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1. Immunogenicity of fractional-dose of inactivated poliomyelitis vaccine made from Sabin strains delivered by intradermal vaccination in Wistar rats

Author:
Yan Ma; Zhifang Ying; Jingyan Li; Qin Gu; Xiaoyu Wang; Lukui Cai; Li Shi; Mingbo Sun
Source:
Biologicals 2022 v.75 pp. 3-11
ISSN:
1045-1056
Subject:
seroconversion,   etc   ; antibody formation; antigens; immunogenicity; serotypes; vaccination; vaccines;     Show all 7 Subjects
Abstract:
... Reducing the amount of antigen is an important strategy to resolve the present shortage of IPV supply for global polio eradication. In the study, we compared the immunogenicity of adjuvanted and non-adjuvanted fractional-dose of IPV made from Sabin strains (sIPV) by intradermal (ID) administration versus the full-dose of sIPV by intramuscular (IM) administration in rats by comparing seroconversion ...
DOI:
10.1016/j.biologicals.2022.01.005

2. Nonspecific symptoms following infection with Borrelia burgdorferi sensu lato: A retrospective cohort study

Author:
Mateusz Markowicz; Michael Kundi; Gerold Stanek; Hannes Stockinger
Source:
Ticks and tick-borne diseases 2022 v.13 no.1 pp. 101851
ISSN:
1877-959X
Subject:
seroconversion,   etc   ; Borrelia burgdorferi; cohort studies; erythema; muscles; pain; questionnaires;     Show all 7 Subjects
Abstract:
... Whether infection with Borrelia burgdorferi sensu lato (sl) can cause nonspecific symptoms is a matter of controversy. We investigated whether individuals infected with B. burgdorferi sl develop unspecific symptoms more frequently than non-infected controls. Eighty-nine persons having presented with B. burgdorferi sl infection between 2015 and 2019 were asked to participate. The infection was defi ...
DOI:
10.1016/j.ttbdis.2021.101851

3. Analysis of Viral and Host Factors on Immunogenicity of 2018, 2019, and 2020 Southern Hemisphere Seasonal Trivalent Inactivated Influenza Vaccine in Adults in Brazil

Author:
Artur Capão; Maria L. Aguiar-Oliveira; Braulia C. Caetano; Thayssa K. Neves; Paola C. Resende; Walquiria A. F. Almeida; Milene D. Miranda; Olindo A.ssis Martins-Filho; David Brown; Marilda M. Siqueira; Cristiana C. Garcia
Source:
Viruses 2022 v.14 no.8 pp. -
ISSN:
1999-4915
Subject:
seroconversion,   etc   ; antibodies; hemagglutination; immunogenicity; influenza; influenza vaccines; mutation; vaccination; Brazil;     Show all 9 Subjects
Abstract:
... Annual vaccination against influenza is the best tool to prevent deaths and hospitalizations. Regular updates of trivalent inactivated influenza vaccines (TIV) are necessary due to high mutation rates in influenza viruses. TIV effectiveness is affected by antigenic mismatches, age, previous immunity, and other host factors. Studying TIV effectiveness annually in different populations is critical. ...
DOI:
10.3390/v14081692

4. Immunogenicity and Safety of High-Dose Quadrivalent Influenza Vaccine in Older Adults in Taiwan: A Phase III, Randomized, Multi-center Study

Author:
Jau-Yuan Chen; Szu-Min Hsieh; Shinn-Jang Hwang; Chiu-Shong Liu; Xiaoling Li; Marion Fournier; Ting-Yu Yeh; J. Kevin Yin; Sandrine I. Samson
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
seroconversion,   etc   ; descriptive studies; geometry; hemagglutination; immunogenicity; influenza; influenza vaccines; Taiwan;     Show all 8 Subjects
Abstract:
... High-dose influenza vaccine offers better protection against influenza/associated complications compared with standard-dose formulation. We evaluated immunogenicity and safety of high-dose influenza vaccine (QIV-HD) and standard-dose (QIV-SD) in older adults (≥65 years) in Taiwan. This was a phase III, randomized, modified double-blind, active-controlled, multi-center, descriptive study in older a ...
DOI:
10.1016/j.vaccine.2022.09.078

5. Hepatitis B Surface Antibody (Anti-HBs) Kinetics during Rituximab Chemotherapy and Performance of Hepatitis B Vaccine before Immunosuppression: Two Prospective Studies

Author:
João Marcello de Araujo-Neto; Gabriela Sousa Guimarães; Flavia Ferreira Fernandes; Marcelo A. Soares
Source:
Viruses 2022 v.14 no.8 pp. -
ISSN:
1999-4915
Subject:
seroconversion,   etc   ; antibodies; disease prevention; drug therapy; hepatitis B; immunosuppression; neoplasms; risk; vaccines;     Show all 9 Subjects
Abstract:
... Rituximab promotes strong immunosuppression leading to a high risk of hepatitis B reactivation (HBV-R) and chronic infection. Current recommendations on HBV-R prevention are expensive and poorly individualized. In resolved hepatitis B patients, previous studies suggest that anti-HBs titers before immunosuppression can predict HBV-R risk. However, guidelines claim that additional data are necessary ...
DOI:
10.3390/v14081780

6. Diagnostic Accuracy of LDBIO-Toxo II IgG and IgM Western Blot in Suspected Seroconversion in Pregnancy: A Multicentre Study

Author:
Valeria Meroni; Francesca Genco; Luigia Scudeller; Marie-Pierre Brenier-Pinchart; Hélène Fricker-Hidalgo; Coralie L’Ollivier; Luc Paris; Hervé Pelloux
Source:
Pathogens 2022 v.11 no.6 pp. -
ISSN:
2076-0817
Subject:
seroconversion,   etc   ; Toxoplasma gondii; Western blotting; automation; diagnostic techniques; pregnancy; serology; therapeutics; France;     Show all 9 Subjects
Abstract:
... The high sensitivity of the automated tests used for Toxoplasma gondii serology can yield false-positive IgM results due to aspecific reactions. On the other hand, specific therapy can delay IgG production and, therefore, the diagnosis of seroconversion. There is a need for confirmation tests to early detect seroconversions during pregnancy. We conducted a multicentre study to evaluate the diagnos ...
DOI:
10.3390/pathogens11060665

7. Antibody Responses after SARS-CoV-2 Vaccination in Patients with Liver Diseases

Author:
Athanasios-Dimitrios Bakasis; Kleopatra Bitzogli; Dimitrios Mouziouras; Abraham Pouliakis; Maria Roumpoutsou; Andreas V. Goules; Theodoros Androutsakos
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
seroconversion,   etc   ; Severe acute respiratory syndrome coronavirus 2; antibodies; elderly; immunogenicity; immunosuppression; liver; vaccination;     Show all 8 Subjects
Abstract:
... The novel mRNA-based vaccines against SARS-CoV-2 display encouraging safety and efficacy profiles. However, there is a paucity of data regarding their immunogenicity and safety in patients with liver diseases (PWLD), especially in those with cirrhosis. We prospectively assessed anti-SARS-CoV-2 S-spike IgG antibodies and neutralizing activity in fully vaccinated PWLD (n = 87) and controls (n = 40). ...
DOI:
10.3390/v14020207

8. Attenuation and genetic characteristics of a Moroccan strain of Camel pox virus

Author:
Zahra Bamouh; Jihane Hamdi; Zouhair Elkarhat; Siham Fellahi; Khalid Omari Tadlaoui; Douglas M. Watts; Ouafaa Fassi Fihri; Mehdi Elharrak
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
seroconversion,   etc   ; Camelpox virus; antibodies; camels; genome; immunogenicity; industry; tissue culture; vaccination; vaccines; virulence;     Show all 11 Subjects
Abstract:
... Camel pox (CML) is a widespread infectious viral disease of camels that causes huge economic losses to the camel industry. In this study, a local strain of Camel pox virus (CMLV) was attenuated by 175 serial passages in Vero cells and the residual pathogenicity and infectivity were tested in naïve camels at 120, 150 and 175 passage levels. Also, the safety and immunogenicity of the 175th passage w ...
DOI:
10.1016/j.vaccine.2022.09.033

9. Transforming growth factor-β: An early predictor of a functional cure in chronic hepatitis B treated with interferon

Author:
Li-Li Wu; Xiao-Yan Li; Hong Deng; Dong-Ying Xie; Yu-Rong Gu; Yan-Hua Bi; Yue-Hua Huang; Zhi-Liang Gao
Source:
Virus research 2022 v.309 pp. 198657
ISSN:
0168-1702
Subject:
seroconversion,   etc   ; blood serum; chronic hepatitis B; hepatitis B antigens; interferons; research; therapeutics; viruses;     Show all 8 Subjects
Abstract:
... The relationship between the serum transforming growth factor (TGF)-β level and HBsAg loss has not been clearly elaborated in patients with chronic hepatitis B (CHB).Two cohorts of patients with CHB were studied. Cohort A: A total of 207 hepatitis B e antigen (HBeAg)-negative CHB patients who finished ≥1 year nucleos(t)ide analogue monotherapy and sequentially received PEGylated interferon treatme ...
DOI:
10.1016/j.virusres.2021.198657

10. Association between Head-to-Chest Circumference Ratio and Intrauterine Growth-Retardation Related Outcomes during Preweaning and Postweaning

Author:
Diego Manriquez; Guilhem Poudevigne; Etienne Roche; Agnes Waret-Szkuta
Source:
Animals 2022 v.12 no.12 pp. -
ISSN:
2076-2615
Subject:
seroconversion,   etc   ; antibodies; birth weight; blood serum; chest; colostrum; growth retardation; immune response; weight gain;     Show all 9 Subjects
Abstract:
... The objective of this study is to evaluate the association between the head-to-chest circumference ratio (HCR) and birth weight (BW), colostrum intake, and average daily weight gain (ADG) at preweaning and postweaning periods. Additionally, associations between HCR and PCV-2 serum antibody titers and the PCV-2 seroconversion ratio (SCR) were assessed. Head and chest circumferences were measured at ...
DOI:
10.3390/ani12121562

11. Impact of maternal and pre-existing antibodies on immunogenicity of inactivated rotavirus vaccines

Author:
Yan Zhou; Xiaoqing Hu; Rong Chen; Jinyuan Wu; Xiaochen Lin; Chenxing Lu; Na Yin; Yaya Tang; Peng Shi; Zexin Song; Yongmei Zhao; Maosheng Sun; Hongjun Li
Source:
Vaccine 2022 v.40 no.28 pp. 3843-3850
ISSN:
0264-410X
Subject:
seroconversion,   etc   ; Rotavirus; biomedical research; blood serum; diarrhea; economic feasibility; humans; immunogenicity; neonates; pathogens; vaccination;     Show all 11 Subjects
Abstract:
... Rotavirus (RV) is a major pathogen causing severe diarrhea in infants and children aged less than 5 years. Vaccination is an economically feasible and effective strategy to prevent rotavirus infections. However, immune efficacy of live vaccines could be interfered by maternal antibodies and pre-existing antibodies of children. To develop an inactivated rotavirus vaccine (IRV), we had previously is ...
DOI:
10.1016/j.vaccine.2022.05.036

12. Serum-free purified Vero rabies vaccine is safe and immunogenic in children: Results of a randomized phase II pre-exposure prophylaxis regimen study

Author:
Beatriz Quiambao; Cecilia Montalban; Ada-Maria Minutello; Françoise Guinet-Morlot; Annick Moureau; Celine Petit; Sylvie Pichon
Source:
Vaccine 2022 v.40 no.35 pp. 5170-5178
ISSN:
0264-410X
Subject:
seroconversion,   etc   ; DNA; Philippines; cell culture; diploidy; disease prevention; humans; immune response; rabies; vaccination; vaccines;     Show all 11 Subjects
Abstract:
... A serum-free, highly purified Vero rabies vaccine (PVRV-NG) has been developed with no animal or human components and low residual DNA content. A phaseII randomized clinical study aimed to demonstrate the non-inferiority of the immune response and assess the safety profile of PVRV-NG versus a licensed human diploid cell culture rabies vaccine (HDCV) in a pre-exposure regimen in healthy children an ...
DOI:
10.1016/j.vaccine.2022.06.061

13. Silent Infection of Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b in a Commercial Chicken Broiler Flock in Italy

Author:
Federica Gobbo; Claudia Zanardello; Marco Bottinelli; Jane Budai; Francesca Bruno; Roberta De Nardi; Tommaso Patregnani; Salvatore Catania; Calogero Terregino
Source:
Viruses 2022 v.14 no.8 pp. -
ISSN:
1999-4915
Subject:
seroconversion,   etc   ; Influenza A virus; avian influenza; chickens; death; farms; flocks; mortality; pollution; slaughterhouses; viruses; Italy;     Show all 12 Subjects
Abstract:
... From October 2021 to January 2022, different incursions of clade 2.3.4.4b H5N1 HPAIV (Highly Pathogenic Avian Influenza Virus) occurred in several Italian regions with its main diffusion in Densely Poultry Populated Areas (DPPAs) of north-eastern Italy. Monitoring and control activities applied in the affected area clearly evidenced that turkeys and broilers were the most affected species, althoug ...
DOI:
10.3390/v14081600

14. Norovirus Infection in Young Nicaraguan Children Induces Durable and Genotype-Specific Antibody Immunity

Author:
Paul D. Brewer-Jensen; Yaoska Reyes; Sylvia Becker-Dreps; Fredman González; Michael L. Mallory; Lester Gutiérrez; Omar Zepeda; Edwing Centeno; Nadja Vielot; Marta Diez-Valcarce; Jan Vinjé; Ralph Baric; Lisa C. Lindesmith; Filemon Bucardo
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
seroconversion,   etc   ; Norovirus; antibodies; antigenic variation; cross reaction; gastroenteritis; genotype; genotyping; humans; neutralization tests; serotypes; vaccines;     Show all 12 Subjects
Abstract:
... There are significant challenges to the development of a pediatric norovirus vaccine, mainly due to the antigenic diversity among strains infecting young children. Characterizing human norovirus serotypes and understanding norovirus immunity in naïve children would provide key information for designing rational vaccine platforms. In this study, 26 Nicaraguan children experiencing their first norov ...
DOI:
10.3390/v14092053

15. Domestic poultry are not susceptible to avian-origin H3N2 subtype canine influenza A virus

Author:
Pei Zhou; Bo Chen; Xinkai Hu; Xiangyu Xiao; Ruohan Liu; Shoujun Li
Source:
Veterinary microbiology 2022 v.272 pp. 109501
ISSN:
0378-1135
Subject:
seroconversion,   etc   ; Influenza A virus; chickens; cloaca; dogs; eggs; evolution; pathogenicity; specific pathogen-free animals; viruses; China;     Show all 11 Subjects
Abstract:
... At present, avian-origin H3N2 subtype canine influenza virus (H3N2 CIV) is prevalent in East Asian and North American countries. The host tropism of H3N2 CIV to mammals, including mice, guinea pigs, ferrets, and pigs, has been evaluated. However, it has not previously been determined whether avian-origin H3N2 CIV can be transmitted back to birds. In China, ducks, chickens, geese, pigeons, and quai ...
DOI:
10.1016/j.vetmic.2022.109501

16. Long-term control of Coxiellosis in sheep by annual primary vaccination of gimmers

Author:
Jens Böttcher; Benjamin U. Bauer; Christina Ambros; Michaela Alex; Ursula Domes; Sabine Roth; Kerstin Boll; Martin Korneli; Karl-Heinz Bogner; Andreas Randt; Britta Janowetz
Source:
Vaccine 2022 v.40 no.35 pp. 5197-5206
ISSN:
0264-410X
Subject:
seroconversion,   etc   ; Coxiella; Q fever; bacteria; flocks; human diseases; monoclonal antibodies; nose; retrospective studies; seroprevalence; vaccination; vaccines;     Show all 12 Subjects
Abstract:
... Coxiella (C.) burnetii, a Gram-negative intracellular bacterium, causes Q fever in humans and Coxiellosis in animals. Ruminants are a primary source of human infection with C.burnetii. In 2013, vaccination was implemented in a sheep flock with 650 ewes associated with two outbreaks of Q fever in humans in 2008 and 2012. Only gimmers (yearlings) received two doses of a commercial C.burnetii phase I ...
DOI:
10.1016/j.vaccine.2022.07.029

17. Impact of the Sinopharm’s BBIBP-CorV vaccine in preventing hospital admissions and death in infected vaccinees: Results from a retrospective study in the emirate of Abu Dhabi, United Arab Emirates (UAE)

Author:
Farida Ismail AlHosani; Anderson Eduardo Stanciole; Bashir Aden; Andrey Timoshkin; Omar Najim; Walid Abbas Zaher; Fatima AlSayedsaleh AlDhaheri; Shereena Al Mazrouie; Tahir Aziz Rizvi; Farah Mustafa
Source:
Vaccine 2022 v.40 no.13 pp. 2003-2010
ISSN:
0264-410X
Subject:
seroconversion,   etc   ; COVID-19 infection; death; disease severity; hospitals; observational studies; retrospective studies; vaccination; United Arab Emirates;     Show all 9 Subjects
Abstract:
... This is a community-based, retrospective, observational study conducted to determine effectiveness of the BBIBP-CorV inactivated vaccine in the real-world setting against hospital admissions and death. Study participants were selected from 214,940 PCR-positive cases of COVID-19 reported to the Department of Health, Abu Dhabi Emirate, United Arab Emirates (UAE) between September 01, 2020 and May 1, ...
DOI:
10.1016/j.vaccine.2022.02.039

18. Seroconversion panels demonstrate anti-SARS-CoV-2 antibody development after administration of the mRNA-1273 vaccine

Author:
Francisco Belda; Oscar Mora; Monica Lopez Martinez; Nerea Torres; Ana Vivanco; Rebecca Christie; Michael Crowley
Source:
Vaccine 2022 v.40 no.22 pp. 2993-2998
ISSN:
0264-410X
Subject:
seroconversion,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibodies; health services; pandemic; vaccination; vaccines;     Show all 8 Subjects
Abstract:
... Seroconversion panels are an important tool for investigating antibody responses in acute and chronic phases of disease and development of serological assays for viral diseases including COVID-19. Globally it is anticipated that vaccines against SARS-CoV-2 will facilitate control of the current pandemic. The two COVID-19 seroconversion panels analyzed in this study were obtained from healthcare wo ...
DOI:
10.1016/j.vaccine.2022.04.006

19. Sex-specific effects of age and body mass index on antibody responses to seasonal influenza vaccines in healthcare workers

Author:
Helen Kuo; Janna R. Shapiro; Santosh Dhakal; Rosemary Morgan; Ashley L. Fink; Hsuan Liu; Jason W. Westerbeck; Kristyn E. Sylvia; Han-Sol Park; Rebecca L. Ursin; Patrick Shea; Kathryn Shaw-Saliba; Katherine Fenstermacher; Richard Rothman; Andrew Pekosz; Sabra L. Klein
Source:
Vaccine 2022 v.40 no.11 pp. 1634-1642
ISSN:
0264-410X
Subject:
seroconversion,   etc   ; blood serum; body mass index; females; health services; hospitals; influenza; influenza vaccination; influenza vaccines; males;     Show all 10 Subjects
Abstract:
... Healthcare institutions with mandatory influenza vaccination policies have over 90% vaccination rates among healthcare workers (HCWs) resulting in a population that has received the influenza vaccine in many, consecutive years. This study explored the impact of sex and other host factors in pre- and post-vaccination neutralizing antibody (nAb) titers and seroconversion against the H1N1 and H3N2 in ...
DOI:
10.1016/j.vaccine.2021.02.047

20. Previous biological therapy and impairment of the IFN-γ/IL-10 axis are associated with low immune response to 17DD-YF vaccination in patients with spondyloarthritis

Author:
Thays Zanon Casagrande; Ismael Artur da Costa-Rocha; Maria Bernadete Renoldi de Oliveira Gavi; Samira Tatiyama Miyamoto; Priscila Costa Martins; Érica Vieira Serrano; Valquiria Garcia Dinis; Ketty Lysie Libardi Lira Machado; Sonia Alves Gouvea; Larissa Carvalho Caser; Ana Carolina Campi-Azevedo; Andréa Teixeira-Carvalho; Vanessa Peruhype-Magalhães; Maria de Fatima Bissoli; Maria da Penha Gomes Gouvea; Sheila Maria Barbosa de Lima; Emily Hime Miranda; Gisela Freitas Trindade; Danielle Grillo Pacheco Lyra; Ana Paula Neves Burian; Lauro Ferreira da Silva Pinto Neto; Licia Maria Henrique da Mota; Olindo Assis Martins-Filho; Valéria Valim
Source:
Vaccine 2022 v.40 no.32 pp. 4580-4593
ISSN:
0264-410X
Subject:
seroconversion,   etc   ; adults; biomarkers; blood serum; chemokines; immune response; immunogenicity; prospective studies; seroprevalence; vaccination; vaccines; viremia; yellow fever;     Show all 13 Subjects
Abstract:
... Yellow fever (YF) vaccination is known to induce a suboptimal response in patients with autoimmune diseases (AIDs). To date, few studies have focused on the performance of 17DD-YF vaccination in patients with spondyloarthritis (SpA). In general, patients with SpA are young and have less comorbidities than other patients with AIDs, and frequently receive biological disease-modifying antirheumatic d ...
DOI:
10.1016/j.vaccine.2022.05.071