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You searched for: Subject "steroid saponins" Remove constraint Subject: "steroid saponins"
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1. Eight undescribed steroidal saponins including an unprecedented 16, 26-epoxy-furostanol saponin from Solanum xanthocarpum and their cytotoxic activities

Author:
Zhen-Peng Xu; Yan Liu; Si-Yi Wang; Zi-Wei Li; Xiao-Mao Li; Dong-Xu Lu; Juan Pan; Hai-Xue Kuang; Bing-You Yang
Source:
Phytochemistry 2022 v.199 pp. 113171
ISSN:
0031-9422
Subject:
steroid saponins,   etc   ; Solanum virginianum; acid hydrolysis; cytotoxicity; humans; neoplasm cells; plant biochemistry; spectral analysis;     Show all 8 Subjects
Abstract:
... Eight undescribed steroidal saponins named solasaponins A-H were isolated from the fruits of Solanum xanthocarpum, including an unusual 16,26-epoxy-furostanol saponin, two furostanol saponins, three isospirostanol saponins, two pseudo-spirostanol saponins. The structures of all compounds were elucidated by extensive spectroscopic data analyses (1D, 2D NMR, and HRESIMS) combined with physico-chemic ...
DOI:
10.1016/j.phytochem.2022.113171

2. Steroidal saponin from Agave marmorata Roezl modulates inflammatory response by inhibiting NF-κB and AP-1

Author:
Jonathan Cortés A; Ernesto Sánchez-Mendoza; Alejandro Zamilpa; Manases González-Cortazar; Maribel Herrera-Ruiz; Julio Cesar Almanza-Pérez; Eli Terán-Cabanillas; Renaud Condé; Lenin Domínguez-Ramírez; Elizur Montiel Arcos; Jesús Enrique Jiménez-Ferrer
Source:
Natural product research 2022 v.36 no.4 pp. 1123-1128
ISSN:
1478-6427
Subject:
steroid saponins,   etc   ; Agave; bioinformatics; chemistry; immunomodulation; inflammation; macrophages; medicinal properties; phosphatidylinositol 3-kinase; research; Mexico;     Show all 11 Subjects
Abstract:
... Agave marmorata Roezl is an endemic succulent specie from the Oaxaca-Puebla area of Mexico. This plant is a medicinal recourse and contain a rich variety of saponins-type compounds with multiples biological effects. Some of them have been shown to be anticancer, antibacterial, or having anti-inflammatory and immunoregulation effects. This paper is the first scientific report to describe the pharma ...
DOI:
10.1080/14786419.2020.1855638

3. Steroidal saponin components and their cancer cell cytotoxicity from Paris rugosa

Author:
Ling-Ling Yu; Shan Wang; Jie Wang; Huan Yan; Wei Ni; Hai-Yang Liu
Source:
Phytochemistry 2022 v.204 pp. 113452
ISSN:
0031-9422
Subject:
steroid saponins,   etc   ; breasts; colon; cytotoxicity; epoxides; humans; leukemia; liver; lungs; neoplasm cells; phytochemicals; spectral analysis;     Show all 12 Subjects
Abstract:
... The chemical components and availability of Paris rugosa were investigated for the first time, using a UPLC–MS/MS-based molecular networking strategy and phytochemical research. Ultimately, eleven undescribed steroidal saponins, parisrugosides A–K, and ten known analogs were identified. Their structures were confirmed using comprehensive spectroscopic data and chemical methods. The aglycones of pa ...
DOI:
10.1016/j.phytochem.2022.113452

4. An accurate, cost-effective and simple colorimetric method for the quantification of total triterpenoid and steroidal saponins from plant materials

Author:
Maxime Le Bot; Juliette Thibault; Quentin Pottier; Séverine Boisard; David Guilet
Source:
Food chemistry 2022 v.383 pp. 132597
ISSN:
0308-8146
Subject:
steroid saponins,   etc   ; absorptivity; chromatography; colorimetry; cosmetics; cost effectiveness; drugs; food chemistry; markets; sulfuric acid; triterpenoid saponins;     Show all 11 Subjects
Abstract:
... Saponins are heterosides widely distributed in the plant kingdom. Their properties are used in many industrial sectors, such as food, cosmetics, agriculture, and pharmaceuticals, and their use is increasing due to the market trend to use natural ingredients. Although many techniques exist to quantify saponins (e.g., gravimetric, foaming, spectrophotometric or chromatographic), none of these allow ...
DOI:
10.1016/j.foodchem.2022.132597

5. In-depth exploration and comparison of chemical constituents from two Lilium species through offline two-dimensional liquid chromatography combined with multimode acquisition of high-resolution mass spectrometry

Author:
Xingdong Wu; Jinjun Hou; Zijia Zhang; Lingmin Chen; Hui Ni; Yong Qian; Wenyong Wu; Huali Long; Linlin Zhang; FeiFei Li; Min Lei; Yong Huang; Dean Guo; Wanying Wu
Source:
Journal of chromatography 2022 v.1670 pp. 462980
ISSN:
0021-9673
Subject:
steroid saponins,   etc   ; Lilium brownii; Lilium lancifolium; cultivars; data collection; herbal medicines; human health; mass spectrometry; secondary metabolites; sulfur; China;     Show all 11 Subjects
Abstract:
... Lilium lancifolium and Lilium brownii viridulum were two common cultivars of Lilium in China, which have been used as a source of food in ancient China, and as a traditional herbal medicine in most northern hemispheres countries continues today. However, only a few secondary metabolites in Lilium closely related to human health have been reported. In this research, an offline two-dimensional (HILI ...
DOI:
10.1016/j.chroma.2022.462980

6. Spirostane saponins with a rearranged A/B ring system isolated from the rhizomes of Ophiopogon japonicus

Author:
Bo Liu; Bingxin Li; Gang Chen; Yingni Pan; Di Zhou; Ning Li
Source:
Phytochemistry 2022 v.193 pp. 112975
ISSN:
0031-9422
Subject:
steroid saponins,   etc   ; Ophiopogon japonicus; apoptosis; biosynthesis; cell lines; cytotoxicity; ethanol; humans; lung neoplasms; medicinal plants; nuclear magnetic resonance spectroscopy; plant biochemistry;     Show all 12 Subjects
Abstract:
... In this study, the popular food and medicinal herb Ophiopogon japonicus was investigated alongside a 70% ethanol extract of its rhizomes, revealing twenty-three steroidal glycosides with four undescribed steroidal saponins, named ophiopogonols A–D. Among them, ophiopogonols A–B are two unusual spirostanols with a rearranged A/B ring system (5/7/6/5/5/6 ring system) that have not previously been id ...
DOI:
10.1016/j.phytochem.2021.112975

7. Microencapsulation of steroidal saponins from agave sap concentrate using different carriers in spray drying

Author:
Benjamín Vázquez-Rodríguez; Janet A. Gutiérrez-Uribe; Daniel Guajardo-Flores; Liliana Santos-Zea
Source:
Food science and technology international 2022 v.28 no.7 pp. 622-633
ISSN:
1532-1738
Subject:
steroid saponins,   etc   ; bulk density; electron microscopy; food science; guar gum; hygroscopicity; maltodextrins; methylcellulose; microencapsulation; sap; solubility; stickiness; temperature; water content; xanthan gum;     Show all 15 Subjects
Abstract:
... Concentrated agave sap is a product with in vivo proven hypocholesterolemic and hypoglycemic activities, as well as in vitro anticancer potential. In the present work, a factorial design was used to determine the suitable drying conditions of concentrated agave by studying the effect of inlet temperature (150 °C, 180 °C and 210 °C) and the type of carrier agent (maltodextrin, hydroxypropyl methylc ...
DOI:
10.1177/10820132211049949

8. Advances in steroidal saponins biosynthesis

Author:
Yiyang Chen; Junkai Wu; Dan Yu; Xiaowei Du
Source:
Planta 2021 v.254 no.5 pp. 91
ISSN:
0032-0935
Subject:
steroid saponins,   etc   ; biochemical pathways; biosynthesis;     Show all 3 Subjects
Abstract:
... MAIN CONCLUSION: This work reviews recent advances in the pathways and key enzymes of steroidal saponins biosynthesis and sets the foundation for the biotechnological production of these useful compounds through transformation of microorganisms. Steroidal saponins, due to their specific chemical structures and active effects, have long been important natural products and that are irreplaceable in ...
DOI:
10.1007/s00425-021-03732-y

9. Steroidal Saponins─New Sources to Develop Potato (Solanum tuberosum L.) Genotypes Resistant against Certain Phytophthora infestans Strains

Author:
Sebastian Baur; Nicole Bellé; Oliver Frank; Sebastian Wurzer; Stefan Alexander Pieczonka; Tobias Fromme; Remco Stam; Hans Hausladen; Thomas Hofmann; Ralph Hückelhoven; Corinna Dawid
Source:
Journal of agricultural and food chemistry 2022 v.70 no.24 pp. 7447-7459
ISSN:
1520-5118
Subject:
steroid saponins,   etc   ; Irish potato famine; Phytophthora infestans; Solanum tuberosum; cultivars; disease resistance; food chemistry; food security; glycoalkaloids; hemolysis; leaves; metabolomics; oxylipins; plant protection; potatoes;     Show all 15 Subjects
Abstract:
... Plant pathogens such as Phytophthora infestans that caused the Irish Potato Famine continue to threaten local and global food security. Genetic and chemical plant protection measures are often overcome by adaptation of pathogen population structures. Therefore, there is a constant demand for new, consumer- and environment-friendly plant protection strategies. Metabolic alterations induced by P. in ...
DOI:
10.1021/acs.jafc.2c02575

10. Govanoside B, a new steroidal saponin from rhizomes of Trillium govanianum

Author:
Prithvi Pal Singh; Patil Shivprasad Suresh; Prateek Singh Bora; Vinod Bhatt; Upendra Sharma
Source:
Natural product research 2021 v.36 no.1 pp. 37-45
ISSN:
1478-6427
Subject:
steroid saponins,   etc   ; Trillium; herbal medicines; research;     Show all 4 Subjects
Abstract:
... Trillium govanianum, commonly known as Nag Chhatri and Teen Patra, is a popular herbal supplement traditionally used for curing different inflammatory and sexual disorders, infection and wound healing. Steroidal saponins are considered as active components of this species. The present study demonstrated the isolation of nine steroidal saponins, including one new compound named as govanoside B (9) ...
DOI:
10.1080/14786419.2020.1761360

11. Unravelling the antifungal and antiprotozoal activities and LC-MS/MS quantification of steroidal saponins isolated from Panicum turgidum

Author:
Ahmed A. Zaki; Mohamed M. Y. Kaddah; Hamada S. Abulkhair; Ahmed Ashour
Source:
RSC advances 2022 v.12 no.5 pp. 2980-2991
ISSN:
2046-2069
Subject:
steroid saponins,   etc   ; Candida albicans; Leishmania donovani; Leishmania infantum; Panicum turgidum; Trypanosoma brucei; active ingredients; antileishmanial properties; liquid chromatography; oxidoreductases; promastigotes; quantitative analysis; sugars; tandem mass spectrometry;     Show all 14 Subjects
Abstract:
... Bioassay-guided investigation of Panicum turgidum extract resulted in the identification of seven steroidal saponins (Turgidosterones 1–7). They were evaluated for their in vitro antifungal, antileishmanial, and antitrypanosomal activities. Turgidosterone 6 was the most active antifungal against Candida albicans and Candida neoformans (IC₅₀ values of 2.84 and 1.08 μg mL⁻¹, respectively). Turgidost ...
DOI:
10.1039/d1ra08532h

12. Environmentally benign, ultrasonication assisted, sustainable valorization for commercially important nutraceutical-Daucosterol from the heartwood of invasive Prosopis juliflora (Sw.) DC

Author:
Bhanuvalli R. Shamprasad; Ramya Subramani; Shankar Subramaniam; Arvind Sivasubramanian
Source:
Sustainable chemistry and pharmacy 2022 v.29 pp. 100810
ISSN:
2352-5541
Subject:
steroid saponins,   etc   ; Prosopis juliflora; acid treatment; cell walls; dietary supplements; ethanol; experimental design; food preservatives; green chemistry; heartwood; invasive species; response surface methodology; solvents; temperature; ultrasonic treatment;     Show all 15 Subjects
Abstract:
... Steroidal saponins are amphiphilic glycosidic chemical constructs, which possess diverse biological activities, that are attributable to the structural variations in the aglycone part and in the carbohydrate part. Daucosterol, a steroidal saponin, is a nutraceutical possessing various pleiotropic effects such as food preservative, immunomodulatory, anticancer and hypoglycemic effects. Non-conventi ...
DOI:
10.1016/j.scp.2022.100810

13. Cytotoxic steroidal saponins from the roots and rhizomes of Maianthemum henryi

Author:
Xin Zhang; Jing Sun; Xiaofei Zhang; Shuo Zhang; Xuan Zhang; Xuanji Xue; Zengjun Guo
Source:
Natural product research 2021 v.35 no.11 pp. 1808-1815
ISSN:
1478-6427
Subject:
steroid saponins,   etc   ; Maianthemum; cytotoxicity; humans; neoplasms; research;     Show all 6 Subjects
Abstract:
... Henryiosides F and G (1 and 2), two new steroidal saponins along with two known analogues (3 and 4) were obtained from the roots and rhizomes of Maianthemum henryi. Their structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D-NMR, IR and HR-ESI-MS data analysis. Cytotoxic activity in human HepG2 and SW620 tumour cells were evaluated by the MTT method an ...
DOI:
10.1080/14786419.2019.1641812

14. New steroidal glycosides from the roots of Asparagus cochinchinensis

Author:
Xu Pang; Lin Gao; Bei Wang; Xiao-Juan Chen; Jie Zhang; Bao-Lin Guo; Bai-Ping Ma
Source:
Journal of Asian natural products research 2021 v.23 no.3 pp. 205-216
ISSN:
1477-2213
Subject:
steroid saponins,   etc   ; medicinal plants; phytochemicals; research; spectroscopy;     Show all 5 Subjects
Abstract:
... Steroidal saponins were the main active constituents of the traditional medicinal herb Asparagus cochinchinensis. A phytochemical investigation of A. cochinchinensis roots led to the isolation of nine new steroidal glycosides (1–9) and seven known analogues (10–16). Their structures were established by spectroscopic analyses as well as necessary chemical evidence. ...
DOI:
10.1080/10286020.2021.1873956

15. Discovery of potent immune-modulating molecule taccaoside A against cancers from structures-active relationships of natural steroidal saponins

Author:
Zhi Dai; Pei-Feng Zhu; Hui Liu; Xuan-Chen Li; Yan-Yan Zhu; Yang-Yang Liu; Xiao-Long Shi; Wei-Di Chen; Ya-Ping Liu; Yun-li Zhao; Li-Xing Zhao; Hai-Yang Liu; Xiao-Dong Luo
Source:
Phytomedicine 2022 v.104 pp. 154335
ISSN:
0944-7113
Subject:
steroid saponins,   etc   ; T-lymphocytes; antibodies; antineoplastic activity; breast neoplasms; cell viability; cytotoxicity; immunogenicity; immunomodulation; immunomodulators; immunotherapy; interleukin-12; interleukin-6; lung neoplasms; melanoma; models; trisaccharides; viability assays;     Show all 18 Subjects
Abstract:
... In recent years, the T-cell therapy and immune checkpoint inhibitors toward CTLA-4 and PD-1/PD-L1 axis antibody therapy have acquired encouraging success. However, most of patients were still not benefited with lots of troubles, such as low penetration of tissues/cells, strong immunogenicity and cytokine release syndrome, and long manufacturing process and expensive costs. By contrast, the immune- ...
DOI:
10.1016/j.phymed.2022.154335

16. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control

Author:
Yujie Zhong; Jiayu Liu; Dianjun Sun; Tianmin Guo; Yanpeng Yao; Xiaodong Xia; Chao Shi; Xiaoli Peng
Source:
Food & function 2022 v.13 no.6 pp. 3660-3673
ISSN:
2042-650X
Subject:
steroid saponins,   etc   ; antioxidant enzymes; apoptosis; blood glucose; caspase-9; diabetic nephropathy; electron transport chain; histology; inflammation; kidneys; metformin; mitochondria; mitophagy; oxidative stress; pancreas; protective effect; rats; renal function;     Show all 18 Subjects
Abstract:
... Dioscin is a steroidal saponin isolated from various kinds of vegetables and herbs and possesses various biological activities. In this study, the protective effect of dioscin on diabetic nephropathy (DN) was explored. Dioscin and metformin (positive control) were administered orally to diabetic rats daily for 8 weeks. The biochemistry parameters, pancreas and kidney histological changes, oxidativ ...
DOI:
10.1039/d1fo02733f

17. Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandra thibetica

Author:
Wen-Tao Gao; Ling-Ling Yu; Jing Xie; Long-Gao Xiao; Shi-Juan Zhang; Wen-Yi Ma; Huan Yan; Hai-Yang Liu
Source:
Natural products and bioprospecting 2022 v.12 no.1 pp. 17
ISSN:
2192-2195
Subject:
steroid saponins,   etc   ; desmosides; phytochemicals; platelet aggregation; spectral analysis;     Show all 5 Subjects
Abstract:
... Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides, named ypsilandrosides U-X (1–4), and one new cholestanol glycoside, named ypsilandroside Y (5). Their structures have been established by extensive spectroscopic data and chemical methods. Among them, compound 4 is a rare spirostanol glycoside which possesses a novel 5(6 → 7) abeo-st ...
DOI:
10.1007/s13659-022-00337-0

18. Identification of active compounds in Ophiopogonis Radix from different geographical origins by UPLC-Q/TOF-MS combined with GC-MS approaches

Author:
Xiaoyu Zha; Gaowen Li; Ling Zhang; Qun Chen; Qing Xia
Source:
Open life sciences 2022 v.17 no.1 pp. 865-880
ISSN:
2391-5412
Subject:
steroid saponins,   etc   ; Ophiopogon japonicus; biosynthesis; cadaverine; chlorogenic acid; cysteine; cytidine; ethanolamine; galactose; gamma-aminobutyric acid; glutinone; glycerophospholipids; isoleucine; leucine; methionine; multivariate analysis; pelargonidin; proline; pyridoxine; serine; starch; sucrose; valine; China;     Show all 24 Subjects
Abstract:
... Ophiopogonis Radix, also known as Maidong in Chinese, is largely produced in the Sichuan and Zhejiang provinces: “Chuan-maidong (CMD)” and “Zhe-maidong (ZMD),” respectively. This study aimed to distinguish and evaluate the quality of CMD and ZMD. In this study, the tubers of CMD and ZMD were investigated using UPLC-Q/TOF-MS, GC-MS, and LC-MS methods, respectively. Overall, steroidal saponins, homo ...
DOI:
10.1515/biol-2022-0096

19. Structural characterization of three cytotoxic steroidal saponins from the leaves of Agave desmetiana hort.

Author:
Nagwan M. Gabr; Neveen S. Ghaly; Suzan A. Mina
Source:
Phytochemistry 2022 v.195 pp. 113057
ISSN:
0031-9422
Subject:
steroid saponins,   etc   ; Agave; cytotoxicity; human cell lines; plant biochemistry;     Show all 5 Subjects
Abstract:
... Three steroidal saponins detected by LC-MS were isolated from the leaves of Agave desmetiana hort. The three saponins were characterized as; Tigogenin 3 – [{O – β – D - xylopyranosyl (1 → 2) – α – L–rhamnopyranosyl (1 → 3)}–β–D– glucopyranoside), Tigogenin– 3 - ([O- α –L–rhamnopyranosyl (1 → 3) – β – D - glalactopyranosyl (1 → 2)] – β – D – glucopyranoside) and Tigogenin– 3 - ([{O – α – L – rhamno ...
DOI:
10.1016/j.phytochem.2021.113057

20. Five new steroidal saponins from the seeds of Solanum melongena L.

Author:
Fang-Fang Chen; Jing Zhou; Yu-Wei Zhang; Ya-Ping Chen; Yin-Ru Wang; Yun-Fang Zhao; Wei Liu; Xue-Feng Huang
Source:
Phytochemistry letters 2021 v.41 pp. 21-26
ISSN:
1874-3900
Subject:
steroid saponins,   etc   ; Solanum melongena; plant biochemistry; seeds; spectral analysis;     Show all 5 Subjects
Abstract:
... Two novel cholestane-type steroidal saponins, melongoside R-S (1-2) and three novel furostanol-type steroidal saponins, melongoside T-V (3-5), together with three known steroidal saponins (6-8) were isolated from the seeds of Solanum melongna L. The structures of these compounds were elucidated by extensive spectroscopic analysis such as HR-ESI-MS, ESI-MS and NMR. ...
DOI:
10.1016/j.phytol.2020.10.008