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- Author:
- Osman Oğuz; Aysun Adan
- Source:
- Nutrition and cancer 2022 v.74 no.7 pp. 2508-2521
- ISSN:
- 1532-7914
- Subject:
- serine C-palmitoyltransferase, etc ; Western blotting; apoptosis; biomarkers; cell proliferation; ceramide glucosyltransferase; cytotoxicity; flow cytometry; lymphocytic leukemia; nutrition; phosphatidylserines; resveratrol; sphingolipids; sphingosine; therapeutics; Show all 15 Subjects
- Abstract:
- ... Targeting the key enzymes of sphingolipid metabolism including serine palmitoyltransferase (SPT), sphingosine kinase (SK) and glucosylceramide synthase (GCS) has a therapeutic importance. However, sphingolipid metabolism-mediated anti-leukemic actions of resveratrol in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) remain unknown. Therefore, we explored potential mechanisms behind r ...
- DOI:
- 10.1080/01635581.2021.2005806
- https://doi.org/10.1080/01635581.2021.2005806
- Author:
- Roberto Jhonatan Olea‐Ozuna; Sebastian Poggio; EdBergström; Elva Quiroz‐Rocha; Daniela A. García‐Soriano; Diana X. Sahonero‐Canavesi; Jonathan Padilla‐Gómez; Lourdes Martínez‐Aguilar; Isabel M. López‐Lara; Jane Thomas‐Oates; Otto Geiger
- Source:
- Environmental microbiology 2021 v.23 no.1 pp. 143-159
- ISSN:
- 1462-2912
- Subject:
- serine C-palmitoyltransferase, etc ; Caulobacter crescentus; bacteria; biosynthesis; cell differentiation; cell division; ceramides; genomics; mutants; structural genes; Show all 10 Subjects
- Abstract:
- ... Sphingolipids are essential and common membrane components in eukaryotic organisms, participating in many important cellular functions. Only a few bacteria are thought to harbour sphingolipids in their membranes, among them the well‐studied α‐proteobacterium Caulobacter crescentus, a model organism for asymmetric cell division and cellular differentiation. Here, we report that C. crescentus wild t ...
- DOI:
- 10.1111/1462-2920.15280
- https://doi.org/10.1111/1462-2920.15280
- Author:
- Xiaotong Hu; Xinyue Zhu; Wei Yu; Yiwen Zhang; Kan Yang; Zhenming Liu; Xiaoqiang Qiao; Yali Song
- Source:
- European journal of medicinal chemistry reports 2022 v.5 pp. 100041
- ISSN:
- 2772-4174
- Subject:
- serine C-palmitoyltransferase, etc ; apoptosis; carnitine palmitoyltransferase; cell proliferation; coenzyme A; cysteine; diabetes; obesity; palmitates; palmitic acid; palmitoylation; serine; threonine; Show all 13 Subjects
- Abstract:
- ... Palmitoylation occurs when fatty acids (such as palmitic acid) create covalent bonds between cysteine, serine, threonine, or other residues in proteins. The downstream effect of palmitoylation depends on the protein being palmitoylated because its blockage can render the protein useless in terms of its physiological function. Based on this, modulating the palmitoylation process becomes a good stra ...
- DOI:
- 10.1016/j.ejmcr.2022.100041
- https://doi.org/10.1016/j.ejmcr.2022.100041
- Author:
- Bhagirath Chaurasia; Li Ying; Chad Lamar Talbot; John Alan Maschek; James Cox; Edward H. Schuchman; Yoshio Hirabayashi; William L. Holland; Scott A. Summers
- Source:
- Molecular Metabolism 2021 v.45 no. pp. -
- ISSN:
- 2212-8778
- Subject:
- serine C-palmitoyltransferase, etc ; brown adipocytes; ceramides; energy expenditure; glucose; heat production; homeostasis; insulin resistance; lipolysis; metabolites; mice; mitochondria; obesity; overnutrition; phenotype; therapeutics; weight gain; Show all 17 Subjects
- Abstract:
- ... Objective: Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumulate in aging and overnutrition, are sufficient or necessary for the metabolic impairment of these thermogenic adipocytes. Methods: We generated new mou ...
- Handle:
- 10113/7330887
- DOI:
- 10.1016/j.molmet.2020.101145
- CHORUS:
- 10.1016/j.molmet.2020.101145
- https://doi.org/10.1016/j.molmet.2020.101145
- Author:
- Jongkwon Park; Yun Jung Heo; Soonjo Kwon
- Source:
- Biotechnology and bioprocess engineering 2022 v.27 no.1 pp. 30-39
- ISSN:
- 1226-8372
- Subject:
- serine C-palmitoyltransferase, etc ; bioprocessing; biotechnology; ceramides; chlorides; cobalt; coculture; cytotoxicity; epithelium; genes; hepatocytes; hypoxia; kidneys; lactate dehydrogenase; lipotoxicity; liver; metabolism; oxygen; sodium sulfite; sphingosine N-acyltransferase; Show all 20 Subjects
- Abstract:
- ... Hypoxia is one of the main pathogenetic factors in liver, an organ that exhibits lower oxygen pressure than that in other organs. Liver hepatocytes have an approximately 10-fold higher oxygen demand than other cells for homeostatic metabolism. Moreover, several clinical studies have indicated that liver diseases might aggravate some kidney diseases. Therefore, it is critical to develop in vitro mo ...
- DOI:
- 10.1007/s12257-021-0137-7
- https://doi.org/10.1007/s12257-021-0137-7
- Author:
- Weicong Cai; Xueting Wang; Jinjing Su; Jian Li; Jun Zeng; Guiling Li; Jingwen Liu
- Source:
- Journal of oceanology and limnology 2021 v.39 no.2 pp. 693-704
- ISSN:
- 2096-5508
- Subject:
- serine C-palmitoyltransferase, etc ; DNA; Emiliania huxleyi; Southern blotting; Western blotting; biochemical pathways; biogeochemistry; biosynthesis; chlorophyll; electroporation; eukaryotic cells; genes; genetic transformation; glufosinate; horizontal gene transfer; limnology; nuclear genome; oceanography; sphingolipids; thin layer chromatography; viruses; Show all 21 Subjects
- Abstract:
- ... Emiliania huxleyi is the most prominent modern coccolithophore, a group of marine unicellular eukaryotes that play a critical role in ocean biogeochemistry. Coccolithoviruses are large double stranded DNA viruses, which is responsible for the demise of large oceanic blooms formed by E. huxleyi. E. huxleyi virus (EhVs) acquired a series of enzyme-coding genes predicted to be involved in the sphingo ...
- DOI:
- 10.1007/s00343-020-9325-0
- https://doi.org/10.1007/s00343-020-9325-0
- Author:
- Hyunjun Choe; Minsun Cha; Jon D. Stewart
- Source:
- Enzyme and microbial technology 2020 v.137 pp. 109515
- ISSN:
- 0141-0229
- Subject:
- serine C-palmitoyltransferase, etc ; Sphingomonas paucimobilis; active sites; acyl coenzyme A; aldimines; biosynthesis; carboxylic acids; decarboxylation; mutagenesis; mutants; sphingolipids; technology; Show all 12 Subjects
- Abstract:
- ... Serine palmitoyltransferase (SPTase), the first enzyme of the sphingolipid biosynthesis pathway, produces 3-ketodihydrosphingosine by a Claisen-like condensation/decarboxylation reaction of l-Ser and palmitoyl-CoA (n-C₁₆-CoA). Previous structural analysis of Sphingomonas paucimobilis SPTase (SpSPTase) revealed a dynamic active site loop (RPPATP; amino acids 378–383) in which R378 (underlined) form ...
- DOI:
- 10.1016/j.enzmictec.2020.109515
- https://doi.org/10.1016/j.enzmictec.2020.109515
- Author:
- Qing Liu; Limin Zhang; Erik L. Allman; Troy D. Hubbard; Iain A. Murray; Fuhua Hao; Yuan Tian; Wei Gui; Robert G. Nichols; Philip B. Smith; Mallappa Anitha; Gary H. Perdew; Andrew D. Patterson
- Source:
- Toxicology 2021 v.458 pp. 152831
- ISSN:
- 0300-483X
- Subject:
- serine C-palmitoyltransferase, etc ; aryl hydrocarbon receptors; biosynthesis; body weight; ceramides; chromatin immunoprecipitation; gel electrophoresis; genes; lipidomics; lipogenesis; luciferase; mass spectrometry; reaction kinetics; toxicology; Show all 14 Subjects
- Abstract:
- ... Aryl hydrocarbon receptor (AHR) activation via 2,3,7,8-tetrachlorodibenzofuran (TCDF) induces the accumulation of hepatic lipids. Here we report that AHR activation by TCDF (24 μg/kg body weight given orally for five days) induced significant elevation of hepatic lipids including ceramides in mice, was associated with increased expression of key ceramide biosynthetic genes, and increased activity ...
- DOI:
- 10.1016/j.tox.2021.152831
- https://doi.org/10.1016/j.tox.2021.152831
- Author:
- Gongshe Han; Sita D. Gupta; Kenneth Gable; Dagmar Bacikova; Nivedita Sengupta; Niranjanakumari Somashekarappa; Richard L. Proia; Jeffrey M. Harmon; Teresa M. Dunn
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.3 pp. 245-259
- ISSN:
- 1388-1981
- Subject:
- serine C-palmitoyltransferase, etc ; image analysis; mammals; mutants; oligomerization; phosphorylation; precipitin tests; proteins; topology; yeasts; Show all 10 Subjects
- Abstract:
- ... Serine palmitoyltransferase (SPT), an endoplasmic reticulum-localized membrane enzymecomposed of acatalytic LCB1/LCB2 heterodimer and a small activating subunit (Tsc3 in yeast; ssSPTs in mammals), is negatively regulated by the evolutionarily conserved family of proteins known as the ORMs. In yeast, SPT, the ORMs, and the PI4P phosphatase Sac1, copurify in the “SPOTs” complex. However, neither the ...
- DOI:
- 10.1016/j.bbalip.2018.11.007
- PubMed:
- 30529276
- PubMed Central:
- PMC6373489
- https://doi.org/10.1016/j.bbalip.2018.11.007
- Author:
- Deanna Davis; John Suemitsu; Binks Wattenberg
- Source:
- Biochimica et biophysica acta 2019 v.1867 no.4 pp. 382-395
- ISSN:
- 1570-9639
- Subject:
- serine C-palmitoyltransferase, etc ; amino acid sequences; biosynthesis; cysteine; cytosol; detergents; endoplasmic reticulum; hydrophobicity; mammals; membrane permeability; models; mutants; prediction; proteins; sphingolipids; topology; Show all 16 Subjects
- Abstract:
- ... Sphingolipids are diverse lipids with essential, and occasionally opposing, functions in the cell and therefore tight control over biosynthesis is vital. Mechanisms governing this regulation are not understood. Initial steps in sphingolipid biosynthesis take place on the cytosolic face of the endoplasmic reticulum (ER). Serine palmitoyltransferase (SPT) is an ER-resident enzyme catalyzing the firs ...
- DOI:
- 10.1016/j.bbapap.2019.01.005
- PubMed:
- 30639427
- PubMed Central:
- PMC6391742
- https://doi.org/10.1016/j.bbapap.2019.01.005
- Author:
- David García-Seisdedos; Bohdan Babiy; Milagros Lerma; María E. Casado; Javier Martínez-Botas; Miguel A. Lasunción; Óscar Pastor; Rebeca Busto
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
- ISSN:
- 1388-1981
- Subject:
- serine C-palmitoyltransferase, etc ; Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; sphingosine N-acyltransferase; Show all 15 Subjects
- Abstract:
- ... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...
- DOI:
- 10.1016/j.bbalip.2020.158638
- https://doi.org/10.1016/j.bbalip.2020.158638
- Author:
- Zhenzhen Kong; Xinming Guo; Zhijian Zhao; Weizhou Wu; Lianmin Luo; Zhiguo Zhu; Shanfeng Yin; Chao Cai; Wenqi Wu; Ding Wang; Yongda Liu; Xiaolu Duan
- Source:
- Biochemical and biophysical research communications 2019 v.520 no.1 pp. 1-7
- ISSN:
- 0006-291X
- Subject:
- serine C-palmitoyltransferase, etc ; biosynthesis; cell growth; cell viability; neoplasm cells; renal cell carcinoma; research; sphingolipids; Show all 8 Subjects
- Abstract:
- ... Serine palmitoyltransferase long chain-1 (SPTLC1), which is the rate-limiting enzyme for sphingolipid biosynthesis, has been indicated to be essential for carcinoma cell survival and proliferation in recent, but its role in the regulation of renal cell carcinoma (RCC) remains unknown. In the present study, we found that SPTLC1 expression was significantly decreased in RCC tissues compared to non-t ...
- DOI:
- 10.1016/j.bbrc.2019.09.073
- https://doi.org/10.1016/j.bbrc.2019.09.073
- Author:
- Shamroop kumar Mallela; Alla Mitrofanova; Sandra Merscher; Alessia Fornoni
- Source:
- Biochimica et biophysica acta 2019 pp. -
- ISSN:
- 1388-1981
- Subject:
- serine C-palmitoyltransferase, etc ; apoptosis; cell division; cell movement; cell proliferation; ceramides; filtration; gene expression regulation; homeostasis; humans; inflammation; kidneys; macrophages; membrane fluidity; plasma membrane; proteins; yeasts; Show all 17 Subjects
- Abstract:
- ... Sphingolipids have important functions as structural components of cells but they also function as signaling molecules regulating different cellular processes such as apoptosis, cell proliferation, cell migration, cell division and inflammation. Hence, a tight regulation of the sphingolipid homeostasis is essential to maintain proper cellular functions. Mammalian ORMDL proteins are orthologues of ...
- DOI:
- 10.1016/j.bbalip.2019.158517
- PubMed:
- 31487557
- PubMed Central:
- PMC6832884
- https://doi.org/10.1016/j.bbalip.2019.158517
- Author:
- Jozef I. Nissimov; David Talmy; Liti Haramaty; Helen F. Fredricks; Ehud Zelzion; Ben Knowles; A. Murat Eren; Rebecca Vandzura; Christien P. Laber; Brittany M. Schieler; Christopher T. Johns; Kuldeep D. More; Marco J. L. Coolen; Michael J. Follows; Debashish Bhattacharya; Benjamin A. S. Van Mooy; Kay D. Bidle
- Source:
- Environmental microbiology 2019 v.21 no.6 pp. 2182-2197
- ISSN:
- 1462-2912
- Subject:
- serine C-palmitoyltransferase, etc ; Emiliania huxleyi; biogeochemistry; biosynthesis; carbon; glycosphingolipids; host range; laboratory experimentation; virulence; virus replication; viruses; Show all 11 Subjects
- Abstract:
- ... Coccolithoviruses (EhVs) are large, double‐stranded DNA‐containing viruses that infect the single‐celled, marine coccolithophore Emiliania huxleyi. Given the cosmopolitan nature and global importance of E. huxleyi as a bloom‐forming, calcifying, photoautotroph, E. huxleyi–EhV interactions play a key role in oceanic carbon biogeochemistry. Virally‐encoded glycosphingolipids (vGSLs) are virulence fa ...
- DOI:
- 10.1111/1462-2920.14633
- https://doi.org/10.1111/1462-2920.14633
- Author:
- Nai-Zheng Ding; Qian-Rong Qi; Xiao-Wei Gu; Ru-Juan Zuo; Jie Liu; Zeng-Ming Yang
- Source:
- Theriogenology 2018 v.106 pp. 227-236
- ISSN:
- 0093-691X
- Subject:
- serine C-palmitoyltransferase, etc ; immune response; messenger RNA; mice; neurodevelopment; pregnancy; progesterone; signal transduction; sphingolipids; stress response; stromal cells; uterus; Show all 12 Subjects
- Abstract:
- ... Sphingolipids play multiple roles in membrane structure, signal transduction, stress responses, neural development and immune reaction. The rate of de novo synthesis pathway of sphingolipids is regulated by two key enzymes, serine palmitoyltransferase (SPT), and ketoreductase (Kds). Here, we find that the mRNA levels of three subunits of the SPT holoenzyme (Sptlc1, Sptlc2, and Ssspta) are signific ...
- DOI:
- 10.1016/j.theriogenology.2017.09.036
- https://doi.org/10.1016/j.theriogenology.2017.09.036
- Author:
- Junliang Wan; Jian Li; Sibali Bandyopadhyay; Samuel L. Kelly; Yang Xiang; Jin Zhang; Alfred H. Merrill; Jingjing Duan
- Source:
- Journal of agricultural and food chemistry 2019 v.67 no.46 pp. 12953-12961
- ISSN:
- 1520-5118
- Subject:
- serine C-palmitoyltransferase, etc ; acyl coenzyme A; alanine; antineoplastic agents; ceramides; diet; electrospray ionization mass spectrometry; foods; glycine (amino acid); human diseases; human health; mammals; metabolites; moieties; quantitative analysis; reversed-phase liquid chromatography; serine; sphinganine; Show all 18 Subjects
- Abstract:
- ... Most common sphingolipids are comprised of “typical” sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce “atypical” sphingoid bases that lack a 1-hydroxyl group as a result of the utilization of l-alanine or glycine inste ...
- DOI:
- 10.1021/acs.jafc.9b05708
- https://doi.org/10.1021/acs.jafc.9b05708
- Author:
- Ryutaro Adachi; Yasutomi Asano; Kazumasa Ogawa; Motomi Oonishi; Yukiya Tanaka; Tomohiro Kawamoto
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- serine C-palmitoyltransferase, etc ; ceramides; dissociation; endoplasmic reticulum; enzyme activity; humans; lung neoplasms; mechanism of action; serine; Show all 9 Subjects
- Abstract:
- ... Human serine palmitoyltransferase (SPT) is a PLP-dependent enzyme residing in the endoplasmic reticulum. It catalyzes the synthesis of 3-ketodihydrosphingosine (3-KDS) from the substrates palmitoyl-CoA and l-serine. It is a rate-limiting enzyme for sphingolipid synthesis in cells. In the present study, we characterized and pharmacologically profiled a series of tetrahydropyrazolopyridine derivativ ...
- DOI:
- 10.1016/j.bbrc.2016.12.182
- https://doi.org/10.1016/j.bbrc.2016.12.182
- Author:
- Masahiro Yaguchi; Sachio Shibata; Yoshinori Satomi; Megumi Hirayama; Ryutaro Adachi; Yasutomi Asano; Takuto Kojima; Yasuhiro Hirata; Akio Mizutani; Atsushi Kiba; Yoji Sagiya
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- serine C-palmitoyltransferase, etc ; antineoplastic activity; antineoplastic agents; biosynthesis; body weight changes; ceramides; cytotoxicity; mice; models; myeloid leukemia; neoplasm cells; sphingomyelins; Show all 12 Subjects
- Abstract:
- ... Metabolic reprogramming is an essential hallmark of neoplasia. Therefore, targeting cancer metabolism, including lipid synthesis, has attracted much interest in recent years. Serine palmitoyltransferase (SPT) plays a key role in the initial and rate-limiting step of de novo sphingolipid biosynthesis, and inhibiting SPT activity prevents the proliferation of certain cancer cells. Here, we identifie ...
- DOI:
- 10.1016/j.bbrc.2017.01.075
- https://doi.org/10.1016/j.bbrc.2017.01.075
- Author:
- Wendi Teng; Yuan Li; Min Du; Xingen Lei; Siyu Xie; Fazheng Ren
- Source:
- Nutrients 2019 v.11 no.5 pp. -
- ISSN:
- 2072-6643
- Subject:
- serine C-palmitoyltransferase, etc ; Brassicaceae; biosynthesis; carcinoma; ceramides; clinical trials; gene expression regulation; genes; glucose; glucose tolerance; glycogen; homeostasis; human cell lines; humans; insulin; insulin receptor substrate proteins; insulin resistance; non-specific serine/threonine protein kinase; signal transduction; sulforaphane; transcription (genetics); triacylglycerols; vegetables; Show all 23 Subjects
- Abstract:
- ... Sulforaphane (SFA), a naturally active isothiocyanate compound from cruciferous vegetables used in clinical trials for cancer treatment, was found to possess potency to alleviate insulin resistance. But its underlying molecular mechanisms are still incompletely understood. In this study, we assessed whether SFA could improve insulin sensitivity and glucose homeostasis both in vitro and in vivo by ...
- DOI:
- 10.3390/nu11051185
- PubMed:
- 31137828
- PubMed Central:
- PMC6566605
- https://doi.org/10.3390/nu11051185
- Author:
- Moeko Toume; Motohiro Tani
- Source:
- FEBS journal 2016 v.283 no.15 pp. 2911-2928
- ISSN:
- 1742-464X
- Subject:
- serine C-palmitoyltransferase, etc ; Saccharomyces cerevisiae; biosynthesis; endocytosis; genes; guanosinetriphosphatase; microfilaments; phenotype; proteins; salt stress; sphingolipids; temperature; vacuoles; yeasts; Show all 14 Subjects
- Abstract:
- ... Rvs167 and Rvs161 in Saccharomyces cerevisiae are amphiphysin family proteins, which are involved in several important cellular events, such as invagination and scission of endocytic vesicles, and actin cytoskeleton organization. It has been reported that cellular dysfunctions caused by deletion of RVS167 or RVS161 are rescued by deletion of specific nonessential sphingolipid‐metabolizing enzyme g ...
- DOI:
- 10.1111/febs.13783
- https://doi.org/10.1111/febs.13783
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