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1. Cutaneous and subcutaneous fungal infections: recent developments on host–fungus interactions

Author:
Ma, Yubo; Wang, Xiaowen; Li, Ruoyu
Source:
Current opinion in microbiology 2021 v.62 pp. 93-102
ISSN:
1369-5274
Subject:
therapeutics,   etc   ; etiology; pathogenesis;     Show all 3 Subjects
Abstract:
... The incidence of skin fungal infections is increasing at an alarming rate worldwide, presenting a major challenge to health professionals. Cutaneous and subcutaneous fungal infections are caused by pathogenic or opportunistic organisms varying from mold, yeasts, to dimorphic fungi. Recently, skin fungal have been increasingly reported and studied, giving rise to crucial breakthroughs in etiology a ...
DOI:
10.1016/j.mib.2021.05.005

2. Covalent organic framework-engineered polydopamine nanoplatform for multimodal imaging-guided tumor photothermal-chemotherapy

Author:
Gao, Peng; Wei, Ruyue; Liu, Xiaohan; Chen, Yuanyuan; Wu, Tong; Shi, Mingwan; Wang, Mengzhen; Li, Na; Tang, Bo
Source:
Chemical communications 2021 v.57 no.46 pp. 5646-5649
ISSN:
1364-548X
Subject:
therapeutics,   etc   ; drugs; neoplasms;     Show all 3 Subjects
Abstract:
... A covalent organic framework (COF)-engineered polydopamine core–shell nanoplatform (PDA@COF) was developed. The ultrasmall pores and abundant functional sites of the COF endowed the nanoplatform with enhanced drug loading capacity and diminished drug leakage effect. Multimodal imaging-guided photothermal chemo-synergistic tumor-targeted therapy was realized after rational functionalization. This w ...
DOI:
10.1039/d1cc00314c

3. Hutchinson-Gilford progeria syndrome: Rejuvenating old drugs to fight accelerated ageing

Author:
Guilbert, Solenn M.; Cardoso, Déborah; Lévy, Nicolas; Muchir, Antoine; Nissan, Xavier
Source:
Methods 2021 v.190 pp. 3-12
ISSN:
1046-2023
Subject:
therapeutics,   etc   ; drugs; genetic disorders;     Show all 3 Subjects
Abstract:
... What if the next generation of successful treatments was hidden in the current pharmacopoeia? Identifying new indications for existing drugs, also called the drug repurposing or drug rediscovery process, is a highly efficient and low-cost strategy. First reported almost a century ago, drug repurposing has emerged as a valuable therapeutic option for diseases that do not have specific treatments an ...
DOI:
10.1016/j.ymeth.2020.04.005

4. Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions

Author:
Cossar, Peter J.; Wolter, Madita; van Dijck, Lars; Valenti, Dario; Levy, Laura M.; Ottmann, Christian; Brunsveld, Luc
Source:
Journal of the American Chemical Society 2021 v.143 no.22 pp. 8454-8464
ISSN:
1520-5126
Subject:
therapeutics,   etc   ; lysine; stabilizers; tryptophan;     Show all 4 Subjects
Abstract:
... The stabilization of protein complexes has emerged as a promising modality, expanding the number of entry points for novel therapeutic intervention. Targeting proteins that mediate protein–protein interactions (PPIs), such as hub proteins, is equally challenging and rewarding as they offer an intervention platform for a variety of diseases, due to their large interactome. 14-3-3 hub proteins bind ...
DOI:
10.1021/jacs.1c03035

5. Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications

Author:
Senthilvelan, Annamalai; Vonderfecht, Tyson; Shanmugasundaram, Muthian; Pal, Indra; Potter, Jason; Kore, Anilkumar R.
Source:
Organic letters 2021 v.23 no.11 pp. 4133-4136
ISSN:
1523-7052
Subject:
therapeutics,   etc   ; moieties; molecular biology;     Show all 3 Subjects
Abstract:
... The synthesis of a new trinucleotide cap analogue containing a locked nucleic acid (LNA) moiety such as m⁷⁽ᴸᴺᴬ⁾G(5′)ppp(5′)AₘpG and its molecular biology applications are described. The most appealing feature is that this new cap analogue outperforms the standard trinucleotide cap m⁷G(5′)ppp(5′)AₘpG and the anti-reverse cap analogue m₂⁷,³′⁻ᴼG(5′)ppp(5′)G by a factor of 5 in terms of translational ...
DOI:
10.1021/acs.orglett.1c01037

6. The File Drawer Problem in Nanomedicine

Author:
Ashkarran, Ali Akbar; Swann, Jennifer; Hollis, Leah; Mahmoudi, Morteza
Source:
Trends in biotechnology 2021 v.39 no.5 pp. 425-427
ISSN:
0167-7799
Subject:
therapeutics,   etc   ; biotechnology; nanomedicine; stakeholders;     Show all 4 Subjects
Abstract:
... The role of the ‘file drawer’ problem in nanomedicine, which partly drives the current limited clinical success of therapeutic nanoparticles, has been poorly investigated. We propose an integrated functioning of all stakeholders as the only effective way to address the file drawer problem in an efficient and timely manner. ...
DOI:
10.1016/j.tibtech.2021.01.009

7. Programmable protein circuit design

Author:
Chen, Zibo; Elowitz, Michael B.
Source:
Cell 2021 v.184 no.9 pp. 2284-2301
ISSN:
0092-8674
Subject:
therapeutics,   etc   ; genes; synthetic biology;     Show all 3 Subjects
Abstract:
... A fundamental challenge in synthetic biology is to create molecular circuits that can program complex cellular functions. Because proteins can bind, cleave, and chemically modify one another and interface directly and rapidly with endogenous pathways, they could extend the capabilities of synthetic circuits beyond what is possible with gene regulation alone. However, the very diversity that makes ...
DOI:
10.1016/j.cell.2021.03.007

8. Efficient production of recombinant secretory IgA against Clostridium difficile toxins in CHO-K1 cells

Author:
Bhaskara, Venugopal; Leal, Maria Trinidad; Seigner, Jacqueline; Friedrich, Theresa; Kreidl, Emanuel; Gadermaier, Elisabeth; Tesarz, Manfred; Rogalli, Azra; Stangl, Laura; Wallwitz, Jacqueline; Hammel, Katharina; Rothbauer, Mario; Moll, Herwig; Ertl, Peter; Hahn, Rainer; Himmler, Gottfried; Bauer, Anton; Casanova, Emilio
Source:
Journal of biotechnology 2021 v.331 pp. 1-13
ISSN:
0168-1656
Subject:
therapeutics,   etc   ; Clostridium difficile; biotechnology;     Show all 3 Subjects
Abstract:
... Despite the essential role secretory IgAs play in the defense against pathogenic invasion and the proposed value of recombinant secretory IgAs as novel therapeutics, currently there are no IgA-based therapies in clinics. Secretory IgAs are complex molecules and the major bottleneck limiting their therapeutic potential is a reliable recombinant production system. In this report, we addressed this i ...
DOI:
10.1016/j.jbiotec.2021.02.013

9. A comprehensive review on Morchella importuna: cultivation aspects, phytochemistry, and other significant applications

Author:
Sambyal, Krishika; Singh, Rahul Vikram
Source:
Folia microbiologica 2021 v.66 no.2 pp. 147-157
ISSN:
0015-5632
Subject:
therapeutics,   etc   ; Morchella; plant biochemistry;     Show all 3 Subjects
Abstract:
... Morchella importuna is one of the most highly priced edible mushrooms and a rich source of bioactive substances with numerous beneficial medicinal properties. It has been artificially cultivated in the last few years but due to the unclear mechanism of its fruiting body formation, the stable production has not been achieved yet. This review aims to provide the detailed information about the curren ...
DOI:
10.1007/s12223-020-00849-7

10. A guide to: generation and design of nanobodies

Author:
Muyldermans, Serge
Source:
TheFEBS journal 2021 v.288 no.7 pp. 2084-2102
ISSN:
1742-464X
Subject:
therapeutics,   etc   ; Camelidae; antigens; microorganisms;     Show all 4 Subjects
Abstract:
... A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are produced recombinantly in micro‐organisms and employed as research tools or for diagnostic and therapeutic applications. They were – and still are – also named single‐domain antibodies (sdAbs) or variable domain of the ...
DOI:
10.1111/febs.15515

11. It’s what’s on the inside that counts: Techniques for investigating the uptake and recycling of nanoparticles and proteins in cells

Author:
FitzGerald, Laura I.; Johnston, Angus P.R.
Source:
Journal of colloid and interface science 2021 v.587 pp. 64-78
ISSN:
0021-9797
Subject:
therapeutics,   etc   ; endocytosis; nanomedicine;     Show all 3 Subjects
Abstract:
... Many applications of nanomedicines depend on the therapeutic gaining access to the interior of cells. As most proteins and nanoparticles are taken up by endocytosis, determining the properties of nanoparticles that govern uptake is essential. In this review, we examine the current approaches for measuring the cellular uptake of nanoparticles and proteins. We explore the techniques distinguishing m ...
DOI:
10.1016/j.jcis.2020.11.076

12. Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

Author:
Malpartida, Ana Belen; Williamson, Matthew; Narendra, Derek P.; Wade-Martins, Richard; Ryan, Brent J.
Source:
Trends in biochemical sciences 2021 v.46 no.4 pp. 329-343
ISSN:
0968-0004
Subject:
therapeutics,   etc   ; etiology; mitochondria; mitophagy;     Show all 4 Subjects
Abstract:
... Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson’s disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an initiator, propagator, or bystander remains undetermined. The discovery of the role of the PD familial genes PTEN-induced putative kinase 1 (PINK1) and parkin (PRKN) in mediating mitochondrial degradation (mitophagy) reaffirme ...
DOI:
10.1016/j.tibs.2020.11.007

13. Co-delivery of proteins and small molecule drugs for mitochondria-targeted combination therapy

Author:
Liew, Si Si; Zhou, Jia; Li, Lin; Yao, Shao Q.
Source:
Chemical communications 2021 v.57 no.26 pp. 3215-3218
ISSN:
1364-548X
Subject:
therapeutics,   etc   ; doxorubicin; nanocapsules; ribonucleases;     Show all 4 Subjects
Abstract:
... Herein, we report the first use of gluthathione (GSH)-responsive nanogel-based carriers for mitochondria-targeted delivery of functional proteins and antibodies. We further demonstrated the successful co-encapsulation of a protein and small molecule (RNase A/Doxorubicin) in dual-cargo nanocapsules for mitochondria-targeted combination therapy. ...
DOI:
10.1039/d0cc08020a

14. Leptomeningeal Carcinomatosis: A Clinical Dilemma in Neuroendocrine Neoplasms

Author:
Apostolidis, Leonidas; Schrader, Jörg; Jann, Henning; Rinke, Anja; Krug, Sebastian
Source:
Biology 2021 v.10 no.4
ISSN:
2079-7737
Subject:
therapeutics,   etc   ; brain; carcinoma; prognosis;     Show all 4 Subjects
Abstract:
... Central nervous system (CNS) involvement by paraneoplastic syndromes, brain metastases, or leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms (NEN) has only been described in individual case reports. We evaluated patients with LC in four neuroendocrine tumor (NET) centers (Halle/Saale, Hamburg, Heidelberg, and Marburg) and characterized them clinically. In the study, 17 p ...
DOI:
10.3390/biology10040277

15. Biology of Lymphedema

Author:
Brix, Bianca; Sery, Omar; Onorato, Alberto; Ure, Christian; Roessler, Andreas; Goswami, Nandu
Source:
Biology 2021 v.10 no.4
ISSN:
2079-7737
Subject:
therapeutics,   etc   ; hemodynamics; lymphatic system;     Show all 3 Subjects
Abstract:
... This narrative review portrays the lymphatic system, a poorly understood but important physiological system. While several reviews have been published that are related to the biology of the lymphatic system and lymphedema, the physiological alternations, which arise due to disturbances of this system, and during lymphedema therapy, are poorly understood and, consequently, not widely reported. We p ...
DOI:
10.3390/biology10040261

16. Cell Surface Engineering Using DNAzymes: Metal Ion Mediated Control of Cell–Cell Interactions

Author:
Qian, Ruo-Can; Zhou, Ze-Rui; Guo, Weijie; Wu, Yuting; Yang, Zhenglin; Lu, Yi
Source:
Journal of the American Chemical Society 2021 v.143 no.15 pp. 5737-5744
ISSN:
1520-5126
Subject:
therapeutics,   etc   ; DNA; metabolites;     Show all 3 Subjects
Abstract:
... Regulating cell–cell interactions and cell behaviors via cell surface engineering is of significance for biological research such as cell fate control and cell therapy. While extensive efforts have been made to induce cell–cell assembly via various cell surface modifications triggered by macromolecules or organic metabolites, controllable cell–cell interactions that include both assembly and disas ...
DOI:
10.1021/jacs.1c00060

17. DNA-Based Dynamic Mimicry of Membrane Proteins for Programming Adaptive Cellular Interactions

Author:
Li, Jin; Xun, Kanyu; Zheng, Liyan; Peng, Xueyu; Qiu, Liping; Tan, Weihong
Source:
Journal of the American Chemical Society 2021 v.143 no.12 pp. 4585-4592
ISSN:
1520-5126
Subject:
therapeutics,   etc   ; DNA; DNA assembly;     Show all 3 Subjects
Abstract:
... Cells sense and respond to the external environment, mainly through proteins presented on the membrane where their expression and conformation are dynamically regulated via intracellular programs. Here, we engineer a cell–surface nanoarchitecture that realizes molecular-recognition-initiated DNA assembly to mimic the dynamic behavior of membrane proteins, enabling the manipulation of cellular inte ...
DOI:
10.1021/jacs.0c11245

18. Hunting for Familial Parkinson’s Disease Mutations in the Post Genome Era

Author:
Bentley, Steven R.; Guella, Ilaria; Sherman, Holly E.; Neuendorf, Hannah M.; Sykes, Alex M.; Fowdar, Javed Y.; Silburn, Peter A.; Wood, Stephen A.; Farrer, Matthew J.; Mellick, George D.
Source:
Genes 2021 v.12 no.3
ISSN:
2073-4425
Subject:
therapeutics,   etc   ; elderly; heterozygosity; mutation;     Show all 4 Subjects
Abstract:
... Parkinson’s disease (PD) is typically sporadic; however, multi-incident families provide a powerful platform to discover novel genetic forms of disease. Their identification supports deciphering molecular processes leading to disease and may inform of new therapeutic targets. The LRRK2 p.G2019S mutation causes PD in 42.5–68% of carriers by the age of 80 years. We hypothesise similarly intermediate ...
DOI:
10.3390/genes12030430

19. An expanded universe of cancer targets

Author:
Hahn, William C.; Bader, Joel S.; Braun, Theodore P.; Califano, Andrea; Clemons, Paul A.; Druker, Brian J.; Ewald, Andrew J.; Fu, Haian; Jagu, Subhashini; Kemp, Christopher J.; Kim, William; Kuo, Calvin J.; McManus, Michael T.; B. Mills, Gordon; Mo, Xiulei; Sahni, Nidhi; Schreiber, Stuart L.; Talamas, Jessica A.; Tamayo, Pablo; Tyner, Jeffrey W.; Wagner, Bridget K.; Weiss, William A.; Gerhard, Daniela S.; Dancik, Vlado; Gill, Shubhroz; Hua, Bruce; Sharifnia, Tanaz; Viswanathan, Vasanthi; Zou, Yilong; Dela Cruz, Filemon; Kung, Andrew; Stockwell, Brent; Boehm, Jesse; Dempster, Josh; Manguso, Robert; Vazquez, Francisca; Cooper, Lee A.D.; Du, Yuhong; Ivanov, Andrey; Lonial, Sagar; Moreno, Carlos S.; Niu, Qiankun; Owonikoko, Taofeek; Ramalingam, Suresh; Reyna, Matthew; Zhou, Wei; Grandori, Carla; Shmulevich, Ilya; Swisher, Elizabeth; Cai, Jitong; Chan, Issac S.; Dunworth, Matthew; Ge, Yuchen; Georgess, Dan; Grasset, Eloïse M.; Henriet, Elodie; Knútsdóttir, Hildur; Lerner, Michael G.; Padmanaban, Veena; Perrone, Matthew C.; Suhail, Yasir; Tsehay, Yohannes; Warrier, Manisha; Morrow, Quin; Nechiporuk, Tamilla; Long, Nicola; Saultz, Jennifer; Kaempf, Andy; Minnier, Jessica; Tognon, Cristina E.; Kurtz, Stephen E.; Agarwal, Anupriya; Brown, Jordana; Watanabe-Smith, Kevin; Vu, Tania Q.; Jacob, Thomas; Yan, Yunqi; Robinson, Bridget; Lind, Evan F.; Kosaka, Yoko; Demir, Emek; Estabrook, Joseph; Grzadkowski, Michael; Nikolova, Olga; Chen, Ken; Deneen, Ben; Liang, Han; Bassik, Michael C.; Bhattacharya, Asmita; Brennan, Kevin; Curtis, Christina; Gevaert, Olivier; Ji, Hanlee P.; Karlsson, Kasper A.J.; Karagyozova, Kremena; Lo, Yuan-Hung; Liu, Katherine; Nakano, Michitaka; Sathe, Anuja; Smith, Amber R.; Spees, Kaitlyn; Wong, Wing Hing; Yuki, Kanako; Hangauer, Matt; Kaufman, Dan S.; Balmain, Allan; Bollam, Saumya R.; Chen, Wei-Ching; Fan, QiWen; Kersten, Kelly; Krummel, Matthew; Li, Yun Rose; Menard, Marie; Nasholm, Nicole; Schmidt, Christin; Serwas, Nina K.; Yoda, Hiroyuki; Ashworth, Alan; Bandyopadhyay, Sourav; Bivona, Trevor; Eades, Gabriel; Oberlin, Stefan; Tay, Neil; Wang, Yuhao; Weissman, Jonathan
Source:
Cell 2021 v.184 no.5 pp. 1142-1155
ISSN:
0092-8674
Subject:
therapeutics,   etc   ; genomics; neoplasms; oncogenes;     Show all 4 Subjects
Abstract:
... The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most ...
DOI:
10.1016/j.cell.2021.02.020

20. Foldamer-Based Potassium Channels with High Ion Selectivity and Transport Activity

Author:
Qi, Shuaiwei; Zhang, Chenyang; Yu, Hao; Zhang, Jing; Yan, Tengfei; Lin, Ze; Yang, Bing; Dong, Zeyuan
Source:
Journal of the American Chemical Society 2021 v.143 no.9 pp. 3284-3288
ISSN:
1520-5126
Subject:
therapeutics,   etc   ; humans; potassium;     Show all 3 Subjects
Abstract:
... Small molecules that independently perform natural channel-like functions show greatly potential in the treatment of human diseases. Taking advantage of aromatic helical scaffolds, we develop a kind of foldamer-based ion channels with lumen size varying from 3.8 to 2.3 Å through a sequence substitution strategy. Our results clearly elucidate the importance of channel size in ion transport selectiv ...
DOI:
10.1021/jacs.0c12128