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1. Balenine, imidazole dipeptide, induces activation of superoxide dismutase in myotubes

Author:
Min Yang; Luchuanyang Sun; Yasunosuke Kawabata; Takahiro Maegawa; Shigeto Taniyama; Katsuyasu Tachibana; Katsuya Hirasaka
Source:
Fisheries science 2021 v.87 no.3 pp. 403-409
ISSN:
0919-9268
Subject:
superoxide dismutase,   etc   ; antioxidant activity; beta-alanine; brain; carnosine; hydrogen peroxide; imidazole; myotubes; superoxide anion;     Show all 9 Subjects
Abstract:
... Balenine is one of the endogenous imidazole dipeptides. It is composed of beta-alanine and 3-methyl-L-histidine, which exist mainly in the muscles and the brain. The exact biological properties of balenine are still not well known, although the antioxidant activity of carnosine, another imidazole dipeptide, is known. In this study we investigated whether balenine exhibits antioxidant activity. It ...
DOI:
10.1007/s12562-021-01516-7

2. Extracellular superoxide dismutase VdSOD5 is required for virulence in Verticillium dahliae

Author:
Li TIAN; Cai-min HUANG; Dan-dan ZHANG; Ran LI; Jie-yin CHEN; Wei-xia SUN; Nian-wei QIU; Xiao-feng DAI
Source:
Journal of integrative agriculture 2021 v.20 no.7 pp. 1858-1870
ISSN:
2095-3119
Subject:
superoxide dismutase,   etc   ; Verticillium dahliae; agriculture; conidia; cotton; culture filtrates; loss-of-function mutation; menadione; nitroblue tetrazolium; pathogens; protein secretion; signal peptide; superoxide anion; vegetative growth; virulence; yeasts;     Show all 16 Subjects
Abstract:
... Plants produce reactive oxygen species (ROS) to defend pathogens. To counteract this attack, certain pathogens express superoxide dismutases (SODs) to scavenge host-derived ROS. However, the roles of SODs in Verticillium dahliae, an important vascular pathogen, are not clear. Our previous study has shown that a putative extracellular SOD (VdSOD5) of V. dahliae is significantly induced ...
DOI:
10.1016/S2095-3119(20)63353-6

3. Human superoxide dismutase 1 attenuates quinoneimine metabolite formation from mefenamic acid

Author:
Takuo Ogiso; Tatsuki Fukami; Cheng Zhongzhe; Keigo Konishi; Masataka Nakano; Miki Nakajima
Source:
Toxicology 2021 v.448 pp. 152648
ISSN:
0300-483X
Subject:
superoxide dismutase,   etc   ; NAD (coenzyme); NAD(P)H dehydrogenase (quinone); NADP (coenzyme); acetaminophen; chromatography; cytochrome P-450; cytosol; cytotoxicity; diclofenac; glutathione; human cell lines; humans; lactate dehydrogenase; liver; metabolites; nonsteroidal anti-inflammatory agents; oxidation; quinones; small interfering RNA; structure-activity relationships;     Show all 21 Subjects
Abstract:
... chromatography, superoxide dismutase 1 (SOD1) was identified from the human liver cytosol as an enzyme decreasing MFA-quinoneimine formation. Addition of recombinant SOD1 into the reaction mixture decreased the formation of MFA-quinoneimine from MFA by recombinant CYP1A2. By a structure-activity relationship study, we found that SOD1 decreased the formation of quinoneimines from flufenamic acid and tolfenamic ...
DOI:
10.1016/j.tox.2020.152648

4. Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway

Author:
Bindu Chandrasekharan; Claudia Montllor-Albalate; Alyson E. Colin; Joshua L. Andersen; Young C. Jang; Amit R. Reddi
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 720-726
ISSN:
0006-291X
Subject:
superoxide dismutase,   etc   ; Saccharomyces cerevisiae; adults; cell proliferation; cytotoxicity; early development; energy metabolism; glucose; glycolysis; humans; hydrogen peroxide; kidneys; non-specific serine/threonine protein kinase; nutrient availability; oxygen; plasma membrane; research; yeasts;     Show all 18 Subjects
Abstract:
... Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O₂•⁻) into oxygen (O₂) and hydrogen peroxide (H₂O₂), a key signaling molecule. In Saccharomyces cerevisiae, we previously discovered that Sod1 participates in an H₂O₂-mediated redox signaling circuit that links nutrient availability to the control of energy metabolism. In response to glucose and O ...
DOI:
10.1016/j.bbrc.2020.11.011

5. Structural effects of stabilization and complexation of a zinc-deficient superoxide dismutase

Author:
Tania M. Manieri; Stefano L. Sensi; Rosanna Squitti; Giselle Cerchiaro
Source:
Heliyon 2021 v.7 no.1 pp. e06100
ISSN:
2405-8440
Subject:
superoxide dismutase,   etc   ; Alzheimer disease; active sites; amino acids; antioxidant enzymes; circular dichroism spectroscopy; copper; enzyme activity; erythrocytes; models; mutants; mutation; titration; zinc;     Show all 14 Subjects
Abstract:
... The activity of the erythrocyte Cu₂,Zn₂-superoxide dismutase (SOD1) is altered in Alzheimer's disease (AD) patients. These patients, compared to healthy subjects, exhibit low plasmatic zinc (Zn) levels in the presence of high plasmatic levels of copper (Cu). SOD1 is an antioxidant enzyme characterized by the presence of two metal ions, Cu and Zn, on its active site. On the SOD1, Cu exerts ...
DOI:
10.1016/j.heliyon.2021.e06100

6. A pH Switch Controls Zinc Binding in Tomato Copper–Zinc Superoxide Dismutase

Author:
Kevin W. Sea; Alexander B. Taylor; Susan T. Thomas; Amir Liba; Isabelle B. Bergman; Stephen P. Holloway; Xiaohang Cao; Edith B. Gralla; Joan S. Valentine; P. John Hart; Ahmad Galaleldeen
Source:
Biochemistry 2021 v.60 no.20 pp. 1597-1608
ISSN:
1520-4995
Subject:
superoxide dismutase,   etc   ; cattle; chloroplasts; cobalt; fungi; humans; hydrogen bonding; ligands; pH; tomatoes; zinc;     Show all 11 Subjects
Abstract:
... Copper–zinc superoxide dismutase (SOD1) is a major antioxidant metalloenzyme that protects cells from oxidative damage by superoxide anions (O₂–). Structural, biophysical, and other characteristics have in the past been compiled for mammalian SOD1s and for the highly homologous fungal and bovine SOD1s. Here, we characterize the biophysical properties of a plant SOD1 from tomato chloroplasts ...
DOI:
10.1021/acs.biochem.1c00133

7. Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches

Author:
Arianna Carolina Rosa; Natascia Bruni; Giorgia Meineri; Daniele Corsi; Niccolò Cavi; Daniela Gastaldi; Franco Dosio
Source:
International journal of biological macromolecules 2021 v.168 pp. 846-865
ISSN:
0141-8130
Subject:
superoxide dismutase,   etc   ; bioavailability; micelles; oxidative stress; risk reduction; therapeutics;     Show all 6 Subjects
Abstract:
... The overproduction of free radicals can cause oxidative-stress damage to a range of biomolecules, and thus potentially contribute to several pathologies, from neurodegenerative disorders to cardiovascular diseases and metabolic disorders. Endogenous antioxidant enzymes, such as superoxide dismutase (SOD), play an important role in diminishing oxidative stress. SOD supplementation could therefore ...
DOI:
10.1016/j.ijbiomac.2020.11.149

8. Rescue the retina after the ischemic injury by polymer-mediated intracellular superoxide dismutase delivery

Author:
Xujiao Zhou; Jia Lv; Gang Li; Tingting Qian; Hao Jiang; Jianjiang Xu; Yiyun Cheng; Jiaxu Hong
Source:
Biomaterials 2021 v.268 pp. 120600
ISSN:
0142-9612
Subject:
superoxide dismutase,   etc   ; apoptosis; biocompatible materials; cytotoxicity; ganglia; glutathione; intravitreal injection; ischemia; malondialdehyde; models; oxidative stress; polymers; retina; therapeutics;     Show all 14 Subjects
Abstract:
... Oxidative stress is a hallmark of the pathophysiogenesis of retinal ischemia. The direct delivery of antioxidant enzymes such as superoxide dismutase (SOD) into retinal cells provides a promising option for the down-regulation of oxidative stress in retinal ischemia, however, efficient intracellular protein delivery remains a major challenge for this application. Here, a boronic acid-rich polymer ...
DOI:
10.1016/j.biomaterials.2020.120600

9. Up-regulated spinal microRNAs induce aggregation of superoxide dismutase 1 protein in canine degenerative myelopathy

Author:
Kohei Nakata; Mariko Namiki; Yui Kobatake; Hidetaka Nishida; Hiroki Sakai; Osamu Yamato; Makoto Urushitani; Sadatoshi Maeda; Hiroaki Kamishina
Source:
Research in veterinary science 2021 v.135 pp. 479-485
ISSN:
0034-5288
Subject:
superoxide dismutase,   etc   ; dogs; gene ontology; genes; immunohistochemistry; microRNA; mutants; neurodegenerative diseases; research; risk factors; spinal cord; toxicity; ubiquitin; ubiquitination; veterinary medicine;     Show all 15 Subjects
Abstract:
... Canine degenerative myelopathy (DM) is a fatal progressive neurodegenerative disease. Mutations in the superoxide dismutase 1 (SOD1) gene have been shown to be the major risk factor for DM, and it is hypothesized that neural degeneration is caused by a “gain of toxic function” of mutant SOD1. In this study, the spinal cord microRNA (miRNA) profiles of DM-affected dogs were investigated ...
DOI:
10.1016/j.rvsc.2020.11.018

10. Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria

Author:
Aping Niu; Wan-Ping Bian; Shuang-Long Feng; Shi-Ya Pu; Xing-Yi Wei; Yi-Fan Yang; Li-Yan Song; De-Sheng Pei
Source:
Journal of hazardous materials 2021 v.403 pp. 123604
ISSN:
0304-3894
Subject:
superoxide dismutase,   etc   ; bacterial growth; lipid peroxidation; oxidation; oxidative stress; reactive oxygen species; stress tolerance; toxicity;     Show all 8 Subjects
Abstract:
... The toxicity of Cr(VI) was widely investigated, but the defense mechanism against Cr(III) in bacteria are seldom reported. Here, we found that Cr(III) inhibited bacterial growth and induced reactive oxygen species (ROS). After exposure to Cr(III), loss of sodA not only led to the excessive generation of ROS, but also enhanced the level of lipid peroxidation and reduced the GSH level, indicating th ...
DOI:
10.1016/j.jhazmat.2020.123604

11. Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 β-Barrel

Author:
Naoto Iwakawa; Daichi Morimoto; Erik Walinda; Sarah Leeb; Masahiro Shirakawa; Jens Danielsson; Kenji Sugase
Source:
Journal of physical chemistry 2021 v.125 no.10 pp. 2521-2532
ISSN:
1520-5207
Subject:
superoxide dismutase,   etc   ; amyotrophic lateral sclerosis; etiology; lysozyme; physical chemistry; thermodynamics;     Show all 6 Subjects
Abstract:
... Aggregate formation of superoxide dismutase 1 (SOD1) inside motor neurons is known as a major factor in onset of amyotrophic lateral sclerosis. The thermodynamic stability of the SOD1 β-barrel has been shown to decrease in crowded environments such as inside a cell, but it remains unclear how the thermodynamics of crowding-induced protein destabilization relate to SOD1 aggregation. Here we have ...
DOI:
10.1021/acs.jpcb.0c11162

12. Changes in transcript levels of cassava superoxide dismutase and catalase during interaction with Phytopythium sp.

Author:
Daihany Moraes Callegari; Aline Medeiros Lima; Nicolle Louise Ferreira Barros; Andrei Santos Siqueira; Elisa Ferreira Moura; Cláudia Regina Batista de Souza
Source:
Physiological and molecular plant pathology 2021 v.114 pp. 101629
ISSN:
0885-5765
Subject:
superoxide dismutase,   etc   ; Hevea brasiliensis; Jatropha curcas; Manihot esculenta; Oomycetes; cassava; catalase; genes; genetic databases; host-pathogen relationships; isozymes; mitochondria; phylogeny; plant pathology; root rot; sequence analysis; Amazonia; Brazil;     Show all 18 Subjects
Abstract:
... Among the biotic factors affecting the production of cassava (Manihot esculenta Crantz), root rot is one of the most severe diseases worldwide. In northern Brazil, the oomycete Phytopythium sp. causes cassava soft root rot disease in the Amazon region. Seeking to understand this plant-pathogen interaction, our main aim was to evaluate changes in expression levels of superoxide dismutase (SOD ...
DOI:
10.1016/j.pmpp.2021.101629

13. Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase

Author:
Xiangshi Sun; Kongtong Yu; Yulin Zhou; Shiyan Dong; Wenji Hu; Yating Sun; Yuhuan Li; Jing Xie; Robert J. Lee; Fengying Sun; Yifan Ma; Shengnian Wang; Betty Y. S. Kim; Yifan Wang; Zhaogang Yang; Wen Jiang; Youxin Li; Lesheng Teng
Source:
ACS applied materials & interfaces 2021 v.13 no.15 pp. 18152-18164
ISSN:
1944-8252
Subject:
superoxide dismutase,   etc   ; acetone; antioxidants; arthritis; biocompatibility; composite polymers; half life; hydrolysis; inflammation; micelles; models; peritonitis; pharmacodynamics; rats;     Show all 14 Subjects
Abstract:
... The use of superoxide dismutase (SOD) is currently limited by its short half-life, rapid plasma clearance rate, and instability. We synthesized a small library of biofriendly amphiphilic polymers that comprise methoxy poly(ethylene glycol)-poly(cyclohexane-1,4-diyl acetone dimethyleneketal) (mPEG-PCADK) and mPEG-poly((cyclohexane₈₆.₇%, 1,5-pentanediol₁₃.₃%)-1,4-diyl acetone dimethylene ketal ...
DOI:
10.1021/acsami.1c03589

14. ALM1, encoding a Fe-superoxide dismutase, is critical for rice chloroplast biogenesis and drought stress response

Author:
Yanwei Wang; Chen Deng; Pengfei Ai; Xue'an Cui; Zhiguo Zhang
Source:
crop journal 2021 v.9 no.5 pp. 1018-1029
ISSN:
2214-5141
Subject:
superoxide dismutase,   etc   ; DNA-directed RNA polymerase; Western blotting; albino; assays; biogenesis; chlorophyll; chloroplasts; drought tolerance; genes; leaves; mutants; oxygen; photosynthesis; rice; seedlings; stress response; stress tolerance; transmission electron microscopy; water stress;     Show all 20 Subjects
Abstract:
... that chloroplast development in alm1 was blocked, especially in thylakoid-like structures, which could not form normally. The ALM1 gene encodes a chloroplast-localized superoxide dismutase. Full-length ALM1 successfully restored the non-albino phenotype, and in knockout lines, the albino phenotype reappeared. The ALM1 gene is expressed mainly in young leaves. alm1 plants died as a consequence of excessive ...
DOI:
10.1016/j.cj.2020.09.013

15. Degenerative Myelopathy in Hovawart Dogs: Molecular Characterization, Pathological Features and Accumulation of Mutant Superoxide Dismutase 1 Protein

Author:
Luciana Mandrioli; Gualtiero Gandini; Fabio Gentilini; Roberto Chiocchetti; Maria E. Turba; Giancarlo Avallone; Valeria Pellegrino; Marika Menchetti; Yui Kobatake; Hiroaki Kamishina; Carlo Cantile
Source:
Journal of comparative pathology 2021 v.182 pp. 37-42
ISSN:
0021-9975
Subject:
superoxide dismutase,   etc   ; age; alleles; amino acid substitution; antibodies; astrocytes; ataxia (disorder); dog breeds; dogs; genetic testing; haplotypes; heterozygosity; homozygosity; loci; muscular atrophy; mutants; neurodegenerative diseases; neurons; risk;     Show all 19 Subjects
Abstract:
... Degenerative myelopathy (DM) is an adult-onset, progressive neurological disease affecting several breeds of dog. Homozygosity or compound heterozygosity for the canine superoxide dismutase 1 (SOD1) gene mutations, possibly modulated by the modifier SP110 locus, are associated with a high risk for DM. Although the pathophysiological mechanisms are largely unknown, a role for mutant SOD1 ...
DOI:
10.1016/j.jcpa.2020.11.006

16. Immune function of cytosolic manganese superoxide dismutase from Macrobrachium rosenbergii in response to bacterial infection

Author:
Yanan Li; Fanbin Zhan; Fenglin Li; Zhijie Lu; Fei Shi; Zizheng Xu; Youcheng Yang; Lijuan Zhao; Zhendong Qin; Li Lin
Source:
Aquaculture 2021 v.541 pp. 736771
ISSN:
0044-8486
Subject:
superoxide dismutase,   etc   ; Macrobrachium rosenbergii; RNA; Staphylococcus aureus; Vibrio parahaemolyticus; agglutination; antioxidant activity; aquaculture; bacterial infections; disease prevention; gene expression; hemocytes; hepatopancreas; homeostasis; immune system; innate immunity; intestines; mortality; oxidative stress; pathogens; reactive oxygen species; stomach;     Show all 22 Subjects
Abstract:
... An excess of reactive oxygen species (ROS) usually disrupts the balance of the antioxidant system and impairs the homeostasis of cells, resulting in serious oxidative damage. Therefore, a better understanding of how the immune system protects itself against such excessive oxidative stress is crucial. SODs play an indispensable role in antioxidant defense and the innate immune system. Among those, ...
DOI:
10.1016/j.aquaculture.2021.736771

17. Dry powder inhaler formulation of Cu,Zn-superoxide dismutase by spray drying: A proof-of-concept

Author:
Diana A. Fernandes; Paula Leandro; Eunice Costa; M. Luísa Corvo
Source:
Powder technology 2021 v.389 pp. 131-137
ISSN:
0032-5910
Subject:
active pharmaceutical ingredients; aerodynamics; atomization; cystic fibrosis; enzyme activity; enzymes; fluorometry; oxidative stress; rheumatoid arthritis; spectroscopy; spray drying; statistical analysis; temperature
Abstract:
... work describes a proof-of-concept study to investigate the effect of spray drying (SD) outlet temperature (Tₒᵤₜ), atomization flow rate (Rotₐₜₒₘ) and feed flow rate (Ffₑₑd) on powder properties such as particle morphology and aerodynamic performance but also on the enzyme activity and protein conformational stability of a trehalose:leucine spray-dried powder featuring Cu,Zn-superoxide dismutase (Cu ...
DOI:
10.1016/j.powtec.2021.05.008

18. Identification of a secreted superoxide dismutase (SOD) from Nocardia seriolae which induces apoptosis in fathead minnow (FHM) cells

Author:
Suying Hou; Wenji Wang; Guoquan Chen; Liqun Xia; Zhiwen Wang; Yishan Lu
Source:
Journal of fish diseases 2021 v.44 no.1 pp. 63-72
ISSN:
0140-7775
Subject:
superoxide dismutase,   etc   ; Nocardia seriolae; Pimephales promelas; apoptosis; bioinformatics; caspase-3; cytoplasm; databases; fish; genes; membrane potential; mitochondrial membrane; nocardiosis; nucleotide sequences; pathogenesis; pathogens; virulence;     Show all 17 Subjects
Abstract:
... Fish nocardiosis is a chronic systemic granulomatous disease, and Nocardia seriolae is the main pathogen. The pathogenesis and virulence factors of N. seriolae are not fully understood. Secreted superoxide dismutase (SOD) may be a virulence factor found by a comparative bioinformatics analysis of the whole genome sequence of N. seriolae and the virulence factor database (VFDB). In order ...
DOI:
10.1111/jfd.13268

19. In vivo light‐sheet microscopy resolves localisation patterns of FSD1, a superoxide dismutase with function in root development and osmoprotection

Author:
Petr Dvořák; Yuliya Krasylenko; Miroslav Ovečka; Jasim Basheer; Veronika Zapletalová; Jozef Šamaj; Tomáš Takáč
Source:
Plant, cell and environment 2021 v.44 no.1 pp. 68-87
ISSN:
0140-7791
Subject:
superoxide dismutase,   etc   ; Arabidopsis; confocal microscopy; cortex; cytosol; endodermis; endosperm; environment; fluorescence recovery after photobleaching; genetic complementation; hydrogen peroxide; lateral roots; oxidative stress; phenotype; root cap; salt stress; seed germination; stress tolerance;     Show all 18 Subjects
Abstract:
... Superoxide dismutases (SODs) are enzymes detoxifying superoxide to hydrogen peroxide while temporal developmental expression and subcellular localisation are linked to their functions. Therefore, we aimed here to reveal in vivo developmental expression, subcellular, tissue‐ and organ‐specific localisation of iron superoxide dismutase 1 (FSD1) in Arabidopsis using light‐sheet and Airyscan confocal ...
DOI:
10.1111/pce.13894

20. Comparative genomic analysis of superoxide dismutase (SOD) genes in three Rosaceae species and expression analysis in Pyrus bretschneideri

Author:
Guohui Li; Fei Hu; Yang Zhang; Yu Zhao; Han Wang; Tianzhe Chen; Xi Cheng; Yongping Cai
Source:
Physiology and molecular biology of plants 2021 v.27 no.1 pp. 39-52
ISSN:
0971-5894
Subject:
superoxide dismutase,   etc   ; Pyrus bretschneideri; evolution; gene expression; genes; genomics; growth and development; hydrogen peroxide; lignification; lignin; lignin content; metabolism; molecular biology; pears; plant growth; polymerization;     Show all 16 Subjects
Abstract:
... Superoxide dismutases (SODs) are antioxidant enzymes that play a critical role in the polymerization of lignin monomers. Although current research has indicated that SODs are involved in plant growth and development, information on SODs in pear (Pyrus bretschneideri) and their function in lignin formation is scarce. In this study, 25 SODs, containing three kinds of plant SODs (Cu/Zn-SODs, Mn-SODs ...
DOI:
10.1007/s12298-021-00926-2