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1. Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance

Author:
Tian-Tian CHEN; Sha-Li DU; Shi-Jun WANG; Li WU; Lu YIN
Source:
Chinese journal of natural medicines 2022 v.20 no.2 pp. 102-110
ISSN:
1875-5364
Subject:
spleen,   etc   ; carcinoma; hepatitis; hepatoma; immune response; mice; pharmacology;     Show all 7 Subjects
Abstract:
... The infiltration of immune cells into the hepatocellular carcinoma microenvironment is the main reason why hepatocellular carcinoma patients are prone to carcinoma recurrence and the disease are incurable. Notably, the infiltration of Treg cells is the main trigger. Dahuang Zhechong pill (DHZCP) is a traditional Chinese herbal compound successful in the treatment of hepatitis and hepatocellular ca ...
DOI:
10.1016/S1875-5364(22)60160-2

2. Analytical documentation of an Arabian horse fatality related to Oenanthe crocata poisoning

Author:
Alexandr Gish; Cynthia Robveille; Thomas Gicquel; Delphine Allorge; Gilbert Gault; Jean-Michel Gaulier
Source:
Toxicon 2022 v.210 pp. 39-43
ISSN:
0041-0101
Subject:
spleen,   etc   ; death; horses; kidneys; liver; mass spectrometry; metabolites; stomach;     Show all 8 Subjects
Abstract:
... Analytical detection of Oenanthe crocata toxins in biological samples is challenging because of their instability, the lack of commercially available standards and the exceptionally low detection of these molecules using mass spectrometry. This work aims to report the used analytical methods that allowed identification of the main plant toxins in biological samples from an equid (an Arabian horse) ...
DOI:
10.1016/j.toxicon.2022.02.009

3. Comprehensive transcriptome profiling and functional analysis of the meagre (Argyrosomus regius) immune system

Author:
M. Monteiro; P. Perdiguero; A. Couto; C.R. Serra; P. Pereiro; B. Novoa; A. Figueras; L. Ribeiro; P. Pousão-Ferreira; C. Tafalla; A. Oliva-Teles; P. Enes; C.J. Secombes; P. Díaz-Rosales
Source:
Fish & shellfish immunology 2022 v.123 pp. 506-520
ISSN:
1050-4648
Subject:
spleen,   etc   ; Argyrosomus regius; aquaculture; fish; immunology; lipopolysaccharides; sequence analysis; shellfish; transcriptome;     Show all 9 Subjects
Abstract:
... Meagre (Argyrosomus regius) belongs to the family Sciaenidae and is a promising candidate for Mediterranean aquaculture diversification. As a relatively recent species in aquaculture, the physiological consequences of the immune system activation in meagre are understudied. Spleen, as a primary lymphoid organ has an essential role in meagre immune and inflammatory responses. In this study, we have ...
DOI:
10.1016/j.fsi.2022.03.033

4. Lycopene ameliorates atrazine-induced pyroptosis in spleen by suppressing the Ox-mtDNA/Nlrp3 inflammasome pathway

Author:
Shi-Yong Zhu; Jian-Ying Guo; Jin-Yang Li; Xue-Yan Dai; Xue-Nan Li; Jin-Long Li
Source:
Food & function 2022 v.13 no.6 pp. 3551-3560
ISSN:
2042-650X
Subject:
spleen,   etc   ; agricultural industry; atrazine; bioactive compounds; inflammasomes; lycopene; oxidative stress; pyroptosis;     Show all 8 Subjects
Abstract:
... Nlrp3 is a vital integration point of diverse extracellular stimuli and cellular stress. However, the inappropriate activation of Nlrp3 results in the progression of autoinflammatory and metabolic disorders. Atrazine, which is used widely in the agricultural sector, is toxic to humans. Herein, this study found that atrazine could induce oxidative stress and the expression of Nfkb and IRF1 in splee ...
DOI:
10.1039/d1fo02857j

5. Characterization and function of mandarin fish c-Myc during viral infection process

Author:
Caimei Ye; Ningqiu Li; Yinjie Niu; Qiang Lin; Xia Luo; Hongru Liang; Lihui Liu; Xiaozhe Fu
Source:
Fish & shellfish immunology 2022 v.120 pp. 686-694
ISSN:
1050-4648
Subject:
Infectious spleen and kidney necrosis virus; spleen,   etc   ; Rhabdoviridae; Siniperca chuatsi; amino acid sequences; brain; fish; glutamine; immunology; kidneys; metabolism; open reading frames; protein content; shellfish; transcription factors; virus replication;     Show all 16 Subjects
Abstract:
... c-Myc is a transcription factor and master regulator of cellular metabolism, and plays a critical role in virus replication by regulating glutamine metabolism. In this study, the open-reading frame (ORF) of c-Myc, designated as Sc-c-Myc, was cloned and sequenced. Multiple alignment of the amino acid sequence showed that the conserved domain of Sc-c-Myc, including the helix–loop–helix-zipper (bHLHz ...
DOI:
10.1016/j.fsi.2021.12.045

6. Effectiveness of Administering a Mixture of Lactic Acid Bacteria to Control Salmonella ser. Enteritidis Infections in Broilers

Author:
Yu-Jin Kim; Sungsu Youk; Chang-Seon Song
Source:
Animals 2022 v.12 no.3 pp. -
ISSN:
2076-2615
Subject:
spleen,   etc   ; Salmonella; antibiotics; broiler breeders; competitive exclusion; lactic acid; salmonellosis; weight gain;     Show all 8 Subjects
Abstract:
... Non-typhoidal Salmonella spp. cause persistent asymptomatic infections in poultry. The consumption of Salmonella-infected poultry products is associated with food poisoning. One of the pathogens that causes such infections is Salmonella ser. Enteritidis (SE). Therefore, alternative measures are required for better control of salmonellosis and to reduce potential antibiotic use. Here, the efficacy ...
DOI:
10.3390/ani12030374

7. Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease

Author:
Mariko Komuro; Masaki Nagane; Rikito Endo; Takashi Nakamura; Takayoshi Miyamoto; Chiaki Niwa; Tomoki Fukuyama; Hideyoshi Harashima; Naoyuki Aihara; Junichi Kamiie; Rimina Suzuki; Tadashi Yamashita
Source:
Biochemical and biophysical research communications 2022 v.599 pp. 24-30
ISSN:
0006-291X
Subject:
spleen,   etc   ; colitis; colon; dextran sulfate; glucosylceramides; lymph; microarray technology; pathogenesis; research; therapeutics;     Show all 10 Subjects
Abstract:
... Inflammatory bowel disease (IBD) is a chronic inflammatory disease in the colon characterized by excessive activation of T cells. Glycosphingolipids (GSLs) are composed of lipid rafts in cellular membranes, and their content is linked to immune cell function. In the present study, we investigated the involvement of GSLs in IBD. Microarray data showed that in IBD patients, the expression of only UD ...
DOI:
10.1016/j.bbrc.2022.02.004

8. Ectopic Expression of Plasmodium vivax vir Genes in P. falciparum Affects Cytoadhesion via Increased Expression of Specific var Genes

Author:
Torben Rehn; Pedro Lubiana; Thi Huyen Trang Nguyen; Eva Pansegrau; Marius Schmitt; Lisa Katharina Roth; Jana Brehmer; Thomas Roeder; Dániel Cadar; Nahla Galal Metwally; Iris Bruchhaus
Source:
Microorganisms 2022 v.10 no.6 pp. -
ISSN:
2076-2607
Subject:
spleen,   etc   ; Plasmodium falciparum; Plasmodium vivax; endothelial cells; erythrocyte membrane; genetically modified organisms; reticulocytes;     Show all 7 Subjects
Abstract:
... Plasmodium falciparum-infected erythrocytes (PfIEs) adhere to endothelial cell receptors (ECRs) of blood vessels mainly via PfEMP1 proteins to escape elimination via the spleen. Evidence suggests that P. vivax-infected reticulocytes (PvIRs) also bind to ECRs, presumably enabled by VIR proteins, as shown by inhibition experiments and studies with transgenic P. falciparum expressing vir genes. To te ...
DOI:
10.3390/microorganisms10061183

9. Platelets fine-tune effector responses of naïve CD4+ T cells via platelet factor 4-regulated transforming growth factor β signaling

Author:
Yanan Min; Long Hao; Xinguang Liu; Shuai Tan; Hui Song; Hao Ni; Zi Sheng; Natalie Jooss; Xuena Liu; Rickard E. Malmström; Yang Sun; Jianguo Liu; Hua Tang; Hao Zhang; Chunhong Ma; Jun Peng; Ming Hou; Nailin Li
Source:
Cellular and molecular life sciences 2022 v.79 no.5 pp. 247
ISSN:
1420-682X
Subject:
spleen,   etc   ; CD4-positive T-lymphocytes; bioinformatics; chemokine CXCL4; coculture; humans; immunity; lymph; mice;     Show all 9 Subjects
Abstract:
... BACKGROUND AND AIM: Platelets are an able regulator of CD4⁺ T cell immunity. Herein, the mechanisms underlying platelet-regulated effector responses of naïve CD4⁺ T (Tn) cells were investigated. METHODS: Platelet–Tn cell co-cultures of human cells, genetically modified murine models, and high-throughput bioinformatic analyses were combined to elucidate molecular mechanisms of platelet-dependent re ...
DOI:
10.1007/s00018-022-04279-1

10. Vaccine-Associated Anaphylactic Shock in a Springer Spaniel Dog with Arrhythmogenic Right Ventricular Cardiomyopathy

Author:
Luca Bertola; Andrea Cappelleri; Raffaella MA. Tomba; Elisa Dotti; Mario Caniatti; Paola Dall’Ara; Camilla Recordati
Source:
Journal of comparative pathology 2022 v.194 pp. 34-38
ISSN:
0021-9975
Subject:
spleen,   etc   ; Leptospira; anaphylaxis; cardiomyopathy; death; discoloration; dogs; females; histology; humans; myocardium; necropsy; vaccination;     Show all 13 Subjects
Abstract:
... A 5-year-old female Springer Spaniel dog was submitted for necropsy after sudden death following vaccination against Leptospira spp. Gross examination revealed a diffuse dark red discolouration of skeletal musculature, severe diffuse congestion of all the abdominal organs and a contracted spleen. Severe dilation and reduction in wall width was seen in the right ventricle and histological examinati ...
DOI:
10.1016/j.jcpa.2022.03.009

11. The dynamic immune responses of Mandarin fish (Siniperca chuatsi) to ISKNV in early infection based on full-length transcriptome analysis and weighted gene co-expression network analysis

Author:
Yu Zhou; Huang-Cui Fu; Ying-Ying Wang; He-Zhong Huang; Xiao-Zhe Fu; Ning-Qiu Li
Source:
Fish & shellfish immunology 2022 v.122 pp. 191-205
ISSN:
1050-4648
Subject:
Infectious spleen and kidney necrosis virus; spleen,   etc   ; Siniperca chuatsi; apoptosis; endocytosis; fish; gene expression regulation; genes; herpes simplex; immune response; interleukin-8; intestines; phagosomes; sequence analysis; shellfish; transcription factor NF-kappa B; transcriptome; transcriptomics; viruses;     Show all 19 Subjects
Abstract:
... Mandarin fish (Siniperca chuatsi) been seriously harmed by infectious spleen and kidney necrosis virus (ISKNV) in recent years, but the early immune response mechanism of infection is still unknown. Here, we performed RNA sequencing on the spleens of mandarin fish infected with ISKNV at 0, 12, 24, 48, and 72 h post-infection (hpi) using short-read Illumina RNA sequencing and long-read Pacific Bios ...
DOI:
10.1016/j.fsi.2022.02.017

12. Novel insight into the role of the vitamin D receptor in the development and function of the immune system

Author:
Arora Juhi; Wang Jinpeng; Weaver Veronika; Zhang Yongwei; Cantorna Margherita T.
Source:
The Journal of Steroid Biochemistry and Molecular Biology pp. -
ISSN:
0960-0760
Subject:
spleen,   etc   ; Western blotting; bone marrow; enzymes; exons; kidneys; macrophages; mice; molecular biology; monocytes; neutrophils; splenocytes;     Show all 12 Subjects
Abstract:
... Immune cells express the vitamin D receptor (VDR) and are therefore vitamin D targets. The Vdr protein can be readily measured in the kidney using antibodies to the Vdr and western blot. It is much more difficult to measure Vdr protein in the spleen because of the low level of VDR expression in resting immune cells. In order to more sensitively measure VDR expression, the Cre enzyme was inserted i ...
DOI:
10.1016/j.jsbmb.2022.106084
CHORUS:
10.1016/j.jsbmb.2022.106084

13. Selenium-Enriched Yeast Relieves Hexavalent Chromium Toxicity by Inhibiting NF-κB Signaling Pathway in Broiler Spleens

Author:
Yanbing Zhao; Dezheng Hao; Huan Zhang; Jingqiu Wang; Ci Liu
Source:
Animals 2022 v.12 no.2 pp. -
ISSN:
2076-2615
Subject:
spleen,   etc   ; antagonism; blood serum; chromium; immunosuppression; inflammation; interleukin-2; oxidative stress; potassium; selenium; toxicity; yeasts;     Show all 12 Subjects
Abstract:
... This study was conducted to investigate the molecular mechanisms of selenium (Se) antagonism of hexavalent chromium (Cr⁶⁺)-induced toxicity. Potassium dichromate (K₂Cr₂O₇) and selenium-enriched yeast (SeY) were used to construct the single Cr⁶⁺ and combined Se/Cr⁶⁺ exposure broiler models, and then the broilers were randomly divided into four groups (C group, Se group, Se/Cr⁶⁺ group, and Cr⁶⁺ grou ...
DOI:
10.3390/ani12020146

14. Body weight, organ development and jejunal histomorphology in broiler breeder pullets fed n-3 fatty acids enriched diets from hatch through to 22 weeks of age

Author:
Aizwarya Thanabalan; Elijah G. Kiarie
Source:
Poultry science 2022 v.101 no.1 pp. 101514
ISSN:
0032-5791
Subject:
spleen,   etc   ; broiler breeders; diet; docosahexaenoic acid; jejunum; linseed; liver; microalgae; omega-3 fatty acids; tissue weight;     Show all 10 Subjects
Abstract:
... Dietary long chain polyunsaturated n-3 fatty acids (n-3 FA) may be beneficial to broiler breeder (BB) development. Therefore, the effects of feeding sources of docosahexaenoic acid (DHA) and α-linolenic acid (ALA) from hatch through to 22 weeks of age (woa) on growth, organ weight, and jejunal histomorphology were investigated. A total of 588-day-old Ross × Ross 708 BB were reared on one of 3 diet ...
DOI:
10.1016/j.psj.2021.101514

15. Characterization of B cell receptor H-CDR3 repertoire of spleen in PRV-infected mice

Author:
Lishuang Deng; Fan Yang; Zhiwen Xu; Fengqin Li; Jun Zhao; Huidan Deng; Zhijie Jian; Siyuan Lai; Xiangang Sun; Ling Zhu
Source:
BMC veterinary research 2022 v.18 no.1 pp. 228
ISSN:
1746-6148
Subject:
spleen,   etc   ; B-lymphocytes; Suid alphaherpesvirus 1; adaptive immunity; immunoglobulins; pathogens; pork industry; vaccination; vaccines; veterinary medicine;     Show all 10 Subjects
Abstract:
... Pseudorabies virus (PRV), also known as suid Alphaherpesvirus 1 (SuHV-1), which is one of the most devastating infectious pathogen of swine industry worldwide. Vaccination is the safest and most effective PRV prevention and control strategy. B cell receptor (BCR) is membrane-bound immunoglobulin located on the surface of B cells capable of specifically binding foreign antigens, which is one of the ...
DOI:
10.1186/s12917-022-03340-2

16. Characterization of vaccine-induced immune responses against coccidiosis in broiler chickens

Author:
Carissa Gaghan; Daniel Adams; Javid Mohammed; Rocio Crespo; Kimberly Livingston; Raveendra R. Kulkarni
Source:
Vaccine 2022 v.40 no.28 pp. 3893-3902
ISSN:
0264-410X
Subject:
spleen,   etc   ; Protozoa; coccidiosis; disease control; gene expression; immunophenotyping; interferons; macrophage activation; macrophages; nitric oxide; oocysts; vaccination;     Show all 12 Subjects
Abstract:
... Coccidiosis, caused by Eimeria protozoan species, is an economically important enteric disease of poultry. Although commercial live vaccines are widely used for disease control, the vaccine-induced protective immune mechanisms are poorly characterized. The present study used a commercial broiler vaccine containing a mixture of E. acervulina, E. maxima, and E. tenella. One-day-old chicks were vacci ...
DOI:
10.1016/j.vaccine.2022.05.043

17. Dietary Linolenic Acid Increases Sensitizing and Eliciting Capacities of Cow’s Milk Whey Proteins in BALB/c Mice

Author:
Xuanyi Meng; Yong Wu; Xuefang Wen; Jinyan Gao; Yanhai Xie; Xiaoli Zhao; Jin Yuan; Hao Yang; Zheling Zeng; Xin Li; Hongbing Chen
Source:
Nutrients 2022 v.14 no.4 pp. -
ISSN:
2072-6643
Subject:
spleen,   etc   ; allergenicity; cows; crosslinking; cytokines; food matrix; hypersensitivity; immune response; mast cells; milk; models; spectroscopy; whey;     Show all 13 Subjects
Abstract:
... α-Lactalbumin (BLA) and β-lactoglobulin (BLG) are the major whey proteins causing allergic reactions. Polyunsaturated fatty acids (PUFAs) stand among the extrinsic factors of the food matrix that can bind BLA and BLG and change their bioactivities, but their contribution to change the allergenic properties of these proteins has not been investigated. Here, we aimed to determine how PUFAs influence ...
DOI:
10.3390/nu14040822

18. Effects of Aerobic Exercise Training on the Growth, Swimming Performance, Antipredation Ability and Immune Parameters of Juvenile Rock Carp (Procypris rabaudi)

Author:
Qimiao Hou; Shijian Fu; Tiji Huang; Xiuming Li; Xiaotao Shi
Source:
Animals 2022 v.12 no.3 pp. -
ISSN:
2076-2615
Subject:
spleen,   etc   ; Procypris rabaudi; body length; exercise; fish; juveniles; lysozyme; metabolism; predation; specific growth rate; survival rate;     Show all 11 Subjects
Abstract:
... Many studies have found that aerobic exercise training at a moderate water velocity can improve the growth, swimming performance and survival rate of fish. To investigate the effects of aerobic exercise training on the growth, swimming performance, antipredation ability and immune parameters of rock carp, juveniles were placed in training channels with different water velocities (i.e., 3 cm s⁻¹, 1 ...
DOI:
10.3390/ani12030257

19. Red sea bream iridovirus infection in cage farmed Asian sea bass (Lates calcarifer): Insights into the pathology, epizootiology, and genetic diversity

Author:
T.G. Sumithra; S.R. Krupesha Sharma; L. Neelima; N.R. Dhanutha; Aswathy Joshy; V.N. Anusree; S. Gayathri; R.K. Raghu; N.D. Praveen; Sujitha Thomas; K.M. Rajesh
Source:
Aquaculture 2022 v.548 pp. 737571
ISSN:
0044-8486
Subject:
Infectious spleen and kidney necrosis virus; spleen,   etc   ; Lates calcarifer; Vibrio alginolyticus; Vibrio fluvialis; adenosinetriphosphatase; anemia; brain; cages; carrier state; disease outbreaks; genes; genetic variation; host range; immune response; kidneys; liver; mortality; pathogenesis; pathogens; quarantine; socioeconomics; splenomegaly; transmission electron microscopy; viruses; India;     Show all 26 Subjects
Abstract:
... Red sea bream iridovirus (RSIV) is an emerging viral pathogen having significant socio-economic and environmental impacts on marine and brackish aquaculture systems. The study documents certain interesting findings of an RSIV disease outbreak that caused 50% cumulative mortality among cage farmed Asian sea bass in India. The confirmatory diagnosis was made based on internationally approved protoco ...
DOI:
10.1016/j.aquaculture.2021.737571

20. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model

Author:
Victor Pallarès; Ugutz Unzueta; Aïda Falgàs; Anna Aviñó; Yáiza Núñez; Annabel García-León; Laura Sánchez-García; Naroa Serna; Alberto Gallardo; Lorena Alba-Castellón; Patricia Álamo; Jorge Sierra; Lídia Cedó; Ramon Eritja; Antonio Villaverde; Esther Vázquez; Isolda Casanova; Ramon Mangues
Source:
Biomaterials 2022 v.280 pp. 121258
ISSN:
0142-9612
Subject:
spleen,   etc   ; CXCR4 receptor; antineoplastic activity; biocompatible materials; bone marrow; drug therapy; liver; mice; myeloid leukemia; nanomedicine; toxicity;     Show all 11 Subjects
Abstract:
... Current therapy in acute myeloid leukemia (AML) is based on chemotherapeutic drugs administered at high doses, lacking targeting selectivity and displaying poor therapeutic index because of severe adverse effects. Here, we develop a novel nanoconjugate that combines a self-assembled, multivalent protein nanoparticle, targeting the CXCR4 receptor, with an Oligo-Ara-C prodrug, a pentameric form of A ...
DOI:
10.1016/j.biomaterials.2021.121258