PubAg

Main content area

You searched for: Subject "serine" Remove constraint Subject: "serine"
Start Over

Search

8,129  Search Results

« Previous | 1 - 20 of 8,129 |
Number of results to display per page

Search Results

1. Formal synthesis of (+)-lactacystin from l-serine

Author:
Bulman Page, Philip C.; Goodyear, Ross L.; Chan, Yohan; Slawin, Alexandra M. Z.; Allin, Steven M.
Source:
RSC advances 2019 v.9 no.51 pp. 30019-30032
ISSN:
2046-2069
Subject:
serine,   etc   ; stereoselective synthesis;     Show all 2 Subject
Abstract:
... A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues. ...
DOI:
10.1039/c9ra07244f

2. Synthesis of a meso-Oxa-Diaminopimelic Acid Containing Peptidoglycan Pentapeptide and Coupling to the GlcNAc-anhydro-MurNAc Disaccharide

Author:
Soni, Arvind S.; Vacariu, Condarache M.; Chen, Jeff Y.; Tanner, Martin E.
Source:
Organic letters 2020 v.22 no.6 pp. 2313-2317
ISSN:
1523-7052
Subject:
serine,   etc   ; chemical reactions; chemical structure; ethyleneimine; peptides; peptidoglycans;     Show all 6 Subjects
Abstract:
... The syntheses of peptidoglycan (PG)-derived peptides containing meso-diaminopimelic acid (meso-Dap) are typically quite lengthy due to the need to prepare orthogonally protected meso-Dap. In this work, the preparation of the PG pentapeptide containing the isosteric analog meso-oxa-Dap is described. The synthesis relies on the ring opening of a peptide embedded aziridine via the attack of a serine ...
DOI:
10.1021/acs.orglett.0c00505

3. RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations

Author:
Bekbulat, Fazilet; Schmitt, Daniel; Feldmann, Anne; Huesmann, Heike; Eimer, Stefan; Juretschke, Thomas; Beli, Petra; Behl, Christian; Kern, Andreas
Source:
Journal of molecular biology 2020 v.432 no.4 pp. 1216-1234
ISSN:
0022-2836
Subject:
serine,   etc   ; autophagosomes; autophagy; fatty acids; guanosinetriphosphatase; metabolism; phosphorylation; tyrosine;     Show all 8 Subjects
Abstract:
... Autophagy is dependent on appropriate lipid supply for autophagosome formation. The regulation of lipid acquisition and the autophagy network response to lipid-limiting conditions are mostly elusive. Here, we show that the knockout of the RAB GTPase RAB18 interferes with lipid droplet catabolism, causing an impaired fatty acid release. The resulting reduced lipid-droplet-derived lipid availability ...
DOI:
10.1016/j.jmb.2019.12.031

4. PARL Protease: A Glimpse at Intramembrane Proteolysis in the Inner Mitochondrial Membrane

Author:
Lysyk, Laine; Brassard, Raelynn; Touret, Nicolas; Lemieux, M. Joanne
Source:
Journal of molecular biology 2020 v.432 no.18 pp. 5052-5062
ISSN:
0022-2836
Subject:
serine; serine proteinases,   etc   ; Parkinson disease; catalytic activity; histidine; homeostasis; hydrolysis; mammals; mitochondria; mitochondrial membrane; peptides; proteolysis; proteomics;     Show all 13 Subjects
Abstract:
... Intramembrane proteolysis, although once a controversial concept, is a widely studied field. Four classes of intramembrane proteases have been identified and are classified by their catalytic mechanism of peptide bond hydrolysis: metallo, glutamyl, aspartyl, and serine proteases. One of the most studied of these classes is the rhomboid superfamily of serine intramembrane proteases. Rhomboids consi ...
DOI:
10.1016/j.jmb.2020.04.006

5. RNA-Seq analysis reveals that spring viraemia of carp virus induces a broad spectrum of PIM kinases in zebrafish kidney that promote viral entry

Author:
Pereiro, Patricia; Álvarez-Rodríguez, Margarita; Valenzuela-Muñoz, Valentina; Gallardo-Escárate, Cristian; Figueras, Antonio; Novoa, Beatriz
Source:
Fish & shellfish immunology 2020 v.99 pp. 86-98
ISSN:
1050-4648
Subject:
protein-serine-threonine kinases; serine,   etc   ; Carp sprivivirus; Danio rerio; antineoplastic agents; apoptosis; cell cycle; enzyme inhibitors; kidneys; microRNA; neoplasms; pathogenicity; protective effect; proto-oncogenes; sequence analysis; threonine; viruses;     Show all 17 Subjects
Abstract:
... PIM kinases are a family of serine/threonine protein kinases that potentiate the progression of the cell cycle and inhibit apoptosis. Because of this, they are considered to be proto-oncogenes, and they represent an interesting target for the development of anticancer drugs. In mammals, three PIM kinases exist (PIM-1, PIM-2 and PIM-3), and different inhibitors have been developed to block their ac ...
DOI:
10.1016/j.fsi.2020.01.055

6. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

Author:
Zhang, Ting; Yin, Chaoran; Boyd, David F.; Quarato, Giovanni; Ingram, Justin P.; Shubina, Maria; Ragan, Katherine B.; Ishizuka, Takumi; Crawford, Jeremy Chase; Tummers, Bart; Rodriguez, Diego A.; Xue, Jia; Peri, Suraj; Kaiser, William J.; López, Carolina B.; Xu, Yan; Upton, Jason W.; Thomas, Paul G.; Green, Douglas R.; Balachandran, Siddharth
Source:
Cell 2020 v.180 no.6 pp. 1115-1129.e13
ISSN:
0092-8674
Subject:
protein-serine-threonine kinases; serine,   etc   ; DNA; Influenza A virus; RNA; apoptosis; cytosol; epithelium; influenza; lethal dose; lungs; mice; necroptosis; neutrophils; nuclear membrane; pathogen-associated molecular patterns; virulence;     Show all 17 Subjects
Abstract:
... Influenza A virus (IAV) is a lytic RNA virus that triggers receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated pathways of apoptosis and mixed lineage kinase domain-like pseudokinase (MLKL)-dependent necroptosis in infected cells. ZBP1 initiates RIPK3-driven cell death by sensing IAV RNA and activating RIPK3. Here, we show that replicating IAV generates Z-RNAs, which activate Z ...
DOI:
10.1016/j.cell.2020.02.050
PubMed:
32200799
PubMed Central:
PMC7153753

7. A Revised Understanding of Clostridioides difficile Spore Germination

Author:
Lawler, Amelia J.; Lambert, Peter A.; Worthington, Tony
Source:
Trends in microbiology 2020 v.28 no.9 pp. 744-752
ISSN:
0966-842X
Subject:
serine proteinases,   etc   ; Clostridium difficile; amino acids; bile salts; cortex; models; peptidoglycans; spore germination; spores;     Show all 9 Subjects
Abstract:
... The dormant resistant spores of Clostridioides difficile are transformed into metabolically active cells through the process of germination. Spore germination in C. difficile is regulated by the detection of bile salt germinants and amino acid cogerminants by pseudoproteases CspC and CspA, respectively. The germinant signal is transduced to the serine protease CspB, which processes the cortex lyti ...
DOI:
10.1016/j.tim.2020.03.004

8. Seryl-tRNA synthetase specificity for tRNASec in Bacterial Sec biosynthesis

Author:
de Freitas Fernandes, Adriano; Serrão, Vitor Hugo Balasco; Scortecci, Jéssica Fernandes; Thiemann, Otavio Henrique
Source:
Biochimica et biophysica acta 2020 v.1868 no.8 pp. 140438
ISSN:
1570-9639
Subject:
serine-tRNA ligase,   etc   ; Escherichia coli; adenosine triphosphate; aminoacylation; bacteria; biosynthesis; codons; dissociation; selenocysteine; selenoproteins; transfer RNA;     Show all 11 Subjects
Abstract:
... tRNA synthetases are responsible for decoding the molecular information, from codons to amino acids. Seryl-tRNA synthetase (SerRS), besides the five isoacceptors of tRNASᵉʳ, recognizes tRNA[Sᵉʳ]Sᵉᶜ for the incorporation of selenocysteine (Sec, U) into selenoproteins. The selenocysteine synthesis pathway is known and is dependent on several protein-protein and protein-RNA interactions. Those intera ...
DOI:
10.1016/j.bbapap.2020.140438

9. NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo)trypsin-like serine fold proteases

Author:
Denesyuk, Alexander I.; Johnson, Mark S.; Salo-Ahen, Outi M.H.; Uversky, Vladimir N.; Denessiouk, Konstantin
Source:
International journal of biological macromolecules 2020 v.153 pp. 399-411
ISSN:
0141-8130
Subject:
serine,   etc   ; catalytic activity; cysteine proteinases; disulfide bonds; eukaryotic cells; glycine (amino acid); prokaryotic cells; viruses;     Show all 8 Subjects
Abstract:
... (Chymo)trypsin-like serine fold proteases belong to the serine/cysteine proteases found in eukaryotes, prokaryotes, and viruses. Their catalytic activity is carried out using a triad of amino acids, a nucleophile, a base, and an acid. For this superfamily of proteases, we propose the existence of a universal 3D structure comprising 11 amino acids near the catalytic nucleophile and base – Nucleophi ...
DOI:
10.1016/j.ijbiomac.2020.03.025
PubMed:
32151723
PubMed Central:
PMC7124590

10. Plasmid composition and the chpG gene determine the virulence level of Clavibacter capsici natural isolates in pepper

Author:
Hwang, In Sun; Lee, Hyo Min; Oh, Eom‐Ji; Lee, Seungdon; Heu, Sunggi; Oh, Chang‐Sik
Source:
Molecular plant pathology 2020 v.21 no.6 pp. 808-819
ISSN:
1464-6722
Subject:
serine proteinases,   etc   ; Clavibacter; Gram-positive bacteria; genes; genomics; leaves; loci; necrosis; pepper; plasmids; virulence;     Show all 11 Subjects
Abstract:
... The gram‐positive bacterial species Clavibacter capsici causes necrosis and canker in pepper plants. Genomic and functional analyses of C. capsici type strain PF008 have shown that multiple virulence genes exist in its two plasmids. We aimed to identify the key determinants that control the virulence of C. capsici. Pepper leaves inoculated with 54 natural isolates exhibited significant variation i ...
DOI:
10.1111/mpp.12932

11. Structural evolution drives diversification of the large LRR‐RLK gene family

Author:
Man, Jarrett; Gallagher, Joseph P.; Bartlett, Madelaine
Source:
Thenew phytologist 2020 v.226 no.5 pp. 1492-1505
ISSN:
0028-646X
Subject:
protein-serine-threonine kinases,   etc   ; Markov chain; embryophytes; phylogeny; protein domains; raw materials; receptors;     Show all 7 Subjects
Abstract:
... ●Cells are continuously exposed to chemical signals that they must discriminate between and respond to appropriately. In embryophytes, the leucine‐rich repeat receptor‐like kinases (LRR‐RLKs) are signal receptors critical in development and defense. LRR‐RLKs have diversified to hundreds of genes in many plant genomes. Although intensively studied, a well‐resolved LRR‐RLK gene tree has remained elu ...
DOI:
10.1111/nph.16455

12. Phosphorylation Timers in the Neurospora crassa Circadian Clock

Author:
Diernfellner, Axel C.R.; Brunner, Michael
Source:
Journal of molecular biology 2020 v.432 no.12 pp. 3449-3465
ISSN:
0022-2836
Subject:
non-specific serine/threonine protein kinase,   etc   ; Neurospora crassa; circadian clocks; metabolism; phosphorylation; proteins; temperature;     Show all 7 Subjects
Abstract:
... Circadian clocks are self-sustained oscillators that orchestrate metabolism and physiology in synchrony with the 24-h day–night cycle. They are temperature compensated over a wide range and entrained by daily recurring environmental cues. Eukaryotic circadian clocks are governed by cell-based transcriptional–translational feedback loops (TTFLs). The core components of the TTFLs are largely known a ...
DOI:
10.1016/j.jmb.2020.04.004

13. Integrated Functional Omics Analysis of Flavonoid-Related Metabolism in AtMYB12 Transcript Factor Overexpressed Tomato

Author:
Meng, Xuanlin; Zhao, Xingchen; Ding, Xiangyu; Li, Yang; Cao, Guodong; Chu, Zhaohui; Su, Xiuli; Liu, Yuanchen; Chen, Xiangfeng; Guo, Jinggong; Cai, Zongwei; Ding, Xinhua
Source:
Journal of agricultural and food chemistry 2020 v.68 no.24 pp. 6776-6787
ISSN:
1520-5118
Subject:
serine,   etc   ; algorithms; ceramides; endoplasmic reticulum; flavonoids; genetic engineering; metabolism; metabolites; multiomics; phenylalanine; tomatoes;     Show all 11 Subjects
Abstract:
... Genetic engineering (GE) technology is widely used in plant modification. However, the results of modification may not exactly meet the expectations. Herein, we propose a new multi-omics method for GE plant evaluation based on the optimized use of the metID algorithm. Using this method, we found that flavonoid accumulation was at the expense of the great sacrifice of l-phenylalanine in GE tomatoes ...
DOI:
10.1021/acs.jafc.0c01894

14. The condensin subunits SMC2 and SMC4 interact for correct condensation and segregation of mitotic maize chromosomes

Author:
Wang, Hefei; Liu, Yang; Yuan, Jing; Zhang, Jing; Han, Fangpu
Source:
Theplant journal 2020 v.102 no.3 pp. 467-479
ISSN:
0960-7412
Subject:
serine,   etc   ; Zea mays; chromatids; chromosome segregation; corn; mitosis; phosphorylation; proteins; vertebrates;     Show all 9 Subjects
Abstract:
... Structural Maintenance of Chromosomes 2 (SMC2) and Structural Maintenance of Chromosomes 4 (SMC4) are the core components of the condensin complexes, which are required for chromosome assembly and faithful segregation during cell division. Because of the crucial functions of both proteins in cell division, much work has been done in various vertebrates, but little information is known about their ...
DOI:
10.1111/tpj.14639

15. Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy

Author:
Westermarck, Jukka; Neel, Benjamin G.
Source:
Cell 2020 v.181 no.3 pp. 514-517
ISSN:
0092-8674
Subject:
serine,   etc   ; cancer therapy; enzymes; humans; isozymes; neoplasms; phenothiazine; proteins; threonine; tumor suppressor genes;     Show all 10 Subjects
Abstract:
... Members of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes. Unlike most tumor suppressors, they are rarely mutated/deleted, but rather are impaired by “inhibitor proteins.” Two papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other diseases. ...
DOI:
10.1016/j.cell.2020.04.005

16. Selective PP2A Enhancement through Biased Heterotrimer Stabilization

Author:
Leonard, Daniel; Huang, Wei; Izadmehr, Sudeh; O’Connor, Caitlin M.; Wiredja, Danica D.; Wang, Zhizhi; Zaware, Nilesh; Chen, Yinghua; Schlatzer, Daniela M.; Kiselar, Janna; Vasireddi, Nikhil; Schüchner, Stefan; Perl, Abbey L.; Galsky, Matthew D.; Xu, Wenqing; Brautigan, David L.; Ogris, Egon; Taylor, Derek J.; Narla, Goutham
Source:
Cell 2020 v.181 no.3 pp. 688-701.e16
ISSN:
0092-8674
Subject:
serine,   etc   ; dissociation; enzymes; mechanism of action; neoplasms; pathogenesis; proteins; therapeutics; threonine;     Show all 9 Subjects
Abstract:
... Impairment of protein phosphatases, including the family of serine/threonine phosphatases designated PP2A, is essential for the pathogenesis of many diseases, including cancer. The ability of PP2A to dephosphorylate hundreds of proteins is regulated by over 40 specificity-determining regulatory “B” subunits that compete for assembly and activation of heterogeneous PP2A heterotrimers. Here, we reve ...
DOI:
10.1016/j.cell.2020.03.038

17. Phosphoproteomics Analysis Reveals a Potential Role of CHK1 in Regulation of Innate Immunity through IRF3

Author:
Chen, Zhen; Wang, Chao; Lei, Caoqi; Feng, Xu; Li, Chen; Jung, Sung Yun; Qin, Jun; Chen, Junjie
Source:
Journal of proteome research 2020 v.19 no.6 pp. 2264-2277
ISSN:
1535-3907
Subject:
non-specific serine/threonine protein kinase,   etc   ; innate immunity; phosphoproteins; protein phosphorylation; proteomics;     Show all 5 Subjects
Abstract:
... Inhibitors of checkpoint kinase 1 (CHK1), a central component of DNA damage and cell cycle checkpoint response, represent a promising new cancer therapy, but the global cellular functions they regulate through phosphorylation are poorly understood. To elucidate the CHK1-regulated phosphorylation network, we performed a global quantitative phosphoproteomics analysis, which revealed 142 phosphosites ...
DOI:
10.1021/acs.jproteome.9b00829

18. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Author:
Hoffmann, Markus; Kleine-Weber, Hannah; Schroeder, Simon; Krüger, Nadine; Herrler, Tanja; Erichsen, Sandra; Schiergens, Tobias S.; Herrler, Georg; Wu, Nai-Huei; Nitsche, Andreas; Müller, Marcel A.; Drosten, Christian; Pöhlmann, Stefan
Source:
Cell 2020 v.181 no.2 pp. 271-280.e8
ISSN:
0092-8674
Subject:
serine proteinases,   etc   ; Severe acute respiratory syndrome coronavirus; patients; proteinase inhibitors; receptors; therapeutics; virus transmission; China;     Show all 8 Subjects
Abstract:
... The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host cell proteases. Unravelling which cellular factors are used by SARS-CoV-2 for entry might provide i ...
DOI:
10.1016/j.cell.2020.02.052
PubMed:
32142651
PubMed Central:
PMC7102627

19. Tyrosine phosphorylation is not a relevant mechanism to modulate aquaporin 2 activity in gestational queen endometrium and placenta

Author:
Ferré‐Dolcet, Lluis; Rodríguez‐Gil, Joan Enric; Yeste, Marc; Rigau, Teresa; Rivera del Alamo, Maria Montserrat
Source:
Reproduction in domestic animals 2020 v.55 no.4 pp. 448-453
ISSN:
0936-6768
Subject:
serine,   etc   ; aquaporins; blood serum; endometrium; immunoblotting; phosphorylation; placenta; pregnancy; progesterone; tyrosine;     Show all 10 Subjects
Abstract:
... Aquaporins have been shown to be regulated by phosphorylation of serine residues, but the possible role of tyrosine residues phosphorylation has not been evaluated. Changes in the localization of aquaporin 2 (AQP2) in the queen endometrium have been related to serum progesterone levels. The aim of this study was to determine whether these AQP2‐localization changes are mediated by variations in its ...
DOI:
10.1111/rda.13636

20. Inhibition of Intestinal Proteolytic Activity of Schistocerca piceifrons piceifrons (Walker)¹ and Pterophylla beltrani (Bolívar and Bolívar)² Using Extracts from Chamaedorea radicalis Mart. Fruit

Author:
Montelongo-Ruíz, Gerardo; Olazarán-Santibáñez, Fabián Eliseo; Reyes-Zepeda, Francisco; Torres-Castillo, Jorge Ariel; de la Rosa-Manzano, Edilia; Martínez-Ávalos, José Guadalupe; Arellano-Méndez, Leonardo Uriel; Mora-Olivo, Arturo
Source:
TheSouthwestern entomologist 2020 v.45 no.1 pp. 137-146
ISSN:
0147-1724
Subject:
serine,   etc   ; Chamaedorea; Schistocerca; biological control; cysteine proteinases; enzyme inhibition; fruits; insects; intestines; proteinase inhibitors; proteolysis; ripening;     Show all 12 Subjects
Abstract:
... Inhibition of intestinal proteases by several plant species constitutes a major defense strategy against insects. However, the efficacy of this mechanism depends on the diversity and concentration of enzymatic components in insects and susceptibility of intestinal activity. Protease inhibition capacity by fruit of hardy parlor palms (Chamaedorea radicalis Mart.) and its effect on intestinal proteo ...
DOI:
10.3958/059.045.0115