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1. Chemical transformation and cytotoxicity of iron oxide nanoparticles (IONPs) accumulated in mitochondria

Author:
Lifo Ruan; Haijing Li; Jiayu Zhang; Mengxue Zhou; Hui Huang; Juncai Dong; Jinxia Li; Feng Zhao; Zhonghua Wu; Jun Chen; Zhifang Chai; Yi Hu
Source:
Talanta 2023 v.251 pp. 123770
ISSN:
0039-9140
Subject:
toxicity testing,   etc   ; X-ray absorption spectroscopy; biomedical research; cytotoxicity; iron oxides; lysosomes; mitochondria; mitochondrial membrane; oxidation;     Show all 9 Subjects
Abstract:
... Iron oxide nanoparticles (IONPs) have been widely used as a nanoscale tool in biomedical research. However, it remains largely unknown how IONPs are transformed at a subcellular level to elicit distinct biological effects. In the present study, we prepared three different IONPs, including two IONPs targeting mitochondria (IONP-TPP) and lysosomes (IONP-APM), respectively, and a control with no spec ...
DOI:
10.1016/j.talanta.2022.123770

2. Microbiological analysis, antimicrobial activity, heavy-metals content and physico-chemical properties of Fijian mud pool samples

Author:
Atanas Pipite; Galana Siro; Ramesh Subramani; Sathiyaraj Srinivasan
Source:
Science of the total environment 2023 v.854 pp. 158725
ISSN:
0048-9697
Subject:
genetic testing,   etc   ; Nocardia; Streptomyces; World Health Organization; antibacterial properties; antibiotics; environment; heavy metals; pH; risk; temperature; therapeutics; Fiji;     Show all 13 Subjects
Abstract:
... The hot springs are home to a rich bacterial diversity which could be the source of enzymes, antibiotics and many other commercially important products. Most of the hot springs present in Fiji are unexplored and their analysis of microbial diversity could be of great interest in facilitating various industrial, agricultural and medicinal applications. This study is an attempt to evaluate the heavy ...
DOI:
10.1016/j.scitotenv.2022.158725

3. An ultra-sensitive UHPLC-QqQ-MS/MS method for determination of 54 benzodiazepines (pharmaceutical drugs, NPS and metabolites) and z-drugs in biological samples

Author:
Olga Wachełko; Paweł Szpot; Kaja Tusiewicz; Karolina Nowak; Agnieszka Chłopaś-Konowałek; Marcin Zawadzki
Source:
Talanta 2023 v.251 pp. 123816
ISSN:
0039-9140
Subject:
toxicity testing,   etc   ; alcohols; anticonvulsants; anxiety; benzodiazepines; bile; blood; central nervous system; epilepsy; forensic sciences; illicit drugs; markets; medical treatment; metabolites; sedatives; sleep disorders; urine;     Show all 17 Subjects
Abstract:
... Benzodiazepines exhibit central nervous system depressive activity as well as sedative, hypnotic, and anticonvulsant properties, which enable to use them as medical treatment in anxiety, epilepsy, insomnia and alcohol withdrawal syndrome. However, from 2000s illegal benzodiazepine derivatives have started to emerge on illicit drug market as new psychoactive substances (NPSs) monitored in many coun ...
DOI:
10.1016/j.talanta.2022.123816

4. Glycerol-compressed self-assembly nanogel based on ovomucin and chito-oligosaccharide: A novel green strategy for curcumin delivery

Author:
Xuanchen Li; Chunfang Yin; Boyu Liu; Long Zou; Qi Xu; Chang Ming Li
Source:
Food hydrocolloids 2023 v.134 pp. 107996
ISSN:
0268-005X
Subject:
toxicity testing,   etc   ; antioxidant activity; bioavailability; cell viability; curcumin; encapsulation; fluorescence microscopy; glycerol; hydrocolloids; hydrodynamics; hydrogen bonding; hydrophobic bonding; hydrophobicity; nanogels; ovomucin; particle size distribution; toxicity;     Show all 17 Subjects
Abstract:
... Nano-gel technology has been one of the popular methods to solve the low bioavailability of hydrophobic active substances. In this work, Ovomucin (OVM) was combined with chito-oligosaccharide (COS) by self-assembly, followed by condensation of complexes initiated via glycerol solution to produce green nanogel delivering curcumin. The successful encapsulation of curcumin was confirmed by UV–Vis spe ...
DOI:
10.1016/j.foodhyd.2022.107996

5. Analgesic, anti-inflammatory activity and metabolite profiling of the methanolic extract of Callicarpa arborea Roxb. leaves

Author:
Rubaet Sharmin Ema; S.M. Neamul Kabir Zihad; Md Naharul Islam; Nazifa Sifat; Razina Rouf; Jamil A. Shilpi; Shaikh Jamal Uddin
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115757
ISSN:
0378-8741
Subject:
toxicity testing,   etc   ; Callicarpa; acetic acid; acute toxicity; albino; analgesic effect; analgesics; anti-inflammatory activity; chemical composition; dose response; edema; egg albumen; formalin test; gas chromatography-mass spectrometry; hot plate test; metabolites; mortality; pain; phytochemicals; rheumatoid arthritis; traditional medicine; tribal peoples; Bangladesh; India;     Show all 24 Subjects
Abstract:
... Callicarpa arborea Roxb. is widely used as traditional medicine especially by the tribal people of Bangladesh in the management of wide range of ailments. In addition to Bangladesh, the leaves of this plant is utilized as a remedy to various painful and inflammatory conditions including rheumatism, toothache and stomachache in other countries of Indian subcontinent. Depending on the ethnomedicinal ...
DOI:
10.1016/j.jep.2022.115757

6. 23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways

Author:
Chunyan Chen; Lin Li; Xiaomei Liu; Deqin Zhang; Yang Liu; Yuhong Li
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115725
ISSN:
0378-8741
Subject:
toxicity testing,   etc   ; Actaea cimicifuga; Oriental traditional medicine; Western blotting; blood serum; cytotoxicity; edema; enzyme-linked immunosorbent assay; eosin; fluorescent antibody technique; genes; glycosides; histopathology; interleukin-6; lipopolysaccharides; lung function; lungs; macrophages; models; nitric oxide; pharyngitis; phosphorylation; plethysmography; protein content; rhizomes; therapeutics; triterpenoids;     Show all 27 Subjects
Abstract:
... Cimicifuga foetida L. is a well-established traditional Chinese medicine with heat-clearing and detoxifying effects and has good therapeutic effect on oral mucosal ulcer and pharyngitis. The rhizome of this herb is rich in triterpenoid glycosides, including 23-O-acetylshengmanol-3-o-α-L-arabinoside (DA). Whether and how DA attenuates acute lung injury (ALI) are unclear. Accordingly, we focused on ...
DOI:
10.1016/j.jep.2022.115725

7. Antibacterial and anti-inflammatory activity of plant species used in traditional poultry ethnomedicine in Zimbabwe: A first step to developing alternatives to antibiotic poultry feed additives

Author:
P. Jambwa; S.M. Nkadimeng; T.N. Mudimba; G. Matope; L.J. McGaw
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115687
ISSN:
0378-8741
Subject:
toxicity testing,   etc   ; Adenia; Aloe greatheadii; Erythrina abyssinica; Escherichia coli; Euphorbia; Salmonella Enteritidis; Salmonella Gallinarum; Staphylococcus aureus; acetone; anti-inflammatory activity; antibacterial properties; antibiotics; antioxidant activity; antioxidants; ascorbic acid; colorimetry; cytotoxicity; free radicals; kidneys; methanol; monkeys; poultry; poultry feed; therapeutics; traditional medicine; Zimbabwe;     Show all 27 Subjects
Abstract:
... Global interest in phytogenic feed additives as alternatives to antibiotics in feed has been spurred by the banning of antibiotic growth promoters by several countries. Suitable plant extracts for development of phytogenic feed additives should have therapeutic value and should also be safe. The aim of this study was to evaluate the antibacterial, antioxidant and anti-lipoxygenase activities as we ...
DOI:
10.1016/j.jep.2022.115687

8. Relation entre EPA et DHA transportés par les lipoprotéines et caractéristiques carcinologiques mammaires

Author:
C. Bobin-Dubigeon; E.H. Nazih; M. Croyal; J.-M. Huvelin; D. Vansteene; J.-M. Bard
Source:
Nutrition clinique et métabolisme 2022 v.36 no.1 pp. S48
ISSN:
0985-0562
Subject:
testing,   etc   ; neoplasms; nutrition;     Show all 3 Subjects
Abstract:
... Plus de 10 % des cancers sont associés à une mauvaise alimentation, les AG notamment ω3 pouvant en influencer la sévérité. Or, l’effet des AG ω3, EPA et DHA, sur le cancer du sein, pourrait différer, selon les lipoprotéines qui les transportent et selon les caractéristiques tumorales. L’objectif de l’étude est de clarifier la relation entre EPA et DHA des lipoprotéines plasmatiques et les caractér ...
DOI:
10.1016/j.nupar.2021.12.093

9. A test for Kronecker Product Structure covariance matrix

Author:
Patrik Guggenberger; Frank Kleibergen; Sophocles Mavroeidis
Source:
Journal of econometrics 2022 pp. -
ISSN:
0304-4076
Subject:
product testing; testing,   etc   ; Monte Carlo method; econometrics; journals; variance covariance matrix; weight;     Show all 7 Subjects
Abstract:
... We propose a test for a covariance matrix to have Kronecker Product Structure (KPS). KPS implies a reduced rank restriction on a certain transformation of the covariance matrix and the new procedure is an adaptation of the Kleibergen and Paap (2006) reduced rank test. To derive the limiting distribution of the Wald type test statistic proves challenging partly because of the singularity of the cov ...
DOI:
10.1016/j.jeconom.2022.01.005

10. Impact d’un mauvais état nutritionnel sur la survie de patients atteints de la SLA

Author:
C. Schmitt; A. Pradignac
Source:
Nutrition clinique et métabolisme 2022 v.36 no.1 pp. S61
ISSN:
0985-0562
Subject:
testing,   etc   ; nutrition; patients;     Show all 3 Subjects
Abstract:
... La sclérose latérale amyotrophique (SLA) est une pathologie neurodégénérative rare, d’origine inconnue, de pronostic sévère, sans traitement étiologique. Sa prise en charge repose essentiellement sur un accompagnement pluridisciplinaire comprenant une prise en charge et un suivi nutritionnel régulier. L’objectif de cette étude a été d’évaluer les facteurs prédictifs, notamment nutritionnels, de l’ ...
DOI:
10.1016/j.nupar.2021.12.118

11. TT-Mars: structural variants assessment based on haplotype-resolved assemblies

Author:
Jianzhi Yang; Mark J.P. Chaisson
Source:
Genome biology 2022 v.23 no.1 pp. 110
ISSN:
1474-760X
Subject:
testing,   etc   ; genome; genome assembly;     Show all 3 Subjects
Abstract:
... Variant benchmarking is often performed by comparing a test callset to a gold standard set of variants. In repetitive regions of the genome, it may be difficult to establish what is the truth for a call, for example, when different alignment scoring metrics provide equally supported but different variant calls on the same data. Here, we provide an alternative approach, TT-Mars, that takes advantag ...
DOI:
10.1186/s13059-022-02666-2

12. Étude de la validité des équations d’impédancemétrie bioélectrique dans une population de plus de 2000 sujets obèses

Author:
M. Coëffier; M. El Machkouri; C. L’Huillier; V. Folope; H. Lelandais; S. Grigioni; P. Déchelotte; N. Achamrah
Source:
Nutrition clinique et métabolisme 2022 v.36 no.1 pp. S30
ISSN:
0985-0562
Subject:
testing,   etc   ; nutrition; patients; rayon;     Show all 4 Subjects
Abstract:
... L’étude de la composition corporelle est un élément important dans la prise en charge des patients obèses. L’impédancemétrie bioélectrique (BIA) est une technique simple et rapide mais sa validité au cours de l’obésité reste controversée. Nous avons donc évalué sur une large population de sujets obèses la validité des équations de BIA, en prenant pour référence l’absorptiométrie à rayons X ou DEXA ...
DOI:
10.1016/j.nupar.2021.12.056

13. Volatility of volatility: Estimation and tests based on noisy high frequency data with jumps

Author:
Yingying Li; Guangying Liu; Zhiyuan Zhang
Source:
Journal of econometrics 2022 v.229 no.2 pp. 422-451
ISSN:
0304-4076
Subject:
testing,   etc   ; econometrics; exhibitions; journals;     Show all 4 Subjects
Abstract:
... We establish a feasible central limit theorem with convergence rate n1/8 for the estimation of the integrated volatility of volatility (VoV) based on noisy high-frequency data with jumps. This is the first inference theory ever built for VoV estimation under such a general setup. The central limit theorem is applied to provide interval estimates of the VoV and conduct hypothesis tests. Furthermore ...
DOI:
10.1016/j.jeconom.2021.02.007

14. Étude du profil en acylcarnitines après séjour prolongé aux soins intensifs

Author:
A.-F. Rousseau; S. Schmitz; C. Colson; L. Farrauto; P. Minguet; E. Cavalier; B. Misset; F. Boemer
Source:
Nutrition clinique et métabolisme 2022 v.36 no.1 pp. S60
ISSN:
0985-0562
Subject:
testing,   etc   ; carnitine; nutrition; patients;     Show all 4 Subjects
Abstract:
... Un séjour prolongé aux soins intensifs (SI) expose au risque de déficience en carnitine (C0), pouvant si besoin être supplémentée. Par ailleurs, une dysfonction mitochondriale a été liée avec certaines séquelles du syndrome post-soins intensifs. Les acylcarnitines (AC), dérivés de C0, en sont des marqueurs métaboliques. Le but de cette étude rétrospective était de décrire le profile en AC des pati ...
DOI:
10.1016/j.nupar.2021.12.116

15. Testing equality of several distributions in separable metric spaces: A maximum mean discrepancy based approach

Author:
Jin-Ting Zhang; Jia Guo; Bu Zhou
Source:
Journal of econometrics 2022 pp. -
ISSN:
0304-4076
Subject:
testing,   etc   ; econometrics; journals; selection methods;     Show all 4 Subjects
Abstract:
... A new test for equal distributions of several high-dimensional samples in separable metric spaces, with its test statistic constructed based on maximum mean discrepancy, is proposed and studied. The asymptotic null and alternative distributions of the test statistic are established under some mild conditions. The new test is implemented via a three-cumulant matched chi-square approximation with th ...
DOI:
10.1016/j.jeconom.2022.03.007

16. Accelerating Global Deletion of the Abnormal Toxicity Test for vaccines and biologicals. Planning common next steps. A workshop Report

Author:
Laura Viviani; Kirsty Reid; Thierry Gastineau; Catherine Milne; Dean Smith; Robin Levis; Dianliang Lei; Mark van Ooij; Philippe Alexandre Gilbert; Joris Vandeputte; Jianxun Xie; Leena Madhuri; Shahjahan Shaid; Vaughn Kubiak; Rajinder Suri; Takuo Mizukami; Yoshihisa Shirasaki; Xiantang Li; Ying-Ying Zhou; Alla Trapkova; Sunil Goel; Jai Prakash; Amrullah Aninditio Subagio; Eniek Suwarni; Kyung Jin Jung; Gautam Sanyal; Pradip Das; Emmanuelle Coppens; David Wright; Zhechu Peng; Helle Northeved; Carmen Jungbäck; Tatiana Kirpitchenok; Lorenzo Del Pace; Borami Seo; Brinda Poojary; Antoniana Ottoni
Source:
Biologicals 2022 v.78 pp. 17-26
ISSN:
1045-1056
Subject:
toxicity testing,   etc   ; animals; safety assessment;     Show all 3 Subjects
Abstract:
... This online workshop Accelerating Global Deletion of the Abnormal Toxicity Test for vaccines and biologicals. Planning common next steps was organized on October 14th, 2021, by the Animal Free Safety Assessment Collaboration (AFSA), the Humane Society International (HSI), the European Federation of Pharmaceutical Industries and Associations (EFPIA), in collaboration with the International Alliance ...
DOI:
10.1016/j.biologicals.2022.06.003

17. Déterminants de la fonction musculaire chez les patientes souffrant de troubles alimentaires restrictifs

Author:
E. Gentes; N. Farigon; B. Pereira; M. Pouget; M. Miolanne; M. Picard; J. Kauffmann; Y. Boirie
Source:
Nutrition clinique et métabolisme 2022 v.36 no.1 pp. S25
ISSN:
0985-0562
Subject:
testing,   etc   ; exercise test; nutrition; patients;     Show all 4 Subjects
Abstract:
... Les patients souffrant de troubles des conduites alimentaires restrictifs (TCAr) sont exposés à un risque important de complications, notamment la survenue d’une dénutrition. La mesure de la fonction musculaire peut désormais indiquer la présence de cette complication. L’exploration de la fonction musculaire peut également être un bon outil d’acceptation de la prise de poids chez les patientes sou ...
DOI:
10.1016/j.nupar.2021.12.045

18. A New Method for a Shorter and Valid Assessment of Olfactory Threshold in Repeated Measurement Designs Based on the Sniffin’ Sticks Test

Author:
Sarah Beutler; Liliana R. Ladner; Thomas Hummel; Ilona Croy
Source:
Chemosensory perception 2022 v.15 no.1 pp. 26-34
ISSN:
1936-5802
Subject:
testing,   etc   ; experimental design; measurement; sampling;     Show all 4 Subjects
Abstract:
... INTRODUCTION: The Sniffin’ Sticks threshold test is widely used to assess olfactory threshold due to its high reliability and validity. Nevertheless, this test procedure is quite long with an average duration of 10 to 20 min. In study designs that require multiple olfactory threshold tests on short intervals, this could exhaust participants. To counteract this limitation, we developed the informed ...
DOI:
10.1007/s12078-021-09291-6

19. Prediction and outlier detection in classification problems

Author:
Leying Guan; Robert Tibshirani
Source:
Journal of the Royal Statistical Society 2022 v.84 no.2 pp. 524-546
ISSN:
1369-7412
Subject:
testing,   etc   ; algorithms; journals; prediction; sampling;     Show all 5 Subjects
Abstract:
... We consider the multi‐class classification problem when the training data and the out‐of‐sample test data may have different distributions and propose a method called BCOPS (balanced and conformal optimized prediction sets). BCOPS constructs a prediction set C(x) as a subset of class labels, possibly empty. It tries to optimize the out‐of‐sample performance, aiming to include the correct class and ...
DOI:
10.1111/rssb.12443

20. Resurgence during transitions from variable- to fixed-interval schedules

Author:
Christian P. Yensen; Tyler D. Nighbor; Jemma E. Cook; Anthony C. Oliver; Kennon A. Lattal
Source:
Behavioural processes 2022 v.195 pp. 104567
ISSN:
0376-6357
Subject:
testing,   etc   ; exhibitions; extinction; pecking; pigeons;     Show all 5 Subjects
Abstract:
... The effects of local periods of extinction on resurgence following transitions from variable-interval (VI) to fixed-interval (FI) schedules were studied using four pigeons exposed to a within-session resurgence procedure. Each session was divided into a Training (T) Alternative-Reinforcement (AR), and Resurgence Test (RT) phase. During the T phase, key pecking was reinforced under a VI 60-s schedu ...
DOI:
10.1016/j.beproc.2021.104567