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1. An enzyme nanopocket based on covalent organic frameworks for long-term starvation therapy and enhanced photodynamic therapy of cancer

Author:
Wan, Xiuyan; Zhang, Huiwen; Pan, Wei; Li, Na; Tang, Bo
Source:
Chemical communications 2021 v.57 no.44 pp. 5402-5405
ISSN:
1364-548X
Subject:
starvation,   etc   ; catalase; glucose oxidase; photochemotherapy;     Show all 4 Subjects
Abstract:
... An enzyme nanopocket constructed from a porphyrin-based covalent organic framework (COF) was developed to co-load glucose oxidase (GOx) and catalase (CAT) for long-term starvation therapy and enhanced photodynamic therapy (PDT). ...
DOI:
10.1039/d0cc07544b

2. Differential Diagnosis of Cachexia and Refractory Cachexia and the Impact of Appropriate Nutritional Intervention for Cachexia on Survival in Terminal Cancer Patients

Author:
Nakajima, Nobuhisa
Source:
Nutrients 2021 v.13 no.3
ISSN:
2072-6643
Subject:
starvation,   etc   ; cachexia; nutritional intervention; prealbumin;     Show all 4 Subjects
Abstract:
... Cancer cachexia subsequently shifts to refractory cachexia, however, it is not easy to properly differentiate them in clinical settings. Patients considered refractory cachexia may include cachectic patients with starvation. This study aimed to identify these cachectic patients and to evaluate the effect of nutritional intervention for them. Study subjects were terminal cancer patients admitted fo ...
DOI:
10.3390/nu13030915

3. Changes of fluvial processes caused by the restoration of an incised mountain stream

Author:
Wyżga, Bartłomiej; Liro, Maciej; Mikuś, Paweł; Radecki-Pawlik, Artur; Jeleński, Józef; Zawiejska, Joanna; Plesiński, Karol
Source:
Ecological engineering 2021 v.168 pp. 106286
ISSN:
0925-8574
Subject:
starvation,   etc   ; floodplains; rivers; sediments; shear stress; streams;     Show all 6 Subjects
Abstract:
... The construction of a high check dam on mountain Krzczonówka Stream, Polish Carpathians, in the mid-20th century caused numerous detrimental changes to the downstream reach. In 2014 the check dam was lowered to make the structure passable for river biota. Before that, several block ramps were constructed in the deeply incised downstream reach to facilitate entrapment of the sediment expected to be ...
DOI:
10.1016/j.ecoleng.2021.106286

4. Programmed Flagellar Ejection in Caulobacter crescentus Leaves PL-subcomplexes

Author:
Kaplan, Mohammed; Wang, Yuhang; Chreifi, Georges; Zhang, Lujia; Chang, Yi-Wei; Jensen, Grant J.
Source:
Journal of molecular biology 2021 v.433 no.13 pp. 167004
ISSN:
0022-2836
Subject:
starvation,   etc   ; Caulobacter crescentus; flagellum; molecular biology;     Show all 4 Subjects
Abstract:
... The bacterial flagellum consists of a long extracellular filament that is rotated by a motor embedded in the cell envelope. While flagellar assembly has been extensively studied,¹ the disassembly process remains less well understood. In addition to the programmed flagellar ejection that occurs during the life cycle of Caulobacter crescentus, we and others have recently shown that many bacterial sp ...
DOI:
10.1016/j.jmb.2021.167004

5. High-Tech Training for Birds of Prey

Author:
Granati, Giovanni; Cichella, Francesca; Lucidi, Pia
Source:
Animals 2021 v.11 no.2
ISSN:
2076-2615
Subject:
starvation,   etc   ; altitude; habituation; risk; wild birds;     Show all 5 Subjects
Abstract:
... Raptors are some of the most at-risk groups of birds in the world and saving these top predators is essential for maintaining the health of many ecosystems. After hospitalization, raptors are often released when muscular recovery is still unfitting when they are unable to hunt efficiently and are at risk of dying from starvation within a few days. On the other hand, if a convalescent bird is train ...
DOI:
10.3390/ani11020530

6. A ratiometric fluorescent probe for monitoring pH fluctuations during autophagy in living cells

Author:
Wang, Shan; Wang, Bingya; Zhu, Lei; Hou, Ji-Ting; Yu, Kang-Kang
Source:
Chemical communications 2021 v.57 no.12 pp. 1510-1513
ISSN:
1364-548X
Subject:
starvation,   etc   ; autophagy; fluorescent dyes; pH; photostability;     Show all 5 Subjects
Abstract:
... We present a ratiometric fluorescent probe for monitoring pH featuring superb photostability and chemostability. The down-regulation of the intracellular pH during autophagy in living cells induced by various stimuli, including several drugs and starvation, was quantified, which could provide instructive value to construct autophagy models to study the related pathological processes. ...
DOI:
10.1039/d0cc07788g

7. Engineering of a robust Escherichia coli chassis and exploitation for large-scale production processes

Author:
Ziegler, Martin; Zieringer, Julia; Döring, Clarissa-Laura; Paul, Liv; Schaal, Christoph; Takors, Ralf
Source:
Metabolic engineering 2021 v.67 pp. 75-87
ISSN:
1096-7176
Subject:
starvation,   etc   ; Escherichia coli; gene deletion; glucose; phenotype; protein synthesis;     Show all 6 Subjects
Abstract:
... In large-scale bioprocesses microbes are exposed to heterogeneous substrate availability reducing the overall process performance. A series of deletion strains was constructed from E. coli MG1655 aiming for a robust phenotype in heterogeneous fermentations with transient starvation. Deletion targets were hand-picked based on a list of genes derived from previous large-scale simulation runs. Each g ...
DOI:
10.1016/j.ymben.2021.05.011

8. Cdc14 phosphatase downmodulates ESCRT-0 complex formation on vacuolar membranes and microautophagy after TORC1 inactivation

Author:
Sharmin, Tasnuva; Morshed, Shamsul; Tasnin, Most Naoshia; Takuma, Tsuneyuki; Ushimaru, Takashi
Source:
Biochemical and biophysical research communications 2021 v.561 pp. 158-164
ISSN:
0006-291X
Subject:
starvation,   etc   ; macroautophagy; mitosis; phosphorylation; protein kinases; rapamycin; research; vacuoles; yeasts;     Show all 9 Subjects
Abstract:
... Remodeling of vacuolar membranes mediated by endosomal sorting complex required for transport (ESCRT) is critical for microautophagy induction in budding yeast. Nutrient depletion and inactivation of target of rapamycin complex 1 (TORC1) protein kinase elicit recruitment of the ESCRT-0 complex (Vps27–Hse1) onto vacuolar membranes and ESCRT-mediated microautophagy induction. Mitotic protein phospha ...
DOI:
10.1016/j.bbrc.2021.05.021

9. Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling

Author:
Gergs, André; Hager, Jutta; Bruns, Eric; Preuss, Thomas G.
Source:
Environmental toxicology and chemistry 2021 v.40 no.6 pp. 1706-1712
ISSN:
0730-7268
Subject:
starvation,   etc   ; Chironomus riparius; chemistry; death; ecotoxicology; imidacloprid; mortality; thiacloprid;     Show all 8 Subjects
Abstract:
... Ecotoxicological profiles of the 3 insecticides imidacloprid, thiacloprid, and flupyradifurone in terms of acute and chronic effects were analyzed in Chironomus riparius. Toxicokinetic–toxicodynamic modeling revealed that chironomids would die from starvation as a result of prolonged feeding inhibition under chronic exposures. The starvation effect is an indirect cause for mortality, which, for th ...
DOI:
10.1002/etc.5027

10. Glucose regulation of the paralogous glucose sensing receptors Rgt2 and Snf3 of the yeast Saccharomyces cerevisiae

Author:
Kim, Jeong-Ho; Rodriguez, Rebeca
Source:
Biochimica et biophysica acta 2021 v.1865 no.6 pp. 129881
ISSN:
0304-4165
Subject:
starvation,   etc   ; Saccharomyces cerevisiae; glucose; promoter regions; vacuoles; yeasts;     Show all 6 Subjects
Abstract:
... The yeast Saccharomyces cerevisiae senses extracellular glucose levels through the two paralogous glucose sensing receptors Rgt2 and Snf3, which appear to sense high and low levels of glucose, respectively.Western blotting and qRT-PCR were used to determine expression levels of the glucose sensing receptors.Rgt2 and Snf3 are expressed at different levels in response to different glucose concentrat ...
DOI:
10.1016/j.bbagen.2021.129881

11. Sorting nexin Mdm1/SNX14 regulates nucleolar dynamics at the NVJ after TORC1 inactivation

Author:
Sharmin, Tasnuva; Takuma, Tsuneyuki; Morshed, Shamsul; Ushimaru, Takashi
Source:
Biochemical and biophysical research communications 2021 v.552 pp. 1-8
ISSN:
0006-291X
Subject:
starvation,   etc   ; genes; humans; protein kinases; rapamycin; research; yeasts;     Show all 7 Subjects
Abstract:
... The degradation of nucleolar proteins – nucleophagy – is elicited by nutrient starvation or the inactivation of target of rapamycin complex 1 (TORC1) protein kinase in budding yeast. Prior to nucleophagy, nucleolar proteins migrate to the nucleus–vacuole junction (NVJ), where micronucleophagy occurs, whereas rDNA (rRNA gene) repeat regions are condensed and escape towards NVJ-distal sites. This su ...
DOI:
10.1016/j.bbrc.2021.03.033

12. Worker Size Diversity Has No Effect on Overwintering Success under Natural Conditions in the Ant Temnothorax nylanderi

Author:
Honorio, Romain; Doums, Claudie; Molet, Mathieu
Source:
Insects 2021 v.12 no.5
ISSN:
2075-4450
Subject:
starvation,   etc   ; Temnothorax; cold; mortality; overwintering; temperature; weight loss; winter;     Show all 8 Subjects
Abstract:
... Winter is a difficult period for animals that live in temperate zones. It can inflict high mortality or induce weight loss with potential consequences on performance during the growing season. Social groups include individuals of various ages and sizes. This diversity may improve the ability of groups to buffer winter disturbances such as starvation or cold temperature. Studies focusing on the buf ...
DOI:
10.3390/insects12050379

13. Mg deficiency interacts with the circadian clock and phytochromes pathways in Arabidopsis

Author:
Rivière, Quentin; Xiao, Qiying; Gutsch, Annelie; Defrance, Matthieu; Webb, Alex A. R.; Verbruggen, Nathalie
Source:
Annals of applied biology 2021 v.178 no.2 pp. 387-399
ISSN:
0003-4746
Subject:
starvation,   etc   ; Arabidopsis thaliana; circadian clocks; magnesium; phytochrome; transcriptomics;     Show all 6 Subjects
Abstract:
... Little is known about the relationship between nutrition and the circadian clock in plants. The first global transcriptomic study in plants of the response to magnesium deficiency (–Mg) revealed that the circadian clock was affected in the Arabidopsis thaliana model species. Interactions between the circadian clock and Mg status were here investigated in the light of recent knowledge. We highlight ...
DOI:
10.1111/aab.12659

14. Requirement of the exopolyphosphatase gene for cellular acclimation to phosphorus starvation in a cyanobacterium, Synechocystis sp. PCC 6803

Author:
Hiyoshi, Tatsunori; Oyanagi, Kenta; Niki, Takuma; Fujiwara, Shoko; Sato, Norihiro
Source:
Biochemical and biophysical research communications 2021 v.540 pp. 16-21
ISSN:
0006-291X
Subject:
starvation,   etc   ; acclimation; cell growth; exopolyphosphatase; metabolism; phosphates; phosphorus; regulon; research;     Show all 9 Subjects
Abstract:
... Polyphosphate, which is ubiquitous in cells in nature, is involved in a myriad of cellular functions, and has been recently focused on its metabolism related with microbial acclimation to phosphorus-source fluctuation. In view of the ecological importance of cyanobacteria as the primary producers, this study investigated the responsibility of polyphosphate metabolism for cellular acclimation to ph ...
DOI:
10.1016/j.bbrc.2020.12.095

15. Catalytic activity profile of polyP:AMP phosphotransferase from Myxococcus xanthus

Author:
Kimura, Yoshio; Kamatani, Shiori
Source:
Journal of bioscience and bioengineering 2021 v.131 no.2 pp. 147-152
ISSN:
1389-1723
Subject:
starvation,   etc   ; ; Myxococcus xanthus; adenylate kinase; catalytic activity; polyphosphate kinase; polyphosphates;     Show all 7 Subjects
Abstract:
... Myxococcus xanthus generates polyphosphates (polyPs) during starvation and forms fruiting bodies through the activity of polyphosphate kinase (Ppk). M. xanthus polyP:AMP phosphotransferase (Pap), a class II Ppk2, catalyzes the transfer of the terminal phosphate from polyP to AMP to yield ADP, but its enzymatic properties have not been investigated in detail. In this study, we found that Pap was ac ...
DOI:
10.1016/j.jbiosc.2020.09.016

16. Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo

Author:
Qian, Jing; Zhang, Liang; Wang, Jiemin; Teng, Zhidong; Cao, Ting; Zheng, Lei; Cao, Yuping; Qin, Wenwu; Liu, Yun; Guo, Huichen
Source:
Journal of hazardous materials 2021 v.401 pp. 123863
ISSN:
0304-3894
Subject:
starvation,   etc   ; cysteamine; diabetes; enzymes; fluorescent dyes; pantothenic acid; physiology;     Show all 7 Subjects
Abstract:
... Pantetheinase, also known as Vanin-1, catalyzes pantetheine to decompose into the precursor of CoA — pantothenic acid and aminothiol cysteamine. Studies have shown that Vanin-1 plays an important role in many important physiological pathologies. In this paper, a new red emission ratio fluorescent probe DCM-PA (I₆₄₀ ₙₘ/I₅₆₄ ₙₘ) has been implemented to detect the activity of Vanin-1 in cells and viv ...
DOI:
10.1016/j.jhazmat.2020.123863

17. Energy and sugar signaling during hypoxia

Author:
Cho, Hsing‐Yi; Loreti, Elena; Shih, Ming‐Che; Perata, Pierdomenico
Source:
Thenew phytologist 2021 v.229 no.1 pp. 57-63
ISSN:
0028-646X
Subject:
starvation,   etc   ; carbon; energy; hypoxia; metabolism; oxygen; regrowth; sugars; transcription (genetics);     Show all 9 Subjects
Abstract:
... The major consequence of hypoxia is a dramatic reduction in energy production. At the onset of hypoxia, both oxygen and ATP availability decrease. Oxygen and energy sensing therefore converge to induce an adaptive response at both the transcriptional and translational levels. Oxygen sensing results in stabilization of the transcription factors that activate hypoxia‐response genes, including enzyme ...
DOI:
10.1111/nph.16326

18. Induction of protein aggregation and starvation response by tRNA modification defects

Author:
Klassen, Roland; Bruch, Alexander; Schaffrath, Raffael
Source:
Current genetics 2020 v.66 no.6 pp. 1053-1057
ISSN:
0172-8083
Subject:
starvation,   etc   ; homeostasis; transcription (genetics); yeasts;     Show all 4 Subjects
Abstract:
... Posttranscriptional modifications of anticodon loops contribute to the decoding efficiency of tRNAs by supporting codon recognition and loop stability. Consistently, strong synthetic growth defects are observed in yeast strains simultaneously lacking distinct anticodon loop modifications. These phenotypes are accompanied by translational inefficiency of certain mRNAs and disturbed protein homeosta ...
DOI:
10.1007/s00294-020-01103-w

19. A self-accelerated biocatalyst for glucose-initiated tumor starvation and chemodynamic therapy

Author:
Deng, Fuan; Fan, Guiling; Yuan, Ping; Liu, Yibin; Huang, Chuyu; Zhao, Linping; Wang, Xin; Yu, Xiyong; Cheng, Hong; Li, Shiying
Source:
Chemical communications 2020 v.56 no.93 pp. 14633-14636
ISSN:
1364-548X
Subject:
starvation,   etc   ; biocatalysts; glucose; neoplasms; therapeutics;     Show all 5 Subjects
Abstract:
... A self-accelerated biocatalyst (Bio-Cat) was developed based on BSA and GOx crosslinked nanoproteins for glucose-initiated tumor starvation and chemodynamic therapy. Bio-Cat could catalyze the glucose to elevate the intracellular H₂O₂ level and accelerate the conversion of Fe³⁺/Fe²⁺, resulting in an effective starvation therapy and an accelerated Fenton reaction for chemodynamic therapy. ...
DOI:
10.1039/d0cc06483a

20. Rapid changes in the ATG5‐ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT)

Author:
Crowley, Emily; Leung, Euphemia; Reynisson, Jóhannes; Richardson, Alan
Source:
TheFEBS journal 2020 v.287 no.22 pp. 4917-4932
ISSN:
1742-464X
Subject:
starvation,   etc   ; autophagy; humans; luciferase; luminescence;     Show all 5 Subjects
Abstract:
... Autophagy plays a role in several human diseases, but each of the current methods to measure autophagy has significant drawbacks. ATG5 and ATG16L1 are regulators necessary for autophagy; therefore, drugs that inhibit the interaction of these proteins may be therapeutically useful. To evaluate the interaction of ATG5 and ATG16L1 in cells, their cDNAs were fused to the coding sequences of SmBIT and ...
DOI:
10.1111/febs.15275