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1. Comparison between Microcrystalline Celluloses of different grades made by four manufacturers using the SeDeM diagram expert system as a pharmaceutical characterization tool

Author:
Nofrerias, Isaac; Nardi, Anna; Suñé-Pou, Marc; Suñé-Negre, Josep M.; García-Montoya, Encarna; Pérez-Lozano, Pilar; Ticó, Josep R.; Miñarro, Montserrat
Source:
Powder technology 2019 v.342 pp. 780-788
ISSN:
0032-5910
Subject:
screening,   etc   ; biopolymers; compressibility; databases; powders;     Show all 5 Subjects
Abstract:
... The characterization of pharmaceutical powders by means of the SeDeM diagram expert system allows developing a database. This database is a useful tool in pre-formulation steps as initial screening for suitable filler excipients. This study compiles the characterization of 21 powdery Microcrystalline Celluloses (MCC) of different grades (101, 102, 301, 302 and 200) made by four different manufactu ...
DOI:
10.1016/j.powtec.2018.10.048

2. Scientific and economic comparison of outdoor characterisation methods for photovoltaic power plants

Author:
Mühleisen, W.; Hirschl, C.; Brantegger, G.; Neumaier, L.; Spielberger, M.; Sonnleitner, H.; Kubicek, B.; Ujvari, G.; Ebner, R.; Schwark, M.; Eder, G.C.; Voronko, Y.; Knöbl, K.; Stoicescu, L.
Source:
Renewable energy 2019 v.134 pp. 321-329
ISSN:
0960-1481
Subject:
screening,   etc   ; power plants; solar energy; thermography;     Show all 4 Subjects
Abstract:
... Over the last years, the development of innovative, fast and non-destructive characterisation techniques for the detection of PV-module failures and advanced analysis of yield losses in photovoltaic power plants has become a key challenge in scientific research. Besides standard on-site thermographic screening, several novel and easily applied methods were developed and successfully tested. They d ...
DOI:
10.1016/j.renene.2018.11.044

3. Current Situation of Frailty Screening Tools for Older Adults

Author:
Ma, Lina
Source:
The journal of nutrition, health & aging 2019 v.23 no.1 pp. 111-118
ISSN:
1279-7707
Subject:
screening,   etc   ; elderly; health care costs; mortality;     Show all 4 Subjects
Abstract:
... Frailty is a geriatric syndrome associated with adverse outcomes such as falls, disability, and mortality. Frailty is common and contributes to rising health care costs. Early screening and timely tailored intervention may effectively prevent or delay the adverse outcomes in older adults. Studies on frailty and its specific measurement tools are increasing in number, but the debate on the screenin ...
DOI:
10.1007/s12603-018-1123-4

4. Screening of organic solvents for bioprocesses using aqueous-organic two-phase systems

Author:
Rosinha Grundtvig, Inês P.; Heintz, Søren; Krühne, Ulrich; Gernaey, Krist V.; Adlercreutz, Patrick; Hayler, John D.; Wells, Andy S.; Woodley, John M.
Source:
Biotechnology advances 2018 v.36 no.7 pp. 1801-1814
ISSN:
0734-9750
Subject:
screening,   etc   ; environmental hazards; solvents;     Show all 3 Subjects
Abstract:
... The application of conventional organic solvents has been essential in several steps of bioprocesses in order to achieve sufficient economic efficiency. The use of organic solvents is frequently used either to partly or fully replace water in the reaction medium or as a process aid for downstream separation.Nowadays, manufacturers are increasingly requested to avoid and substitute solvents with ha ...
DOI:
10.1016/j.biotechadv.2018.05.007

5. Multiaxial Molecular Ferroelectric Thin Films Bring Light to Practical Applications

Author:
Tang, Yuan-Yuan; Li, Peng-Fei; Liao, Wei-Qiang; Shi, Ping-Ping; You, Yu-Meng; Xiong, Ren-Gen
Source:
Journal of the American Chemical Society 2018 v.140 no.26 pp. 8051-8059
ISSN:
1520-5126
Subject:
screening,   etc   ; temperature; vigor;     Show all 3 Subjects
Abstract:
... Though dominating most of the practical applications, inorganic ferroelectric thin films usually suffer from the high processing temperatures, the substrate limitation, and the complicated fabrication techniques that are high-cost, energy-intensive, and time-consuming. By contrast, molecular ferroelectrics offer more opportunities for the next-generation flexible and wearable devices due to their ...
DOI:
10.1021/jacs.8b04600

6. Identifying the best locations to install flow control devices in sewer networks to enable in-sewer storage

Author:
Leitão, J.P.; Carbajal, J.P.; Rieckermann, J.; Simões, N.E.; Sá Marques, A.; de Sousa, L.M.
Source:
Journal of hydrology 2018 v.556 pp. 371-383
ISSN:
0022-1694
Subject:
screening,   etc   ; algorithms; hydrology; models;     Show all 4 Subjects
Abstract:
... The activation of available in-sewer storage volume has been suggested as a low-cost flood and combined sewer overflow mitigation measure. However, it is currently unknown what the attributes for suitable objective functions to identify the best location for flow control devices are and the impact of those attributes on the results. In this study, we present a novel location model and efficient al ...
DOI:
10.1016/j.jhydrol.2017.11.020

7. Development of a high-content imaging assay for screening compound aggregation

Author:
Jiang, Yong; Hoffman, Ann; Quinque, Geoffrey; Bonnette, William G.; Szewczuk, Lawrence M.; Holbert, Marc A.; Gross, Jeffrey
Source:
Analytical biochemistry 2018
ISSN:
0003-2697
Subject:
screening,   etc   ; image analysis; proteins;     Show all 3 Subjects
Abstract:
... Aggregated compounds can promiscuously and nonspecifically associate with proteins resulting in either false inhibition or activation of many different protein target classes. We developed a high-content imaging assay in a 384-well format using fluorescently labeled target proteins and an Operetta cell imager to screen for compound aggregates that interact with target proteins. The high-throughput ...
DOI:
10.1016/j.ab.2018.08.019

8. Preparation of a chemiluminescence sensor for multi-detection of benzimidazoles in meat based on molecularly imprinted polymer

Author:
Cai, Yi; He, Xin; Cui, Peng Lei; Liu, Jing; Li, Zhao Bin; Jia, Bing Jie; Zhang, Teng; Wang, Jian Ping; Yuan, Wan Zhe
Source:
Food chemistry 2019 v.280 pp. 103-109
ISSN:
0308-8146
Subject:
screening,   etc   ; beef; benzimidazoles; chemiluminescence; detection limit; haptens; mutton; phenols; polymers;     Show all 9 Subjects
Abstract:
... In this study, a molecularly imprinted polymer capable of recognizing 8 benzimidazoles was first synthesized. The computation simulation showed that the shape and size of used template were the main factors influencing its recognition ability. Then the polymer was used as recognition reagent to prepare a chemiluminescence sensor on conventional 96-well microplate. The sample solution and a HRP-lab ...
DOI:
10.1016/j.foodchem.2018.12.052

9. The Optimal Lid Method for the objective definition of cross-section limits in ephemeral gullies

Author:
Castillo, C.; Campo-Bescós, M.A.; Giménez, R.; Pérez, R.; Casalí, J.
Source:
Catena 2019 v.176 pp. 381-393
ISSN:
0341-8162
Subject:
screening,   etc   ; calibration; data collection; humans; models; ravines; topography; uncertainty;     Show all 8 Subjects
Abstract:
... A precise estimation of transversal gully limits is a prerequisite for accurate gully volume assessment. This step has been typically performed by operators through visual interpretation of gully cross-sections (XSs), based on assumptions which have not been reported. The aim is of this study is to evaluate how much uncertainty is involved in the human definition of XS limits and to propose an alt ...
DOI:
10.1016/j.catena.2019.01.032

10. A Reader-Based Assay for m⁶A Writers and Erasers

Author:
Wiedmer, Lars; Eberle, Stefanie Alexandra; Bedi, Rajiv Kumar; Śledź, Paweł; Caflisch, Amedeo
Source:
Analytical chemistry 2019 v.91 no.4 pp. 3078-3084
ISSN:
1520-6882
Subject:
screening,   etc   ; RNA; catalytic activity; energy transfer; fluorescence; methyltransferases; proteins;     Show all 7 Subjects
Abstract:
... We have developed a homogeneous time-resolved fluorescence (HTRF)-based enzyme assay to measure the catalytic activity of N⁶-methyladenosine (m⁶A) methyltransferases and demethylases. The assay detects m⁶A modifications using the natural m⁶A-binding proteins (m⁶A readers). The reaction product or substrate m⁶A-containing RNA and the m⁶A reader protein are fluorescently labeled such that their prox ...
DOI:
10.1021/acs.analchem.8b05500

11. Novel key parameter for eutectic nitrates based nanofluids selection for concentrating solar power (CSP) systems

Author:
Jiang, Zhu; Palacios, Anabel; Lei, Xianzhang; Navarro, M.E.; Qiao, Geng; Mura, Ernesto; Xu, Guizhi; Ding, Yulong
Source:
Applied energy 2019 v.235 pp. 529-542
ISSN:
0306-2619
Subject:
screening,   etc   ; energy; heat transfer; nanofluids; nanoparticles; nitrates; silica; solar energy;     Show all 8 Subjects
Abstract:
... A high-performance heat transfer fluid (HTF) plays a crucial role in the overall performance and efficiency of concentrating solar power (CSP) systems for utilizing solar energy. Molten salt-based nanofluids, which may offer a promising solution to help reduce the size and cost of CSP systems, have attracted increasing attention. However, there is still no comprehensive assessment strategy that co ...
DOI:
10.1016/j.apenergy.2018.10.114

12. Development of artificial neural network tools for predicting sugar yields from inorganic salt-based pretreatment of lignocellulosic biomass

Author:
Moodley, Preshanthan; Rorke, Daneal C.S.; Gueguim Kana, Evariste Bosco
Source:
Bioresource technology 2019 v.273 pp. 682-686
ISSN:
0960-8524
Subject:
screening,   etc   ; biomass; lignocellulose; neural networks; prediction; reducing sugars;     Show all 6 Subjects
Abstract:
... This study developed two Artificial Neural Network (ANN) tools for predicting sugar yields from inorganic salt-based pretreatment of lignocellulosic biomass. Pretreatment data from 90 experimental runs with 8 different input conditions were used to develop a microwave-based and a steam-based model. Both models exhibited high coefficients of determination (R2) of 0.97. Knowledge extraction revealed ...
DOI:
10.1016/j.biortech.2018.11.034

13. Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy

Author:
Ali, Ahmed; Abouleila, Yasmine; Shimizu, Yoshihiro; Hiyama, Eiso; Watanabe, Tomonobu M.; Yanagida, Toshio; Germond, Arno
Source:
Analytical chemistry 2019 v.91 no.4 pp. 2710-2718
ISSN:
1520-6882
Subject:
screening,   etc   ; Raman spectroscopy; mass spectrometry; metabolites; monitoring; pharmacokinetics; tamoxifen;     Show all 7 Subjects
Abstract:
... Monitoring drug uptake, its metabolism, and response on the single-cell level is invaluable for sustaining drug discovery efforts. In this study, we show the possibility of accessing the information about the aforementioned processes at the single-cell level by monitoring the anticancer drug tamoxifen using live single-cell mass spectrometry (LSC–MS) and Raman spectroscopy. First, we explored whet ...
DOI:
10.1021/acs.analchem.8b04393

14. A microfluidic platform with pneumatically switchable single-cell traps for selective intracellular signals probing

Author:
Wang, Yao; Zhu, Jinchi; Chen, Peng; Hu, Liang; Feng, Xiaojun; Du, Wei; Liu, Bi-Feng
Source:
Talanta 2019 v.192 pp. 431-438
ISSN:
0039-9140
Subject:
screening,   etc   ; adenosine triphosphate; biosensors; calcium; calcium signaling; drugs; hydrodynamics; washing;     Show all 8 Subjects
Abstract:
... To investigate rapid suspension cell signaling, a microfluidic platform was urgently needed for flexibly manipulation of single cells and simultaneous generation of controllable chemical signals to stimulate single cells. In this paper, a microfluidic biosensor was developed to monitor intracellular calcium signal, integrated with single-cell trapping, chemical stimulation and releasing. Selective ...
DOI:
10.1016/j.talanta.2018.09.085

15. Extension of process models to predict batch screening results under the influence of moisture based on DEM simulations

Author:
Elskamp, Frederik; Kruggel-Emden, Harald
Source:
Powder technology 2019 v.342 pp. 698-713
ISSN:
0032-5910
Subject:
screening,   etc   ; glass; industrial applications; liquids; models; particle size; powders; prototypes;     Show all 8 Subjects
Abstract:
... Screening is a technical simple but still not fully understood process step, which can be used in a wide field of applications to separate bulk materials according to their particle sizes. A severe issue in screening technologies is that particles frequently prevail in moist conditions, due to effects related to the environment, the material or the process. This is often not preventable, although ...
DOI:
10.1016/j.powtec.2018.10.039

16. DNA G-Quadruplexes as a Template To Direct Cyanine Dyes To Form H-Aggregates and Application of the Self-Assembly Entity as a New G-Quadruplexes Ligands Screening Platform

Author:
Wang, Bo-Lin; Jiang, Chuang
Source:
Analytical chemistry 2019 v.91 no.2 pp. 1541-1547
ISSN:
1520-6882
Subject:
screening,   etc   ; DNA; biocompatible materials; dyes; fluorescence; ligands; nucleic acid conformation;     Show all 7 Subjects
Abstract:
... The organization of organic chromophores to form H-/J-aggregates can result in new biomaterials with unique properties and applications. DNA-template self-assembly is one of the most attractive strategies to guide the formation of chromophore aggregates. However, the DNA templates are mainly limited to canonical nucleic acids structures [single (ss)- and double (ds)-stranded DNA]. DNA G-quadruplex ...
DOI:
10.1021/acs.analchem.8b04677

17. Strategies for the Enrichment and Selection of Genetically Modified Cells

Author:
Ren, Chonghua; Xu, Kun; Segal, David Jay; Zhang, Zhiying
Source:
Trends in biotechnology 2019 v.37 no.1 pp. 56-71
ISSN:
0167-7799
Subject:
screening,   etc   ; gene editing; gene therapy; genome; genomics; loci; nucleases;     Show all 7 Subjects
Abstract:
... Programmable artificial nucleases have transitioned over the past decade from ZFNs and TALENs to CRISPR/Cas systems, which have been ubiquitously used with great success to modify genomes. The efficiencies of knockout and knockin vary widely among distinct cell types and genomic loci and depend on the nuclease delivery and cleavage efficiencies. Moreover, genetically modified cells are almost phen ...
DOI:
10.1016/j.tibtech.2018.07.017

18. Validity and Reliability of Rapid Cognitive Screening Test for Turkish Older Adults

Author:
Koc Okudur, S.; Dokuzlar, O.; Usarel, C.; Soysal, P.; Isik, Ahmet Turan
Source:
The journal of nutrition, health & aging 2019 v.23 no.1 pp. 68-72
ISSN:
1279-7707
Subject:
screening,   etc   ; Alzheimer disease; cognition; cognitive disorders; confidence interval; elderly; patients;     Show all 7 Subjects
Abstract:
... OBJECTIVES: Practical cognitive screening tests, brief and easy-to-administer are needed for primary care. The Rapid Cognitive Screen (RCS) is one of the cognitive screening tests used. The present study aimed to establish the validity and reliability of the Turkish version of RCS (RCS-T) in patients with impaired cognitive status. DESIGN: Prospective validation study. SETTING AND PARTICIPANTS: To ...
DOI:
10.1007/s12603-018-1107-4

19. A comparison of a mini-PEMS and a 1065 compliant PEMS for on-road gaseous and particulate emissions from a light duty diesel truck

Author:
Yang, Jiacheng; Durbin, Thomas D.; Jiang, Yu; Tange, Takeshi; Karavalakis, Georgios; Cocker, David R.; Johnson, Kent C.
Source:
The Science of the total environment 2018 v.640-641 pp. 364-376
ISSN:
0048-9697
Subject:
screening,   etc   ; nitrogen oxides; particulate emissions;     Show all 3 Subjects
Abstract:
... The primary goal of this study was to compare emissions measurements between a 1065 compliant PEMS, and the NTK Compact Emissions Meter (NCEM) capable of measuring NOx, PM, and solid PN. Both units were equipped on a light-duty diesel truck and tested over local, highway, and downtown driving routes. The results indicate that the NOx measurements for the NCEM were within approximately ±10% of thos ...
DOI:
10.1016/j.scitotenv.2018.04.383

20. Movement rules and screening characteristics of rice-threshed mixture separation through a cylinder sieve

Author:
Yuan, Jianbo; Wu, Chongyou; Li, Hua; Qi, Xindan; Xiao, Xingxing; Shi, Xinxin
Source:
Computers and electronics in agriculture 2018 v.154 pp. 320-329
ISSN:
0168-1699
Subject:
screening,   etc   ; air flow; cleaning; grains;     Show all 4 Subjects
Abstract:
... The rice-threshed mixture presents the phenomenon of axial flow and radial stratification under the impact of airflow field, gravitational field, and sieve. We used the method that couples computational fluid dynamics (CFD) with the discrete element method (DEM) to numerically calculate the process described above, and investigated the influence of inlet airflow velocity, diameter and rotating spe ...
DOI:
10.1016/j.compag.2018.09.012