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1. New furospirostane steroidal saponins from the flowers of Lilium Asiatic hybrids

Author:
Thi, Nhan Nguyen; Lee, Yeong-Geun; Seo, Kyeong-Hwa; Kim, Hyoung-Geun; Lee, Dae Young; Baek, Nam-In
Source:
Carbohydrate research 2019 v.481 pp. 36-42
ISSN:
0008-6215
Subject:
steroid saponins,   etc   ; Lilium; chemical structure; chromatography; crossing; flowers; fractionation; hybrids; phytochemicals; silica; solvents; spectroscopy;     Show all 12 Subjects
Abstract:
... Lilium Asiatic hybrids (Lilium spp.) are produced by interspecific crosses of Sinomartagon species belonging to Liliaceae. To date, no phytochemical work appears to have been conducted on Lilium Asiatic hybrids. In the current work, solvent extraction, solvent fractionation, and repeated SiO2 and ODS column chromatography yielded three new steroidal saponins along with a known one, avenacoside A ( ...
DOI:
10.1016/j.carres.2019.06.003

2. Triterpenoids in Echinoderms: Fundamental Differences in Diversity and Biosynthetic Pathways

Author:
Claereboudt, Emily J. S.; Caulier, Guillaume; Decroo, Corentin; Colson, Emmanuel; Gerbaux, Pascal; Claereboudt, Michel R.; Schaller, Hubert; Flammang, Patrick; Deleu, Magali; Eeckhaut, Igor
Source:
Marine drugs 2019 v.17 no.6
ISSN:
1660-3397
Subject:
steroid saponins,   etc   ; Asteroidea; Crinoidea; Echinoidea; Holothuroidea; Ophiuroidea; aquatic invertebrates; biochemical pathways; biosynthesis; sterols; triterpenoids;     Show all 11 Subjects
Abstract:
... Echinoderms form a remarkable phylum of marine invertebrates that present specific chemical signatures unique in the animal kingdom. It is particularly the case for essential triterpenoids that evolved separately in each of the five echinoderm classes. Indeed, while most animals have Δ5-sterols, sea cucumbers (Holothuroidea) and sea stars (Asteroidea) also possess Δ7 and Δ9(11)-s ...
DOI:
10.3390/md17060352

3. Steroids from herbs of Reineckia carnea and their anticomplement activities

Author:
Xu, Xu; Wu, Bei; Zhan, Yanzhi; Huang, Wenping; Yang, Shilin; Wen, Quan; Feng, Yulin
Source:
Natural product research 2019 v.33 no.11 pp. 1570-1576
ISSN:
1478-6427
Subject:
steroid saponins,   etc   ; herbs; hydrolysis; nuclear magnetic resonance spectroscopy; pregnanes; spectral analysis;     Show all 6 Subjects
Abstract:
... A new polyhydroxylated pregnane, named lβ,2β,3β,4β,5β,6β-hexolhydroxy-pregn-16-en-20-one (1), along with nine known (2–10) steroidal saponins were isolated from the whole plant of Reineckia carnea. Structure elucidations of all compounds were established by interpretation of their NMR spectral data, HR-ESI-MS and comparing with literatures. In addition, these compounds were evaluated with anticomp ...
DOI:
10.1080/14786419.2017.1423309

4. Steroidal saponins from the rhizome of Polygonatum sibiricum

Author:
Tang, Cheng; Yu, Ya-Ming; Qi, Qing-Ling; Wu, Xiao-Dan; Wang, Jia; Tang, Sheng-An
Source:
Journal of Asian natural products research 2019 v.21 no.3 pp. 197-206
ISSN:
1477-2213
Subject:
steroid saponins,   etc   ; Polygonatum sibiricum; anti-inflammatory activity; chemical structure; rhizomes; spectroscopy;     Show all 6 Subjects
Abstract:
... Four new steroidal saponins, 3-O-β-D-glucopyranosyl(1→4)-β-D-fucopyranosyl -(25R)-spirost-5-en-3β,17α-diol (1), 3-O-β-D-glucopyranosyl(1→4)-β-D- fucopyranosyl-(25S)-spirost-5-en-3β,17α-diol (2), 3-O-β-D-glucopyranosyl(1→2) -β-D-glucopyranosyl(1→4)-β-D-fucopyranosyl-(25R)-spirost-5-en-3β,17α-diol (3), 3-O-β-D-glucopyranosyl(1→4)-β-D-fucopyranosyl-(25R/S)-spirost-5-en-3β,12β-diol (4), together with ...
DOI:
10.1080/10286020.2018.1478815

5. Preclinical evaluation of safety and potential of black hellebore extracts for cancer treatment

Author:
Felenda, Jennifer E.; Turek, Claudia; Mörbt, Nora; Herrick, Anja; Müller, Margit B.; Stintzing, Florian C.
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 105
ISSN:
1472-6882
Subject:
steroid saponins,   etc   ; Helleborus niger; alternative medicine; angiogenesis; cell lines; chemical constituents of plants; genotoxicity; human umbilical vein endothelial cells; mechanism of action; medicinal properties; mutagens; neoplasm cells; neoplasms;     Show all 13 Subjects
Abstract:
... BACKGROUND: The therapeutic use of Helleborus niger L. is manifold due to its specific phytochemical composition. Two compound groups, the ranunculin derivates including protoanemonin and the steroidal saponins, are also associated with toxicity (genotoxicity, disintegration of membrane structures). Therefore, in vitro investigations were performed on safety aspects of a Helleborus niger aqueous f ...
DOI:
10.1186/s12906-019-2517-5

6. Saponin-rich fraction from Agave sisalana: effect against malignant astrocytic cells and its chemical characterisation by ESI-MS/MS

Author:
de Oliveira, João Victor A.; Botura, Mariana B.; dos Santos, Jener D. G.; Argolo, Deivison S.; da Silva, Victor Diogenes A.; da Silva, Gisele D.; de Lima, Hélimar G.; Braz Filho, Raimundo; Vieira, Ivo Jose C.; Branco, Alexsandro; Batatinha, Maria José M.; Costa, Silvia L.
Source:
Natural product research 2019 v.33 no.12 pp. 1769-1772
ISSN:
1478-6427
Subject:
steroid saponins,   etc   ; Agave sisalana; cell viability; cytotoxicity; electrospray ionization mass spectrometry; glioma; humans; lysosomes; neoplasm cells; rats; sisal; tandem mass spectrometry; toxicity testing; vacuoles; wastes;     Show all 15 Subjects
Abstract:
... Astrocytic tumour cells derived from human (GL-15) and rat (C6) gliomas, as well as non-tumoural astrocytic cells, were exposed to the saponin-rich fraction (SF) from Agave sisalana waste and the cytotoxic effects were evaluated. Cytotoxicity assays revealed a reduction of cell viability that was more intensive in glioma than in non-tumoural cells. The SF induced morphological changes in C6 cells. ...
DOI:
10.1080/14786419.2018.1434633

7. Advances in the antitumor activities and mechanisms of action of steroidal saponins

Author:
ZHAO, Ya-Zheng; ZHANG, Yuan-Yuan; HAN, Han; FAN, Rui-Ping; HU, Yang; ZHONG, Liang; KOU, Jun-Ping; YU, Bo-Yang
Source:
Chinese journal of natural medicines 2018 v.16 no.10 pp. 732-748
ISSN:
1875-5364
Subject:
steroid saponins,   etc   ; Oriental traditional medicine; antineoplastic activity; apoptosis; autophagy; mechanism of action; neoplasms; signal transduction;     Show all 8 Subjects
Abstract:
... The steroidal saponins are one of the saponin types that exist in an unbound state and have various pharmacological activities, such as anticancer, anti-inflammatory, antiviral, antibacterial and nerves-calming properties. Cancer is a growing health problem worldwide. Significant progress has been made to understand the antitumor effects of steroidal saponins in recent years. According to reported ...
DOI:
10.1016/S1875-5364(18)30113-4

8. Anticancer effect of Polyphyllin Ι in colorectal cancer cells through ROS-dependent autophagy and G2/M arrest mechanisms

Author:
Yu, Si; Wang, Lijiao; Cao, Zhixing; Gong, Daoyin; Liang, Qianyi; Chen, Hanting; Fu, Huizhu; Wang, Wenwen; Tang, Xue; Xie, Zihao; He, Yang; Peng, Cheng; Li, Yuzhi
Source:
Natural product research 2018 v.32 no.12 pp. 1489-1492
ISSN:
1478-6427
Subject:
steroid saponins,   etc   ; Western blotting; antineoplastic activity; autophagy; cell cycle; colorectal neoplasms; flow cytometry; neoplasm cells;     Show all 8 Subjects
Abstract:
... Polyphyllin Ι is a steroidal saponin isolated from the rhizoma of Paris polyphylla. In the present study, we aimed to investigate the anticancer effects of polyphyllin Ι in colorectal cancer and to elucidate the potential underlying molecular mechanisms. Using, CCK8 assay, flow cytometry, laser confocal microscope analysis and western blot, the anticancer effects of the polyphyllin Ι were analysed ...
DOI:
10.1080/14786419.2017.1353512

9. A new steroidal saponin from Polygonatum sibiricum

Author:
Zhang, Hong-Yang; Hu, Wei-Cheng; Ma, Guo-Xu; Zhu, Nai-Liang; Sun, Xiao-Bo; Wu, Hai-Feng; Xu, Xu-Dong
Source:
Journal of Asian natural products research 2018 v.20 no.6 pp. 586-592
ISSN:
1477-2213
Subject:
steroid saponins,   etc   ; Polygonatum sibiricum; cytotoxicity; human cell lines; inhibitory concentration 50; spectral analysis;     Show all 6 Subjects
Abstract:
... A new furostan type steroidal saponin, kingianoside Z (1), along with four known compounds (2–5), was isolated from the ethanolic extract of Polygonatum sibiricum Delar. ex Redoute. Their structures were determined by spectroscopical method and by comparison with previously reported spectroscopic data. Compounds 3–5 showed significant cytotoxicity against HepG2 cell lines with IC₅₀ values of 14.2, ...
DOI:
10.1080/10286020.2017.1351436

10. The bioassay-guided isolation of antifungal saponins from Hosta plantaginea leaves

Author:
Wang, Meng-Yue; Peng, Ying; Peng, Chong-Sheng; Qu, Jiang-Yuan; Li, Xiao-Bo
Source:
Journal of Asian natural products research 2018 v.20 no.6 pp. 501-509
ISSN:
1477-2213
Subject:
steroid saponins,   etc   ; Candida albicans; Fusarium; Hosta plantaginea; antifungal properties; fractionation; leaves; minimum inhibitory concentration; ornamental plants;     Show all 9 Subjects
Abstract:
... Four new steroidal saponins hostaside Ⅰ (1), hostaside Ⅱ (2), hostaside Ⅲ (3), and hostaside Ⅳ (4), together with five known steroidal saponins (5–9), were isolated by the bioassay-guided fractionation from the leaves of Hosta plantaginea (Lam.) Aschers, a worldwide well-known ornamental plant. Hostasides Ⅰ and Ⅱ showed significant antifungal activities, and they could inhibit the growth of Candid ...
DOI:
10.1080/10286020.2017.1329304

11. Formation and stability of emulsions stabilised by Yucca saponin extract

Author:
Ralla, Theo; Salminen, Hanna; Tuosto, Jessica; Weiss, Jochen
Source:
International journal of food science & technology 2018 v.53 no.6 pp. 1381-1388
ISSN:
0950-5423
Subject:
steroid saponins,   etc   ; Yucca; beverage industry; droplet size; emulsifying properties; emulsions; ionic strength; pH; surfactants;     Show all 9 Subjects
Abstract:
... Yucca saponin extract containing steroidal saponins was examined for its interfacial and emulsifying properties. For this purpose, we produced oil‐in‐water emulsions and tested their stability against environmental stresses (pH, ionic strength, heating and freeze‐thawing). Yucca saponin extract was highly surface‐active and formed negatively charged submicron‐sized emulsions at low surfactant‐to‐o ...
DOI:
10.1111/ijfs.13715

12. Phytochemical and chemotaxonomic study on the rhizomes of Smilax riparia (Liliaceae)

Author:
Luo, Rui; Gao, Xiao-Li; Shi, Chang; Wei, Yu-Xi; Hou, Pi-Yong; Li, Hong-Gang; Wang, Shu-Qing; Anderson, Samantha; Zhang, Yan-Wen; Wu, Xiao-Hui
Source:
Biochemical systematics and ecology 2018 v.76 pp. 58-60
ISSN:
0305-1978
Subject:
steroid saponins,   etc   ; Liliaceae; Smilax riparia; carboxylic acids; chemical constituents of plants; chemotaxonomy; rhizomes; spectroscopy;     Show all 8 Subjects
Abstract:
... A phytochemical study on the rhizomes of Smilax riparia led to the isolation of 16 saponin compounds, including nine furostanol steroidal saponins (1–4, 6, 7, 10, 12, 14), six spirostanol steroidal saponins (5, 8, 9, 11, 13, 15) and one 20-carboxylic acid γ-lactone steroidal saponin (16). The structures of these compounds were identified by spectroscopic methods and comparison of their data with t ...
DOI:
10.1016/j.bse.2017.12.005

13. Novel steroidal saponins with cytotoxic activities from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl

Author:
Wu, Yan; Bi, Su-Xia; Huang, Zhen; Qi, Jin; Yu, Bo-Yang
Source:
RSC advances 2018 v.8 no.5 pp. 2498-2505
ISSN:
2046-2069
Subject:
steroid saponins,   etc   ; Ophiopogon japonicus; cell lines; cytotoxicity; nuclear magnetic resonance spectroscopy; roots; spectral analysis;     Show all 7 Subjects
Abstract:
... Six new steroidal saponins (1–6) and one known steroidal saponin (7) were obtained from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl. Their structures were determined by the detailed analysis of extensive nuclear magnetic resonance and mass spectroscopic data. The in vitro cytotoxic activities of these compounds against MDA-MB-435, HepG2 and A549 cell lines were also investigated. ...
DOI:
10.1039/c7ra12363a

14. Steroidal Saponin from Allium porrum

Author:
Gvazava, L.N.; Skhirtladze, A.V.
Source:
Chemistry of natural compounds 2017 v.53 no.6 pp. 1093-1095
ISSN:
0009-3130
Subject:
steroid saponins,   etc   ; Allium porrum; chemical structure; fractionation; spectral analysis;     Show all 5 Subjects
Abstract:
... A new steroidal glycoside (1) was isolated by fractionation of total extracted substances from Allium porrum. Its structure was determined as (25R)-5α-spirostan-3β,6β-diol-12-one 3-O-β-D-glucopyranosyl-(1→2)-[β-D-fucopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside using chemical transformations, physical constants, and spectral data. ...
DOI:
10.1007/s10600-017-2208-8

15. Phytochemical and chemotaxonomic studies on Dioscorea collettii

Author:
Jing, Song-Song; Wang, Ying; Li, Xue-Jiao; Li, Xia; Zhao, Wan-Shun; Zhou, Bin; Zhao, Cheng-Cheng; Huang, Lu-Qi; Gao, Wen-Yuan
Source:
Biochemical systematics and ecology 2017 v.71 pp. 10-15
ISSN:
0305-1978
Subject:
steroid saponins,   etc   ; Dioscorea; chemical structure; chemotaxonomy; flavonoids; phenols; spectroscopy; sterols;     Show all 8 Subjects
Abstract:
... A chemical investigation of Dioscorea collettii led to the isolation of twenty-nine compounds, including six steroid saponins (1–6), thirteen monocyclic phenols (7–19), two flavonoids (20–21), three sterols (22–24), and five cyclodipeptides (25–29). The chemical structures of these compounds were elucidated using spectroscopic methods and by comparing their data to that reported in the literature. ...
DOI:
10.1016/j.bse.2017.01.010

16. Steroidal saponins from the genus Allium

Author:
Sobolewska, Danuta; Michalska, Klaudia; Podolak, Irma; Grabowska, Karolina
Source:
Phytochemistry reviews 2016 v.15 no.1 pp. 1-35
ISSN:
1568-7767
Subject:
steroid saponins,   etc   ; Allium; chemistry; cytotoxicity; sulfur;     Show all 5 Subjects
Abstract:
... Steroidal saponins are widely distributed among monocots, including the Amaryllidaceae family to which the Allium genus is currently classified. Apart from sulfur compounds, these are important biologically active molecules that are considered to be responsible for the observed activity of Allium species, including antifungal, cytotoxic, enzyme-inhibitory, and other. In this paper, literature data ...
DOI:
10.1007/s11101-014-9381-1
PubMed:
26893594
PubMed Central:
PMC4735241

17. Two new steroidal saponins from the roots of Cynanchum limprichtii

Author:
Liu, Jia-Chuan; Yu, Li-Li; Tang, Ming-Xu; Lu, Xiao-Jie; Zhao, Dan; Wang, Hai-Feng; Chen, Gang; Su, Guang-Yue; Pei, Yue-Hu
Source:
Journal of Asian natural products research 2018 v.20 no.9 pp. 875-882
ISSN:
1477-2213
Subject:
steroid saponins,   etc   ; Cynanchum; cytotoxicity; human cell lines; humans; neoplasm cells; nuclear magnetic resonance spectroscopy; roots; spectral analysis;     Show all 9 Subjects
Abstract:
... As a part of our continuing research for bioactive constituents from Cynanchum limprichtii Schltr., two new C₂₁ steroidal glycosides limproside A (1) and limproside B (2) were isolated from the roots of Cynanchum limprichtii. Their structures were elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. The cytotoxicity of two compounds against two selected human ...
DOI:
10.1080/10286020.2017.1405939

18. A novel ultra high‐performance liquid chromatography‐tandem mass spectrometry method for the simultaneous determination of xanthones and steroidal saponins in crude and salt‐processed Anemarrhenae Rhizoma aqueous extracts

Author:
Ji, De; Su, Xiaonan; Huang, Ziyan; Wang, Qiaohan; Lu, Tulin
Source:
Journal of separation science 2018 v.41 no.11 pp. 2310-2320
ISSN:
1615-9306
Subject:
steroid saponins,   etc   ; acetonitrile; formic acid; ionization; monitoring; oral administration; pharmacokinetics; rats; tandem mass spectrometry; ultra-performance liquid chromatography; xanthones;     Show all 11 Subjects
Abstract:
... We established a rapid and sensitive ultra high‐performance liquid chromatography tandem mass spectrometry method for the simultaneous quantification of xanthones and steroidal saponins in rat plasma. Chromatographic separation was achieved on a C₁₈ column with a mobile phase comprising acetonitrile and 0.1% formic acid. The detection was performed by negative electrospray ionization in multiple r ...
DOI:
10.1002/jssc.201701408

19. Identification, characterization and expression analysis of genes involved in steroidal saponin biosynthesis in Dracaena cambodiana

Author:
Zhu, Jia-Hong; Li, Hui-Liang; Guo, Dong; Wang, Ying; Dai, Hao-Fu; Mei, Wen-Li; Peng, Shi-Qing
Source:
Journal of plant research 2018 v.131 no.3 pp. 555-562
ISSN:
0918-9440
Subject:
steroid saponins,   etc   ; Dracaena; biochemical pathways; biosynthesis; enzymes; gene expression regulation; genes; medicinal plants; open reading frames; stems; transcriptome; transcriptomics;     Show all 12 Subjects
Abstract:
... Dracaena cambodiana is a traditional medicinal plant used for producing dragon’s blood. The plants and dragon’s blood of D. cambodiana contain a rich variety of steroidal saponins. However, little is known about steroidal saponin biosynthesis and its regulation in D. cambodiana. Here, 122 genes encoding enzymes involved in steroidal saponin biosynthesis were identified based on transcriptome data, ...
DOI:
10.1007/s10265-017-1004-7

20. Histopathological changes in placenta and liver of pregnant rats administered with aqueous extract of Dioscorea hispida var. daemona (Roxb) Prain & Burkill

Author:
Muhammad, Hussin; Maslan, Shahira Fariza; Md Saad, Wan Mazlina; Thani, Nur Syimah Izzah Abdullah; Ibnu Rasid, Elda Nurafnie; Mahomoodally, Mohamad Fawzi; Awang, Norizah
Source:
Food and chemical toxicology 2019 v.131 pp. 110538
ISSN:
0278-6915
Subject:
steroid saponins,   etc   ; Dioscorea hispida; adverse effects; animal tissues; body weight; chemical constituents of plants; chromatin; cytolysis; eosin; fibrin; glycogen; hepatotoxicity; histology; histopathology; laboratory animals; liver; placenta; rats; staple foods; toxicology; tubers; yams; Malaysia;     Show all 23 Subjects
Abstract:
... Dioscorea hispida var. daemona (Roxb) Prain & Burkill (DH), also known a tropical yam or intoxicating yam is a bitter wild tuber which is consumed as a staple food and traditionally used as a remedy in Malaysia. However, DH is also notorious for its intoxicating effects and there is currently a dearth of study of possible effects of DH on liver and placental tissues and hence its safe consumption ...
DOI:
10.1016/j.fct.2019.05.046