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1. Corticotropin Releasing Factor Receptors in breast cancer: Expression and activity in hormone-dependent growth in vitro

Author:
Koureta, Maria; Karaglani, Makrina; Panagopoulou, Maria; Balgkouranidou, Ioanna; Papadaki-Anastasopoulou, Artemis; Zarouchlioti, Christina; Dekavallas, Spyridon; Kolios, George; Lambropoulou, Maria; Baritaki, Stavroula; Chatzaki, Ekaterini
Source:
Peptides 2020 v.129 pp. 170316
ISSN:
0196-9781
Subject:
steroid hormone receptors; steroid hormones,   etc   ; biopsy; breast neoplasms; corticotropin; estradiol; gene expression regulation; genes; human cell lines; human diseases; methylation; models; neuropeptides; pathophysiology; stress response; transcription (genetics);     Show all 16 Subjects
Abstract:
... Corticotropin Releasing Factor (CRF) neuropeptides coordinate the stress response via two distinct membrane receptors (CRF-Rs). We have previously shown expression of both CRF-Rs in human breast cancer tissues. In the present study, we examined in vitro using the MCF-7 cell line model, the regulation of CRF-Rs expression and their signaling in hormone-dependent breast cancer growth. Our findings s ...
DOI:
10.1016/j.peptides.2020.170316

2. Gene-Specific Actions of Transcriptional Coregulators Facilitate Physiological Plasticity: Evidence for a Physiological Coregulator Code

Author:
Stallcup, Michael R.; Poulard, Coralie
Source:
Trends in biochemical sciences 2020 v.45 no.6 pp. 497-510
ISSN:
0968-0004
Subject:
steroid hormone receptors,   etc   ; genes; physiological response; physiological state; post-translational modification; transcription (genetics);     Show all 6 Subjects
Abstract:
... The actions of transcriptional coregulators are highly gene-specific, that is, each coregulator is required only for a subset of the genes regulated by a specific transcription factor. These coregulator-specific gene subsets often represent selected physiological responses among multiple pathways targeted by a transcription factor. Regulating the activity of a coregulator via post-translational mo ...
DOI:
10.1016/j.tibs.2020.02.006
PubMed:
32413325
PubMed Central:
PMC7230073

3. Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies

Author:
Niwa, Toshiro; Okamoto, Ayaka; Narita, Kanae; Toyota, Manami; Kato, Kyoko; Kobayashi, Kyoko; Sasaki, Shoko
Source:
Archives of biochemistry and biophysics 2020 v.682 pp. 108283
ISSN:
0003-9861
Subject:
steroid hormones,   etc   ; catalytic activity; cortisol; cytochrome P-450; humans; hydroxylation; liquid chromatography; progesterone; testosterone;     Show all 9 Subjects
Abstract:
... Hydroxylation activity at the 6β-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (CYP) 3A4, polymorphic CYP3A5, and fetal CYP3A7 were compared to understand the catalytic properties of the major forms of human CYP3A subfamily. Testosterone, progesterone, and cortisol 6β-hydroxylation activities of recombinant CYP3A4, CYP3A5, and CYP3A7 were determi ...
DOI:
10.1016/j.abb.2020.108283

4. Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland

Author:
Cai, Cheguo; Geng, Ajun; Wang, Mengran; Yang, Li; Yu, Qing Cissy; Zeng, Yi Arial
Source:
Developmental biology 2020 v.458 no.1 pp. 43-51
ISSN:
0012-1606
Subject:
steroid hormones,   etc   ; epithelial cells; estrogen receptors; growth factors; hormonal regulation; mammary glands;     Show all 6 Subjects
Abstract:
... The steroid hormones are instrumental for the growth of mammary epithelial cells. Our previous study indicates that hormones regulate the expression of Rspondin-1 (Rspo1). Yet, the regulatory mechanism remains unknown. In the current study, we identify Amphiregulin (Areg) as a novel upstream regulator of Rspo1 expression mediating the hormonal influence. In response to hormonal signaling, Areg ema ...
DOI:
10.1016/j.ydbio.2019.10.006

5. Theca cells can support bovine oocyte growth in vitro without the addition of steroid hormones

Author:
Yang, Yinghua; Kanno, Chihiro; Sakaguchi, Kenichiro; Katagiri, Seiji; Yanagawa, Yojiro; Nagano, Masashi
Source:
Theriogenology 2020 v.142 pp. 41-47
ISSN:
0093-691X
Subject:
steroid hormones,   etc   ; androstenedione; blastocyst; cattle; coculture; culture media; follicular development; metaphase; oocytes; sowing; steroidogenesis; viability;     Show all 12 Subjects
Abstract:
... Theca cells (TCs) are essential to folliculogenesis by contributing to steroidogenesis. However, the in vitro growth (IVG) of oocytes co-cultured with TCs has not yet been examined. In the present study, we investigated the feasibility of the IVG of bovine oocyte-cumulus-granulosa cell complexes (OCGCs) co-cultured with TCs and the developmental competence of co-cultured oocytes. OCGCs and TCs wer ...
DOI:
10.1016/j.theriogenology.2019.09.037

6. Cypermethrin exposure during perinatal period affects fetal development and impairs reproductive functions of F1 female rats

Author:
Singh, Dipty; Irani, Delna; Bhagat, Sharad; Vanage, Geeta
Source:
The Science of the total environment 2020 v.707 pp. 135945
ISSN:
0048-9697
Subject:
steroid hormone receptors; steroid hormones,   etc   ; adulthood; adverse effects; body weight; cypermethrin; diethylstilbestrol; epithelium; females; fetal development; germ cells; histology; hormonal regulation; litter size; luteinization; males; mechanism of action; perinatal period; periodicity; pregnancy; progeny; pyrethrins; rats; sexual maturity;     Show all 24 Subjects
Abstract:
... Cypermethrin (CYP) is a ubiquitously present synthetic pyrethroid insecticide. It has endocrine disrupting activities which may adversely affect reproductive development and functions of offspring if exposed during critical developmental period. The present study was undertaken to delineate the effects of CYP exposure in pregnant female rats during perinatal period on the sexual maturation, hormon ...
DOI:
10.1016/j.scitotenv.2019.135945

7. Hemodynamics of the umbilical artery and conceptus-related measurements in singleton and twin pregnancies in ewes

Author:
Vasquez-Hidalgo, Manuel Alexander; Perry, George A.; Vonnahme, Kimberly Ann
Source:
Reproductive Biology 2020 v.20 no.2 pp. 132-139
ISSN:
1642-431X
Subject:
steroid hormones,   etc   ; blood flow; blood plasma; conceptus; ewes; fetal development; fetus; hematocrit; pregnancy; progeny; progesterone; twins; ultrasonography; umbilical arteries;     Show all 14 Subjects
Abstract:
... In sheep, adequate physiological maternal adaptations to twin fetuses are key for their prenatal development. We hypothesized that there is a relationship between maternal circulating steroid hormone concentration, hematocrit, and patterns of conceptus growth and umbilical artery hemodynamics in twin vs singleton pregnancies. Ewes carrying singletons (n = 6) or twins (n = 7) were selected. Hematoc ...
DOI:
10.1016/j.repbio.2020.04.002

8. High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo

Author:
Zhu, Biran; He, Wei; Yang, Fan; Chen, Lianguo
Source:
Chemosphere 2020 v.244 pp. 125468
ISSN:
0045-6535
Subject:
steroid hormones,   etc   ; Danio rerio; biosynthesis; developmental toxicity; embryo (animal); fish larvae; lipid metabolism; lipids; molluscicides; niclosamide; schistosomiasis; transcriptomics;     Show all 12 Subjects
Abstract:
... Niclosamide (NIC) is the most widely used molluscicides for preventing the occurrence of schistosomiasis disease, and its residues can be found in various environmental samples. However, the toxicity mechanism of NIC during early developmental stage remains largely unknown. In the present study, zebrafish embryos were acutely exposed to NIC at an environmentally realistic concentration (0 and 40 μ ...
DOI:
10.1016/j.chemosphere.2019.125468

9. Modulation of the renin–angiotensin–aldosterone system by steroid hormones during the oestrous cycle in mares

Author:
Satué, Katy; Montesinos, Paloma; MuÑoz, Ana
Source:
Acta veterinaria Hungarica 2020 v.68 no.1 pp. 79-84
ISSN:
1588-2705
Subject:
steroid hormones,   etc   ; aldosterone; angiotensinogen; cortisol; estrogens; estrous cycle; mares; mineralocorticoid receptors; ovulation; preovulatory period; progesterone; renin; resorption; sodium; women;     Show all 15 Subjects
Abstract:
... In women and females of different species of laboratory animals, oestrogens stimulate the renin–angiotensin–aldosterone system (RAAS) by increasing tissue and circulating levels of angiotensinogen and renin during the preovulatory period. Progesterone and cortisol compete with aldosterone for mineralocorticoid receptors, which results in increased Na⁺ reabsorption during the postovulatory period. ...
DOI:
10.1556/004.2020.00011

10. Courtship vocalizations: A potential biomarker of adult exposure to endocrine disrupting compounds?

Author:
Mhaouty-Kodja, Sakina
Source:
Molecular and cellular endocrinology 2020 v.501 pp. 110664
ISSN:
0303-7207
Subject:
steroid hormones,   etc   ; adults; biomarkers; copulation; courtship; endocrine-disrupting chemicals; females; males; pheromones; rodents; sex hormones; signal transduction; ultrasonics; vocalization;     Show all 14 Subjects
Abstract:
... In rodents, male courtship is stimulated by pheromones emitted by the sexually receptive female. In response, the male produces ultrasonic vocalizations, which appear to play a role in female attraction and facilitate copulation. The present review summarizes the main findings on courtship vocalizations and their tight regulation by sex steroid hormones. It describes studies that address the effec ...
DOI:
10.1016/j.mce.2019.110664

11. Glyphosate-based herbicide induces hyperplastic ducts in the mammary gland of aging Wistar rats

Author:
Zanardi, María V.; Schimpf, Marlise Guerrero; Gastiazoro, María P.; Milesi, María M.; Muñoz-de-Toro, Mónica; Varayoud, Jorgelina; Durando, Milena
Source:
Molecular and cellular endocrinology 2020 v.501 pp. 110658
ISSN:
0303-7207
Subject:
steroid hormone receptors,   etc   ; adverse effects; blood serum; estradiol; females; glyphosate; long term effects; mammary glands; progesterone; pups; tissues;     Show all 11 Subjects
Abstract:
... Glyphosate-based herbicide (GBH) exposure is known to have adverse effects on endocrine-related tissues. Here, we aimed to determine whether early postnatal exposure to a GBH induces long-term effects on the rat mammary gland. Thus, female Wistar pups were injected with saline solution (Control) or GBH (2 mg glyphosate/kg/day) on postnatal days (PND) 1, 3, 5 and 7. At 20 months of age, mammary gla ...
DOI:
10.1016/j.mce.2019.110658

12. Metabotropic glutamate receptor subtype 5 (mGlu5) is necessary for estradiol mitigation of light-induced anxiety behavior in female rats

Author:
Miller, Christiana K.; Krentzel, Amanda A.; Patisaul, Heather B.; Meitzen, John
Source:
Physiology & behavior 2020 v.214 pp. 112770
ISSN:
0031-9384
Subject:
steroid hormones,   etc   ; adults; antagonists; anxiety; brain; dopamine; estradiol; females; glutamate receptors; locomotion; neurons; oils; ovariectomy; phenotype; white light;     Show all 15 Subjects
Abstract:
... Anxiety-related behaviors are influenced by steroid hormones such as 17β-estradiol and environmental stimuli such as acute stressors. For example, rats exhibit increased anxiety-related behaviors in the presence, but not the absence, of light. In females, estradiol potentially mitigates these effects. Experiments across behavioral paradigms and brain regions indicate that estradiol action can be m ...
DOI:
10.1016/j.physbeh.2019.112770
PubMed:
31830486
PubMed Central:
PMC7029786

13. Association of dioxin in maternal breast milk and salivary steroid hormone levels in preschool children: A five-year follow-up study of a Vietnam cohort

Author:
Sun, Xian Liang; Okamoto, Rie; Kido, Teruhiko; Honma, Seijiro; Manh, Ho Dung; Nguyen, Hoang Viet; Anh, Le Thai; Phuc, Hoang Duc; Oanh, Nguyen Thi Phuong; Maruzeni, Shoko; Nakagawa, Hideaki; Nakayama, Shoji F.; Nhu, Dang Duc; Tung, Dao Van; Tan, Ngo Thi Minh; Giang, Le Minh
Source:
Chemosphere 2020 v.241 pp. 124899
ISSN:
0045-6535
Subject:
steroid hormones,   etc   ; Vietnamese people; boys; breast milk; girls; polychlorinated dibenzodioxins; prasterone; preschool children; surveys; testosterone; United States; Vietnam;     Show all 12 Subjects
Abstract:
... Recent studies have found elevated dioxin levels inside some former US military air bases in Vietnam, known as hotspots. The aim of the present study was to evaluate the association of dioxin exposure and steroid hormone in preschool children in Vietnam. In 2010, 2011, 52 primiparae mother–infant pairs in the hotspot and 52 pairs in a non-exposure region were enrolled. For the final analysis, 26 v ...
DOI:
10.1016/j.chemosphere.2019.124899

14. Liquid chromatography-ion mobility spectrometry-mass spectrometry analysis of multiple classes of steroid hormone isomers in a mixture

Author:
Rister, Alana L.; Dodds, Eric D.
Source:
Journal of chromatography 2020 v.1137 pp. 121941
ISSN:
1570-0232
Subject:
steroid hormones,   etc   ; chemical species; environmental science; ionization; isomerization; isomers; liquid chromatography; mass spectrometry; monitoring; rapid methods; sports; steroids;     Show all 12 Subjects
Abstract:
... Methods for the analysis of steroids have long been of interest due to the multiple uses for such methods in medical applications, sports monitoring, and environmental science. The analysis of steroids involves inherent analytical hurdles due to their low biological concentrations, poor ionization efficiencies, and frequent occurrence of isomerism. One analytical technique that has been recently a ...
DOI:
10.1016/j.jchromb.2019.121941
PubMed:
31877426
PubMed Central:
PMC6960350

15. Saponins as modulators of nuclear receptors

Author:
Zhang, Tiehua; Zhong, Shuning; Li, Tiezhu; Zhang, Jie
Source:
Critical reviews in food science and nutrition 2020 v.60 no.1 pp. 94-107
ISSN:
1549-7852
Subject:
steroid hormone receptors,   etc   ; hormones; ligands; medicinal properties; metabolic diseases; metabolic syndrome; peroxisome proliferator-activated receptors; saponins; therapeutics;     Show all 9 Subjects
Abstract:
... As plant-derived natural products, saponins have been widely applied for the dietary modification of metabolic syndrome. However, the underlying mechanisms of their preventive and therapeutic effects are still largely unclear. Nuclear receptors have been identified as potential pharmaceutical targets for treating various types of metabolic disorders. With similar structure to endogenous hormones, ...
DOI:
10.1080/10408398.2018.1514580

16. Potential of enzymatic process as an innovative technology to remove anticancer drugs in wastewater

Author:
Pereira, Camila Senna; Kelbert, Maikon; Daronch, Naionara Ariete; Michels, Camila; de Oliveira, Débora; Soares, Hugo Moreira
Source:
Applied microbiology and biotechnology 2020 v.104 no.1 pp. 23-31
ISSN:
0175-7598
Subject:
steroid hormones,   etc   ; antibiotics; antineoplastic agents; carcinogenicity; cytotoxicity; enzymes; industrial wastewater; risk; surface water; teratogenicity; wastewater treatment; white-rot fungi;     Show all 12 Subjects
Abstract:
... Anticancer drugs are a class of pharmaceutical compounds that have been found in hospital, domestic, and industrial wastewaters and also in surface waters. They have been showing recalcitrance to conventional wastewater treatment technologies and present a potential risk to environment and human health, since they exhibit cytotoxic, teratogenic, and carcinogenic among other effects in higher organ ...
DOI:
10.1007/s00253-019-10229-y

17. Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility

Author:
Stavreva, Diana A.; Garcia, David A.; Fettweis, Gregory; Gudla, Prabhakar R.; Zaki, George F.; Soni, Vikas; McGowan, Andrew; Williams, Geneva; Huynh, Anh; Palangat, Murali; Schiltz, R. Louis; Johnson, Thomas A.; Presman, Diego M.; Ferguson, Matthew L.; Pegoraro, Gianluca; Upadhyaya, Arpita; Hager, Gordon L.
Source:
Molecular cell 2019 v.75 no.6 pp. 1161-1177.e11
ISSN:
1097-2765
Subject:
steroid hormones,   etc   ; RNA; genes; glucocorticoid receptors; glucocorticoids; transcription (genetics);     Show all 6 Subjects
Abstract:
... Genes are transcribed in a discontinuous pattern referred to as RNA bursting, but the mechanisms regulating this process are unclear. Although many physiological signals, including glucocorticoid hormones, are pulsatile, the effects of transient stimulation on bursting are unknown. Here we characterize RNA synthesis from single-copy glucocorticoid receptor (GR)-regulated transcription sites (TSs) ...
DOI:
10.1016/j.molcel.2019.06.042
PubMed:
31421980
PubMed Central:
PMC6754282

18. Changes in steroid hormone profile and tumour progression after genistein treatment of canine inflammatory mammary cancer xenotransplanted mice

Author:
Martín-Ruiz, A.; Peña, L.; González-Gil, A.; Silvan, G.; Caceres, S.; Illera, J.C.
Source:
Research in veterinary science 2020 v.131 pp. 87-91
ISSN:
0034-5288
Subject:
steroid hormones,   etc   ; androstenedione; antineoplastic activity; blood serum; carcinogenesis; dogs; estrogen receptors; estrogens; genistein; immunohistochemistry; ingestion; mammary neoplasms (animal); metastasis; mice; models; neoplasm progression; progesterone; testosterone; therapeutics;     Show all 19 Subjects
Abstract:
... Isoflavones, such as genistein, have been proposed to have beneficial effects on health, including preventive or therapeutic actions in carcinogenesis. Their structural similarity to oestrogens allows them to bind at the cellular level with oestrogen receptors. Therefore, this study attempted to determine the antitumoural effects of genistein administered in a canine inflammatory mammary cancer xe ...
DOI:
10.1016/j.rvsc.2020.04.013

19. Characterization of gonadal glucocorticoid-induced leucine zipper (GILZ) protein expression during sex change in the protogynous orange-spotted grouper, Epinephelus coioides

Author:
Kuo, Cham-En; Chen, Young-Mao
Source:
Comparative biochemistry and physiology 2020 v.242 pp. 110416
ISSN:
1096-4959
Subject:
steroid hormones,   etc   ; Epinephelus coioides; cortisol; genes; grouper; immunohistochemistry; leucine zipper; oocytes; protein synthesis; protogyny; sex hormones; sex reversal; spermatogonia; steroidogenesis; testes;     Show all 15 Subjects
Abstract:
... Steroid hormones have been proven as a key drive of sex change in sequentially hermaphroditic organisms. However, the upstream mechanism of sex steroid hormones regulation that affect sex change remain unknown. The main glucocorticoid in teleost fish is cortisol, which both regulates steroidogenesis and has antistress action. Thus, cortisol might be one of the prime factors in sex change. In this ...
DOI:
10.1016/j.cbpb.2020.110416

20. Effects of new generation progestins, including as mixtures and in combination with other classes of steroid hormones, on zebrafish early life stages

Author:
Schmid, Simon; Willi, Raffael Alois; Salgueiro-González, Noelia; Fent, Karl
Source:
The Science of the total environment 2020 v.709 pp. 136262
ISSN:
0048-9697
Subject:
steroid hormones,   etc   ; Danio rerio; acetates; ecotoxicology; edema; embryo (animal); estradiol; fish; gene expression regulation; genes; glucocorticoids; larvae; messenger RNA; muscles; progesterone; propionic acid; transcription (genetics); water pollution;     Show all 18 Subjects
Abstract:
... Fish are exposed to progestins and steroid mixtures in contaminated waters but the ecotoxicological implications are not sufficiently known. Here we analyze effects of the new generation progestin dienogest (DNG) followed by investigating effects of mixtures of new generation progestins containing DNG, cyproterone acetate and drospirenone and the hormone progesterone. Furthermore, effects of this ...
DOI:
10.1016/j.scitotenv.2019.136262