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1. Diversity of bacterial chemosensory systems

Author:
Gumerov, Vadim M; Andrianova, Ekaterina P; Zhulin, Igor B
Source:
Current opinion in microbiology 2021 v.61 pp. 42-50
ISSN:
1369-5274
Subject:
signal transduction,   etc   ; genome; systems engineering;     Show all 3 Subjects
Abstract:
... Chemosensory system is the most complex, specialized mode of signal transduction in bacteria and archaea. It is composed of several core and auxiliary protein components that are highly organized in order to deliver a fast response to changing environmental conditions. Chemosensory pathways were studied in-depth in a handful of model organisms and experimentally characterized at least to some degr ...
DOI:
10.1016/j.mib.2021.01.016

2. PAS domains in bacterial signal transduction

Author:
Stuffle, Erwin C; Johnson, Mark S; Watts, Kylie J
Source:
Current opinion in microbiology 2021 v.61 pp. 8-15
ISSN:
1369-5274
Subject:
signal transduction,   etc   ; dimerization; ligands; microbiology;     Show all 4 Subjects
Abstract:
... PAS domains are widespread, versatile domains found in proteins from all kingdoms of life. The PAS fold is composed of an antiparallel β-sheet with several flanking α-helices, and contains a conserved cleft for cofactor or ligand binding. The last few years have seen a prodigious increase in identified PAS domains and resolved PAS structures, including structures with effector and other domains. N ...
DOI:
10.1016/j.mib.2021.01.004

3. Trait dimensions in bacteria and archaea compared to vascular plants

Author:
Westoby, Mark; Gillings, Michael R.; Madin, Joshua S.; Nielsen, Daniel A.; Paulsen, Ian T.; Tetu, Sasha G.
Source:
Ecology letters 2021 v.24 no.7 pp. 1487-1504
ISSN:
1461-023X
Subject:
signal transduction,   etc   ; Archaea; ecology; operon; stress tolerance;     Show all 5 Subjects
Abstract:
... Bacteria and archaea have very different ecology compared to plants. One similarity, though, is that much discussion of their ecological strategies has invoked concepts such as oligotrophy or stress tolerance. For plants, so‐called ‘trait ecology’—strategy description reframed along measurable trait dimensions—has made global syntheses possible. Among widely measured trait dimensions for bacteria ...
DOI:
10.1111/ele.13742

4. Structure and Sequence-based Computational Approaches to Allosteric Signal Transduction: Application to Electromechanical Coupling in Voltage-gated Ion Channels

Author:
Elbahnsi, Ahmad; Delemotte, Lucie
Source:
Journal of molecular biology 2021 pp. 167095
ISSN:
0022-2836
Subject:
signal transduction,   etc   ; electric potential difference; molecular biology;     Show all 3 Subjects
Abstract:
... Allosteric signaling underlies the function of many biomolecules, including membrane proteins such as ion channels. Experimental methods have enabled specific quantitative insights into the coupling between the voltage sensing domain and the pore gate of voltage-gated ion channels, located tens of Angstrom apart from one another, as well as pinpointed specific residues and domains that participate ...
DOI:
10.1016/j.jmb.2021.167095

5. The PHY Domain Dimer Interface of Bacteriophytochromes Mediates Cross-talk between Photosensory Modules and Output Domains

Author:
Cornelia, Böhm; Nikolina, Todorović; Marco, Balasso; Geoffrey, Gourinchas; Andreas, Winkler
Source:
Journal of molecular biology 2021 pp. 167092
ISSN:
0022-2836
Subject:
signal transduction,   etc   ; chimerism; molecular biology; optogenetics; phytochrome;     Show all 5 Subjects
Abstract:
... Protein dynamics play a major role for the catalytic function of enzymes, the interaction of protein complexes or signal integration in regulatory proteins. In the context of multi-domain proteins involved in light-regulation of enzymatic effectors, the central role of conformational dynamics is well established. Light activation of sensory modules is followed by long-range signal transduction to ...
DOI:
10.1016/j.jmb.2021.167092

6. Homeostasis of the Gram-negative cell envelope

Author:
Saha, Shreya; Lach, Sarah R; Konovalova, Anna
Source:
Current opinion in microbiology 2021 v.61 pp. 99-106
ISSN:
1369-5274
Subject:
signal transduction,   etc   ; Gram-negative bacteria; biogenesis; homeostasis;     Show all 4 Subjects
Abstract:
... The Gram-negative bacterial cell envelope is a complex structure and its homeostasis is essential for bacterial survival. Envelope stress responses (ESRs) are signal transduction pathways that monitor the fidelity of envelope assembly during normal growth and also detect and repair envelope damage caused by external assaults, including immune factors, protein toxins, and antibiotics. In this revie ...
DOI:
10.1016/j.mib.2021.03.008

7. Redox switching of an artificial transmembrane signal transduction system

Author:
Trevisan, Lucia; Kocsis, Istvan; Hunter, Christopher A.
Source:
Chemical communications 2021 v.57 no.17 pp. 2196-2198
ISSN:
1364-548X
Subject:
signal transduction,   etc   ; ascorbic acid; lipid bilayers;     Show all 3 Subjects
Abstract:
... Transmission of chemical signals across lipid bilayer membranes can be achieved using membrane-anchored molecules, where molecular motion across the bilayer is controlled by switching the polarity of two different head groups. An external redox signal delivered by ascorbic acid was used to trigger membrane translocation in a synthetic transduction system. ...
DOI:
10.1039/d0cc08322d

8. SPEECHLESS and MUTE Mediate Feedback Regulation of Signal Transduction during Stomatal Development

Author:
Wakeel, Abdul; Wang, Lin; Xu, Ming
Source:
Plants 2021 v.10 no.3
ISSN:
2223-7747
Subject:
signal transduction,   etc   ; gas exchange; ligands; phosphorylation; photosynthesis;     Show all 5 Subjects
Abstract:
... Stomatal density, spacing, and patterning greatly influence the efficiency of gas exchange, photosynthesis, and water economy. They are regulated by a complex of extracellular and intracellular factors through the signaling pathways. After binding the extracellular epidermal patterning factor 1 (EPF1) and 2 (EPF2) as ligands, the receptor-ligand complexes activate by phosphorylation through the MA ...
DOI:
10.3390/plants10030432

9. Retraction: FOXO4 overexpression suppresses hypoxia-induced-MCF-7 cell survival and promotes apoptosis through the HIF-2α/Bnip3 signal pathway

Author:
Fisher, Laura
Source:
RSC advances 2021 v.11 no.8 pp. 4573
ISSN:
2046-2069
Subject:
signal transduction,   etc   ; apoptosis; cell viability; hypoxia;     Show all 4 Subjects
Abstract:
... Retraction of ‘FOXO4 overexpression suppresses hypoxia induced-MCF-7 cell survival and promotes apoptosis through HIF-2α/Bnip3 signal pathway’ by Yan Qiao et al., RSC Adv., 2019, 9, 25912–25918, DOI: 10.1039/C9RA04380B. ...
DOI:
10.1039/d1ra90014e

10. Exosomes derived from tendon stem cells promote cell proliferation and migration through the TGF β signal pathway

Author:
Li, Mingda; Jia, Jie; Li, Shanshan; Cui, Baocheng; Huang, Jiao; Guo, Zhaoming; Ma, Kun; Wang, Li; Cui, Changhao
Source:
Biochemical and biophysical research communications 2021 v.536 pp. 88-94
ISSN:
0006-291X
Subject:
signal transduction,   etc   ; cell proliferation; exosomes; research;     Show all 4 Subjects
Abstract:
... Tendon stem cells (TSCs) are a kind of progenitor cells found in tendon niches, which play a key role in the repair of tendon injuries. Exosomes that mediate cell communication are involved in physiological processes and various diseases, while the effect of exosomes derived from TSCs (TSC-exo) on TSCs is still unclear. The purpose of this study is to explore the effect of TSC-exo on TSCs. Analyzi ...
DOI:
10.1016/j.bbrc.2020.12.057

11. The regulation of protein acetylation influences the redox homeostasis to protect the heart

Author:
Zúñiga-Muñoz, Alejandra; García-Niño, Wylly-Ramsés; Carbó, Roxana; Navarrete-López, Luis-Ángel; Buelna-Chontal, Mabel
Source:
Life sciences 2021 v.277 pp. 119599
ISSN:
0024-3205
Subject:
signal transduction,   etc   ; acetylation; chromatin; heart; homeostasis; metabolism; pathogenesis;     Show all 7 Subjects
Abstract:
... The cellular damage caused by redox imbalance is involved in the pathogenesis of many cardiovascular diseases. Besides, redox imbalance is related to the alteration of protein acetylation processes, causing not only chromatin remodeling but also disturbances in so many processes where protein acetylation is involved, such as metabolism and signal transduction. The modulation of acetylases and deac ...
DOI:
10.1016/j.lfs.2021.119599

12. The role and mechanism of β-arrestin2 in signal transduction

Author:
Ma, Tian-Liang; Zhou, Yong; Zhang, Chen-Yu; Gao, Zi-Ang; Duan, Jia-Xi
Source:
Life sciences 2021 v.275 pp. 119364
ISSN:
0024-3205
Subject:
signal transduction,   etc   ; angiogenesis; autophagy; cytoplasm; plasma membrane; scaffolding proteins; therapeutics;     Show all 7 Subjects
Abstract:
... β-arrestin2 is a ubiquitously expressed scaffold protein localized on the cytoplasm and plasma membrane. It was originally found to bind to GPCRs, uncoupling G proteins and receptors' binding and inhibiting the signal transduction of the GPCRs. Further investigations have revealed that β-arrestin2 not only mediates the desensitization of GPCRs but also serves as a multifunctional scaffold to media ...
DOI:
10.1016/j.lfs.2021.119364

13. Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs

Author:
Hao, Yue; Xing, Mingjie; Gu, Xianhong
Source:
Animals 2021 v.11 no.5
ISSN:
2076-2615
Subject:
signal transduction,   etc   ; humans; oxidative stress; swine; swine production;     Show all 5 Subjects
Abstract:
... Oxidative stress refers to the dramatic increase in the production of free radicals in human and animal bodies or the decrease in the ability to scavenging free radicals, thus breaking the antioxidation–oxidation balance. Various factors can induce oxidative stress in pig production. Oxidative stress has an important effect on pig performance and healthy growth, and has become one of the important ...
DOI:
10.3390/ani11051384

14. Targeted Phosphoinositides Analysis Using High-Performance Ion Chromatography-Coupled Selected Reaction Monitoring Mass Spectrometry

Author:
Cheung, Hilaire Yam Fung; Coman, Cristina; Westhoff, Philipp; Manke, Mailin; Sickmann, Albert; Borst, Oliver; Gawaz, Meinrad; Watson, Steve P.; Heemskerk, Johan W. M.; Ahrends, Robert
Source:
Journal of proteome research 2021 v.20 no.6 pp. 3114-3123
ISSN:
1535-3907
Subject:
signal transduction,   etc   ; brain; humans; mass spectrometry; proteome; research;     Show all 6 Subjects
Abstract:
... Phosphoinositides are minor components of cell membranes, but play crucial roles in numerous signal transduction pathways. To obtain quantitative measures of phosphoinositides, sensitive, accurate, and comprehensive methods are needed. Here, we present a quantitative targeted ion chromatography–mass spectrometry-based workflow that separates phosphoinositide isomers and increases the quantitative ...
DOI:
10.1021/acs.jproteome.1c00017

15. XQ-1H promotes cerebral angiogenesis via activating PI3K/Akt/GSK3β/β-catenin/VEGF signal in mice exposed to cerebral ischemic injury

Author:
Fei, Yuxiang; Zhao, Bo; Zhu, Jianping; Fang, Weirong; Li, Yunman
Source:
Life sciences 2021 v.272 pp. 119234
ISSN:
0024-3205
Subject:
signal transduction,   etc   ; ; angiogenesis; blood flow; microvessels; neuroprotective effect; stroke;     Show all 7 Subjects
Abstract:
... Stroke still ranks as a most lethal disease worldwide. Angiogenesis during the chronic phase of ischemic stroke can alleviate ischemic injury and attenuate neurological deficit. XQ-1H is a new compound derived from the structure modification of ginkgolide B, which exerts anti-inflammation and neuroprotection against cerebral ischemic injury during the acute or subacute phase. However, whether XQ-1 ...
DOI:
10.1016/j.lfs.2021.119234

16. Cell‐permeable CaaX‐peptides affect K‐Ras downstream signaling and promote cell death in cancer cells

Author:
Klimpel, Annika; Stillger, Katharina; Wiederstein, Janica L.; Krüger, Marcus; Neundorf, Ines
Source:
TheFEBS journal 2021 v.288 no.9 pp. 2911-2929
ISSN:
1742-464X
Subject:
signal transduction,   etc   ; ; cysteine; dimethylallyltranstransferase; pancreatic neoplasms; peptides; post-translational modification;     Show all 7 Subjects
Abstract:
... Cysteine prenylation is a post‐translational modification that is used by nature to control crucial biological functions of proteins, such as membrane trafficking, signal transduction, and apoptosis. It mainly occurs in eukaryotic proteins at a C‐terminal CaaX box and is mediated by prenyltransferases. Since the discovery of prenylated proteins, various tools have been developed to study the mecha ...
DOI:
10.1111/febs.15612

17. Transcriptome profiling of runner formation induced by exogenous gibberellin in Fragaria vesca

Author:
Li, Weijia; Wang, Baotian; Sun, Hongying; Zhang, Zhihong
Source:
Scientia horticulturae 2021 v.281 pp. 109966
ISSN:
0304-4238
Subject:
signal transduction,   etc   ; Fragaria vesca; genotype; metabolism; strawberries; transcriptome;     Show all 6 Subjects
Abstract:
... To acquire more findings on the molecular mechanism of exogenous gibberellin on the growth and living process of strawberry and look into such a mechanism’s impacts, the seedlings of Fragaria vesca accession ‘Ruegen’, a non-runner genotype, were sprayed with different concentrations (0−100 mg/L) exogenous gibberellin (GA₃). When the concentration of GA₃ reached 50 mg/L, the seedlings produced runn ...
DOI:
10.1016/j.scienta.2021.109966

18. The Insect Type 1 Tyramine Receptors: From Structure to Behavior

Author:
Finetti, Luca; Roeder, Thomas; Calò, Girolamo; Bernacchia, Giovanni
Source:
Insects 2021 v.12 no.4
ISSN:
2075-4450
Subject:
signal transduction,   etc   ; brain; insects; neurotransmitters; octopamine; pest control; tyramine;     Show all 7 Subjects
Abstract:
... Tyramine is a neuroactive compound that acts as neurotransmitter, neuromodulator, and neurohormone in insects. Three G protein-coupled receptors, TAR1-3, are responsible for mediating the intracellular pathway in the complex tyraminergic network. TAR1, the prominent player in this system, was initially classified as an octopamine receptor which can also be activated by tyramine, while it later app ...
DOI:
10.3390/insects12040315

19. Critically evaluating sweet taste receptor expression and signaling through a molecular pharmacology lens

Author:
Smith, Nicola J.; Grant, Jennifer N.; Moon, Justin I.; So, Sean S.; Finch, Angela M.
Source:
TheFEBS journal 2021 v.288 no.8 pp. 2660-2672
ISSN:
1742-464X
Subject:
signal transduction,   etc   ; pharmacology; sugars; sweetness; taste; taste receptors;     Show all 6 Subjects
Abstract:
... The class C G protein‐coupled sweet taste receptor (STR) is responsible for the perception of sweet‐tasting molecules. Considered an obligate heterodimer, it consists of taste 1 receptor 2 and taste 1 receptor 3 subunits. Interest in the STR has steadily grown, especially since its discovery in extraoral tissues hints at a metabolic role for the receptor. It is now known that many pharmacologicall ...
DOI:
10.1111/febs.15768

20. The cross‐kingdom roles of mineral nutrient transporters in plant‐microbe relations

Author:
Sun, Yuming; Wang, Min; Mur, Luis Alejandro Jose; Shen, Qirong; Guo, Shiwei
Source:
Physiologia plantarum 2021 v.171 no.4 pp. 771-784
ISSN:
0031-9317
Subject:
signal transduction,   etc   ; host plants; mycorrhizae; pathogens; plant physiology; soil;     Show all 6 Subjects
Abstract:
... The regulation of plant physiology by plant mineral nutrient transporter (MNT) is well understood. Recently, the extensive characterization of beneficial and pathogenic plant‐microbe interactions has defined the roles for MNTs in such relationships. In this review, we summarize the roles of diverse nutrient transporters in the symbiotic or pathogenic relationships between plants and microorganisms ...
DOI:
10.1111/ppl.13318