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1. Toxic effects of magnetic nanoparticles on normal cells and organs

Author:
Jiang, Ziyu; Shan, Kuizhong; Song, Jie; Liu, Jingbing; Rajendran, Suresh; Pugazhendhi, Arivalagan; Jacob, Joe Antony; Chen, Baoan
Source:
Life sciences 2019 v.220 pp. 156-161
ISSN:
0024-3205
Subject:
toxicity,   etc   ; drugs; magnetism; nanoparticles;     Show all 4 Subjects
Abstract:
... Magnetic nanoparticles (MNPs) are promising candidates for drug delivery and treatment of various disorders. Toxicity evaluation is a critical point in the development of nanoformulations and therefore, draws considerable attention. Formulations involving individual or combinatorial nanoparticle suspensions might be used for targeted delivery and treatment. This might be a evaluated further for sa ...
DOI:
10.1016/j.lfs.2019.01.056

2. Much ado about interaction: A combination of linear processes yields non-linear toxic effects in chemical mixtures

Author:
Kamo, Masashi; Iwasaki, Yuichi; Yokomizo, Hiroyuki
Source:
Chemosphere 2019 v.219 pp. 89-94
ISSN:
0045-6535
Subject:
toxicity; toxicity testing,   etc   ; ligands; metals; models; prediction; risk assessment;     Show all 7 Subjects
Abstract:
... Predicting chemical mixture toxicity is an important issue for risk assessment. Loewe's concentration addition (CA) is a major model for predicting such toxicity. The CA is an additivity-based model, and if the results of toxicity test deviate from the CA prediction, it is considered that the toxic effect of the mixture is non-additive, and that “interaction” has played some role. In the present s ...
DOI:
10.1016/j.chemosphere.2018.11.134

3. Design, synthesis and biological activity evaluation of benzoate compounds as local anesthetics

Author:
Zou, Huiying; Chen, Guangying; Zhou, Shiyang
Source:
RSC advances 2019 v.9 no.12 pp. 6627-6635
ISSN:
2046-2069
Subject:
acute toxicity; toxicity testing,   etc   ; alkylation; anesthesia; esterification; local anesthetics; moieties;     Show all 7 Subjects
Abstract:
... Tetracaine and pramocaine were used as the lead compounds to design benzoate compounds. The combination principle was used to design the target molecule, and the target molecule was modified by bioisostere formation and modification with alkyl groups. In this research, a total of 16 compounds were designed and synthesized. In the process of synthesis, we selected a route with high total yields, mi ...
DOI:
10.1039/c9ra00476a

4. Novel approaches to derive points of departure for food chemical risk assessment

Author:
Levorato, Sara; Rietjens, Ivonne MCM; Carmichael, Paul L; Hepburn, Paul A
Source:
Current opinion in food science 2019
ISSN:
2214-7993
Subject:
toxicity; toxicity testing,   etc   ; chemical risk assessment; in vivo studies; toxicogenomics;     Show all 5 Subjects
Abstract:
... Food chemical risk assessment characterizes the potential hazards and the associated health risks resulting from exposure of humans to chemicals present in food over a specified period. This requires the identification of points of departure, which are usually derived from apical toxicity endpoints in in vivo studies. However, a shift in the traditional paradigm in toxicity testing for risk assess ...
DOI:
10.1016/j.cofs.2019.02.016

5. We might have got it wrong: Modern wheat is not more toxic for celiac patients

Author:
Ribeiro, Miguel; Nunes, Fernando M.
Source:
Food chemistry 2019 v.278 pp. 820-822
ISSN:
0308-8146
Subject:
toxicity,   etc   ; celiac disease; patients; wheat;     Show all 4 Subjects
Abstract:
... If there is a disease in which many myths are part of the daily lives of both patients and clinicians as well as researchers, this must be celiac disease. Here, we discuss the possibility that modern wheat varieties used by man do not have led to the increased prevalence of celiac disease. ...
DOI:
10.1016/j.foodchem.2018.12.003

6. Joint toxic effects of cadmium and four pesticides on the earthworm (Eisenia fetida)

Author:
Yu, Yijun; Li, Xinfang; Yang, Guiling; Wang, Yanhua; Wang, Xinquan; Cai, Leiming; Liu, Xinju
Source:
Chemosphere 2019 v.227 pp. 489-495
ISSN:
0045-6535
Subject:
soil toxicity; toxicity; toxicity testing,   etc   ; Eisenia fetida; abamectin; agrochemicals; atrazine; bioassays; cadmium; chlorpyrifos; earthworms; heavy metals; lambda-cyhalothrin; synergism;     Show all 14 Subjects
Abstract:
... The contaminants, instead of single contaminants, are usually found as chemical mixtures in terrestrial environment. However, little information is now available about the joint effects of heavy metals and farm chemicals on the soil organism. Our current study aimed to assess the combined toxicity of cadmium (Cd) and four pesticides (atrazine, chlorpyrifos, lambda-cyhalothrin and abamectin) to the ...
DOI:
10.1016/j.chemosphere.2019.04.064

7. Occurrence, toxicity, and speciation analysis of arsenic in edible mushrooms

Author:
Zou, Haimin; Zhou, Chen; Li, Yongxin; Yang, Xiaosong; Wen, Jun; Hu, Xiaoke; Sun, Chengjun
Source:
Food chemistry 2019 v.281 pp. 269-284
ISSN:
0308-8146
Subject:
toxicity,   etc   ; arsenic; biotransformation; human health; mushrooms;     Show all 5 Subjects
Abstract:
... Owing to the strong concentration and biotransformation of arsenic, the influence of some edible mushrooms on human health has attracted widespread attention. The toxicity of arsenic greatly depends on its species, so the speciation analysis of arsenic is of critical importance. The aim of the present review is to highlight recent advances in arsenic speciation analysis in edible mushrooms. We sum ...
DOI:
10.1016/j.foodchem.2018.12.103

8. Designing Structural-Color Patterns Composed of Colloidal Arrays

Author:
Kim, Jong Bin; Lee, Seung Yeol; Lee, Jung Min; Kim, Shin-Hyun
Source:
ACS applied materials & interfaces 2019 v.11 no.16 pp. 14485-14509
ISSN:
1944-8252
Subject:
toxicity,   etc   ; color; crystals; nanomaterials; optical properties; pigments;     Show all 6 Subjects
Abstract:
... Structural coloration provides a great potential for various applications due to unique optical properties distinguished from conventional pigment colors. Structural colors are nonfading, iridescent, and tunable, which is difficult to achieve with pigments. In addition, structural color is potentially less toxic than pigments. However, it is challenging to develop structural colors because elabora ...
DOI:
10.1021/acsami.8b21276

9. Stereospecific Synthesis of 1,5-Disubstituted Tetrazoles from Ketoximes via a Beckmann Rearrangement Facilitated by Diphenyl Phosphorazidate

Author:
Ishihara, Kotaro; Shioiri, Takayuki; Matsugi, Masato
Source:
Tetrahedron letters 2019
ISSN:
0040-4039
Subject:
toxicity,   etc   ; azides; chemical structure; cis-trans isomerism;     Show all 4 Subjects
Abstract:
... A novel method for the stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via the Beckmann rearrangement was developed using diphenyl phosphorazidate (DPPA) as both the oxime activator and azide source. Various ketoximes were transformed into the corresponding 1,5-disubstituted tetrazoles with exclusive trans-group migration and no E-Z isomerization of the ketoxime. This metho ...
DOI:
10.1016/j.tetlet.2019.04.014

10. Evaluation of the bio-protection mechanism in diffusive exchange permeable reactive barriers for the treatment of acid mine drainage

Author:
Torregrosa, Martin; Schwarz, Alex; Nancucheo, Ivan; Balladares, Eduardo
Source:
The Science of the total environment 2019 v.655 pp. 374-383
ISSN:
0048-9697
Subject:
toxicity,   etc   ; acid mine drainage; copper; monitoring; zinc;     Show all 5 Subjects
Abstract:
... This research studied the bio-protection mechanism based on chemical gradients in diffusive exchange permeable reactive barriers, evaluating the thickness of the reactive layers in the treatment of concentrated acid mine drainage (AMD). Six bench-scale reactors were constructed with reactive layer thicknesses of 2.5, 5, and 7.5 cm in duplicate. The reactors were first fed a sulfated solution for 5 ...
DOI:
10.1016/j.scitotenv.2018.11.083

11. Analytical progress and challenges for the detection of oxygenated polycyclic aromatic hydrocarbon transformation products in aqueous and soil environmental matrices: A review

Author:
Pulleyblank, Coren; Cipullo, Sabrina; Campo, Pablo; Kelleher, Brian; Coulon, Frederic
Source:
Critical reviews in environmental science and technology 2019 v.49 no.5 pp. 357-409
ISSN:
1547-6537
Subject:
toxicity,   etc   ; analytical methods; polycyclic aromatic hydrocarbons; soil;     Show all 4 Subjects
Abstract:
... Over the past 20 years, a growing body of research has raised concerns about the toxicity, fate, and transport of oxygenated transformation products of polycyclic aromatic hydrocarbons. Research targeting these diverse compounds in soil and water systems has been challenged by a lack of standard analytical techniques and suitable reference materials. However, recent efforts towards the consolidati ...
DOI:
10.1080/10643389.2018.1547622

12. Hitting Undruggable Targets: Viewing Stabilized Peptide Development through the Lens of Quantitative Systems Pharmacology

Author:
Atangcho, Lydia; Navaratna, Tejas; Thurber, Greg M.
Source:
Trends in biochemical sciences 2019 v.44 no.3 pp. 241-257
ISSN:
0968-0004
Subject:
toxicity,   etc   ; drugs; genome; peptides; pharmacokinetics; screening; therapeutics;     Show all 7 Subjects
Abstract:
... Stabilized peptide therapeutics have the potential to hit currently undruggable targets, dramatically expanding the druggable genome. However, major obstacles to their development include poor intracellular delivery, rapid degradation, low target affinity, and membrane toxicity. With the emergence of multiple stabilization techniques and screening technologies, the high efficacy of various bioacti ...
DOI:
10.1016/j.tibs.2018.11.008

13. Effect of hydroxypropyl-β-cyclodextrin on the cometabolism of phenol and phenanthrene by a novel Chryseobacterium sp.

Author:
Xiao, Meng; Yin, Xiangyang; Gai, Hengjun; Ma, Honglei; Qi, Yanfeng; Li, Kun; Hua, Xia; Sun, Meng; Song, Hongbing
Source:
Bioresource technology 2019 v.273 pp. 56-62
ISSN:
0960-8524
Subject:
toxicity,   etc   ; Chryseobacterium; coal; phenanthrenes; phenol; solubility; wastewater;     Show all 7 Subjects
Abstract:
... Cometabolic degradation is an effective method to remove the polycyclic aromatic hydrocarbons (PAHs) with phenol as growth substrate from coal chemical wastewater (CCW). Unfortunately, the toxicity and low solubility of PAHs always restrict their degradation. In this study, Chryseobacterium sp. H202 was firstly isolated from the aerobic segment of CCW. Then, to improve the cometabolic degradation ...
DOI:
10.1016/j.biortech.2018.10.087

14. Rational chemical doping of metal halide perovskites

Author:
ZhangThese authors contributed equally to this work., Xinyuan; Li, Lina; Sun, Zhihua; Luo, Junhua
Source:
Chemical Society reviews 2019 v.48 no.2 pp. 517-539
ISSN:
1460-4744
Subject:
toxicity,   etc   ; absorption; lead; physicochemical properties; solar energy;     Show all 5 Subjects
Abstract:
... Metal halide perovskites benefit from the combination of wide absorption, high carrier mobility, defect tolerance, moderate exciton binding energies, and versatility of solution processes, showing great promise in photovoltaics and optoelectronics. However, the issues of long-term instability and toxicity of lead are supposed to limit their further practical applications. Chemical doping of an imp ...
DOI:
10.1039/c8cs00563j

15. The flotation separation of galena and pyrite using serpentine as depressant

Author:
Feng, Bo; Zhang, Wenpu; Guo, Yutao; Wang, Tao; Luo, Guodong; Wang, Huihui; He, Guichun
Source:
Powder technology 2019 v.342 pp. 486-490
ISSN:
0032-5910
Subject:
toxicity,   etc   ; lead; potassium; powders; pyrite; serpentine;     Show all 6 Subjects
Abstract:
... Toxic inorganic depressants are commonly used in the flotation separation of polymetallic sulfide ores and it is desirable that they can be replaced by environmentally benign substances. Serpentine, a common gangue mineral encountered in complex sulfide ores, has been found to be an efficient depressant for ferric sulfide (e.g., pyrite). Serpentine was tested as a potential selective depressant in ...
DOI:
10.1016/j.powtec.2018.09.070

16. Relevance of nano- and microplastics for freshwater ecosystems: A critical review

Author:
Triebskorn, Rita; Braunbeck, Thomas; Grummt, Tamara; Hanslik, Lisa; Huppertsberg, Sven; Jekel, Martin; Knepper, Thomas P.; Krais, Stefanie; Müller, Yanina K.; Pittroff, Marco; Ruhl, Aki S.; Schmieg, Hannah; Schür, Christoph; Strobel, Claudia; Wagner, Martin; Zumbülte, Nicole; Köhler, Heinz-R.
Source:
Trends in analytical chemistry 2019 v.110 pp. 375-392
ISSN:
0165-9936
Subject:
toxicity,   etc   ; freshwater; freshwater ecosystems; humans; nanoplastics; rivers;     Show all 6 Subjects
Abstract:
... The current paper critically reviews the state-of-the-science on (1) microplastics (MP) types and particle concentrations in freshwater ecosystems, (2) MP and nanoplastics (NP) uptake and tissue translocation, (3) MP/NP-induced effects in freshwater organisms, and (4) capabilities of MP/NP to modulate the toxicity of environmental chemicals. The reviewed literature as well as new data on MP and NP ...
DOI:
10.1016/j.trac.2018.11.023

17. Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues

Author:
Pan, Yitao; Wang, Jinghua; Yeung, Leo W.Y.; Wei, Si; Dai, Jiayin
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
toxicity,   etc   ; gas chromatography; mass spectrometry; perfluorocarbons;     Show all 4 Subjects
Abstract:
... The increasingly stringent restrictions on legacy per- and polyfluoroalkyl substances (PFASs) have led to the compensatory use of new fluorinated replacements. These new compounds, hereafter referred to as emerging PFASs, continue to be discovered and are now showing ubiquity in abiotic and biotic environments. Thus, there is an urgent need for robust, yet sensitive analytical methods to determine ...
DOI:
10.1016/j.trac.2019.04.013

18. Recent trends in integrated bioprocesses: aiding and expanding microbial biofuel/biochemical production

Author:
Flores, Andrew; Wang, Xuan; Nielsen, David R
Source:
Current opinion in biotechnology 2019
ISSN:
0958-1669
Subject:
toxicity,   etc   ; biofuels; bioprocessing; biosynthesis; catalysts; synthesis;     Show all 6 Subjects
Abstract:
... Microbial biosynthesis of fuels and chemicals represents a promising route for their renewable production. Product toxicity, however, represents a common challenge limiting the efficacy of this approach. Integrated bioprocesses incorporating in situ product separation are poised to help address this intrinsic problem, but suffer their own unique shortcomings. To improve and expand the utility of t ...
DOI:
10.1016/j.copbio.2019.02.007

19. Sonocatalytic removal of ampicillin by Zn(OH)F: Effect of operating parameters, toxicological evaluation and by-products identification

Author:
Mirzaei, Amir; Haghighat, Fariborz; Chen, Zhi; Yerushalmi, Laleh
Source:
Journal of hazardous materials 2019 v.375 pp. 86-95
ISSN:
0304-3894
Subject:
toxicity; toxicity testing,   etc   ; ampicillin; byproducts; chemical oxygen demand; mineralization; sonocatalysis; tandem mass spectrometry; zinc; zinc oxide;     Show all 10 Subjects
Abstract:
... Zinc hydroxyfluoride (Zn(OH)F) sonocatalyst was prepared by using solvothermal method and was characterized by using various techniques. The sonocatalytic degradation of ampicillin (AMP) in water by sonolysis, bare ZnO and Zn(OH)F was investigated in terms of AMP removal, mineralization, detoxification of solution, and remaining by-products at the end of process. Results revealed that the sonocata ...
DOI:
10.1016/j.jhazmat.2019.04.069

20. On-line monitoring of heavy metals-related toxicity with a microbial fuel cell biosensor

Author:
Adekunle, Ademola; Raghavan, Vijaya; Tartakovsky, Boris
Source:
Biosensors & bioelectronics 2019 v.132 pp. 382-390
ISSN:
0956-5663
Subject:
toxicity; toxicity testing,   etc   ; biofilm; biosensors; drainage; heavy metals; microbial fuel cells; microorganisms; mining; monitoring;     Show all 10 Subjects
Abstract:
... This study describes an environmental biosensor for real time toxicity monitoring, which exploits high sensitivity of a microbial fuel cell (MFC) to variations in concentrations of electron donors and acceptors. Fast biosensor response to changes in total heavy metal concentration of a mining rock drainage was observed in laboratory tests with acceptable repeatability and a coefficient of determin ...
DOI:
10.1016/j.bios.2019.03.011