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signaltransduction, etc ; aquaporins; homeostasis; horticultural crops; Show all 4 Subjects
Abstract:
... Aquaporins (AQPs) are one of the most ancient superfamily proteins, which are essential for maintaining the fluid homeostasis of most organisms against various environments. Here, the latest findings for function of AQPs in cell signal transduction in plants are summarized. We also put forward several issues that still need to be addressed in the future. ...
signaltransduction, etc ; food chemistry; host-pathogen relationships; Show all 3 Subjects
Abstract:
... Quorum sensing (QS) is a signaling mechanism for cell-to-cell communication between bacteria, fungi, and even eukaryotic hosts such as plant and animal cells. Bacteria in real life do not exist as isolated organisms but are found in complex, dynamic, and microecological environments. The study of interspecies QS and interkingdom QS is a valuable approach for exploring bacteria–bacteria interaction ...
signaltransduction, etc ; mutants; photoreceptors; retinitis pigmentosa; rhodopsin; therapeutics; Show all 6 Subjects
Abstract:
... Mutations in the photoreceptor protein rhodopsin are known as one of the leading causes of retinal degeneration in humans. Two rhodopsin mutations, Y102H and I307N, obtained in chemically mutagenized mice, are currently the subject of increased interest as relevant models for studying the process of retinal degeneration in humans. Here, we report on the biochemical and functional characterization ...
signaltransduction, etc ; bioactive properties; drugs; genotype; mutation; neoplasms; proteinases; Show all 7 Subjects
Abstract:
... BACKGROUND: Coessentiality networks derived from CRISPR screens in cell lines provide a powerful framework for identifying functional modules in the cell and for inferring the roles of uncharacterized genes. However, these networks integrate signal across all underlying data and can mask strong interactions that occur in only a subset of the cell lines analyzed. RESULTS: Here, we decipher dynamic ...
signaltransduction, etc ; biosensors; cell movement; coculture; fibroblasts; lipopolysaccharides; microfluidic technology; transactivators; Show all 8 Subjects
Abstract:
... Microfluidics offers precise and dynamic control of microenvironments for the study of temporal cellular responses. However, recent research focusing solely on either homocellular (single-cell, population) or heterocellular response may yield insufficient output, which possibly leads to partial comprehension about the underlying mechanisms of signaling events and corresponding cellular behaviors. ...
signaltransduction, etc ; antibodies; antigens; biomarkers; cost effectiveness; dendrimers; electrochemistry; immunosensors; serodiagnosis; Show all 9 Subjects
Abstract:
... Conventional immunoassays such as ELISA and FLISA have been used for clinical diagnosis for a long time. These assays are complex, time-consuming, and uneconomical. They have been overwhelmed with newer and more efficient methods such as electrochemical and electrochemiluminescent immunosensors that are cost-effective and require less time. Immunosensor is a biosensor that consists of a signal tra ...
signaltransduction, etc ; amino acids; evolution; oligomerization; peptides; phospholipids; phosphorylation; plant biology; Show all 8 Subjects
Abstract:
... Protein interactions are the foundation of cell biology. For robust signal transduction to occur, proteins interact selectively and modulate their behavior to direct specific biological outcomes. Frequently, modular protein interaction domains are central to these processes. Some of these domains bind proteins bearing post‐translational modifications, such as phosphorylation, whereas other domains ...
signaltransduction, etc ; Amorphophallus; cell differentiation; cell movement; ceramides; histamine; keratinocytes; phosphorylation; Show all 8 Subjects
Abstract:
... Histamines suppress epidermal keratinocyte differentiation. Previously, we reported that konjac ceramide (kCer) suppresses histamine-stimulated cell migration of HaCaT keratinocytes. kCer specifically binds to Nrp1 and does not interact with histamine receptors. The signaling mechanism of kCer in HaCaT cells is also controlled by an intracellular signaling cascade activated by the Sema3A-Nrp1 path ...
signaltransduction, etc ; analytical chemistry; chemical species; nucleic acids; nucleotide sequences; ribonucleoproteins; Show all 6 Subjects
Abstract:
... CRISPR/Cas machinery has revolutionized the analytical platform for the precise detection of diverse analytes. Specific target recognition and robust signal transduction are crucial requirements for a superior sensing platform. The signal generation is directly related to the reporter traits in CRISPR/Cas systems. This review illustrated reporter engineering and its significance in improving the C ...
signaltransduction, etc ; Euryale ferox; biosynthesis; flavonoids; genes; proteomics; seed development; starch; Show all 8 Subjects
Abstract:
... The development of plant seeds is accompanied by changes in their internal substances. The edible part of E. ferox is the seed, and starch and flavonoids are the storage substances and functional substances in E. ferox seeds respectively. Herein, four time points of seed development, including after flowering T10 (10 days), T20 (20 days), T30 (30 days) and T40 (40 days), were investigated by using ...
signaltransduction, etc ; homeostasis; hydrogen peroxide; liver; nitrogen; oxidative stress; pathogenesis; peroxiredoxin; Show all 8 Subjects
Abstract:
... Oxidative stress, a result of a disturbance in redox homeostasis, is considered to be one of the main aggravating events in the pathogenesis of immune disorders. Peroxiredoxins (Prdxs) are an enzyme family that catalyzes the reduction of peroxides, including hydrogen peroxide, lipid peroxides, and nitrogen peroxides. Although the maintenance of cellular redox homeostasis through Prdxs is essential ...
signaltransduction, etc ; cell adhesion; data collection; genomics; haploidy; phenotype; protein structure; vertebrates; Show all 8 Subjects
Abstract:
... BACKGROUND: Amphioxus is a model organism for vertebrate evolutionary research. The significant contrast between morphological phenotypic similarity and high-level genetic polymorphism among amphioxus populations has aroused scientists' attention. Here we resequenced 21 amphioxus genomes to over 100X depth and mapped them to a haploid reference. RESULTS: More than 11.5 million common SNPs were det ...
signaltransduction, etc ; germplasm; growth and development; peanuts; plant growth; prediction; seed development; Show all 7 Subjects
Abstract:
... Auxin-responsive genes AUX/IAA are important during plant growth and development, but there are few relevant reports in peanut. In this study, 44 AhIAA genes were identified from cultivated peanut, of which 31 genes were expressed in seed at varying degrees. AhIAA-3A, AhIAA-16A and AhIAA-15B were up-regulated, while AhIAA-11A, AhIAA-5B and AhIAA-14B were down-regulated with seed development and ma ...
signaltransduction, etc ; aptasensors; gene amplification; immunogenicity; mycotoxins; oligonucleotides; pesticides; research and development; Show all 8 Subjects
Abstract:
... Small molecular contaminants (such as mycotoxins, antibiotics, pesticide residues, etc.) in food and environment have given rise to many biological and ecological toxicities, which has attracted worldwide attention in recent years. Meanwhile, due to the advantages of aptamers such as high specificity and stability, easy synthesis and modification, as well as low cost and immunogenicity, various ap ...
signaltransduction, etc ; ferroptosis; immunity; lipid metabolism; necroptosis; neoplasms; neurodegenerative diseases; peroxidation; phospholipids; therapeutics; Show all 10 Subjects
Abstract:
... Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated to play an important role in multiple diseases including cancer, neurodegeneration, and ischemic organ injury. Mounting evidence also suggests its potential physiological function in tumor suppression and immunity. The execution of ferroptosis is driven by iron-dependent phospholipid peroxidation. As such, th ...
signaltransduction, etc ; amino acids; energy; fatty acid-binding proteins; fluorescence; metabolism; molecular biology; Show all 7 Subjects
Abstract:
... Fatty acids play critical roles in biological processes, such as energy storage, metabolism, signal transduction, and immune regulation. Therefore, it is necessary to develop in-vitro fluorescent sensors to detect free fatty acids. By genetically incorporating a synthetic fluorescent amino acid (L-(7-hydroxycoumarin-4-yl) ethylglycine, Cou) into fatty acid-binding protein (FABP), we obtained a flu ...
signaltransduction, etc ; antioxidant activity; cholesterol; lipid bilayers; mechanism of action; permeability; quercetin; sphingomyelins; Show all 8 Subjects
Abstract:
... Quercetin is a polyphenolic molecule with a broad spectrum of biological activities derived from its antioxidant property. Its mechanism of action has been explained by its binding and/or interference with enzymes, receptors, transporters and signal transduction systems. Since these important mechanisms generally occur in membrane environments, within and through lipid bilayers, investigating the ...
signaltransduction, etc ; Escherichia coli; glucose; landscapes; mass spectrometry; mass transfer; metabolism; microparticles; phosphorylation; Show all 9 Subjects
Abstract:
... N-phosphorylation modifications are crucial for prokaryotic signal transduction and verified as intermediate for several metabolic enzymes, yet the landscape of N-phosphorylation remains an obstacle due to the lack of effective identification strategies. One of the difficulties derives from the labile phosphoramidate bond (P–N) under acidic conditions, making it easily hydrolyze during the routine ...
signaltransduction, etc ; Alcea rosea; auxins; brassinosteroids; cytokinins; ethylene; gibberellins; sequence analysis; transcriptomics; unigenes; Show all 10 Subjects
Abstract:
... This study exploring the molecular mechanism of stamen petaloid development of Alcea rosea L., a popular ornamental of the region, using a comparative transcriptome analysis between multi-petal red flowers (stamen petaloid) and single petal red flowers (no-stamen petaloid) by RNA-seq technology fetched interesting observations. It is found that the 3375 differently expressed unigenes (DEGs), out o ...
signaltransduction, etc ; potentiometers; specific ion electrodes; three-dimensional printing; urinary tract; urinary tract diseases; Show all 6 Subjects
Abstract:
... Bacterial infections, such as urinary tract infections, are crucial health problems. Here, we report a new potentiometric sensor to detect bacteria sensitively, accurately, and quickly. First, a customizable, 3D printed Ag⁺ selective electrode was fabricated as the probe. Our 3D printed electrode showed sensitive, linear, and selective responses to Ag⁺. Compared to commercial Ag⁺ selective electro ...