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1. Assessment of risks, implications, and opportunities of waterborne neurotoxic pesticides

Author:
Delaram Dara; Andrei P. Drabovich
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 735-741
ISSN:
1001-0742
Subject:
therapeutics,   etc   ; bioaccumulation; biochemical compounds; biodegradation; bioremediation; chlorinated hydrocarbons; genetic engineering; humans; mice; nervous system; neurotoxicity; organophosphorus compounds; pyrethrins; synergism; viability; China;     Show all 16 Subjects
Abstract:
... Pesticides are a well-known family of chemicals that have contaminated water systems globally. Four common subfamilies of pesticides include organochlorines, organophosphates, pyrethroids, and carbamate insecticides which have been shown to adversely affect the human nervous system. Studies have shown a link between pesticide exposure and decreased viability, proliferation, migration, and differen ...
DOI:
10.1016/j.jes.2022.03.033

2. Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo

Author:
Jixuan Ma; Yujia Xie; Yiju Xu; Pei Gu; Yingdie Zhang; Lieyang Fan; Yun Zhou; Haijiao Wang; Ting Zhou; Jintong He; Dongming Wang; Weihong Chen
Source:
Journal of environmental sciences (China) 2023 v.126 pp. 772-783
ISSN:
1001-0742
Subject:
therapeutics,   etc   ; antibodies; collagen; environmental exposure; epithelium; fibroblasts; fibrosis; gelatinase A; glycoproteins; inflammation; interleukin-11; interleukin-6; lungs; mice; mitogen-activated protein kinase; necrosis; neoplasms; neutralization; silica; China;     Show all 20 Subjects
Abstract:
... Environmental exposure to crystalline silica particles can lead to silicosis, which is one of the most serious pulmonary interstitial fibrosis around the world. Unfortunately, the exact mechanism on silicosis is unclear, and the effective treatments are lacking to date. In this study, we aim to explore the molecular mechanism by which interleukin-11 (IL-11) affects silica particles-induced lung in ...
DOI:
10.1016/j.jes.2022.03.015

3. An ultrasound activated cyanine-rhenium(i) complex for sonodynamic and gas synergistic therapy

Author:
Jiayi Zhu; Ai Ouyang; Jiaqi He; Juan Xie; Samya Banerjee; Qianling Zhang; Pingyu Zhang
Source:
Chemical communications 2022 v.58 no.20 pp. 3314-3317
ISSN:
1364-548X
Subject:
therapeutics,   etc   ; ferroptosis; ultrasonics;     Show all 3 Subjects
Abstract:
... A novel cyanine-rhenium(i) tricarbonyl complex is developed as a potent sonosensitizer and sono-activatable CO-releasing agent for synergistic sonodynamic therapy and CO gas therapy of cancer. The complex induced ferroptosis as the mode of cell death. ...
DOI:
10.1039/d1cc06769a

4. Engineering of a protein probe with multiple inputs and multiple outputs for evaluation of alpha synuclein aggregation states

Author:
Edward Chau; Jin Ryoun Kim
Source:
Biochemical engineering journal 2022 v.178 pp. 108292
ISSN:
1369-703X
Subject:
therapeutics,   etc   ; fluorescence; phosphine;     Show all 3 Subjects
Abstract:
... The aggregation of α-synuclein (αS) into oligomers and fibrils is implicated in the pathology of Parkinson’s Disease (PD). While a molecular probe for rapid and comprehensive evaluation of αS aggregation states is critical for a better understanding of PD pathology, identification of therapeutic candidates, and the development of early diagnostic strategies, no such probe has yet to be developed. ...
DOI:
10.1016/j.bej.2021.108292

5. Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy

Author:
Su Yeon Lee; Emma Grace Loll; Abd-Elrahman Said Hassan; Mingyu Cheng; Aijun Wang; Diana Lee Farmer
Source:
Journal of developmental biology 2022 v.10 no.1 pp. -
ISSN:
2221-3759
Subject:
therapeutics,   etc   ; genes; pathogenesis;     Show all 3 Subjects
Abstract:
... Lymphatic malformations are fluid-filled congenital defects of lymphatic channels occurring in 1 in 6000 to 16,000 patients. There are various types, and they often exist in conjunction with other congenital anomalies and vascular malformations. Great strides have been made in understanding these malformations in recent years. This review summarize known molecular and embryological precursors for ...
DOI:
10.3390/jdb10010011

6. Lacticaseibacillus rhamnosus: A Suitable Candidate for the Construction of Novel Bioengineered Probiotic Strains for Targeted Pathogen Control

Author:
Moloko G. Mathipa-Mdakane; Mapitsi S. Thantsha
Source:
Foods 2022 v.11 no.6 pp. -
ISSN:
2304-8158
Subject:
therapeutics,   etc   ; genes; probiotics;     Show all 3 Subjects
Abstract:
... Probiotics, with their associated beneficial effects, have gained popularity for the control of foodborne pathogens. Various sources are explored with the intent to isolate novel robust probiotic strains with a broad range of health benefits due to, among other mechanisms, the production of an array of antimicrobial compounds. One of the shortcomings of these wild-type probiotics is their non-spec ...
DOI:
10.3390/foods11060785

7. Large-scale fabrication of flexible EPDM/MXene/PW phase change composites with excellent light-to-thermal conversion efficiency via water-assisted melt blending

Author:
Hao Wu; Xinpeng Hu; Xiaolong Li; Mengjie Sheng; Xinxin Sheng; Xiang Lu; Jinping Qu
Source:
Composites 2022 v.152 pp. 106713
ISSN:
1359-835X
Subject:
therapeutics,   etc   ; enthalpy; nanosheets;     Show all 3 Subjects
Abstract:
... Thermal therapy based on phase change materials (PCMs) has broad application prospects in the field of personal thermal care. Herein, a serious of EPDM/MXene/PW (EMP) based shape-stable phase change composites (SSPCCs) with excellent flexibility was prepared in large scale via water-assisted melt blending. The MXene nanosheets were dispersed well in the EPDM matrix during the melt blending process ...
DOI:
10.1016/j.compositesa.2021.106713

8. Overcoming challenges in extracting prescribing habits from veterinary clinics using big data and deep learning

Author:
B Hur; LY Hardefeldt; K Verspoor; T Baldwin; JR Gilkerson
Source:
Australian veterinary journal 2022 v.100 no.5 pp. 220-222
ISSN:
0005-0423
Subject:
therapeutics,   etc   ; pets; Australia;     Show all 3 Subjects
Abstract:
... Understanding antimicrobial usage patterns and encouraging appropriate antimicrobial usage is a critical component of antimicrobial stewardship. Studies using VetCompass Australia and Natural Language Processing (NLP) have demonstrated antimicrobial usage patterns in companion animal practices across Australia. Doing so has highlighted the many obstacles and barriers to the task of converting raw ...
DOI:
10.1111/avj.13145

9. Pigment epithelium-derived factor and its role in microvascular-related diseases

Author:
Yuzhuo Wang; Xiucheng Liu; Xiaoyu Quan; Xichun Qin; Yeqing Zhou; Zhiwei Liu; Zhixiang Chao; Caili Jia; Hao Qin; Hao Zhang
Source:
Biochimie 2022 v.200 pp. 153-171
ISSN:
0300-9084
Subject:
therapeutics,   etc   ; angiogenesis; blood;     Show all 3 Subjects
Abstract:
... Microvascular diseases are among the most clinically important diseases, and vascular abnormalities are central in the development of such diseases. Pigment epithelium-derived factor (PEDF), a potent inhibitor of angiogenesis, exerts antiangiogenic effects without affecting the structure and function of normal blood vessels. PEDF also has neurotrophic effects, which may be a potential direction fo ...
DOI:
10.1016/j.biochi.2022.05.019

10. Testing drug release from medicated contact lenses: The missing link to predict in vivo performance

Author:
Ana F. Pereira-da-Mota; Chau-Minh Phan; Angel Concheiro; Lyndon Jones; Carmen Alvarez-Lorenzo
Source:
Journal of controlled release 2022 v.343 pp. 672-702
ISSN:
0168-3659
Subject:
therapeutics,   etc   ; drugs; eyes;     Show all 3 Subjects
Abstract:
... Contact lenses (CLs) offer a wide variety of advantages as ocular drug-releasing platforms, but the feasibility of medicated CL development is constrained by numerous scientific, technological, and regulatory challenges. One main difficulty is the setting of release rate specifications for each drug, since at present there are no standardized in vitro release models that can appropriately predict ...
DOI:
10.1016/j.jconrel.2022.02.014

11. Uncovering viral RNA–host cell interactions on a proteome-wide scale

Author:
Louisa Iselin; Natasha Palmalux; Wael Kamel; Peter Simmonds; Shabaz Mohammed; Alfredo Castello
Source:
Trends in biochemical sciences 2022 v.47 no.1 pp. 23-38
ISSN:
0968-0004
Subject:
therapeutics,   etc   ; RNA; ribonucleoproteins;     Show all 3 Subjects
Abstract:
... RNA viruses interact with a wide range of cellular RNA-binding proteins (RBPs) during their life cycle. The prevalence of these host–virus interactions has been highlighted by new methods that elucidate the composition of viral ribonucleoproteins (vRNPs). Applied to 11 viruses so far, these approaches have revealed hundreds of cellular RBPs that interact with viral (v)RNA in infected cells. Howeve ...
DOI:
10.1016/j.tibs.2021.08.002

12. Anticoagulant profile of subcutaneous enoxaparin in healthy dogs

Author:
Julianna Frum; Katie Havill; Caroline Andrews; Cory Langston; Marjory B. Brooks; Todd Archer; Andrew Mackin; John Thomason
Source:
Journal of veterinary pharmacology and therapeutics 2022 v.45 no.1 pp. 34-45
ISSN:
0140-7783
Subject:
therapeutics,   etc   ; anticoagulants; enoxaparin; pharmacokinetics;     Show all 4 Subjects
Abstract:
... Our study objective was to identify a subcutaneous enoxaparin dosage that provided a consistent anticoagulant intensity in dogs. Our hypotheses were that a dose of 0.8 mg/kg would provide inconsistent anticoagulation, a higher dose would provide consistent anticoagulation over a greater duration of time, and viscoelastometry would effectively monitor the anticoagulant status. Six healthy dogs rece ...
DOI:
10.1111/jvp.13015

13. Chaperoning shape-shifting tau in disease

Author:
Bryan D. Ryder; Pawel M. Wydorski; Zhiqiang Hou; Lukasz A. Joachimiak
Source:
Trends in biochemical sciences 2022 v.47 no.4 pp. 301-313
ISSN:
0968-0004
Subject:
therapeutics,   etc   ; amyloid; humans; models;     Show all 4 Subjects
Abstract:
... Many neurodegenerative diseases, including Alzheimer’s, originate from the conversion of proteins into pathogenic conformations. The microtubule-associated protein tau converts into β-sheet-rich amyloid conformations, which underlie pathology in over 25 related tauopathies. Structural studies of tau amyloid fibrils isolated from human tauopathy tissues have revealed that tau adopts diverse structu ...
DOI:
10.1016/j.tibs.2021.12.009

14. Determination of RNA-ligand interactions with the photoaffinity platform PEARL-seq

Author:
Alec N. Sexton; Lee E. Vandivier; Jennifer C. Petter; Herschel Mukherjee; J. Craig Blain
Source:
Methods 2022 pp. -
ISSN:
1046-2023
Subject:
therapeutics,   etc   ; RNA; crosslinking; ligands;     Show all 4 Subjects
Abstract:
... In the development of therapeutics, it is important to establish engagement of a compound to its intended target and identify other targets it binds to. Methods for demonstrating target engagement in the growing field of RNA-targeted therapeutics are therefore needed. We present a detailed protocol for Photoaffinity Evaluation of RNA Ligation-Sequencing (PEARL-seq), a platform for determining inte ...
DOI:
10.1016/j.ymeth.2022.06.009

15. Engineering the niche to differentiate and deploy cardiovascular cells

Author:
Gisselle Gonzalez; Alyssa R Holman; Aileena C Nelson; Adam J Engler
Source:
Current opinion in biotechnology 2022 v.74 pp. 122-128
ISSN:
0958-1669
Subject:
therapeutics,   etc   ; biotechnology; heart; myocytes;     Show all 4 Subjects
Abstract:
... Applications for stem cells have ranged from therapeutic interventions to more conventional screening and in vitro modeling, but significant limitations to each is due to the lack of maturity from decades old monolayer protocols. While those methods remain the ‘gold standard,’ newer three-dimensional methods, when combined with engineered niche, stand to significantly improve cell maturity and ena ...
DOI:
10.1016/j.copbio.2021.11.003

16. Evaluation of Bacteria and Fungi DNA Abundance in Human Tissues

Author:
Gabriela E. de Albuquerque; Bruno S. Moda; Marianna S. Serpa; Gabriela P. Branco; Alexandre Defelicibus; Isabella K. T. M. Takenaka; Maria G. de Amorim; Elizabeth C. Miola; Valquiria C. A. Martins; Katia L. Torres; Stephania M. Bezerra; Laura C. L. Claro; Adriane G. Pelosof; Claudia Z. Sztokfisz; Lais L. S. Abrantes; Felipe J. F. Coimbra; Luiz P. Kowalski; Fábio A. Alves; Stênio C. Zequi; Klas I. Udekwu; Israel T. Silva; Diana N. Nunes; Thais F. Bartelli; Emmanuel Dias-Neto
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
therapeutics,   etc   ; DNA; humans; saliva;     Show all 4 Subjects
Abstract:
... Whereas targeted and shotgun sequencing approaches are both powerful in allowing the study of tissue-associated microbiota, the human: microorganism abundance ratios in tissues of interest will ultimately determine the most suitable sequencing approach. In addition, it is possible that the knowledge of the relative abundance of bacteria and fungi during a treatment course or in pathological condit ...
DOI:
10.3390/genes13020237

17. Exploiting phage-derived carbohydrate depolymerases for combating infectious diseases

Author:
Hugo Oliveira; Zuzanna Drulis-Kawa; Joana Azeredo
Source:
Trends in microbiology 2022 pp. -
ISSN:
0966-842X
Subject:
therapeutics,   etc   ; carbohydrates; immune system;     Show all 3 Subjects
Abstract:
... Bacteria are protected against the immune system of their human hosts, as well as against predators such as phages, by expressing diverse surface carbohydrates. Some phages produce specialized depolymerases which can degrade those carbohydrates. Here, we discuss the biological role of depolymerases and how they can be exploited to develop new therapeutic strategies against pathogens. ...
DOI:
10.1016/j.tim.2022.05.002

18. JAFFAL: detecting fusion genes with long-read transcriptome sequencing

Author:
Nadia M. Davidson; Ying Chen; Teresa Sadras; Georgina L. Ryland; Piers Blombery; Paul G. Ekert; Jonathan Göke; Alicia Oshlack
Source:
Genome biology 2022 v.23 no.1 pp. 10
ISSN:
1474-760X
Subject:
therapeutics,   etc   ; nanopores; patients; transcriptome;     Show all 4 Subjects
Abstract:
... In cancer, fusions are important diagnostic markers and targets for therapy. Long-read transcriptome sequencing allows the discovery of fusions with their full-length isoform structure. However, due to higher sequencing error rates, fusion finding algorithms designed for short reads do not work. Here we present JAFFAL, to identify fusions from long-read transcriptome sequencing. We validate JAFFAL ...
DOI:
10.1186/s13059-021-02588-5

19. On-site experience of a project to increase access to diagnosis and treatment of Chagas disease in high-risk endemic areas of Colombia

Author:
Rafael Herazo; Fernando Torres-Torres; Claudia Amelia Gómez Mantilla; Lizeth Pérez Carillo; Andrés Cuervo; Manuel Alfonso Medina Camargo; John Flórez Moreno; Colin Forsyth; Mauricio Javier Vera; Ricardo Andrés Caicedo Díaz; Andrea Marchiol
Source:
Acta tropica 2022 v.226 pp. 106219
ISSN:
0001-706X
Subject:
therapeutics,   etc   ; Chagas disease; Colombia;     Show all 3 Subjects
Abstract:
... Colombia has one of the largest burdens of Chagas disease globally, with about 438,000 people affected according to 2015 estimates. Despite this, < 1% of the population has had access to diagnosis and treatment. A patient-centered roadmap for Chagas disease was developed from 2015 onwards to address access barriers and increase diagnostic and therapeutic coverage and was implemented in five munici ...
DOI:
10.1016/j.actatropica.2021.106219

20. Targeted mitochondrial delivery: A therapeutic new era for disease treatment

Author:
Ting Huang; Tianyuan Zhang; Jianqing Gao
Source:
Journal of controlled release 2022 v.343 pp. 89-106
ISSN:
0168-3659
Subject:
therapeutics,   etc   ; energy; mitochondria; pathogenesis;     Show all 4 Subjects
Abstract:
... As the major energy supplier in cells, mitochondria play a significant role in regulating cellular processes. The pathogenesis of various diseases is found to be associated with dysfunctional mitochondria, and supplement of functional mitochondria has been regarded as a potential therapeutic strategy. To achieve mitochondrial replenishment, transplantation of isolated mitochondria or utilization o ...
DOI:
10.1016/j.jconrel.2022.01.025