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1. FDA-Approved Antiparasitic Drugs in the 21st Century: A Success for Helminthiasis?

Author:
de Moraes, Josué; Geary, Timothy G.
Source:
Trends in parasitology 2020 v.36 no.7 pp. 573-575
ISSN:
1471-4922
Subject:
therapeutics,   etc   ; antiparasitic agents; helminthiasis;     Show all 3 Subjects
Abstract:
... Diseases caused by helminth infections affect more than a quarter of the population of the world, but the therapeutic arsenal is limited. The approval of moxidectin in 2018 and triclabendazole in 2019 by the FDA marked an important moment in the fight against diseases of poverty, such as helminthiases. ...
DOI:
10.1016/j.pt.2020.04.005

2. SnapShot: Cancer-Associated Fibroblasts

Author:
Park, Danielle; Sahai, Erik; Rullan, Antonio
Source:
Cell 2020 v.181 no.2 pp. 486
ISSN:
0092-8674
Subject:
therapeutics,   etc   ; fibroblasts; neoplasms;     Show all 3 Subjects
Abstract:
... Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment and have both tumor-promoting and tumor-suppressive functions. This SnapShot summarizes the origins of CAFs, their diverse functions, and how this relates to heterogeneity within the population. The suitability of targeting CAFs therapeutically is also discussed. ...
DOI:
10.1016/j.cell.2020.03.013

3. Hutchinson-Gilford progeria syndrome: Rejuvenating old drugs to fight accelerated ageing

Author:
Guilbert, Solenn M.; Cardoso, Déborah; Lévy, Nicolas; Muchir, Antoine; Nissan, Xavier
Source:
Methods 2020
ISSN:
1046-2023
Subject:
therapeutics,   etc   ; drugs; genetic disorders;     Show all 3 Subjects
Abstract:
... What if the next generation of successful treatments was hidden in the current pharmacopoeia? Identifying new indications for existing drugs, also called the drug repurposing or drug rediscovery process, is a highly efficient and low-cost strategy. First reported almost a century ago, drug repurposing has emerged as a valuable therapeutic option for diseases that do not have specific treatments an ...
DOI:
10.1016/j.ymeth.2020.04.005

4. Biclustering via sparse clustering

Author:
Helgeson, Erika S.; Liu, Qian; Chen, Guanhua; Kosorok, Michael R.; Bair, Eric
Source:
Biometrics 2020 v.76 no.1 pp. 348-358
ISSN:
0006-341X
Subject:
therapeutics,   etc   ; biometry; genes; patients;     Show all 4 Subjects
Abstract:
... In identifying subgroups of a heterogeneous disease or condition, it is often desirable to identify both the observations and the features which differ between subgroups. For instance, it may be that there is a subgroup of individuals with a certain disease who differ from the rest of the population based on the expression profile for only a subset of genes. Identifying the subgroup of patients an ...
DOI:
10.1111/biom.13136
PubMed:
31424089
PubMed Central:
PMC7028479

5. Strategies to Facilitate Translational Advances from Microbiome Surveys

Author:
Willis, Amy D.; Minot, Samuel S.
Source:
Trends in microbiology 2020 v.28 no.5 pp. 329-330
ISSN:
0966-842X
Subject:
therapeutics,   etc   ; human diseases; microbiome; surveys;     Show all 4 Subjects
Abstract:
... Manipulating the microbiome has enormous potential to treat important human diseases. Microbiome surveys are often used to identify potential therapeutic targets by finding associations between microbial elements and disease status. We argue that many reported associations between the microbiome and disease are incompatible with translational research because they are insufficiently specific. We e ...
DOI:
10.1016/j.tim.2020.02.002

6. Touching Base with Mechanical Pain

Author:
Arenas, Oscar M.; Lumpkin, Ellen A.
Source:
Cell 2020 v.180 no.5 pp. 824-826
ISSN:
0092-8674
Subject:
therapeutics,   etc   ; ion channels; mice; pain;     Show all 4 Subjects
Abstract:
... Unrelieved pain is a widespread condition that fuels the opioid crisis. Molecules that initiate painful sensations are intensively sought as therapeutic targets for improved pain interventions. In this issue of Cell, Beaulieu-Laroche et al. (2020) describe TACAN, a putative ion channel that mediates mechanical pain in mice. ...
DOI:
10.1016/j.cell.2020.02.022

7. Tea-polyphenol treated skin collagen owns coalesced adaptive-hydration, tensile strength and shape-memory property

Author:
Han, Yanting; Jiang, Yuanzhang; Hu, Jinlian
Source:
International journal of biological macromolecules 2020 v.158 pp. 1-8
ISSN:
0141-8130
Subject:
therapeutics,   etc   ; collagen; crosslinking; plasticizers; polyphenols; tensile strength;     Show all 6 Subjects
Abstract:
... Tea-polyphenol, as non-toxic skincare, even a therapeutic agent, was extensively studied from chemical, biological and physiological perspectives. This study reveals physical intelligences of a tea-polyphenol treated skin collagen (TP-treated SC) through a material-approach. Compared to untreated one, the TP-treated SC shows resistance to over-swelling and dehydration damage. There exists an infle ...
DOI:
10.1016/j.ijbiomac.2020.04.002

8. A model of post-traumatic stress symptoms on binge eating through emotion regulation difficulties and emotional eating

Author:
Echeverri-Alvarado, Brenda; Pickett, Scott; Gildner, Daniel
Source:
Appetite 2020 v.150 pp. 104659
ISSN:
0195-6663
Subject:
therapeutics,   etc   ; binging; eating disorders; models; United States;     Show all 5 Subjects
Abstract:
... Individuals who struggle with binge eating often report a history of trauma and post-traumatic stress symptoms (PTSS), but there is still a paucity of studies on the relationship between PTSS (as opposed to trauma exposure) and binge eating specifically. The current study aimed to contribute to a small body of literature surrounding the link between PTSS and binge eating. Binge eating may be a beh ...
DOI:
10.1016/j.appet.2020.104659

9. Small animal reproduction: Scientific facts versus dogmas or unverified beliefs

Author:
Fontbonne, Alain
Source:
Theriogenology 2020 v.150 pp. 464-470
ISSN:
0093-691X
Subject:
therapeutics,   etc   ; animal reproduction; case studies; dogs; veterinarians;     Show all 5 Subjects
Abstract:
... Small Animal Reproduction is a rather recent topic in the field of Animal Reproduction. Although some continuing educational societies aim to improve the level of general knowledge, published scientific facts are still limited, and there are many hypotheses or affirmations that remain unverified or even sometimes dogmatic or empirical. Through examples, this article reviews the main causes that ma ...
DOI:
10.1016/j.theriogenology.2020.03.014
PubMed:
32284211
PubMed Central:
PMC7102635

10. Engineered extracellular vesicles and their mimetics for clinical translation

Author:
Kim, Hyejin; Kim, Dajeong; Nam, Hyangsu; Moon, Sunghyun; Kwon, Young Jik; Lee, Jong Bum
Source:
Methods 2020 v.177 pp. 80-94
ISSN:
1046-2023
Subject:
therapeutics,   etc   ; cell communication; engineering; guidelines; homeostasis;     Show all 5 Subjects
Abstract:
... Cells secrete extracellular vesicles (EVs) to external environments to achieve cellular homeostasis and cell-to-cell communication. Their therapeutic potential has been constantly spotlighted since they mirror both cytoplasmic and membranous components of parental cells. Meanwhile, growing evidence suggests that EV engineering could further promote EVs with a maximized capacity. In this review, a ...
DOI:
10.1016/j.ymeth.2019.10.005

11. Methods for loading therapeutics into extracellular vesicles and generating extracellular vesicles mimetic-nanovesicles

Author:
Nasiri Kenari, Amirmohammad; Cheng, Lesley; Hill, Andrew F.
Source:
Methods 2020 v.177 pp. 103-113
ISSN:
1046-2023
Subject:
therapeutics,   etc   ; biochemical compounds; biomimetics; prokaryotic cells;     Show all 4 Subjects
Abstract:
... Extracellular vesicles (EVs) are membrane bound vesicles released into the extracellular environment by eukaryotic and prokaryotic cells. EVs are enriched in active biomolecules and they can horizontally transfer cargo to recipient cells. In recent years EVs have demonstrated promising clinical applications due to their theragnostic potential. Although EVs have promising therapeutic potential, the ...
DOI:
10.1016/j.ymeth.2020.01.001

12. Nucleic acid-cleaving catalytic DNA for sensing and therapeutics

Author:
Zimmermann, Alessandra C.; White, Ian M.; Kahn, Jason D.
Source:
Talanta 2020 v.211 pp. 120709
ISSN:
0039-9140
Subject:
therapeutics,   etc   ; DNA; catalytic activity; nucleotide sequences;     Show all 4 Subjects
Abstract:
... DNAzymes with nucleic acid-cleaving catalytic activity are increasing in versatility through concerted efforts to discover new sequences with unique functions, and they are generating excitement in the sensing community as cheap, stable, amplifiable detection elements. This review provides a comprehensive list and detailed descriptions of the DNAzymes identified to date, classified by their associ ...
DOI:
10.1016/j.talanta.2019.120709

13. Reprogramming extracellular vesicles with engineered proteins

Author:
Shi, Xiaojing; Cheng, Qinqin; Zhang, Yong
Source:
Methods 2020 v.177 pp. 95-102
ISSN:
1046-2023
Subject:
therapeutics,   etc   ; engineering; genetic engineering; neoplasms; proteins; surveys;     Show all 6 Subjects
Abstract:
... Extracellular vesicles (EVs) have been emerging as a new class of cell-free therapy for the treatment of a variety of diseases, including cancer, tissue injuries, and inflammatory diseases. Reprograming native EVs by genetic engineering and other approaches offers an attractive prospect of extending therapeutic capabilities of EVs beyond their natural functions and properties. In this review artic ...
DOI:
10.1016/j.ymeth.2019.09.017

14. Challenges in the management of anticoagulated patients with focal spasticity

Author:
Boulias, Chris; Ismail, Farooq; Phadke, Chetan P.
Source:
Toxicon 2020 v.177 pp. 93-95
ISSN:
0041-0101
Subject:
therapeutics,   etc   ; anticoagulants; botulinum toxin; hemorrhage; patients; warfarin;     Show all 6 Subjects
Abstract:
... In patients taking warfarin, the level of anticoagulation status using the International Normalized Ratio (INR) is one consideration before botulinum toxin type-A (BoNTA) injections; however, there is wide diversity in physician approaches and preferences in using INR status and the INR cut-off values to determine suitability of anticoagulated patients for BoNTA injections. There is no standard ap ...
DOI:
10.1016/j.toxicon.2020.01.011

15. Correction: An NIR-responsive mesoporous silica nanosystem for synergetic photothermal-immunoenhancement therapy of hepatocellular carcinoma

Author:
Yang‡, Han; Liu‡, Hong-sheng; Hou, Wen; Gao, Jun-xiao; Duan, Yue; Wei, Daohe; Gong, Xiao-qun; Wang, Han-jie; Wu, Xiao-li; Chang, Jin
Source:
Journal of materials chemistry B 2020 v.8 no.15 pp. 3150
ISSN:
2050-7518
Subject:
therapeutics,   etc   ; hepatoma; nanotechnology; porous media; silica;     Show all 5 Subjects
Abstract:
... Correction for ‘An NIR-responsive mesoporous silica nanosystem for synergetic photothermal-immunoenhancement therapy of hepatocellular carcinoma’ by Han Yang et al., J. Mater. Chem. B, 2020, 8, 251–259. ...
DOI:
10.1039/d0tb90040k

16. Targeting Strategies for Tissue-Specific Drug Delivery

Author:
Zhao, Zongmin; Ukidve, Anvay; Kim, Jayoung; Mitragotri, Samir
Source:
Cell 2020 v.181 no.1 pp. 151-167
ISSN:
0092-8674
Subject:
therapeutics,   etc   ; antibodies; drugs; nucleic acids; peptides; toxicity;     Show all 6 Subjects
Abstract:
... Off-target effects of systemically administered drugs have been a major hurdle in designing therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to enable site-specific drug delivery holds promise in reducing off-target effects, decreasing unwanted toxicities, and thereby enhancing a drug’s therapeutic efficacy. Over the past three decades, a large body of liter ...
DOI:
10.1016/j.cell.2020.02.001

17. N-Terminal Proteoforms in Human Disease

Author:
Bogaert, Annelies; Fernandez, Esperanza; Gevaert, Kris
Source:
Trends in biochemical sciences 2020 v.45 no.4 pp. 308-320
ISSN:
0968-0004
Subject:
therapeutics,   etc   ; alternative splicing; genes; human diseases; humans;     Show all 5 Subjects
Abstract:
... The collection of chemically different protein variants, or proteoforms, by far exceeds the number of protein-coding genes in the human genome. Major contributors are alternative splicing and protein modifications. In this review, we focus on those proteoforms that differ at their N termini with a molecular link to disease. We describe the main underlying mechanisms that give rise to such N-termin ...
DOI:
10.1016/j.tibs.2019.12.009

18. Phage Cocktail Therapy: Multiple Ways to Suppress Pathogenicity

Author:
Liu, Na; Lewis, Connor; Zheng, Wenming; Fu, Zheng Qing
Source:
Trends in plant science 2020 v.25 no.4 pp. 315-317
ISSN:
1360-1385
Subject:
therapeutics,   etc   ; bacterial wilt; pathogenicity; pathogens; phages; tomatoes;     Show all 6 Subjects
Abstract:
... Phage cocktails have emerged as precision tools for controlling plant bacterial diseases. Wang et al. now report that phage cocktails decreased the occurrence of tomato bacterial wilt disease efficiently by infecting and destroying bacterial pathogens, selecting phage-resistant but slow-growing pathogen strains, and fostering bacterial species that are antagonistic to the pathogens. ...
DOI:
10.1016/j.tplants.2020.01.013

19. Anti-degranulation response of herbal formula in RBL-2H3 cells

Author:
Hu, Jing; Chen, Yujuan; Zhu, Jiajing; Gao, Mingyan; Li, Jiani; Song, Zhengxun; Xu, Hongmei; Wang, Zuobin
Source:
Micron 2020 v.130 pp. 102819
ISSN:
0968-4328
Subject:
therapeutics,   etc   ; cytotoxicity; models; neoplasm cells; patients; rats;     Show all 6 Subjects
Abstract:
... Allergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical ...
DOI:
10.1016/j.micron.2019.102819

20. A review of emerging use of microcurrent therapy as a potential management option for stress in horses

Author:
Bryant, Madeleine Janet; Thirkell, Jack
Source:
Journal of veterinary behavior 2020 v.36 pp. 84-89
ISSN:
1558-7878
Subject:
therapeutics,   etc   ; breeding; horses; pain; tissue repair;     Show all 5 Subjects
Abstract:
... The use of microcurrent therapy (MCT), defined in this review as an alternating or direct current between <1 μA and 20 μA in equine therapy, is becoming more mainstream and well regarded. This review explores the application of MCT as an effective treatment for tissue injury and pain pathologies. As pain and stress have shown to be linked in recent research, the potential of MCT to mitigate stress ...
DOI:
10.1016/j.jveb.2020.02.002