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1. Persistent Mercury Contamination in Shooting Range Soils: The Legacy from Former Primers

Author:
Stauffer, M.; Pignolet, A.; Corcho Alvarado, J. A.
Source:
Bulletin of environmental contamination and toxicology 2017 v.98 no.1 pp. 14-21
ISSN:
0007-4861
Subject:
toxicity,   etc   ; mercury; soil; Switzerland;     Show all 4 Subjects
Abstract:
... Mercury (Hg) compounds were used in the past in primers for rifle and handgun ammunition. Despite its toxicity, little is known about the contamination of shooting-range soils with this metal. We present new data about the Hg contamination of surface soils from numerous shooting ranges of Switzerland. Our study demonstrates that Hg is measurable at high levels in surface soils from the shooting ra ...
DOI:
10.1007/s00128-016-1976-3

2. Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

Author:
Lucato, Christina M.; Lupton, Christopher J.; Halls, Michelle L.; Ellisdon, Andrew M.
Source:
Journal of Molecular Biology 2017
ISSN:
0022-2836
Subject:
toxicity,   etc   ; amyloid; protein folding;     Show all 3 Subjects
Abstract:
... The misfolding of proteins to form amyloid is a key pathological feature of several progressive, and currently incurable, diseases. A mechanistic understanding of the pathway from soluble, native protein to insoluble amyloid is crucial for therapeutic design, and recent efforts have helped to elucidate the key molecular events that trigger protein misfolding. Generally, either global or local stru ...
DOI:
10.1016/j.jmb.2017.03.021

3. Efficacy of dacarbazine as a rescue agent for histiocytic sarcoma in dogs

Author:
Kezer, K. A.; Barber, L. G.; Jennings, S. H.
Source:
Veterinary and comparative oncology 2018 v.16 no.1 pp. 4-80
ISSN:
1476-5810
Subject:
toxicity,   etc   ; dogs; medical records; metastasis; prognosis; remission; sarcoma; therapeutics;     Show all 8 Subjects
Abstract:
... BACKGROUND: Canine histiocytic sarcoma (HS) is an aggressive neoplasm that is generally associated with a poor prognosis. CCNU is considered first‐line medical therapy, although the majority of dogs ultimately develop progressive disease. The objective of this study was to evaluate the efficacy of dacarbazine as a rescue agent for HS. MATERIALS AND METHODS: Medical records of dogs diagnosed with H ...
DOI:
10.1111/vco.12314

4. Understanding and manipulating luminescence in carbon nanodots

Author:
Su, Z.C.; Ye, H.G.; Xiong, Z.; Lou, Q.; Zhang, Z.; Tang, F.; Tang, J.Y.; Dai, J.Y.; Shan, C.X.; Xu, S.J.
Source:
Carbon 2018 v.126 pp. 58-64
ISSN:
0008-6223
Subject:
toxicity,   etc   ; biocompatibility; carbon; color; luminescence; nanomaterials; nitrogen; spectroscopy;     Show all 8 Subjects
Abstract:
... Carbon nanodots (CDs), a new star in the carbon nanomaterials family, have been demonstrated to show strong luminescence, and can meet the needs of large-scale production for biological and medical applications due to their low toxicity and biocompatibility. However, their luminescence mechanisms, such as color tuning and strong excitation-dependent luminescence, are still unclear. Herein, we pres ...
DOI:
10.1016/j.carbon.2017.10.013

5. Burrowing behavior of Chironomus yoshimatsui larvae as an indicator of freshwater quality

Author:
Mo, Hyoung-ho; Son, Jino; Ryoo, Keon-Sang; Bae, Yeon Jae; Cho, Kijong
Source:
Ecological indicators 2018 v.85 pp. 377-382
ISSN:
1470-160X
Subject:
acute toxicity; toxicity testing,   etc   ; Chironomus; burrowing; cadmium; chemical analysis; ecotoxicology; industrial sites; larvae; sand; streams; water quality; Korean Peninsula;     Show all 13 Subjects
Abstract:
... A new behavioral endpoint in ecotoxicity testing, burrowing behavior of Chironomus yoshimatsui larvae that survived pre-exposure to 0, 1, 5, and 10mg/L of cadmium for 96h was evaluated in a system composed of clean reconstituted water and sand for 5h, at 30min intervals. The effective time required for 50% of the introduced larvae to burrow (ET50), the proportion of the maximum burrowing rate reac ...
DOI:
10.1016/j.ecolind.2017.10.067

6. Inducing pollution prevention adoption: effectiveness of the 33/50 voluntary environmental program

Author:
Bi, Xiang; Khanna, Madhu
Source:
Journal of environmental planning and management 2017 v.60 no.12 pp. 2234-2254
ISSN:
1360-0559
Subject:
toxicity,   etc   ; environmental programs; pollution control;     Show all 3 Subjects
Abstract:
... The Environmental Protection Agency has encouraged voluntary efforts at pollution prevention by facilities through participation in voluntary environmental programs (VEPs) such as the 33/50 program to reduce toxic releases. This paper examines the effectiveness of the 33/50 program in the adoption of pollution prevention practices and disentangles the effect of adoption from that of program partic ...
DOI:
10.1080/09640568.2016.1273099

7. Microscopic evaluation of the ventricular tissue using stereological and Voronoi tessellation methods: Application on doxorubicin-induced cardiotoxicity in rats

Author:
Rafati, Ali; Jafarinezhad, Zahra; Karbalay-Doust, Saied; Hosseini, Leila; Noorafshan, Ali
Source:
Micron 2017 v.101 pp. 1-7
ISSN:
0968-4328
Subject:
toxicity,   etc   ; cardiomyocytes; covariance; doxorubicin; rats;     Show all 5 Subjects
Abstract:
... There is limited quantitative microscopic information concerning the three-dimensional arrangement of cardiomyocytes and microvessels in cardiotoxic condition. The aim of this study was to evaluate the cardiac tissue of rats under different experimental conditions using modern second-order stereology and Voronoi tessellation techniques to show the spatial arrangement of the cardiomyocytes and micr ...
DOI:
10.1016/j.micron.2017.05.004

8. Solution-Processed Cesium Hexabromopalladate(IV), Cs2PdBr6, for Optoelectronic Applications

Author:
Sakai, Nobuya; Haghighirad, Amir Abbas; Filip, Marina R.; Nayak, Pabitra K.; Nayak, Simantini; Ramadan, Alexandra; Wang, Zhiping; Giustino, Feliciano; Snaith, Henry J.
Source:
Journal of the American Chemical Society 2017 v.139 no.17 pp. 6030-6033
ISSN:
1520-5126
Subject:
toxicity,   etc   ; cesium; commercialization; methodology; photoluminescence;     Show all 5 Subjects
Abstract:
... Lead halide perovskites are materials with excellent optoelectronic and photovoltaic properties. However, some hurdles remain prior to commercialization of these materials, such as chemical stability, phase stability, sensitivity to moisture, and potential issues due to the toxicity of lead. Here, we report a new type of lead-free perovskite related compound, Cs₂PdBr₆. This compound is solution pr ...
DOI:
10.1021/jacs.6b13258

9. An ultrasensitive fluorescent probe for rapid determination of thiophenols

Author:
Lin, Lin; Zeng, Xiangqiong; Shen, Yuning; Zhu, Hailiang; Qian, Yong
Source:
Talanta 2017 v.165 pp. 321-325
ISSN:
0039-9140
Subject:
toxicity,   etc   ; fluorescence; fluorescent dyes; thiols;     Show all 4 Subjects
Abstract:
... An ultrasensitive fluorescent probe TPP was developed for the highly selective detection of thiophenols based on excited-state intramolecular proton transfer (ESIPT) mechanism, its synthesis through a simple straightforward combination of HBT fluorophore with 2,4-dinitrobenzene functional group. A kinetic study of TPP towards thiophenol displayed a fast response time (~150s) and significant turn-o ...
DOI:
10.1016/j.talanta.2016.12.074

10. Effects of short- and long-term exposures to copper on lethal and reproductive endpoints of the harpacticoid copepod Tigriopus fulvus

Author:
Biandolino, Francesca; Parlapiano, Isabella; Faraponova, Olga; Prato, Ermelinda
Source:
Ecotoxicology and environmental safety 2018 v.147 pp. 327-333
ISSN:
0147-6513
Subject:
chronic toxicity; toxicity testing,   etc   ; Tigriopus; chronic exposure; copper; ecotoxicology; fecundity; geographical distribution; hatching; larval development; median effective concentration; models; molting; nauplii; neonates; pollutants; sex ratio; toxic substances;     Show all 18 Subjects
Abstract:
... The long-term exposure provides a realistic measurement of the effects of toxicants on aquatic organisms.The harpacticoid copepod Tigriopus fulvus has a wide geographical distribution and is considered as an ideal model organism for ecotoxicological studies for its good sensitivity to different toxicants.In this study, acute, sub-chronic and chronic toxicity tests based on lethal and reproductive ...
DOI:
10.1016/j.ecoenv.2017.08.041

11. Evolutionary engineering improves tolerance for medium-chain alcohols in Saccharomyces cerevisiae

Author:
Davis López, StephanieA.; Griffith, DouglasAndrew; Choi, Brian; Cate, JamieH. D.; Tullman-Ercek, Danielle
Source:
Biotechnology for biofuels 2018 v.11 no.1 pp. 1-90
ISSN:
1754-6834
Subject:
toxicity,   etc   ; Saccharomyces cerevisiae; biofuels; butanol; cost effectiveness; engineering; guanine; mutation; pentanols; petroleum; proteins; translation (genetics);     Show all 12 Subjects
Abstract:
... BACKGROUND: Yeast-based chemical production is an environmentally friendly alternative to petroleum-based production or processes that involve harsh chemicals. However, many potential alcohol biofuels, such as n-butanol, isobutanol and n-hexanol, are toxic to production organisms, lowering the efficiency and cost-effectiveness of these processes. We set out to improve the tolerance of Saccharomyce ...
DOI:
10.1186/s13068-018-1089-9

12. Flow cytometry analysis of Clostridium beijerinckii NRRL B-598 populations exhibiting different phenotypes induced by changes in cultivation conditions

Author:
Branska, Barbora; Pechacova, Zora; Kolek, Jan; Vasylkivska, Maryna; Patakova, Petra
Source:
Biotechnology for biofuels 2018 v.11 no.1 pp. 1-99
ISSN:
1754-6834
Subject:
toxicity,   etc   ; Clostridium beijerinckii; butanol; fermentation; flow cytometry; metabolites; pH; phenotype; propidium; screening; solvents; sporulation; staining; viability;     Show all 14 Subjects
Abstract:
... BACKGROUND: Biobutanol production by clostridia via the acetone–butanol–ethanol (ABE) pathway is a promising future technology in bioenergetics , but identifying key regulatory mechanisms for this pathway is essential in order to construct industrially relevant strains with high tolerance and productivity. We have applied flow cytometric analysis to C. beijerinckii NRRL B-598 and carried out compa ...
DOI:
10.1186/s13068-018-1096-x

13. Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities

Author:
Belfiore, Lisa; Saunders, Darren N.; Ranson, Marie; Thurecht, Kristofer J.; Storm, Gert; Vine, Kara L.
Source:
Journal of controlled release 2018 v.277 pp. 13-13
ISSN:
0168-3659
Subject:
toxicity,   etc   ; antineoplastic activity; drug carriers; drug formulations; drugs; ligands; models; neoplasm cells; neoplasms; receptors; stromal cells;     Show all 11 Subjects
Abstract:
... The development of therapeutic resistance to targeted anticancer therapies remains a significant clinical problem, with intratumoral heterogeneity playing a key role. In this context, improving the therapeutic outcome through simultaneous targeting of multiple tumor cell subtypes within a heterogeneous tumor is a promising approach. Liposomes have emerged as useful drug carriers that can reduce sy ...
DOI:
10.1016/j.jconrel.2018.02.040

14. Risk assessment of pyrrolizidine alkaloids in food of plant and animal origin

Author:
Dusemund, Birgit; Nowak, Nicole; Sommerfeld, Christine; Lindtner, Oliver; Schäfer, Bernd; Lampen, Alfonso
Source:
Food and chemical toxicology 2018 v.115 pp. 10-72
ISSN:
0278-6915
Subject:
chronic toxicity,   etc   ; carcinogenicity; dietary supplements; foods; genotoxicity; hepatotoxicity; herbal tea; herbs; humans; models; riddelliine; risk; toxicology;     Show all 13 Subjects
Abstract:
... Acute liver toxicity, specifically in the form of hepatic veno-occlusive disease (HVOD), is known from reports on human poisonings following ingestions of 1,2-unsaturated pyrrolizidine alkaloids (PAs) containing herbs. Recently PA exposure via common foods contaminated via PA-producing plants raised concern, especially regarding the potential of genotoxicity and carcinogenicity. The health risks r ...
DOI:
10.1016/j.fct.2018.03.005

15. Readily prepared biodegradable nanoparticles to formulate poorly water soluble drugs improving their pharmacological properties: The example of trabectedin

Author:
Capasso Palmiero, Umberto; Morosi, Lavinia; Bello, Ezia; Ponzo, Marianna; Frapolli, Roberta; Matteo, Cristina; Ferrari, Mariella; Zucchetti, Massimo; Minoli, Lucia; De Maglie, Marcella; Romanelli, Pierpaolo; Morbidelli, Massimo; D'Incalci, Maurizio; Moscatelli, Davide
Source:
Journal of controlled release 2018 v.276 pp. 10-149
ISSN:
0168-3659
Subject:
toxicity,   etc   ; antineoplastic activity; antineoplastic agents; biodegradability; cost effectiveness; drug formulations; injection site; medicine; nanoparticles; polymerization;     Show all 10 Subjects
Abstract:
... The improvement of the pharmacological profile of lipophilic drug formulations is one of the main successes achieved using nanoparticles (NPs) in medicine. However, the complex synthesis procedure and numerous post-processing steps hamper the cost-effective use of these formulations. In this work, an approach which requires only a syringe to produce self-assembling biodegradable and biocompatible ...
DOI:
10.1016/j.jconrel.2018.03.005

16. Chemotherapeutic drug delivery by tumoral extracellular matrix targeting

Author:
Raavé, René; van Kuppevelt, Toin H.; Daamen, Willeke F.
Source:
Journal of controlled release 2018 v.274 pp. 8-8
ISSN:
0168-3659
Subject:
toxicity,   etc   ; antineoplastic agents; clinical trials; drug therapy; extracellular matrix; fibroblasts; macrophages; neoplasm cells; neoplasms; stem cells;     Show all 10 Subjects
Abstract:
... Systemic chemotherapy is a primary strategy in the treatment of cancer, but comes with a number of limitations such as toxicity and unfavorable biodistribution. To overcome these issues, numerous targeting systems for specific delivery of chemotherapeutics to tumor cells have been designed and evaluated. Such strategies generally address subsets of tumor cells, still allowing the progressive growt ...
DOI:
10.1016/j.jconrel.2018.01.029

17. Agrochemical lead optimization by scaffold hopping

Author:
Lamberth, Clemens
Source:
Pest management science 2018 v.74 no.2 pp. 11-292
ISSN:
1526-498X
Subject:
toxicity,   etc   ; active ingredients; agrochemicals; drugs; moieties; nitrogen; pest management; plant protection;     Show all 8 Subjects
Abstract:
... Scaffold hopping, the exchange of a specific portion of a potential active ingredient with another substructure with the aim of finding isofunctional molecular structures with significantly different molecular backbones, often offers the chance in lead discovery or optimization to mitigate problems related to toxicity, intellectual property, and insufficient potency or stability. Scaffold hopping ...
DOI:
10.1002/ps.4755

18. Catalytic reduction for water treatment

Author:
Hu, Maocong; Liu, Yin; Yao, Zhenhua; Ma, Liping; Wang, Xianqin
Source:
Frontiers of environmental science & engineering 2018 v.12 no.1 pp. 1-3
ISSN:
2095-2201
Subject:
toxicity,   etc   ; catalysts; catalytic activity; groundwater; hydrogen; hydrogenation; nitrate reduction; nitrates; nitrites; remediation; wastewater treatment; water pollution;     Show all 12 Subjects
Abstract:
... Treating water contaminants via heterogeneously catalyzed reduction reaction is a subject of growing interest due to its good activity and superior selectivity compared to conventional technology, yielding products that are non-toxic or substantially less toxic. This article reviews the application of catalytic reduction as a progressive approach to treat different types of contaminants in water, ...
DOI:
10.1007/s11783-017-0972-0

19. Determination of cyanamide residue in 21 plant-derived foods by liquid chromatography-tandem mass spectrometry

Author:
Cheng, Cheng; Di, Shanshan; Zhang, Wenjun; Chen, Li; Tian, Zhongnan; Zhou, Zhiqiang; Diao, Jinling
Source:
Food chemistry 2018 v.239 pp. 529-534
ISSN:
0308-8146
Subject:
toxicity,   etc   ; carbon nanotubes; chlorides; derivatization; green tea; liquid chromatography; pepper; plant-based foods; tandem mass spectrometry;     Show all 9 Subjects
Abstract:
... Cyanamide is widely used in agriculture, and has a modest toxicity in humans. In the present study, a simple, sensitive, and widely applicable method for detecting cyanamide in 21 plant-derived foods was developed. In the proposed method, after the samples were homogenized and extracted, the method employs clean-up with multi-walled carbon nanotubes (MWCNTs) and derivatization with dansyl chloride ...
DOI:
10.1016/j.foodchem.2017.06.146

20. Deriving freshwater safety thresholds for hexabromocyclododecane and comparison of toxicity of brominated flame retardants

Author:
Dong, Liang; Zheng, Lei; Yang, Suwen; Yan, Zhenguang; Jin, Weidong; Yan, Yuhong
Source:
Ecotoxicology and environmental safety 2017
ISSN:
0147-6513
Subject:
acute toxicity; chronic toxicity; toxicity testing,   etc   ; aquatic organisms; freshwater; freshwater ecosystems; hexabromocyclododecane; models; water quality; China; Netherlands; United States;     Show all 12 Subjects
Abstract:
... Hexabromocyclododecane (HBCD) is a brominated flame retardant used throughout the world. It has been detected in various environmental media and has been shown toxic to aquatic life. The toxic effects of HBCD to aquatic organisms in Chinese freshwater ecosystems are discussed here. Experiments were conducted with nine types of acute toxicity testing and three types of chronic toxicity testing. Aft ...
DOI:
10.1016/j.ecoenv.2017.01.005