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... Evidence from in vitro and rodent studies suggests that organophosphate esters (OPEs) may disrupt sex steroid hormone homeostasis, but no human studies, to date, have examined the effects of in utero exposure to OPEs on offspring reproductive development. Anogenital distance (AGD) is a sensitive biomarker of fetal hormonal milieu and has been used to assess reproductive toxicity. We evaluated the ...
... To protect the wellbeing of research animals, certain non-invasive measures are in increasing need to facilitate an early diagnosis of health and toxicity. In this study, feces specimen was collected from adult zebrafish to profile the metabolome fingerprint. Variability in fecal metabolite composition was also distinguished as a result of aging, perfluorobutanesulfonate (PFBS) toxicant, and fecal ...
... A study was performed to evaluate the efficacy of shrimp shell meal derived natural astaxanthin (SSM), supplemented with its commercial variant on gonadal maturation and vitellogenin gene (Vtg.) expression in reproductively active adults of the high-value ornamental cichlid discus (Symphysodon aequifasciatus) reared under captivity. Four isonitrogenous (50% crude protein), isolipidic (9% ether ext ...
steroidhormones, etc ; asymmetric membranes; crosslinking; issues and policy; nanofibers; pollutants; Show all 6 Subjects
Abstract:
... This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors. This publication contains SEM images in the supporting information that appear to have been manipulated. After careful examination of the first author's SEM records, lab books and ...
Eduardo M. Belotti; Sofía C. Sacco; Antonela F. Stassi; Ulises S. Notaro; Emmanuel Angeli; Lucas Etchevers; Juan A. Chiaraviglio; Hugo H. Ortega; Natalia R. Salvetti
steroidhormones, etc ; Holstein; cows; follicular development; granulosa cells; immunohistochemistry; neoplasms; ultrasonography; Show all 8 Subjects
Abstract:
... The objective of this study was to describe a case of a granulosa cell tumour (GCT) of incipient formation and to characterize it by its immunohistochemical pattern and hormonal profile. The case presented corresponds to a 7‐year‐old Holstein cow without reproductive disorders. No alterations were observed at rectal palpation, neither in the ultrasonography nor in the hormonal profile. A GCT conco ...
steroidhormones, etc ; White Leghorn; biosynthesis; chemometrics; chickens; eggs; females; males; odors; Show all 9 Subjects
Abstract:
... It's a difficult task for researchers to identify the gender of chicken eggs by nondestructive approach in the early of incubation, which not only could reduce the cost of incubation, but also could improve the welfare of chicks. Therefore, SPME/GC-MS has been applied to investigate its potential as a nondestructive tool for characterizing the differences of odor between male and female chicken eg ...
steroidhormones, etc ; Caenorhabditis elegans; larvae; molting; protein kinases; starvation; sterols; transcription (genetics); Show all 8 Subjects
Abstract:
... Molting is a widespread feature in the development of many invertebrates, including nematodes and arthropods. In Caenorhabditis elegans, the highly conserved protein kinases NEKL-2/NEK8/9 and NEKL-3/NEK6/7 (NEKLs) promote molting through their involvement in the uptake and intracellular trafficking of epidermal cargos. We found that the relative requirements for NEKL-2 and NEKL-3 differed at diffe ...
steroidhormones, etc ; adrenal cortex; androgens; corticotropin; mice; phenotype; prolactin; sexual dimorphism; transcription factors; Show all 9 Subjects
Abstract:
... A large number of previous reports described an effect of the pituitary hormone prolactin (PRL) on steroid hormone production by the adrenal cortex. However, those studies remained anecdotal and were never converted into a conceptual and mechanistic framework, let alone being translated into clinical care. In the light of our recently published landmark study where we described PRL signalling as a ...
steroidhormones, etc ; alkylation agents; asparaginase; body weight; drugs; hospitals; mortality; neutropenia; sarcoma; toxicity; Show all 10 Subjects
Abstract:
... Lomustine (1‐[2‐chloroethyl]3‐cyclohexyl‐1‐nitrosurea, CCNU) is an oral alkylating agent in the nitrosourea subclass that can cause myelosuppression, with neutropenia being the main dose‐limiting toxicity. The aim of this study was to define the frequency of neutropenic events and to identify predisposing risk factors in tumour‐bearing dogs treated with CCNU. Dogs receiving CCNU for various malign ...
steroidhormones, etc ; Alzheimer disease; blood serum; cognition; hippocampus; hormone secretion; memory; mice; neurotransmitters; research; Show all 10 Subjects
Abstract:
... Occlusal disharmony has been reported to be affected not only by cytokine and steroid hormone secretion and sympathetic activation in peripheral organs, but also by neurotransmitter release in the central nervous system. However, little is known about whether occlusal disharmony can decrease cognitive ability. We hypothesized that hyperocclusion decreases cognition via Alzheimer's disease-associat ...
steroidhormones, etc ; Toxoplasma gondii; adults; central nervous system; cortisol; females; habitats; males; parasites; parasitology; testosterone; Show all 11 Subjects
Abstract:
... Toxoplasma gondii is a common parasite that infects warm-blooded animals and influences host physiology. T. gondii is known to target the host's central nervous system, affecting circulating levels of steroid hormones, fear-related behaviors, and health, although these effects appear to vary among host taxa. Here, we investigated the relationship between T. gondii infection and levels of plasma te ...
steroidhormones, etc ; androstenedione; animal models; body weight; corticosterone; exposure duration; females; pollution; prasterone; pregnenolone; rats; Show all 11 Subjects
Abstract:
... Polycyclic aromatic hydrocarbons (PAHs) have been shown to influence endogenous hormones levels in animal models, but little is known about the effects of their mixtures. For hormone measurements, hair analysis is a promising approach to provide information on long-term status of hormones. Herein we used hair analysis to assess the combined effects of 13 PAHs on steroid and thyroid hormones levels ...
steroidhormones, etc ; estrone; half life; lighting; oxidation; photocatalysis; photostability; pollutants; singlet oxygen; solar radiation; wavelengths; Show all 11 Subjects
Abstract:
... Given the crucial role of noble metals in promoting singlet oxygen (¹O₂) production, the feasibility of relying on cheaper and more abundant metals remains challenging. This work investigates the continuous-flow photocatalytic degradation of steroid hormone micropollutants, achieved with photocatalytic membranes based on noble-metal (Pd) and noble-metal-free (Zn, Mn, free-base) porphyrins. Under s ...
steroidhormones, etc ; Staphylococcus epidermidis; cell death; epinephrine; estradiol; humans; norepinephrine; phenotype; saprotrophs; skin (animal); starvation; Show all 11 Subjects
Abstract:
... Effects of the human hormones and human microbiota on the growth of symbiotrophic and saprotrophic bacteria are well-known. However, no information is available on the effects of hormones on formation and survival of persister cells. Persistence is a phenotype providing the survival of the population in the presence of biocidal doses of antibiotics. Hence, the aim of this work was to investigate i ...
Zhonghe Li; Xingai Gao; Ming Li; Qiuliang Yan; Nan Zhang; Boyang Yu; Bimi Zhang; Shuying Zhang; Mohamed H. Helal; Ola A. Abu Ali; Mohamed A. Nassan; Muhammad Abdul Qyyum; Saira Asif; Awais Bokhari
... Steroid hormones as a class of emerging organic pollutant and high concern, due to their potential risks for human and environmental. Accurate analytical methods of steroid hormones are necessary in quantifying and monitoring. Biosensor is a promising technique. In this study, though part of 3α-HSD DNA to construct a regulatory plasmid and with the EGFP reporter gene to generate a reporter plasmid ...
... Abnormal expression of CYP19A1, a gene related to steroid hormone synthesis, causes steroid hormone disruption and leads to abnormal ovulation in granulosa cells. However, the exact mechanism of CYP19A1 regulation is unclear. In this study, we confirmed the localization of CYP19A1 in goat ovarian tissues using immunohistochemistry. Subsequently, we investigated the effects of CYP19A1 on granulosa ...
steroidhormones, etc ; Channa maculata; DNA methylation; fish; males; promoter regions; sex reversal; spermatogenesis; testes; transcription factors; Show all 10 Subjects
Abstract:
... Dmrt1 is an important transcriptional regulator that plays critical role in male gonadogenesis, testicular differentiation and development. In this study, Dmrt1 was cloned from blotched snakehead (Channa maculata), which is designated as CmDmrt1. CmDmrt1 encoded a putative protein with 293 amino acids and presented an extremely conserved DM domain. It was nearly expressed in the gonads, and the ex ...
... The relationship between the maternal endocrine environment and late embryonic mortality (> 28 d of gestation) in cattle is poorly defined. A definitive rise and alterations in secretion patterns of prostaglandin F₂α (PGF₂α) concentration without luteal regression is a trademark of this period. The objective was to evaluate whether consecutively induced PGF₂α pulses would alter steroid hormone pro ...
steroidhormones, etc ; Delphinapterus leucas; blood serum; enzyme-linked immunosorbent assay; fins; males; sexual maturity; testosterone; Barents Sea; Show all 9 Subjects
Abstract:
... The results of a study of the reproductive system of male beluga whales (Delphinapterus leucas), in particular, an analysis of the content of serum testosterone in blood serum samples during the growth and development of animals, are presented. This study was conducted on male whales kept in semi-free conditions of an open-air marine enclosure complex in the Barents Sea. A total of nine belugas we ...
steroidhormones, etc ; animal reproduction; apoptosis; bioinformatics; epigenetics; estradiol; estrone; genes; hormone metabolism; luciferase; progesterone; protein synthesis; swine; Show all 13 Subjects
Abstract:
... Porcine 17-hydroxysteroid dehydrogenase type 14 (HSD17B14) and FSH reporter (FSHR) genes play important roles in the metabolism of steroid hormones and the apoptosis of ovarian granulosa cells (GCs). Our bioinformatics analyses and the dual luciferase reporter assays indicated that porcine miR-20b and miR-31 target the 3′-UTR region of HSD17B14 gene, and miR-31 also targets the 3′-UTR region of FS ...