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1. Nanotechnology, and scaffold implantation for the effective repair of injured organs: An overview on hard tissue engineering

Author:
Abdollahiyan, Parinaz; Oroojalian, Fatemeh; Hejazi, Maryam; de la Guardia, Miguel; Mokhtarzadeh, Ahad
Source:
Journal of controlled release 2021 v.333 pp. 391-417
ISSN:
0168-3659
Subject:
tissue repair,   etc   ; bioprinting; cartilage; mineralization;     Show all 4 Subjects
Abstract:
... The tissue engineering of hard organs and tissues containing cartilage, teeth, and bones is a widely used and rapidly progressing field. One of the main features of hard organs and tissues is the mineralization of their extracellular matrices (ECM) to enable them to withstand pressure and weight. Recently, a variety of printing strategies have been developed to facilitate hard organ and tissue reg ...
DOI:
10.1016/j.jconrel.2021.04.003

2. GRF-GIF Chimeras Boost Plant Regeneration

Author:
Luo, Guangbin; Palmgren, Michael
Source:
Trends in plant science 2021 v.26 no.3 pp. 201-204
ISSN:
1360-1385
Subject:
tissue culture,   etc   ; chimerism; gene editing;     Show all 3 Subjects
Abstract:
... Low regeneration efficiency hampers plant transformation. Two independent studies demonstrate that GROWTH-REGULATING FACTORs (GRFs) alone or in chimeras with GRF-INTERACTING FACTOR (GIF) dramatically boost regeneration from tissue cultures from a broad range of species. GRF-GIF chimeras could be a game-changer in plant transformation and gene editing. ...
DOI:
10.1016/j.tplants.2020.12.001

3. The Cat Mandible (I): Anatomical Basis to Avoid Iatrogenic Damage in Veterinary Clinical Practice

Author:
Lombardero, Matilde; Alonso-Peñarando, Diana; Yllera, María del Mar
Source:
Animals 2021 v.11 no.2
ISSN:
2076-2615
Subject:
nerve tissue,   etc   ; cats; dogs; gingiva;     Show all 4 Subjects
Abstract:
... Cats are one of our favourite pets in the home. They differ considerably from dogs but are usually treated clinically as small dogs, despite some anatomical and physiological dissimilarities. Their mandible is small and has some peculiarities relative to the dentition (only three incisors, a prominent canine, two premolars and one molar); a conical and horizontally oriented condyle, and a protuden ...
DOI:
10.3390/ani11020405

4. Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases

Author:
Andrews, Darrell; Godson, Catherine
Source:
Biochimica et biophysica acta 2021 v.1866 no.8 pp. 158940
ISSN:
1388-1981
Subject:
tissue repair,   etc   ; inflammation; kidney diseases; lipids; therapeutics;     Show all 5 Subjects
Abstract:
... Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics. However, these are associated with undesirable side effects including immune suppression. ...
DOI:
10.1016/j.bbalip.2021.158940

5. Light-up photoluminescence sensing of a nerve agent simulant by a bis-porphyrin–salen–UO₂ complex

Author:
Gangemi, Chiara Maria Antonietta; Rimkaite, Ugne; Pappalardo, Andrea; Trusso Sfrazzetto, Giuseppe
Source:
RSC advances 2021 v.11 no.22 pp. 13047-13050
ISSN:
2046-2069
Subject:
nerve tissue,   etc   ; fluorescence; nerve agents; paper; photoluminescence;     Show all 5 Subjects
Abstract:
... A luminescent bis-porphyrin–salen–UO₂ complex, showing a significant fluorescence light-up response upon reacting with DMMP (a simulant of nerve agents), is reported. The fluorescence change of this complex by excitation at 365 nm can be clearly observed with the naked eye, and this complex was successfully employed to construct a test paper to detect nerve agents. ...
DOI:
10.1039/d1ra01397a

6. Chromo-fluorogenic sensors for chemical warfare agents in real-time analysis: journey towards accurate detection and differentiation

Author:
Kumar, Vinod
Source:
Chemical communications 2021 v.57 no.28 pp. 3430-3444
ISSN:
1364-548X
Subject:
nerve tissue,   etc   ; ambient temperature; chemical species;     Show all 3 Subjects
Abstract:
... The existence of chemical weapons (blister and nerve agents) is an unfortunate reality of the modern world. The usage of these chemical agents by rogue states or terrorist groups has showcased their ugly faces in the past and even in recent years. Despite extensive and strenuous efforts by the Organization for the Prohibition of Chemical Weapons (OPCW) to eliminate chemical warfare agents (CWAs) b ...
DOI:
10.1039/d1cc00132a

7. Accurate and sensitive analysis of Staphylococcus aureus through CRISPR-Cas12a based recycling signal amplification cascades for early diagnosis of skin and soft tissue infections

Author:
Wei, JingJing
Source:
Journal of microbiological methods 2021 v.183 pp. 106167
ISSN:
0167-7012
Subject:
tissues,   etc   ; Staphylococcus aureus; early diagnosis; enzymes; oligonucleotides;     Show all 5 Subjects
Abstract:
... Early-diagnosis and treatments of skin and soft tissue infections remain a huge challenge due to the difficulties in the detection of trace amounts of bacteria. We develop here a novel method through CRISPR-Cas12a based recycling signal amplification cascades and demonstrated its feasibility of Staphylococcus aureus detection in a sensitive and accurate way. The highlights of the proposed method a ...
DOI:
10.1016/j.mimet.2021.106167

8. Non‐lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins

Author:
Arama, Eli; Baena‐Lopez, Luis Alberto; Fearnhead, Howard O.
Source:
TheFEBS journal 2021 v.288 no.7 pp. 2166-2183
ISSN:
1742-464X
Subject:
tissue repair,   etc   ; Animalia; apoptosis; caspases; homeostasis;     Show all 5 Subjects
Abstract:
... Apoptosis is a major form of programmed cell death (PCD) that eliminates unnecessary and potentially dangerous cells in all metazoan organisms, thus ensuring tissue homeostasis and many developmental processes. Accordingly, defects in the activation of the apoptotic pathway often pave the way to disease. After several decades of intensive research, the molecular details controlling the apoptosis p ...
DOI:
10.1111/febs.15547

9. Cellular and molecular profiles of anterior nervous system regeneration in Diopatra claparedii Grube, 1878 (Annelida, Polychaeta)

Author:
Ahmad Nazri, Mohd Ulul Ilmie; Mahmud, Mohd Hafizi; Saidi, Basri; Mat Isa, Mohd Noor; Ehsak, Zolkapli; Ross, Othman; Idris, Izwandy; Ismail, Wan Iryani Wan
Source:
Heliyon 2021 v.7 no.2 pp. e06307
ISSN:
2405-8440
Subject:
nerve tissue,   etc   ; Polychaeta; brain; lysosomes; mitochondria;     Show all 5 Subjects
Abstract:
... The polychaete Diopatra claparedii Grube, 1878 is among those organisms successfully carrying out full body regeneration, including the whole nervous system. Thus, D. claparedii potentially can be regarded for the nervous system regeneration (NSR) study. However, data on the property of its nervous system and the NSR profile are still lacking. In this study, we investigated the morphology of D. cl ...
DOI:
10.1016/j.heliyon.2021.e06307

10. Bioprinting for the Biologist

Author:
Daly, Andrew C.; Prendergast, Margaret E.; Hughes, Alex J.; Burdick, Jason A.
Source:
Cell 2021 v.184 no.1 pp. 18-32
ISSN:
0092-8674
Subject:
tissue repair,   etc   ; bioprinting; drugs; extrusion; morphogenesis; therapeutics;     Show all 6 Subjects
Abstract:
... Building tissues from scratch to explore entirely new cell configurations could revolutionize fundamental understanding in biology. Bioprinting is an emerging technology to do this. Although typically applied to engineer tissues for therapeutic tissue repair or drug screening, there are many opportunities for bioprinting within biology, such as for exploring cellular crosstalk or cellular morphoge ...
DOI:
10.1016/j.cell.2020.12.002

11. AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants

Author:
Ostinelli, Giada; Vijay, Jinchu; Vohl, Marie-Claude; Grundberg, Elin; Tchernof, Andre
Source:
Molecular and cellular endocrinology 2021 v.527 pp. 111220
ISSN:
0303-7207
Subject:
adipose tissue; tissue distribution,   etc   ; RNA; adipocytes; adipogenesis; androgens; body fat distribution; epigenome; glucocorticoid receptors; glucocorticoids; heritability;     Show all 11 Subjects
Abstract:
... Changes in androgen dynamics within adipose tissue have been proposed as modulators of body fat accumulation. In this context, AKR1C2 likely plays a significant role by inactivating 5α-dihydrotestosterone.To characterize AKR1C2 expression patterns across adipose depots and cell populations and to provide insight into the link with body fat distribution and genetic regulation.We used RNA sequencing ...
DOI:
10.1016/j.mce.2021.111220

12. Transcription Profile of Potato (Solanum tuberosum L.) Growing In Vitro

Author:
Dobránszki, Judit; Hidvégi, Norbert; Gulyás, Andrea; Tóth, Bianka; Teixeira da Silva, Jaime A.
Source:
Journal of plant growth regulation 2021 v.40 no.2 pp. 749-760
ISSN:
0721-7595
Subject:
plant tissues; tissue culture,   etc   ; Solanum tuberosum; plant growth; plantlets; potatoes; sequence analysis; transcription (genetics); transcriptomics;     Show all 9 Subjects
Abstract:
... Despite countless papers on plant tissue culture, few have assessed the transcriptional changes that occur in a developing explant from the moment it is cut and plated, and during early stages of development. In this study, the mRNA profile of in vitro potato (Solanum tuberosum L.) plantlets derived from internode stems was assessed via four comparisons during five time intervals (0 h, 24 h, 48 h, ...
DOI:
10.1007/s00344-020-10133-0

13. Development and validation of a sensitive LC-MS/MS method for pioglitazone: application towards pharmacokinetic and tissue distribution study in rats

Author:
G., Kusuma Kumari; Thaggikuppe Krishnamurthy, Praveen; Ammu V. V. V., Ravi Kiran; Vishwanath, Kurawattimath; Narenderan, S. T.; Babu, B.; Krishnaveni, Nagappan
Source:
RSC advances 2021 v.11 no.19 pp. 11437-11443
ISSN:
2046-2069
Subject:
adipose tissue; tissue distribution,   etc   ; acetonitrile; brain; formic acid; ionization; kidneys; pharmacokinetics; rats;     Show all 9 Subjects
Abstract:
... In the present study, a sensitive LC-MS/MS method was developed and validated to measure pioglitazone (PGZ) concentrations in rat plasma and tissues. The chromatographic separation was achieved by using a YMC Pro C₁₈ column (100 mm × 4.6 mm, 3μ) with a mobile phase consisting of formic acid (0.1% v/v) and acetonitrile (5 : 95) at a flow rate of 0.7 mL min⁻¹ and injection volume of 10 μL (IS: rosig ...
DOI:
10.1039/d1ra01126j

14. Multidrug-loaded electrospun micro/nanofibrous membranes: Fabrication strategies, release behaviors and applications in regenerative medicine

Author:
Lan, Xingzi; Wang, Han; Bai, Jianfu; Miao, Xiaomin; Lin, Quan; Zheng, Jianpei; Ding, Shukai; Li, Xiaoran; Tang, Yadong
Source:
Journal of controlled release 2021 v.330 pp. 1264-1287
ISSN:
0168-3659
Subject:
tissue engineering; tissue repair,   etc   ; adhesion; adverse effects; drug delivery systems; drugs; medicine; nanofibers; nerve regeneration; synergism;     Show all 10 Subjects
Abstract:
... Electrospun micro/nanofibrous membranes (EFMs) have been widely investigated as local drug delivery systems. Multiple drugs can be simultaneously incorporated into one EFM to create synergistic effects, reduce side effects, and play their respective roles in the complex physiological processes of tissue regeneration and postoperative adhesion prevention. Due to the versatile electrospinning techni ...
DOI:
10.1016/j.jconrel.2020.11.036

15. Relationship of visceral adiposity index with new-onset proteinuria in hypertensive patients

Author:
Liu, Mengyi; Zhou, Chun; Zhang, Zhuxian; He, Panpan; Zhang, Yuanyuan; Xie, Di; Nie, Jing; Liang, Min; Song, Yun; Liu, Chengzhang; Liu, Lishun; Huo, Yong; Wang, Binyan; Wang, Xiaobin; Xu, Xiping; Qin, Xianhui
Source:
Clinical nutrition 2021 v.40 no.2 pp. 438-444
ISSN:
0261-5614
Subject:
adipose tissue; tissue distribution,   etc   ; adiposity; folic acid; hyperlipidemia; obesity; patients; proteinuria; risk; stroke; urine; China;     Show all 12 Subjects
Abstract:
... Visceral adiposity index (VAI) is a sex-specific surrogate marker of adipose tissue distribution and function. Little is known about the longitudinal relationship between VAI and proteinuria. This study aimed to examine the prospective relationship of baseline VAI with new-onset of proteinuria in hypertensive patients without major cardiovascular diseases.A total of 10 699 hypertensive patients wi ...
DOI:
10.1016/j.clnu.2020.05.031

16. Tissue-specific engineering: 3D bioprinting in regenerative medicine

Author:
Wang, Zhen; Kapadia, Wasim; Li, Cuidi; Lin, Feng; Pereira, Ruben F.; Granja, Pedro L.; Sarmento, Bruno; Cui, Wenguo
Source:
Journal of controlled release 2021 v.329 pp. 237-256
ISSN:
0168-3659
Subject:
muscle tissues; nerve tissue,   etc   ; biocompatible materials; bioprinting; epithelium; histology; humans; medicine; therapeutics;     Show all 9 Subjects
Abstract:
... Despite its complexity, the human body is composed of only four basic tissue types, namely epithelial, connective, muscular and nervous tissues. Notably, each tissue is an assemblage of similarly functional cells united in performing a specific function. Instead of mimicking functionality mechanically, three-dimensional (3D) bioprinting based on histological categories is a strategy designed with ...
DOI:
10.1016/j.jconrel.2020.11.044

17. Re-engineering Artificial Neoplastic Milieus: Taking Lessons from Mechano- and Topobiology

Author:
Leal-Egaña, Aldo; Balland, Martial; Boccaccini, Aldo R.
Source:
Trends in biotechnology 2020 v.38 no.2 pp. 142-153
ISSN:
0167-7799
Subject:
tissue engineering; tissue repair; tissues,   etc   ; biophysics; cell growth; niches;     Show all 6 Subjects
Abstract:
... Traditionally, cancer-like scaffolds have been developed with tissue regeneration in mind and therefore designed to mimic the regenerative environment of otherwise healthy tissues. However, the tumoral niche exhibits specific biophysical cues far from being ‘cell friendly’, suggesting that a different approach should be taken to design these artificial neoplastic niches. From bare 2D surfaces to 3 ...
DOI:
10.1016/j.tibtech.2019.08.003

18. PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis

Author:
Zhang, Yuhua; Quick, Corbin; Yu, Ketian; Barbeira, Alvaro; Luca, Francesca; Pique-Regi, Roger; Kyung Im, Hae; Wen, Xiaoquan
Source:
Genome biology 2020 v.21 no.1 pp. 232
ISSN:
1474-760X
Subject:
tissues,   etc   ; gene expression; statistics;     Show all 3 Subjects
Abstract:
... We propose a new computational framework, probabilistic transcriptome-wide association study (PTWAS), to investigate causal relationships between gene expressions and complex traits. PTWAS applies the established principles from instrumental variables analysis and takes advantage of probabilistic eQTL annotations to delineate and tackle the unique challenges arising in TWAS. PTWAS not only confers ...
DOI:
10.1186/s13059-020-02026-y

19. Single-cell revolution unveils the mysteries of the regenerative mammalian digit tip

Author:
Riquelme-Guzmán, Camilo; Contreras, Osvaldo
Source:
Developmental biology 2020 v.461 no.2 pp. 107-109
ISSN:
0012-1606
Subject:
tissue repair,   etc   ; mammals; models;     Show all 3 Subjects
Abstract:
... The digit tip is an exciting model for studying regeneration in mammals, but the precise mechanisms and the populations of cells involved in the formation and remodeling of the blastema remain unknown. In an exciting new work, Storer et al. take advantage of single-cell RNAseq combined with Pdgfra+ ​lineage-tracing to open the way into the enigmatic world of mammalian tissue regeneration. ...
DOI:
10.1016/j.ydbio.2020.02.002

20. Using Remote Fields for Complex Tissue Engineering

Author:
Armstrong, James P.K.; Stevens, Molly M.
Source:
Trends in biotechnology 2020 v.38 no.3 pp. 254-263
ISSN:
0167-7799
Subject:
tissue engineering,   etc   ; acoustics; magnetism;     Show all 3 Subjects
Abstract:
... Great strides have been taken towards the in vitro engineering of clinically relevant tissue constructs using the classic triad of cells, materials, and biochemical factors. In this perspective, we highlight ways in which these elements can be manipulated or stimulated using a fourth component: the application of remote fields. This arena has gained great momentum over the last few years, with a r ...
DOI:
10.1016/j.tibtech.2019.07.005
PubMed:
31439372
PubMed Central:
PMC7023978