PubAg

Main content area

You searched for: Subject "secondary metabolites" Remove constraint Subject: "secondary metabolites"
Start Over

Search

10,985  Search Results

« Previous | 1 - 20 of 10,985 |
Number of results to display per page

Search Results

1. Fungi: outstanding source of novel chemical scaffolds

Author:
Liu, Zhen; Zhao, Jing-Yi; Sun, Sen-Feng; Li, Yong; Liu, Yun-Bao
Source:
Journal of Asian natural products research 2020 v.22 no.2 pp. 99-120
ISSN:
1477-2213
Subject:
secondary metabolites,   etc   ; bioactive properties; endophytes; fungi;     Show all 4 Subjects
Abstract:
... A large number of remarkable studies on the secondary metabolites of fungi have been conducted in recent years. This review gives an overview of one hundred and sixty-seven molecules with novel skeletons and their bioactivities that have been reported in seventy-nine articles published from 2013 to 2017. Our statistical data showed that endophytic fungi and marine-derived fungi are the major sourc ...
DOI:
10.1080/10286020.2018.1488833

2. Fungal endophytes promote the accumulation of Amaryllidaceae alkaloids in Lycoris radiata

Author:
Zhou, Jiayu; Liu, Zhilin; Wang, Songfeng; Li, Jie; Li, Yikui; Chen, Wei‐Kang; Wang, Ren
Source:
Environmental microbiology 2020 v.22 no.4 pp. 1421-1434
ISSN:
1462-2912
Subject:
secondary metabolites,   etc   ; Lycoris radiata; alkaloids; drug development; endophytes; fungi;     Show all 6 Subjects
Abstract:
... Lycoris radiata is a main source of Amaryllidaceae alkaloids; however, the low content of these alkaloids in planta remains a limit to their pharmaceutical development and utilization. The accumulation of secondary metabolites can be enhanced in plants inoculated with fungal endophytes. In this study, we analysed the diversity of culturable fungal endophytes in different organs of L. radiata. Then ...
DOI:
10.1111/1462-2920.14958

3. MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product

Author:
Zhang, Fan; Wyche, Thomas P.; Zhu, Yanlong; Braun, Doug R.; Yan, Jia-Xuan; Chanana, Shaurya; Ge, Ying; Guzei, Ilia A.; Chevrette, Marc G.; Currie, Cameron R.; Thomas, Michael G.; Rajski, Scott R.; Bugni, Tim S.
Source:
Organic letters 2020 v.22 no.4 pp. 1275-1279
ISSN:
1523-7052
Subject:
secondary metabolites,   etc   ; Actinomadura; chemical reactions; moieties; organic compounds;     Show all 5 Subjects
Abstract:
... Forazoline A is a structurally complex PKS–NRPS hybrid produced by marine-derived Actinomadura sp. During the course of studies highlighting the application of IFS analysis as a powerful tool for natural products analysis, we were alerted to an earlier misinterpretation with respect to forazoline A structure elucidation. In particular, IFS reveals that forazoline A contains a thioketone moiety rar ...
DOI:
10.1021/acs.orglett.9b04535

4. Total Synthesis and Stereochemical Assignment of Penicitide A

Author:
Saha, Dhiman; Guchhait, Sandip; Goswami, Rajib Kumar
Source:
Organic letters 2020 v.22 no.2 pp. 745-749
ISSN:
1523-7052
Subject:
secondary metabolites,   etc   ; acetates; chemical reactions; chemical structure; olefin; stereochemistry; stereoselectivity;     Show all 7 Subjects
Abstract:
... Stereoselective total synthesis of marine secondary metabolite penicitide A has been accomplished for the first time following a convergent approach. The salient feature of this study includes Horner–Wadsworth–Emmons (HWE) olefination, Evans methylations, Crimmins acetate aldol reaction, and cross olefin metathesis. Our synthetic study established the stereochemistry of unassigned C-10 and C-12 ce ...
DOI:
10.1021/acs.orglett.9b04585

5. Assessment of secondary metabolite profile and quantification method development for Lupeol and Caffeic acid by HPTLC in Avicennia marina pneumatophore roots

Author:
Dawane, Vinars; Pathak, Bhawana
Source:
Biocatalysis and agricultural biotechnology 2020 v.26 pp. 101573
ISSN:
1878-8181
Subject:
secondary metabolites,   etc   ; Avicennia marina; bioactive compounds; biotechnology; caffeic acid; ingredients; lupeol; nanobiotechnology; pharmacognosy; phytochemicals; pneumatophores;     Show all 11 Subjects
Abstract:
... It has been strongly endorsed that mangroves should be considered as a treasured source for phytochemical ingredients with potential medicinal, environmental, agricultural, biotechnological and nanobiotechnological applications. They are able to produce lots of natural structures, significant enough for widely acceptable in today's scenario, to generate various commercial and valuable products. Th ...
DOI:
10.1016/j.bcab.2020.101573

6. Computational approaches to unravel the pathways and evolution of specialized metabolism

Author:
Mutwil, Marek
Source:
Current opinion in plant biology 2020 v.55 pp. 38-46
ISSN:
1369-5266
Subject:
secondary metabolites,   etc   ; abiotic stress; biochemical pathways; crops; evolution; herbivores; medicine; metabolism; nutrition; pathogens; plant physiology;     Show all 11 Subjects
Abstract:
... Specialized metabolites serve as a chemical arsenal that protects plants from abiotic stress, pathogens, and herbivores, and they are an essential component of our nutrition and medicine. Despite their importance, we are still at the beginning of unravelling biosynthetic pathways that produce these compounds, which is needed to produce more resilient and nutritious crops, expand our inventory of u ...
DOI:
10.1016/j.pbi.2020.01.007

7. Towards a functional understanding of the plant metabolome

Author:
Kosmacz, Monika; Sokołowska, Ewelina Maria; Bouzaa, Saad; Skirycz, Aleksandra
Source:
Current opinion in plant biology 2020 v.55 pp. 47-51
ISSN:
1369-5266
Subject:
secondary metabolites,   etc   ; amino acids; carotenoids; functional diversity; glucosinolates; metabolome; nucleotides; sugars;     Show all 8 Subjects
Abstract:
... Plants are true organic chemists—the chemical diversity of plant metabolomes goes hand in hand with functional diversity. New, often unexpected roles are being reported for both evolutionarily conserved and well-characterised central metabolites such as amino acids, nucleotides, and sugars, and for specialized/secondary metabolites such as carotenoids, glucosinolates, and terpenoids. Our review ai ...
DOI:
10.1016/j.pbi.2020.02.005

8. Enhancement of metabolic flux toward ε-poly-l-lysine biosynthesis by targeted inactivation of concomitant polyene macrolide biosynthesis in Streptomyces albulus

Author:
Yamanaka, Kazuya; Hamano, Yoshimitsu; Oikawa, Tadao
Source:
Journal of bioscience and bioengineering 2020 v.129 no.5 pp. 558-564
ISSN:
1389-1723
Subject:
secondary metabolites,   etc   ; Streptomyces albulus; biochemical pathways; biosynthesis; engineering; fermentation; food preservatives; multigene family; mutants; nystatin;     Show all 10 Subjects
Abstract:
... ε-Poly-l-lysine (ε-PL) produced as a secondary metabolite of Streptomyces albulus has long been used as a natural food preservative in a number of countries, including Japan, the United States, South Korea, and China. To date, numerous studies employing classical biotechnological approaches have been carried out to improve its productivity. Here we report a modern and rational genetic approach to ...
DOI:
10.1016/j.jbiosc.2019.12.002

9. Karrikins-induced accumulation of Salvianolic acid B is regulated by Jasmonic acid and hydrogen peroxide in Salvia miltiorrhiza

Author:
Sun, Hui; Xu, Zixin; Zhou, Jie; Guo, Lanping
Source:
South African journal of botany 2020 v.130 pp. 371-374
ISSN:
0254-6299
Subject:
secondary metabolites,   etc   ; Salvia miltiorrhiza; biosynthesis; catalase; hydrogen peroxide; jasmonic acid; karrikins; salvianolic acid;     Show all 8 Subjects
Abstract:
... The influence of smoke-isolated karrikins (KAR₁) on the production of endogenous signal molecules and secondary metabolite Salvianolic acid B (SAB) in Salvia miltiorrhiza has been studied. These results indicated that KAR₁ induced increase of the accumulation of jasmonic acid (JA) and hydrogen peroxide (H₂O₂) as well as SAB production. The contents of JA and H₂O₂ were increased by treatment of KAR ...
DOI:
10.1016/j.sajb.2020.01.021

10. Chemical profiling of herbarium samples of solanum (Solanaceae) using mass spectrometry

Author:
Mendes Resende, João Victor; de Sá, Najla M.D.; de Oliveira, Marcelo Trovó Lopes; Lopes, Rosana Conrado; Garrett, Rafael; Moreira Borges, Ricardo
Source:
Phytochemistry letters 2020 v.36 pp. 99-105
ISSN:
1874-3900
Subject:
secondary metabolites,   etc   ; Solanum argenteum; Solanum pseudoquina; herbaria; mass spectrometry; multivariate analysis; storage time;     Show all 7 Subjects
Abstract:
... Herbarium collections are broadly available for scientific evaluations but surprisingly few studies explored their rich chemical diversity. Considering the systematic organization and the storage conditions Herbarium collections are kept, we wonder if there are still secondary metabolites of interest after years of storage and how this data could be used to discriminate different species within th ...
DOI:
10.1016/j.phytol.2020.01.021

11. New tricks for old dogs: Two new macrocyclic trichothecene epimers and absolute configuration of 16-hydroxyverrucarin B

Author:
Kao, Diana; Flores-Bocanegra, Laura; Raja, Huzefa A.; Darveaux, Blaise A.; Pearce, Cedric J.; Oberlies, Nicholas H.
Source:
Phytochemistry 2020 v.172 pp. 112238
ISSN:
0031-9422
Subject:
secondary metabolites,   etc   ; bioactive properties; circular dichroism spectroscopy; dogs; esters; nuclear magnetic resonance spectroscopy; trichothecenes;     Show all 7 Subjects
Abstract:
... Two new compounds, 3′-epi-16-hydroxyverrucarin A and 3′-epiverrucarin X, have been isolated and identified, and the characterization data of a series of known trichothecenes have been refined. The interesting structure and potent biological activities of macrocyclic trichothecenes have been of interest to the scientific community for several decades. However, some of the characterization data for ...
DOI:
10.1016/j.phytochem.2019.112238
PubMed:
31931448
PubMed Central:
PMC7050405

12. Restricting mycotoxins without killing the producers: a new paradigm in nano-fungal interactions

Author:
Jesmin, Rubaiya; Chanda, Anindya
Source:
Applied microbiology and biotechnology 2020 v.104 no.7 pp. 2803-2813
ISSN:
0175-7598
Subject:
secondary metabolites,   etc   ; Aspergillus; antifungal agents; biosynthesis; ecotoxicology; fungi; humans; mycotoxins; nanoparticles; nanosilver; pathogens; theoretical models; toxicity;     Show all 13 Subjects
Abstract:
... Over the past several years, numerous studies have demonstrated the feasibility of using engineered nanoparticles as antifungals, especially against those fungal pathogens that produce mycotoxins and infect plants, animals, and humans. The high dosage of nanoparticles has been a concern in such antifungal applications due to the potential toxicological and ecotoxicological impacts. To address such ...
DOI:
10.1007/s00253-020-10373-w

13. Synthetic Protein Scaffolding at Biological Membranes

Author:
Behrendorff, James B.Y.H.; Borràs-Gas, Guillem; Pribil, Mathias
Source:
Trends in biotechnology 2020 v.38 no.4 pp. 432-446
ISSN:
0167-7799
Subject:
secondary metabolites,   etc   ; active sites; biochemical pathways; enzymes; membrane proteins; metabolic engineering; protein-protein interactions; scaffolding proteins;     Show all 8 Subjects
Abstract:
... Protein scaffolding is a natural phenomenon whereby proteins colocalize into macromolecular complexes via specific protein–protein interactions. In the case of metabolic enzymes, protein scaffolding drives metabolic flux through specific pathways by colocalizing enzyme active sites. Synthetic protein scaffolding is increasingly used as a mechanism to improve product specificity and yields in metab ...
DOI:
10.1016/j.tibtech.2019.10.009

14. Improvement of dioscorealide B production by elicitation in shoot cultures of Dioscorea membranacea Pierre ex Prain & Burkill

Author:
Jirakiattikul, Yaowapha; Rithichai, Panumart; Boonyeun, Thipsukon; Ruangnoo, Srisopa; Itharat, Arunporn
Source:
Physiology and molecular biology of plants 2020 v.26 no.3 pp. 585-591
ISSN:
0971-5894
Subject:
secondary metabolites,   etc   ; Dioscorea; benzyladenine; elicitors; exposure duration; jasmonic acid; liquids; salicylic acid; shoots;     Show all 9 Subjects
Abstract:
... Dioscorealide B is an important secondary metabolite isolated from Dioscorea membranacea Pierre ex Prain & Burkill. The effect on secondary metabolite content of different concentrations of two elicitors [jasmonic acid (JA) and salicylic acid (SA)], and of medium status and JA exposure period were investigated. In the JA and SA concentration experiment, 6-week-old shoots were cultured on MS medium ...
DOI:
10.1007/s12298-020-00762-w
PubMed:
32205932
PubMed Central:
PMC7078432

15. In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites

Author:
Bader, Chantal D.; Panter, Fabian; Müller, Rolf
Source:
Biotechnology advances 2020 v.39 pp. 107480
ISSN:
0734-9750
Subject:
secondary metabolites,   etc   ; Actinobacteria; Myxococcus xanthus; biosynthesis; genomics; metabolome; multigene family; myxobacteria; pathogens; prediction; prioritization;     Show all 11 Subjects
Abstract:
... In recognition of many microorganisms ability to produce a variety of secondary metabolites in parallel, Zeeck and coworkers introduced the term “OSMAC” (one strain many compounds) around the turn of the century. Since then, additional efforts focused on the systematic characterization of a single bacterial species ability to form multiple secondary metabolite scaffolds. With the beginning of the ...
DOI:
10.1016/j.biotechadv.2019.107480

16. Recent advances in photoelectrochemical biosensors for analysis of mycotoxins in food

Author:
Zhou, Qian; Tang, Dianping
Source:
Trends in analytical chemistry 2020 v.124 pp. 115814
ISSN:
0165-9936
Subject:
secondary metabolites,   etc   ; analytical methods; biosensors; electrochemistry; foods; fungi; human health; monitoring; mycotoxins; photochemistry; toxicity;     Show all 11 Subjects
Abstract:
... Mycotoxins, highly toxic secondary metabolites of fungus, have brought considerable threats to human health. It is of great significance to develop low-cost, rapid and efficient analytical methods for monitoring mycotoxins in foodstuffs. Photoelectrochemical (PEC) biosensors have been promising tools for mycotoxin detection thanks to their superior properties. Photoactive materials play important ...
DOI:
10.1016/j.trac.2020.115814

17. The effect of developmental and environmental factors on secondary metabolites in medicinal plants

Author:
Li, Yanqun; Kong, Dexin; Fu, Ying; Sussman, Michael R.; Wu, Hong
Source:
Plant physiology and biochemistry 2020 v.148 pp. 80-89
ISSN:
0981-9428
Subject:
secondary metabolites,   etc   ; environmental factors; enzymes; genes; genetic factors; medicinal plants; quality control; salinity; temperature;     Show all 9 Subjects
Abstract:
... Secondary metabolites (SMs) of medicinal plants are the material basis of their clinically curative effects. They are also important indicators for evaluating the quality of medicinal materials. However, the synthesis and accumulation of SMs are very complex, which are affected by many factors including internal developmental genetic circuits (regulated gene, enzyme) and by external environment fa ...
DOI:
10.1016/j.plaphy.2020.01.006

18. Endophytes producing podophyllotoxin from Podophyllum sp. and other plants: A review on isolation, extraction and bottlenecks

Author:
Biswas, D.; Biswas, P.; Nandy, S.; Mukherjee, A.; Pandey, D.K.; Dey, A.
Source:
South African journal of botany 2020
ISSN:
0254-6299
Subject:
secondary metabolites,   etc   ; Juniperus; Linum; Lithospermum; Podophyllum; endophytes; fermentation; fungi; medicinal plants; plant tissues; podophyllotoxin; surveys;     Show all 12 Subjects
Abstract:
... Investigation on the secondary metabolites of endophytic organisms colonized within plant body is now giving emphasis on the medicinal properties of those products aiming to the finding of new drug molecules. Podophyllotoxin is a non-alkaloid lignan of plant origin found in some species of Podophyllum and several other genera such as Sinopodophyllum, Juniperus, Dysosma, Diphylleia, Linum, Lithospe ...
DOI:
10.1016/j.sajb.2020.02.038

19. Allelopathic Plants: Models for Studying Plant–Interkingdom Interactions

Author:
Schandry, Niklas; Becker, Claude
Source:
Trends in plant science 2020 v.25 no.2 pp. 176-185
ISSN:
1360-1385
Subject:
secondary metabolites,   etc   ; allelochemicals; allelopathy; bacteria; benzoxazinoids; fungi; insects; models; plant health;     Show all 9 Subjects
Abstract:
... Allelopathy is a biochemical interaction between plants in which a donor plant releases secondary metabolites, allelochemicals, that are detrimental to the growth of its neighbours. Traditionally considered as bilateral interactions between two plants, allelopathy has recently emerged as a cross-kingdom process that can influence and be modulated by the other organisms in the plant’s environment. ...
DOI:
10.1016/j.tplants.2019.11.004

20. Antimicrobial secondary metabolites from agriculturally important bacteria as next-generation pesticides

Author:
Keswani, Chetan; Singh, Harikesh B.; García-Estrada, Carlos; Caradus, John; He, Ya-Wen; Mezaache-Aichour, Samia; Glare, Travis R.; Borriss, Rainer; Sansinenea, Estibaliz
Source:
Applied microbiology and biotechnology 2020 v.104 no.3 pp. 1013-1034
ISSN:
0175-7598
Subject:
secondary metabolites,   etc   ; bacteria; bioactive properties; biopesticides; crops; disease control; pathogens; pests; plant growth;     Show all 9 Subjects
Abstract:
... The whole organisms can be packaged as biopesticides, but secondary metabolites secreted by microorganisms can also have a wide range of biological activities that either protect the plant against pests and pathogens or act as plant growth promotors which can be beneficial for the agricultural crops. In this review, we have compiled information about the most important secondary metabolites of thr ...
DOI:
10.1007/s00253-019-10300-8