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You searched for: Subject "skeletal muscle" Remove constraint Subject: "skeletal muscle"
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1. Generation of fast growth Nile tilapia (Oreochromis niloticus) by myostatin gene mutation

Author:
You Wu; Tengfei Wu; Lanying Yang; Yun Su; Chenhua Zhao; Lu Li; Jing Cai; Xiangyan Dai; Deshou Wang; Linyan Zhou
Source:
Aquaculture 2023 v.562 pp. 738762
ISSN:
0044-8486
Subject:
skeletal muscle,   etc   ; CRISPR-Cas systems; Oreochromis niloticus; aquaculture; basement membrane; body size; body weight; brain; carp; condition factor; fins; fluorescence; gene expression; genes; growth performance; head; hybridization; males; mammals; muscles; mutants; mutation; myostatin; phenotype; phylogeny; sexual dimorphism; specific growth rate; weight gain;     Show all 28 Subjects
Abstract:
... Tilapia is the second most prolific species grown in aquaculture after carp, and is widely grown in >100 countries. Myostatin (MSTN) has been proved to be a negative regulator of skeletal muscle growth. Mutation of MSTN gene resulted in significant increase in both body size and muscle mass in vertebrates, mostly with a species-specific effect. To generate a new strain in Nile tilapia (Oreochromis ...
DOI:
10.1016/j.aquaculture.2022.738762

2. Oxidative Stress in Skeletal Muscle

Author:
Giorgio Fanò-Illic; Stefania Fulle
Source:
Antioxidants 2022 v.11 no.7 pp. -
ISSN:
2076-3921
Subject:
skeletal muscle,   etc   ; mitochondria; muscles; oxidative stress;     Show all 4 Subjects
Abstract:
... The accumulation of ROS, mainly due to increased mitochondrial production and/or decreased scavenger systems, is often associated with the term oxidative stress, used to define a condition judged to be problematic for muscle cells [...] ...
DOI:
10.3390/antiox11071299

3. SnapShot: Skeletal muscle atrophy

Author:
Leslie M. Baehr; David C. Hughes; David S. Waddell; Sue C. Bodine
Source:
Cell 2022 v.185 no.9 pp. 1618
ISSN:
0092-8674
Subject:
skeletal muscle,   etc   ; muscular atrophy; protein synthesis;     Show all 3 Subjects
Abstract:
... Skeletal muscle size is highly plastic and sensitive to a variety of stimuli. Muscle atrophy occurs as the result of changes in multiple signaling pathways that regulate both protein synthesis and degradation. The signaling pathways that are activated or inhibited depend on the specific stimuli that are altered. To view this SnapShot, open of download the PDF. ...
DOI:
10.1016/j.cell.2022.03.028

4. Ablation of Ghrelin Receptor Mitigates the Metabolic Decline of Aging Skeletal Muscle

Author:
Colleen O’Reilly; Ligen Lin; Hongying Wang; James Fluckey; Yuxiang Sun
Source:
Genes 2022 v.13 no.8 pp. -
ISSN:
2073-4425
Subject:
skeletal muscle,   etc   ; ghrelin; ghrelin receptors; metabolism; muscles;     Show all 5 Subjects
Abstract:
... The orexigenic hormone ghrelin has multifaceted roles in health and disease. We have reported that ablation of the ghrelin receptor, growth hormone secretagogue receptor (GHS-R), protects against metabolic dysfunction of adipose tissues in aging. Our further observation interestingly revealed that GHS-R deficiency phenocopies the effects of myokine irisin. In this study, we aim to determine whethe ...
DOI:
10.3390/genes13081368

5. Tandem repeats ubiquitously flank and contribute to translation initiation sites

Author:
Ali M. A. Maddi; Kaveh Kavousi; Masoud Arabfard; Hamid Ohadi; Mina Ohadi
Source:
BMC genomic data 2022 v.23 no.1 pp. 59
ISSN:
2730-6844
Subject:
skeletal muscle,   etc   ; brain; divergent evolution; genomics; humans;     Show all 5 Subjects
Abstract:
... BACKGROUND: While the evolutionary divergence of cis-regulatory sequences impacts translation initiation sites (TISs), the implication of tandem repeats (TRs) in TIS selection remains largely elusive. Here, we employed the TIS homology concept to study a possible link between TRs of all core lengths and repeats with TISs. METHODS: Human, as reference sequence, and 83 other species were selected, a ...
DOI:
10.1186/s12863-022-01075-5

6. Pre-clinical research studies for treating severe muscular injuries: focus on tissue-engineered strategies

Author:
Omar Alheib; Lucília P. da Silva; Il Keun Kwon; Rui L. Reis; Vitor M. Correlo
Source:
Trends in biotechnology 2022 pp. -
ISSN:
0167-7799
Subject:
skeletal muscle,   etc   ; biocompatible materials; biotechnology; muscles; therapeutics;     Show all 5 Subjects
Abstract:
... Severe skeletal muscle injuries are a lifelong trauma with limited medical solutions. Significant progress has been made in developing in vitro surrogates for treating these traumas. However, more attention is needed when translating these approaches to the clinic. In this review, we survey the potential of tissue-engineered surrogates in promoting muscle healing, by critically analyzing data from ...
DOI:
10.1016/j.tibtech.2022.09.010

7. Validation of the Italian Version of the SARC-F Questionnaire to Assess Sarcopenia in Older Adults

Author:
Simone Perna; Clara Gasparri; Cinzia Ferraris; Gaetan Claude Barrile; Alessandro Cavioni; Francesca Mansueto; Zaira Patelli; Gabriella Peroni; Alice Tartara; Marco Zese; Mariangela Rondanelli
Source:
Nutrients 2022 v.14 no.12 pp. -
ISSN:
2072-6643
Subject:
skeletal muscle,   etc   ; elderly; females; males; questionnaires; sarcopenia;     Show all 6 Subjects
Abstract:
... Background: SARC-F is a simple sarcopenia screening tool. This study aimed to examine the validity of the Italian version of SARC-F. Methods: A total of 97 elderly individuals (37/60 males/females, 65 years and older) who met the study’s selection criteria were included. SARC-F was translated into the Italian language in a culturally responsive manner. The total score was calculated by adding the ...
DOI:
10.3390/nu14122533

8. Disruption of Hfe leads to skeletal muscle iron loading and reduction of hemoproteins involved in oxidative metabolism in a mouse model of hereditary hemochromatosis

Author:
Francesca M. Alves; Marissa K. Caldow; Sheridan L. Helman; Scott Ayton; Ashley I. Bush; Gordon S. Lynch; David M. Frazer; René Koopman
Source:
Biochimica et biophysica acta 2022 v.1866 no.3 pp. 130082
ISSN:
0304-4165
Subject:
skeletal muscle,   etc   ; aerobiosis; exercise; hemochromatosis; iron; mice; myoglobin;     Show all 7 Subjects
Abstract:
... •Hereditary hemochromatosis (HH) is a common iron loading condition often associated with fatigue and reduced exercise tolerance, although the biochemical changes causing these symptoms are unclear.•We investigated the effect of HH on skeletal muscles of aged mice.•We show that HH in mice is associated with increased skeletal muscle iron and a reduction in proteins associated with oxidative metabo ...
DOI:
10.1016/j.bbagen.2021.130082

9. The Contribution of Genetics to Muscle Disuse, Retraining, and Aging

Author:
Giuseppe Sirago; Anna Picca; Emiliana Giacomello; Emanuele Marzetti; Luana Toniolo
Source:
Genes 2022 v.13 no.8 pp. -
ISSN:
2073-4425
Subject:
skeletal muscle,   etc   ; genetic background; genetics; muscles; muscular atrophy;     Show all 5 Subjects
Abstract:
... Genetic background may partly explain differences in muscle responses to internal or external stimuli. Muscle disuse involves various degrees of skeletal muscle atrophy due to inactivity and mechanical unloading. Whether and to which extent genetic background impacts disuse atrophy and retraining in individuals of different ages are currently unclear. Here, we provide a brief overview of relevant ...
DOI:
10.3390/genes13081378

10. Skeletal muscle radiodensity and cancer outcomes: A scoping review of the literature

Author:
Taiara Scopel Poltronieri; Nathália Silva de Paula; Gabriela Villaça Chaves
Source:
Nutrition in clinical practice 2022 v.37 no.5 pp. 1117-1141
ISSN:
0884-5336
Subject:
skeletal muscle,   etc   ; computed tomography; elderly; experimental design; nutrition;     Show all 5 Subjects
Abstract:
... Patients with cancer are more prone to experience myosteatosis than healthy individuals. The aim of this review was to summarize the methodologies applied for low skeletal muscle radiodensity (SMD) assessment in oncology patients, as well as to describe the major findings related to SMD and cancer outcomes. This scoping review included studies that were published until November 2020 in English, Po ...
DOI:
10.1002/ncp.10794

11. Aerobic exercise-mediated changes in the expression of glucocorticoid responsive genes in skeletal muscle differ across the day

Author:
Kirsten R. Dunlap; Grant R. Laskin; David S. Waddell; Adam J. Black; Jennifer L. Steiner; Cynthia Vied; Bradley S. Gordon
Source:
Molecular and cellular endocrinology 2022 v.550 pp. 111652
ISSN:
0303-7207
Subject:
skeletal muscle,   etc   ; exercise; gene expression; glucocorticoid receptors; glucocorticoids; myotubes;     Show all 6 Subjects
Abstract:
... Glucocorticoids are released in response to acute aerobic exercise. The objective was to define changes in the expression of glucocorticoid target genes in skeletal muscle in response to acute aerobic exercise at different times of day. We identified glucocorticoid target genes altered in skeletal muscle by acute exercise by comparing data sets from rodents subjected to acute aerobic exercise in t ...
DOI:
10.1016/j.mce.2022.111652

12. Current Advances in Immunoassays for the Detection of β2-Agonists

Author:
Shuyu Ouyang; Shuting Yu; Yingying Le
Source:
Foods 2022 v.11 no.6 pp. -
ISSN:
2304-8158
Subject:
skeletal muscle,   etc   ; blood serum; body fat; feeds; milk; urine;     Show all 6 Subjects
Abstract:
... β₂-agonists are a group of synthetic phenylethanolamine compounds which are traditionally used for treating bronchospasm. These compounds can also increase skeletal muscle mass and decrease body fat. The illegal use of β₂-agonists in food-producing animals results in residue of β₂-agonists in edible tissues and causes adverse health effects in humans. Thus, the detection of β₂-agonists at trace le ...
DOI:
10.3390/foods11060803

13. Factors associated with the progression of myosteatosis in patients with cirrhosis

Author:
Yoji Ishizu; Masatoshi Ishigami; Takashi Honda; Norihiro Imai; Takanori Ito; Kenta Yamamoto; Shinya Yokoyama; Tetsuya Ishikawa; Mitsuhiro Fujishiro
Source:
Nutrition 2022 v.103-104 pp. 111777
ISSN:
0899-9007
Subject:
skeletal muscle,   etc   ; computed tomography; nutrition; regression analysis; subcutaneous fat;     Show all 5 Subjects
Abstract:
... The presence of myosteatosis is one factor associated with poor prognosis for patients with cirrhosis; however, the factors contributing to worsening myosteatosis are, to our knowledge, unknown. The aim of this study was to clarify the changes in myosteatosis, and the factors involved in these changes. The present study enrolled 178 patients with cirrhosis who underwent computed tomography twice t ...
DOI:
10.1016/j.nut.2022.111777

14. Mechanisms of the modulation of actin-myosin interactions by A1-type myosin light chains

Author:
Barbara Wawro; Hanna Nieznanska; Krzysztof Nieznanski; Joanna Gruszczynska-Biegala; Dariusz Stepkowski; Hanna Strzelecka-Golaszewska
Source:
Biochimica et biophysica acta 2022 v.1866 no.6 pp. 130132
ISSN:
0304-4165
Subject:
skeletal muscle,   etc   ; actin; asparagine; aspartic acid; peptides; polymerization; therapeutics;     Show all 7 Subjects
Abstract:
... The interaction of N-terminal extension of the myosin A1 essential light chain (A1 ELC) with actin is receiving increasing attention as a target in utilizing synthetic A1 ELC N-terminal-derived peptides in cardiac dysfunction therapy. To elucidate the mechanism by which these peptides regulate actin-myosin interaction, here we have investigated their effects on the myosin subfragment 1 (S1)-induce ...
DOI:
10.1016/j.bbagen.2022.130132

15. MicroRNA-24-3p promotes skeletal muscle differentiation and regeneration by regulating HMGA1

Author:
Paromita Dey; Miles A. Soyer; Bijan K. Dey
Source:
Cellular and molecular life sciences 2022 v.79 no.3 pp. 170
ISSN:
1420-682X
Subject:
skeletal muscle,   etc   ; gene expression; microRNA; muscle development; muscles; myoblasts;     Show all 6 Subjects
Abstract:
... Numerous studies have established the critical roles of microRNAs in regulating post-transcriptional gene expression in diverse biological processes. Here, we report on the role and mechanism of miR-24-3p in skeletal muscle differentiation and regeneration. miR-24-3p promotes myoblast differentiation and skeletal muscle regeneration by directly targeting high mobility group AT-hook 1 (HMGA1) and r ...
DOI:
10.1007/s00018-022-04168-7

16. New roles for desmin in the maintenance of muscle homeostasis

Author:
Giulio Agnetti; Harald Herrmann; Shenhav Cohen
Source:
FEBS journal 2022 v.289 no.10 pp. 2755-2770
ISSN:
1742-464X
Subject:
skeletal muscle,   etc   ; desmin; homeostasis; mitochondria; muscles; myofibrils; smooth muscle;     Show all 7 Subjects
Abstract:
... Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF contributes to muscle structural and cellular integrity, force transmission, and mitochondrial homeostasis. Mutations in desmin cause myofibril misalignment, mitochondrial dysfunction, and impaired mechanical integrity ...
DOI:
10.1111/febs.15864

17. Novel integrated workflow allows production and in-depth quality assessment of multifactorial reprogrammed skeletal muscle cells from human stem cells

Author:
Dinis Faustino; Heinrich Brinkmeier; Stella Logotheti; Anika Jonitz-Heincke; Hande Yilmaz; Isil Takan; Kirsten Peters; Rainer Bader; Hermann Lang; Athanasia Pavlopoulou; Brigitte M. Pützer; Alf Spitschak
Source:
Cellular and molecular life sciences 2022 v.79 no.5 pp. 229
ISSN:
1420-682X
Subject:
skeletal muscle,   etc   ; bioinformatics; computer simulation; electrophysiology; humans; muscles; phenotype; transcriptome;     Show all 8 Subjects
Abstract:
... Skeletal muscle tissue engineering aims at generating biological substitutes that restore, maintain or improve normal muscle function; however, the quality of cells produced by current protocols remains insufficient. Here, we developed a multifactor-based protocol that combines adenovector (AdV)-mediated MYOD expression, small molecule inhibitor and growth factor treatment, and electrical pulse st ...
DOI:
10.1007/s00018-022-04264-8

18. Insights into muscle stem cell dynamics during postnatal development

Author:
John F. Bachman; Joe V. Chakkalakal
Source:
FEBS journal 2022 v.289 no.10 pp. 2710-2722
ISSN:
1742-464X
Subject:
skeletal muscle,   etc   ; muscles; postnatal development; puberty; stem cells; young adults;     Show all 6 Subjects
Abstract:
... During development, resident stem cell populations contribute to the growth and maturation of tissue and organs. In skeletal muscle, muscle stem cells, or satellite cells (SCs), are responsible for the maturation of postnatal myofibers. However, the role SCs play in later stages of postnatal growth, and thus, when they enter a mature quiescent state is controversial. Here, we discuss the current l ...
DOI:
10.1111/febs.15856

19. Nutrients against Glucocorticoid-Induced Muscle Atrophy

Author:
Min-Kyeong Lee; Hyeon Hak Jeong; Myeong-Jin Kim; Heeyeon Ryu; Jiwon Baek; Bonggi Lee
Source:
Foods 2022 v.11 no.5 pp. -
ISSN:
2304-8158
Subject:
skeletal muscle,   etc   ; glucocorticoids; mechanical loads; muscles; muscular atrophy; strength training;     Show all 6 Subjects
Abstract:
... Glucocorticoid excess is a critical factor contributing to muscle atrophy. Both endogenous and exogenous glucocorticoids negatively affect the preservation of muscle mass and function. To date, the most effective intervention to prevent muscle atrophy is to apply a mechanical load in the form of resistance exercise. However, glucocorticoid-induced skeletal muscle atrophy easily causes fatigue in d ...
DOI:
10.3390/foods11050687

20. Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension

Author:
Su-Jeong Kim; Anjali Devgan; Brendan Miller; Sam Mool Lee; Hiroshi Kumagai; Kenneth A. Wilson; Gabriella Wassef; Richard Wong; Hemal H. Mehta; Pinchas Cohen; Kelvin Yen
Source:
Biochimica et biophysica acta 2022 v.1866 no.1 pp. 130017
ISSN:
0304-4165
Subject:
skeletal muscle,   etc   ; autophagy; cell viability; humans; longevity; mitochondria; peptides; therapeutics;     Show all 8 Subjects
Abstract:
... Autophagy, a highly conserved homeostatic mechanism, is essential for cell survival. The decline of autophagy function has been implicated in various diseases as well as aging. Although mitochondria play a key role in the autophagy process, whether mitochondrial-derived peptides are involved in this process has not been explored.We developed a high through put screening method to identify potentia ...
DOI:
10.1016/j.bbagen.2021.130017