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- Author:
- Fatema Matkawala; Sadhana Nighojkar; Anil Kumar; Anand Nighojkar
- Source:
- World journal of microbiology & biotechnology 2021 v.37 no.4 pp. 63
- ISSN:
- 0959-3993
- Subject:
- serine proteinases, etc ; biotechnology; catalytic activity; detergents; fabrics; hydrolysis; leather; proteolysis; solid state fermentation; submerged fermentation; substrate specificity; Show all 11 Subjects
- Abstract:
- ... Proteolytic enzymes hold a pivotal position in numerous industrial processes where hydrolysis of protein molecules is required under precise conditions. The emerging trend of biotechnological applications in recent years has witnessed a renewed interest in alkaline serine proteases extending their utility in detergent, leather, textile, food and pharmaceutical industries. A variety ...
- DOI:
- 10.1007/s11274-021-03036-z
- https://doi.org/10.1007/s11274-021-03036-z
- Author:
- E. Ploux; T. Freret; J.-M. Billard
- Source:
- Biochimica et biophysica acta 2021 v.1869 no.1 pp. 140542
- ISSN:
- 1570-9639
- Subject:
- serine, etc ; Alzheimer disease; brain; cognition; elderly; glutamic acid; neurons; quality of life; Show all 8 Subjects
- Abstract:
- ... is regulated by many mechanisms. Among is the mandatory binding of a co-agonist, such as the amino acid d-serine, in order to activate NMDAr. This mini-review presents the most recent information indicating how d-serine could contribute to mechanisms of physiological cognitive aging and also considers the divergent views relative of the role of the NMDAr co-agonist in Alzheimer's disease. ...
- DOI:
- 10.1016/j.bbapap.2020.140542
- https://doi.org/10.1016/j.bbapap.2020.140542
- Author:
- Ismael Y. Karkache; Jeyaram R. Damodaran; David H.H. Molstad; Elizabeth W. Bradley
- Source:
- Gene 2021 v.771 pp. 145362
- ISSN:
- 0378-1119
- Subject:
- serine, etc ; bone density; bone resorption; cytokines; genes; homeostasis; models; osteoclasts; proteins; therapeutics; threonine; Show all 11 Subjects
- Abstract:
- ... by the action of protein phosphatases, including members of the serine/threonine phosphatase family. Here we review the functions of serine/threonine phosphatases and their control of osteoclast differentiation and function, while highlighting deficiencies in our understanding of this understudied class of proteins within the field. ...
- DOI:
- 10.1016/j.gene.2020.145362
- https://doi.org/10.1016/j.gene.2020.145362
- Author:
- Yuan Jiang; Xiao-Chen Liu; Andressa de Zawadzki; Leif H. Skibsted
- Source:
- International dairy journal 2021 v.112 pp. 104875
- ISSN:
- 0958-6946
- Subject:
- serine, etc ; bioavailability; calcium; chelation; electrochemistry; endothermy; heat production; hydrophobic bonding; ionic strength; milk; pH; phosphates; quantum mechanics; temperature; Show all 14 Subjects
- Abstract:
- ... Calcium binding to o-phospho-l-serine (OPS), important for calcium distribution during milk processing and for calcium bioavailability, was studied electrochemically for different conditions of temperature, pH and ionic strength in combination with quantum mechanical calculations (DFT) using l-serine (Ser) as a reference compound. Calcium binding increases strongly with increasing pH for both Ser ...
- DOI:
- 10.1016/j.idairyj.2020.104875
- https://doi.org/10.1016/j.idairyj.2020.104875
- Author:
- Yalin Wang; Jun Tian; Feng Zhao; Yu Chen; Bingyi Huo; Shanshan Yu; Xiaoqi Yu; Lin Pu
- Source:
- Tetrahedron letters 2021 v.66 pp. 152803
- ISSN:
- 0040-4039
- Subject:
- serine, etc ; chemoselectivity; enantioselectivity; fluorescence; fluorescent dyes; Show all 5 Subjects
- Abstract:
- ... A diarylacetylene-containing 1,1′-bi-2-naphthol derivative (R)-2 was designed and synthesized. This compound in combination with Zn²⁺ represents the first chemoselective as well as enantioselective fluorescent probe for the biologically important amino acid serine. It was found that l-serine can greatly enhance the fluorescence of the probe at λ = 471 nm but d-serine and 17 other common amino ...
- DOI:
- 10.1016/j.tetlet.2020.152803
- https://doi.org/10.1016/j.tetlet.2020.152803
- Author:
- Jing Long; Yonghui Liu; Xihong Zhou; Liuqin He
- Source:
- Biological trace element research 2021 v.199 no.1 pp. 148-153
- ISSN:
- 0163-4984
- Subject:
- serine, etc ; blood serum; crossbreds; dietary supplements; gene expression; glutathione peroxidase; kidneys; liver; research; selenium; selenocysteine; selenoproteins; serine-tRNA ligase; skeletal muscle; thioredoxins; Show all 15 Subjects
- Abstract:
- ... The synthesis of selenocysteine and its incorporation into selenoproteins require serine during the action of seryl-tRNA synthetase. In view of this, we conducted this study to explore the effects of dietary serine supplementation on selenoprotein transcription and selenoenzyme activity in pigs. A total of 35 crossbred barrows (28 days old) were randomly assigned to five treatment groups. During ...
- DOI:
- 10.1007/s12011-020-02117-8
- https://doi.org/10.1007/s12011-020-02117-8
- Author:
- Hui Cao; Yi-Rong Liu; Teng Huang; Shuai Jiang; Zi-Hang Wang; Ying Liu; Ya-Juan Feng; Wei Huang
- Source:
- Atmospheric environment 2021 v.246 pp. 118139
- ISSN:
- 1352-2310
- Subject:
- serine, etc ; alanine; environment; hydrogen; particulates; sulfuric acid; synergism; temperature; Show all 8 Subjects
- Abstract:
- ... New particle formation (NPF) is the main source of atmospheric aerosols, and amino acids have been detected as the important components of atmospheric particulate matter. However, the role played by amino acids with different functional groups in the initial events of nucleation remains unclear. In this study, the interactions of alanine (Ala) and serine (Ser), which differ structurally by one ...
- DOI:
- 10.1016/j.atmosenv.2020.118139
- https://doi.org/10.1016/j.atmosenv.2020.118139
- Author:
- Kundan Kumar; Amol Mhetre; Girish S. Ratnaparkhi; Siddhesh S. Kamat
- Source:
- Biochemistry 2021 v.60 no.16 pp. 1312-1324
- ISSN:
- 1520-4995
- Subject:
- serine, etc ; Drosophila melanogaster; Lewis bases; active sites; bioinformatics; carboxylic ester hydrolases; computer simulation; insects; models; proteinases; proteomics; prototypes; sexual dimorphism; Show all 13 Subjects
- Abstract:
- ... The serine hydrolase (SH) superfamily is, perhaps, one of the largest functional enzyme classes in all forms of life and consists of proteases, peptidases, lipases, and carboxylesterases as representative members. Consistent with the name of this superfamily, all members, without any exception to date, use a nucleophilic serine residue in the enzyme active site to perform hydrolytic-type ...
- DOI:
- 10.1021/acs.biochem.1c00171
- https://doi.org/10.1021/acs.biochem.1c00171
9. Heterogeneity in populations of enterohaemorrhagic Escherichia coli undergoing D-serine adaptation
- Author:
- Nicky O’Boyle; Andrew J. Roe
- Source:
- Current genetics 2021 v.67 no.2 pp. 221-224
- ISSN:
- 0172-8083
- Subject:
- serine, etc ; enterohemorrhagic Escherichia coli; metabolites; phenotype; phenotypic variation; population dynamics; toxicity; Show all 7 Subjects
- Abstract:
- ... to a normally toxic metabolite, D-serine (D-ser) in enterohaemorrhagic E. coli (EHEC). Here we summarize our work in the context of population dynamics, provide further discussion on the distinction between these tolerance mechanisms and the importance of heterogeneity for maximising adaptive potential. ...
- DOI:
- 10.1007/s00294-020-01130-7
- https://doi.org/10.1007/s00294-020-01130-7
- Author:
- Hyun Ho Yun; Sunyoung Park; Myung-Jin Chung; Ji-Yoon Son; Jae-Min Park; Seung-Jun Jung; Jae-Hyuk Yim; Kyung-Ku Kang; Seongrim Byeon; Su-Min Baek; Seoung-Woo Lee; A-Rang Lee; Tae-Hwan Kim; Jin-Kyu Park; Kyu-Shik Jeong
- Source:
- Life sciences 2021 v.278 pp. 119578
- ISSN:
- 0024-3205
- Subject:
- serine, etc ; NADP (coenzyme); antioxidants; carbon tetrachloride; collagen; drugs; eosin; fibrosis; histopathology; hydrides; intraperitoneal injection; liver; liver cirrhosis; liver transplant; mice; mitochondria; olive oil; Show all 17 Subjects
- Abstract:
- ... Hepatic fibrosis is a common liver disease caused by excessive collagen deposition in the liver. Since liver transplantation is the only current treatment for cirrhosis with worsened fibrosis, a new strategy to develop anti-fibrosis drugs with no adverse effects is necessary. In recent studies, amino acids have been applied as a type of therapy in various fields. l-serine plays a major role ...
- DOI:
- 10.1016/j.lfs.2021.119578
- https://doi.org/10.1016/j.lfs.2021.119578
- Author:
- Fang Yu; Jing Chen; Zecheng Wang; Huixin Yang; Hui Li; Wenchao Jia; Shuyuan Xue; Hexin Xie; Danke Xu
- Source:
- Talanta 2021 v.224 pp. 121750
- ISSN:
- 0039-9140
- Subject:
- serine, etc ; Escherichia coli; Klebsiella pneumoniae; antibiotics; bacteria; beta-lactamase; computer simulation; detection; dissociation; drug resistance; flow cytometry; image analysis; oligonucleotides; screening; systematic evolution of ligands by exponential enrichment; virulent strains; Show all 16 Subjects
- Abstract:
- ... Klebsiella pneumoniae carbapenemase 2 (KPC-2) is a serine β-lactamase that can hydrolyze almost all β-lactam antibiotics. The drug resistant problem of bacteria expressing carbapenemases is currently a global problem, therefore, rapid and specific detection of pathogenic bacteria is urgent. In order to obtain an aptamer that can specifically recognize bacteria expressing KPC-2, we have ...
- DOI:
- 10.1016/j.talanta.2020.121750
- https://doi.org/10.1016/j.talanta.2020.121750
- Author:
- Emily Mastronardi; Kathryn Cyr; Carlos M. Monreal; Maria C. DeRosa
- Source:
- Journal of agricultural and food chemistry 2021 v.69 no.14 pp. 4294-4306
- ISSN:
- 1520-5118
- Subject:
- serine, etc ; DNA; DNA libraries; biosensors; canola; food chemistry; nitrogen; nucleotide aptamers; root exudates; systematic evolution of ligands by exponential enrichment; wheat; Show all 11 Subjects
- Abstract:
- ... Agricultural biosensing can aid decisions about crop health and maintenance, because crops release root exudates that can inform about their status. l-Serine has been found to be indicative of nitrogen uptake in wheat and canola. The development of a biosensor for l-serine could allow farmers to monitor crop nutrient demands more precisely. The development of robust l-serine-binding DNA aptamers ...
- DOI:
- 10.1021/acs.jafc.0c06796
- https://doi.org/10.1021/acs.jafc.0c06796
- Author:
- Lei Fan; Xiangzhu Zhu; Yinan Zheng; Wei Zhang; Douglas L. Seidner; Reid Ness; Harvey J. Murff; Chang Yu; Xiang Huang; Martha J. Shrubsole; Lifang Hou; Qi Dai
- Source:
- Nutrition 2021 v.89 pp. 111340
- ISSN:
- 0899-9007
- Subject:
- serine proteinases, etc ; COVID-19 infection; DNA methylation; Severe acute respiratory syndrome coronavirus 2; colorectal neoplasms; genes; genotype; magnesium; nutrition; phenotype; placebos; Show all 11 Subjects
- Abstract:
- ... The viral entry of SARS-CoV-2 requires host-expressed TMPRSS2 to facilitate the viral spike protein priming. This study aims to test the hypothesis that magnesium (Mg) treatment leads to DNA methylation changes in TMPRSS2.This study is nested within the Personalized Prevention of Colorectal Cancer Trial, a double-blind 2 × 2 factorial randomized controlled trial, which enrolled 250 participants fr ...
- DOI:
- 10.1016/j.nut.2021.111340
- https://doi.org/10.1016/j.nut.2021.111340
- Author:
- Roney Vander dos Santos; Giovanna Grillo; Henrique Fonseca; Danijela Stanisic; Ljubica Tasic
- Source:
- Toxicon 2021 v.198 pp. 64-72
- ISSN:
- 0041-0101
- Subject:
- serine proteinases, etc ; Bothrops jararaca; accidents; bagasse; blood; blood coagulation; circular dichroism spectroscopy; flavones; fluorescence; hesperetin; isomers; molecular weight; peptides; proteolysis; sequence homology; snake bites; snake venoms; Brazil; Show all 18 Subjects
- Abstract:
- ... The majority (90%) of the snakebite envenomation in Brazil accounts for Bothrops from the Viperidae family. Some snake venom serine proteases provoke blood coagulation in ophidian accident victims because of their fibrinolytic activity, one of those proteases from Bothrops jararaca (B. jararaca) has been chosen for this study. Our objectives were to isolate and characterize the target serine ...
- DOI:
- 10.1016/j.toxicon.2021.04.016
- https://doi.org/10.1016/j.toxicon.2021.04.016
- Author:
- Noora Barzkar; Zahoor Khan; Saeid Tamadoni Jahromi; Sajjad Pourmozaffar; Mohsen Gozari; Reza Nahavandi
- Source:
- International journal of biological macromolecules 2021 v.170 pp. 674-687
- ISSN:
- 0141-8130
- Subject:
- serine proteinases, etc ; blood; complement; fibrinolysis; immune response; inflammation; metastasis; proteolysis; therapeutics; Show all 9 Subjects
- Abstract:
- ... Marine organisms are rich sources of enzymes and their inhibitors having enormous therapeutic potential. Among different proteolytic enzymes, serine proteases, which can be obtained from various marine organisms show a potential to biomedical application as thrombolytic agents. Although this type of proteases plays a crucial role in almost all biological processes, their uncontrolled activity ...
- DOI:
- 10.1016/j.ijbiomac.2020.12.134
- https://doi.org/10.1016/j.ijbiomac.2020.12.134
- Author:
- Michele Monti; Giulia Guiducci; Alessio Paone; Serena Rinaldo; Giorgio Giardina; Francesca Romana Liberati; Francesca Cutruzzolá; Gian Gaetano Tartaglia
- Source:
- Computational and Structural Biotechnology Journal 2021 v.19 pp. 3034-3041
- ISSN:
- 2001-0370
- Subject:
- serine, etc ; biotechnology; carbon metabolism; cell lines; dynamic models; glycine hydroxymethyltransferase; humans; isozymes; lung neoplasms; lungs; mitochondria; molecular models; neoplasm cells; Show all 13 Subjects
- Abstract:
- ... Human serine hydroxymethyltransferase (SHMT) regulates the serine-glycine one carbon metabolism and plays a role in cancer metabolic reprogramming. Two SHMT isozymes are acting in the cell: SHMT1 encoding the cytoplasmic isozyme, and SHMT2 encoding the mitochondrial one. Here we present a molecular model built on experimental data reporting the interaction between SHMT1 protein and SHMT2 mRNA ...
- DOI:
- 10.1016/j.csbj.2021.05.019
- https://doi.org/10.1016/j.csbj.2021.05.019
- Author:
- H. R. Sachin; M. N. SharathKumar; S. Devaraja; A. H. Sneharani
- Source:
- 3 Biotech 2021 v.11 no.1 pp. 30
- ISSN:
- 2190-572X
- Subject:
- serine proteinases, etc ; Cucumis; adenosine; ammonium sulfate; anion exchange; anticoagulants; casein; enzyme activity; epinephrine; gel chromatography; mechanism of action; molecular weight; pH; phosphates; platelet aggregation; seed extracts; temperature; therapeutics; Show all 18 Subjects
- Abstract:
- ... In this study, we report the biochemical characterization of a novel serine protease from seeds of Cucumis maderaspatensis, aimed with assessing the anticoagulant and antiplatelet activities. The purified serine protease was obtained by subjecting the seed extract to ammonium sulphate precipitation followed by anion exchange and gel filtration chromatography. Twenty seven-fold purification ...
- DOI:
- 10.1007/s13205-020-02565-y
- https://doi.org/10.1007/s13205-020-02565-y
- Author:
- Zhixuan Zhao; Shuai Li; Chen Ji; Yong Zhou; Changsheng Li; Wenqin Wang
- Source:
- Genes 2021 v.12 no.3 pp. -
- ISSN:
- 2073-4425
- Subject:
- serine O-acetyltransferase, etc ; biosynthesis; corn; cystine; exons; gene expression; genetic variation; introns; methionine; natural selection; nutritive value; sequence homology; sulfur; transcription (genetics); transposons; Show all 15 Subjects
- Abstract:
- ... Improving sulfur assimilation in maize kernels is essential due to humans and animals’ inability to synthesize methionine. Serine acetyltransferase (SAT) is a critical enzyme that controls cystine biosynthesis in plants. In this study, all SAT gene members were genome-wide characterized by using a sequence homology search. The RNA-seq quantification indicates that they are highly expressed ...
- DOI:
- 10.3390/genes12030437
- https://doi.org/10.3390/genes12030437
- Author:
- Rayane Natashe Gonçalves; Dario Eluan Kalume; Maria Antonieta Ferrara; Raquel Elisa da Silva-López
- Source:
- Journal of plant biochemistry and biotechnology 2021 v.30 no.1 pp. 147-159
- ISSN:
- 0971-7811
- Subject:
- Canavalia ensiformis; biotechnology; chymotrypsin; enzyme activity; leaves; legumes; mass spectrometry; pH; plant biochemistry; plant physiology; trypsin
- Abstract:
- ... Proteases are essential for plant physiology. Leguminosae species express high level of these enzymes, however, they were only reported in seeds. The present work isolated and characterized serine proteases of the aqueous extract from Canavalia ensiformis leaf (CE-A), a tropical legume. This extract was loaded on to benzamidine affinity column, and the serine protease fraction (CE-ABza ...
- DOI:
- 10.1007/s13562-020-00578-5
- https://doi.org/10.1007/s13562-020-00578-5
- Author:
- Yasunori Iwata; Norihiko Sakai; Ikuko Yoneda; Yasuko Senda; Yukiko Sakai-Takemori; Megumi Oshima; Shiori Nakagawa-Yoneda; Hisayuki Ogura; Koichi Sato; Taichiro Minami; Shinji Kitajima; Tadashi Toyama; Yuta Yamamura; Taro Miyagawa; Akinori Hara; Miho Shimizu; Kengo Furuichi; Kouji Matsushima; Takashi Wada
- Source:
- Biochemical and biophysical research communications 2021 v.537 pp. 50-56
- ISSN:
- 0006-291X
- Subject:
- serine, etc ; Escherichia coli; bacterial adhesion; biofilm; catheters; methicillin-resistant Staphylococcus aureus; mice; peritonitis; poly(vinyl chloride); research; therapeutics; Show all 11 Subjects
- Abstract:
- ... potential of amino acids on the in vivo catheter infection model.Among the amino acids, D-Serine (D-Ser) was found to reduce MRSA’s ability to attach on plate assay. The proliferation of MRSA was not affected by the addition of D-Ser; thus, D-Ser likely only played a role in preventing attachment and biofilm formation. Then, we analyzed the expression of genes related to attachment and biofilm formation ...
- DOI:
- 10.1016/j.bbrc.2020.12.078
- https://doi.org/10.1016/j.bbrc.2020.12.078