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1. Prune Belly Syndrome in the Pig (Sus scrofa domesticus)

Author:
Martín-Alguacil, N.; Avedillo, L.
Source:
Journal of comparative pathology 2020 v.174 pp. 81-85
ISSN:
0021-9975
Subject:
spleen,   etc   ; cryptorchidism; females; liver; males; piglets; testes; urinary tract;     Show all 8 Subjects
Abstract:
... Prune belly syndrome (PBS) is a rare multisystemic disease characterized by a deficiency of abdominal wall musculature, urinary tract anomalies and bilateral intra-abdominal testes. PBS in females is called pseudo prune belly syndrome (PPBS) and is characterized by abdominal wall laxity and urinary tract defects. We report three male and one female stillborn piglets with abdominal distension, hypo ...
DOI:
10.1016/j.jcpa.2019.11.004

2. Development of an immunocompetent murine model of pulmonary infection due to Scedosporium apiospermum

Author:
Luna-Rodríguez, Carolina E.; Treviño-Rangel, Rogelio de J.; Soto-Domínguez, Adolfo; Becerril-García, Miguel A.; González-Montalvo, Martin A.; Saldivar M, Andrea M.; Rodríguez-Rocha, Humberto; Gonzalez, Gloria M.
Source:
Microbial pathogenesis 2020 v.142 pp. 104073
ISSN:
0882-4010
Subject:
spleen,   etc   ; Scedosporium; animal models; brain; conidia; disease progression; fungi; histopathology; hyphae; kidneys; liver; lungs; mice; neutrophils;     Show all 14 Subjects
Abstract:
... A pulmonary infection model due to Scedosporium apiospermum in immunocompetent mice was developed. BALB/c mice were infected by endotracheal intubation with 5 × 10⁶ conidia/mouse and disease progression was evaluated on days 1, 3, 5, 7, 11, 16, 21, 30, 50 and 60 post-infection through quantitative culture and histopathological analysis of lungs, livers, spleens, brains, and kidneys. There was no e ...
DOI:
10.1016/j.micpath.2020.104073

3. The Human Spleen in Malaria: Filter or Shelter?

Author:
Henry, Benoît; Roussel, Camille; Carucci, Mario; Brousse, Valentine; Ndour, Papa Alioune; Buffet, Pierre
Source:
Trends in parasitology 2020 v.36 no.5 pp. 435-446
ISSN:
1471-4922
Subject:
spleen,   etc   ; adaptive immunity; anemia; biomass; drugs; erythrocytes; gametocytes; hemolysis; humans; malaria; parasites; pathogenesis; splenomegaly;     Show all 13 Subjects
Abstract:
... The human spleen is an immune sentinel and controls red blood cell (RBC) quality. By mechanically retaining subsets of infected RBCs, the spleen may reduce the pace at which the parasite biomass increases before the adaptive immune response operates. Conversely, the spleen may contribute to malaria pathogenesis, particularly anemia that is associated with splenomegaly. Large spleens may also shelt ...
DOI:
10.1016/j.pt.2020.03.001

4. Investigation into the Pathology of Idiopathic Systemic Amyloidosis in Four Captive Badgers (Meles meles)

Author:
Bianco, C.; Sánchez-Cordón, P.J.; Verin, R.; Godinho, A.; Weyer, U.; Lesellier, S.; Spiropoulos, J.; Floyd, T.; Everest, D.; Núñez, A.
Source:
Journal of comparative pathology 2020 v.176 pp. 128-132
ISSN:
0021-9975
Subject:
spleen,   etc   ; Meles meles; Mycobacterium bovis; amyloid; amyloidosis; badgers; histopathology; immunohistochemistry; kidney diseases; splenomegaly; tissues; vaccines;     Show all 12 Subjects
Abstract:
... Systemic idiopathic amyloidosis was described in four captive badgers (Meles meles). Two animals (B1 and B2) were not enrolled in any trial, while animals B3 and B4 took part in a vaccine efficacy study and had been challenged with Mycobacterium bovis. A full set of tissues was collected and processed routinely for histopathological, immunohistochemical and ultrastructural studies. Splenomegaly wa ...
DOI:
10.1016/j.jcpa.2020.02.012

5. Chinese medicine Xiaoshui decoction inhibits malignant pleural effusion in mice and mediates tumor-associated macrophage polarization by activating autophagy

Author:
Jin, Zhichao; Shen, Chunfeng; Zhang, Haidong; Qi, Runzhi; Guo, Qiujun; Liu, Rui; Hua, Baojin; Shi, Zhan
Source:
Journal of ethnopharmacology 2020 v.249 pp. 112412
ISSN:
0378-8741
Subject:
spleen,   etc   ; Oriental traditional medicine; angiogenesis; autophagy; cisplatin; macrophages; mice; models; permeability; phenotype;     Show all 10 Subjects
Abstract:
... Xiaoshui decoction (XSD) is a traditional Chinese medicine compound prescription that has been shown to reinforce the spleen and remove the fluid retention, while being widely used in the treatment of malignant pleural effusion (MPE). We previously reported that XSD alleviates symptoms and improves the quality of life in patients with MPE; however, the mechanism employed by XSD on MPE has not yet ...
DOI:
10.1016/j.jep.2019.112412

6. Extracellular matrix composition of different spleen compartments of fruit bats

Author:
Hanadhita, Desrayni; Rahma, Anisa; Wahid, Muhammad R.; Mayasari, Ni Luh Putu I.; Satyaningtijas, Aryani S.; Hondo, Eiichi; Agungpriyono, Srihadi
Source:
Anatomia, histologia, embryologia 2020 v.49 no.2 pp. 281-289
ISSN:
0340-2096
Subject:
spleen,   etc   ; Cynopterus; Rousettus; basement membrane; collagen; elastin; extracellular matrix; immunohistochemistry; laminin; mammals; phylogeny;     Show all 11 Subjects
Abstract:
... The distribution and composition of extracellular matrix (ECM) of the spleen in two species of fruit bats, namely Cynopterus titthaecheilus and Rousettus leschenaultii, were examined by histochemistry and immunohistochemistry. Reticular fibres accompanied by laminin were identified to make up the splenic stromal network. Types I and III collagen were identified in various spleen compartments with ...
DOI:
10.1111/ahe.12526

7. Clinical relevance of splenic nodules or heterogeneous splenic parenchyma assessed by cytologic evaluation of fine‐needle samples in 125 dogs (2011‐2015)

Author:
Yankin, Igor; Nemanic, Sarah; Funes, Silvia; de Morais, Helio; Gorman, Elena; Ruaux, Craig
Source:
Journal of veterinary internal medicine 2020 v.34 no.1 pp. 125-131
ISSN:
0891-6640
Subject:
spleen,   etc   ; adults; cell biology; decision making; dogs; inflammation; medical records; statistical analysis; ultrasonics; ultrasonography;     Show all 10 Subjects
Abstract:
... BACKGROUND: Splenic nodules and heterogeneous parenchyma are seen frequently in abdominal ultrasound examinations of dogs, but the clinical importance of these lesions remains unclear. OBJECTIVES: To determine whether specific ultrasonographic findings correlate with clinically relevant cytologic diagnoses and determine what sonographic features are correlated with these diagnoses. Another objecti ...
DOI:
10.1111/jvim.15648
PubMed:
31692075
PubMed Central:
PMC6979272

8. Muscle melanisation of southern sand flathead (Platycephalus bassensis) in the Tamar Estuary, Tasmania, Australia

Author:
Stocker, Clayton W.; Haddy, James; Lyle, Jeremy; Nowak, Barbara F.
Source:
Environmental pollution 2020 v.256 pp. 113452
ISSN:
0269-7491
Subject:
spleen,   etc   ; Platycephalus bassensis; estuaries; eumelanin; fillets; fish; histology; image analysis; liver; melanization; muscles; surface area; Tasmania;     Show all 13 Subjects
Abstract:
... Tasmanian recreational fishers have reported the presence of dark pigmentations in the usually white fillets of southern sand flathead (Platycephalus bassensis), a phenomenon known as muscle melanisation. Based on histology, it is suggested that eumelanin and pheomelanin are involved in the occurrence of the phenomenon. A gross melanisation scoring system was validated through a comparison with an ...
DOI:
10.1016/j.envpol.2019.113452

9. Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies

Author:
Rémy, Sylvie; Le Pape, Gilles; Gourichon, David; Gardin, Yannick; Denesvre, Caroline
Source:
Veterinary research 2020 v.51 no.1 pp. 24
ISSN:
1297-9716
Subject:
spleen,   etc   ; DNA; Marek disease; Meleagrid alphaherpesvirus 1; antibodies; chickens; controllers; excretion; feathers; lymphoma; models; vaccines; viral load; viruses;     Show all 14 Subjects
Abstract:
... Marek’s disease (MD) is a major disease of chickens induced by Marek’s disease virus (MDV) associated to lethal lymphomas. Current MD vaccines protect against lymphomas, but fail to prevent infection and shedding. The control of MDV shedding is crucial in order to eradicate this highly contagious virus. Like pathogenic MDV, MD vaccines infect the feather follicles of the skin before being shed int ...
DOI:
10.1186/s13567-020-00749-1
PubMed:
32093754
PubMed Central:
PMC7041111

10. Radioprotective effects and mechanisms of animal, plant and microbial polysaccharides

Author:
Wang, Wenjie; Xue, Changhu; Mao, Xiangzhao
Source:
International journal of biological macromolecules 2020 v.153 pp. 373-384
ISSN:
0141-8130
Subject:
spleen,   etc   ; DNA damage; adverse effects; brain; human health; in vitro studies; ionizing radiation; liver; polysaccharides; radioprotective agents; radioprotective effect; toxicity;     Show all 12 Subjects
Abstract:
... Ionizing radiation is increasingly used to successfully diagnose many human health problems, but ionizing radiation may cause damage to organs/tissues in the living organisms such as the spleen, liver, skin, and brain. Many radiation protective agents have been discovered, with the deepening of radiation research. Unfortunately, these protective agents have many side effects, which cause drug resi ...
DOI:
10.1016/j.ijbiomac.2020.02.203

11. MiR-155-5p plays as a “janus” in the expression of inflammatory cytokines induced by T-2 toxin

Author:
Guo, Pu; Qiao, Fang; Huang, Deyu; Wu, Qinghua; Chen, Tianlun; Badawy, Sara; Cheng, Guyue; Hao, Haihong; Xie, Shuyu; Wang, Xu
Source:
Food and chemical toxicology 2020 v.140 pp. 111258
ISSN:
0278-6915
Subject:
spleen,   etc   ; T-2 toxin; bioinformatics; cytokines; gene expression; immune response; in vivo studies; inflammation; luciferase; mice; prediction; toxicity;     Show all 12 Subjects
Abstract:
... Although many studies have shown that inflammatory response plays a crucial role in the various toxic effects of T-2 toxin, there are relatively few reports on the mechanism of this phenomenon. Meanwhile, accumulating evidence has shown that miR-155-5p is activated in the inflammatory response. As molecular pathways and mechanisms involved in T-2 toxin-induced inflammatory response are poorly eluc ...
DOI:
10.1016/j.fct.2020.111258

12. Deficiency of O-linked-glycosylation regulates activation of T cells and aggravates Concanavalin A-induced liver injury

Author:
Hao, Xiaohua; Gao, Meixin; He, Lingling; Ye, Xiaohui; Yang, Junru; Zhang, Fuyang; Liu, Ran; Wei, Hongshan
Source:
Toxicology 2020 v.433-434 pp. 152411
ISSN:
0300-483X
Subject:
spleen,   etc   ; T-lymphocytes; apoptosis; autoimmune hepatitis; blood serum; concanavalin A; cytokines; flow cytometry; glycosylation; intravenous injection; liver; necrosis; thymus gland;     Show all 13 Subjects
Abstract:
... Protein glycosylation is involved in immunological recognition and immune cell activation. The role of O-glycosylation in Concanavalin A (Con A)-induced autoimmune hepatitis (AIH) was elucidated in the present study.Mice were intravenously injected with Con A (10 mg/kg) to establish an AIH mouse model. Here, 24 h prior to administration of Con A, experimental mice were intragastrically administrat ...
DOI:
10.1016/j.tox.2020.152411

13. Immunohistological Biomarkers of Toxicity by a Pharmaceutical Antidepressant in the Freshwater Cichlid Fish Cichlasoma dimerus (Teleostei, Cichliformes)

Author:
Rey Vázquez, Graciela; Da Cuña, Rodrigo Hernán; Dorelle, Luciana Soledad; Lo Nostro, Fabiana Laura
Source:
Bulletin of environmental contamination and toxicology 2020 v.104 no.2 pp. 180-184
ISSN:
0007-4861
Subject:
spleen,   etc   ; Cichlasoma dimerus; Cichliformes; antidepressants; biomarkers; fish; freshwater; histology; homeostasis; immune response; iron; kidneys; macrophages; recycling; toxicity; water quality;     Show all 16 Subjects
Abstract:
... Melano-macrophage centers (MMCs) are nodular clusters of pigmented macrophages, implicated in homeostasis and destruction and recycling of endogenous and exogenous material. They can increase in size and/or frequency under environmental stress resulting in immunohistological biomarkers of water quality. Fluoxetine (FLX), a commonly prescribed antidepressant, can cause neuroendocrine, behavioral an ...
DOI:
10.1007/s00128-019-02770-3

14. Optimal immobilization of trypsin from the spleen of albacore tuna (Thunnus alalunga) and its characterization

Author:
Poonsin, Tanchanok; Simpson, Benjamin K.; Visessanguan, Wonnop; Yoshida, Asami; Klomklao, Sappasith
Source:
International journal of biological macromolecules 2020 v.143 pp. 462-471
ISSN:
0141-8130
Subject:
spleen,   etc   ; Thunnus alalunga; agarose; glass; glutaraldehyde; heat inactivation; hydrolysis; immobilized enzymes; pH; silica; solvents; soybeans; temperature; trypsin; trypsin inhibitors; tuna;     Show all 16 Subjects
Abstract:
... Trypsin purified from the spleen of albacore tuna was immobilized onto Octyl Sepharose CL-4B, glutaraldehyde activated silica and 5′-4,4′-dimethyltryptamine-thymidine-succinyl controlled pore glass. Trypsin was highly and efficiently immobilized onto Octyl Sepharose CL-4B, with the highest activity (6.26 U/g support) and specific activity (1.45 U/mg bound protein). The optimum conditions for tryps ...
DOI:
10.1016/j.ijbiomac.2019.10.030

15. In vitro inhalation bioaccessibility procedures for lead in PM2.5 size fraction of soil assessed and optimized by in vivo-in vitro correlation

Author:
Zhong, Laijin; Liu, Xiaolan; Hu, Xin; Chen, Yijun; Wang, Hongwei; Lian, Hong-zhen
Source:
Journal of hazardous materials 2020 v.381 pp. 121202
ISSN:
0304-3894
Subject:
spleen,   etc   ; bioavailability; blood; breathing; epithelium; heavy metals; kidneys; lead; liver; lungs; mice; mining; models; particulates; risk assessment; soil;     Show all 16 Subjects
Abstract:
... In order to assess and optimize frequently used in vitro inhalation bioaccessibility procedures for heavy metals in the inhalation risk assessment, in vivo inhalation bioavailability of Pb in simulated atmosphere fine particles (PM2.5) from aging soils spiked with lead compounds and field soils in lead-zinc mining areas was investigated via intranasally instilled experiments with these PM2.5 suspe ...
DOI:
10.1016/j.jhazmat.2019.121202

16. Fe³⁺-Coordinated Multifunctional Elastic Nanoplatform for Effective in Vivo Gene Transfection

Author:
Zhang, Min; Elango, Jeevithan; Guo, Xinli; Fan, Hua; Cui, Mingxiao; Wang, Mingfu; Liu, Kehai
Source:
ACS applied materials & interfaces 2020 v.12 no.3 pp. 3453-3464
ISSN:
1944-8252
Subject:
spleen,   etc   ; adverse effects; crosslinking; deformation; filters; genes; hydrogen peroxide; hypoxia; iron; neoplasms; oxygen; peptides; polyethyleneimine; reticuloendothelial system; transfection;     Show all 15 Subjects
Abstract:
... The common phenomenon that the nonviral vectors have much lower transfection efficiency in vivo than in vitro greatly restricts their further developments and applications. Possible reasons are lacking targeting ability, elimination by the reticuloendothelial system (RES), and insufficient nuclear transport. Here, a novel, flexible, and deformable polymer Fe@PEI-R12 (tLyp-1-NLS) is reported for sh ...
DOI:
10.1021/acsami.9b19585

17. Histological effects on the kidney, spleen, and liver of Nile tilapia Oreochromis niloticus fed different concentrations of probiotic Lactobacillus plantarum

Author:
Ruiz, Maria Luiza; Owatari, Marco Shizuo; Yamashita, Marcela Maya; Ferrarezi, José Victor Saffadi; Garcia, Patricia; Cardoso, Lucas; Martins, Maurício Laterça; Mouriño, José Luiz Pedreira
Source:
Tropical animal health and production 2020 v.52 no.1 pp. 167-176
ISSN:
0049-4747
Subject:
spleen,   etc   ; Lactobacillus plantarum; Oreochromis niloticus; diet; fish; goblet cells; hematologic tests; histology; juveniles; kidneys; leukocytes; liver; probiotics; tanks;     Show all 14 Subjects
Abstract:
... The aims of this study were to evaluate the inclusion of different concentrations of Lactobacillus plantarum in Nile tilapia diet and to verify histological effects on tissues of the animal organs, as well as to verify its effects on growth parameters and possible increase in the immune system. A total of 240 juveniles were distributed in 16 tanks arranged in a recirculation system. One control gr ...
DOI:
10.1007/s11250-019-02001-1

18. B cells induced by Schistosoma japonicum infection display diverse regulatory phenotypes and modulate CD4+ T cell response

Author:
Xiao, Junli; Guan, Fei; Sun, Li; Zhang, Yijie; Zhang, Xiaoyan; Lu, Shengjun; Liu, Wenqi
Source:
Parasites & vectors 2020 v.13 no.1 pp. 147
ISSN:
1756-3305
Subject:
spleen,   etc   ; B-lymphocytes; CD4-positive T-lymphocytes; Schistosoma japonicum; antibodies; antigens; cercariae; coculture; eggs; immune response; immunosuppression; interleukin-10; mice; phenotype; schistosomiasis; transcription factors; transforming growth factor beta;     Show all 17 Subjects
Abstract:
... BACKGROUND: The increased activity of regulatory B cells (Breg) is known to be involved in immunosuppression during helminth infection, which is characterized by inducing IL-10-producing Breg cells. However, the current knowledge of B cell subsets differentiation and IL-10-independent immunoregulatory mechanisms of B cells in schistosomiasis is insufficient. METHODS: BALB/c mice were percutaneousl ...
DOI:
10.1186/s13071-020-04015-3
PubMed:
32197642
PubMed Central:
PMC7082913

19. Rickettsiae in the common pipistrelle Pipistrellus pipistrellus (Chiroptera: Vespertilionidae) and the bat soft tick Argas vespertilionis (Ixodida: Argasidae)

Author:
Zhao, Shuo; Yang, Meihua; Liu, Gang; Hornok, Sándor; Zhao, Shanshan; Sang, Chunli; Tan, Wenbo; Wang, Yuanzhi
Source:
Parasites & vectors 2020 v.13 no.1 pp. 10
ISSN:
1756-3305
Subject:
spleen,   etc   ; Carios vespertilionis; DNA; Pipistrellus pipistrellus; Rickettsia parkeri; Rickettsia rickettsii; Rickettsia slovaca; bacteria; genetic markers; heart; kidneys; large intestine; liver; lungs; phylogeny; small intestine; ticks; tissues; China;     Show all 19 Subjects
Abstract:
... BACKGROUND: Increasing molecular evidence supports that bats and/or their ectoparasites may harbor vector-borne bacteria, such as bartonellae and borreliae. However, the simultaneous occurrence of rickettsiae in bats and bat ticks has been poorly studied. METHODS: In this study, 54 bat carcasses and their infesting soft ticks (n = 67) were collected in Shihezi City, northwestern China. The heart, ...
DOI:
10.1186/s13071-020-3885-x
PubMed:
31918751
PubMed Central:
PMC6953312

20. In vivo acute and subacute toxicities of phenolic extract from rambutan (Nephelium lappaceum) peels by oral administration

Author:
Li, Yujing; Zhuang, Yongliang; Tian, Wenhui; Sun, Liping
Source:
Food chemistry 2020 v.320 pp. 126618
ISSN:
0308-8146
Subject:
spleen,   etc   ; Nephelium lappaceum; acute toxicity; adverse effects; histopathology; kidneys; laboratory animals; lethal dose 50; liver; mice; oral administration; rambutans; rats; subacute toxicity; tissues;     Show all 15 Subjects
Abstract:
... Acute and subacute studies of rambutan peel phenolic (RPP) extract were conducted by oral administration on Kunming mice and Sprague-Dawley (SD) rats, respectively. Acute toxicity study (14 days) results revealed that the LD₅₀ value of RPP extract was more than 5000 mg/kg bw in vivo. For the subacute study, four different doses were administered to SD rats by daily gavage for 28 days. Subacute tox ...
DOI:
10.1016/j.foodchem.2020.126618