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1. Precursors and formation pathways of furfural in sugarcane juice during thermal treatment

Author:
Huimei Huang; Jiebo Chen; Mingfeng Zheng; Lulu Zhang; Hongfei Ji; Huajin Cao; Fengxia Dai; Lu Wang
Source:
Food chemistry 2023 v.402 pp. 134318
ISSN:
0308-8146
Subject:
serine,   etc   ; Maillard reaction; aromatic compounds; food chemistry; fructose; furfural; glucose; heat treatment; juice quality; sugarcane juice;     Show all 10 Subjects
Abstract:
... As a potent aromatic compound, furfural may have adverse effects on sugarcane juice quality. In this study, simplified sugarcane juice models containing glucose, fructose and amino acids were used to explore the potential precursors and formation pathways of furfural. The changes of precursors and intermediates involved in furfural formation were quantified. The results indicated that fructose con ...
DOI:
10.1016/j.foodchem.2022.134318

2. RPS6 transcriptional modulation in neural tissues of Nauphoeta cinerea during streptozotocin-associated sugar metabolism impairment.

Author:
Olawande C. Olagoke; Ana L.A. Segatto; Blessing A. Afolabi; Daniel Ardisson-Araujo; Michael Aschner; João B.T. Rocha
Source:
Comparative biochemistry and physiology 2023 v.263 pp. 110785
ISSN:
1096-4959
Subject:
non-specific serine/threonine protein kinase,   etc   ; Nauphoeta cinerea; biomedical research; brain; glucose; hyperglycemia; insects; metabolism; peptides; ribosomal proteins; sequence analysis; streptozotocin; transcription (genetics);     Show all 13 Subjects
Abstract:
... The use of insects to model molecular events that characterize degenerative conditions was originally met with scepticism. However, the discovery of insect insulin-like peptides in the 1970's and the demonstration of evolutionary conservation of insulin-related signalling from insects to mammals have highlighted the importance and reduced cost of insect models in biomedical research. Here, we expa ...
DOI:
10.1016/j.cbpb.2022.110785

3. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221

Author:
Jie Yang; Zi-Xuan Wang; Lei Fang; Tu-Shuai Li; Zhi-Hong Liu; Ying Pan; Ling-Dong Kong
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115688
ISSN:
0378-8741
Subject:
non-specific serine/threonine protein kinase,   etc   ; Atractylodes lancea; Magnolia officinalis; Oriental traditional medicine; Western blotting; adiponectin receptors; agonists; animal models; diet; fluorescent antibody technique; fructose; humans; insulin; insulin resistance; kidneys; liquid chromatography; pharmacology; rats; tandem mass spectrometry; therapeutics; thermosensitivity;     Show all 21 Subjects
Abstract:
... In traditional Chinese medicine, a long term of improper diet causes the Dampness and disturbs Zang-Fu's functions including Kidney deficiency. Atractylodes lancea (Atr) and Magnolia officinalis (Mag) as a famous herb pair are commonly used to transform Dampness, with kidney protection. To explore how Atr and Mag protected against insulin signaling impairment in glomerular podocytes induced by hig ...
DOI:
10.1016/j.jep.2022.115688

4. Cyclic guanidine containing amino acids that promote glucocerebrosidase

Author:
Zahraa S. Al-Taie; Barbara Bartholomew; Simon J. Coles; Daniel M. Evans; Jackie Hollinshead; Leigh F. Jones; Rolf Kraehenbuehl; Patrick J. Murphy; Robert J. Nash; Yana B. Penkova; Graham J. Tizzard
Source:
Tetrahedron 2022 pp. 132959
ISSN:
0040-4020
Subject:
serine,   etc   ; glucosylceramidase; guanidines;     Show all 3 Subjects
Abstract:
... Novel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from l-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase. ...
DOI:
10.1016/j.tet.2022.132959

5. Understanding HAIs: Ally proteins in the fight against cancer

Author:
Annika W. Nonboe; Zuzanna H. Bald; Lotte K. Vogel
Source:
FEBS journal 2022 v.289 no.12 pp. 3416-3418
ISSN:
1742-464X
Subject:
serine proteinases,   etc   ; epithelium;     Show all 2 Subject
Abstract:
... Understanding how HAI‐1 and HAI‐2 regulate the epithelial serine protease matriptase may hold the key to curing epithelial‐derived cancer. HAIs are serine protease inhibitors that inhibit matriptase and have a poorly understood effect on the presence of matriptase protein in cells. In this issue of The FEBS Journal, Yamashita et al. provide much‐needed new insights into this effect, describing it ...
DOI:
10.1111/febs.16399

6. Structural and functional studies of serine acetyltransferase isoform from Entamoeba histolytica reveals novel role of the C-terminal tail in loss of regulation from feedback inhibition

Author:
Sudhaker Dharavath; Khushboo Kumari; Sudhir Kumar; Samudrala Gourinath
Source:
International journal of biological macromolecules 2022 v.217 pp. 689-700
ISSN:
0141-8130
Subject:
serine; serine O-acetyltransferase,   etc   ; Entamoeba histolytica; acetylation; active sites; crystal structure; cysteine; sulfur;     Show all 8 Subjects
Abstract:
... Serine acetyltransferase (SAT) catalyzes the acetylation of l-serine in the first step of the two-step pathway to synthesize L-cysteine in bacteria, protozoans and plants. L-cysteine is known to be involved in feedback regulation of SAT. However, in E. histolytica, SAT exists in three isoforms where third isoform SAT3 is nearly insensitive to feedback inhibition. Here, we explored the previously u ...
DOI:
10.1016/j.ijbiomac.2022.07.095

7. The structure of cyanophycinase in complex with a cyanophycin degradation intermediate

Author:
Itai Sharon; Marcel Grogg; Donald Hilvert; T. Martin Schmeing
Source:
Biochimica et biophysica acta 2022 v.1866 no.11 pp. 130217
ISSN:
0304-4165
Subject:
serine; serine proteinases,   etc   ; active sites; aspartic acid; biopolymers; calorimetry; dipeptides; genetic code; metabolism; mutation; nitrogen;     Show all 11 Subjects
Abstract:
... Cyanophycinases are serine protease family enzymes which are required for the metabolism of cyanophycin, the natural polymer multi-L-arginyl-poly(L-aspartic acid). Cyanophycinases degrade cyanophycin to β-Asp-Arg dipeptides, which enables use of this important store of fixed nitrogen. We used genetic code expansion to incorporate diaminopropionic acid into cyanophycinase in place of the active sit ...
DOI:
10.1016/j.bbagen.2022.130217

8. Exploring the utility of nanoprotease as environmentally friendly benign laundry detergent fabric cleaner

Author:
Mukesh Tanwar; Mousumi Debnath; Sharmista Debnath; Priyanka Sharma; Anoop Mukhopadhay; Nipun Kakar; Seeram Ramakrishna
Source:
Journal of cleaner production 2022 v.334 pp. 130243
ISSN:
0959-6526
Subject:
serine; serine proteinases,   etc   ; agglutination; biocatalysis; chitosan; cost effectiveness; databases; denaturation; detergents; fabrics; laundry; metalloproteinases; pH; shelf life;     Show all 14 Subjects
Abstract:
... Extremophilic microbial proteases are well acknowledged as a valuable source of detergent additives. Both halophilic serine and metalloprotease are intriguing and industrially competent sources of salt-stable alkaline proteases, as per scientific literature. The public domain of the MEROPS peptidase database repository gave a clear understanding of enzyme classification and helped to classify the ...
DOI:
10.1016/j.jclepro.2021.130243

9. MLKs kinases phosphorylate the ESCRT component FREE1 to suppress abscisic acid sensitivity of seedling establishment

Author:
Hongbo Li; Juan Wei; Yanglan Liao; Xiaoling Cheng; Shuhong Yang; Xiaohong Zhuang; Zhonghui Zhang; Wenjin Shen; Caiji Gao
Source:
Plant, cell and environment 2022 v.45 no.7 pp. 2004-2018
ISSN:
0140-7791
Subject:
non-specific serine/threonine protein kinase; serine,   etc   ; abscisic acid; environment; mutation; phosphorylation; plant establishment; plant growth; ubiquitination;     Show all 9 Subjects
Abstract:
... The FYVE domain protein required for endosomal sorting 1 (FREE1), which was previously identified as a plant‐specific component of the endosomal sorting complex required for transport machinery, plays an essential role in endosomal trafficking. Moreover, FREE1 also functions as an important negative regulator in abscisic acid (ABA) signalling. Multiple phosphorylations and ubiquitination sites hav ...
DOI:
10.1111/pce.14336

10. 2.1 Å crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1)

Author:
Cory L. Brooks; David A. Ostrov; Nicholas C. Schumann; Schuchi Kakkad; Danmeng Li; Karla Peña; Brady Paul Williams; Nathan E. Goldfarb
Source:
Biochemical and biophysical research communications 2022 v.630 pp. 57-63
ISSN:
0006-291X
Subject:
serine; serine proteinases,   etc   ; Mycobacterium tuberculosis; active sites; crystal structure; drug design; drugs; fluorides; lipids; pathogenesis; proteinase inhibitors; research; therapeutics;     Show all 13 Subjects
Abstract:
... The 2.6 Å crystal structure of the apo form of Hip1 (hydrolase important for pathogenesis) has been previously reported. However, very little is known about the active site architecture of this M. tuberculosis (Mtb), serine hydrolase drug target. To begin mapping the active site of Hip1, we cocrystallized Hip1 with the irreversible serine protease inhibitor, 4-(2-aminoethyl)-benzenesulfonylfluorid ...
DOI:
10.1016/j.bbrc.2022.09.021

11. Interference of p53:Twist1 interaction through competing nanobodies

Author:
Serena D'Agostino; Elisa Mazzega; Katja Praček; Sara Piccinin; Flavia Pivetta; Michela Armellin; Sara Fortuna; Roberta Maestro; Ario de Marco
Source:
International journal of biological macromolecules 2022 v.194 pp. 24-31
ISSN:
0141-8130
Subject:
serine,   etc   ; cell viability; humans; llamas; phosphorylation; therapeutics;     Show all 6 Subjects
Abstract:
... Twist1 promote the bypass of p53 response by interacting with p53 and facilitating its MDM2-mediated degradation. We reasoned that reagents able to interfere with the p53:Twist1 complex might alleviate Twist1 inhibitory effect over p53, thus representing potential therapeutic tools in p53 wild type tumors. From a pre-immune library of llama nanobodies (VHH), we isolated binders targeting the p53 C ...
DOI:
10.1016/j.ijbiomac.2021.11.160

12. Free d-Amino Acids in Salivary Gland in Rat

Author:
Masanobu Yoshikawa; Takugi Kan; Kosuke Shirose; Mariko Watanabe; Mitsumasa Matsuda; Kenji Ito; Mitsuru Kawaguchi
Source:
Biology 2022 v.11 no.3 pp. -
ISSN:
2079-7737
Subject:
serine; serine racemase,   etc   ; D-amino-acid oxidase; D-aspartate oxidase; aspartic acid; catabolism; cerebral cortex; deamination; enantiomers; protein synthesis; rats; saliva;     Show all 12 Subjects
Abstract:
... Free d-amino acids, which are enantiomers of l-amino acids, are found in mammals, including humans, and play an important role in a range of physiological functions in the central nervous system and peripheral tissues. Several d-amino acids have been observed in saliva, but their origin and the enzymes involved in their metabolism and catabolism remain to be clarified. In the present study, large ...
DOI:
10.3390/biology11030390

13. Quantification of the pro-form of human complement component factor D (adipsin)

Author:
Maiken Lumby Henriksen; Christian Nielsen; Dennis Pedersen; Gregers Rom Andersen; Steffen Thiel; Yaseelan Palarasah; Soren Werner Karlskov Hansen
Source:
Journal of immunological methods 2022 v.507 pp. 113295
ISSN:
0022-1759
Subject:
serine proteinases,   etc   ; adipocytes; blood serum; complement; humans; lectins;     Show all 6 Subjects
Abstract:
... Factor D (also known as adipsin) is a serine protease and part of the complement system, involved in innate immune responses and effector functions of antibodies. Factor D cleaves factor B complexed with C3b, leading to the C3 convertase C3bBb. This C3 convertase is central in the alternative activation pathway and the amplification loop, which amplifies the two other complement activation pathway ...
DOI:
10.1016/j.jim.2022.113295

14. Stereoselective α-Deuteration of Serine, Cysteine, Selenocysteine, and 2,3-Diaminopropanoic Acid Derivatives

Author:
Claudio D. Navo; Paula Oroz; Nuria Mazo; Marina Blanco; Jesús M. Peregrina; Gonzalo Jiménez-Osés
Source:
Organic letters 2022 v.24 no.37 pp. 6810-6815
ISSN:
1523-7052
Subject:
serine,   etc   ; cysteine; deprotonation; diastereoselectivity; drugs; enantiomers; selenocysteine; thiols;     Show all 8 Subjects
Abstract:
... Efficient methodologies for synthesizing enantiopure α-deuterated derivatives of serine, cysteine, selenocysteine, and 2,3-diaminopropanoic acid have been developed. H/D exchange was achieved by deprotonation of a chiral bicyclic serine equivalent followed by selective deuteration. Additionally, diastereoselective additions of thiols, selenols, and amines to a chiral bicyclic dehydroalanine in deu ...
DOI:
10.1021/acs.orglett.2c02715

15. Glycine and serine markedly eliminate methylglyoxal in the presence of formaldehyde via the formation of imidazole salts

Author:
Jiaman Hu; Kaiyu Jiang; Caihuan Huang; Jie Zheng; Hua Zhou; Juanying Ou; Shiyi Ou
Source:
Food chemistry 2022 v.369 pp. 130952
ISSN:
0308-8146
Subject:
serine,   etc   ; cytotoxicity; food chemistry; formaldehyde; imidazole; pH; potatoes;     Show all 7 Subjects
Abstract:
... l-glycine and l-serine are the building blocks of proteins and exhibit various biological activities. This work found that l-glycine and l-serine show low scavenging capacity for methylglyoxal at moderate conditions (pH 7.0, 37 °C). However, they efficiently eliminate methylglyoxal and formaldehyde when the two aldehydes co-exist, via generation of imidazole salt, a compound formed by one molecule ...
DOI:
10.1016/j.foodchem.2021.130952

16. The ORF45 Protein of Kaposi’s Sarcoma-Associated Herpesvirus and Its Critical Role in the Viral Life Cycle

Author:
Natalie Atyeo; Bernadett Papp
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
non-specific serine/threonine protein kinase,   etc   ; capsid; interferons;     Show all 3 Subjects
Abstract:
... Kaposi’s sarcoma-associated herpesvirus (KSHV) protein ORF45 is a virion-associated tegument protein that is unique to the gammaherpesvirus family. Generation of KSHV ORF45-knockout mutants and their subsequent functional analyses have permitted a better understanding of ORF45 and its context-specific and vital role in the KSHV lytic cycle. ORF45 is a multifaceted protein that promotes infection a ...
DOI:
10.3390/v14092010

17. The novel human HtrA2 ortholog in zebrafish: New molecular insight and challenges into the imbalance of homeostasis

Author:
Min-Kyung Nam; Jeong-Mi Moon; Goo-Young Kim; Sung Min Kim; Hyangshuk Rhim
Source:
Gene 2022 v.819 pp. 146263
ISSN:
0378-1119
Subject:
serine; serine proteinases,   etc   ; DNA; Danio rerio; caspases; cell death; computer simulation; cytosol; death; genes; homeostasis; humans; mitochondria; quality control; sequence analysis; temperature; therapeutics;     Show all 17 Subjects
Abstract:
... High temperature requirement A2 (HtrA2) contributes to regulating mitochondrial quality control and maintaining the balance between the death and survival of cells and living organisms. However, the molecular mechanism of HtrA2 in physiological and pathophysiological processes remains unclear. HtrA2 exhibits multifaceted characteristics according to the expression levels and acts opposite function ...
DOI:
10.1016/j.gene.2022.146263

18. Clathriketal, a new tricyclic spiroketal compound from marine sponge Clathria prolifera attenuates serine exopeptidase dipeptidyl peptidase-IV

Author:
Prima Francis; Kajal Chakraborty
Source:
Natural product research 2022 v.36 no.12 pp. 3069-3077
ISSN:
1478-6427
Subject:
serine; serine proteinases,   etc   ; Porifera; alpha-amylase; antioxidants; dipeptidyl-peptidase IV; energy; glycemic effect; propionic acid; research; solvents; spectroscopy; structure-activity relationships; surface area; topology;     Show all 15 Subjects
Abstract:
... An undescribed tricyclic spiroketal compound clathriketal was purified from the solvent extract of the Microcionidae sponge Clathria prolifera, and was characterised as 7-(hydroxymethyl)-13-methoxy-3,11-dimethyl-4-oxo-octahydrospiro[chromene-9,13-pyran]-11-yl propionate by spectroscopic experiments. Clathriketal exhibited significant anti-hyperglycemic property by attenuating serine protease dipep ...
DOI:
10.1080/14786419.2021.1956491

19. The role of endogenous serine proteinase on disintegration of collagen fibers from grass carp (Ctenopharyngodon idellus)

Author:
Jiandong Shen; Wei Zhang; Pei Gao; Yanshun Xu; Wenshui Xia
Source:
Lebensmittel-Wissenschaft + Technologie 2022 v.156 pp. 113003
ISSN:
0023-6438
Subject:
serine; serine proteinases,   etc   ; Ctenopharyngodon idella; Fourier transform infrared spectroscopy; ammonium sulfate; chemical analysis; collagen; digestion; electrophoresis; fish; gelatin; glycosaminoglycans; hydroxyproline; muscles; proteoglycans; thermal stability;     Show all 16 Subjects
Abstract:
... Softening, causing by the degradation of collagen, leads to serious quality deterioration of fish fillets during post-mortem storage. In order to study the role of endogenous enzymes in softening of fish muscle, collagen fibers from grass carp (Ctenopharyngodon idellus) were degraded by serine proteinase. The structural and biochemical changes of collagen fibers with serine proteinase digestion we ...
DOI:
10.1016/j.lwt.2021.113003

20. A general chemical principle for creating closure-stabilizing integrin inhibitors

Author:
Fu-Yang Lin; Jing Li; Yonghua Xie; Jianghai Zhu; Thi Thu Huong Nguyen; Yonghui Zhang; Jieqing Zhu; Timothy A. Springer
Source:
Cell 2022 v.185 no.19 pp. 3533-3550.e27
ISSN:
0092-8674
Subject:
serine,   etc   ; adhesion; drug design; drugs; hydrogen; integrins; nitrogen; therapeutics;     Show all 8 Subjects
Abstract:
... Integrins are validated drug targets with six approved therapeutics. However, small-molecule inhibitors to three integrins failed in late-stage clinical trials for chronic indications. Such unfavorable outcomes may in part be caused by partial agonism, i.e., the stabilization of the high-affinity, extended-open integrin conformation. Here, we show that the failed, small-molecule inhibitors of inte ...
DOI:
10.1016/j.cell.2022.08.008