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steroidsaponins, etc ; Solanum virginianum; acid hydrolysis; cytotoxicity; humans; neoplasm cells; plant biochemistry; spectral analysis; Show all 8 Subjects
Abstract:
... Eight undescribed steroidal saponins named solasaponins A-H were isolated from the fruits of Solanum xanthocarpum, including an unusual 16,26-epoxy-furostanol saponin, two furostanol saponins, three isospirostanol saponins, two pseudo-spirostanol saponins. The structures of all compounds were elucidated by extensive spectroscopic data analyses (1D, 2D NMR, and HRESIMS) combined with physico-chemic ...
steroidsaponins, etc ; Agave; bioinformatics; chemistry; immunomodulation; inflammation; macrophages; medicinal properties; phosphatidylinositol 3-kinase; research; Mexico; Show all 11 Subjects
Abstract:
... Agave marmorata Roezl is an endemic succulent specie from the Oaxaca-Puebla area of Mexico. This plant is a medicinal recourse and contain a rich variety of saponins-type compounds with multiples biological effects. Some of them have been shown to be anticancer, antibacterial, or having anti-inflammatory and immunoregulation effects. This paper is the first scientific report to describe the pharma ...
steroidsaponins, etc ; breasts; colon; cytotoxicity; epoxides; humans; leukemia; liver; lungs; neoplasm cells; phytochemicals; spectral analysis; Show all 12 Subjects
Abstract:
... The chemical components and availability of Paris rugosa were investigated for the first time, using a UPLC–MS/MS-based molecular networking strategy and phytochemical research. Ultimately, eleven undescribed steroidal saponins, parisrugosides A–K, and ten known analogs were identified. Their structures were confirmed using comprehensive spectroscopic data and chemical methods. The aglycones of pa ...
... Saponins are heterosides widely distributed in the plant kingdom. Their properties are used in many industrial sectors, such as food, cosmetics, agriculture, and pharmaceuticals, and their use is increasing due to the market trend to use natural ingredients. Although many techniques exist to quantify saponins (e.g., gravimetric, foaming, spectrophotometric or chromatographic), none of these allow ...
steroidsaponins, etc ; Lilium brownii; Lilium lancifolium; cultivars; data collection; herbal medicines; human health; mass spectrometry; secondary metabolites; sulfur; China; Show all 11 Subjects
Abstract:
... Lilium lancifolium and Lilium brownii viridulum were two common cultivars of Lilium in China, which have been used as a source of food in ancient China, and as a traditional herbal medicine in most northern hemispheres countries continues today. However, only a few secondary metabolites in Lilium closely related to human health have been reported. In this research, an offline two-dimensional (HILI ...
steroidsaponins, etc ; Ophiopogon japonicus; apoptosis; biosynthesis; cell lines; cytotoxicity; ethanol; humans; lung neoplasms; medicinal plants; nuclear magnetic resonance spectroscopy; plant biochemistry; Show all 12 Subjects
Abstract:
... In this study, the popular food and medicinal herb Ophiopogon japonicus was investigated alongside a 70% ethanol extract of its rhizomes, revealing twenty-three steroidal glycosides with four undescribed steroidal saponins, named ophiopogonols A–D. Among them, ophiopogonols A–B are two unusual spirostanols with a rearranged A/B ring system (5/7/6/5/5/6 ring system) that have not previously been id ...
steroidsaponins, etc ; bulk density; electron microscopy; food science; guar gum; hygroscopicity; maltodextrins; methylcellulose; microencapsulation; sap; solubility; stickiness; temperature; water content; xanthan gum; Show all 15 Subjects
Abstract:
... Concentrated agave sap is a product with in vivo proven hypocholesterolemic and hypoglycemic activities, as well as in vitro anticancer potential. In the present work, a factorial design was used to determine the suitable drying conditions of concentrated agave by studying the effect of inlet temperature (150 °C, 180 °C and 210 °C) and the type of carrier agent (maltodextrin, hydroxypropyl methylc ...
steroidsaponins, etc ; biochemical pathways; biosynthesis; Show all 3 Subjects
Abstract:
... MAIN CONCLUSION: This work reviews recent advances in the pathways and key enzymes of steroidal saponins biosynthesis and sets the foundation for the biotechnological production of these useful compounds through transformation of microorganisms. Steroidal saponins, due to their specific chemical structures and active effects, have long been important natural products and that are irreplaceable in ...
Sebastian Baur; Nicole Bellé; Oliver Frank; Sebastian Wurzer; Stefan Alexander Pieczonka; Tobias Fromme; Remco Stam; Hans Hausladen; Thomas Hofmann; Ralph Hückelhoven; Corinna Dawid
... Plant pathogens such as Phytophthora infestans that caused the Irish Potato Famine continue to threaten local and global food security. Genetic and chemical plant protection measures are often overcome by adaptation of pathogen population structures. Therefore, there is a constant demand for new, consumer- and environment-friendly plant protection strategies. Metabolic alterations induced by P. in ...
steroidsaponins, etc ; Trillium; herbal medicines; research; Show all 4 Subjects
Abstract:
... Trillium govanianum, commonly known as Nag Chhatri and Teen Patra, is a popular herbal supplement traditionally used for curing different inflammatory and sexual disorders, infection and wound healing. Steroidal saponins are considered as active components of this species. The present study demonstrated the isolation of nine steroidal saponins, including one new compound named as govanoside B (9) ...
steroidsaponins, etc ; Candida albicans; Leishmania donovani; Leishmania infantum; Panicum turgidum; Trypanosoma brucei; active ingredients; antileishmanial properties; liquid chromatography; oxidoreductases; promastigotes; quantitative analysis; sugars; tandem mass spectrometry; Show all 14 Subjects
Abstract:
... Bioassay-guided investigation of Panicum turgidum extract resulted in the identification of seven steroidal saponins (Turgidosterones 1–7). They were evaluated for their in vitro antifungal, antileishmanial, and antitrypanosomal activities. Turgidosterone 6 was the most active antifungal against Candida albicans and Candida neoformans (IC₅₀ values of 2.84 and 1.08 μg mL⁻¹, respectively). Turgidost ...
... Steroidal saponins are amphiphilic glycosidic chemical constructs, which possess diverse biological activities, that are attributable to the structural variations in the aglycone part and in the carbohydrate part. Daucosterol, a steroidal saponin, is a nutraceutical possessing various pleiotropic effects such as food preservative, immunomodulatory, anticancer and hypoglycemic effects. Non-conventi ...
steroidsaponins, etc ; Maianthemum; cytotoxicity; humans; neoplasms; research; Show all 6 Subjects
Abstract:
... Henryiosides F and G (1 and 2), two new steroidal saponins along with two known analogues (3 and 4) were obtained from the roots and rhizomes of Maianthemum henryi. Their structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D-NMR, IR and HR-ESI-MS data analysis. Cytotoxic activity in human HepG2 and SW620 tumour cells were evaluated by the MTT method an ...
steroidsaponins, etc ; medicinal plants; phytochemicals; research; spectroscopy; Show all 5 Subjects
Abstract:
... Steroidal saponins were the main active constituents of the traditional medicinal herb Asparagus cochinchinensis. A phytochemical investigation of A. cochinchinensis roots led to the isolation of nine new steroidal glycosides (1–9) and seven known analogues (10–16). Their structures were established by spectroscopic analyses as well as necessary chemical evidence. ...
steroidsaponins, etc ; T-lymphocytes; antibodies; antineoplastic activity; breast neoplasms; cell viability; cytotoxicity; immunogenicity; immunomodulation; immunomodulators; immunotherapy; interleukin-12; interleukin-6; lung neoplasms; melanoma; models; trisaccharides; viability assays; Show all 18 Subjects
Abstract:
... In recent years, the T-cell therapy and immune checkpoint inhibitors toward CTLA-4 and PD-1/PD-L1 axis antibody therapy have acquired encouraging success. However, most of patients were still not benefited with lots of troubles, such as low penetration of tissues/cells, strong immunogenicity and cytokine release syndrome, and long manufacturing process and expensive costs. By contrast, the immune- ...
steroidsaponins, etc ; antioxidant enzymes; apoptosis; blood glucose; caspase-9; diabetic nephropathy; electron transport chain; histology; inflammation; kidneys; metformin; mitochondria; mitophagy; oxidative stress; pancreas; protective effect; rats; renal function; Show all 18 Subjects
Abstract:
... Dioscin is a steroidal saponin isolated from various kinds of vegetables and herbs and possesses various biological activities. In this study, the protective effect of dioscin on diabetic nephropathy (DN) was explored. Dioscin and metformin (positive control) were administered orally to diabetic rats daily for 8 weeks. The biochemistry parameters, pancreas and kidney histological changes, oxidativ ...
steroidsaponins, etc ; desmosides; phytochemicals; platelet aggregation; spectral analysis; Show all 5 Subjects
Abstract:
... Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides, named ypsilandrosides U-X (1–4), and one new cholestanol glycoside, named ypsilandroside Y (5). Their structures have been established by extensive spectroscopic data and chemical methods. Among them, compound 4 is a rare spirostanol glycoside which possesses a novel 5(6 → 7) abeo-st ...
... Ophiopogonis Radix, also known as Maidong in Chinese, is largely produced in the Sichuan and Zhejiang provinces: “Chuan-maidong (CMD)” and “Zhe-maidong (ZMD),” respectively. This study aimed to distinguish and evaluate the quality of CMD and ZMD. In this study, the tubers of CMD and ZMD were investigated using UPLC-Q/TOF-MS, GC-MS, and LC-MS methods, respectively. Overall, steroidal saponins, homo ...
steroidsaponins, etc ; Solanum melongena; plant biochemistry; seeds; spectral analysis; Show all 5 Subjects
Abstract:
... Two novel cholestane-type steroidal saponins, melongoside R-S (1-2) and three novel furostanol-type steroidal saponins, melongoside T-V (3-5), together with three known steroidal saponins (6-8) were isolated from the seeds of Solanum melongna L. The structures of these compounds were elucidated by extensive spectroscopic analysis such as HR-ESI-MS, ESI-MS and NMR. ...