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1. DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity

Author:
Ling Yang; Liping Jiang; Xiance Sun; Jing Li; Ningning Wang; Xiaofang Liu; Xiaofeng Yao; Cong Zhang; Haoyuan Deng; Shaopeng Wang; Guang Yang
Source:
Food and chemical toxicology 2022 v.164 pp. 113046
ISSN:
0278-6915
Subject:
testosterone,   etc   ; ferroptosis; lipids; phthalates; testes; toxicity; toxicology;     Show all 7 Subjects
Abstract:
... Exposure to Di (2-ethylhexyl) phthalate (DEHP) has been associated with toxic effects of the reproductive system. However, the exact mechanism remains to be elucidated. In this study we explored the testicular toxicity induced by DEHP, and the probable molecular mechanism in the process. In vivo, the results demonstrated that DEHP affected testosterone levels and blood-testosterone barrier (BTB) i ...
DOI:
10.1016/j.fct.2022.113046

2. Boosting effect of testosterone on GDNF expression in Sertoli cell line (TM4); comparison between TM3 cells-produced and exogenous testosterone

Author:
Himasadat Zaker; Mazdak Razi; Alireza Mahmoudian; Farhad Soltanalinejad
Source:
Gene 2022 v.812 pp. 146112
ISSN:
0378-1119
Subject:
testosterone,   etc   ; Sertoli cells; cell lines; coculture; genes; spermatogenesis;     Show all 6 Subjects
Abstract:
... The Glial cell-derived neurotrophic factor (Gdnf) and testosterone induce the spermatogonial stem cells (SSCs) self-renewal and spermatogenesis, respectively. In present study the stimulating role of testosterone on Sertoli cells to produce Gdnf, and the possible effect of Gdnf on Gfrα1 and c-RET expressions were investigated. The TM4 cells (line Sertoli cells) were co-cultured with [0.1, 0.2 and ...
DOI:
10.1016/j.gene.2021.146112

3. Effects of Eccentric vs. Concentric Sports on Blood Muscular Damage Markers in Male Professional Players

Author:
Alfredo Córdova-Martínez; Alberto Caballero-García; Hugo J. Bello; Daniel Perez-Valdecantos; Enrique Roche
Source:
Biology 2022 v.11 no.3 pp. -
ISSN:
2079-7737
Subject:
testosterone,   etc   ; cortisol; creatine kinase; exercise; males; muscles; myoglobin; sports;     Show all 8 Subjects
Abstract:
... Background: Repetitive eccentric contractions can lead to higher degree of damage compared to repetitive concentric contractions. However, this type of exercise does not reproduce the real situations during the season in competitive sport disciplines. Methods: We analyzed the pattern of muscle damage blood markers in male professionals from three disciplines: cycling (n = 18), mainly concentric, v ...
DOI:
10.3390/biology11030343

4. Rapid quantitative analysis of hormones in serum by multilayer paper spray MS: Free MS from HPLC

Author:
Tianhao Wu; Gongwei Sun; Mingying Ma; Xingyu Pan; Sichun Zhang; Xinrong Zhang
Source:
Talanta 2022 v.237 pp. 122900
ISSN:
0039-9140
Subject:
testosterone,   etc   ; androstenedione; androsterone; blood serum; metabolism; paper; quantitative analysis;     Show all 7 Subjects
Abstract:
... Developing rapid and reliable method for simultaneous hormones quantitation is of great significant because of important roles of hormones in metabolism. However, current methods are faced with problems of low throughput or complicated operation procedure to remove matrices from serum samples in routine clinical diagnosis. In the present work, a multilayer PS-MS method was developed for rapid and ...
DOI:
10.1016/j.talanta.2021.122900

5. Preliminary investigation of reproductive hormone profiles in the blacktip shark (Carcharhinus limbatus), a placental viviparous species, in southern Florida

Author:
Hannah J. Verkamp; Neil Hammerschlag; James Quinlan; Joseph A. Langan; James A. Sulikowski
Source:
Marine & freshwater research 2022 v.73 no.4 pp. 520-527
ISSN:
1323-1650
Subject:
testosterone,   etc   ; Carcharhinus limbatus; coasts; estradiol; females; freshwater; progesterone; research; Florida;     Show all 9 Subjects
Abstract:
... Accurate reproductive information is crucial for the effective management of sharks. Here, we used non-lethal methods to evaluate reproductive hormone profiles of blacktip sharks (Carcharhinus limbatus) off the coast of southern Florida (FL) as part of a preliminary investigation of this species’ reproductive patterns in the region. Circulating testosterone concentrations in males ranged fr ...
DOI:
10.1071/MF21235

6. Testicular effects of a postnatal GnRH antagonist in domestic cats

Author:
Mariela Grisolia-Romero; Marcela Faya; Cynthia Marchetti; Hanna Körber; Sandra Goericke-Pesch; Cristina Gobello
Source:
Acta veterinaria Hungarica 2022 v.70 no.1 pp. 44-50
ISSN:
1588-2705
Subject:
testosterone,   etc   ; antagonists; body weight; epithelium; histology; males; placebos; puberty; testes;     Show all 9 Subjects
Abstract:
... The aim of this study was to describe the histological effects of two high postnatal doses of the potent third-generation GnRH antagonist, acyline in the domestic cat testicle. Secondly, the physical, endocrine, and steroidogenic findings of this pharmaceutical protocol are also reported. Twelve postnatal littermate male kittens were administered acyline in a dose of 2.2 mg/100 g SC weekly for 2 w ...
DOI:
10.1556/004.2021.00052

7. Two-Stage Syntheses of Clionastatins A and B

Author:
Hao Cui; Yang Shen; Yanyu Chen; Ruifeng Wang; Haoxiang Wei; Pengfei Fu; Xin Lei; Haoxiang Wang; Ruihao Bi; Yandong Zhang
Source:
Journal of the American Chemical Society 2022 v.144 no.20 pp. 8938-8944
ISSN:
1520-5126
Subject:
testosterone,   etc   ; aromatization; catalytic activity; chlorination; chlorine; olefin; oxidation; photochemistry; stereoselectivity;     Show all 9 Subjects
Abstract:
... A concise and divergent synthesis of the polychlorinated marine steroids clionastatin A and B from inexpensive testosterone has been achieved through a unique two-stage chlorination–oxidation strategy. Key features of the two-stage synthesis include (1) conformationally controlled, highly stereoselective dichlorination at C1 and C2 and C4–OH-directed C19 oxygenation followed by a challenging neope ...
DOI:
10.1021/jacs.2c03872

8. Regulation of sex differences in risk-based decision making by gonadal hormones: Insights from rodent models

Author:
Caitlin A. Orsini; Leah M. Truckenbrod; Alexa-Rae Wheeler
Source:
Behavioural processes 2022 v.200 pp. 104663
ISSN:
0376-6357
Subject:
testosterone,   etc   ; amygdala; cognition; estradiol; gonads; prefrontal cortex; progesterone; risk; rodents; schizophrenia;     Show all 10 Subjects
Abstract:
... Men and women differ in their ability to evaluate options that vary in their rewards and the risks that are associated with these outcomes. Most studies have shown that women are more risk averse than men and that gonadal hormones significantly contribute to this sex difference. Gonadal hormones can influence risk-based decision making (i.e., risk taking) by modulating the neurobiological substrat ...
DOI:
10.1016/j.beproc.2022.104663

9. Assessment of THADA gene polymorphisms in a sample of Colombian women with polycystic ovary syndrome: A pilot study

Author:
Maria Camila Alarcón-Granados; Harold Moreno-Ortíz; Clara Inés Esteban-Pérez; Atilio Ferrebuz-Cardozo; Gloria Eugenia Camargo-Villalba; Maribel Forero-Castro
Source:
Heliyon 2022 v.8 no.6 pp. e09673
ISSN:
2405-8440
Subject:
testosterone,   etc   ; androstenedione; computer software; genes; haplotypes; linkage disequilibrium; polycystic ovary syndrome; risk;     Show all 8 Subjects
Abstract:
... Polycystic ovary syndrome (PCOS) is a multifactorial and polygenic endocrine-metabolic disorder in women of reproductive age. SNPs in the THADA gene have been identified as PCOS risk loci. In this study, we evaluated the frequency of five polymorphisms in a sample of Colombian women with PCOS, and their association with clinical and endocrine-metabolic parameters. Forty-nine women with PCOS and fo ...
DOI:
10.1016/j.heliyon.2022.e09673

10. Associations of Sex Steroids and Sex Hormone-Binding Globulin with Non-Alcoholic Fatty Liver Disease: A Population-Based Study and Meta-Analysis

Author:
Xiaofang Zhang; Yuchan Mou; Elif Aribas; Masoud Amiri; Jana Nano; Wichor M. Bramer; Maryam Kavousi; Robert J. de Knegt; Eralda Asllanaj; Mohsen Ghanbari
Source:
Genes 2022 v.13 no.6 pp. -
ISSN:
2073-4425
Subject:
testosterone,   etc   ; estradiol; fatty liver; meta-analysis; sex hormone-binding globulin; systematic review;     Show all 6 Subjects
Abstract:
... Background: Prior studies have reported inconsistent results or less well-explored associations between sex hormones and non-alcoholic fatty liver disease (NAFLD). Here, we aimed to investigate the associations of NAFLD with sex steroids and sex hormone-binding globulin (SHBG) in the population-based study and conduct a comprehensive systematic review and meta-analysis of all published observation ...
DOI:
10.3390/genes13060966

11. Melatonin inhibits testosterone synthesis in Roosters Leydig cells by regulating lipolysis of lipid droplets

Author:
Qingyu Zhu; Lewei Guo; Wen An; Zhuncheng Huang; Hongyu Liu; Jing Zhao; Wenfa Lu; Jun Wang
Source:
Theriogenology 2022 pp. -
ISSN:
0093-691X
Subject:
testosterone,   etc   ; animal reproduction; carboxylic ester hydrolases; cholesterol; droplets; forskolin; lipolysis; melatonin; triacylglycerols;     Show all 9 Subjects
Abstract:
... Leydig cells are important component of testis cells, which can synthesize testosterone with free cholesterol derived from lipid droplets (LDs). It is well known that melatonin could regulate synthesis of testosterone. However, it is still unclear whether melatonin participates in the synthesis of testosterone by regulating the lipolysis of LDs in Leydig cells. The purpose of this study was to elu ...
DOI:
10.1016/j.theriogenology.2022.06.016

12. Post‐castration prostatic involution: A morphometric and endocrine study of healthy canines and those with benign prostatic hyperplasia

Author:
Guillermo Cazzuli; Juan Pablo Damián; Estela Molina; Paula Pessina
Source:
Reproduction in domestic animals 2022 v.57 no.2 pp. 157-164
ISSN:
0936-6768
Subject:
testosterone,   etc   ; blood serum; body weight; castration; dogs; estradiol; hyperplasia; morphometry; reproduction; ultrasonics;     Show all 10 Subjects
Abstract:
... The objective of this study was to evaluate the effect of castration on dimensions of the prostate by B‐mode ultrasound for 90 days, as well as to evaluate changes in serum concentrations of testosterone and oestradiol in clinically healthy canines and those with benign prostatic hyperplasia (BPH). Three groups of animals were used: healthy canines castrated on day 0 (HCC, n = 8), canines with a d ...
DOI:
10.1111/rda.14036

13. Voratins A–C: Pyridinium Alkaloids from the Marine Dinoflagellate Effrenium voratum with Inhibitory Effects on Biomarkers for Benign Prostatic Hyperplasia

Author:
Hangy Lee; Seung Joo Moon; Yeong Du Yoo; Eun Ju Jeong; Jung-Rae Rho
Source:
Journal of natural products 2022 v.85 no.6 pp. 1495-1502
ISSN:
1520-6025
Subject:
testosterone,   etc   ; Miozoa; biomarkers; humans; hyperplasia; moieties; nuclear magnetic resonance spectroscopy; therapeutics; zwitterions;     Show all 9 Subjects
Abstract:
... Three voratin compounds (1–3) were isolated from the symbiotic marine dinoflagellate Effrenium voratum. The planar structures of 1–3 were determined by 1D and 2D NMR spectroscopy and HRESIMS, and the relative and absolute configurations were established using ROESY correlations, Mosher’s method, and quantum calculations. All of the compounds are zwitterionic and contain a dihydroindolizinium ring ...
DOI:
10.1021/acs.jnatprod.1c01190

14. Determination of testosterone in serum by magnetic molecularly imprinted polymer-coupled nano-ESI-MS

Author:
Mingying Ma; Tianhao Wu; Gongwei Sun; Sichun Zhang
Source:
Analytical biochemistry 2022 pp. 114719
ISSN:
0003-2697
Subject:
testosterone,   etc   ; biomarkers; blood serum; detection limit; magnetism; mass spectrometry; molecular imprinting; quantitative analysis;     Show all 8 Subjects
Abstract:
... Monitoring clinical biomarkers, such as testosterone in serum, is important for disease assessment. Due to the very low concentration of testosterone in serum, we have developed a new strategy for its enrichment in serum samples by magnetic molecularly imprinted polymers (MMIPs) technology and detection by nano-electrospray ionization mass spectrometry (Nano-ESI-MS). Testosterone was selectively e ...
DOI:
10.1016/j.ab.2022.114719

15. Inter-annual repeatability and age-dependent changes in plasma testosterone levels in a longitudinally monitored free-living passerine bird

Author:
Martin Těšický; Tereza Krajzingrová; Jiří Eliáš; Hana Velová; Jana Svobodová; Petra Bauerová; Tomáš Albrecht; Michal Vinkler
Source:
Oecologia 2022 v.198 no.1 pp. 53-66
ISSN:
0029-8549
Subject:
testosterone,   etc   ; Parus major; body weight; data collection; females; heterophils; males; plumage; resource allocation;     Show all 9 Subjects
Abstract:
... While seasonal trends in testosterone levels are known from cross-cohort studies, data on testosterone inter-annual individual repeatability in wild birds are rare. Also, our understanding of hormonal age-dependent changes in testosterone levels is limited. We assessed plasma testosterone levels in 105 samples originating from 49 repeatedly captured free-living great tits (Parus major) sampled dur ...
DOI:
10.1007/s00442-021-05077-5

16. Associations between body shape across the life course and adulthood concentrations of sex hormones in men and pre- and postmenopausal women: a multicohort study

Author:
Ya-Wen Chen; Dong Hang; Ane S. Kværner; Edward Giovannucci; Mingyang Song
Source:
British journal of nutrition 2022 v.127 no.7 pp. 1000-1009
ISSN:
1475-2662
Subject:
testosterone,   etc   ; adiposity; adulthood; blood; body weight; estradiol; nutrition; postmenopause; premenopause; regression analysis; weight gain;     Show all 11 Subjects
Abstract:
... The objective was to investigate associations between life-course adiposity and sex hormone concentrations: trajectory of adiposity from age 5 to 40 (premenopausal)/60 (postmenopausal women and men) in relation to levels of oestrone (E1), oestradiol (E2), sex hormone-binding globulins (SHBG), testosterone in 4801 premenopausal and 6019 postmenopausal women in the Nurses’ Health Study (NHS) and NHS ...
DOI:
10.1017/S0007114521001732

17. Inhibitory effect of androgens on white adipose tissue thermogenic capacity

Author:
Alejandro Ezequiel Harnichar; María Guillermina Zubiría; Alejandra Paula Giordano; Ignacio Miguel; María Amanda Rey; Eduardo Spinedi; Andrés Giovambattista
Source:
Molecular and cellular endocrinology 2022 v.543 pp. 111542
ISSN:
0303-7207
Subject:
testosterone,   etc   ; adipocytes; ambient temperature; androgen receptors; dihydrotestosterone; mitochondria; obesity; protein content; white adipose tissue;     Show all 9 Subjects
Abstract:
... White adipose tissue (WAT) browning has gained interest due to its impact in obesity. Here, we evaluated the effect of androgens on the Ucp1-dependent thermogenic process from inguinal (IAT) and retroperitoneal (RPAT) WAT. Surgically androgens depleted rats (ODX) showed basal thermogenic activation (room temperature) in both WAT depots, which expressed higher levels of Ucp1, Prdm16 and Pgc1a. WAT ...
DOI:
10.1016/j.mce.2021.111542

18. Leukemia inhibitory factor-receptor signalling negatively regulates gonadotrophin-stimulated testosterone production in mouse Leydig Cells

Author:
Michael Curley; Annalucia Darbey; Liza O'Donnell; Karen R. Kilcoyne; Kirsten Wilson; Will Mungall; Diane Rebourcet; Jingtao Guo; Rod T. Mitchell; Lee B. Smith
Source:
Molecular and cellular endocrinology 2022 v.544 pp. 111556
ISSN:
0303-7207
Subject:
testosterone,   etc   ; Adenoviridae; adults; alleles; biosynthesis; enzymes; leukemia; leukemia inhibitory factor; ligands; mice; models; steroidogenesis;     Show all 12 Subjects
Abstract:
... Testicular Leydig cells (LCs) are the principal source of circulating testosterone in males. LC steroidogenesis maintains sexual function, fertility and general health, and is influenced by various paracrine factors. The leukemia inhibitory factor receptor (LIFR) is expressed in the testis and activated by different ligands, including leukemia inhibitory factor (LIF), produced by peritubular myoid ...
DOI:
10.1016/j.mce.2022.111556

19. Protective effect of polysaccharides from Ostrea rivularis against reproductive injury via regulating autophagy induced by oxidative stress

Author:
Tian Yu; Xianying Ye; Fang Deng; Zhuoyue Song; Mengru Zhu; Yao Chen; Tao Liu; Shihui Liu; Shijie Li
Source:
International journal of biological macromolecules 2022 v.209 pp. 655-667
ISSN:
0141-8130
Subject:
testosterone,   etc   ; Ostrea; autophagy; cyclophosphamide; oxidative stress; polysaccharides; protective effect; spermatozoa; testes; transmission electron microscopy;     Show all 10 Subjects
Abstract:
... The objective of this study was to investigate the effect of polysaccharides from Ostrea rivularis (ORP) relieving reproductive damage by regulating autophagy. The results showed that ORP intervention could alleviate the pathological changes of the testis and alleviate oxidative stress which were caused by cyclophosphamide (CTX) in vivo, including improve sperm symptoms and rise testosterone level ...
DOI:
10.1016/j.ijbiomac.2022.04.053

20. Rat age-related benign prostate hyperplasia is concomitant with an increase in the secretion of low ramified α-glycosydic polysaccharides

Author:
L. Trujillo-Rojas; J.M. Fernández-Novell; O. Blanco-Prieto; B. Martí-Garcia; T. Rigau; M.M. Rivera del Álamo; J.E. Rodríguez-Gil
Source:
Theriogenology 2022 pp. -
ISSN:
0093-691X
Subject:
testosterone,   etc   ; alpha-amylase; animal reproduction; blood serum; glucose; hyperplasia; peptidase K; polysaccharides; rats; secretion;     Show all 10 Subjects
Abstract:
... This work analyzed the expression of prostate polysaccharides in rats with age-related benign prostatic hyperplasia (BPH) for a better understanding of the possible relationship between prostate polysaccharides secretion and BPH onset. For this, prostatic glands from 1 month-old, 3 months-old, 6 months-old and 12 months-old Sprague-Dawley rats were processed in order to identify their overall poly ...
DOI:
10.1016/j.theriogenology.2022.06.011