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1. Proteome-scale identification of transcriptional activators in human cells

Author:
Filip Nemčko; Alexander Stark
Source:
Molecular cell 2022 v.82 no.3 pp. 497-499
ISSN:
1097-2765
Subject:
screening,   etc   ; cells; humans; transactivators;     Show all 4 Subjects
Abstract:
... In this issue of Molecular Cell, Alerasool et al. (2022) present a proteome-scale functional screen to systematically uncover human proteins that can activate transcription. ...
DOI:
10.1016/j.molcel.2022.01.006

2. Label-free and sensitive detection of RNA demethylase FTO with primer generation rolling circle amplification

Author:
Xiaoxia Han; Yueying Li; Zi-Yue Wang; Ling-Zhi Liu; Jian-Ge Qiu; Bing-Jie Liu; Chun-yang Zhang
Source:
Chemical communications 2022 v.58 no.10 pp. 1565-1568
ISSN:
1364-548X
Subject:
screening,   etc   ; RNA; chemical communication; fluorescence; lipids; proteins;     Show all 6 Subjects
Abstract:
... We develop for the first time a label-free fluorescent method for sensitive detection of fat mass and obesity-associated protein (FTO) activity using MazF-mediated primer generation rolling circle amplification. This method is very simple with ultrahigh sensitivity and good specificity, and it can detect FTO activity at the single-cell level. Moreover, this method can be applied for the measuremen ...
DOI:
10.1039/d1cc06493b

3. Robust high-dimensional screening

Author:
Aleksandra Kim; Christopher Mutel; Andreas Froemelt
Source:
Environmental modelling & software 2022 v.148 pp. 105270
ISSN:
1364-8152
Subject:
screening,   etc   ; computer software; environmental models; life cycle assessment; regression analysis; testing;     Show all 6 Subjects
Abstract:
... Global sensitivity analysis (GSA) is a valuable tool for filtering out non-influential model inputs. In combination with robustness, convergence and validation analyses, GSA can be particularly beneficial in interpreting and simplifying models with tens of thousands of independent inputs. However, there is lack of research on robust screening of such large models, where the curse of dimensionality ...
DOI:
10.1016/j.envsoft.2021.105270

4. Performance evaluation of sustainable projects: a possibilistic integrated novel analytic hierarchy process-data envelopment analysis approach using Z-Number information

Author:
Ali RezaHoseini; Zahra Rahmani; Morteza BagherPour
Source:
Environment, development and sustainability 2022 v.24 no.3 pp. 3198-3257
ISSN:
1387-585X
Subject:
screening,   etc   ; decision making; environmental factors; exhibitions; expert opinion; solutions; sustainable development; uncertainty; weight; wills;     Show all 10 Subjects
Abstract:
... Selecting a proper set of projects is an important issue to make crucial decisions for many project-oriented organizations enabling them to achieve their goals despite the existing operational constraints (resources, time, etc.) and competitive environments. Since the results and consequences of the selected projects have short-term and long-range effects on social, economic, and environmental con ...
DOI:
10.1007/s10668-021-01565-z

5. New α-galactosidase-inhibiting aminohydroxycyclopentanes

Author:
Patrick Weber; Roland Fischer; Seyed A. Nasseri; Arnold E. Stütz; Martin Thonhofer; Stephen G. Withers; Andreas Wolfsgruber; Tanja M. Wrodnigg
Source:
RSC advances 2021 v.11 no.26 pp. 15943-15951
ISSN:
2046-2069
Subject:
screening,   etc   ; glycosidases; ligands;     Show all 3 Subjects
Abstract:
... A set of cyclopentanoid α-galactosidase ligands was prepared from a partially protected ω-eno-aldose via a reliable (2 + 3)-cycloaddition protocol with slightly modified conditions. The obtained N-benzylisoxazolidine ring was selectively opened and the configuration of the hydroxymethylgroup was inverted. Consecutive deprotection provided an aminocyclopentane, which was N-alkylated to furnish a se ...
DOI:
10.1039/d1ra02507d

6. Associations between psychosis symptoms and eating disorders among a national sample of U.S. college students

Author:
Kyle T. Ganson; Kelly Cuccolo; Jason M. Nagata
Source:
Eating behaviors 2022 v.45 pp. 101622
ISSN:
1471-0153
Subject:
screening,   etc   ; age; college students; eating disorders; eating habits; health care workers; regression analysis; sampling; United States;     Show all 9 Subjects
Abstract:
... This study aimed to determine the associations between psychosis symptoms and eating disorders among a national sample of college and university students ages 18 to 26 years. Data from the 2020–2021 Healthy Minds Study (United States) were analyzed (N = 96,791). Multiple modified Poisson regression analyses were conducted to estimate the association between four self-reported lifetime psychosis sy ...
DOI:
10.1016/j.eatbeh.2022.101622

7. Δ-Machine learning-driven discovery of double hybrid organic–inorganic perovskites

Author:
Jialu Chen; Wenjun Xu; Ruiqin Zhang
Source:
Journal of materials chemistry A 2022 v.10 no.3 pp. 1402-1413
ISSN:
2050-7496
Subject:
high-throughput screening methods; screening,   etc   ; anisotropy; artificial intelligence; cations; density functional theory; journals; materials; models; prediction; production costs; solar cells;     Show all 12 Subjects
Abstract:
... Double hybrid organic–inorganic perovskites (DHOIPs) with excellent optoelectronic properties and low production costs are promising in photovoltaic applications. However, DHOIPs still have not been investigated thoroughly, due to their structural complexities. In this work, an accelerated discovery of DHOIPs has been realized by combining machine learning (ML) techniques, high-throughput screenin ...
DOI:
10.1039/d1ta09911f

8. Chiral chromatography method screening strategies: Past, present and future

Author:
Abhijit Tarafder; Larry Miller
Source:
Journal of chromatography 2021 v.1638 pp. 461878
ISSN:
0021-9673
Subject:
screening,   etc   ; chromatography; journals; objectives; reaction kinetics; wills;     Show all 6 Subjects
Abstract:
... Method screening is an integral part of chromatographic method development for the separation of racemates. Due to the highly complex retention mechanism of a chiral stationary-phase, it is often difficult, if not impossible, to device predefined method-development steps that can be successfully applied to a wide group of molecules. The standard approach is to evaluate or screen a series of statio ...
DOI:
10.1016/j.chroma.2021.461878

9. Direct screening of a target-specific covalent binder: stringent regulation of warhead reactivity in a matchmaking environment

Author:
Yudai Tabuchi; Takahito Watanabe; Riku Katsuki; Yuji Ito; Masumi Taki
Source:
Chemical communications 2021 v.57 no.44 pp. 5378-5381
ISSN:
1364-548X
Subject:
screening,   etc   ; bacteriophages; chemical communication; peptide libraries; proteins;     Show all 5 Subjects
Abstract:
... A peptide-type covalent binder for a target protein was obtained by direct and stringent screening of a warhead-modified peptide library on the robust T7 phage. The aryl fluorosulfate (fosylate) warhead was activated only in a matchmaking microenvironment created between the target protein and an appropriate peptide during the reactivity/affinity-based co-selection process of extended phage displa ...
DOI:
10.1039/d1cc01773j

10. Drop-Casting Method to Screen Ruddlesden–Popper Perovskite Formulations for Use in Solar Cells

Author:
Chuantian Zuo; Andrew D. Scully; Mei Gao
Source:
ACS applied materials & interfaces 2021 v.13 no.47 pp. 56217-56225
ISSN:
1944-8252
Subject:
screening,   etc   ; coatings; manufacturing; solar cells; spectroscopy; utilities;     Show all 6 Subjects
Abstract:
... Small-area metal–halide perovskite solar cells (PSCs) having power-conversion efficiencies (PCEs) of greater than 25% can be prepared by using a spin-coated perovskite layer, but this technique is not readily transferrable to large-scale manufacturing. Drop-casting is a simple alternative method for film formation that is more closely aligned to industry-relevant coating processes. In the present ...
DOI:
10.1021/acsami.1c17475

11. Reply to the Comment on “Phase transitions, screening and dielectric response of CsPbBr₃” by Š. Svirskas, S. Balčiūnas, M. Šimėnas, G. Usevičius, M. Kinka, M. Velička, D. Kubicki, M. E. Castillo, A. Karabanov, V. V. Shvartsman, M. R. Soares, V. Šablinskas, A. N. Salak, D. C. Lupascu and J. Banys, J. Mater. Chem. A, 2020, 8, 14015

Author:
Šarūnas Svirskas; Sergejus Balčiūnas; Mantas Šimėnas; Gediminas Usevičius; Martynas Kinka; Martynas Velička; Dominik Kubicki; Marianela Escobar Castillo; Andrei Karabanov; Vladimir V. Shvartsman; Maria de Rosário Soares; Valdas Šablinskas; Andrei N. Salak; Doru C. Lupascu; Jūras Banys
Source:
Journal of materials chemistry A 2021 v.9 no.18 pp. 11453-11455
ISSN:
2050-7496
Subject:
screening,   etc   ; crystals; dielectrics; journals; materials; phase transition; temperature;     Show all 7 Subjects
Abstract:
... In this reply, we address the concerns that were raised about our paper on CsPbBr₃ single crystals. M. Szafrański criticized the dielectric and DSC data in our original paper claiming that they were affected by the experimental artefacts or poor quality of the investigated single crystals, as his DSC and dielectric data did not show any low temperature anomalies in CsPbBr₃. We argue in this reply ...
DOI:
10.1039/d1ta02123k

12. In situ observation of heterogeneous catalytic organic reactions via aggregation-induced emission luminogens

Author:
Jinzhao Ji; Jinying Yuan; Yen Wei
Source:
Chemical communications 2022 v.58 no.10 pp. 1601-1604
ISSN:
1364-548X
Subject:
screening,   etc   ; catalysts; catalytic activity; chemical communication; emissions; models; montmorillonite;     Show all 7 Subjects
Abstract:
... Herein, we demonstrated for the first time that customized aggregation-induced emission luminogens can be utilized to directly visualize heterogeneous catalytic organic reactions, which further enables catalyst screening. We used the retro-Diels–Alder reaction as a model reaction for illustration, and identified montmorillonite K10 as the best catalyst in our catalyst screening. ...
DOI:
10.1039/d1cc06706k

13. A GGA + U investigation into the effects of cations on the electromagnetic properties of transition metal spinels

Author:
Chunyu Li; Peng Li; Leyun Li; Dingjia Wang; Xingfa Gao; Xuejiao J. Gao
Source:
RSC advances 2021 v.11 no.35 pp. 21851-21856
ISSN:
2046-2069
Subject:
screening,   etc   ; catalysts; cations; oxides; physicochemical properties; transition elements; wills;     Show all 7 Subjects
Abstract:
... Spinel oxides are promising low-cost catalysts with manifold and controllable physicochemical properties. Trial and error strategies cannot achieve the effective screening of high-performance spinel catalysts. Therefore, unraveling the structure–performance relationship is the foundation for their rational design. Herein, the effects of cations in tetrahedral and octahedral sites on the electronic ...
DOI:
10.1039/d1ra03621a

14. Addressing barriers to the conduct and application of research in complementary and alternative medicine: a scoping review

Author:
Yasamin Veziari; Saravana Kumar; Matthew Leach
Source:
BMC complementary medicine and therapies 2021 v.21 no.1 pp. 201
ISSN:
2662-7671
Subject:
screening,   etc   ; alternative medicine; educational methods; funding; libraries; stakeholders; wills;     Show all 7 Subjects
Abstract:
... BACKGROUND: Over the past few decades, the popularity of complementary and alternative medicine (CAM) has grown considerably and along with it, scrutiny regarding its evidence base. While this is to be expected, and is in line with other health disciplines, research in CAM is confronted by numerous obstacles. This scoping review aims to identify and report the strategies implemented to address bar ...
DOI:
10.1186/s12906-021-03371-6

15. Implicit action prediction constrains observed biological action reconstruction

Author:
Amanda Mara de Assis Chagas; Isabella Alves de Faria; Ghislain Saunier; Ruben E. Bittencourt-Navarrete; Anaelli Aparecida Nogueira-Campos
Source:
Heliyon 2021 v.7 no.2 pp. e06189
ISSN:
2405-8440
Subject:
screening,   etc   ; bottles; bottling; hands; humans; motors; prediction; volunteerism; volunteers;     Show all 9 Subjects
Abstract:
... Voluntary movements include a predictive control of the sensory-motor consequences of executed or observed actions. The motor system predicts further steps of actions relying on its pure observation. This study seeks to disclose the interference of an implicit motor prediction effect during actions reconstruction. Videos of human actions directed to objects were presented to volunteers. Subsequent ...
DOI:
10.1016/j.heliyon.2021.e06189

16. Transmissible cancers in mammals and bivalves: How many examples are there?: Predictions indicate widespread occurrence

Author:
Antoine M. Dujon; Georgina Bramwell; Benjamin Roche; Frédéric Thomas; Beata Ujvari
Source:
BioEssays 2021 v.43 no.3 pp. e2000222
ISSN:
0265-9247
Subject:
screening,   etc   ; Bivalvia; equations; forces; hosts; mammals; neoplasms; prediction; sheds;     Show all 9 Subjects
Abstract:
... Transmissible cancers are elusive and understudied parasitic life forms caused by malignant clonal cells (nine lineages are known so far). They emerge by completing sequential steps that include breaking cell cooperation, evade anti‐cancer defences and shedding cells to infect new hosts. Transmissible cancers impair host fitness, and their importance as selective force is likely largely underestim ...
DOI:
10.1002/bies.202000222

17. Probabilistic energy flow calculation for regional integrated energy system considering cross-system failures

Author:
Hang Li; Kai Hou; Xiandong Xu; Hongjie Jia; Lewei Zhu; Yunfei Mu
Source:
Applied energy 2022 v.308 pp. 118326
ISSN:
0306-2619
Subject:
screening,   etc   ; couplings; crossing; energy flow; systems analysis; testing; wills;     Show all 7 Subjects
Abstract:
... With the increasing coupling among multiple energy systems, component failure of one system may spread to other systems, which results in cross-system failures that will remarkably affect the operation state of RIES. In this regard, this paper proposes a probabilistic energy flow calculation approach for regional integrated energy system (RIES), taking into account those cross-system failures (CSF ...
DOI:
10.1016/j.apenergy.2021.118326

18. Automated, flexible and versatile manipulation of nanoliter-to-picoliter droplets based on sequential operation droplet array technique

Author:
Zhi Dong; Qun Fang
Source:
Trends in analytical chemistry 2020 v.124 pp. 115812
ISSN:
0165-9936
Subject:
high-throughput screening methods; screening,   etc   ; automation; droplets; microfluidic technology;     Show all 5 Subjects
Abstract:
... Droplet microfluidic technology has emerged as a powerful tool for biological analysis and screening. Currently, there is an urgent need to develop a versatile microfluidic droplet technique that can be adapted to different applications and widely adopted in routine laboratories. In this review, we introduce automated, flexible and versatile manipulation systems for nanoliter-to-picoliter droplets ...
DOI:
10.1016/j.trac.2020.115812

19. Effective aperture tuning of a zeolitic-imidazole framework CdIF-1 by controlled thermal amorphization

Author:
Sunghwan Park; Hae-Kwon Jeong
Source:
Journal of materials chemistry A 2022 v.10 no.9 pp. 4992-4998
ISSN:
2050-7496
Subject:
screening,   etc   ; adsorption; exhibitions; gases; journals; materials; separation; sieves; sieving; temperature;     Show all 10 Subjects
Abstract:
... Sodalite zeolitic-imidazole frameworks (ZIFs) show great potential due to their effective aperture sizes suitable for small gas separations. Numerous efforts have, therefore, been made in tuning their effective aperture sizes to control and enhance their molecular sieving properties. Herein, we present a new strategy to finely tune the effective aperture size of CdIF-1, a cadmium-substituted ZIF-8 ...
DOI:
10.1039/d1ta10706b

20. An Ensemble Learning Platform for the Large-Scale Exploration of New Double Perovskites

Author:
Zhilong Wang; Yanqiang Han; Xirong Lin; Junfei Cai; Sicheng Wu; Jinjin Li
Source:
ACS applied materials & interfaces 2021 v.14 no.1 pp. 717-725
ISSN:
1944-8252
Subject:
screening,   etc   ; exhibitions; mass; materials; photovoltaic cells; shortenings; thermal stability; wills;     Show all 8 Subjects
Abstract:
... Lead-free double perovskites are regarded as stable and green optoelectronic alternatives to single perovskites, but may exhibit indirect band gaps and high effective masses, thus limiting their maximum photovoltaic efficiency. Considering that the trial-and-error experimental and computational approaches cannot quickly identify ideal candidates, we propose an ensemble learning workflow to screen ...
DOI:
10.1021/acsami.1c18477