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1. Long-term resveratrol treatment improves the capillarization in the skeletal muscles of ageing C57BL/6J mice

Author:
Toniolo, Luana; Formoso, Luca; Torelli, Lucio; Crea, Emanuela; Bergamo, Alberta; Sava, Gianni; Giacomello, Emiliana
Source:
International journal of food sciences and nutrition 2021 v.72 no.1 pp. 37-44
ISSN:
1465-3478
Subject:
skeletal muscle,   etc   ; diet; males; resveratrol;     Show all 4 Subjects
Abstract:
... We recently showed that the treatment with Resveratrol (RES) contrasts the effects of ageing on the skeletal muscle (SKM), reduces the appearance of tubular aggregates (TAs), and improves the fatigue resistance. Since fatigue resistance depends on the SKM capillary network, and RES has been described to improve vascularisation, we analysed the SKM capillarization in naturally ageing C57BL/6J male ...
DOI:
10.1080/09637486.2020.1769569

2. Nutrition and Muscle Recovery

Author:
Mielgo-Ayuso, Juan; Fernández-Lázaro, Diego
Source:
Nutrients 2021 v.13 no.2
ISSN:
2072-6643
Subject:
skeletal muscle,   etc   ; exercise; histopathology; muscles; nutrition;     Show all 5 Subjects
Abstract:
... Exercise-induced muscle damage (EIMD) is characterized by histopathological muscle tissue changes that originate skeletal muscle damage [...] ...
DOI:
10.3390/nu13020294

3. ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells

Author:
Ma, Li; Li, Chengxu; Lian, Shuai; Xu, Bin; Yuan, Jianbin; Lu, Jingjing; Yang, Huanmin; Guo, Jingru; Ji, Hong
Source:
Molecular and cellular endocrinology 2021 v.519 pp. 111055
ISSN:
0303-7207
Subject:
skeletal muscle,   etc   ; endocrinology; humans; interphase; mice; myoblasts;     Show all 6 Subjects
Abstract:
... The myoblast is a precursor cell that rebuilds muscle tissue after trauma in human and animal skeletal muscle tissue. Proliferation of myoblasts is important for skeletal muscle damage repair and is controlled by numerous transcription factors and signals. The regulation of these signaling pathways and their complex interactions are not fully understood. This study aims to determine the physiologi ...
DOI:
10.1016/j.mce.2020.111055

4. 3D in vitro models of skeletal muscle: myopshere, myobundle and bioprinted muscle construct

Author:
Dessauge, Frederic; Schleder, Cindy; Perruchot, Marie-Hélène; Rouger, Karl
Source:
Veterinary research 2021 v.52 no.1 pp. 72
ISSN:
1297-9716
Subject:
skeletal muscle,   etc   ; biomimetics; bioprinting; coculture; models; muscles; veterinary medicine;     Show all 7 Subjects
Abstract:
... Typical two-dimensional (2D) culture models of skeletal muscle-derived cells cannot fully recapitulate the organization and function of living muscle tissues, restricting their usefulness in in-depth physiological studies. The development of functional 3D culture models offers a major opportunity to mimic the living tissues and to model muscle diseases. In this respect, this new type of in vitro m ...
DOI:
10.1186/s13567-021-00942-w

5. Approaches to characterize the transcriptional trajectory of human myogenesis

Author:
Lim, HoTae; Choi, In Young; Hyun, Sang-Hwan; Kim, Hyesoo; Lee, Gabsang
Source:
Cellular and molecular life sciences 2021 v.78 no.9 pp. 4221-4234
ISSN:
1420-682X
Subject:
skeletal muscle,   etc   ; genes; humans; models; muscle development; transcription (genetics);     Show all 6 Subjects
Abstract:
... Human pluripotent stem cells (hPSCs) have attracted considerable interest in understanding the cellular fate determination processes and modeling a number of intractable diseases. In vitro generation of skeletal muscle tissues using hPSCs provides an essential model to identify the molecular functions and gene regulatory networks controlling the differentiation of skeletal muscle progenitor cells. ...
DOI:
10.1007/s00018-021-03782-1

6. Mitochondrial network remodeling: an important feature of myogenesis and skeletal muscle regeneration

Author:
Rahman, Fasih Ahmad; Quadrilatero, Joe
Source:
Cellular and molecular life sciences 2021 v.78 no.10 pp. 4653-4675
ISSN:
1420-682X
Subject:
skeletal muscle,   etc   ; biogenesis; homeostasis; mitochondria; mitophagy; muscle development;     Show all 6 Subjects
Abstract:
... The remodeling of the mitochondrial network is a critical process in maintaining cellular homeostasis and is intimately related to mitochondrial function. The interplay between the formation of new mitochondria (biogenesis) and the removal of damaged mitochondria (mitophagy) provide a means for the repopulation of the mitochondrial network. Additionally, mitochondrial fission and fusion serve as a ...
DOI:
10.1007/s00018-021-03807-9

7. The lifecycle of skeletal muscle mitochondria in obesity

Author:
Pileggi, Chantal A.; Parmar, Gaganvir; Harper, Mary‐Ellen
Source:
Obesity reviews 2021 v.22 no.5 pp. e13164
ISSN:
1467-7881
Subject:
skeletal muscle,   etc   ; biogenesis; energy; macroautophagy; metabolism; mitochondria; mitophagy; obesity;     Show all 8 Subjects
Abstract:
... Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation in cellular energy transduction to meet the demands of the organism. Obesity elicits changes in skeletal muscle structure and function, resulting in the accumulation of intramuscular lipids. The accumulation of intramuscular lipids in obesity is associated with impaired skeletal muscle mitochondrial conten ...
DOI:
10.1111/obr.13164

8. The molecular basis for sarcomere organization in vertebrate skeletal muscle

Author:
Wang, Zhexin; Grange, Michael; Wagner, Thorsten; Kho, Ay Lin; Gautel, Mathias; Raunser, Stefan
Source:
Cell 2021 v.184 no.8 pp. 2135-2150.e13
ISSN:
0092-8674
Subject:
skeletal muscle,   etc   ; actin; crosslinking; myosin; sarcomeres; tropomyosins; vertebrates;     Show all 7 Subjects
Abstract:
... Sarcomeres are force-generating and load-bearing devices of muscles. A precise molecular picture of how sarcomeres are built underpins understanding their role in health and disease. Here, we determine the molecular architecture of native vertebrate skeletal sarcomeres by electron cryo-tomography. Our reconstruction reveals molecular details of the three-dimensional organization and interaction of ...
DOI:
10.1016/j.cell.2021.02.047

9. Apoptotic response to acute and chronic exercises in rat skeletal muscle: Eccentric & sprint interval

Author:
Azad, Milad; Khaledi, Neda; Hedayati, Mehdi; Karbalaie, Mohammadreza
Source:
Life sciences 2021 v.270 pp. 119002
ISSN:
0024-3205
Subject:
skeletal muscle,   etc   ; apoptosis; exercise; gene expression; homeostasis; muscles; rats;     Show all 7 Subjects
Abstract:
... Apoptosis is a type of cell death that is vital for tissue homeostasis. Exercise can lead to initial stimulation of apoptotic regulator genes. We investigated their response to an acute exercise and their adaptations to chronic exercise training with an emphasis on eccentric and sprint interval exercises.Male Sprague Dawley rats were randomly assigned to five groups (n = 8): acute eccentric exerci ...
DOI:
10.1016/j.lfs.2020.119002

10. miR-22-3p regulates muscle fiber-type conversion through inhibiting AMPK/SIRT1/PGC-1α pathway

Author:
Wen, Wanxue; Chen, Xiaoling; Huang, Zhiqing; Chen, Daiwen; Zheng, Ping; He, Jun; Chen, Hong; Yu, Jie; Luo, Yuheng; Yu, Bing
Source:
Animal biotechnology 2021 v.32 no.2 pp. 254-261
ISSN:
1532-2378
Subject:
skeletal muscle,   etc   ; animals; biotechnology; microRNA; muscles; myosin heavy chains; myotubes;     Show all 7 Subjects
Abstract:
... MicroRNAs (miRNAs) are a class of conserved non-coding RNAs that are widely regarded as important regulators in a variety of biological processes. Increasing evidence has revealed that skeletal muscle fiber-type conversion is regulated by miRNAs, but the molecular mechanism is still not fully understood. In this study, we confirmed the role of miR-22-3p on skeletal muscle fiber-type conversion and ...
DOI:
10.1080/10495398.2020.1763375

11. Construction of fluorescent rotors with multiple intramolecular rotation sites for visualization of cellular viscous compartments with elevated fidelity

Author:
Hao, Qiuhua; Li, Chuanya; Niu, Jie; Yang, Rui; Yu, Xiaoqiang
Source:
Analytical methods 2021 v.13 no.9 pp. 1132-1137
ISSN:
1759-9679
Subject:
skeletal muscle,   etc   ; bioimaging; fluorescence; liver; mitochondria; myocardium; plasma membrane; viscosity;     Show all 8 Subjects
Abstract:
... Viscosity-sensitive fluorescent dyes are widely utilized to image viscous intracellular compartments with high fidelity. However, the sensitivity of many fluorescent rotors needs improvement for bioimaging applications. Herein, we proposed to construct a fluorescent rotor with multiple intramolecular rotation sites to elevate its sensitivity to environmental viscosity. The fabricated fluorescent r ...
DOI:
10.1039/d0ay02247k

12. Function and Fiber-Type Specific Distribution of Hsp60 and αB-Crystallin in Skeletal Muscles: Role of Physical Exercise

Author:
D’Amico, Daniela; Fiore, Roberto; Caporossi, Daniela; Di Felice, Valentina; Cappello, Francesco; Dimauro, Ivan; Barone, Rosario
Source:
Biology 2021 v.10 no.2
ISSN:
2079-7737
Subject:
skeletal muscle,   etc   ; exercise; heat stress; homeostasis; hypertrophy; mechanical stress; mitochondria;     Show all 7 Subjects
Abstract:
... Skeletal muscle is a plastic and complex tissue, rich in proteins that are subject to continuous rearrangements. Skeletal muscle homeostasis can be affected by different types of stresses, including physical activity, a physiological stressor able to stimulate a robust increase in different heat shock proteins (HSPs). The modulation of these proteins appears to be fundamental in facilitating the c ...
DOI:
10.3390/biology10020077

13. Effects of myopathy-causing mutations R91P and R245G in the TPM3 gene on structural and functional properties of slow skeletal muscle tropomyosin

Author:
Gonchar, Anastasiia D.; Kopylova, Galina V.; Kochurova, Anastasia M.; Berg, Valentina Y.; Shchepkin, Daniil V.; Koubasova, Natalia A.; Tsaturyan, Andrey K.; Kleymenov, Sergey Y.; Matyushenko, Alexander M.; Levitsky, Dmitrii I.
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 8-13
ISSN:
0006-291X
Subject:
skeletal muscle,   etc   ; genes; genetic disorders; muscle contraction; muscles; research; tropomyosins;     Show all 7 Subjects
Abstract:
... Tropomyosin (Tpm) is an actin-binding protein that plays a crucial role in the regulation of muscle contraction. Numerous point mutations in the TPM3 gene encoding Tpm of slow skeletal muscles (Tpm 3.12 or γ-Tpm) are associated with the genesis of various congenital myopathies. Two of these mutations, R91P and R245G, are associated with congenital fiber-type disproportion (CFTD) characterized by h ...
DOI:
10.1016/j.bbrc.2020.11.103

14. Reduced membrane cholesterol content in skeletal muscle is not essential for greater insulin-stimulated glucose uptake after acute exercise by rats

Author:
Wang, Haiyan; Arias, Edward B.; Cartee, Gregory D.
Source:
Applied physiology, nutrition and metabolism 2021 v.46 no.6 pp. 685-689
ISSN:
1715-5320
Subject:
skeletal muscle,   etc   ; cholesterol; exercise; glucose; metabolism; muscles; nutrition; phosphorylation;     Show all 8 Subjects
Abstract:
... One exercise session can elevate insulin-stimulated glucose uptake (GU) by skeletal muscle, but it is uncertain if this effect is accompanied by altered membrane cholesterol content, which is reportedly inversely related to insulin-stimulated GU. Muscles from sedentary (SED) or exercised 3 h post-exercise (3hPEX) rats were evaluated for GU, membrane cholesterol, and phosphorylation of cholesterol ...
DOI:
10.1139/apnm-2021-0130

15. Disease-associated metabolic alterations that impact satellite cells and muscle regeneration: perspectives and therapeutic outlook

Author:
Joseph, Josiane; Doles, Jason D.
Source:
Nutrition & metabolism 2021 v.18 no.1 pp. 33
ISSN:
1743-7075
Subject:
skeletal muscle,   etc   ; chronic diseases; muscle development; muscles; nutrition; protein metabolism; stem cells; therapeutics;     Show all 8 Subjects
Abstract:
... Many chronic disease patients experience a concurrent loss of lean muscle mass. Skeletal muscle is a dynamic tissue maintained by continuous protein turnover and progenitor cell activity. Muscle stem cells, or satellite cells, differentiate (by a process called myogenesis) and fuse to repair and regenerate muscle. During myogenesis, satellite cells undergo extensive metabolic alterations; therefor ...
DOI:
10.1186/s12986-021-00565-0

16. Skeletal muscle metabolism on whole-body positron emission tomography during pitching

Author:
Takata, Yasushi; Nakase, Junsuke; Inaki, Anri; Mochizuki, Takafumi; Shimozaki, Kengo; Asai, Kazuki; Kinuya, Seigo; Tsuchiya, Hiroyuki
Source:
Journal of the International Society of Sports Nutrition 2021 v.18 no.1 pp. 21
ISSN:
1550-2783
Subject:
skeletal muscle,   etc   ; adults; electromyography; electrons; glucose; intravenous injection; metabolism; muscles; positron-emission tomography; t-test;     Show all 10 Subjects
Abstract:
... BACKGROUND: Electromyography (EMG) has been used for evaluating skeletal muscle activity during pitching. However, it is difficult to observe the influence of movement on skeletal muscle activity in deep-lying regions of the trunk and extremities using EMG. An alternative method that may be used is the measurement of glucose metabolism of skeletal muscle using positron emission tomography-computed ...
DOI:
10.1186/s12970-021-00418-4

17. The role of protein hydrolysates for exercise-induced skeletal muscle recovery and adaptation: a current perspective

Author:
Morgan, Paul T.; Breen, Leigh
Source:
Nutrition & metabolism 2021 v.18 no.1 pp. 44
ISSN:
1743-7075
Subject:
skeletal muscle,   etc   ; exercise; hydrolysis; markets; muscle protein; muscles; protein supplements; protein synthesis;     Show all 8 Subjects
Abstract:
... The protein supplement industry is expanding rapidly and estimated to have a multi-billion market worth. Recent research has centred on understanding how the manufacturing processes of protein supplements may impact muscle recovery and remodeling. The hydrolysed forms of protein undergo a further heating extraction process during production which may contribute to amino acids (AA) appearing in cir ...
DOI:
10.1186/s12986-021-00574-z

18. Variation of skeletal muscle ultrasound imaging intensity in horses after treadmill exercise: a proof of concept for glycogen content estimation

Author:
Tabozzi, Sarah A.; Stancari, Giovanni; Zucca, Enrica; Tajoli, Michela; Stucchi, Luca; Lafortuna, Claudio L.; Ferrucci, Francesco
Source:
BMC veterinary research 2021 v.17 no.1 pp. 121
ISSN:
1746-6148
Subject:
skeletal muscle,   etc   ; biopsy; energy; exercise; glycogen; heart rate; humans; muscles; ultrasonics; veterinary medicine;     Show all 10 Subjects
Abstract:
... BACKGROUND: Glycogen in skeletal muscle is a major source of energy during exercise and an important determinant of endurance capacity, so that its measurement may provide a meaningful marker of athletes’ preparation and a possible predictor of performance, both in humans and in equines. Gold standard of glycogen concentration measurement is the histochemical and biochemical analysis of biopsy-der ...
DOI:
10.1186/s12917-021-02818-9

19. Effects of ketoanalogues on skeletal muscle mass in patients with advanced chronic kidney disease: real-world evidence

Author:
Lin, Yu-Li; Hou, Jia-Sian; Wang, Chih-Hsien; Su, Chen-Ying; Liou, Hung-Hsiang; Hsu, Bang-Gee
Source:
Nutrition 2021 v.91-92 pp. 111384
ISSN:
0899-9007
Subject:
skeletal muscle,   etc   ; bioelectrical impedance; body fat; diet; elderly; kidney diseases; nutritional status; observational studies;     Show all 8 Subjects
Abstract:
... Ketoanalogue (KA) supplementation in patients with chronic kidney disease (CKD) on a restricted protein diet has been shown to maintain their nutritional status in clinical trials. However, a gap existed between the findings of the clinical trials and the real-world practice. The aim of this prospective observational study was to evaluate the KA effect on skeletal muscle mass in patients with stag ...
DOI:
10.1016/j.nut.2021.111384

20. Improvement of skeletal muscle growth by GH/IGF growth-axis contributes to growth performance in commercial fleshy sturgeon

Author:
Yang, Shiyong; Liu, Zhao; Yan, Zhaozhan; Zhao, Zhongmeng; Zhang, Chaoyang; Gong, Quan; Du, Xiaogang; Wu, Jiayun; Feng, Yang; Du, Jun; Huang, Xiaoli
Source:
Aquaculture 2021 v.543 pp. 736929
ISSN:
0044-8486
Subject:
skeletal muscle,   etc   ; aquaculture; aquaculture industry; arginine; genes; growth performance; hybrids; metabolism; somatomedins; somatotropin; sturgeon; transcriptomics;     Show all 12 Subjects
Abstract:
... As the most trait of commercial fish, increasing the growth rate of skeletal muscle is of great significance to aquaculture industry. However, the regulation of growth hormone/somatomedin (GH/IGF) growth-axis on skeletal muscle has not been effectively applied for many years, and its effect on fish and production significance for aquaculture need to be further studied. This study investigated the ...
DOI:
10.1016/j.aquaculture.2021.736929