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1. An affinity interaction guided two-dimensional separation system for the screening of neuraminidase inhibitors from Reynoutria japonica Houtt. roots

Author:
Menghan Chen; Linlin Sun; Qingyun Ma; Jia Yang; Qianli Kang; Yong Yang; Rong Rong
Source:
Journal of chromatography 2022 v.1678 pp. 463338
ISSN:
0021-9673
Subject:
sialidase,   etc   ; Reynoutria japonica; drugs; ultrafiltration;     Show all 4 Subjects
Abstract:
... Discovering bioactive compounds from medicinal herbs is crucial for drug discovery. Ultrafiltration is often used in the screening of bioactive compounds from natural herbs because of its simple and rapid operations. However, the ultrafiltration results are often disturbed by the undissolved compounds and the non-target compounds, which reduces the accuracy of the results. Herein, an affinity inte ...
DOI:
10.1016/j.chroma.2022.463338

2. Influenza antivirals and animal models

Author:
C. Joaquin Caceres; Brittany Seibert; Flavio Cargnin Faccin; Stivalis Cardenas‐Garcia; Daniela S. Rajao; Daniel R. Perez
Source:
FEBS Open Bio 2022 v.12 no.6 pp. 1142-1165
ISSN:
2211-5463
Subject:
sialidase,   etc   ; antiviral agents; humans; influenza; morbidity; mortality; oseltamivir; peramivir;     Show all 8 Subjects
Abstract:
... Influenza A and B viruses are among the most prominent human respiratory pathogens. About 3–5 million severe cases of influenza are associated with 300 000–650 000 deaths per year globally. Antivirals effective at reducing morbidity and mortality are part of the first line of defense against influenza. FDA‐approved antiviral drugs currently include adamantanes (rimantadine and amantadine), neurami ...
DOI:
10.1002/2211-5463.13416

3. Changes in metabolites with harvest times of seedlings of various Korean oat (Avena sativa L.) cultivars and their neuraminidase inhibitory effects

Author:
So-Yeun Woo; Ji Yeong Yang; HanGyeol Lee; Hyoung Jae Ahn; Yong Bok Lee; Sun Hee Do; Jeong Yoon Kim; Woo Duck Seo
Source:
Food chemistry 2022 v.373 pp. 131429
ISSN:
0308-8146
Subject:
sialidase,   etc   ; Avena sativa; cultivars; food chemistry; harvest date; metabolites; oats;     Show all 7 Subjects
Abstract:
... Oats and their seeds, stems, and leaves are approved for use as safe food ingredients. Oat seedlings are environmentally friendly and are becoming increasingly popular as they provide several health benefits. We used the UPLC-CAD to quantitatively analyze isolated compounds (1–11) between 15 cultivars of oat seedlings and their harvest time. Maximum average amount of total contents of isolated com ...
DOI:
10.1016/j.foodchem.2021.131429

4. Estimation of Avian Influenza Viruses in Water Environments of Live Poultry Markets in Changsha, China, 2014 to 2018

Author:
Xiaoyu Li; Rusheng Zhang; Zheng Huang; Dong Yao; Lei Luo; Jingfang Chen; Wen Ye; Lingzhi Li; Shan Xiao; Xiaolei Liu; Xinhua Ou; Biancheng Sun; Mingzhong Xu; Rengui Yang; Xian Zhang
Source:
Food and environmental virology 2022 v.14 no.1 pp. 30-39
ISSN:
1867-0334
Subject:
sialidase,   etc   ; amino acids; avian influenza; hemagglutinins; monitoring; poultry; virology; China;     Show all 8 Subjects
Abstract:
... In routine surveillance for avian influenza viruses (AIVs) in the environments of live poultry markets (LPMs), certain samples were positive for AIVs type A while negative for subtypes (e.g., H5, H7, and H9). However, little attention has been paid to these unsubtyped AIVs samples. To reveal the dynamic distribution and molecular characteristics of AIVs, especially the unsubtyped AIVs, we reported ...
DOI:
10.1007/s12560-021-09506-9

5. Low Pathogenicity H7N3 Avian Influenza Viruses Have Higher Within-Host Genetic Diversity Than a Closely Related High Pathogenicity H7N3 Virus in Infected Turkeys and Chickens

Author:
Christina M. Leyson; Miriã F. Criado; Sungsu Youk; Mary J. Pantin-Jackwood
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
sialidase,   etc   ; avian influenza; genes; genetic variation; hemagglutinins; mutation; pathogenicity; pathotypes; viruses;     Show all 9 Subjects
Abstract:
... Within-host viral diversity offers a view into the early stages of viral evolution occurring after a virus infects a host. In recent years, advances in deep sequencing have allowed for routine identification of low-frequency variants, which are important sources of viral genetic diversity and can potentially emerge as a major virus population under certain conditions. We examined within-host viral ...
DOI:
10.3390/v14030554

6. Identification of enterotoxigenic Bacteroides fragilis in patients with diarrhea: A study targeting 16S rRNA, gyrB and nanH genes

Author:
Rosa Amiri; Zahra Norouzbabaei; Naeemeh Kalali; Sedighe Ghourchian; Mehdi Yaseri; Alireza Abdollahi; Masoumeh Douraghi
Source:
Anaerobe 2022 v.75 pp. 102546
ISSN:
1075-9964
Subject:
sialidase,   etc   ; Bacteroides fragilis; DNA topoisomerase (ATP-hydrolysing); agar; diarrhea; genes; toxins;     Show all 7 Subjects
Abstract:
... We aimed to identify the enterotoxigenic Bacteroides fragilis (ETBF) and bft subtypes among patients with diarrhea. In addition, we assessed whether DNA gyrase subunit B (gyrB) and neuraminidase (nanH) genes are useful determinants for identification of B. fragilis compared to 16S rRNA sequencing as a reference method. The 530 fecal specimens were cultured on BBE agar. The colonies which supposed ...
DOI:
10.1016/j.anaerobe.2022.102546

7. O‐acetylesterase activity of Bifidobacterium bifidum sialidase facilities the liberation of sialic acid and encourages the proliferation of sialic acid scavenging Bifidobacterium breve

Author:
Tatsunari Yokoi; Keita Nishiyama; Yuka Kushida; Kazuya Uribayashi; Takahiro Kunihara; Rika Fujimoto; Yuji Yamamoto; Masahiro Ito; Tsuyoshi Miki; Takeshi Haneda; Takao Mukai; Nobuhiko Okada
Source:
Environmental microbiology reports 2022 v.14 no.4 pp. 637-645
ISSN:
1758-2229
Subject:
sialidase,   etc   ; Bifidobacterium bifidum; Bifidobacterium breve; cattle; esterases; microbiology; mucins; polysaccharides; sialic acid;     Show all 9 Subjects
Abstract:
... Bifidobacterium bifidum possesses two extracellular sialidases (SiaBb1 and SiaBb2) that release free sialic acid from mucin sialoglycans, which can be utilized via cross‐feeding by Bifidobacterium breve that, otherwise, is prevented from utilizing this nutrient source. Modification of sialic acids with O‐acetyl esters is known to protect mucin glycans from degradation by bacterial sialidases. Comp ...
DOI:
10.1111/1758-2229.13083

8. Sialic Acid Derivatization of Fluorescently Labeled N-Glycans Allows Linkage Differentiation by Reversed-Phase Liquid Chromatography–Fluorescence Detection–Mass Spectrometry

Author:
Alan B. Moran; Richard A. Gardner; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer; Daniel I. R. Spencer
Source:
Analytical chemistry 2022 v.94 no.18 pp. 6639-6648
ISSN:
1520-6882
Subject:
sialidase,   etc   ; analytical chemistry; derivatization; desorption; esterification; fluorescence; glycomics; liquid chromatography; sialic acid;     Show all 9 Subjects
Abstract:
... Sialic acids have diverse biological roles, ranging from promoting up to preventing protein and cellular recognition in health and disease. The various functions of these monosaccharides are owed, in part, to linkage variants, and as a result, linkage-specific analysis of sialic acids is an important aspect of glycomic studies. This has been addressed by derivatization strategies using matrix-assi ...
DOI:
10.1021/acs.analchem.1c02610

9. Isomer-specific biomarker discovery in multiple myeloma with dual-derivatized N-glycans

Author:
Chang Wang; Chaoying Zhang; Xinchang Gao; Jin-Ming Lin
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.18 pp. 5617-5626
ISSN:
1618-2642
Subject:
sialidase,   etc   ; analytical chemistry; biomarkers; blood serum; glycosylation; glycosyltransferases; humans; myeloma; polysaccharides; sialic acid;     Show all 10 Subjects
Abstract:
... As one of the most important post-translational modifications, protein glycosylation plays vital role in various physiological processes. With multitudinous glycosyltransferases, N-glycans present structural diversity in linkages and branching styles. Structure-specific glycan profiling may provide more potential biological information than compositional profiling. In this work, N-glycans released ...
DOI:
10.1007/s00216-022-04010-w

10. Oseltamivir modified bovine serum albumin inhibits neuraminidase activity and accumulates virion particles to disturb influenza virus replication

Author:
Hai-Juan Qin; Shuang Li; Yu-Bo Zhu; Yan-Bin Bao; Qi Tang; Wen-Bin Liu; Ming Zhong; YueTao Zhao; Yang Yang
Source:
Carbohydrate research 2022 v.520 pp. 108631
ISSN:
0008-6215
Subject:
sialidase,   etc   ; Orthomyxoviridae; absorbents; bovine serum albumin; carbohydrates; chemical bonding; influenza; oseltamivir; research; virion; virus replication;     Show all 11 Subjects
Abstract:
... The preparation of oseltamivir-bovine serum albumin conjugate (OS-BSA) for use as a multivalent influenza neuraminidase (NA) inhibitor is reported. Briefly, the oseltamivir azidohexyl ester was synthesized and covalently bound via an orthogonal attachment to bicyclononyne-modified BSA using copper-free click chemistry. Primary antiviral assays on NA protein and cellular levels showed that the synt ...
DOI:
10.1016/j.carres.2022.108631

11. Molecular characterization and evolution dynamics of influenza B viruses circulating in Germany from season 1996/1997 to 2019/2020

Author:
Alla Heider; Marianne Wedde; Ralf Dürrwald; Thorsten Wolff; Brunhilde Schweiger
Source:
Virus research 2022 v.322 pp. 198926
ISSN:
0168-1702
Subject:
sialidase,   etc   ; amino acids; antigenic variation; burden of disease; epitopes; glycosylation; hemagglutinins; influenza; phylogeny; research; viruses; Germany;     Show all 12 Subjects
Abstract:
... Influenza B viruses are responsible for significant disease burden caused by viruses of both the Yamagata- and Victoria-lineage. Since the circulating patterns of influenza B viruses in different countries vary we investigated molecular properties and evolution dynamics of influenza B viruses circulating in Germany between 1996 and 2020. A change of the dominant lineage occurred in Germany in seve ...
DOI:
10.1016/j.virusres.2022.198926

12. Neu1 deficiency increases the susceptibility of zebrafish to Edwardsiella piscicida infection via lysosomal dysfunction

Author:
Daichi Sahashi; Yurina Kubo; Mika Ishii; Asami Ikeda; Chiharu Yamasaki; Masaharu Komatsu; Kazuhiro Shiozaki
Source:
Gene 2022 v.836 pp. 146667
ISSN:
0378-1119
Subject:
sialidase,   etc   ; Danio rerio; Edwardsiella piscicida; bacterial infections; chloroquine; fish; genes; glycoconjugates; lysosomes; macrophages; mortality; oligosaccharides; pathogens;     Show all 13 Subjects
Abstract:
... Neu1 is a lysosomal glycosidase that catalyzes the removal of sialic acids from glycoconjugates. Although Neu1 sialidase is highly conserved among vertebrates, the role of fish Neu1 is not fully understood because of its unique aquatic living situation. Compared to land animals, fish have a higher chance of bacterial infection, and to understand the role of fish Neu1, the susceptibility of Neu1 kn ...
DOI:
10.1016/j.gene.2022.146667

13. Activity of the glycosidases β-galactosidase, α-l-fucosidase, β-N-acetyl-hexosaminidase, and sialidase in uterine tissues from female dogs in diestrus with and without pyometra

Author:
Marek Szczubiał; Marta Kankofer; Jacek Wawrzykowski; Roman Dąbrowski; Mariola Bochniarz; Piotr Brodzki
Source:
Theriogenology 2022 v.177 pp. 133-139
ISSN:
0093-691X
Subject:
sialidase,   etc   ; colorimetry; densitometry; diestrus; dogs; females; glycoproteins; pathogenesis; polyacrylamide gel electrophoresis; pyometra; spaying; sugar content; sugars;     Show all 13 Subjects
Abstract:
... This study aimed to compare the activity of selected glycosidases (β-galactosidase, α-l-fucosidase, β-N-acetyl-hexosaminidase, and sialidase) in homogenates of uterine tissues obtained from female dogs with and without pyometra. In addition, it examined the availability of substrates for these glycosidases in the homogenates. The study was carried out on female dogs undergoing ovariohysterectomy f ...
DOI:
10.1016/j.theriogenology.2021.10.020

14. Alternating 3 different influenza vaccines for swine in Europe for a broader antibody response and protection

Author:
Anna Parys; Elien Vandoorn; Koen Chiers; Kristien Van Reeth
Source:
BMC veterinary research 2022 v.53 no.1 pp. 44
ISSN:
1297-9716
Subject:
sialidase,   etc   ; Influenza A virus; antibodies; antibody formation; hemagglutination; swine; swine influenza; vaccination; veterinary medicine; viruses; Europe;     Show all 11 Subjects
Abstract:
... Heterologous prime-boost vaccination with experimental or commercial influenza vaccines has been successful in various animal species. In this study, we have examined the efficacy of alternating 3 different European commercial swine influenza A virus (swIAV) vaccines: the trivalent Respiporc® FLU3 (TIV), the bivalent GRIPORK® (BIV) and the monovalent Respiporc® FLUpan H1N1 (MOV). Five groups of 6 ...
DOI:
10.1186/s13567-022-01060-x

15. Affinity ultrafiltration and UPLC-HR-Orbitrap-MS based screening of neuraminidase inhibitors from Angelica pubescens

Author:
Zhenhua Tian; Luping Sun; Bingqing Chi; Zhen Du; Xiumei Zhang; Yuecheng Liu; Honglei Zhou
Source:
Journal of chromatography 2022 v.1208 pp. 123398
ISSN:
1570-0232
Subject:
sialidase,   etc   ; Angelica pubescens; Oriental traditional medicine; chlorogenic acid; drugs; mass spectrometry; methoxsalen; ultra-performance liquid chromatography; ultrafiltration;     Show all 9 Subjects
Abstract:
... Traditional Chinese medicine is a rich source of natural products and has a long history of use because of its remarkable clinical efficacy. In the present study, the chemical constitutes of Angelica pubescens were studied by ultra high performance liquid chromatography and high-resolution Orbitrap mass spectrometry (UPLC-HR-Orbitrap-MS). A total of 78 compounds were identified and the main compos ...
DOI:
10.1016/j.jchromb.2022.123398

16. Bivalent hemagglutinin and neuraminidase influenza replicon particle vaccines protect pigs against influenza a virus without causing vaccine associated enhanced respiratory disease

Author:
Meghan Wymore Brand; Tavis K. Anderson; Pravina Kitikoon; J. Brian Kimble; Nicholas Otis; Phillip C. Gauger; Carine K. Souza; Bryan Kaplan; Mark Mogler; Erin Strait; Amy L. Vincent Baker
Source:
Vaccine 2022 v.40 no.38 pp. 5569-5578
ISSN:
0264-410X
Subject:
sialidase,   etc   ; Influenza A virus; RNA; antibodies; antigenic variation; hemagglutinins; necropsy; pathogens; replicon; swine; swine influenza; vaccines; viruses;     Show all 13 Subjects
Abstract:
... Alphavirus-derived RNA replicon particle (RP) vaccines represent the next generation of swine influenza A virus (IAV) vaccines, as they were shown to be safe, effective, and offer advantages over traditional vaccine platforms. IAV is a significant respiratory pathogen of swine and there is a critical need to improve current commercial swine IAV vaccine platforms. Adjuvanted whole inactivated virus ...
Datasets:
Data from: Bivalent hemagglutinin and neuraminidase influenza replicon particle vaccines protect without causing vaccine associated enhanced respiratory disease in swine
DOI:
10.1016/j.vaccine.2022.07.042

17. Isolation of Genetically Diverse H5N8 Avian Influenza Viruses in Poultry in Egypt, 2019–2021

Author:
Ahmed H. Salaheldin; Ahmed R. Elbestawy; Abdelkader M. Abdelkader; Hesham A. Sultan; Awad A. Ibrahim; Hatem S. Abd El-Hamid; Elsayed M. Abdelwhab
Source:
Viruses 2022 v.14 no.7 pp. -
ISSN:
1999-4915
Subject:
sialidase,   etc   ; Influenza A virus; avian influenza; hemagglutinins; risk; sequence analysis; socioeconomic factors; vaccination; viruses; Egypt; Middle East;     Show all 11 Subjects
Abstract:
... The global spread of avian influenza virus (AIV) of clade 2.3.4.4b since 2016 has caused severe losses in wild birds and poultry and has posed a risk for the infection of mammals including humans. The vaccination of poultry has been used to limit the spread of the virus and mitigate its socioeconomic impact. Here, we describe H5N8 epidemics in chickens, turkeys and ducks from different localities ...
DOI:
10.3390/v14071431

18. Sialic acid-containing glycans play a role in the activity of snake venom proteases

Author:
Carolina Brás-Costa; Alison Felipe Alencar Chaves; Dilza Trevisan-Silva; Milene C. Menezes; Marisa M.T. Rocha; Daniela Cajado-Carvalho; Débora Andrade-Silva; Solange M.T. Serrano
Source:
Biochimie 2022 pp. -
ISSN:
0300-9084
Subject:
sialidase,   etc   ; Bothrops; fibrinogen; glycoproteins; glycosylation; humans; hybrids; metalloproteinases; polysaccharides; proteolysis; proteome; serine proteinases; sialic acid; snake venoms;     Show all 14 Subjects
Abstract:
... Structural variability is a feature of snake venom proteins, and glycosylation is a post-translational modification that contributes to the diversification of venom proteomes. Studies by our group have shown that Bothrops venoms are distinctly defined by their glycoprotein content, and that most hybrid/complex N-glycans identified in these venoms contain sialic acid. Considering that metalloprotea ...
DOI:
10.1016/j.biochi.2022.09.011

19. Novel Combined Enzymatic Approach to Analyze Nonsialylated N-Linked Glycans through MALDI Imaging Mass Spectrometry

Author:
Andrew T. DelaCourt; Hongyan Liang; Richard R. Drake; Peggi M. Angel; Anand S. Mehta
Source:
Journal of proteome research 2022 v.21 no.8 pp. 1930-1938
ISSN:
1535-3907
Subject:
sialidase,   etc   ; enzymatic treatment; glycoproteins; glycosylation; mass spectrometry; peptide-N4-(N-acetyl-beta-glucosaminyl) asparagine amidase; polysaccharides; proteome; research;     Show all 9 Subjects
Abstract:
... Alterations to N-glycan expression are relevant to the progression of various diseases, particularly cancer. In many cases, specific N-glycan structural features such as sialylation, fucosylation, and branching are of specific interest. A novel MALDI imaging mass spectrometry workflow has been recently developed to analyze these features of N-glycosylation through the utilization of endoglycosidas ...
DOI:
10.1021/acs.jproteome.2c00193

20. Improved Subtyping of Avian Influenza Viruses Using an RT-qPCR-Based Low Density Array: ‘Riems Influenza a Typing Array’, Version 2 (RITA-2)

Author:
Kareem E. Hassan; Ann Kathrin Ahrens; Ahmed Ali; Magdy F. El-Kady; Hafez M. Hafez; Thomas C. Mettenleiter; Martin Beer; Timm Harder
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
sialidase,   etc   ; Influenza A virus; Newcastle disease; avian influenza; birds; diagnostic techniques; epizootic diseases; hemagglutinins; infectious bronchitis; pathotypes; provenance;     Show all 11 Subjects
Abstract:
... Avian influenza virus (AIV) variants emerge frequently, which challenges rapid diagnosis. Appropriate diagnosis reaching the sub- and pathotype level is the basis of combatting notifiable AIV infections. Real-time RT-PCR (RT-qPCR) has become a standard diagnostic tool. Here, a total of 24 arrayed RT-qPCRs is introduced for full subtyping of 16 hemagglutinin and nine neuraminidase subtypes of AIV. ...
DOI:
10.3390/v14020415