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1. Hyptis suaveolens (L.) Poit protects colon from TNBS-induced inflammation via immunomodulatory, antioxidant and anti-proliferative mechanisms

Author:
Machado, Flávia Danniele Frota; Formiga, Rodrigo de Oliveira; Lima, Gedson Rodrigues de Morais; de Jesus, Neyres Zínia Taveira; Alves Júnior, Edvaldo Balbino; Marinho, Alexsandro Fernandes; Tavares, Josean Fechine; Santos, Flávia Almeida; Viana, Ana Flávia Seraine Custódio; Araújo, Aurigena Antunes; de Araújo Júnior, Raimundo Fernandes; Pellizzon, Cláudia Helena; Batista, Leônia Maria
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113153
ISSN:
0378-8741
Subject:
superoxide dismutase,   etc   ; Hyptis suaveolens; anti-inflammatory activity; antioxidants; catalase; cell proliferation; colon; edema; gastrointestinal diseases; hexane; histology; inflammation; interleukin-10; interleukin-1beta; mechanism of action; models; neutrophils; nitrates; nitrites; relapse; traditional medicine; tumor necrosis factor-alpha; ulcerative colitis;     Show all 23 Subjects
Abstract:
... In folk medicine Hyptis suaveolens (Lamiaceae) has been reported to relieve respiratory and gastrointestinal infections, indigestion, cold, pain, fever, cramps, skin diseases, gastric ulcer and inflammatory disorders. This study investigated the effects and the mechanisms of action of Hyptis suaveolens (L.) Poit (Lamiaceae) ethanol extract (Hs-EtOH) and hexane phase (Hs-HexF) against intestinal in ...
DOI:
10.1016/j.jep.2020.113153

2. Conformational dynamics of superoxide dismutase (SOD1) in osmolytes: a molecular dynamics simulation study

Author:
Jahan, Ishrat; Nayeem, Shahid M.
Source:
RSC advances 2020 v.10 no.46 pp. 27598-27614
ISSN:
2046-2069
Subject:
superoxide dismutase,   etc   ; amyotrophic lateral sclerosis; hydrophobicity; molecular dynamics; trimethylamine; urea;     Show all 6 Subjects
Abstract:
... Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by the misfolding of Cu, Zn superoxide dismutase (SOD1). Several earlier studies have shown that monomeric apo SOD1 undergoes significant local unfolding dynamics and is the predecessor for aggregation. Here, we have employed atomistic molecular dynamics (MD) simulations to study the structure and dynamics of mon ...
DOI:
10.1039/d0ra02151b

3. Ethanolic Garcinia mangostana extract and α-mangostin improve dextran sulfate sodium-induced ulcerative colitis via the suppression of inflammatory and oxidative responses in ICR mice

Author:
Tatiya-aphiradee, Nitima; Chatuphonprasert, Waranya; Jarukamjorn, Kanokwan
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113384
ISSN:
0378-8741
Subject:
superoxide dismutase,   etc   ; Garcinia mangostana; Toll-like receptors; adhesion; antioxidant activity; catalase; chemoattractants; colon; dextran sulfate; enzyme activity; gene expression; gene expression regulation; genes; histology; intercellular adhesion molecule-1; kidneys; malondialdehyde; mast cells; messenger RNA; mice; monocytes; myeloperoxidase; nitric oxide; oral administration; plant extracts; reactive oxygen species; spleen; sulfasalazine; traditional medicine; tumor necrosis factor-alpha; ulcerative colitis; vascular cell adhesion molecules;     Show all 32 Subjects
Abstract:
... Ulcerative colitis (UC) is an inflammatory disorder of the colon. Garcinia mangostana Linn. (GM) has been traditionally used for its anti-inflammatory and antioxidant activities.The effects of GM and its bioactive constituent α-mangostin on dextran sulfate sodium (DSS)-induced UC in mice were investigated.Adult ICR mice (n = 63) were pretreated with ethanolic GM extract at 40, 200, and 1000 mg/kg/ ...
DOI:
10.1016/j.jep.2020.113384

4. Pharmacological and pharmacokinetic effect of a polyherbal combination with Withania somnifera (L.) Dunal for the management of anxiety

Author:
Muhasaparur Ganesan, Rajanandh; Settu, Dinesh Kumar; Murkunde, Yogeshkumar; Duraipandian, Chamundeeswari
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113337
ISSN:
0378-8741
Subject:
superoxide dismutase,   etc   ; Aegle marmelos; Correa; Hemidesmus indicus; Ocimum tenuiflorum; Phyllanthus emblica; Withania somnifera; antioxidant activity; antioxidants; anxiety; brain; elevated plus-maze test; gamma-aminobutyric acid; glutathione; half life; lipid peroxidation; liquid chromatography; mass spectrometry; models; oral administration; pharmacokinetics; rats; screening; traditional medicine; tranquilizers;     Show all 25 Subjects
Abstract:
... In the Indian system of medicine, Withania somnifera (L.) Dunal, Hemidesmus indicus (R.Br.), Aegle marmelos (L.) Correa, Emblica officinalis Gaertn, Ocimum sanctum (L.) has been mentioned as a remedy for the treatment of anxiety related disorders. Based on their folklore use, a polyherbal combination was derived for the management of anxiety.The present study is aimed to find the best polyherbal c ...
DOI:
10.1016/j.jep.2020.113337

5. Pilosocereus gounellei (Cactaceae) stem extract decreases insulin resistance, inflammation, oxidative stress, and cardio-metabolic risk in diet-induced obese mice

Author:
de Oliveira, Alisson Macário; de Freitas, Anderson Felipe Soares; Costa, Milena Damasceno de Souza; Torres, Marília Kalinne da Silva; Castro, Yasmim Alline de Araújo; Almeida, Ana Maria Rampeloti; Paiva, Patrícia Maria Guedes; Carvalho, Bruno Melo; Napoleão, Thiago Henrique
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113327
ISSN:
0378-8741
Subject:
superoxide dismutase,   etc   ; Pilosocereus; animal disease models; blood lipids; blood serum; caatinga; cacti and succulents; chemokine CCL2; collagen; epididymis; flavonoids; glucose; high density lipoprotein cholesterol; high fat diet; histology; hyperglycemia; inflammation; insulin resistance; interleukin-6; lipid composition; lipid peroxidation; liver; low density lipoprotein cholesterol; metformin; mice; muscles; obesity; oxidative stress; relative risk; risk reduction; sodium chloride; stem extracts; traditional medicine; triacylglycerols; tumor necrosis factor-alpha;     Show all 35 Subjects
Abstract:
... Pilosocereus gounellei (xique-xique) is a popular cactus from Caatinga, traditionally used to counter inflammatory processes and indicated as a hypoglycemic agent. Previous studies have shown that mice treated orally with saline extract of P. gounellei stem (containing flavonoids and sugars) showed decreased serum lipid levels.In this work, we evaluated whether this extract would have beneficial e ...
DOI:
10.1016/j.jep.2020.113327

6. Abatement of neurobehavioral and neurochemical dysfunctions in cerebral ischemia/reperfusion injury by Tetrapleura tetraptera fruit extract

Author:
Saliu, Ibrahim Olabayode; Amoo, Zainab Abiola; Khan, Mohammad Faheem; Olaleye, M. Tolulope; Rema, Velayudhan; Akinmoladun, Afolabi C.
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113284
ISSN:
0378-8741
Subject:
superoxide dismutase,   etc   ; Tetrapleura tetraptera; acetylcholinesterase; adenosinetriphosphatase; behavior disorders; bioactive compounds; bioactive properties; carotid arteries; catalase; dopamine; electrolytes; enzyme activity; fruit extracts; fruits; glutamate-ammonia ligase; glutathione; high performance liquid chromatography; hippocampus; histology; histopathology; ischemia; lactate dehydrogenase; leaves; lipid peroxidation; lowland forests; males; metabolism; methanol; myeloperoxidase; neurotransmitters; oxidative stress; potassium; reperfusion injury; sodium; stroke; traditional medicine; xanthine oxidase; Western Africa;     Show all 38 Subjects
Abstract:
... Tetrapleura tetraptera Taub. (family Fabaceae), is generally found in the lowland forest of tropical Africa. Its leaves and fruits are traditionally used in West Africa for the management of brain disorders.This study evaluated the effect of Tetrapleura tetraptera methanol fruit extract (TT) on bilateral common carotid artery occlusion-induced cerebral ischemia/reperfusion (I/R) injury in male Wis ...
DOI:
10.1016/j.jep.2020.113284

7. Thalictrum minus L. ameliorates particulate matter-induced acute lung injury in mice

Author:
Badamjav, Rentsen; Zhang, Lu; Sonom, Dolgor; Wu, Yun-Hao; Kou, Jun-Ping; Yu, Bo-Yang; Li, Fang
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113379
ISSN:
0378-8741
Subject:
superoxide dismutase,   etc   ; Thalictrum minus; animal models; apoptosis; berberine; body weight; caspase-1; enzyme inhibition; fungi; high performance liquid chromatography; inflammation; interleukin-1beta; interleukin-6; leukocytes; lungs; macrophages; medicinal plants; mice; myeloperoxidase; nitric oxide; particulates; prostaglandin synthase; protein content; qualitative analysis; quantitative analysis; respiratory tract diseases; signal transduction; traditional medicine; tuberculosis; tumor necrosis factor-alpha; weight loss; Eurasia;     Show all 32 Subjects
Abstract:
... Thalictrum minus L., which is widespread across Eurasia, is utilized as a folk medicine for treating dysentery, bedsore, fungal infection and lung inflammation in China, Mongolia and Iran.A Mongolian folk medicinal plant named Thalictrum minus L. (TML) has been extensively used for the treatment of lung inflammation, bacterial and fungal infection and tuberculosis. Our present study aims to invest ...
DOI:
10.1016/j.jep.2020.113379

8. An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury

Author:
liu, Chang; Yin, Zhigang; Feng, Tingting; Zhang, Min; Zhou, Zhi; Zhou, Ying
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113364
ISSN:
0378-8741
Subject:
superoxide dismutase,   etc   ; Lonicera japonica; active ingredients; amyloid beta-peptides; animal models; blood serum; chemokine CXCL1; chemokine CXCL2; chemokine CXCL6; databases; dexamethasone; enzyme activity; flower buds; flowers; gelatinase B; gene expression; gene expression regulation; genes; glutathione peroxidase; herbal medicines; immune response; in vivo studies; inflammation; interferon-gamma; interleukin-1; interleukin-17; interleukin-6; lungs; oxidative stress; pharmacology; prostaglandin synthase; protective effect; quantitative polymerase chain reaction; respiratory tract diseases; reverse transcriptase polymerase chain reaction; sequence analysis; signal transduction; traditional medicine; tumor necrosis factors;     Show all 39 Subjects
Abstract:
... Lonicerae japonicae flos (LJF, the dried flower bud or newly bloomed flower of Lonicera japonica Thunb.), a typical herbal medicine, targets the lung, heart and stomach meridian with the function of clearing heat and detoxication. It ameliorated inflammatory responses and protected against acute lung inflammation in animal models. Acute lung injury (ALI) is a kind of inflammatory disease in which ...
DOI:
10.1016/j.jep.2020.113364

9. Effect of low power laser irradiation on bio-physical properties of wheat seeds

Author:
Samiya,; Aftab, Sikandar; Younus, Ayesha
Source:
Information processing in agriculture 2020 v.7 no.3 pp. 456-465
ISSN:
2214-3173
Subject:
superoxide dismutase,   etc   ; Triticum; catalase; diodes; exercise; germination; irradiation; peroxidase; seeds; wheat;     Show all 10 Subjects
Abstract:
... The production of quality food is indispensable and essential to overcome its global shortage. In order to exercise the facile route to acquire massive production, a laser irradiation treatment method was established. We have investigated the effects of diode laser irradiation on wheat seeds germination, its early growth and biochemical parameters. The variation in germination parameters, caused b ...
DOI:
10.1016/j.inpa.2019.12.003

10. Effects of probiotic administration on hepatic antioxidative parameters depending on oxidative stress models: A meta-analysis of animal experiments

Author:
Zhao, Jichun; Yu, Leilei; Zhai, Qixiao; Tian, Fengwei; Zhang, Hao; Chen, Wei
Source:
Journal of functional foods 2020 v.71 pp. 103936
ISSN:
1756-4646
Subject:
superoxide dismutase,   etc   ; animal experimentation; confidence interval; glutathione peroxidase; malondialdehyde; meta-analysis; models; oxidative stress; probiotics;     Show all 9 Subjects
Abstract:
... Hepatic antioxidative substances are critical indicators to characterize the degree of oxidative stress in the body. The overall effects of probiotic administration on hepatic superoxide dismutase (SOD) activity and glutathione peroxidase (GSH-PX) activity and malondialdehyde (MDA) content were systematically evaluated through determining standardised mean difference (SMD). As a result, the meta-a ...
DOI:
10.1016/j.jff.2020.103936

11. Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex

Author:
Mathieu, Emilie; Bernard, Anne-Sophie; Quévrain, Elodie; Zoumpoulaki, Martha; Iriart, Sébastien; Lung-Soong, Caroline; Lai, Barry; Medjoubi, Kadda; Henry, Lucas; Nagarajan, Sounderya; Poyer, Florent; Scheitler, Andreas; Ivanović-Burmazović, Ivana; Marco, Sergio; Somogyi, Andrea; Seksik, Philippe; Delsuc, Nicolas; Policar, Clotilde
Source:
Chemical communications 2020 v.56 no.57 pp. 7885-7888
ISSN:
1364-548X
Subject:
superoxide dismutase,   etc   ; anti-inflammatory activity; chemical reactions; manganese; mitochondria; models; oxidative stress;     Show all 7 Subjects
Abstract:
... A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1̲ was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1̲ shows a distribution different from its unconjugated analogue but a similar concentration in mitochondria and a similar bioactivity. ...
DOI:
10.1039/d0cc03398g

12. Unveiling the reaction mechanism of novel copper N-alkylated tetra-azacyclophanes with outstanding superoxide dismutase activity

Author:
Martínez-Camarena, Álvaro; Sánchez-Murcia, Pedro A.; Blasco, Salvador; González, Leticia; García-España, Enrique
Source:
Chemical communications 2020 v.56 no.54 pp. 7511-7514
ISSN:
1364-548X
Subject:
superoxide dismutase,   etc   ; binding sites; chemical reactions; copper; enzyme activity; quantum mechanics; reaction mechanisms;     Show all 7 Subjects
Abstract:
... Quantum chemical and multiscale calculations reveal the mechanistic pathway of two superoxide dismutase mimetic N-alkylated tetra-azacyclophane copper complexes with remarkable activity. The arrangement of the binding site afforded by the bulky alkyl substituents and the coordinated water molecule as a proton source play key roles in the reaction mechanism. ...
DOI:
10.1039/d0cc01926g

13. Methionine augments endogenous antioxidant capacity of rice protein through stimulating MSR antioxidant system and activating Nrf2-ARE pathway in growing and adult rats

Author:
Li, Hui; Cai, Liang; Liang, Mingcai; Wang, Zhengxuan; Zhang, Yan; Wu, Qiong; Yang, Lin
Source:
European food research & technology 2020 v.246 no.5 pp. 1051-1063
ISSN:
1438-2377
Subject:
superoxide dismutase,   etc   ; adults; antioxidant activity; antioxidants; catalase; food research; glutathione; methionine; rats; rice protein;     Show all 10 Subjects
Abstract:
... To elucidate the influence of methionine on the endogenous antioxidant activity of rice protein (RP), growing and adult rats were fed with RP and methionine-supplemented RP (RM). After 2 weeks feeding, hepatic contents of ROS were significantly reduced by RP and RM. The endogenous antioxidant responses were induced by RP and increased by RM, in which methionine sulfoxide reductases (MsrA, MsrB2, M ...
DOI:
10.1007/s00217-020-03464-5

14. Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats

Author:
Wang, Zhengxuan; Cai, Liang; Li, Hui; Liang, Mingcai; Zhang, Yan; Wu, Qiong; Yang, Lin
Source:
Journal of food biochemistry 2020 v.44 no.5 pp. e13180
ISSN:
0145-8884
Subject:
superoxide dismutase,   etc   ; antioxidant activity; antioxidants; body weight; catalase; glutathione; males; methionine; oxidative stress; pellets; rice protein;     Show all 11 Subjects
Abstract:
... Methionine sulfoxide reductase (Msr) and glutathione (GSH) are two endogenous antioxidant systems for depressing oxidative stress. The aim of this study is to investigate the role of methionine in involving the stimulation of endogenous antioxidant capacity of rice protein (RP). Seven‐week‐old male Wistar rats (body weight 180–200 g) were fed with commercial pellets (as control), methionine, and R ...
DOI:
10.1111/jfbc.13180

15. Toxicity of glyphosate in feed for weanling piglets and the mechanism of glyphosate detoxification by the liver nuclear receptor CAR/PXR pathway

Author:
Fu, Huiyang; Qiu, Shengnan; Yao, Xinxin; Gao, Feng; Tan, Peng; Teng, Teng; Shi, Baoming
Source:
Journal of hazardous materials 2020 v.387 pp. 121707
ISSN:
0304-3894
Subject:
superoxide dismutase,   etc   ; P-glycoproteins; gene expression; genes; glutathione peroxidase; glyphosate; hydrogen peroxide; liver; piglets; toxicity; weanlings;     Show all 11 Subjects
Abstract:
... Glyphosate (GLP), the most widely used and productive pesticide worldwide, which safety and reliability gradually become a social concern. It is important to explore the toxic of GLP on the limitation level by governments on piglets and the potential role of hepatic CAR/PXR and Keap1-Nrf2 pathways in low levels of glyphosate detoxification. Compared with the control group, the production performan ...
DOI:
10.1016/j.jhazmat.2019.121707

16. Sonochemiluminescence Based on a Small, Cheap, and Low-Power USB Mesh-Type Piezoelectric Ultrasonic Transducer

Author:
Du, Fangxin; Ma, Xiangui; Yuan, Fan; Wang, Chao; Snizhko, Dmytro; Guan, Yiran; Xu, Guobao
Source:
Analytical chemistry 2020 v.92 no.7 pp. 4755-4759
ISSN:
1520-6882
Subject:
superoxide dismutase,   etc   ; ascorbic acid; chemiluminescence; detection limit; mobile telephones; reactive oxygen species; sonication; ultrasonic treatment; ultrasonics;     Show all 9 Subjects
Abstract:
... A small, cheap, and low-power mesh-type piezoelectric ultrasonic transducer (MPUT) from a household USB humidifier has been developed as a sonochemiluminescence generator for the first time. The ultrasonication of an MPUT facilitates the generation of reactive oxygen species to trigger sonochemiluminescence. There is no light emission of luminol without sonication. In contrast, the luminescence be ...
DOI:
10.1021/acs.analchem.0c00042

17. Doping Nitrogen into Q-Graphene by Plasma Treatment toward Peroxidase Mimics with Enhanced Catalysis

Author:
Li, Shuai; Zhao, Xiaoting; Gang, Ruotong; Cao, Bingqiang; Wang, Hua
Source:
Analytical chemistry 2020 v.92 no.7 pp. 5152-5157
ISSN:
1520-6882
Subject:
superoxide dismutase,   etc   ; ambient temperature; catalase; catalytic activity; colorimetry; hydrogen peroxide; hydrophilicity; milk; nitrogen; peroxidase;     Show all 10 Subjects
Abstract:
... A facile and efficient plasma treatment strategy has been applied for the first time to dope heteroatom nitrogen (N) into Q-graphene (QG) under ambient temperature toward a carbon-based green nanozyme. It was discovered that the resulting N doped QG (N-QG) nanozyme can present the greatly enhanced catalysis activity, which is nearly 5-fold higher than that of pristine QG, as comparably revealed by ...
DOI:
10.1021/acs.analchem.9b05645

18. Biological Activity of the Supramolecular Complex of Glycyrrhizic and Salicylic Acids

Author:
Babaeva, D. T.; Esanov, R. S.; Akhunov, A. A.; Gafurov, M. B.; Khashimova, N. R.; Matchanov, A. D.
Source:
Chemistry of natural compounds 2020 v.56 no.2 pp. 278-281
ISSN:
0009-3130
Subject:
superoxide dismutase,   etc   ; bioactive properties; catalase; chlorides; cotton; glycyrrhizin; growth and development; models; peroxidase; salicylic acid; salinity;     Show all 11 Subjects
Abstract:
... Supramolecular complexes of glycyrrhizic acid (GA) and salicylic acid (SA) in various mole ratios of 1:1, 2:1, 4:1, and 8:1 were prepared for the first time. Their IR and UV spectra indicated that a complex with SA did form. The supramolecular complex with a 2:1 ratio, which was called DAG-1, had the optimal molecular ratio of GA and SA for high biological activity. DAG-1 at a concentration of 10– ...
DOI:
10.1007/s10600-020-03006-1

19. Non-specific immune factors differences in coelomic fluid from polian vesicle and coelom of Apostichopus japonicus, and their early response after evisceration

Author:
Ren, Yuan; Zhang, Jialin; Wang, Yinan; Chen, Jing; Liang, Chunlei; Li, Ruijun; Li, Qiang
Source:
Fish & shellfish immunology 2020 v.98 pp. 160-166
ISSN:
1050-4648
Subject:
superoxide dismutase,   etc   ; Apostichopus japonicus; animals; catalase; coelomocytes; enzyme activity; evisceration; genes; immune response; immunocompetence; nutrients; tissues;     Show all 12 Subjects
Abstract:
... Coelomic fluid contains a population of coelomocytes, enzymes, nutrients and kinds of molecules that could be essential for Apostichopus japonicus live. The coelom and polian vesicle are the main tissues that hold the most coelomic fluid in the animal, but whether there exists any immunological difference of the coelomic fluid from the two tissues remains unknown. In this study, we first extracted ...
DOI:
10.1016/j.fsi.2019.12.094

20. Physiological and biochemical responses of different shell color strains of Manila clam to low salinity challenges

Author:
Nie, Hongtao; Jahan, Kifat; Zhang, Wenlong; Huo, Zhongming; Yan, Xiwu
Source:
Aquaculture reports 2020 v.16 pp. 100260
ISSN:
2352-5134
Subject:
superoxide dismutase,   etc   ; Ruditapes philippinarum; alpha-amylase; aquaculture; biogeography; catalase; clams; enzyme activity; estuaries; reproduction; salinity; zebras;     Show all 12 Subjects
Abstract:
... Salinity is one of the important factors affecting geographic distribution, reproduction and physiological processes of marine and estuarine organisms. In this study, the effects of different salinity on the physiological and biochemical response were evaluated in three shell color strains and wild population of Ruditapes philippinarum by measuring superoxide dismutase (SOD), catalase (CAT), and α ...
DOI:
10.1016/j.aqrep.2019.100260