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You searched for: Subject "threonine" Remove constraint Subject: "threonine"
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1. Modeling phytoremediation of heavy metal contaminated soils through machine learning

Author:
Liang Shi; Jie Li; Kumuduni Niroshika Palansooriya; Yahua Chen; Deyi Hou; Erik Meers; Daniel C.W. Tsang; Xiaonan Wang; Yong Sik Ok
Source:
Journal of hazardous materials 2023 v.441 pp. 129904
ISSN:
0304-3894
Subject:
threonine,   etc   ; Crassulaceae; adenosinetriphosphatase; bioaccumulation factor; heavy metals; hyperaccumulators; macrophages; malates; phytoaccumulation; secretion; soil;     Show all 11 Subjects
Abstract:
... As an important subtopic within phytoremediation, hyperaccumulators have garnered significant attention due to their ability of super-enriching heavy metals. Identifying the factors that affecting phytoextraction efficiency has important application value in guiding the efficient remediation of heavy metal contaminated soil. However, it is challenging to identify the critical factors that affect t ...
DOI:
10.1016/j.jhazmat.2022.129904

2. RPS6 transcriptional modulation in neural tissues of Nauphoeta cinerea during streptozotocin-associated sugar metabolism impairment.

Author:
Olawande C. Olagoke; Ana L.A. Segatto; Blessing A. Afolabi; Daniel Ardisson-Araujo; Michael Aschner; João B.T. Rocha
Source:
Comparative biochemistry and physiology 2023 v.263 pp. 110785
ISSN:
1096-4959
Subject:
non-specific serine/threonine protein kinase,   etc   ; Nauphoeta cinerea; biomedical research; brain; glucose; hyperglycemia; insects; metabolism; peptides; ribosomal proteins; sequence analysis; streptozotocin; transcription (genetics);     Show all 13 Subjects
Abstract:
... The use of insects to model molecular events that characterize degenerative conditions was originally met with scepticism. However, the discovery of insect insulin-like peptides in the 1970's and the demonstration of evolutionary conservation of insulin-related signalling from insects to mammals have highlighted the importance and reduced cost of insect models in biomedical research. Here, we expa ...
DOI:
10.1016/j.cbpb.2022.110785

3. Metabolomic analyses reveal potential mechanisms induced by melatonin application for tolerance of water deficit in loquat (Eriobotrya japonica Lindl.)

Author:
Dan Wang; Qiyang Chen; Qigao Guo; Yan Xia; Danlong Jing; Guolu Liang
Source:
Scientia horticulturae 2023 v.308 pp. 111569
ISSN:
0304-4238
Subject:
threonine,   etc   ; Eriobotrya japonica; antioxidant enzymes; asparagine; biosynthesis; electrolyte leakage; enzyme activity; ferulic acid; flavonols; galactose; glutamic acid; loquats; melatonin; metabolites; metabolomics; shikimic acid; stress tolerance; valine; water content; water stress;     Show all 20 Subjects
Abstract:
... Melatonin participates in the response to abiotic stressors in plants and enhances tolerance to water stress tolerance in loquat seedlings; however, the underlying mechanism remains unknown. In this study, we conducted physiological and metabolomic analyses to identify the metabolic processes associated with enhanced tolerance of melatonin-treated loquat seedlings under conditions of water deficit ...
DOI:
10.1016/j.scienta.2022.111569

4. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221

Author:
Jie Yang; Zi-Xuan Wang; Lei Fang; Tu-Shuai Li; Zhi-Hong Liu; Ying Pan; Ling-Dong Kong
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115688
ISSN:
0378-8741
Subject:
non-specific serine/threonine protein kinase,   etc   ; Atractylodes lancea; Magnolia officinalis; Oriental traditional medicine; Western blotting; adiponectin receptors; agonists; animal models; diet; fluorescent antibody technique; fructose; humans; insulin; insulin resistance; kidneys; liquid chromatography; pharmacology; rats; tandem mass spectrometry; therapeutics; thermosensitivity;     Show all 21 Subjects
Abstract:
... In traditional Chinese medicine, a long term of improper diet causes the Dampness and disturbs Zang-Fu's functions including Kidney deficiency. Atractylodes lancea (Atr) and Magnolia officinalis (Mag) as a famous herb pair are commonly used to transform Dampness, with kidney protection. To explore how Atr and Mag protected against insulin signaling impairment in glomerular podocytes induced by hig ...
DOI:
10.1016/j.jep.2022.115688

5. Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation

Author:
Daiki Sato; Masaya Denda; Honoka Tsunematsu; Naonobu Tanaka; Isamu Konishi; Chiaki Komiya; Akira Shigenaga; Akira Otaka
Source:
Chemical communications 2022 v.58 no.17 pp. 2918-2921
ISSN:
1364-548X
Subject:
threonine,   etc   ; peptides; thioesters;     Show all 3 Subjects
Abstract:
... Intramolecular S-acylation of a thiol-installed threonine with a thioester unit, followed by S–O acyl transfer and subsequent desulphurisation, allows the synthesis of lactone peptides. A protocol has been developed enabling the cyclisation of a linear peptide, a reaction which has not been achieved by conventional methods. ...
DOI:
10.1039/d1cc07248j

6. Synthetic Approach to the Natural N-Nitrosohydroxylamino Tetramic Acid JBIR-141

Author:
Lea Wittmann; Anja C. Wachter; Hedda Schrey; Rainer Schobert
Source:
Organic letters 2022 v.24 no.28 pp. 5171-5175
ISSN:
1523-7052
Subject:
threonine,   etc   ; alanine; glutamic acid; metabolites;     Show all 4 Subjects
Abstract:
... An analogue of the Streptomyces metabolite JBIR-141, featuring a delicate N-nitrosohydroxylamine, a 3-acyltetramic acid, and an oxazoline, was synthesized by a convergent strategy from l-alanine, l-threonine, and l-glutamic acid. Key steps were the cyclization of an Ala–Thr derivative to give the oxazoline, a Dieckmann condensation affording the 3-acyltetramic acid, and the N-nitrosation of a hydr ...
DOI:
10.1021/acs.orglett.2c02006

7. Collective Impact of Amino Acids on Clathrate Hydrates of the CO₂ + CH₄ Gas Mixture

Author:
Sai Kiran Burla; Bhavya Tulluru; Pinnelli S. R. Prasad
Source:
Energy & fuels 2022 v.36 no.18 pp. 10618-10626
ISSN:
1520-5029
Subject:
threonine,   etc   ; carbon dioxide; energy; hydrophilicity; hydrophobicity; phenylalanine; valine;     Show all 7 Subjects
Abstract:
... The amino acids are imposing additives in the gas-hydrate-based technology, and they play a dual role as inhibitors or promoters, primarily depending upon the concentration. Additionally, the nature of the side chain and its length are critical in the process. l-Phenylalanine (l-Phe) and l-threonine (l-Thr) are classified as hydrophobic and hydrophilic, respectively, and are more potent inhibitors ...
DOI:
10.1021/acs.energyfuels.2c01329

8. The ORF45 Protein of Kaposi’s Sarcoma-Associated Herpesvirus and Its Critical Role in the Viral Life Cycle

Author:
Natalie Atyeo; Bernadett Papp
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
non-specific serine/threonine protein kinase,   etc   ; capsid; interferons;     Show all 3 Subjects
Abstract:
... Kaposi’s sarcoma-associated herpesvirus (KSHV) protein ORF45 is a virion-associated tegument protein that is unique to the gammaherpesvirus family. Generation of KSHV ORF45-knockout mutants and their subsequent functional analyses have permitted a better understanding of ORF45 and its context-specific and vital role in the KSHV lytic cycle. ORF45 is a multifaceted protein that promotes infection a ...
DOI:
10.3390/v14092010

9. Dynamic Regulation of Transporter Expression to Increase L-Threonine Production Using L-Threonine Biosensors

Author:
Sumeng Wang; Ruxin Hao; Xin Jin; Xiaomeng Li; Qingsheng Qi; Quanfeng Liang
Source:
Fermentation 2022 v.8 no.6 pp. -
ISSN:
2311-5637
Subject:
threonine,   etc   ; autoregulation; biosensors; cytotoxicity; glucose; liquid state fermentation;     Show all 6 Subjects
Abstract:
... The cytotoxicity of overexpressed transporters limits their application in biochemical production. To overcome this problem, we developed a feedback circuit for L-threonine production that uses a biosensor to regulate transporter expression. First, we used IPTG-induced rhtA regulation, L-threonine exporter, to simulate dynamic regulation for improving L-threonine production, and the results show t ...
DOI:
10.3390/fermentation8060250

10. miR-193a-3p increases glycolysis under hypoxia by facilitating Akt phosphorylation and PFKFB3 activation in human macrophages

Author:
Dominik C. Fuhrmann; Bernhard Brüne
Source:
Cellular and molecular life sciences 2022 v.79 no.2 pp. 89
ISSN:
1420-682X
Subject:
threonine,   etc   ; dephosphorylation; glycolysis; humans; hypoxia; macrophages; microRNA; oxygen; phosphorylation;     Show all 9 Subjects
Abstract:
... Human macrophages infiltrating hypoxic regions alter their metabolism, because oxygen becomes limited. Increased glycolysis is one of the most common cellular adaptations to hypoxia and mostly is regulated via hypoxia-inducible factor (HIF) and RAC-alpha serine/threonine–protein kinase (Akt) signaling, which gets activated under reduced oxygen content. We noticed that micro RNA (miR)-193a-3p enhan ...
DOI:
10.1007/s00018-022-04146-z

11. Formation of brominated halonitromethanes from threonine involving bromide ion during the UV/chlorine disinfection

Author:
Tao Wang; Lin Deng; Wenjuan Dai; Jun Hu; Rajendra Prasad Singh; Chaoqun Tan
Source:
Journal of cleaner production 2022 v.373 pp. 133897
ISSN:
0959-6526
Subject:
threonine,   etc   ; bromination; bromine; chlorine; cytotoxicity; disinfection; genotoxicity; pH; wastewater;     Show all 9 Subjects
Abstract:
... Numerous disinfection by-products (DBPs) are produced during the disinfection process of drinking water and wastewater, and brominated halonitromethanes (Br-HNMs) have aroused great concerns because of much higher cytotoxicity and genotoxicity than common regulated DBPs. Threonine was selected as the precursor for the investigation of Br-HNMs formation in the presence of bromide ion (Br⁻) during t ...
DOI:
10.1016/j.jclepro.2022.133897

12. Do Thiol Amino Acids Inhibit Threonine Deaminase Activity in E. coli? (Letter to the Editor)

Author:
Mikhail M. Gusyatiner
Source:
Current microbiology 2022 v.79 no.2 pp. 42
ISSN:
0343-8651
Subject:
threonine,   etc   ; Escherichia coli; cysteine; growth retardation; homocysteine; isoleucine; microbiology; thiols;     Show all 8 Subjects
Abstract:
... Cysteine and homocysteine suppress the growth of Escherichia coli. It was explained by the inhibition of threonine deaminase (TD) (Harris in J Bacteriol 145(2):1031–1035, 1981). TD inhibition was detected by a decline in its product, 2-ketobutyrate (2-KB). We propose that cysteine or homocysteine may not inhibit TD activity. Instead, 2-KB binds to them forming stable cyclic adducts. This binding p ...
DOI:
10.1007/s00284-021-02738-9

13. Evaluation of a threonine fermentation product as a digestible threonine source in broilers

Author:
Lee D.T.; J.T. Lee; A.J. Ashworth; M.T. Kidd; A. Mauromoustakos; S.J. Rochell
Source:
Journal of applied poultry research 2022 v.31 no.3 pp. 100252
ISSN:
1056-6171
Subject:
threonine,   etc   ; breasts; cellulose; diet; energy; feed intake; fermented foods; research;     Show all 8 Subjects
Abstract:
... In the present experiment, a Thr fermentation product (FP) (75% minimum digestible Thr) was evaluated as a replacement for crystalline L-Thr (98.5% minimum digestible Thr) as a source of digestible Thr and other nutrients to support broiler performance (0–48 d) and processing characteristics. Five phase-fed diets included 1) a positive control (PC) diet containing L-Met, L-Lys•HCl, and L-Thr, 2) a ...
Handle:
10113/7716400
DOI:
10.1016/j.japr.2022.100252

14. The potential roles of amino acids and their major derivatives in the management of multiple sclerosis

Author:
Somayeh Pashaei; Reza Yarani; Pantea Mohammadi; Mohammad Sajad Emami Aleagha
Source:
Amino acids 2022 v.54 no.6 pp. 841-858
ISSN:
0939-4451
Subject:
threonine,   etc   ; glutamic acid; pathogenesis; phenylalanine; prognosis; sclerosis; serotonin; therapeutics; tryptophan;     Show all 9 Subjects
Abstract:
... Recently, we reviewed the important role of carbohydrates and lipids metabolism in different clinical aspects of multiple sclerosis (MS) disease. In the current paper, we aimed to review the contribution of amino acids and their major derivatives to different clinical outcomes of the disease, including etiology, pathogenesis, diagnosis, prognosis, and treatment. In this line, Thr (threonine), Phe ...
DOI:
10.1007/s00726-022-03162-4

15. Total synthesis of chaiyaphumines A-D: A case study comparing macrolactonization and macrolactamization approaches

Author:
Heyuan Lu; Robert A. Batey
Source:
Tetrahedron letters 2022 v.108 pp. 154138
ISSN:
0040-4039
Subject:
threonine,   etc   ; acylation; antimalarials; case studies; chlorides; crystal structure; depsipeptides; lanthanides;     Show all 8 Subjects
Abstract:
... A comparison of macrolactonization and macrolactamization approaches to the synthesis of the pentadepsipeptide chaiyaphumines is outlined. Fmoc-based solid-phase synthesis approaches were used for the synthesis of the requisite precursors. Attempted solution-phase macrolactonization of a seco-acid precursor using Yamaguchi, pivaloyl chloride, or MNBA activation did not give cyclized products. The ...
DOI:
10.1016/j.tetlet.2022.154138

16. New trend in ligand-induced EGFR trafficking: A dual-mode clathrin-mediated endocytosis model

Author:
Yue Zhou; Hiroaki Sakurai
Source:
Journal of proteomics 2022 v.255 pp. 104503
ISSN:
1874-3919
Subject:
threonine,   etc   ; endocytosis; epidermal growth factor receptors; models; phosphorylation; proteomics; serine; therapeutics;     Show all 8 Subjects
Abstract:
... Accumulated evidence has established that ligand-bound activated epidermal growth factor receptor (EGFR) dimers rapidly undergo endocytosis via clathrin-mediated endocytosis (CME) and clathrin-independent endocytosis (CIE), and are then sorted to recycling and degradation pathways, respectively. On the other hand, cellular stress triggers the non-canonical CME of ligand-free EGFR monomers via the ...
DOI:
10.1016/j.jprot.2022.104503

17. Involvement of serine / threonine protein kinases in DNA damage response and cell division in bacteria

Author:
Yogendra S. Rajpurohit; Dhirendra Kumar Sharma; Hari S. Misra
Source:
Research in microbiology 2022 v.173 no.1-2 pp. 103883
ISSN:
0923-2508
Subject:
threonine,   etc   ; DNA damage; bacteria; cell division; microbial physiology; pathogenesis; research; serine;     Show all 8 Subjects
Abstract:
... The roles of Serine/Threonine protein kinases (STPKs) in bacterial physiology, including bacterial responses to nutritional stresses and under pathogenesis have been well documented. STPKs roles in bacterial cell cycle regulation and DNA damage response have not been much emphasized, possibly because the LexA/RecA type SOS response became the synonym to DNA damage response and cell cycle regulatio ...
DOI:
10.1016/j.resmic.2021.103883

18. Development of efficient microbial cell factory for whole-cell bioconversion of L-threonine to 2-hydroxybutyric acid

Author:
Thai Le; Sunghoon Park
Source:
Bioresource technology 2022 v.344 pp. 126090
ISSN:
0960-8524
Subject:
threonine,   etc   ; Candida boidinii; Cupriavidus necator; Escherichia coli; biotransformation; formate dehydrogenase; mutants; technology;     Show all 8 Subjects
Abstract:
... Production of 2-hydroxybutyric acid (2-HBA) was attempted in recombinant Escherichia coli W3110 Δtdh ΔilvIH (over)expressing a homologous and mutated threonine dehydratase (ilvA*) and a heterologous 2-ketobutyric acid (2-KBA) reductase from Alcaligenes eutrophus H16 (Ae_ldh). To prevent the degradation of 2-KBA, the aceE, poxB and pflB genes were deleted, and for blocking the 2-HBA degradation, th ...
DOI:
10.1016/j.biortech.2021.126090

19. Insights on CO₂ Hydrate Formation and Dissociation Kinetics of Amino Acids in a Brine Solution

Author:
Amirun Nissa Rehman; Cornelius B. Bavoh; Bhajan Lal; Khalik M. Sabil; Jitendra S. Sangwai
Source:
Industrial & engineering chemistry process design and development 2022 v.61 no.37 pp. 13863-13876
ISSN:
1520-5045
Subject:
threonine,   etc   ; brine solutions; carbon dioxide; dissociation; process design; sodium dodecyl sulfate; temperature;     Show all 7 Subjects
Abstract:
... CO₂ sequestration as hydrates has captured enormous research interest in recent years due to its high storage capacity. However, the slow hydrate formation kinetics poses a strong challenge in its applicability and urges the need for additives (kinetic promoters) to accelerate the hydrate formation kinetics. This study investigates the performance of amino acid solutions in brine (3.3 wt % NaCl) o ...
DOI:
10.1021/acs.iecr.2c02178

20. mTOR substrate phosphorylation in growth control

Author:
Stefania Battaglioni; Don Benjamin; Matthias Wälchli; Timm Maier; Michael N. Hall
Source:
Cell 2022 v.185 no.11 pp. 1814-1836
ISSN:
0092-8674
Subject:
threonine,   etc   ; biomass; cell growth; energy; mammals; metabolism; phosphorylation; protein subunits; rapamycin; serine;     Show all 10 Subjects
Abstract:
... The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved serine/threonine protein kinase that plays a central role in regulating cell growth and metabolism. It is activated by nutrients, growth factors, and cellular energy. TOR forms two structurally and functionally distinct complexes, TORC1 and TORC2. TOR signaling activates cell growth, defined as an increase in biomass, by ...
DOI:
10.1016/j.cell.2022.04.013