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1. Re-engineering Artificial Neoplastic Milieus: Taking Lessons from Mechano- and Topobiology

Author:
Leal-Egaña, Aldo; Balland, Martial; Boccaccini, Aldo R.
Source:
Trends in biotechnology 2020 v.38 no.2 pp. 142-153
ISSN:
0167-7799
Subject:
tissue engineering; tissue repair; tissues,   etc   ; biophysics; cell growth; niches;     Show all 6 Subjects
Abstract:
... Traditionally, cancer-like scaffolds have been developed with tissue regeneration in mind and therefore designed to mimic the regenerative environment of otherwise healthy tissues. However, the tumoral niche exhibits specific biophysical cues far from being ‘cell friendly’, suggesting that a different approach should be taken to design these artificial neoplastic niches. From bare 2D surfaces to 3 ...
DOI:
10.1016/j.tibtech.2019.08.003

2. Using Remote Fields for Complex Tissue Engineering

Author:
Armstrong, James P.K.; Stevens, Molly M.
Source:
Trends in biotechnology 2020 v.38 no.3 pp. 254-263
ISSN:
0167-7799
Subject:
tissue engineering,   etc   ; acoustics; magnetism;     Show all 3 Subjects
Abstract:
... Great strides have been taken towards the in vitro engineering of clinically relevant tissue constructs using the classic triad of cells, materials, and biochemical factors. In this perspective, we highlight ways in which these elements can be manipulated or stimulated using a fourth component: the application of remote fields. This arena has gained great momentum over the last few years, with a r ...
DOI:
10.1016/j.tibtech.2019.07.005
PubMed:
31439372
PubMed Central:
PMC7023978

3. Important methodological aspects that should be taken into account during the research of isolated mitochondria

Author:
Rendon, Dairo A.
Source:
Analytical biochemistry 2020 v.589 pp. 113492
ISSN:
0003-2697
Subject:
animal tissues,   etc   ; fruits; mitochondria;     Show all 3 Subjects
Abstract:
... Isolated mitochondria have been widely used for the study of energetic functioning of these important cellular organelles in a physiological or pathophysiological state. This is due, on the one part, to the fact that isolated mitochondria are relatively easy to isolate from a great variety of animal tissues, and on the other part to the fact that their energetic functioning is relatively easy to s ...
DOI:
10.1016/j.ab.2019.113492

4. Bio-orthogonal click reaction-enabled highly specific in situ cellularization of tissue engineering scaffolds

Author:
Mao, Duo; Zhang, Chuangnian; Kenry,; Liu, Jing; Wang, Xiaoxiao; Li, Binhan; Yan, Hongyu; Hu, Fang; Kong, Deling; Wang, Zhihong; Liu, Bin
Source:
Biomaterials 2020 v.230 pp. 119615
ISSN:
0142-9612
Subject:
tissue engineering; tissues,   etc   ; cell viability; macrophages; medicine; polymers; survival rate;     Show all 7 Subjects
Abstract:
... Tissue engineering generally utilizes natural or synthetic scaffolds to repair or replace damaged tissues. However, due to the lack of guidance of biological signals, most of the implanted scaffolds have always suffered from poor in vivo cellularization. Herein, we demonstrate a bio-orthogonal reaction-based strategy to realize in situ specific and fast cellularization of tissue engineering scaffo ...
DOI:
10.1016/j.biomaterials.2019.119615

5. Methods to generate tissue-derived constructs for regenerative medicine applications

Author:
Paulo Zambon, Joao; Atala, Anthony; Yoo, James J.
Source:
Methods 2020 v.171 pp. 3-10
ISSN:
1046-2023
Subject:
tissue engineering; tissue scaffolds,   etc   ; mechanism of action; medicine; patients;     Show all 5 Subjects
Abstract:
... The shortage of donor organs for transplantation remains a continued problem for patients with irreversible end-stage organ failure. Tissue engineering and regenerative medicine aims to develop therapies to provide viable solutions for these patients. Use of decellularized tissue scaffolds has emerged as an attractive approach to generate tissue constructs that mimic native tissue architecture and ...
DOI:
10.1016/j.ymeth.2019.09.016

6. Imparting Functionality to the Hydrogel by Magnetic-Field-Induced Nano-assembly and Macro-response

Author:
Shi, Wei; Huang, Jin; Fang, Ruochen; Liu, Mingjie
Source:
ACS applied materials & interfaces 2020 v.12 no.5 pp. 5177-5194
ISSN:
1944-8252
Subject:
tissue engineering; tissues,   etc   ; anisotropy; hydrogels; hydrophilicity; magnetic fields; nanoparticles;     Show all 7 Subjects
Abstract:
... Hydrogels are composed of 3D hydrophilic networks with an abundance of water; they are analogous to biological soft tissues. Their unique physico-chemical properties endow hydrogels with great potential in many fields, including tissue engineering and flexible sensing. However, inadequate functionality, such as lack of rapid responsiveness, severely limits practical applications in many areas. The ...
DOI:
10.1021/acsami.9b16770

7. Engineering Heart Morphogenesis

Author:
Mandrycky, Christian J.; Williams, Nisa P.; Batalov, Ivan; El-Nachef, Danny; de Bakker, Bernadette S.; Davis, Jennifer; Kim, Deok-Ho; DeForest, Cole A.; Zheng, Ying; Stevens, Kelly R.; Sniadecki, Nathan J.
Source:
Trends in biotechnology 2020
ISSN:
0167-7799
Subject:
tissue engineering; tissues,   etc   ; heart; morphogenesis; signal transduction; stem cells;     Show all 6 Subjects
Abstract:
... Recent advances in stem cell biology and tissue engineering have laid the groundwork for building complex tissues in a dish. We propose that these technologies are ready for a new challenge: recapitulating cardiac morphogenesis in vitro. In development, the heart transforms from a simple linear tube to a four-chambered organ through a complex process called looping. Here, we re-examine heart tube ...
DOI:
10.1016/j.tibtech.2020.01.006

8. Intraoperative Bioprinting: Repairing Tissues and Organs in a Surgical Setting

Author:
Wu, Yang; Ravnic, Dino J.; Ozbolat, Ibrahim T.
Source:
Trends in biotechnology 2020 v.38 no.6 pp. 594-605
ISSN:
0167-7799
Subject:
tissues,   etc   ; bioprinting; debridement; patients; resection;     Show all 5 Subjects
Abstract:
... 3D bioprinting directly into injured sites in a surgical setting, intraoperative bioprinting (IOB), is an effective process, in which the defect information can be rapidly acquired and then repaired via bioprinting on a live subject. In patients needing tissue resection, debridement, traumatic reconstruction, or fracture repair, the ability to scan and bioprint immediately following surgical prepa ...
DOI:
10.1016/j.tibtech.2020.01.004

9. Bringing Microscopy-By-Sequencing into View

Author:
Boulgakov, Alexander A.; Ellington, Andrew D.; Marcotte, Edward M.
Source:
Trends in biotechnology 2020 v.38 no.2 pp. 154-162
ISSN:
0167-7799
Subject:
tissues,   etc   ; DNA barcoding; crosslinking; light;     Show all 4 Subjects
Abstract:
... The spatial distribution of molecules and cells is fundamental to understanding biological systems. Traditionally, microscopies based on electromagnetic waves such as visible light have been used to localize cellular components by direct visualization. However, these techniques suffer from limitations of transmissibility and throughput. Complementary to optical approaches, biochemical techniques s ...
DOI:
10.1016/j.tibtech.2019.06.001
PubMed:
31416630
PubMed Central:
PMC6943198

10. Regrowing the damaged or lost body parts

Author:
Shanmukhan, Anju Pallipurath; Mathew, Mabel Maria; Radhakrishnan, Dhanya; Aiyaz, Mohammed; Prasad, Kalika
Source:
Current opinion in plant biology 2020 v.53 pp. 117-127
ISSN:
1369-5266
Subject:
tissues,   etc   ; plant organs; root tips;     Show all 3 Subjects
Abstract:
... Plants display extraordinary ability to revive tissues and organs lost or damaged in injury. This is evident from the root tip restoration and classical experiments in stem demonstrating re-establishment of vascular continuity. While recent studies have begun to unravel the mechanistic understanding of tissue restoration in response to injury in underground plant organs, the molecular mechanisms o ...
DOI:
10.1016/j.pbi.2019.12.007

11. A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering

Author:
Calejo, Isabel; Costa-Almeida, Raquel; Reis, Rui L.; Gomes, Manuela E.
Source:
Trends in biotechnology 2020 v.38 no.1 pp. 83-98
ISSN:
0167-7799
Subject:
tissue engineering; tissue repair; tissues,   etc   ; biocompatible materials; musculoskeletal diseases; musculoskeletal system;     Show all 6 Subjects
Abstract:
... Musculoskeletal diseases are increasing the prevalence of physical disability worldwide. Within the body, musculoskeletal soft and hard tissues integrate through specific multitissue transitions, allowing for body movements. Owing to their unique compositional and structural gradients, injuries challenge the native interfaces and tissue regeneration is unlikely to occur. Tissue engineering strateg ...
DOI:
10.1016/j.tibtech.2019.06.003

12. Electric Phenomenon: A Disregarded Tool in Tissue Engineering and Regenerative Medicine

Author:
da Silva, Lucília P.; Kundu, Subhas C.; Reis, Rui L.; Correlo, Vitor M.
Source:
Trends in biotechnology 2020 v.38 no.1 pp. 24-49
ISSN:
0167-7799
Subject:
tissue engineering; tissue repair; tissues,   etc   ; biocompatible materials; electric field; electrical treatment; electrophysiology; hearing; humans; medicine; muscle contraction; synapse;     Show all 12 Subjects
Abstract:
... Tissue engineering and regenerative medicine (TERM) are paving the way to the generation of functional and mature biological tissues that closely emulate cellular, biochemical, and mechanical cues. Electrical fields in the human body modulate myriad biological processes, such as synapses, muscle contraction, hearing, and wound healing, which were disregarded in TERM until recently. To preserve and ...
DOI:
10.1016/j.tibtech.2019.07.002

13. Influence of bullet type and muzzle-to-target distance on trajectory deflection through a soft tissue simulant

Author:
Kerkhoff, W.; Mattijssen, E.J.A.T.; Riva, F.
Source:
Forensic science international 2020 v.311 pp. 110289
ISSN:
0379-0738
Subject:
tissues,   etc   ; animal injuries; forensic sciences; gelatin;     Show all 4 Subjects
Abstract:
... The influence of two different variables on deflection was studied with 9mm Luger calibre bullets, fired through ballistic gelatine. To test whether bullet type affects trajectory deflection, bullets of four different types were fired (20 shots per type) through 25cm of 10% gelatine at a 5m muzzle-to target-distance. A Kruskal-Wallis test showed that the deflection of at least one bullet type was ...
DOI:
10.1016/j.forsciint.2020.110289

14. Effect of auriculopalpebral nerve block on equine intraocular pressure measured by rebound tonometry (TonoVet®)

Author:
Diehl, Kathryn; Bowden, Anna Catherine
Source:
Veterinary ophthalmology 2020 v.23 no.2 pp. 368-373
ISSN:
1463-5216
Subject:
nerve tissue,   etc   ; eyes; horses; models; ophthalmology;     Show all 5 Subjects
Abstract:
... OBJECTIVE: To assess rebound tonometry intraocular pressure (IOP) in unsedated horses without and with auriculopalpebral (AP) nerve blocks. ANIMALS STUDIED: Twenty‐two client‐ and twenty university‐owned horses (84 total eyes) with unremarkable ophthalmic examinations were evaluated. PROCEDURE: One eye of each horse was chosen randomly, an AP block performed for that eye, and IOP measured in both ...
DOI:
10.1111/vop.12735

15. Leveling Up Hydrogels: Hybrid Systems in Tissue Engineering

Author:
Neves, Sara C.; Moroni, Lorenzo; Barrias, Cristina C.; Granja, Pedro L.
Source:
Trends in biotechnology 2020 v.38 no.3 pp. 292-315
ISSN:
0167-7799
Subject:
tissue engineering,   etc   ; hydrogels; manmade structures; medicine;     Show all 4 Subjects
Abstract:
... Hydrogels can mimic several features of the cell native microenvironment and have been widely used as synthetic extracellular matrices (ECMs) in tissue engineering and regenerative medicine (TERM). However, some applications have specifications that hydrogels cannot efficiently fulfill on their own. Incorporating reinforcing structures like fibrous scaffolds or particles into hydrogels, as hybrid ...
DOI:
10.1016/j.tibtech.2019.09.004

16. Origin and distribution of the brachial plexus of the Van cats

Author:
Hakkı Nur, İsmail; Keleş, Hacı; Pérez, William
Source:
Anatomia, histologia, embryologia 2020 v.49 no.2 pp. 251-259
ISSN:
0340-2096
Subject:
nerve tissue,   etc   ; cats; neck; plexus; surgery;     Show all 5 Subjects
Abstract:
... Knowing the structure and variations of the plexus brachialis is important in neck and shoulder surgery. The knowledge of the brachial plexus reduces the injury rate of the nerves in surgical interventions to the axillary region. The major nerve trunks of the thoracic limb were the suprascapular, subscapular, axillary, radial, musculocutaneous, median and ulnar nerves. In Van cats, the brachial pl ...
DOI:
10.1111/ahe.12523

17. Decellularized ECM-derived bioinks: Prospects for the future

Author:
Kabirian, Fatemeh; Mozafari, Masoud
Source:
Methods 2020 v.171 pp. 108-118
ISSN:
1046-2023
Subject:
tissue engineering,   etc   ; bioprinting; extracellular matrix; patients; ultrastructure;     Show all 5 Subjects
Abstract:
... Decellularization aims to remove cells from tissue ultrastructure while preserving the mechanical and biological properties, which makes the decellularized extracellular matrix (dECM) an appropriate scaffold for tissue engineering applications. Three-dimensional (3D) bioprinting technology as a reproducible and accurate method can print the combination of ECM and autologous cells layer by layer to ...
DOI:
10.1016/j.ymeth.2019.04.019

18. Effect of 3% chloroprocaine hydrochloride when used for median and ulnar regional nerve blocks in lame horses

Author:
Boone, Lindsey H.; DeGraves, Fred J.; Klein, Chelsea E.; Cole, Robert C.; Schumacher, John
Source:
American journal of veterinary research 2020 v.81 no.1 pp. 13-16
ISSN:
0002-9645
Subject:
nerve tissue,   etc   ; analgesia; horses; lameness; veterinary medicine;     Show all 5 Subjects
Abstract:
... OBJECTIVE To assess onset of analgesia for 3% chloroprocaine hydrochloride and 2% mepivacaine hydrochloride when used for median and ulnar nerve blocks in lame horses. ANIMALS 6 naturally lame horses. PROCEDURES A crossover experiment was conducted. Horses were assigned to 1 of 2 treatment groups (3% chloroprocaine or 2% mepivacaine first). Median and ulnar nerve blocks were performed in the lame ...
DOI:
10.2460/ajvr.81.1.13

19. Ultrasonographic study of a modified axillary approach to block the major branches of the brachial plexus in dogs

Author:
da Silva, Luciano CBA.; Futema, Fábio; Cortopassi, Silvia RG.
Source:
Veterinary anaesthesia and analgesia 2020 v.47 no.1 pp. 82-87
ISSN:
1467-2987
Subject:
nerve tissue,   etc   ; cadaver; dogs; plexus; ultrasonography;     Show all 5 Subjects
Abstract:
... To provide ultrasonographic mapping of the axillary region of dogs to facilitate identification of the major branches of the brachial plexus in relation to the axillary artery.Prospective study.A total of two dog cadavers and 50 client-owned, healthy dogs weighing >15 kg.In Phase 1, anatomical dissections were performed to identify the relation of the major brachial plexus nerves to the axillary a ...
DOI:
10.1016/j.vaa.2019.07.002

20. An insight on type I collagen from horse tendon for the manufacture of implantable devices

Author:
Salvatore, Luca; Gallo, Nunzia; Aiello, Donatella; Lunetti, Paola; Barca, Amilcare; Blasi, Laura; Madaghiele, Marta; Bettini, Simona; Giancane, Gabriele; Hasan, Mohammed; Borovkov, Victor; Natali, Maria L.; Campa, Lorena; Valli, Ludovico; Capobianco, Loredana; Napoli, Anna; Sannino, Alessandro
Source:
International journal of biological macromolecules 2020 v.154 pp. 291-306
ISSN:
0141-8130
Subject:
animal tissues; tissue engineering,   etc   ; collagen; horses; humans; immune response; manufacturing; risk; zoonoses;     Show all 9 Subjects
Abstract:
... Type I collagen is the most abundant protein of the human body. Due to its favourable properties, collagen extracted from animal tissues is adopted to manufacture a wide range of devices for biomedical applications. Compared to bovine and porcine collagens, which are the most largely used, equine collagen is free from the risk of zoonosis, has no reported immune reactions, and has not religious co ...
DOI:
10.1016/j.ijbiomac.2020.03.082