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1. Alisma genus: Phytochemical constituents, biosynthesis, and biological activities

Author:
Feng, Lei; Liu, Tian‐Tian; Huo, Xiao‐Kui; Tian, Xiang‐Ge; Wang, Chao; Lv, Xia; Ning, Jing; Zhao, Wen‐Yu; Zhang, Bao‐Jing; Sun, Cheng‐Peng; Ma, Xiao‐Chi
Source:
Phytotherapy research 2021 v.35 no.4 pp. 1872-1886
ISSN:
0951-418X
Subject:
secondary metabolites,   etc   ; biosynthesis; phytochemicals; phytotherapy; research;     Show all 5 Subjects
Abstract:
... The genus Alisma contains 11 species distributed worldwide, of which at least two species (A. orientale [Sam.] Juzep. and A. plantago‐aquatica Linn.) have been used as common herbal medicines. Secondary metabolites obtained from the genus Alisma are considered to be the material basis for the various biological functions and medicinal applications. In this review, we mainly focused on the recent i ...
DOI:
10.1002/ptr.6933

2. Bioactive flavonoids from Knema elegans

Author:
Zhang, You-Xi; Lu, Zhao; Wu, Wen-Chao; Chen, Ye-Gao; Zhan, Rui
Source:
Phytochemistry letters 2021 v.42 pp. 121-124
ISSN:
1874-3900
Subject:
secondary metabolites,   etc   ; branches; flavonoids; leaves; models;     Show all 5 Subjects
Abstract:
... The twigs and leaves of Knema elegans were analyzed to detect bioactive secondary metabolites. Thirteen flavonoids, including two new compounds (1 and 2), were isolated and characterized. Compounds 1-3, 12, and 13 showed moderate inhibitory effects against α-glycosidase, with IC₅₀ values ranging from 11.80 to 15.77 μM. Moreover, compounds 1, 2, 4, 7, 11, and 13 exhibited radical scavenging capacit ...
DOI:
10.1016/j.phytol.2020.12.005

3. Review of Membrane Separation Models and Technologies: Processing Complex Food-Based Biomolecular Fractions

Author:
Rajendran, Subin R. C. K.; Mason, Beth; Doucette, Alan A.
Source:
Food and bioprocess technology 2021 v.14 no.3 pp. 415-428
ISSN:
1935-5130
Subject:
secondary metabolites,   etc   ; bioprocessing; food industry; peptides; polysaccharides;     Show all 5 Subjects
Abstract:
... There is growing interest in the food industry to develop approaches for large-scale production of bioactive molecules through continuous downstream processing, especially from sustainable sources. Membrane-based separation technologies have the potential to reduce production costs while incorporating versatile multiproduct processing capabilities. This review describes advances in membrane techno ...
DOI:
10.1007/s11947-020-02559-x

4. Synthetic efforts on the road to marine natural products bearing 4-O-2,3,4,6-tetrasubstituted THPs: an update

Author:
Fariña-Ramos, Marta; García, Celina; Martín, Víctor S.; Álvarez-Méndez, Sergio J.
Source:
RSC advances 2021 v.11 no.10 pp. 5832-5858
ISSN:
2046-2069
Subject:
secondary metabolites,   etc   ; biosynthesis; carbon; macrolides; oxygen;     Show all 5 Subjects
Abstract:
... Scientific literature is inundated with secondary metabolites from marine sources. In this ocean of natural products, the presence of recurring patterns has traditionally led scientists to unravel the biosynthetic mechanisms that naturally yield these products, as well as to imitate Nature to prepare them in the laboratory, especially when promising bioactivities and stimulating molecular architec ...
DOI:
10.1039/d0ra10755g

5. Extraction of phenolic compounds: A review

Author:
Alara, Oluwaseun Ruth; Abdurahman, Nour Hamid; Ukaegbu, Chinonso Ishamel
Source:
Current research in food science 2021 v.4 pp. 200-214
ISSN:
2665-9271
Subject:
secondary metabolites,   etc   ; food science; glycosides; research;     Show all 4 Subjects
Abstract:
... Phenolic compounds are parts of secondary metabolites mostly found in plant species with enormous structural diversities. They can exist as glycosides or aglycones; matrix or free-bound compounds; and comprising mostly polymerized or monomer structures. Additionally, these compounds are not universally dispensed within plants with varied stability. This has contributed to challenging extraction pr ...
DOI:
10.1016/j.crfs.2021.03.011

6. Multi-omics analysis of Ginkgo biloba preliminarily reveals the co-regulatory mechanism between stilbenes and flavonoids

Author:
He, Bing; Liu, Hailin; Han, Xin; Cui, Peng; Xu, Li-an
Source:
Industrial crops and products 2021 v.167 pp. 113434
ISSN:
0926-6690
Subject:
secondary metabolites,   etc   ; Ginkgo biloba; flavonoids; landscapes; metabolome; multiomics; stilbenes; transcriptome;     Show all 8 Subjects
Abstract:
... As an ancient relict species, Ginkgo biloba has not only unique evolutionary status, but also outstanding medicinal value. Flavonoids, as the main medicinal components of G. biloba leaves, are widely involved with the molecular mechanism of their synthesis and regulation, an aspect which needs to be further studied. Besides this, there is still a lack of global systematic analyses of G. biloba sec ...
DOI:
10.1016/j.indcrop.2021.113434

7. Role of bioactive metabolites from Acremonium camptosporum associated with the marine sponge Aplysina fulva

Author:
Martins, Thamires; Schinke, Claudia; Queiroz, Sonia C.N.; de C Braga, Patrícia A.; Silva, Fábio S.P.; Melo, Itamar S.; Reyes, Felix G.R.
Source:
Chemosphere 2021 v.274 pp. 129753
ISSN:
0045-6535
Subject:
secondary metabolites,   etc   ; Acremonium; Porifera; cytotoxicity; fungi; predation; Brazil;     Show all 7 Subjects
Abstract:
... Acremonium camptosporum, a fungus associated with the marine sponge Aplysina fulva, was collected from the isolated mid-Atlantic Saint Peter and Saint Paul Archipelago, Brazil, and was found to produce secondary metabolites that displayed antibacterial activities. Mass spectra data obtained by UPLC-ESI-MS/MS analyses of these extracts were compared to several databases and revealed the presence of ...
DOI:
10.1016/j.chemosphere.2021.129753

8. The effects of different potato dextrose agar media on secondary metabolite production in Fusarium

Author:
Westphal, Klaus Ringsborg; Heidelbach, Søren; Zeuner, Emil Juel; Riisgaard-Jensen, Marie; Nielsen, Morten Eneberg; Vestergaard, Sofie Zacho; Bekker, Nicolai Sundgaard; Skovmark, Jesper; Olesen, Christian Kjær; Thomsen, Katrine Hartmann; Niebling, Sara Kramer; Sørensen, Jens Laurids; Sondergaard, Teis Esben
Source:
International journal of food microbiology 2021 v.347 pp. 109171
ISSN:
0168-1605
Subject:
secondary metabolites,   etc   ; culture media; food microbiology; fungal growth;     Show all 4 Subjects
Abstract:
... Potatoes contain several nutrients essential for fungal growth, making them an excellent component of media such as the popular Potato Dextrose Agar (PDA) medium. Commercially, PDA is available from multiple retailers offering virtually the same product. These media, however, could contain small differences in composition of nutrients affecting the expression of secondary metabolites. This study a ...
DOI:
10.1016/j.ijfoodmicro.2021.109171

9. Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces

Author:
Li, Shanshan; Li, Zilong; Pang, Shen; Xiang, Wensheng; Wang, Weishan
Source:
Current opinion in biotechnology 2021 v.69 pp. 26-34
ISSN:
0958-1669
Subject:
secondary metabolites,   etc   ; Streptomyces; biosynthesis; biotechnology; drugs; fermentation; medicine; polyketides;     Show all 8 Subjects
Abstract:
... The widely used polyketide pharmaceuticals in medicine and agriculture are mainly produced by Streptomyces species. These compounds, as secondary metabolites, are not involved in essential cellular processes and are usually produced during the stationary phase of fermentation. Consequently, their yields and productivities are often low and frequently limited by the availability of the precursors. ...
DOI:
10.1016/j.copbio.2020.11.006

10. Molecular and metabolomic interventions for identifying potential bioactive molecules to mitigate diseases and their impacts on crop plants

Author:
Choudhary, Pooja; Aggarwal, Pooja Rani; Rana, Sumi; Nagarathnam, Radhakrishnan; Muthamilarasan, Mehanathan
Source:
Physiological and molecular plant pathology 2021 v.114 pp. 101624
ISSN:
0885-5765
Subject:
secondary metabolites,   etc   ; disease progression; disease severity; immunity; metabolomics; plant pathology;     Show all 6 Subjects
Abstract:
... The multifaceted defense response of plants involves bioactive natural compounds that recognize, intervene, and neutralize the incoming pathogens. Plant secondary metabolites play roles at different stages of infection and disease progression. Studies have shown the synthesis of specific metabolites to confer resistance or tolerance depending on disease severity and other related factors. However, ...
DOI:
10.1016/j.pmpp.2021.101624

11. A review: Application of allelochemicals in water ecological restoration——algal inhibition

Author:
Li, Benhang; Yin, Yijun; Kang, Longfei; Feng, Li; Liu, Yongze; Du, Ziwen; Tian, Yajun; Zhang, Liqiu
Source:
Chemosphere 2021 v.267 pp. 128869
ISSN:
0045-6535
Subject:
secondary metabolites,   etc   ; allelochemicals; biocompatibility; biodegradability; ecological restoration; microparticles; poisonous algae;     Show all 7 Subjects
Abstract:
... Problems caused by harmful algal blooms have attracted worldwide attention due to their severe harm to aquatic ecosystems, prompting researchers to study applicable measures to inhibit the growth of algae. Allelochemicals, as secondary metabolites secreted by plants, have excellent biocompatibility, biodegradability, obvious algal inhibiting effect and little ecological harm, and have promising ap ...
DOI:
10.1016/j.chemosphere.2020.128869

12. Chemical constituents from Laggera pterodonta

Author:
Xie, Yan-Qing; Fan, Wei-Tong; Chen, Xuan-Qin; Li, Rong-Tao; Zhang, Zhi-Jun
Source:
Biochemical systematics and ecology 2021 v.94 pp. 104222
ISSN:
0305-1978
Subject:
secondary metabolites,   etc   ; Laggera; chemotaxonomy; ecology; flavonoids; lignans; pyrroles; sesquiterpenoids;     Show all 8 Subjects
Abstract:
... A phytochemical investigation on the aerial parts of Laggera pterodonta resulted in the isolation and identification of fourteen compounds, including six sesquiterpenoids (1–6), five flavonoids (7–11), one lignan (12), and two pyrrole alkaloids (13, 14). Among them, compounds 1–3, 7–9, and 11 are the characteristic class of secondary metabolites of L. pterodonta. Compounds 4 and 5 were firstly iso ...
DOI:
10.1016/j.bse.2020.104222

13. DiaNat-DB: a molecular database of antidiabetic compounds from medicinal plants

Author:
Madariaga-Mazón, Abraham; Naveja, José J.; Medina-Franco, José L.; Noriega-Colima, Karla O.; Martinez-Mayorga, Karina
Source:
RSC advances 2021 v.11 no.9 pp. 5172-5178
ISSN:
2046-2069
Subject:
secondary metabolites,   etc   ; databases; diabetes mellitus; drug development; glycemic effect;     Show all 5 Subjects
Abstract:
... Natural products are an invaluable source of molecules with a large variety of biological activities. Interest in natural products in drug discovery is documented in an increasing number of publications of bioactive secondary metabolites. Among those, medicinal plants are one of the most studied for this endeavor. An ever thriving area of opportunity within the field concerns the discovery of anti ...
DOI:
10.1039/d0ra10453a

14. Hypericum genus cosmeceutical application – A decade comprehensive review on its multifunctional biological properties

Author:
Silva, Ana Rita; Taofiq, Oludemi; Ferreira, Isabel C.F.R.; Barros, Lillian
Source:
Industrial crops and products 2021 v.159 pp. 113053
ISSN:
0926-6690
Subject:
secondary metabolites,   etc   ; chemical constituents of plants; cosmetics; enzymes; toxicology;     Show all 5 Subjects
Abstract:
... Hypericum is a genus of flowering plants and presents a nearly worldwide distribution. The relevance of its species is mainly based on the occurrence of specialised secondary metabolites exhibiting a wide range of pharmaceutical and cosmeceutical properties. The most well-reported species in the last decade is H. perforatum, together with its exceptional polycyclic polyprenylated acylphloroglucino ...
DOI:
10.1016/j.indcrop.2020.113053

15. Membrane transporters: the key drivers of transport of secondary metabolites in plants

Author:
Gani, Umar; Vishwakarma, Ram A.; Misra, Prashant
Source:
Plant cell reports 2021 v.40 no.1 pp. 1-18
ISSN:
0721-7714
Subject:
secondary metabolites,   etc   ; biosynthesis; cytotoxicity; extrusion; herbivores; toxic substances;     Show all 6 Subjects
Abstract:
... KEY MESSAGE: This review summarizes the recent updates in the area of transporters of plant secondary metabolites, including their applied aspects in metabolic engineering of economically important secondary metabolites. Plants have evolved biosynthetic pathways to produce structurally diverse secondary metabolites, which serve distinct functions, including defense against pathogens and herbivory, ...
DOI:
10.1007/s00299-020-02599-9

16. Mycotoxins in Beverages

Author:
González-Peñas, Elena
Source:
Beverages 2020 v.6 no.4
ISSN:
2306-5710
Subject:
secondary metabolites,   etc   ; humidity; mycotoxins; temperature;     Show all 4 Subjects
Abstract:
... Mycotoxins are secondary metabolites produced by fungi that contaminate raw materials such as cereals, fruits, dried fruits, coffee, and grapes when they have been produced or maintained in a temperature and/or humidity conditions that favor fungi growth [...] ...
DOI:
10.3390/beverages6040069

17. Promotion of Bacillus subtilis subsp. inaquosorum, Bacillus subtilis subsp. spizizenii and Bacillus subtilis subsp. stercoris to species status

Author:
Dunlap, Christopher A.; Bowman, Michael J.; Zeigler, Daniel R.
Source:
Antonie van Leeuwenhoek 2020 v.113 no.1 pp. 1-12
ISSN:
0003-6072
Subject:
secondary metabolites,   etc   ; chemotaxonomy; genomics; phenotype;     Show all 4 Subjects
Abstract:
... Bacillus subtilis currently encompasses four subspecies, Bacillus subtilis subsp. subtilis, Bacillus subtilis subsp. inaquosorum, Bacillus subtilis subsp. spizizenii and Bacillus subtilis subsp. stercoris. Several studies based on genomic comparisons have suggested these subspecies should be promoted to species status. Previously, one of the main reasons for leaving them as subspecies was the lack ...
DOI:
10.1007/s10482-019-01354-9

18. A source-sink model explains the difference in the metabolic mechanism of mechanical damage to young and senescing leaves in Catharanthus roseus

Author:
Chen, Qi; Lu, Xueyan; Guo, Xiaorui; Xu, Mingyuan; Tang, Zhonghua
Source:
BMC plant biology 2021 v.21 no.1 pp. 154
ISSN:
1471-2229
Subject:
secondary metabolites,   etc   ; Catharanthus roseus; death; energy; mechanical damage; metabolomics; models; phenolic compounds; tricarboxylic acid cycle;     Show all 9 Subjects
Abstract:
... BACKGROUND: Mechanical damage is an unavoidable threat to the growth and survival of plants. Although a wound to senescing (lower) leaves improves plant vitality, a wound to younger (upper) leaves often causes damage to or death of the whole plant. Source-sink models are often used to explain how plants respond to biotic or abiotic stresses. In this study, a source-sink model was used to explain t ...
DOI:
10.1186/s12870-021-02934-6

19. Effect of plant-based compounds on the antifungal and antiaflatoxigenic efficiency of strobilurins against Aspergillus flavus

Author:
Tian, Fei; Lee, Sang Yoo; Woo, So Young; Choi, Hwa Young; Park, Su Been; Chun, Hyang Sook
Source:
Journal of hazardous materials 2021 v.415 pp. 125663
ISSN:
0304-3894
Subject:
secondary metabolites,   etc   ; Aspergillus flavus; aflatoxins; azoxystrobin; carcinogenicity; chemosensitization; food security; fungi; human health; mutagens; pyraclostrobin;     Show all 11 Subjects
Abstract:
... Aflatoxins are a group of carcinogenic and mutagenic fungal secondary metabolites that have threatened human health and global food security. Aflatoxin contamination can be controlled by applying fungicides, such as strobilurins. Although these compounds have been effective, they may be risky to the environment due to their wide usage. In this study, plant-based compounds were tested to promote th ...
DOI:
10.1016/j.jhazmat.2021.125663

20. Application of natural antimicrobials in food preservation: Recent views

Author:
El-Saber Batiha, Gaber; Hussein, Diaa E.; Algammal, Abdelazeem M.; George, Toyosi T.; Jeandet, Philippe; Al-Snafi, Ali Esmail; Tiwari, Achyut; Pagnossa, Jorge Pamplona; Lima, Clara Mariana; Thorat, Nanasaheb D.; Zahoor, Muhammad; El-Esawi, Mohamed; Dey, Abhijit; Alghamdi, Saad; Hetta, Helal F.; Cruz-Martins, Natália
Source:
Food control 2021 v.126 pp. 108066
ISSN:
0956-7135
Subject:
secondary metabolites,   etc   ; animals; anti-infective agents; consumer attitudes; food preservation; food safety; information; spoilage;     Show all 8 Subjects
Abstract:
... Consumer concern on the use of naturally-occurring antimicrobials from plants, microorganisms and animal sources continues to grow daily, mostly triggered by the increasing awareness about the risks associated with the use of synthetically manufactured additives and preservatives in the food industry.Natural compounds present in herbs- and spices-derived extracts, essential oils and other secondar ...
DOI:
10.1016/j.foodcont.2021.108066