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1. Some Aspects Related to Transmission of Radiation-Induced Alterations due to the Bystander Effect

Author:
Petushkova, V. V.; Pelevina, I. I.; Kogarko, I. N.; Neifakh, E. A.; Kogarko, B. S.; Ktitorova, O. V.
Source:
Biology bulletin of the Russian Academy of Sciences 2020 v.47 no.12 pp. 1610-1617
ISSN:
1062-3590
Subject:
spleen,   etc   ; ; alopecia; fish; irradiation;     Show all 5 Subjects
Abstract:
... This paper presents the first results of research and observations within the framework of the Integrated Project for the assessment of radiation-induced nontargeted effects. The remote bystander effect, related to nontargeted effects, is one of the least studied phenomena in terms of manifestations and mechanisms. The international laboratory practice with respect to this phenomenon commenced wit ...
DOI:
10.1134/S1062359020120079

2. Ultrasonography of kidney and spleen in clinically healthy llamas and alpacas

Author:
Eibl, Cassandra; Franz, Sonja
Source:
Acta veterinaria scandinavica 2021 v.63 no.1 pp. 4
ISSN:
1751-0147
Subject:
spleen,   etc   ; alcohols; diagnostic techniques; kidneys; transducers (equipment); ultrasonics; ultrasonography;     Show all 7 Subjects
Abstract:
... BACKGROUND: The ultrasonographic examination technique is a well-established, non-invasive diagnostic tool for diverse conditions in humans and different animal species. The purpose of our study was to describe ultrasonographic localisation, sonographic appearance and dimensions of the kidneys and spleen of clinically healthy llamas and alpacas. Differences between llamas and alpacas and the influ ...
DOI:
10.1186/s13028-021-00571-5

3. Nuclear PTEN deficiency and heterozygous PTEN loss have distinct impacts on brain and lymph node size

Author:
Igarashi, Atsushi; Kato, Takashi; Sesaki, Hiromi; Iijima, Miho
Source:
Biochemical and biophysical research communications 2021 v.555 pp. 81-88
ISSN:
0006-291X
Subject:
spleen,   etc   ; brain; carcinogenesis; heterozygosity; liver; lymph nodes; lymphoma; neurons; research;     Show all 9 Subjects
Abstract:
... Defects in PTEN, a critical tumor suppressor, are associated with tumorigenesis and aberrant organ sizes. It has been shown that heterozygous PTEN loss increases brains and neuron size, while the specific loss of nuclear PTEN has the opposite effect. Here, we investigate the impact of a combination of heterozygous PTEN loss and nuclear PTEN loss on the size of various organs, including the brain, ...
DOI:
10.1016/j.bbrc.2021.03.081

4. Feline abdominal ultrasonography: What’s normal? What’s abnormal? The spleen

Author:
Griffin, Sally
Source:
Journal of feline medicine and surgery 2021 v.23 no.3 pp. 241-255
ISSN:
1532-2750
Subject:
spleen,   etc   ; cats; diagnostic techniques; medicine; surgery; ultrasonics; ultrasonography;     Show all 7 Subjects
Abstract:
... Abdominal ultrasound plays a vital role in the diagnostic work-up of many cats presenting to general and specialist practitioners. Ultrasound examination of the spleen provides important information to aid the investigation of several conditions and is particularly relevant when an enlarged or irregular spleen is identified during abdominal palpation. Despite ultrasonography being a commonly used ...
DOI:
10.1177/1098612X21993658

5. Effect of engineered superparamagnetic iron oxide nanoparticles in targeted cardiac precursor cell delivery by MRI

Author:
Chelluri, Lakshmi Kiran; Mohanram, Yamuna; Jain, Rashi; Mallarpu, Chandra Shekar; Ponnana, Meenakshi; Kumar, Deepak; Krishna Venuganti, Venkata Vamsi; Kancherla, Ravindranath; Papineni, Rao VL.; Towner, Rheal; Ghosal, Partha
Source:
Biochemical and biophysical research communications 2021 v.541 pp. 15-21
ISSN:
0006-291X
Subject:
spleen,   etc   ; heart failure; iron oxides; liver; magnetism; regulatory proteins; research;     Show all 7 Subjects
Abstract:
... A scientific approach is presented describing the fabrication of nanoprobe (GloTrack) that can act as cardiac precursor label to segregate cells from cardiac/non cardiac origins and traced by magnetic resonance imaging (MRI). Signal regulatory protein alpha (SIRPA) and kinase domain receptor (KDR) recognizing antibodies, form a layer on super paramagnetic iron oxide nanoparticle – poly-ethylene gl ...
DOI:
10.1016/j.bbrc.2021.01.005

6. A New Deletion of Mitochondrial DNA of a BALB/c Mouse

Author:
Antipova, V. N.
Source:
Russian journal of genetics 2021 v.57 no.2 pp. 246-249
ISSN:
1022-7954
Subject:
spleen,   etc   ; blood; brain; heart; males; mice; mitochondrial DNA;     Show all 7 Subjects
Abstract:
... A large deletion of mitochondrial DNA 7653 bp long has been identified in tissues of the brain, the spleen, the heart, and peripheral blood of a BALB/c male mouse. ...
DOI:
10.1134/S1022795421020022

7. A putative telomerase activator has tissue‐specific effects on telomere length in a developing songbird

Author:
Wolf, Sarah E.; Stansberry, Keegan R.; Content, Kristen R.; Rosvall, Kimberly A.
Source:
Journal of avian biology 2021 v.52 no.2
ISSN:
0908-8857
Subject:
spleen,   etc   ; Tachycineta bicolor; blood; brain; liver; longevity; songbirds; telomerase; telomeres;     Show all 9 Subjects
Abstract:
... There is good evidence that telomeres predict variation in health and longevity, yet it is unclear whether these patterns are causally derived from telomeres per se, in part because relatively little research directly manipulates telomere length during early life, when telomere shortening is most dynamic. Here, we test how the telomerase activator TA‐65 (i.e. cycloastrogenol) affects telomere leng ...
DOI:
10.1111/jav.02639

8. Complementing Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging with Chromatography Data for Improved Assignment of Isobaric and Isomeric Phospholipids Utilizing Trapped Ion Mobility-Mass Spectrometry

Author:
Helmer, Patrick O.; Nordhorn, Ilona D.; Korf, Ansgar; Behrens, Arne; Buchholz, Rebecca; Zubeil, Florian; Karst, Uwe; Hayen, Heiko
Source:
Analytical chemistry 2021 v.93 no.4 pp. 2135-2143
ISSN:
1520-6882
Subject:
spleen,   etc   ; analytical chemistry; databases; desorption; glycerophospholipids; hydrophilicity; ionization; mice; phosphates;     Show all 9 Subjects
Abstract:
... Lipids, such for example the multifaceted category of glycerophospholipids (GP), play a major role in many biological processes. High-resolution mass spectrometry is able to identify these highly diverse lipid species in combination with fragmentation experiments (MS/MS) on the basis of the accurate m/z and fragmentation pattern. However, for the differentiation of isomeric lipids or isobaric inte ...
DOI:
10.1021/acs.analchem.0c03942

9. Molecular Identification and mRNA Expression Profiles of Galectin-9 Gene in Red Sea Bream (Pagrus major) Infected with Pathogens

Author:
Choi, Kwang-Min; Joo, Min-Soo; Cho, Dong-Hee; Woo, Won-Sik; Kang, Gyoungsik; Heo, Min Jin; Kim, Do-Hyung; Park, Chan-Il
Source:
Animals 2021 v.11 no.1
ISSN:
2076-2615
Subject:
Infectious spleen and kidney necrosis virus; spleen,   etc   ; ; Edwardsiella piscicida; Pagrus major; Sparus aurata; Streptococcus iniae; carbohydrates; galectins; gene expression; genes; intestines; kidneys; ligands; pathogens; phylogeny;     Show all 16 Subjects
Abstract:
... Galectin (Gal) is a member of a family of β-galactoside-binding lectin. The members of this family play important roles in the recognition of carbohydrate ligands and in various other biological processes. In this study, we identified the gene encoding Gal-9 in Pagrus major (PmGal-9) and analyzed its expression in various tissues after pathogen challenge. Alignment analysis revealed that the two g ...
DOI:
10.3390/ani11010139

10. Time-dependent increase of plasma cGMP concentration followed by oral EGCG administration in mice

Author:
Tanaka, Yasutake; Kumazoe, Motofumi; Onda, Hiroaki; Fujimura, Yoshinori; Tachibana, Hirofumi
Source:
Food bioscience 2021 v.41 pp. 101017
ISSN:
2212-4292
Subject:
spleen,   etc   ; animals; blood; catechin; cyclic GMP; epigallocatechin gallate; green tea; oral administration; second messengers;     Show all 9 Subjects
Abstract:
... Epigallocatechin 3-O-gallate (EGCG), the major catechin in green tea, exerts several beneficial effects in vivo. A previous study showed that cyclic guanosine monophosphate (cGMP) as a cellular second messenger has been shown to be an important mediator of the effects of EGCG. In general, long-term animal experiments are required to evaluate the functionality of phytochemicals such as EGCG. Thus, ...
DOI:
10.1016/j.fbio.2021.101017

11. Discrete binding patterns of two heparin-reactive proteins, basic fibroblast growth factor and peptide p5R, in amyloid-laden and healthy mice

Author:
Martin, Emily B.; Donnell, Robert; Richey, Tina; Stuckey, Alan; Kennel, Stephen J.; Wall, Jonathan S.
Source:
Biochemical and biophysical research communications 2021 v.552 pp. 136-141
ISSN:
0006-291X
Subject:
spleen,   etc   ; amyloid; amyloidosis; extracellular matrix; fibroblast growth factor 2; heparan sulfate; liver; peptides; proteoglycans; radiolabeling; research;     Show all 11 Subjects
Abstract:
... Peptide p5R is a synthetic, polybasic, heparin-binding peptide that preferentially reacts with amyloid deposits in vivo and in tissue sections. Basic fibroblast growth factor (bFGF¹) similarly interacts with heparin-like molecules, notably heparan sulfate proteoglycans (HSPG), in the extracellular matrix and on cell surfaces. The aim of this study was to compare the biodistribution of p5R and bFGF ...
DOI:
10.1016/j.bbrc.2021.03.054

12. Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels

Author:
Ishii, Naoki; Homma, Takujiro; Takeda, Yuji; Aung, Naing Ye; Yamada, Ken-ichi; Miyata, Satoshi; Asao, Hironobu; Yamakawa, Mitsunori; Fujii, Junichi
Source:
The Journal of nutritional biochemistry 2021 v.91 pp. 108604
ISSN:
0955-2863
Subject:
spleen,   etc   ; ; adulthood; aldehyde reductase; aldehydes; apoptosis; ascorbic acid; atrophy; biosynthesis; corticosterone; females; genes; growth retardation;     Show all 13 Subjects
Abstract:
... Aldehyde reductase encoded by the Akr1a gene catalyzes the NADPH-dependent reduction of a variety of aldehyde compounds, and it plays a role in the biosynthesis of ascorbic acid (AsA) by converting D-glucuronate to L-gulonate. Although supplementing drinking water with AsA (1.5 mg/mL) ameliorates the fertility of Akr1a⁻/⁻ (KO) female mice, litter sizes in the KO mice are typically smaller than tho ...
DOI:
10.1016/j.jnutbio.2021.108604

13. Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging

Author:
Tao, Li; Zhang, Wei; Zhang, Yaxin; Zhang, Mei; Zhang, Yueying; Niu, Xing; Zhao, Qing; Liu, Zhenxing; Li, Yuyin; Diao, Aipo
Source:
Food & function 2021 v.12 no.7 pp. 2914-2924
ISSN:
2042-650X
Subject:
spleen,   etc   ; animals; caffeine; cell senescence; decline; histology; length; liver; tea; telomerase; telomeres;     Show all 11 Subjects
Abstract:
... Telomere shortening is one of the main causes of cellular senescence. Caffeine is a natural stimulant most commonly found in coffee and tea. In this study, caffeine was found to promote the expression of telomerase reverse transcriptase (TERT) at both mRNA and protein levels, and consequently extended the telomere length and prevented cellular senescence. Knockdown of TERT eliminated the effect of ...
DOI:
10.1039/d0fo03246h

14. Generation of αCD11b-CpG antibody conjugates for the targeted stimulation of myeloid cells

Author:
Balneger, N.; Kroesen, M.; Lindau, D.; Wassink, M.; Boon, L.; den Brok, M.H.; Büll, C.; Adema, G.J.
Source:
Journal of controlled release 2021 v.332 pp. 148-159
ISSN:
0168-3659
Subject:
spleen,   etc   ; DNA; Toll-like receptor 9; adjuvants; blood; hypersensitivity; immunity; intravenous injection; lymph; mice; oligodeoxyribonucleotides;     Show all 11 Subjects
Abstract:
... CpG oligonucleotides are short single-stranded synthetic DNA molecules. Upon binding to Toll-like receptor 9 (TLR9), CpG activates immune cells in humans and mice. This results in robust Th1 type immunity potentially resulting in clearance of pathogens, reduction of allergy and anti-tumor immunity. However, the effectiveness of CpG as an adjuvant depends on its administration route, with only stro ...
DOI:
10.1016/j.jconrel.2021.02.017

15. Characterization and evaluation of the tissue distribution of CRH, apelin, and GnRH2 reveal responses to feeding states in Schizothorax davidi

Author:
Yuan, Dengyue; Wang, Bin; Tang, Tao; Lei, Luo; Zhou, Chaowei; Li, Zhiqiong; Li, Lijun
Source:
Fish physiology and biochemistry 2021 v.47 no.2 pp. 421-438
ISSN:
0920-1742
Subject:
spleen,   etc   ; ; Schizothorax; appetite; aquaculture; energy; fish; heart; hypothalamus; refeeding; tissue distribution; China;     Show all 12 Subjects
Abstract:
... Schizothorax davidi is a rare fish in Southwest China and is considered a promising species for aquaculture. Compared with other teleosts, little is known about the endocrine regulation of feeding in this species. In this study, we identified the CRH, apelin, and GnRH2 genes in S. davidi and assessed the effects of different energy statuses on CRH, apelin, and GnRH2 expression. Our results showed ...
DOI:
10.1007/s10695-020-00922-5

16. Extra-hepatopulmonary cystic echinococcosis in Bulgaria: frequency, management and outcome of the disease

Author:
Harizanov, Rumen N.; Rainova, Iskra G.; Kaftandjiev, Iskren T.
Source:
Parasitology 2021 v.148 no.5 pp. 562-565
ISSN:
1469-8161
Subject:
spleen,   etc   ; abdominal cavity; echinococcosis; females; humans; liver; lungs; muscles; parasitology; therapeutics; Bulgaria;     Show all 11 Subjects
Abstract:
... In the endemic countries, human cystic echinococcosis (CE) poses a serious medical and social problem. Because it most often affects the liver and lungs we aimed to define the proportion of cases with different organ localization, the diagnostic and therapeutic approaches in such cases, and the outcome of them. For a period 2010–2019, a total of 2863 cases of CE were registered in Bulgaria, of whi ...
DOI:
10.1017/S0031182020002206

17. Renal embryonal nephroma exhibiting malignant features in a Dutch rabbit (Oryctolagus cuniculus)

Author:
Sabater, Mikel; Mancinelli, Elisabetta; Denk, Daniela
Source:
Journal of exotic pet medicine 2021 v.37 pp. 18-21
ISSN:
1557-5063
Subject:
spleen,   etc   ; Nephroma; Oryctolagus cuniculus; abdomen; adipose tissue; histopathology; hyperemia; kidneys; males; medicine; metastasis; neoplasms; rabbits; ultrasonography;     Show all 14 Subjects
Abstract:
... Benign embryonal nephromas have been documented in rabbits. However, only one case of nephroblastoma with concurrent metastasis (pulmonary), a postmortem incidental finding, has been published.A 3-year-old neutered male Dutch rabbit (Oryctolagus cuniculus) was referred for assessment of a firm mass located in the mid-dorsal abdomen. Abdominal ultrasonography confirmed a large soft tissue mass of s ...
DOI:
10.1053/j.jepm.2021.01.001

18. Tissue-specific effect of colitis on protein synthesis in mice: impact of the dietary protein content

Author:
Vidal-Lletjós, Sandra; Khodorova, Nadezda V.; Piscuc, Maria; Gaudichon, Claire; Blachier, François; Lan, Annaïg
Source:
European journal of nutrition 2021 v.60 no.3 pp. 1669-1677
ISSN:
1436-6207
Subject:
spleen,   etc   ; anabolism; cecum; colitis; colon; dietary protein; energy; inflammation; liver; muscles; protein content; protein synthesis; valine;     Show all 13 Subjects
Abstract:
... PURPOSE: Inflammatory bowel diseases are associated with an increase in the whole-body protein turnover, thus possibly requiring an additional supply of dietary proteins. Our aim was to evaluate whether increasing dietary protein content could alleviate protein metabolism alterations in the injured splanchnic and peripheral tissues during colitis and spontaneous mucosal healing. METHODS: Mice with ...
DOI:
10.1007/s00394-020-02365-3

19. The immune efficacy of a Streptococcus agalactiae immersion vaccine for different sizes of young tilapia

Author:
Ke, Xiaoli; Liu, Zhigang; Chen, Shanzhen; Chen, Zhiting; Zhang, Defeng; Gao, Fengying; Lu, Maixin
Source:
Aquaculture 2021 v.534 pp. 736289
ISSN:
0044-8486
Subject:
spleen,   etc   ; Streptococcus agalactiae; antibodies; antigens; aquaculture; fish skin; gene expression regulation; intestines; kidneys; liver; oropharynx; vaccines;     Show all 12 Subjects
Abstract:
... In order to explore the immune efficacy of a Streptococcus agalactiae immersion vaccine for young tilapia, three sizes of tilapia were selected and immunized a single time with an S. agalactiae immersion vaccine. The results that showed the whole cell antigen was crushed into nanoparticles and positive signals of antigen uptake were found in different sizes of tilapia and were mainly distributed i ...
DOI:
10.1016/j.aquaculture.2020.736289

20. Anti-aging effect of Lactobacillus plantarum HFY09-fermented soymilk on D-galactose-induced oxidative aging in mice through modulation of the Nrf2 signaling pathway

Author:
Zhou, Xianrong; Sun, Hailan; Tan, Fang; Yi, Ruokun; Zhou, Chaolekang; Deng, Yuhan; Mu, Jianfei; Zhao, Xin
Source:
Journal of functional foods 2021 v.78 pp. 104386
ISSN:
1756-4646
Subject:
spleen,   etc   ; Lactobacillus plantarum; anti-aging properties; blood serum; brain; hyaluronic acid; isoflavones; liver; peptides; soybeans; soymilk;     Show all 11 Subjects
Abstract:
... After soymilk fermented by L. plantarum HFY09, the bound soybean isoflavones content was reduced, but free soybean isoflavones and peptides increased. In vivo results show that L. plantarum HFY09-fermented soymilk increased the T-SOD, MDA, GSH-Px, GSH, CAT, and NO in the serum, liver, and brain tissues of mice. The aforementioned soymilk also increased the Col I and hyaluronic acid, and reduced th ...
DOI:
10.1016/j.jff.2021.104386