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You searched for: Subject "signal transduction" Remove constraint Subject: "signal transduction"
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1. Aquaporin, beyond a transporter

Author:
Weikun Jing; Yonghong Li; Shuai Zhang; Xiaofeng Zhou; Junping Gao; Nan Ma
Source:
Horticultural plant journal 2022 pp. -
ISSN:
2468-0141
Subject:
signal transduction,   etc   ; aquaporins; homeostasis; horticultural crops;     Show all 4 Subjects
Abstract:
... Aquaporins (AQPs) are one of the most ancient superfamily proteins, which are essential for maintaining the fluid homeostasis of most organisms against various environments. Here, the latest findings for function of AQPs in cell signal transduction in plants are summarized. We also put forward several issues that still need to be addressed in the future. ...
DOI:
10.1016/j.hpj.2022.04.004

2. Structure and Signal Regulation Mechanism of Interspecies and Interkingdom Quorum Sensing System Receptors

Author:
Qingying Fan; Haikun Wang; Chenlong Mao; Jinpeng Li; Xiaoling Zhang; Daniel Grenier; Li Yi; Yang Wang
Source:
Journal of agricultural and food chemistry 2022 v.70 no.2 pp. 429-445
ISSN:
1520-5118
Subject:
signal transduction,   etc   ; food chemistry; host-pathogen relationships;     Show all 3 Subjects
Abstract:
... Quorum sensing (QS) is a signaling mechanism for cell-to-cell communication between bacteria, fungi, and even eukaryotic hosts such as plant and animal cells. Bacteria in real life do not exist as isolated organisms but are found in complex, dynamic, and microecological environments. The study of interspecies QS and interkingdom QS is a valuable approach for exploring bacteria–bacteria interaction ...
DOI:
10.1021/acs.jafc.1c04751

3. New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations

Author:
María Guadalupe Herrera-Hernández; Neda Razzaghi; Pol Fernandez-Gonzalez; Laia Bosch-Presegué; Guillem Vila-Julià; Juan Jesús Pérez; Pere Garriga
Source:
Cellular and molecular life sciences 2022 v.79 no.1 pp. 58
ISSN:
1420-682X
Subject:
signal transduction,   etc   ; mutants; photoreceptors; retinitis pigmentosa; rhodopsin; therapeutics;     Show all 6 Subjects
Abstract:
... Mutations in the photoreceptor protein rhodopsin are known as one of the leading causes of retinal degeneration in humans. Two rhodopsin mutations, Y102H and I307N, obtained in chemically mutagenized mice, are currently the subject of increased interest as relevant models for studying the process of retinal degeneration in humans. Here, we report on the biochemical and functional characterization ...
DOI:
10.1007/s00018-021-04086-0

4. Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions

Author:
Eiru Kim; Lance C. Novak; Chenchu Lin; Medina Colic; Lori L. Bertolet; Veronica Gheorghe; Christopher A. Bristow; Traver Hart
Source:
Genome biology 2022 v.23 no.1 pp. 140
ISSN:
1474-760X
Subject:
signal transduction,   etc   ; bioactive properties; drugs; genotype; mutation; neoplasms; proteinases;     Show all 7 Subjects
Abstract:
... BACKGROUND: Coessentiality networks derived from CRISPR screens in cell lines provide a powerful framework for identifying functional modules in the cell and for inferring the roles of uncharacterized genes. However, these networks integrate signal across all underlying data and can mask strong interactions that occur in only a subset of the cell lines analyzed. RESULTS: Here, we decipher dynamic ...
DOI:
10.1186/s13059-022-02712-z

5. A universal microfluidic approach for integrated analysis of temporal homocellular and heterocellular signaling and migration dynamics

Author:
Haowen Yang; Nidhi Sinha; Ulfert Rand; Hansjörg Hauser; Mario Köster; Tom F.A. de Greef; Jurjen Tel
Source:
Biosensors & bioelectronics 2022 v.211 pp. 114353
ISSN:
0956-5663
Subject:
signal transduction,   etc   ; biosensors; cell movement; coculture; fibroblasts; lipopolysaccharides; microfluidic technology; transactivators;     Show all 8 Subjects
Abstract:
... Microfluidics offers precise and dynamic control of microenvironments for the study of temporal cellular responses. However, recent research focusing solely on either homocellular (single-cell, population) or heterocellular response may yield insufficient output, which possibly leads to partial comprehension about the underlying mechanisms of signaling events and corresponding cellular behaviors. ...
DOI:
10.1016/j.bios.2022.114353

6. Application of dendrimer-based nanosensors in immunodiagnosis

Author:
Sharvari Thakare; Aazam Shaikh; Dhananjay Bodas; Virendra Gajbhiye
Source:
Colloids and surfaces 2022 v.209 pp. 112174
ISSN:
0927-7765
Subject:
signal transduction,   etc   ; antibodies; antigens; biomarkers; cost effectiveness; dendrimers; electrochemistry; immunosensors; serodiagnosis;     Show all 9 Subjects
Abstract:
... Conventional immunoassays such as ELISA and FLISA have been used for clinical diagnosis for a long time. These assays are complex, time-consuming, and uneconomical. They have been overwhelmed with newer and more efficient methods such as electrochemical and electrochemiluminescent immunosensors that are cost-effective and require less time. Immunosensor is a biosensor that consists of a signal tra ...
DOI:
10.1016/j.colsurfb.2021.112174

7. Creativity comes from interactions: modules of protein interactions in plants

Author:
Jeffrey R. Allen; Edward G. Wilkinson; Lucia C. Strader
Source:
FEBS journal 2022 v.289 no.6 pp. 1492-1514
ISSN:
1742-464X
Subject:
signal transduction,   etc   ; amino acids; evolution; oligomerization; peptides; phospholipids; phosphorylation; plant biology;     Show all 8 Subjects
Abstract:
... Protein interactions are the foundation of cell biology. For robust signal transduction to occur, proteins interact selectively and modulate their behavior to direct specific biological outcomes. Frequently, modular protein interaction domains are central to these processes. Some of these domains bind proteins bearing post‐translational modifications, such as phosphorylation, whereas other domains ...
DOI:
10.1111/febs.15847

8. Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte Differentiation

Author:
Seigo Usuki; Noriko Tamura; Tomohiro Tamura; Kohei Yuyama; Daisuke Mikami; Katsuyuki Mukai; Yasuyuki Igarashi
Source:
Biology 2022 v.11 no.1 pp. -
ISSN:
2079-7737
Subject:
signal transduction,   etc   ; Amorphophallus; cell differentiation; cell movement; ceramides; histamine; keratinocytes; phosphorylation;     Show all 8 Subjects
Abstract:
... Histamines suppress epidermal keratinocyte differentiation. Previously, we reported that konjac ceramide (kCer) suppresses histamine-stimulated cell migration of HaCaT keratinocytes. kCer specifically binds to Nrp1 and does not interact with histamine receptors. The signaling mechanism of kCer in HaCaT cells is also controlled by an intracellular signaling cascade activated by the Sema3A-Nrp1 path ...
DOI:
10.3390/biology11010121

9. Molecular reporters for CRISPR/Cas: From design principles to engineering for bioanalytical and diagnostic applications

Author:
Muhammad Sohail; Lingyun Qin; Shuxian Li; Yue Chen; Muhammad Haidar Zaman; Xing Zhang; Bingzhi Li; He Huang
Source:
Trends in analytical chemistry 2022 v.149 pp. 116539
ISSN:
0165-9936
Subject:
signal transduction,   etc   ; analytical chemistry; chemical species; nucleic acids; nucleotide sequences; ribonucleoproteins;     Show all 6 Subjects
Abstract:
... CRISPR/Cas machinery has revolutionized the analytical platform for the precise detection of diverse analytes. Specific target recognition and robust signal transduction are crucial requirements for a superior sensing platform. The signal generation is directly related to the reporter traits in CRISPR/Cas systems. This review illustrated reporter engineering and its significance in improving the C ...
DOI:
10.1016/j.trac.2022.116539

10. Proteomic analysis of Euryale ferox Salisb seeds at different developmental stages

Author:
Peng Wu; AiLian Liu; Yue Zhu; Xiang Li; YuHao Wang; LiangJun Li
Source:
Gene 2022 v.834 pp. 146645
ISSN:
0378-1119
Subject:
signal transduction,   etc   ; Euryale ferox; biosynthesis; flavonoids; genes; proteomics; seed development; starch;     Show all 8 Subjects
Abstract:
... The development of plant seeds is accompanied by changes in their internal substances. The edible part of E. ferox is the seed, and starch and flavonoids are the storage substances and functional substances in E. ferox seeds respectively. Herein, four time points of seed development, including after flowering T10 (10 days), T20 (20 days), T30 (30 days) and T40 (40 days), were investigated by using ...
DOI:
10.1016/j.gene.2022.146645

11. The Role of Peroxiredoxins in the Regulation of Sepsis

Author:
Toshihiko Aki; Kana Unuma; Koichi Uemura
Source:
Antioxidants 2022 v.11 no.1 pp. -
ISSN:
2076-3921
Subject:
signal transduction,   etc   ; homeostasis; hydrogen peroxide; liver; nitrogen; oxidative stress; pathogenesis; peroxiredoxin;     Show all 8 Subjects
Abstract:
... Oxidative stress, a result of a disturbance in redox homeostasis, is considered to be one of the main aggravating events in the pathogenesis of immune disorders. Peroxiredoxins (Prdxs) are an enzyme family that catalyzes the reduction of peroxides, including hydrogen peroxide, lipid peroxides, and nitrogen peroxides. Although the maintenance of cellular redox homeostasis through Prdxs is essential ...
DOI:
10.3390/antiox11010126

12. Deep whole-genome resequencing sheds light on the distribution and effect of amphioxus SNPs

Author:
Yunchi Zhu; Na Lu; J.-Y. Chen; Chunpeng He; Zhen Huang; Zuhong Lu
Source:
BMC genomic data 2022 v.23 no.1 pp. 26
ISSN:
2730-6844
Subject:
signal transduction,   etc   ; cell adhesion; data collection; genomics; haploidy; phenotype; protein structure; vertebrates;     Show all 8 Subjects
Abstract:
... BACKGROUND: Amphioxus is a model organism for vertebrate evolutionary research. The significant contrast between morphological phenotypic similarity and high-level genetic polymorphism among amphioxus populations has aroused scientists' attention. Here we resequenced 21 amphioxus genomes to over 100X depth and mapped them to a haploid reference. RESULTS: More than 11.5 million common SNPs were det ...
DOI:
10.1186/s12863-022-01038-w

13. Identification of Peanut Aux/IAA Genes and Functional Prediction during Seed Development and Maturation

Author:
Xiurong Zhang; Kun Zhang; Lu Luo; Yuying Lv; Yuying Li; Suqing Zhu; Bing Luo; Yongshan Wan; Xiansheng Zhang; Fengzhen Liu
Source:
Plants 2022 v.11 no.4 pp. -
ISSN:
2223-7747
Subject:
signal transduction,   etc   ; germplasm; growth and development; peanuts; plant growth; prediction; seed development;     Show all 7 Subjects
Abstract:
... Auxin-responsive genes AUX/IAA are important during plant growth and development, but there are few relevant reports in peanut. In this study, 44 AhIAA genes were identified from cultivated peanut, of which 31 genes were expressed in seed at varying degrees. AhIAA-3A, AhIAA-16A and AhIAA-15B were up-regulated, while AhIAA-11A, AhIAA-5B and AhIAA-14B were down-regulated with seed development and ma ...
DOI:
10.3390/plants11040472

14. Signal enhancing strategies in aptasensors for the detection of small molecular contaminants by nanomaterials and nucleic acid amplification

Author:
Nan Zhang; Jingrong Li; Boshi Liu; Di Zhang; Chengyu Zhang; Yuheng Guo; Xinhong Chu; Wenting Wang; Haixia Wang; Xiaohui Yan; Zheng Li
Source:
Talanta 2022 v.236 pp. 122866
ISSN:
0039-9140
Subject:
signal transduction,   etc   ; aptasensors; gene amplification; immunogenicity; mycotoxins; oligonucleotides; pesticides; research and development;     Show all 8 Subjects
Abstract:
... Small molecular contaminants (such as mycotoxins, antibiotics, pesticide residues, etc.) in food and environment have given rise to many biological and ecological toxicities, which has attracted worldwide attention in recent years. Meanwhile, due to the advantages of aptamers such as high specificity and stability, easy synthesis and modification, as well as low cost and immunogenicity, various ap ...
DOI:
10.1016/j.talanta.2021.122866

15. Ferroptosis at the intersection of lipid metabolism and cellular signaling

Author:
Deguang Liang; Alexander M. Minikes; Xuejun Jiang
Source:
Molecular cell 2022 v.82 no.12 pp. 2215-2227
ISSN:
1097-2765
Subject:
signal transduction,   etc   ; ferroptosis; immunity; lipid metabolism; necroptosis; neoplasms; neurodegenerative diseases; peroxidation; phospholipids; therapeutics;     Show all 10 Subjects
Abstract:
... Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated to play an important role in multiple diseases including cancer, neurodegeneration, and ischemic organ injury. Mounting evidence also suggests its potential physiological function in tumor suppression and immunity. The execution of ferroptosis is driven by iron-dependent phospholipid peroxidation. As such, th ...
DOI:
10.1016/j.molcel.2022.03.022

16. Genetic Incorporation of Fluorescent Amino Acid into Fatty Acid Binding Protein for Fatty Acid Detection

Author:
Ke Yang; Minling Yu; Xiaolei Zhu; Yan Xia; Fahui Li; Yongze Li; Xiaohong Liu; Jiangyun Wang
Source:
Journal of molecular biology 2022 v.434 no.8 pp. 167498
ISSN:
0022-2836
Subject:
signal transduction,   etc   ; amino acids; energy; fatty acid-binding proteins; fluorescence; metabolism; molecular biology;     Show all 7 Subjects
Abstract:
... Fatty acids play critical roles in biological processes, such as energy storage, metabolism, signal transduction, and immune regulation. Therefore, it is necessary to develop in-vitro fluorescent sensors to detect free fatty acids. By genetically incorporating a synthetic fluorescent amino acid (L-(7-hydroxycoumarin-4-yl) ethylglycine, Cou) into fatty acid-binding protein (FABP), we obtained a flu ...
DOI:
10.1016/j.jmb.2022.167498

17. Quercetin induces lipid domain-dependent permeability

Author:
Natália Bueno Leite; Danubia Batista Martins; Dayane S. Alvares; Marcia Perez dos Santos Cabrera
Source:
Chemistry and physics of lipids 2022 v.242 pp. 105160
ISSN:
0009-3084
Subject:
signal transduction,   etc   ; antioxidant activity; cholesterol; lipid bilayers; mechanism of action; permeability; quercetin; sphingomyelins;     Show all 8 Subjects
Abstract:
... Quercetin is a polyphenolic molecule with a broad spectrum of biological activities derived from its antioxidant property. Its mechanism of action has been explained by its binding and/or interference with enzymes, receptors, transporters and signal transduction systems. Since these important mechanisms generally occur in membrane environments, within and through lipid bilayers, investigating the ...
DOI:
10.1016/j.chemphyslip.2021.105160

18. Selective enrichment tandem β-elimination assisted strategy for N-phosphorylation analysis

Author:
Yechen Hu; Bo Jiang
Source:
Talanta 2022 v.247 pp. 123580
ISSN:
0039-9140
Subject:
signal transduction,   etc   ; Escherichia coli; glucose; landscapes; mass spectrometry; mass transfer; metabolism; microparticles; phosphorylation;     Show all 9 Subjects
Abstract:
... N-phosphorylation modifications are crucial for prokaryotic signal transduction and verified as intermediate for several metabolic enzymes, yet the landscape of N-phosphorylation remains an obstacle due to the lack of effective identification strategies. One of the difficulties derives from the labile phosphoramidate bond (P–N) under acidic conditions, making it easily hydrolyze during the routine ...
DOI:
10.1016/j.talanta.2022.123580

19. Transcriptome analysis in Alcea rosea L. and identification of critical genes involved in stamen petaloid

Author:
Wen Gao; Wei Zheng; Jianming Bai; Wenpo Zhang; Huiling Zhang; Juping Zhang; Zhengjing Wu
Source:
Scientia horticulturae 2022 v.293 pp. 110732
ISSN:
0304-4238
Subject:
signal transduction,   etc   ; Alcea rosea; auxins; brassinosteroids; cytokinins; ethylene; gibberellins; sequence analysis; transcriptomics; unigenes;     Show all 10 Subjects
Abstract:
... This study exploring the molecular mechanism of stamen petaloid development of Alcea rosea L., a popular ornamental of the region, using a comparative transcriptome analysis between multi-petal red flowers (stamen petaloid) and single petal red flowers (no-stamen petaloid) by RNA-seq technology fetched interesting observations. It is found that the 3375 differently expressed unigenes (DEGs), out o ...
DOI:
10.1016/j.scienta.2021.110732

20. A quantitative sensing system based on a 3D-printed ion-selective electrode for rapid and sensitive detection of bacteria in biological fluid

Author:
Tao Zhang; Giraso Keza Monia Kabandana; Adam Michael Ratajczak; Chengpeng Chen
Source:
Talanta 2022 v.238 pp. 123040
ISSN:
0039-9140
Subject:
signal transduction,   etc   ; potentiometers; specific ion electrodes; three-dimensional printing; urinary tract; urinary tract diseases;     Show all 6 Subjects
Abstract:
... Bacterial infections, such as urinary tract infections, are crucial health problems. Here, we report a new potentiometric sensor to detect bacteria sensitively, accurately, and quickly. First, a customizable, 3D printed Ag⁺ selective electrode was fabricated as the probe. Our 3D printed electrode showed sensitive, linear, and selective responses to Ag⁺. Compared to commercial Ag⁺ selective electro ...
DOI:
10.1016/j.talanta.2021.123040