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... Covalent organic frameworks (COFs), a class of flexibly tunable crystalline materials, have fascinating potential in photocatalytic hydrogen peroxide (H₂O₂) evolution under visible light irradiation. However, achieving efficient catalytic activity by tuning the composition of COFs and the linkages of building blocks is still a challenge. Herein, four imine-linked COFs with different numbers of hyd ...
... The study aimed to identify umami peptides from Boletus edulis and explore their umami mechanism. 421, 713 and 616 peptides identified by LC-MS/MS from control sample (CS), enzymatically extracted sample (EES) and high-pressure cooking sample (HPCS), respectively. According to molecular docking study, three potential umami peptides (DGF, KCGQ and HHYE) were chemically synthesized for sensory evalu ...
... Aflatoxins are strong carcinogenic and mutagenic fungal metabolites, and aflatoxin contamination is a critical issue in agriculture and food production. Natural flavonoids can suppress aflatoxin biosynthesis; however, the structure–activity relationship remains unclear. In the present study, a total of 36 structurally related natural flavonoids were tested against the aflatoxigenic Aspergillus fla ...
quantitative structure-activityrelationships, etc ; copper; electron paramagnetic resonance spectroscopy; electron transfer; graphene; humic acids; nanoparticles; peracetic acid; sulfamethazine; toxicity; Show all 10 Subjects
Abstract:
... In this study, a graphene shell-encapsulated copper-based nanoparticles (G@Cu-NPs) was prepared and employed for peracetic acid (PAA) activation. The characterization of G@Cu-NPs confirmed that the as-prepared material was composed of Cu⁰ and Cu₂O inside and encapsulated by a graphene shell. Experimental results suggested that the synthesized G@Cu-NPs could activate PAA to generate free radicals f ...
structure-activityrelationships, etc ; absorption; biomass; carbon; carbon dioxide; carbonization; electrochemistry; electron transfer; grana; oxidation; photosynthesis; solar radiation; synergism; thylakoids; xylose; Show all 15 Subjects
Abstract:
... Photosynthesis by plants stores sunlight into chemicals and drives CO₂ fixation into sugars with low biomass conversion efficiency due to the unoptimized solar spectrum utilization and various chemical conversion possibilities that follow H₂O oxidation. Expanding the solar spectrum utilization and optimizing the charge transfer pathway of photosynthesis is critical to improving the conversion effi ...
structure-activityrelationships, etc ; air; aluminum oxide; catalytic activity; humans; nitrogen; oxidation; pollution; solid wastes; sustainable development; value added; volatile organic compounds; China; Show all 13 Subjects
Abstract:
... Red mud, as a solid waste produced during the alumina production, can cause severe eco-environmental pollution and health risks to human. Therefore, the resourcing of this type of solid waste is an effective way for the sustainable development. This paper reviews the recent progress on red mud-based catalysts for the removal of typical air pollutants, such as the catalytic reduction of nitrogen ox ...
... Vacuum ultraviolet (VUV) photolysis is recognized as an environmental-friendly treatment process. Nitrate (NO₃⁻) and natural organic matter (NOM) are widely present in water source. We investigated trichloronitromethane (TCNM) formation during chlorination after VUV photolysis, because TCNM is an unregulated highly toxic disinfection byproduct. In this study: (1) we found reactive nitrogen species ...
quantitative structure-activityrelationships, etc ; aptasensors; crystal structure; deformation; detection limit; models; mutation; oligonucleotides; ricin; synergism; systematic evolution of ligands by exponential enrichment; Show all 11 Subjects
Abstract:
... Currently, many aptamers of different target molecules have been screened by systematic evolution of ligands by exponential enrichment (SELEX) method. However, since the crystal structure of aptamers is complicated to obtain, few studies focus on the quantitative structure activity relationship (QSAR) of aptamers. It is significant to develop a virtual screening method for aptamers based on the QS ...
quantitative structure-activityrelationships, etc ; Gibbs free energy; air; computer simulation; hexadecane; models; prediction; regression analysis; support vector machines; van der Waals forces; China; Show all 11 Subjects
Abstract:
... Predicting the logarithm of hexadecane/air partition coefficient (L) for organic compounds is crucial for understanding the environmental behavior and fate of organic compounds and developing prediction models with polyparameter linear free energy relationships. Herein, two quantitative structure activity relationship (QSAR) models were developed with 1272 L values for the organic compounds by usi ...
structure-activityrelationships, etc ; Pseudomonas aeruginosa; amino acids; catalytic activity; decolorization; fatty acids; half life; hydroperoxides; industrial applications; lipoxygenases; medicine; molecular dynamics; mutants; mutation; peroxidation; van der Waals forces; Show all 16 Subjects
Abstract:
... Lipoxygenase (LOX) catalyzes the peroxidation of unsaturated fatty acids to produce hydroperoxides, which had been widely used in food, medicine and chemical industries due to its decoloration of food and conversion of renewable oils. Thus, higher catalytic activity and stability is desired for low-cost and expanded industrial applications of LOX. To improve the catalytic activity of LOX, a mutant ...
structure-activityrelationships, etc ; Scorpiones; Swertia chirayita; antimalarials; antioxidants; chemical constituents of plants; diabetes; fever; flavonoids; heart; indigenous peoples; jaundice; malaria; medicinal plants; metabolites; pharmacology; quality control; secoiridoids; spectroscopy; therapeutics; toxicity; toxicology; traditional medicine; xanthones; Show all 24 Subjects
Abstract:
... Swertia chirayita (Roxb.) H. Karst. is a traditionally used, well-recognized medicinal plant of the family Gentianaceae with significant therapeutic potential. It has been traditionally used to cure various ailments such as fever, vomiting, jaundice, digestive disorders, heart diseases, diabetes, malaria, scorpion bite, and skin diseases. The present review emphasized the traditional uses, phytoch ...
structure-activityrelationships, etc ; fruits; polysaccharides; Show all 3 Subjects
Abstract:
... Zizylphus vulgaris has nearly four thousand years of planting and eating history. Zizylphus vulgaris polysaccharide is a kind of complex heteropolysaccharide. Modern pharmacological studies show that polysaccharide is one of the main functional active components in Zizylphus vulgaris fruit and has a variety of biological functions. Herein, the extraction methods of Zizylphus vulgaris polysaccharid ...
... Introducing fluoroalkyl chains into metallopolymers is a prerequisite to studying the self-organization effect of fluoroalkyl chains and their structure–property relationship. In this work, we present a fluorinated metallopolymer to build an alternating conduction-insulation “molecular fence” model synthesized by the coordination of Ru(ii) and a bis-terpyridine-end-capped-phenyl (BTP) ligand modif ...
structure-activityrelationships, etc ; anion exchange; energy; Show all 3 Subjects
Abstract:
... Ion-containing polymers have continued to be an important research focus for several decades due to their use as an electrolyte in energy storage and conversion devices. Elucidation of connections between the mesoscopic structure and multiscale dynamics of the ions and solvent remains incompletely understood. Coarse-grained modeling provides an efficient approach for exploring the structural and d ...
structure-activityrelationships, etc ; cytotoxicity; isoflavones; moieties; Show all 4 Subjects
Abstract:
... 4′-O-Methylgrynullarin 1 and its derivatives 2–4 showed preferential cytotoxicity under nutrient-deprived conditions without cytotoxicity under normal-nutrient conditions, indicating that its derivatives might have the potential to lead to novel anti-cancer agents based on anti-austerity strategy. The divergent synthesis of 4′-O-methylgrynullarin derivatives using the Suzuki-Miyaura coupling react ...
structure-activityrelationships, etc ; biocompatibility; biocompatible materials; immunization; Show all 4 Subjects
Abstract:
... Cancer immunotherapy has achieved promising clinical results. However, many limitations associated with current cancer immunotherapy still exist, including low response rates and severe adverse effects in patients. Engineering biomaterials for the delivery of immunotherapeutic reagents has been suggested to be an effective strategy to improve cancer immunotherapy. Among different biomaterials, sup ...
structure-activityrelationships, etc ; crystallization; enantiomers; industrialization; temperature; Show all 5 Subjects
Abstract:
... Poly(3-hydroxybutyrate) (PHB) is naturally accumulated by bacteria but can also be synthesized chemically. Its processability is limited, as it tends to degrade at temperatures above its melting temperature; hence, investigation into crystallization kinetics and morphology of PHB materials of both natural and synthetic origins is of great need and interest to get a better understanding of structur ...
structure-activityrelationships, etc ; bioactive properties; organic matter; polysaccharides; Show all 4 Subjects
Abstract:
... Plant polysaccharides represent a natural source material characterized by high ubiquity, abundance and biological activities that can be utilised as organic matter in numerous manufacturing processes including pharmaceutical. The goal-oriented modification of polysaccharides by chemical reactions brings about a substantial refinement in their molecular features and biological activity. An improve ...
structure-activityrelationships, etc ; amyloid; mass spectrometry; molecular biology; Show all 4 Subjects
Abstract:
... α-Synuclein (α-Syn) amyloids in synucleinopathies are suggested to be structurally and functionally diverse, reminiscent of prion-like strains. The mechanism of how the aggregation of the same precursor protein results in the formation of fibril polymorphs remains elusive. Here, we demonstrate the structure–function relationship of two polymorphs, pre-matured fibrils (PMFs) and helix-matured fibri ...
structure-activityrelationships, etc ; fluorescence; humans; prostaglandin synthase; pyrroles; Show all 5 Subjects
Abstract:
... Recent studies have demonstrated the ability of human prostaglandin-endoperoxide synthase 2 (COX-2) to guide the formation of fluorescent pyrroles through the Paal-Knorr reaction resulting in the discovery of a central motif. This initial discovery prompted further exploration of this motif for the design of COX-2 inhibitors through the modifications of the substituents on the pyrrole core. This e ...