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1. Local and Universal Action: The Paradoxes of Indole Signalling in Bacteria

Author:
Zarkan, Ashraf; Liu, Junyan; Matuszewska, Marta; Gaimster, Hannah; Summers, David K.
Source:
Trends in microbiology 2020 v.28 no.7 pp. 566-577
ISSN:
0966-842X
Subject:
signal transduction,   etc   ; biochemical mechanisms; indoles; microbial physiology;     Show all 4 Subjects
Abstract:
... Indole is a signalling molecule produced by many bacterial species and involved in intraspecies, interspecies, and interkingdom signalling. Despite the increasing volume of research published in this area, many aspects of indole signalling remain enigmatic. There is disagreement over the mechanism of indole import and export and no clearly defined target through which its effects are exerted. Prog ...
DOI:
10.1016/j.tim.2020.02.007

2. Celebrating Discoveries in Wnt Signaling: How One Man Gave Wings to an Entire Field

Author:
van Amerongen, Renée
Source:
Cell 2020 v.181 no.3 pp. 487-491
ISSN:
0092-8674
Subject:
signal transduction,   etc   ; biomedical research; neoplasms; stem cells;     Show all 4 Subjects
Abstract:
... This year’s Gairdner Foundation Award for Biomedical Research goes to Roel Nusse for his pioneering work on the Wnt signaling pathway and its many roles in development, cancer, and stem cells. ...
DOI:
10.1016/j.cell.2020.03.033

3. A sulfated polysaccharide from the edible flesh of Cipangopaludina chinensis inhibits angiogenesis to enhance atherosclerotic plaque stability

Author:
Xiong, Qingping; Li, Hailun; Zhou, Li; Liang, Jian; Zhang, Ziyun; Han, Yun; Jing, Yi; Hu, Youdong; Shi, Yingying; Xu, Tingting; Qian, Guoqing; Yuan, Jun
Source:
Journal of functional foods 2020 v.66 pp. 103800
ISSN:
1756-4646
Subject:
signal transduction,   etc   ; angiogenesis; phosphatidylinositol 3-kinase; polysaccharides;     Show all 4 Subjects
Abstract:
... Sulfated polysaccharide (CCPSs) of Cipangopaludina chinensis has shown significant antiangiogenic activity. In view of the closely relationship between angiogenesis and atherosclerotic plaque vulnerability, we speculated that CCPSs may stabilize atherosclerotic plaques by inhibiting angiogenesis. The purpose of this study was to demonstrate a correlation between the role of CCPSs in stabilizing pl ...
DOI:
10.1016/j.jff.2020.103800

4. LEAFY COTYLEDONs (LECs): master regulators in plant embryo development

Author:
Kumar, Vijay; Jha, Priyanka; Van Staden, Johannes
Source:
Plant cell, tissue, and organ culture 2020 v.140 no.3 pp. 475-487
ISSN:
0167-6857
Subject:
signal transduction,   etc   ; cotyledons; embryogenesis; genes; transcription factors;     Show all 5 Subjects
Abstract:
... In plants, somatic embryo development is regulated by a complex group or network of transcription factors (TFs). The LEAFY COTYLEDON (LEC) TFs are significant key regulators that promote the initiation of somatic embryo formation and biological processes of the embryo maturation phase. The LEC gene has been implicated to act as unique regulators in plant embryogenesis, growth and development via d ...
DOI:
10.1007/s11240-019-01752-x

5. The Cytoskeleton as Regulator of Cell Signaling Pathways

Author:
Moujaber, Ossama; Stochaj, Ursula
Source:
Trends in biochemical sciences 2020 v.45 no.2 pp. 96-107
ISSN:
0968-0004
Subject:
signal transduction,   etc   ; actin; intermediate filaments; interphase; microtubules;     Show all 5 Subjects
Abstract:
... During interphase, filamentous actin, microtubules, and intermediate filaments regulate cell shape, motility, transport, and interactions with the environment. These activities rely on signaling events that control cytoskeleton properties. Recent studies uncovered mechanisms that go far beyond this one-directional flow of information. Thus, the three branches of the cytoskeleton impinge on signali ...
DOI:
10.1016/j.tibs.2019.11.003

6. Emerging Principles of Selective ER Autophagy

Author:
Wilkinson, Simon
Source:
Journal of molecular biology 2020 v.432 no.1 pp. 185-205
ISSN:
0022-2836
Subject:
signal transduction,   etc   ; autophagy; endoplasmic reticulum; lysosomes; metabolism;     Show all 5 Subjects
Abstract:
... The endoplasmic reticulum (ER) is a fundamental organelle in cellular metabolism and signal transduction. It is subject to complex, dynamic sculpting of morphology and composition. Degradation of ER content has an important role to play here. Indeed, a major emerging player in ER turnover is ER-phagy, the degradation of ER fragments by selective autophagy, particularly macroautophagy. This article ...
DOI:
10.1016/j.jmb.2019.05.012
PubMed:
31100386
PubMed Central:
PMC6971691

7. Reciprocal Regulation of Mitochondrial Fission and Fusion

Author:
Sabouny, Rasha; Shutt, Timothy E.
Source:
Trends in biochemical sciences 2020 v.45 no.7 pp. 564-577
ISSN:
0968-0004
Subject:
signal transduction,   etc   ; energy; mitochondria; quality control; reactive oxygen species;     Show all 5 Subjects
Abstract:
... The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion mediate energy output, production of reactive oxygen species (ROS), and mitochondrial quality control. As our understanding of the molecular machinery and mechanisms regulating dynamic changes in the mitochondrial net ...
DOI:
10.1016/j.tibs.2020.03.009

8. Rapamycin treatment maintains developmental potential of oocytes in mice and follicle reserve in human cortical fragments grafted into immune-deficient mice

Author:
Yorino sato,; Yorino Sato,; Kawamura, Kazuhiro
Source:
Molecular and cellular endocrinology 2020 v.504 pp. 110694
ISSN:
0303-7207
Subject:
signal transduction,   etc   ; humans; neoplasms; oocytes; ovarian follicles; patients; rapamycin; women;     Show all 8 Subjects
Abstract:
... The ovarian follicle pool size is limited; it decreases with age and following germ cell-damaging chemo- or radiation therapies. Due to a trend of delaying child-bearing age in the modern society, it is important to investigate the possibility to maintain the follicle reserve for middle-aged women and cancer-bearing patients subject to therapies. Earlier studies demonstrated the important role of ...
DOI:
10.1016/j.mce.2019.110694

9. Light Perception: A Matter of Time

Author:
Sanchez, Sabrina E.; Rugnone, Matias L.; Kay, Steve A.
Source:
Molecular plant 2020 v.13 no.3 pp. 363-385
ISSN:
1674-2052
Subject:
signal transduction,   etc   ; circadian clocks; environmental factors; photoreceptors; physiology;     Show all 5 Subjects
Abstract:
... Optimizing the perception of external cues and regulating physiology accordingly help plants to cope with the constantly changing environmental conditions to which they are exposed. An array of photoreceptors and intricate signaling pathways allow plants to convey the surrounding light information and synchronize an endogenous timekeeping system known as the circadian clock. This biological clock ...
DOI:
10.1016/j.molp.2020.02.006
PubMed:
32068156
PubMed Central:
PMC7056494

10. Advances in biosensing technologies for analysis of cancer-derived exosomes

Author:
Xu, Huiying; Ye, Bang-Ce
Source:
Trends in analytical chemistry 2020 v.123 pp. 115773
ISSN:
0165-9936
Subject:
signal transduction,   etc   ; biomarkers; biosensors; exosomes; monitoring; neoplasm cells; neoplasms; therapeutics;     Show all 8 Subjects
Abstract:
... Exosomes play an important role in intercellular communication that contribute to the interaction of cancer cells with the tumor microenvironment. The original features endow tumor-derived exosomes with distinctive opportunities to serve as sensitive biomarkers for identifying early-stage tumors and monitoring of therapeutic response non-invasively. Conventional detection techniques face a number ...
DOI:
10.1016/j.trac.2019.115773

11. Impact of HPV E5 on viral life cycle via EGFR signaling

Author:
Ilahi, Naureen Ehsan; Bhatti, Attya
Source:
Microbial pathogenesis 2020 v.139 pp. 103923
ISSN:
0882-4010
Subject:
signal transduction,   etc   ; Papillomaviridae; disease progression; keratinocytes; neoplasms; oncogene proteins; receptors;     Show all 7 Subjects
Abstract:
... Oncoprotein E5 is gaining popularity with time as the third transforming protein of Human Papillomavirus (HPV). Extensive proliferation is the distinguished feature of developing cancers, and E5 is able to stimulate keratinocytes proliferation via upregulation of EGFR signaling pathway. Thus E5 is thought to indirectly contribute to the completion of the viral life-cycle by generating the adequate ...
DOI:
10.1016/j.micpath.2019.103923

12. Phospholipids across scales: lipid patterns and plant development

Author:
Colin, Leia Axelle; Jaillais, Yvon
Source:
Current opinion in plant biology 2020 v.53 pp. 1-9
ISSN:
1369-5266
Subject:
signal transduction,   etc   ; cell membranes; hydrophobicity; phosphatidylcholines; phosphatidylserines; plant development;     Show all 6 Subjects
Abstract:
... Phospholipids are major building blocks of cell membranes and as such they have a key structural role in maintaining their integrity as a hydrophobic barrier. However, phospholipids not only have structural but also regulatory functions that are involved in a myriad of signaling pathways. Integrative approaches in plants recently revealed that certain phospholipids have distinct patterns of accumu ...
DOI:
10.1016/j.pbi.2019.08.007

13. Signal transduction pathways regulating Drosophila ovarian germline stem cells

Author:
Zhang, Heng; Cai, Yu
Source:
Current opinion in insect science 2020 v.37 pp. 1-7
ISSN:
2214-5745
Subject:
signal transduction,   etc   ; Drosophila; animal ovaries; females; germ cells; stem cells;     Show all 6 Subjects
Abstract:
... Drosophila female germline stem cells (GSCs) serve as one of the best understood stem cell types. GSCs reside in a special microenvironment, the stem cell niche, and their activity is tightly regulated by niche-derived signals. In addition to the stemness-promoting signaling molecules, the niche also generates other signaling molecules that regulate GSC differentiation. Recent studies are beginnin ...
DOI:
10.1016/j.cois.2019.10.002

14. Diversity of Bacterial Chemosensory Arrays

Author:
Yang, Wen; Briegel, Ariane
Source:
Trends in microbiology 2020 v.28 no.1 pp. 68-80
ISSN:
0966-842X
Subject:
signal transduction,   etc   ; Escherichia coli; bacteria; chemotaxis; models; protein composition;     Show all 6 Subjects
Abstract:
... Chemotaxis is crucial for the survival of bacteria, and the signaling systems associated with it exhibit a high level of evolutionary conservation. The architecture of the chemosensory array and the signal transduction mechanisms have been extensively studied in Escherichia coli. More recent studies have revealed a vast diversity of the chemosensory system among bacteria. Unlike E. coli, some bact ...
DOI:
10.1016/j.tim.2019.08.002

15. Fellowship of the rings: a saga of strigolactones and other small signals

Author:
Machin, Darren C.; Hamon‐Josse, Maxime; Bennett, Tom
Source:
Thenew phytologist 2020 v.225 no.2 pp. 621-636
ISSN:
0028-646X
Subject:
signal transduction,   etc   ; Angiospermae; embryophytes; ligands; molecular models; phylogeny; strigolactones; uncertainty;     Show all 8 Subjects
Abstract:
... Strigolactones are an important class of plant signalling molecule with both external rhizospheric and internal hormonal functions in flowering plants. The past decade has seen staggering progress in strigolactone biology, permitting highly detailed understanding of their signalling, synthesis and biological roles – or so it seems. However, phylogenetic analyses show that strigolactone signalling ...
DOI:
10.1111/nph.16135

16. LncRNA UCA1 protects cardiomyocytes against hypoxia/reoxygenation induced apoptosis through inhibiting miR-143/MDM2/p53 axis

Author:
Wang, Qiang-Sheng; Zhou, Jun; Li, Xun
Source:
Genomics 2020 v.112 no.1 pp. 574-580
ISSN:
0888-7543
Subject:
signal transduction,   etc   ; apoptosis; cardiomyocytes; hypoxia; models; myocardial infarction; rats; therapeutics;     Show all 8 Subjects
Abstract:
... lncUCA1 is abundantly expressed in the heart, indicating it may be important in maintaining normal myocardial function. However, the underlying mechanism of lncUCA1 in heart disease, particularly myocardial infarction (MI), is still in its infancy.LncUCA1 and miR-143 expression were measured in hearts of MI models. Overexpression and knockdown of lncUCA1 in neonatal rat cardiomyocytes were perform ...
DOI:
10.1016/j.ygeno.2019.04.009

17. Structural Basis of Design and Engineering for Advanced Plant Optogenetics

Author:
Banerjee, Sudakshina; Mitra, Devrani
Source:
Trends in plant science 2020 v.25 no.1 pp. 35-65
ISSN:
1360-1385
Subject:
signal transduction,   etc   ; directed evolution; engineering; optogenetics; photoreceptors; protein folding; proteins;     Show all 7 Subjects
Abstract:
... In optogenetics, light-sensitive proteins are specifically expressed in target cells and light is used to precisely control the activity of these proteins at high spatiotemporal resolution. Optogenetics initially used naturally occurring photoreceptors to control neural circuits, but has expanded to include carefully designed and engineered photoreceptors. Several optogenetic constructs are based ...
DOI:
10.1016/j.tplants.2019.10.002

18. Engineering Heart Morphogenesis

Author:
Mandrycky, Christian J.; Williams, Nisa P.; Batalov, Ivan; El-Nachef, Danny; de Bakker, Bernadette S.; Davis, Jennifer; Kim, Deok-Ho; DeForest, Cole A.; Zheng, Ying; Stevens, Kelly R.; Sniadecki, Nathan J.
Source:
Trends in biotechnology 2020
ISSN:
0167-7799
Subject:
signal transduction,   etc   ; heart; morphogenesis; stem cells; tissue engineering; tissues;     Show all 6 Subjects
Abstract:
... Recent advances in stem cell biology and tissue engineering have laid the groundwork for building complex tissues in a dish. We propose that these technologies are ready for a new challenge: recapitulating cardiac morphogenesis in vitro. In development, the heart transforms from a simple linear tube to a four-chambered organ through a complex process called looping. Here, we re-examine heart tube ...
DOI:
10.1016/j.tibtech.2020.01.006

19. Sending mixed signals: Cilia-dependent signaling during development and disease

Author:
Elliott, Kelsey H.; Brugmann, Samantha A.
Source:
Developmental biology 2019 v.447 no.1 pp. 28-41
ISSN:
0012-1606
Subject:
signal transduction,   etc   ; cilia; organelles; therapeutics;     Show all 4 Subjects
Abstract:
... Molecular signals are the guiding force of development, imparting direction upon cells to divide, migrate, differentiate, etc. The mechanisms by which a cell can receive and transduce these signals into measurable actions remains a ‘black box’ in developmental biology. Primary cilia are ubiquitous, microtubule-based organelles that dynamically extend from a cell to receive and process molecular an ...
DOI:
10.1016/j.ydbio.2018.03.007
PubMed:
29548942
PubMed Central:
PMC6136992

20. An Evolutionary Perspective on Ethylene Sensing in Microorganisms

Author:
Papon, Nicolas; Binder, Brad M.
Source:
Trends in microbiology 2019 v.27 no.3 pp. 193-196
ISSN:
0966-842X
Subject:
signal transduction,   etc   ; ethylene; microorganisms; receptors;     Show all 4 Subjects
Abstract:
... Ethylene is a gas and a plant hormone with wide ranging effects and a well defined signaling pathway. The recent identification of ethylene receptors in various microorganisms provides new insights into the early propagation of the ethylene signaling pathway in the course of evolution. ...
DOI:
10.1016/j.tim.2018.12.002