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1. Hydra and the hair follicle – An unconventional comparative biology approach to exploring the human holobiont

Author:
Marta B. Lousada; Tim Lachnit; Janin Edelkamp; Ralf Paus; Thomas C. G. Bosch
Source:
BioEssays 2022 v.44 no.5 pp. e2100233
ISSN:
0265-9247
Subject:
skin diseases,   etc   ; Hydra; freshwater; hair follicles; hairs; humans; immunity; metabolism; microbiome; microorganisms; skin (animal); therapeutics;     Show all 12 Subjects
Abstract:
... The microbiome of human hair follicles (HFs) has emerged as an important player in different HF and skin pathologies, yet awaits in‐depth exploration. This raises questions regarding the tightly linked interactions between host environment, nutrient dependency of host‐associated microbes, microbial metabolism, microbe‐microbe interactions and host immunity. The use of simple model systems facilita ...
DOI:
10.1002/bies.202100233

2. Genetics of inherited skin disorders in dogs

Author:
Tosso Leeb; Petra Roosje; Monika Welle
Source:
veterinary journal 2022 v.279 pp. 105782
ISSN:
1090-0233
Subject:
skin diseases,   etc   ; dogs; pathophysiology; prognosis; therapeutics;     Show all 5 Subjects
Abstract:
... Canine genodermatoses represent a broad spectrum of diseases with diverse phenotypes. Modern genetic technology including whole genome sequencing has expedited the identification of novel genes and greatly simplified the establishment of genetic diagnoses in such heterogeneous disorders. The precise genetic diagnosis of a heritable skin disorder is essential for the appropriate counselling of owne ...
DOI:
10.1016/j.tvjl.2021.105782

3. Beneficial effect of oclacitinib in a case of feline pemphigus foliaceus

Author:
Isaac Carrasco; Marta Martínez; Gloria Albinyana
Source:
Veterinary dermatology 2021 v.32 no.3 pp. 299-301
ISSN:
0959-4493
Subject:
skin diseases,   etc   ; cats; glucocorticoids; therapeutics; veterinary medicine;     Show all 5 Subjects
Abstract:
... Pemphigus foliaceous (PF) is a pustular, immune‐mediated skin disease characterised by acantholytic cells and commonly treated with high doses of glucocorticoids. This report describes one case of feline PF successfully controlled using oral oclacitinib, suggesting a possible therapeutic alternative to glucocorticoids in some cases. ...
DOI:
10.1111/vde.12949

4. Rapid spread of a virulent amphibian pathogen in nature

Author:
Barbora Thumsová; Emilio González-Miras; Sally C. Faulkner; Jaime Bosch
Source:
Biological invasions 2021 v.23 no.10 pp. 3151-3160
ISSN:
1387-3547
Subject:
skin diseases,   etc   ; pathogens; threatened species; toads; virulence;     Show all 5 Subjects
Abstract:
... Considering that emerging infectious diseases are one of the major drivers of global amphibian decline, controlling the spread of infections are even more challenging. Amphibian skin disease chytridiomycosis, which is caused by two species of fungi belonging to the Batrachochytrium genus, has been detected in at least 700 amphibian species causing mass mortalities in all continents where amphibian ...
DOI:
10.1007/s10530-021-02571-y

5. Traumatic Blepharitis Including Cutanous Changes with a Clinical Appearance of Immune-Mediated Disease

Author:
Kecova Helga; Milcic-Matic Natalija; Lazic Tatjana; Grozdanic Sinisa
Source:
Acta veterinaria 2021 v.71 no.1 pp. 120-130
ISSN:
1820-7448
Subject:
skin diseases,   etc   ; Labrador Retriever; Panicum virgatum; antibiotics; dogs; males; patients; therapeutics;     Show all 8 Subjects
Abstract:
... A four-year-old intact male Labrador retriever was presented with acute onset of ulcerative lesions around both eyes, on the mucocutaneous junctions around the muzzle and nares, and on the lateral aspects of paw pads. All lesions were symmetrical and well demarcated. The rest of ocular and systemic examination was unremarkable. The onset of lesions was acute and coincided with an episode of intens ...
DOI:
10.2478/acve-2021-0010

6. A case report of the beneficial effect of oclacitinib in a dog with pemphigus vulgaris

Author:
Nicola Martinez; Beth McDonald; Ann Crowley
Source:
Veterinary dermatology 2022 v.33 no.3 pp. 237
ISSN:
0959-4493
Subject:
skin diseases,   etc   ; betamethasone; case studies; cyclosporine; dogs; glucocorticoids; immunosuppression; veterinary medicine;     Show all 8 Subjects
Abstract:
... Pemphigus vulgaris is a rare immune‐mediated skin disorder of the dog, usually treated with immunosuppressive medications such as oral glucocorticoids, azathioprine or ciclosporin. Herein we report the successful treatment of pemphigus vulgaris in a dog, using oclacitinib and a topical product containing fucidic acid (0.5 % w/w) and betamethasone valerate. ...
DOI:
10.1111/vde.13063

7. Caregiver burden, treatment complexity, and the veterinarian–client relationship in owners of dog with skin disease

Author:
Mary Beth Spitznagel; Karlee Patrick; Andrew Hillier; Margaret Gober; Mark D. Carlson
Source:
Veterinary dermatology 2022 v.33 no.3 pp. 208-213
ISSN:
0959-4493
Subject:
skin diseases,   etc   ; caregivers; disease course; disease severity; dogs; models; variance; veterinary medicine;     Show all 8 Subjects
Abstract:
... BACKGROUND: Increasing complexity of treatment plans is associated with higher levels of caregiver burden in owners of dogs with skin disease. It is possible that elevated caregiver burden resulting from treatment complexity could, in turn, affect the veterinarian–client relationship. HYPOTHESES/OBJECTIVES: We expected that treatment complexity, caregiver burden, and the client’s perception of the ...
DOI:
10.1111/vde.13065

8. Demodex folliculorum and Demodex brevis (Acari: Demodecidae) and their association with facial and non-facial pathologies

Author:
Amanda Nery Pormann; Lucas Vieira; Fernanda Majolo; Liana Johann; Guilherme Liberato da Silva
Source:
International journal of acarology 2021 v.47 no.5 pp. 396-403
ISSN:
1945-3892
Subject:
skin diseases,   etc   ; Demodex brevis; Demodex folliculorum; acarology; demodicosis; fauna; immune response; inflammation; mites; patients;     Show all 10 Subjects
Abstract:
... The mites Demodex folliculorum (Simon) and Demodex brevis Akbulatova are part of the regular human skin fauna, found in the pilosebaceous unit, and their infestations might cause the disease known as demodicosis. Inflammatory response is triggered by this interaction in patients, causing the appearance of several facial dermatoses. In the present revision, mites will be characterized and their ass ...
DOI:
10.1080/01647954.2021.1919757

9. Increased Expression of Toll-Like Receptor 4 in Skin of Dogs with Discoid Lupus Erythematous (DLE)

Author:
Alessandro Di Cerbo; Sara Giusti; Francesca Mariotti; Andrea Spaterna; Giacomo Rossi; Gian Enrico Magi
Source:
Animals 2021 v.11 no.4 pp. -
ISSN:
2076-2615
Subject:
skin diseases,   etc   ; Toll-like receptor 4; chemokines; heat stress; keratinocytes; lipopolysaccharides; macrophages; pathogenesis; therapeutics;     Show all 9 Subjects
Abstract:
... Discoid lupus erythematous (DLE) is a common autoimmune skin disorder of dogs where keratinocytes play a pivotal role both in the innate and adaptive immune responses. As for the innate response, pattern recognition receptors (PRR), including Toll-like receptors (TLRs), can activate macrophages and immune tissue cells allowing for transmission and transduction of signals through cytokine and chemo ...
DOI:
10.3390/ani11041044

10. Skin defenses of North American salamanders against a deadly salamander fungus

Author:
K. E. Pereira; S. K. Woodley
Source:
Animal conservation 2021 v.24 no.4 pp. 552-567
ISSN:
1367-9430
Subject:
skin diseases,   etc   ; Ambystoma; Cryptobranchus alleganiensis; Desmognathus; Plethodon; biodiversity; fungi; pathogens; peptides; salamanders and newts;     Show all 10 Subjects
Abstract:
... The recently emerged fungal pathogen, Batrachochytrium salamandrivorans (Bsal) causes the lethal skin disease chytridiomycosis in susceptible salamander species and is predicted to emerge within the Americas with devastating consequences. Host responses to Bsal are variable but the factors underlying these differences are unknown. To investigate the role of skin‐associated immune defenses against ...
DOI:
10.1111/acv.12666

11. Fatal chytridiomycosis in the Moroccan midwife toad Alytes maurus and potential distribution of Batrachochytrium dendrobatidis across Morocco

Author:
Barbora Thumsová; David Donaire-Barroso; El Hassan El Mouden; Jaime Bosch
Source:
African journal of herpetology 2022 v.71 no.1 pp. 72-82
ISSN:
2153-3660
Subject:
skin diseases,   etc   ; Alytes; Batrachochytrium dendrobatidis; Palearctic region; extinction; fungi; herpetology; models; toads; Mediterranean region; Morocco;     Show all 11 Subjects
Abstract:
... Multiple threats, including emerging infectious diseases, are contributing to the extinction of amphibians worldwide. One of the most devastating diseases is the fatal amphibian skin disease chytridiomycosis caused by the fungus Batrachochytrium dendrobatidis (Bd). The presence of Bd in North Africa was described in 2011 and this included the distribution range of the endemic Moroccan midwife toad ...
DOI:
10.1080/21564574.2021.1998235

12. Detection and identification of dermatophytes based on currently available methods – a comparative study

Author:
S. Gnat; D. Łagowski; A. Nowakiewicz; M. Dyląg; M. Osińska; M. Sawicki
Source:
Journal of applied microbiology 2021 v.130 no.1 pp. 278-291
ISSN:
1364-5072
Subject:
skin diseases,   etc   ; comparative study; diagnostic techniques; epidemiological studies; fluorescence microscopy; humans; keratinophilic fungi; quantitative polymerase chain reaction;     Show all 8 Subjects
Abstract:
... AIMS: Accurate identification of dermatophytes is essential for implementing appropriate antifungal treatment and epidemiological analysis. However, the limitations of conventional diagnostics are a frequently discussed topic, and new diagnostic techniques are constantly expanding. In this study, we assess the suitability of conventional diagnostic techniques in comparison to the real‐time PCR ass ...
DOI:
10.1111/jam.14778

13. The regulatory effects of PTPN6 on inflammatory process: Reports from mice to men

Author:
Salin Kiratikanon; Siriporn C. Chattipakorn; Nipon Chattipakorn; Sirinart Kumfu
Source:
Archives of biochemistry and biophysics 2022 v.721 pp. 109189
ISSN:
0003-9861
Subject:
skin diseases,   etc   ; apoptosis; biophysics; cytokines; humans; inflammation; models; necroptosis; protein-tyrosine-phosphatase; regulatory proteins; signal transduction; therapeutics;     Show all 12 Subjects
Abstract:
... Protein tyrosine phosphatase non-receptor type 6 (PTPN6) is a key regulatory protein in cellular signal transduction in the control of inflammation and cell death. Impairment of PTPN6 is known to be associated with human inflammatory diseases including neutrophilic dermatosis; however, comprehensive studies of PTPN6-associated neutrophilic dermatosis have not clearly identified the relationships i ...
DOI:
10.1016/j.abb.2022.109189

14. Metallocatanionic vesicle-mediated enhanced singlet oxygen generation and photodynamic therapy of cancer cells

Author:
Bunty Sharma; Akhil Jain; Lluïsa Pérez-García; Julie A. Watts; Frankie J. Rawson; Ganga Ram Chaudhary; Gurpreet Kaur
Source:
Journal of materials chemistry B 2022 v.10 no.13 pp. 2160-2170
ISSN:
2050-7518
Subject:
skin diseases,   etc   ; biochemical pathways; lighting; magnetism; methylene blue; oleic acid; photobleaching; photochemotherapy; phototoxicity; singlet oxygen; sodium; water solubility;     Show all 12 Subjects
Abstract:
... In clinics, photodynamic therapy (PDT) is established as a non-invasive therapeutic modality for certain types of cancers and skin disease. However, due to poor water solubility, photobleaching, and the dark toxicity of photosensitizers (PSs), further developments are required to improve the efficiency of PDT. Herein, we report the role of metallocatanionic vesicles (MCVs) in enhancing the phototo ...
DOI:
10.1039/d2tb00011c

15. Co-delivery of triamcinolone acetonide and verapamil for synergistic treatment of hypertrophic scars via carboxymethyl chitosan and Bletilla striata polysaccharide-based microneedles

Author:
Nan Zhang; Lingping Xue; Ayesha Younas; Fenfen Liu; Junhong Sun; Zhuolin Dong; Yongxing Zhao
Source:
Carbohydrate polymers 2022 v.284 pp. 119219
ISSN:
0144-8617
Subject:
skin diseases,   etc   ; Bletilla striata; chitosan; collagen; cytotoxicity; dermis; ethyl cellulose; hydroxyproline; hyperplasia; pain; strength (mechanics); therapeutics; triamcinolone; verapamil;     Show all 14 Subjects
Abstract:
... Hypertrophic scar (HS) is a frequently diagnosed skin disease that is difficult to treat. HS is usually associated with itching and pain and causes both physical and psychological issues. In this study, a safe, convenient, and efficient therapy for HS is developed. Carboxymethyl chitosan (CMCH) and Bletilla striata polysaccharide (BSP) are used to prepare microneedles (MN) via a micro-molding meth ...
DOI:
10.1016/j.carbpol.2022.119219

16. Illuminating the Role of Vitamin A in Skin Innate Immunity and the Skin Microbiome: A Narrative Review

Author:
Fritzlaine C. Roche; Tamia A. Harris-Tryon
Source:
Nutrients 2021 v.13 no.2 pp. -
ISSN:
2072-6643
Subject:
skin diseases,   etc   ; immune response; innate immunity; microbiome; vitamin A;     Show all 5 Subjects
Abstract:
... Vitamin A is a fat-soluble vitamin that plays an important role in skin immunity. Deficiencies in Vitamin A have been linked to impaired immune response and increased susceptibility to skin infections and inflammatory skin disease. This narrative review summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that p ...
DOI:
10.3390/nu13020302

17. Prevalence of commonly diagnosed disorders in UK dogs under primary veterinary care: results and applications

Author:
Dan G. O’Neill; Hannah James; Dave C. Brodbelt; David B. Church; Camilla Pegram
Source:
BMC veterinary research 2021 v.17 no.1 pp. 69
ISSN:
1746-6148
Subject:
skin diseases,   etc   ; castration; obesity; otitis externa; periodontal diseases; pets;     Show all 6 Subjects
Abstract:
... BACKGROUND: Although dogs are a commonly owned companion animal in the UK, the species experiences many health problems that are predictable from demographic information. This study aimed to use anonymised veterinary clinical data from the VetCompass™ Programme to report the frequency of common disorders of dogs under primary veterinary care in the UK during 2016 and to explore effects associated ...
DOI:
10.1186/s12917-021-02775-3

18. Novel genetic alteration in congenital melanocytic nevus: MAP2K1 germline mutation with BRAF somatic mutation

Author:
Yun Zou; Yi Sun; Xiaojing Zeng; Yun Liu; Qingqing Cen; Hao Gu; Xiaoxi Lin; Ren Cai; Hui Chen
Source:
Hereditas 2020 v.157 no.1 pp. 35
ISSN:
1601-5223
Subject:
skin diseases,   etc   ; dermis; germ cells; melanoma; pathogenesis; patients; somatic mutation;     Show all 7 Subjects
Abstract:
... Congenital melanocytic nevus (CMN) represent a benign proliferative skin disease in the epidermis and dermis. CMN are historically known to be associated with activating NRAS or BRAF mutations. Melanoma frequently harbors the BRAF p.Val600Glu mutation, which is also commonly found in benign nevi. A recent study reported mutation of MAP2K1, a downstream effector of the RAS-RAF-MEK pathway, in melan ...
DOI:
10.1186/s41065-020-00147-9

19. Prediction of Skin Disease Using Ensemble Data Mining Techniques and Feature Selection Method—a Comparative Study

Author:
Anurag Kumar Verma; Saurabh Pal; Surjeet Kumar
Source:
Applied biochemistry and biotechnology 2020 v.190 no.2 pp. 341-359
ISSN:
0273-2289
Subject:
skin diseases,   etc   ; algorithms; artificial intelligence; comparative study; data collection; prediction;     Show all 6 Subjects
Abstract:
... Nowadays, skin disease is a major problem among peoples worldwide. Different machine learning techniques are applied to predict the various classes of skin disease. In this research paper, we have applied six different machine learning algorithm to categorize different classes of skin disease using three ensemble techniques and then a feature selection method to compare the results obtained from d ...
DOI:
10.1007/s12010-019-03093-z

20. Engineering of diseased human skin equivalent using 3D cell printing for representing pathophysiological hallmarks of type 2 diabetes in vitro

Author:
Byoung Soo Kim; Minjun Ahn; Won-Woo Cho; Ge Gao; Jinah Jang; Dong-Woo Cho
Source:
Biomaterials 2021 v.272 pp. 120776
ISSN:
0142-9612
Subject:
skin diseases,   etc   ; adipocytes; artificial skin; biocompatible materials; disease models; drug development; hyperglycemia; hypertrophy; insulin resistance; keratinocytes; noninsulin-dependent diabetes mellitus;     Show all 11 Subjects
Abstract:
... Despite many significant advances in 3D cell printing for skin, a disease model displaying the pathological processes present in the native skin has not been reported yet. Therefore, we were motivated for modeling a 3D diseased skin tissue with pathophysiological hallmarks of type 2 diabetes in vitro based on 3D cell printing technique. By stimulating epidermal-dermal intercellular crosstalk found ...
DOI:
10.1016/j.biomaterials.2021.120776