarylene with an anomalously high theoretical gₐbₛ,cₐₗc value of 1.97. Optical resolutions of enantiomers after developments of elaborate syntheses allowed for spectral analyses of the chiral D₄-cylinder. Unexpectedly, the experimental gₐbₛ value was three orders of magnitude ...
DOI:
10.1016/j.tetlet.2022.153774

4. Label-free and sensitive detection of RNA demethylase FTO with primer generation rolling circle amplification

Author:
Xiaoxia Han; Yueying Li; Zi-Yue Wang; Ling-Zhi Liu; Jian-Ge Qiu; Bing-Jie Liu; Chun-yang Zhang
Source:
Chemical communications 2022 v.58 no.10 pp. 1565-1568
ISSN:
1364-548X
Subject:
screening,   etc   ; RNA; chemical communication; fluorescence; lipids; proteins;     Show all 6 Subjects
Abstract:
... We develop for the first time a label-free fluorescent method for sensitive detection of fat mass and obesity-associated protein (FTO) activity using MazF-mediated primer generation rolling circle amplification. This method is very simple with ultrahigh sensitivity and good specificity, and it can detect FTO activity at the single-cell level. Moreover, this method can be applied for the measuremen ...
DOI:
10.1039/d1cc06493b

5. A label-free and self-circulated fluorescent biosensor for sensitive detection of ten-eleven translocation 1 in cancer cells

Author:
Wen-jing Liu; Xinyi Zhang; Juan Hu; Chun-yang Zhang
Source:
Chemical communications 2022 v.58 no.57 pp. 7996-7999
ISSN:
1364-548X
Subject:
screening,   etc   ; antibodies; biosensors; chemical communication; fluorescence; neoplasm cells;     Show all 6 Subjects
Abstract:
... We develop for the first time a label-free and self-circulated fluorescent biosensor for sensitive detection of ten-eleven translocation 1 (TET1) activity in cancer cells. This biosensor displays good specificity and high sensitivity without the need for any antibodies/exogenous primers and it can accurately quantify TET1 activity at the single-cell level. Moreover, it can be employed for the meas ...
DOI:
10.1039/d2cc03019e

6. Dip-In Photoresist for Photoinhibited Two-Photon Lithography to Realize High-Precision Direct Laser Writing on Wafer

Author:
Chun Cao; Yiwei Qiu; Lingling Guan; Zhen Wei; Zhenyao Yang; Lanxin Zhan; Dazhao Zhu; Chenliang Ding; Xiaoming Shen; Xianmeng Xia; Cuifang Kuang; Xu Liu
Source:
ACS applied materials & interfaces 2022 v.14 no.27 pp. 31332-31342
ISSN:
1944-8252
Subject:
screening,   etc   ; dimensions; lasers; manufacturing; nanomaterials; photoinhibition; refractive index; wafers;     Show all 8 Subjects
Abstract:
... For decades, photoinhibited two-photon lithography (PI-TPL) has been continually developed and applied into versatile nanofabrication. However, ultrahigh precision fabrication on wafer by PI-TPL remains challenging, due to the lack of a refractive index (n) matched photoresist (Rim-P) with effective photoinhibition capacity for dip-in mode. In this paper, various Rim-P are developed and then scree ...
DOI:
10.1021/acsami.2c08063

7. Statistical relationships between numerous retired lithium-ion cells and packs with random sampling for echelon utilization

Author:
Chen Ma; Long Chang; Naxin Cui; Bin Duan; Yulong Zhang; Zhihao Yu
Source:
Energy 2022 v.257 pp. 124692
ISSN:
0360-5442
Subject:
screening,   etc   ; batteries; design; energy; prediction; probability; solids; statistical models;     Show all 8 Subjects
Abstract:
... Retired batteries are widely repurposed in energy storage packs as an economical and eco-friendly method to achieve echelon utilization. However, pack performance is strongly affected by variations in retired cells and pack configuration. Quantifying this effect in various pack configurations considering cell-to-cell variations is crucial for predicting the performance of numerous packs. Therefore ...
DOI:
10.1016/j.energy.2022.124692

8. In situ observation of heterogeneous catalytic organic reactions via aggregation-induced emission luminogens

Author:
Jinzhao Ji; Jinying Yuan; Yen Wei
Source:
Chemical communications 2022 v.58 no.10 pp. 1601-1604
ISSN:
1364-548X
Subject:
screening,   etc   ; catalysts; catalytic activity; chemical communication; emissions; models; montmorillonite;     Show all 7 Subjects
Abstract:
... Herein, we demonstrated for the first time that customized aggregation-induced emission luminogens can be utilized to directly visualize heterogeneous catalytic organic reactions, which further enables catalyst screening. We used the retro-Diels–Alder reaction as a model reaction for illustration, and identified montmorillonite K10 as the best catalyst in our catalyst screening. ...
DOI:
10.1039/d1cc06706k

9. Targeting protein conformations with small molecules to control protein complexes

Author:
Emmanouil Zacharioudakis; Evripidis Gavathiotis
Source:
Trends in biochemical sciences 2022 pp. -
ISSN:
0968-0004
Subject:
screening,   etc   ; drugs; oligomerization; protein conformation; protein-protein interactions; proteins;     Show all 6 Subjects
Abstract:
... Dynamic protein complexes function in all cellular processes, from signaling to transcription, using distinct conformations that regulate their activity. Conformational switching of proteins can turn on or off their activity through protein–protein interactions, catalytic function, cellular localization, or membrane interaction. Recent advances in structural, computational, and chemical methodolog ...
DOI:
10.1016/j.tibs.2022.07.002

10. Probabilistic energy flow calculation for regional integrated energy system considering cross-system failures

Author:
Hang Li; Kai Hou; Xiandong Xu; Hongjie Jia; Lewei Zhu; Yunfei Mu
Source:
Applied energy 2022 v.308 pp. 118326
ISSN:
0306-2619
Subject:
screening,   etc   ; couplings; crossing; energy flow; systems analysis; testing; wills;     Show all 7 Subjects
Abstract:
... With the increasing coupling among multiple energy systems, component failure of one system may spread to other systems, which results in cross-system failures that will remarkably affect the operation state of RIES. In this regard, this paper proposes a probabilistic energy flow calculation approach for regional integrated energy system (RIES), taking into account those cross-system failures (CSF ...
DOI:
10.1016/j.apenergy.2021.118326

11. Robust high-dimensional screening

Author:
Aleksandra Kim; Christopher Mutel; Andreas Froemelt
Source:
Environmental modelling & software 2022 v.148 pp. 105270
ISSN:
1364-8152
Subject:
screening,   etc   ; computer software; environmental models; life cycle assessment; regression analysis; testing;     Show all 6 Subjects
Abstract:
... Global sensitivity analysis (GSA) is a valuable tool for filtering out non-influential model inputs. In combination with robustness, convergence and validation analyses, GSA can be particularly beneficial in interpreting and simplifying models with tens of thousands of independent inputs. However, there is lack of research on robust screening of such large models, where the curse of dimensionality ...
DOI:
10.1016/j.envsoft.2021.105270

12. On LASSO for predictive regression

Author:
Ji Hyung Lee; Zhentao Shi; Zhan Gao
Source:
Journal of econometrics 2022 v.229 no.2 pp. 322-349
ISSN:
0304-4076
Subject:
screening,   etc   ; econometrics; exhibitions; journals; regression analysis; rooting; roots; signal strength; twins;     Show all 9 Subjects
Abstract:
... Explanatory variables in a predictive regression typically exhibit low signal strength and various degrees of persistence. Variable selection in such a context is of great importance. In this paper, we explore the pitfalls and possibilities of the LASSO methods in this predictive regression framework. In the presence of stationary, local unit root, and cointegrated predictors, we show that the ada ...
DOI:
10.1016/j.jeconom.2021.02.002

13. Diagnostic and follow-up protocol for adult patients with neurofibromatosis type 1 in a Spanish reference unit

Author:
I. Solares; D. Vinal; M. Morales-Conejo
Source:
Revista clínica española 2022 v.222 no.8 pp. 486-495
ISSN:
2254-8874
Subject:
screening,   etc   ; adults; bones; boning; genetic disorders; neoplasms; patient care; patients; risk; skin lesions;     Show all 10 Subjects
Abstract:
... Neurofibromatosis type 1 (NF1) is one of the most common genetic neurocutaneous disorders. The hallmark of this disease is skin lesions in the form of café-au-lait spots, ephelides, and the characteristic cutaneous neurofibromas. Other common manifestations include bone abnormalities, “NF1 vasculopathy,” and neurocognitive disorders. In addition, patients are at an increased risk for a wide variet ...
DOI:
10.1016/j.rceng.2022.02.007

14. Suppressed Halide Segregation and Defects in Wide Bandgap Perovskite Solar Cells Enabled by Doping Organic Bromide Salt with Moderate Chain Length

Author:
Xiaomin Huo; Yaoyao Li; Yao Lu; Jie Dong; Yu Zhang; Suling Zhao; Bo Qiao; Dong Wei; Dandan Song; Zheng Xu
Source:
Journal of physical chemistry 2022 v.126 no.4 pp. 1711-1720
ISSN:
1932-7455
Subject:
screening,   etc   ; absorption; additives; electric potential difference; exhibitions; journals; length; organic salts; solar cells;     Show all 9 Subjects
Abstract:
... Wide bandgap perovskite solar cells have gained extensive attention due to their complementary absorption to fabricate high performance tandem solar cells with low bandgap absorbers, whereas the open-circuit voltage (VOC) loss caused by halide segregation and defects is one of the main issues hindering their performance. Herein, we report a strategy of adding organic bromide salts with different c ...
DOI:
10.1021/acs.jpcc.1c09739

15. Performance evaluation of sustainable projects: a possibilistic integrated novel analytic hierarchy process-data envelopment analysis approach using Z-Number information

Author:
Ali RezaHoseini; Zahra Rahmani; Morteza BagherPour
Source:
Environment, development and sustainability 2022 v.24 no.3 pp. 3198-3257
ISSN:
1387-585X
Subject:
screening,   etc   ; decision making; environmental factors; exhibitions; expert opinion; solutions; sustainable development; uncertainty; weight; wills;     Show all 10 Subjects
Abstract:
... Selecting a proper set of projects is an important issue to make crucial decisions for many project-oriented organizations enabling them to achieve their goals despite the existing operational constraints (resources, time, etc.) and competitive environments. Since the results and consequences of the selected projects have short-term and long-range effects on social, economic, and environmental con ...
DOI:
10.1007/s10668-021-01565-z

16. Associations between psychosis symptoms and eating disorders among a national sample of U.S. college students

Author:
Kyle T. Ganson; Kelly Cuccolo; Jason M. Nagata
Source:
Eating behaviors 2022 v.45 pp. 101622
ISSN:
1471-0153
Subject:
screening,   etc   ; age; college students; eating disorders; eating habits; health care workers; regression analysis; sampling; United States;     Show all 9 Subjects
Abstract:
... This study aimed to determine the associations between psychosis symptoms and eating disorders among a national sample of college and university students ages 18 to 26 years. Data from the 2020–2021 Healthy Minds Study (United States) were analyzed (N = 96,791). Multiple modified Poisson regression analyses were conducted to estimate the association between four self-reported lifetime psychosis sy ...
DOI:
10.1016/j.eatbeh.2022.101622

17. Contact angle screening and asymmetric dual-phase CO2 separation membranes

Author:
Wen Xing; Anne Støre
Source:
Journal of membrane science 2022 v.652 pp. 120447
ISSN:
0376-7388
Subject:
screening,   etc   ; asymmetric membranes; carbon dioxide; carbonates; contact angle; electrical properties; exhibitions; ions; journals; measurement; mixing; seals; solids; temperature;     Show all 14 Subjects
Abstract:
... Dual-phase CO₂ separation membrane consisting of molten carbonates confined in a solid matrix can separate CO₂ at high temperatures. The contact angle of molten carbonates to different oxides that can potentially serve as membrane supports was screened between 450 and 650 °C. These oxides have different electrical transport properties, including oxide ion, mixed, and electronic conducting. The con ...
DOI:
10.1016/j.memsci.2022.120447

18. Accelerating Discovery of High Fractional Free Volume Polymers from a Data-Driven Approach

Author:
Mao Wang; Jianwen Jiang
Source:
ACS applied materials & interfaces 2022 v.14 no.27 pp. 31203-31215
ISSN:
1944-8252
Subject:
screening,   etc   ; artificial intelligence; computational methodology; data collection; digital libraries; models; molecular dynamics; polymers; prediction; quantitative structure-activity relationships;     Show all 10 Subjects
Abstract:
... As a fundamental structure characteristic in polymers, fractional free volume (FFV) plays an indispensable role in governing polymer properties and performance. However, the design of new high-FFV polymers is challenging. In this study, we report a data-driven approach and aim to accelerate the discovery of high-FFV polymers. First, a computational method is proposed to calculate FFV, and a two-st ...
DOI:
10.1021/acsami.2c03917

19. Per- and polyfluoralkyl substances (PFAS) in drinking water system: Target and non-target screening and removal assessment

Author:
Yu-Qing Wang; Li-Xin Hu; Ting Liu; Jia-Hui Zhao; Yuan-Yuan Yang; You-Sheng Liu; Guang-Guo Ying
Source:
Environment international 2022 v.163 pp. 107219
ISSN:
0160-4120
Subject:
screening,   etc   ; acids; aquatic environment; chemical treatment; drinking water treatment; households; per- and polyfluoroalkyl substances; planting; tap water; unit process;     Show all 10 Subjects
Abstract:
... The massive use and the persistence of per- and polyfluoroalkyl substances (PFAS) have led to their frequent detection in aquatic environments, which may further threaten drinking water safety. So far, our knowledge about the occurrence of PFAS in drinking water system is still very limited. Here we investigated the occurrence and removal of PFAS in a drinking water system using non-target, suspec ...
DOI:
10.1016/j.envint.2022.107219

20. New α-galactosidase-inhibiting aminohydroxycyclopentanes

Author:
Patrick Weber; Roland Fischer; Seyed A. Nasseri; Arnold E. Stütz; Martin Thonhofer; Stephen G. Withers; Andreas Wolfsgruber; Tanja M. Wrodnigg
Source:
RSC advances 2021 v.11 no.26 pp. 15943-15951
ISSN:
2046-2069
Subject:
screening,   etc   ; glycosidases; ligands;     Show all 3 Subjects
Abstract:
... A set of cyclopentanoid α-galactosidase ligands was prepared from a partially protected ω-eno-aldose via a reliable (2 + 3)-cycloaddition protocol with slightly modified conditions. The obtained N-benzylisoxazolidine ring was selectively opened and the configuration of the hydroxymethylgroup was inverted. Consecutive deprotection provided an aminocyclopentane, which was N-alkylated to furnish a se ...
DOI:
10.1039/d1ra02507d