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1. Explicating Exosomes: Reclassifying the Rising Stars of Intercellular Communication

Author:
Pluchino, Stefano; Smith, Jayden A.
Source:
Cell 2019 v.177 no.2 pp. 225-227
ISSN:
0092-8674
Subject:
therapeutics,   etc   ; cell communication; exosomes;     Show all 3 Subjects
Abstract:
... There is growing interest surrounding the diagnostic and therapeutic potential of exosomes, but a definitive description of these extracellular vesicles remains elusive. In this issue, Jeppesen et al. characterize exosomes following a strict isolation protocol and in so doing challenge several of the accepted properties of these agents of intercellular communication. ...
DOI:
10.1016/j.cell.2019.03.020

2. Addressing Reproducibility in Stem Cell and PRP Therapies

Author:
Anitua, Eduardo; Prado, Roberto
Source:
Trends in biotechnology 2019 v.37 no.4 pp. 340-344
ISSN:
0167-7799
Subject:
therapeutics,   etc   ; protocols; stem cells;     Show all 3 Subjects
Abstract:
... Stem cell and platelet-rich plasma (PRP) therapies are promising breakthroughs in the treatment of multiple conditions. However, the lack of reproducibility due to inaccurate reporting of the protocols used to obtain these biologics can hinder their therapeutic progress. A reporting guideline for biological therapies is required to address this issue. ...
DOI:
10.1016/j.tibtech.2018.11.010

3. Correction: From white to beige adipocytes: therapeutic potential of dietary molecules against obesity and their molecular mechanisms

Author:
Wang, Siyu; Pan, Min-Hsiung; Hung, Wei-Lun; Tung, Yen-Chen; Ho, Chi-Tang
Source:
Food & function 2019 v.10 no.3 pp. 1767
ISSN:
2042-650X
Subject:
therapeutics,   etc   ; adipocytes; obesity;     Show all 3 Subjects
Abstract:
... Correction for ‘From white to beige adipocytes: therapeutic potential of dietary molecules against obesity and their molecular mechanisms’ by Siyu Wang et al., Food Funct., 2019, DOI: 10.1039/c8fo02154f. ...
DOI:
10.1039/c9fo90006c

4. Structure Regulates Phage Lysis–Lysogeny Decisions

Author:
Trinh, Jimmy T.; Zeng, Lanying
Source:
Trends in microbiology 2019 v.27 no.1 pp. 3-4
ISSN:
0966-842X
Subject:
therapeutics,   etc   ; bacteriophages; cytolysis; lysogeny;     Show all 4 Subjects
Abstract:
... There are many strategies by which cell fates are decided. In one intriguing case, viruses communicate via the quorum-sensing-like ‘arbitrium’ system to bias infection outcomes. Through elucidating the detailed molecular mechanisms of such strategies, we can better understand viral propagation and offer insights into the treatment of viral diseases. ...
DOI:
10.1016/j.tim.2018.11.005

5. SnoRNAs and the emerging class of sdRNAs: Multifaceted players in oncogenesis

Author:
Abel, Yoann; Rederstorff, Mathieu
Source:
Biochimie 2019
ISSN:
0300-9084
Subject:
therapeutics,   etc   ; carcinogenesis; neoplasms; ribosomal RNA;     Show all 4 Subjects
Abstract:
... Small nucleolar RNAs are generally involved in the modification of target ribosomal RNAs. Other possible functions recently emerged with the discovery of the novel class of snoRNA-derived RNAs or sdRNAs. Since then, additional data has revealed the involvement of both snoRNAs and sdRNAs in tumorigenesis.After briefly introducing snoRNA families and functions, this mini-review summarises recently a ...
DOI:
10.1016/j.biochi.2019.05.006

6. Sending mixed signals: Cilia-dependent signaling during development and disease

Author:
Elliott, Kelsey H.; Brugmann, Samantha A.
Source:
Developmental biology 2019 v.447 no.1 pp. 28-41
ISSN:
0012-1606
Subject:
therapeutics,   etc   ; cilia; organelles; signal transduction;     Show all 4 Subjects
Abstract:
... Molecular signals are the guiding force of development, imparting direction upon cells to divide, migrate, differentiate, etc. The mechanisms by which a cell can receive and transduce these signals into measurable actions remains a ‘black box’ in developmental biology. Primary cilia are ubiquitous, microtubule-based organelles that dynamically extend from a cell to receive and process molecular an ...
DOI:
10.1016/j.ydbio.2018.03.007

7. Engineering therapeutic bispecific antibodies using CrossMab technology

Author:
Klein, Christian; Schaefer, Wolfgang; Regula, Joerg T.; Dumontet, Charles; Brinkmann, Ulrich; Bacac, Marina; Umaña, Pablo
Source:
Methods 2019 v.154 pp. 21-31
ISSN:
1046-2023
Subject:
therapeutics,   etc   ; antibodies; engineering; immunoglobulin G;     Show all 4 Subjects
Abstract:
... Bispecific antibodies have recently gained major interest as they allow novel mechanisms-of-action and/or therapeutic applications that cannot be achieved using conventional IgG-based antibodies. A major issue in engineering IgG-based bispecific antibodies has been to enable the correct association of heavy and light chains resulting in correct assembly of the desired bispecific antibody in suffic ...
DOI:
10.1016/j.ymeth.2018.11.008

8. L- asparaginase – A promising biocatalyst for industrial and clinical applications

Author:
Shakambari, Ganeshan; Ashokkumar, Balasubramaniem; Varalakshmi, Perumal
Source:
Biocatalysis and agricultural biotechnology 2019 v.17 pp. 213-224
ISSN:
1878-8181
Subject:
therapeutics,   etc   ; asparaginase; biocatalysts; food industry;     Show all 4 Subjects
Abstract:
... L-asparaginase is a versatile enzyme with application in food and therapeutics and under constant quest for a reliable microbial source for commercial production. The review is an aid to comprehend the key milestones of L-asparaginase ever since its discovery, its potential sources, economical production strategies using cheaply available alternate substrates, its purification and downstream proce ...
DOI:
10.1016/j.bcab.2018.11.018

9. LncRNA FAL1 promotes carcinogenesis by regulation of miR-637/NUPR1 pathway in colorectal cancer

Author:
Wang, Liqiang; Jiang, Fuquan; Xia, Xiaopu; Zhang, Bin
Source:
The international journal of biochemistry & cell biology 2019 v.106 pp. 46-56
ISSN:
1357-2725
Subject:
therapeutics,   etc   ; carcinogenesis; colorectal neoplasms; tissues;     Show all 4 Subjects
Abstract:
... LncRNA FAL1 has been demonstrated to play an important role in promoting carcinogenesis via the ceRNA mechanism in several types of cancer. However, the role and the mechanism of lncRNA FAL1 in CRC remain unclear. Here our results demonstrate that lncRNA FAL1 is markedly upregulated in CRC tissues and cells, and lncRNA FAL1 promotes proliferation ability, migration and invasion in CRC cells. Addit ...
DOI:
10.1016/j.biocel.2018.09.015

10. Future prospects for noncanonical amino acids in biological therapeutics

Author:
Rezhdo, Arlinda; Islam, Mariha; Huang, Manjie; Van Deventer, James A
Source:
Current opinion in biotechnology 2019 v.60 pp. 168-178
ISSN:
0958-1669
Subject:
therapeutics,   etc   ; amino acids; chemistry; medicinal properties; proteins;     Show all 5 Subjects
Abstract:
... There is growing evidence that noncanonical amino acids (ncAAs) can be utilized in the creation of biological therapeutics ranging from protein conjugates to cell-based therapies. However, when does genetically encoding ncAAs yield biologics with unique properties compared to other approaches? In this review, we attempt to answer this question in the broader context of therapeutic development, emp ...
DOI:
10.1016/j.copbio.2019.02.020

11. Use of Music Therapy in Aiding the Relaxation of Geriatric Horses

Author:
Wiśniewska, Marcjanna; Janczarek, Iwona; Wilk, Izabela; Wnuk-Pawlak, Elżbieta
Source:
Journal of equine veterinary science 2019 v.78 pp. 89-93
ISSN:
0737-0806
Subject:
therapeutics,   etc   ; animal behavior; heart rate; horses; music;     Show all 5 Subjects
Abstract:
... The aim of the study was to evaluate the effect of music therapy on changes in the level of parameters describing heart rate (HR) and heart rate variability (HRV) as excitability indicators in geriatric horses. The study involved 20 warmblood geriatric horses, aged 20 years or more. Animals were kept in two identical stables in one facility. Horses from stable No. 1 were considered the experimenta ...
DOI:
10.1016/j.jevs.2018.12.011

12. An analytical study on the fractional transient heating within the skin tissue during the thermal therapy

Author:
Ghanmi, Abdeljabbar; Abbas, Ibrahim A.
Source:
Journal of thermal biology 2019 v.82 pp. 229-233
ISSN:
0306-4565
Subject:
therapeutics,   etc   ; equations; fever; heat; models; tissues;     Show all 6 Subjects
Abstract:
... In the present paper, the bioheat equation under fractional derivatives is used to study the thermal damage within the skin tissue during the thermal therapy. Basically, the analytical solutions in the Laplace domain are easily obtainable. The influences of the fractional derivative and moving heat source velocity on the temperature of skin tissues and the thermal injuries are precisely investigat ...
DOI:
10.1016/j.jtherbio.2019.04.003

13. Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Author:
Braga Emidio, Nayara; Hoffmann, Werner; Brierley, Stuart M.; Muttenthaler, Markus
Source:
Trends in biochemical sciences 2019 v.44 no.5 pp. 387-390
ISSN:
0968-0004
Subject:
therapeutics,   etc   ; digestive system diseases; lectins; peptides;     Show all 4 Subjects
Abstract:
... The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo. ...
DOI:
10.1016/j.tibs.2019.01.004

14. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

Author:
Das, Saumya; Ansel, K. Mark; Bitzer, Markus; Breakefield, Xandra O.; Charest, Alain; Galas, David J.; Gerstein, Mark B.; Gupta, Mihir; Milosavljevic, Aleksandar; McManus, Michael T.; Patel, Tushar; Raffai, Robert L.; Rozowsky, Joel; Roth, Matthew E.; Saugstad, Julie A.; Van Keuren-Jensen, Kendall; Weaver, Alissa M.; Laurent, Louise C.; Abdel-Mageed, Asim B.; Adamidi, Catherine; Adelson, P. David; Akat, Kemal M.; Alsop, Eric; Ansel, K. Mark; Arango, Jorge; Aronin, Neil; Avsaroglu, Seda Kilinc; Azizian, Azadeh; Balaj, Leonora; Ben-Dov, Iddo Z.; Bertram, Karl; Bitzer, Markus; Blelloch, Robert; Bogardus, Kimberly A.; Breakefield, Xandra Owens; Calin, George A.; Carter, Bob S.; Charest, Al; Chen, Clark C.; Chitnis, Tanuja; Coffey, Robert J.; Courtright-Lim, Amanda; Das, Saumya; Datta, Amrita; DeHoff, Peter; Diacovo, Thomas G.; Erle, David J.; Etheridge, Alton; Ferrer, Marc; Franklin, Jeffrey L.; Freedman, Jane E.; Galas, David J.; Galeev, Timur; Gandhi, Roopali; Garcia, Aitor; Gerstein, Mark Bender; Ghai, Vikas; Ghiran, Ionita Calin; Giraldez, Maria D.; Goga, Andrei; Gogakos, Tasos; Goilav, Beatrice; Gould, Stephen J.; Guo, Peixuan; Gupta, Mihir; Hochberg, Fred; Huang, Bo; Huentelman, Matt; Hunter, Craig; Hutchins, Elizabeth; Jackson, Andrew R.; Kalani, M. Yashar S.; Kanlikilicer, Pinar; Karaszti, Reka Agnes; Van Keuren-Jensen, Kendall; Khvorova, Anastasia; Kim, Yong; Kim, Hogyoung; Kim, Taek Kyun; Kitchen, Robert; Kraig, Richard P.; Krichevsky, Anna M.; Kwong, Raymond Y.; Laurent, Louise C.; Lee, Minyoung; L’Etoile, Noelle; Levy, Shawn E.; Li, Feng; Li, Jenny; Li, Xin; Lopez-Berestein, Gabriel; Lucero, Rocco; Mateescu, Bogdan; Matin, A.C.; Max, Klaas E.A.; McManus, Michael T.; Mempel, Thorsten R.; Meyer, Cindy; Milosavljevic, Aleksandar; Mondal, Debasis; Mukamal, Kenneth Jay; Murillo, Oscar D.; Muthukumar, Thangamani; Nickerson, Deborah A.; O’Donnell, Christopher J.; Patel, Dinshaw J.; Patel, Tushar; Patton, James G.; Paul, Anu; Peskind, Elaine R.; Phelps, Mitch A.; Putterman, Chaim; Quesenberry, Peter J.; Quinn, Joseph F.; Raffai, Robert L.; Ranabothu, Saritha; Rao, Shannon Jiang; Rodriguez-Aguayo, Cristian; Rosenzweig, Anthony; Roth, Matthew E.; Rozowsky, Joel; Sabatine, Marc S.; Sakhanenko, Nikita A.; Saugstad, Julie Anne; Schmittgen, Thomas D.; Shah, Neethu; Shah, Ravi; Shedden, Kerby; Shi, Jian; Sood, Anil K.; Sopeyin, Anuoluwapo; Spengler, Ryan M.; Spetzler, Robert; Srinivasan, Srimeenakshi; Subramanian, Sai Lakshmi; Suthanthiran, Manikkam; Tanriverdi, Kahraman; Teng, Yun; Tewari, Muneesh; Thistlethwaite, William; Tuschl, Thomas; Urbanowicz, Karolina Kaczor; Vickers, Kasey C.; Voinnet, Olivier; Wang, Kai; Weaver, Alissa M.; Wei, Zhiyun; Weiner, Howard L.; Weiss, Zachary R.; Williams, Zev; Wong, David T.W.; Woodruff, Prescott G.; Xiao, Xinshu; Yan, Irene K.; Yeri, Ashish; Zhang, Bing; Zhang, Huang-Ge
Source:
Cell 2019 v.177 no.2 pp. 231-242
ISSN:
0092-8674
Subject:
therapeutics,   etc   ; RNA; biogenesis; biomarkers; cell communication;     Show all 5 Subjects
Abstract:
... The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exR ...
DOI:
10.1016/j.cell.2019.03.023

15. Sema6A-plexin-A2 axis stimulates RANKL-induced osteoclastogenesis through PLCγ-mediated NFATc1 activation

Author:
Zhuang, Jinliang; Li, Xun; Zhang, Yi; Shi, Ruixin; Shi, Ce; Yu, Dongsheng; Bao, Xingfu; Hu, Min
Source:
Life sciences 2019 v.222 pp. 29-35
ISSN:
0024-3205
Subject:
therapeutics,   etc   ; homeostasis; immunoglobulin G; osteoclasts; transcription factors;     Show all 5 Subjects
Abstract:
... Recently, several plexins and semaphorins have been associated with osteoclastogenesis, a vital process for bone remodeling. Plexin-A2 is implicated in bone homeostasis, however, whether it plays a role in osteoclastogenesis and the underlying mechanism remain unknown. We show that plexin-A2 expression is upregulated during RANKL-induced osteoclastogenesis. In addition, the soluble Sema6A fused wi ...
DOI:
10.1016/j.lfs.2019.01.060

16. A compendium on single‐cell analysis for the curious

Author:
Gallant, Caroline J.; Landegren, Ulf
Source:
TheFEBS journal 2019 v.286 no.8 pp. 1442-1444
ISSN:
1742-464X
Subject:
therapeutics,   etc   ; functional properties; humans; medicine; research programs;     Show all 5 Subjects
Abstract:
... Single‐cell analysis is impacting biology and medicine by changing the scale and resolution at which we investigate multicellular organisms. A particular, overarching aim of this field is to characterize the programmed development of all different cell types in the human body, as well as their individual spatial, molecular, and functional characteristics. This vast research program is generating a ...
DOI:
10.1111/febs.14820

17. Advanced Methods for Accessing Protein Shape-Shifting Present New Therapeutic Opportunities

Author:
Knoverek, Catherine R.; Amarasinghe, Gaya K.; Bowman, Gregory R.
Source:
Trends in biochemical sciences 2019 v.44 no.4 pp. 351-364
ISSN:
0968-0004
Subject:
therapeutics,   etc   ; computer analysis; protein conformation; proteins;     Show all 4 Subjects
Abstract:
... A protein is a dynamic shape-shifter whose function is determined by the set of structures it adopts. Unfortunately, atomically detailed structures are only available for a few conformations of any given protein, and these structures have limited explanatory and predictive power. Here, we provide a brief historical perspective on protein dynamics and introduce recent advances in computational and ...
DOI:
10.1016/j.tibs.2018.11.007

18. Bayesian predictive monitoring with bivariate binary outcomes in phase II clinical trials

Author:
Sambucini, Valeria
Source:
Computational statistics & data analysis 2019 v.132 pp. 18-30
ISSN:
0167-9473
Subject:
therapeutics,   etc   ; Bayesian theory; clinical trials; monitoring; probability;     Show all 5 Subjects
Abstract:
... Traditionally, phase II single-arm trials are based on a binary response variable that represents the efficacy of the experimental treatment. However, the introduction of an additional binary endpoint to assess whether the new therapy is also sufficiently safe for a further evaluation in larger phase III studies is often suggested. A Bayesian predictive strategy for interim monitoring in phase II ...
DOI:
10.1016/j.csda.2018.06.015

19. 3D Printing Enabled Customization of Functional Microgels

Author:
Liu, Xuan; Tao, Jie; Liu, Jinlu; Xu, Xin; Zhang, Jiumeng; Huang, Yulan; Chen, Yuwen; Zhang, Jing; Deng, David Y. B.; Gou, Maling; Wei, Yuquan
Source:
ACS applied materials & interfaces 2019 v.11 no.13 pp. 12209-12215
ISSN:
1944-8252
Subject:
therapeutics,   etc   ; drugs; materials science; microgels; mixing; polymerization;     Show all 6 Subjects
Abstract:
... Injectable microgels show great promising applications in cell therapy and drug delivery. Currently, there remains a challenge to rapidly and cost-effectively fabricate customized microgels. Here, we present a digital light processing based three-dimensional (3D) printing process to fabricate microgels with tailored shapes and sizes. The microgels are constructed by the digital light controlled po ...
DOI:
10.1021/acsami.8b18701

20. Polymerization-Induced Self-Assembly Generating Vesicles with Adjustable pH-Responsive Release Performance

Author:
Xu, Xiao-Fei; Pan, Cai-Yuan; Zhang, Wen-Jian; Hong, Chun-Yan
Source:
Macromolecules 2019 v.52 no.5 pp. 1965-1975
ISSN:
1520-5835
Subject:
therapeutics,   etc   ; copolymerization; drugs; hydrophobicity; pH; polymers;     Show all 6 Subjects
Abstract:
... Stimuli-responsive polymeric vesicles have attracted great attention in drug delivery due to their intrinsic hollow structures and “on demand” release of drugs upon environmental stimuli. The drug-release kinetics from polymeric vesicles, which is usually dependent on the stimuli-responsive behaviors of the polymeric vesicle, has great impacts on the therapeutic efficacy. Over the past decade, pol ...
DOI:
10.1021/acs.macromol.9b00144