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- Author:
- Di Lorenzo, Patricia M.
- Source:
- Nutrients 2021 v.13 no.2
- ISSN:
- 2072-6643
- Subject:
- brain stem, etc ; mammals; taste; Show all 3 Subjects
- Abstract:
- ... This review is a curated discussion of the relationship between the gustatory system and the perception of food beginning at the earliest stage of neural processing. A brief description of the idea of taste qualities and mammalian anatomy of the taste system is presented first, followed by an overview of theories of taste coding. The case is made that food is encoded by the several senses that it ...
- DOI:
- 10.3390/nu13020398
-
http://dx.doi.org/10.3390/nu13020398
- Author:
- Bremm, Melanie; Krastel, Theresa; Cappel, Claudia; Zimmermann, Olga; Pfeffermann, Lisa-Marie; Katzki, Verena; Bonig, Halvard; Schäfer, Richard; Rettinger, Eva; Merker, Michael; Bremm, Sebastian; Schaefer, Kirsten; Klingebiel, Thomas; Soerensen, Jan; Bader, Peter; Huenecke, Sabine
- Source:
- Journal of immunological methods 2021 v.492 pp. 112960
- ISSN:
- 0022-1759
- Subject:
- stem cells, etc ; B-lymphocytes; cytotoxicity; Show all 3 Subjects
- Abstract:
- ... Recently, new advances were made regarding the depletion of CD45RA⁺ naïve T cells from haploidentical grafts as they are suspected to be the most alloreactive.Within this project we investigated CD45RA-depletion from G-CSF mobilized PBSC by two different purification strategies according to GMP, specifically direct depletion of CD45RA⁺ cells (one-step approach), or CD34-positive selection followed ...
- DOI:
- 10.1016/j.jim.2021.112960
-
https://dx.doi.org/10.1016/j.jim.2021.112960
- Author:
- Parveen, Abidah; Huang, Ying; Fantoukh, Omer; Alhusban, Manal; Raman, Vijayasankar; Wang, Yan-Hong; Wang, Wei; Ali, Zulfiqar; Khan, Ikhlas A.
- Source:
- Natural product research 2021 v.35 no.3 pp. 369-376
- ISSN:
- 1478-6427
- Subject:
- stems, etc ; Tinospora crispa; diterpenoids; research; Show all 4 Subjects
- Abstract:
- ... A new rearranged clerodane diterpenoid, tinocrispide was isolated from the stems of Tinospora crispa along with thirteen known compounds including eight clerodane diterpenoids. Among the known compounds baenzigeride A, (6S, 9 R)-vomifoliol and steponine are being reported for the first time from T. crispa. Their structures were elucidated by 1 D and 2 D NMR and confirmed by HRESIMS. The ¹³C NMR da ...
- DOI:
- 10.1080/14786419.2019.1633648
-
http://dx.doi.org/10.1080/14786419.2019.1633648
- Author:
- Stiewert, Austin M.; Wooming, Brian; Archer, Gregory S.
- Source:
- Poultry science 2021 v.100 no.5 pp. 101053
- ISSN:
- 0032-5791
- Subject:
- brain stem, etc ; brooms; cervical dislocation; radiography; Show all 4 Subjects
- Abstract:
- ... On-farm euthanasia of poultry is a necessity for minimizing disease spread and removing sick or injured birds to maintain optimum animal welfare. There are numerous methods that are approved for euthanasia of poultry by organizations like the American Veterinary Medical Association; however, all approved methods are not easily carried out on-farm or as effective as one another. Therefore, the obje ...
- DOI:
- 10.1016/j.psj.2021.101053
-
https://dx.doi.org/10.1016/j.psj.2021.101053
- Author:
- Seo, Min-Soo; Lee, Byeonghyeon; Kang, Kyung-Ku; Sung, Soo-Eun; Choi, Joo-Hee; Lee, Si-Joon; Kim, Young-In; Jung, Young-Suk; Kim, Un-Kyung; Kim, Kil Soo
- Source:
- Veterinary sciences 2021 v.8 no.3
- ISSN:
- 2306-7381
- Subject:
- brain stem, etc ; animal models; histopathology; phenotype; Show all 4 Subjects
- Abstract:
- ... DBA/2 mice are a well-known animal model for hearing loss developed due to intrinsic properties of these animals. However, results on the phenotype of hearing loss in DBA/2 mice have been mainly reported at an early stage in mice aged ≤7 weeks. Instead, the present study evaluated the hearing ability at 5, 13, and 34 weeks of age using DBA/2korl mice. Auditory brainstem response test was performed ...
- DOI:
- 10.3390/vetsci8030049
-
http://dx.doi.org/10.3390/vetsci8030049
- Author:
- Sakamaki, Taro; Kao, Kevin S.; Nishi, Katsuyuki; Chen, James Y.; Sadaoka, Kay; Fujii, Momo; Takaori-Kondo, Akifumi; Weissman, Irving L.; Miyanishi, Masanori
- Source:
- Biochemical and biophysical research communications 2021 v.539 pp. 34-41
- ISSN:
- 0006-291X
- Subject:
- hematopoietic stem cells, etc ; hematopoiesis; longevity; mice; research; Show all 5 Subjects
- Abstract:
- ... Self-renewal and multipotency are essential functions of hematopoietic stem cells (HSCs). To maintain homeostatic hematopoiesis, functionally uniform HSCs have been thought to be an ideal cell-of-origin. Recent technological advances in the field have allowed us to analyze HSCs with single cell resolution and implicate that functional heterogeneity may exist even within the highly purified HSC com ...
- DOI:
- 10.1016/j.bbrc.2020.12.077
-
https://dx.doi.org/10.1016/j.bbrc.2020.12.077
- Author:
- Sozen, Berna; Demir, Necdet; Zernicka-Goetz, Magdalena
- Source:
- Developmental biology 2021 v.470 pp. 84-94
- ISSN:
- 0012-1606
- Subject:
- stem cells, etc ; ; ectoderm; gastrulation; mice; morphogenesis; mutants; Show all 7 Subjects
- Abstract:
- ... At implantation, the mouse embryo undergoes a critical transformation which requires the precise spatiotemporal control of signalling pathways necessary for morphogenesis and developmental progression. The role played by such signalling pathways during this transition are largely unexplored, due to the inaccessibility of the embryo during the implantation when it becomes engulfed by uterine tissue ...
- DOI:
- 10.1016/j.ydbio.2020.11.005
-
https://dx.doi.org/10.1016/j.ydbio.2020.11.005
- Author:
- Naganuma, Hidekazu; Miike, Koichiro; Ohmori, Tomoko; Tanigawa, Shunsuke; Ichikawa, Takumi; Yamane, Mariko; Eto, Masatoshi; Niwa, Hitoshi; Kobayashi, Akio; Nishinakamura, Ryuichi
- Source:
- Developmental biology 2021 v.470 pp. 62-73
- ISSN:
- 0012-1606
- Subject:
- stem cells, etc ; RNA; genes; kidneys; mice; organoids; Show all 6 Subjects
- Abstract:
- ... Recent advances in stem cell biology have enabled the generation of kidney organoids in vitro, and further maturation of these organoids is observed after experimental transplantation. However, the current organoids remain immature and their precise maturation stages are difficult to determine because of limited information on developmental stage-dependent gene expressions in the kidney in vivo. T ...
- DOI:
- 10.1016/j.ydbio.2020.11.002
-
https://dx.doi.org/10.1016/j.ydbio.2020.11.002
- Author:
- Möckel, Doreen; Groulx, Thomas; Faure, Paul A.
- Source:
- Journal of comparative physiology 2021 v.207 no.1 pp. 27-42
- ISSN:
- 0340-7594
- Subject:
- brain stem, etc ; Eptesicus fuscus; neonates; ultrasonics; Show all 4 Subjects
- Abstract:
- ... We studied the development of hearing in newborn pups of the big brown bat, Eptesicus fuscus. In the majority of pups, the opening of both outer auditory canals occurred on or before postnatal day (PND) 7, but in some, it extended to PND 11. Using repeated auditory brainstem response (ABR) recordings, we tracked the progressive development and maturation of auditory sensitivity in 22 E. fuscus pup ...
- DOI:
- 10.1007/s00359-020-01452-4
-
http://dx.doi.org/10.1007/s00359-020-01452-4
- Author:
- Mucignat-Caretta, Carla
- Source:
- Cell and tissue research 2021 v.383 no.1 pp. 525-533
- ISSN:
- 0302-766X
- Subject:
- brain stem, etc ; amygdala; hypothalamus; research; rodents; Show all 5 Subjects
- Abstract:
- ... In the rodent brain, the central processing of ecologically relevant chemical stimuli involves many different areas located at various levels within the neuraxis: the main and accessory olfactory bulbs, some nuclei in the amygdala, the hypothalamus, and brainstem. These areas allow the integration of the chemosensory stimuli with other sensory information and the selection of the appropriate neuro ...
- DOI:
- 10.1007/s00441-020-03383-7
-
http://dx.doi.org/10.1007/s00441-020-03383-7
- Author:
- Zonderland, Jip; Moroni, Lorenzo
- Source:
- Biomaterials 2021 v.268 pp. 120572
- ISSN:
- 0142-9612
- Subject:
- stem cells, etc ; biocompatible materials; biophysics; mechanotransduction; medicine; Show all 5 Subjects
- Abstract:
- ... Mechanobiology, translating mechanical signals into biological ones, greatly affects cellular behavior. Steering cellular behavior for cell-based regenerative medicine approaches requires a thorough understanding of the orchestrating molecular mechanisms, among which mechanotransducive ones are being more and more elucidated. Because of their wide use and highly mechanotransduction dependent diffe ...
- DOI:
- 10.1016/j.biomaterials.2020.120572
-
https://dx.doi.org/10.1016/j.biomaterials.2020.120572
- Author:
- Dray, Nicolas; Than‐Trong, Emmanuel; Bally‐Cuif, Laure
- Source:
- BioEssays 2021 v.43 no.3 pp. e2000228
- ISSN:
- 0265-9247
- Subject:
- adult stem cells; neural stem cells, etc ; Danio rerio; adults; asymmetry; brain; homeostasis; progeny; vertebrates; Show all 9 Subjects
- Abstract:
- ... Adult stem cell populations must coordinate their own maintenance with the generation of differentiated cell types to sustain organ physiology, in a spatially controlled manner and over long periods. Quantitative analyses of clonal dynamics have revealed that, in epithelia, homeostasis is achieved at the population rather than at the single stem cell level, suggesting that feedback mechanisms coor ...
- DOI:
- 10.1002/bies.202000228
-
http://dx.doi.org/10.1002/bies.202000228
- Author:
- Talley, Mary Jo; Nardini, Diana; Qin, Shenyue; Prada, Carlos E.; Ehrman, Lisa A.; Waclaw, Ronald R.
- Source:
- Developmental biology 2021 v.476 pp. 137-147
- ISSN:
- 0012-1606
- Subject:
- stem cells, etc ; alleles; brain; mice; oligodendroglia; transcription factors; Show all 6 Subjects
- Abstract:
- ... The MAPK pathway is a major growth signal that has been implicated during the development of progenitors, neurons, and glia in the embryonic brain. Here, we show that the MAPK pathway plays an important role in the generation of distinct cell types from progenitors in the ventral telencephalon. Our data reveal that phospho-p44/42 (called p-ERK1/2) and the ETS transcription factor Etv5, both downst ...
- DOI:
- 10.1016/j.ydbio.2021.03.019
-
https://dx.doi.org/10.1016/j.ydbio.2021.03.019
- Author:
- Ding, Yanyan; Liu, Zhenxin; Liu, Feng
- Source:
- Developmental biology 2021 v.475 pp. 156-164
- ISSN:
- 0012-1606
- Subject:
- hematopoietic stem cells, etc ; adults; blood; chromatin; epigenetics; hematopoiesis; transcription (genetics); Show all 7 Subjects
- Abstract:
- ... Hematopoietic stem cells (HSCs) are the foundation of adult hematopoiesis that produce all types of mature blood lineages. In vertebrates, HSC development is a stepwise process, coordinately regulated by chromatin architectures and a group of transcriptional and epigenetic regulators. A deeper understanding of the molecular mechanisms governing the generation, expansion, and function of HSCs holds ...
- DOI:
- 10.1016/j.ydbio.2021.03.003
-
https://dx.doi.org/10.1016/j.ydbio.2021.03.003
- Author:
- Gritti, Nicola; Oriola, David; Trivedi, Vikas
- Source:
- Developmental biology 2021 v.474 pp. 48-61
- ISSN:
- 0012-1606
- Subject:
- stem cells, etc ; Animalia; bioreactors; computer simulation; embryogenesis; embryology; organoids; Show all 7 Subjects
- Abstract:
- ... Pluripotent stem cells, in the recent years, have been demonstrated to mimic different aspects of metazoan embryonic development in vitro. This has led to the establishment of synthetic embryology: a field that makes use of in vitro stem cell models to investigate developmental processes that would be otherwise inaccessible in vivo. Currently, a plethora of engineering-inspired techniques, includi ...
- DOI:
- 10.1016/j.ydbio.2020.10.013
-
https://dx.doi.org/10.1016/j.ydbio.2020.10.013
- Author:
- Pelham-Webb, Bobbie; Polyzos, Alexander; Wojenski, Luke; Kloetgen, Andreas; Li, Jiexi; Di Giammartino, Dafne Campigli; Sakellaropoulos, Theodore; Tsirigos, Aristotelis; Core, Leighton; Apostolou, Effie
- Source:
- Molecular cell 2021 v.81 no.8 pp. 1732-1748.e8
- ISSN:
- 1097-2765
- Subject:
- stem cells, etc ; acetylation; chromatin; mice; mitosis; topology; transcription (genetics); Show all 7 Subjects
- Abstract:
- ... During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we characterized at a genome-wide scale the dynamic transcriptional and architectural resetting of mouse pluripotent stem cells (PSCs) upon mitotic exit. We captured distinct waves of transcriptional reactivation wit ...
- DOI:
- 10.1016/j.molcel.2021.02.032
-
http://dx.doi.org/10.1016/j.molcel.2021.02.032
- Author:
- Hu, Feng; Hu, Ya-Jie; Su, Bao-Jun; Wang, Ya-Qi; Liao, Hai-Bing; Liang, Dong
- Source:
- Phytochemistry letters 2021 v.42 pp. 18-23
- ISSN:
- 1874-3900
- Subject:
- stems, etc ; enantiomers; lignans; neuroglia; plant biochemistry; research; spectral analysis; Show all 7 Subjects
- Abstract:
- ... Three new pairs of lignan enantiomers (1a/1b‒3a/3b) and two pairs of known lignan enantiomers (4a/4b and 5a/5b) were isolated from the stems of Mappianthus iodoides. The structures of the enantiomers were elucidated by comprehensive spectroscopic analyses. Their absolute configurations were assigned by single-crystal X-ray diffraction analysis as well as comparison of the experimental and calculat ...
- DOI:
- 10.1016/j.phytol.2021.01.006
-
https://dx.doi.org/10.1016/j.phytol.2021.01.006
- Author:
- Ding, Xinyuan; Jiang, Yuan; Xue, Feng; Zhang, Yiping; Wang, Mingchang; Kang, Muyi; Xu, Hui
- Source:
- Trees 2021 v.35 no.2 pp. 637-648
- ISSN:
- 0931-1890
- Subject:
- stem elongation, etc ; Picea; climate change; phenology; temperature; China; Show all 6 Subjects
- Abstract:
- ... KEY MESSAGE: A fixed sequence existed in the timing of critical stages between apical and radial growth. Radial growth was highly correlated with apical growth during the onset stage but not during the peak or cessation stages. The temporal relationships between the apical and radial growth of conifers may vary with species and site, and the varied responses of growth to climate change have rarely ...
- DOI:
- 10.1007/s00468-020-02065-9
-
http://dx.doi.org/10.1007/s00468-020-02065-9
- Author:
- Oikonomakos, Ioannis; Weerasinghe Arachchige, Lahiru Chamara; Schedl, Andreas
- Source:
- Molecular and cellular endocrinology 2021 v.524 pp. 111172
- ISSN:
- 0303-7207
- Subject:
- stem cells, etc ; adrenal cortex; adults; endocrinology; homeostasis; humans; Show all 6 Subjects
- Abstract:
- ... The adrenal cortex is the main steroid producing organ of the human body. Studies on adrenal tissue renewal have been neglected for many years, but recent intensified research has seen tremendous progress in our understanding of the formation and homeostasis of this organ. However, cell turnover of the adrenal cortex appears to be complex and several cell populations have been identified that can ...
- DOI:
- 10.1016/j.mce.2021.111172
-
https://dx.doi.org/10.1016/j.mce.2021.111172
- Author:
- Lusis, Aldons J.
- Source:
- Cell 2021 v.184 no.5 pp. 1139-1141
- ISSN:
- 0092-8674
- Subject:
- stem cells, etc ; atherosclerosis; blood; cell proliferation; coronary disease; hematopoiesis; risk; Show all 7 Subjects
- Abstract:
- ... Clonal hematopoiesis, defined as the presence of expanded somatic blood cell clones, is associated with about a doubling in the risk of coronary heart disease in humans. Heyde and colleagues now provide evidence that clonal hematopoiesis results largely from increased stem cell proliferation, which is, in turn, stimulated by atherosclerosis. ...
- DOI:
- 10.1016/j.cell.2021.02.005
-
https://dx.doi.org/10.1016/j.cell.2021.02.005
