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spleen, etc ; carcinoma; hepatitis; hepatoma; immune response; mice; pharmacology; Show all 7 Subjects
Abstract:
... The infiltration of immune cells into the hepatocellular carcinoma microenvironment is the main reason why hepatocellular carcinoma patients are prone to carcinoma recurrence and the disease are incurable. Notably, the infiltration of Treg cells is the main trigger. Dahuang Zhechong pill (DHZCP) is a traditional Chinese herbal compound successful in the treatment of hepatitis and hepatocellular ca ...
spleen, etc ; death; horses; kidneys; liver; mass spectrometry; metabolites; stomach; Show all 8 Subjects
Abstract:
... Analytical detection of Oenanthe crocata toxins in biological samples is challenging because of their instability, the lack of commercially available standards and the exceptionally low detection of these molecules using mass spectrometry. This work aims to report the used analytical methods that allowed identification of the main plant toxins in biological samples from an equid (an Arabian horse) ...
M. Monteiro; P. Perdiguero; A. Couto; C.R. Serra; P. Pereiro; B. Novoa; A. Figueras; L. Ribeiro; P. Pousão-Ferreira; C. Tafalla; A. Oliva-Teles; P. Enes; C.J. Secombes; P. Díaz-Rosales
spleen, etc ; Argyrosomus regius; aquaculture; fish; immunology; lipopolysaccharides; sequence analysis; shellfish; transcriptome; Show all 9 Subjects
Abstract:
... Meagre (Argyrosomus regius) belongs to the family Sciaenidae and is a promising candidate for Mediterranean aquaculture diversification. As a relatively recent species in aquaculture, the physiological consequences of the immune system activation in meagre are understudied. Spleen, as a primary lymphoid organ has an essential role in meagre immune and inflammatory responses. In this study, we have ...
spleen, etc ; agricultural industry; atrazine; bioactive compounds; inflammasomes; lycopene; oxidative stress; pyroptosis; Show all 8 Subjects
Abstract:
... Nlrp3 is a vital integration point of diverse extracellular stimuli and cellular stress. However, the inappropriate activation of Nlrp3 results in the progression of autoinflammatory and metabolic disorders. Atrazine, which is used widely in the agricultural sector, is toxic to humans. Herein, this study found that atrazine could induce oxidative stress and the expression of Nfkb and IRF1 in splee ...
Infectious spleen and kidney necrosis virus; spleen, etc ; Rhabdoviridae; Siniperca chuatsi; amino acid sequences; brain; fish; glutamine; immunology; kidneys; metabolism; open reading frames; protein content; shellfish; transcription factors; virus replication; Show all 16 Subjects
Abstract:
... c-Myc is a transcription factor and master regulator of cellular metabolism, and plays a critical role in virus replication by regulating glutamine metabolism. In this study, the open-reading frame (ORF) of c-Myc, designated as Sc-c-Myc, was cloned and sequenced. Multiple alignment of the amino acid sequence showed that the conserved domain of Sc-c-Myc, including the helix–loop–helix-zipper (bHLHz ...
spleen, etc ; Salmonella; antibiotics; broiler breeders; competitive exclusion; lactic acid; salmonellosis; weight gain; Show all 8 Subjects
Abstract:
... Non-typhoidal Salmonella spp. cause persistent asymptomatic infections in poultry. The consumption of Salmonella-infected poultry products is associated with food poisoning. One of the pathogens that causes such infections is Salmonella ser. Enteritidis (SE). Therefore, alternative measures are required for better control of salmonellosis and to reduce potential antibiotic use. Here, the efficacy ...
spleen, etc ; colitis; colon; dextran sulfate; glucosylceramides; lymph; microarray technology; pathogenesis; research; therapeutics; Show all 10 Subjects
Abstract:
... Inflammatory bowel disease (IBD) is a chronic inflammatory disease in the colon characterized by excessive activation of T cells. Glycosphingolipids (GSLs) are composed of lipid rafts in cellular membranes, and their content is linked to immune cell function. In the present study, we investigated the involvement of GSLs in IBD. Microarray data showed that in IBD patients, the expression of only UD ...
Torben Rehn; Pedro Lubiana; Thi Huyen Trang Nguyen; Eva Pansegrau; Marius Schmitt; Lisa Katharina Roth; Jana Brehmer; Thomas Roeder; Dániel Cadar; Nahla Galal Metwally; Iris Bruchhaus
spleen, etc ; Plasmodium falciparum; Plasmodium vivax; endothelial cells; erythrocyte membrane; genetically modified organisms; reticulocytes; Show all 7 Subjects
Abstract:
... Plasmodium falciparum-infected erythrocytes (PfIEs) adhere to endothelial cell receptors (ECRs) of blood vessels mainly via PfEMP1 proteins to escape elimination via the spleen. Evidence suggests that P. vivax-infected reticulocytes (PvIRs) also bind to ECRs, presumably enabled by VIR proteins, as shown by inhibition experiments and studies with transgenic P. falciparum expressing vir genes. To te ...
spleen, etc ; CD4-positive T-lymphocytes; bioinformatics; chemokine CXCL4; coculture; humans; immunity; lymph; mice; Show all 9 Subjects
Abstract:
... BACKGROUND AND AIM: Platelets are an able regulator of CD4⁺ T cell immunity. Herein, the mechanisms underlying platelet-regulated effector responses of naïve CD4⁺ T (Tn) cells were investigated. METHODS: Platelet–Tn cell co-cultures of human cells, genetically modified murine models, and high-throughput bioinformatic analyses were combined to elucidate molecular mechanisms of platelet-dependent re ...
spleen, etc ; Leptospira; anaphylaxis; cardiomyopathy; death; discoloration; dogs; females; histology; humans; myocardium; necropsy; vaccination; Show all 13 Subjects
Abstract:
... A 5-year-old female Springer Spaniel dog was submitted for necropsy after sudden death following vaccination against Leptospira spp. Gross examination revealed a diffuse dark red discolouration of skeletal musculature, severe diffuse congestion of all the abdominal organs and a contracted spleen. Severe dilation and reduction in wall width was seen in the right ventricle and histological examinati ...
... Mandarin fish (Siniperca chuatsi) been seriously harmed by infectious spleen and kidney necrosis virus (ISKNV) in recent years, but the early immune response mechanism of infection is still unknown. Here, we performed RNA sequencing on the spleens of mandarin fish infected with ISKNV at 0, 12, 24, 48, and 72 h post-infection (hpi) using short-read Illumina RNA sequencing and long-read Pacific Bios ...
spleen, etc ; Western blotting; bone marrow; enzymes; exons; kidneys; macrophages; mice; molecular biology; monocytes; neutrophils; splenocytes; Show all 12 Subjects
Abstract:
... Immune cells express the vitamin D receptor (VDR) and are therefore vitamin D targets. The Vdr protein can be readily measured in the kidney using antibodies to the Vdr and western blot. It is much more difficult to measure Vdr protein in the spleen because of the low level of VDR expression in resting immune cells. In order to more sensitively measure VDR expression, the Cre enzyme was inserted i ...
spleen, etc ; antagonism; blood serum; chromium; immunosuppression; inflammation; interleukin-2; oxidative stress; potassium; selenium; toxicity; yeasts; Show all 12 Subjects
Abstract:
... This study was conducted to investigate the molecular mechanisms of selenium (Se) antagonism of hexavalent chromium (Cr⁶⁺)-induced toxicity. Potassium dichromate (K₂Cr₂O₇) and selenium-enriched yeast (SeY) were used to construct the single Cr⁶⁺ and combined Se/Cr⁶⁺ exposure broiler models, and then the broilers were randomly divided into four groups (C group, Se group, Se/Cr⁶⁺ group, and Cr⁶⁺ grou ...
... Dietary long chain polyunsaturated n-3 fatty acids (n-3 FA) may be beneficial to broiler breeder (BB) development. Therefore, the effects of feeding sources of docosahexaenoic acid (DHA) and α-linolenic acid (ALA) from hatch through to 22 weeks of age (woa) on growth, organ weight, and jejunal histomorphology were investigated. A total of 588-day-old Ross × Ross 708 BB were reared on one of 3 diet ...
... Pseudorabies virus (PRV), also known as suid Alphaherpesvirus 1 (SuHV-1), which is one of the most devastating infectious pathogen of swine industry worldwide. Vaccination is the safest and most effective PRV prevention and control strategy. B cell receptor (BCR) is membrane-bound immunoglobulin located on the surface of B cells capable of specifically binding foreign antigens, which is one of the ...
... Coccidiosis, caused by Eimeria protozoan species, is an economically important enteric disease of poultry. Although commercial live vaccines are widely used for disease control, the vaccine-induced protective immune mechanisms are poorly characterized. The present study used a commercial broiler vaccine containing a mixture of E. acervulina, E. maxima, and E. tenella. One-day-old chicks were vacci ...
... α-Lactalbumin (BLA) and β-lactoglobulin (BLG) are the major whey proteins causing allergic reactions. Polyunsaturated fatty acids (PUFAs) stand among the extrinsic factors of the food matrix that can bind BLA and BLG and change their bioactivities, but their contribution to change the allergenic properties of these proteins has not been investigated. Here, we aimed to determine how PUFAs influence ...
spleen, etc ; Procypris rabaudi; body length; exercise; fish; juveniles; lysozyme; metabolism; predation; specific growth rate; survival rate; Show all 11 Subjects
Abstract:
... Many studies have found that aerobic exercise training at a moderate water velocity can improve the growth, swimming performance and survival rate of fish. To investigate the effects of aerobic exercise training on the growth, swimming performance, antipredation ability and immune parameters of rock carp, juveniles were placed in training channels with different water velocities (i.e., 3 cm s⁻¹, 1 ...
... Red sea bream iridovirus (RSIV) is an emerging viral pathogen having significant socio-economic and environmental impacts on marine and brackish aquaculture systems. The study documents certain interesting findings of an RSIV disease outbreak that caused 50% cumulative mortality among cage farmed Asian sea bass in India. The confirmatory diagnosis was made based on internationally approved protoco ...
spleen, etc ; CXCR4 receptor; antineoplastic activity; biocompatible materials; bone marrow; drug therapy; liver; mice; myeloid leukemia; nanomedicine; toxicity; Show all 11 Subjects
Abstract:
... Current therapy in acute myeloid leukemia (AML) is based on chemotherapeutic drugs administered at high doses, lacking targeting selectivity and displaying poor therapeutic index because of severe adverse effects. Here, we develop a novel nanoconjugate that combines a self-assembled, multivalent protein nanoparticle, targeting the CXCR4 receptor, with an Oligo-Ara-C prodrug, a pentameric form of A ...