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transcription (genetics), etc ; Danio rerio; adults; bioaccumulation; brain; chemical analysis; flame retardants; histopathology; humans; liver; pollution; progeny; toxicity; China; Show all 14 Subjects
Abstract:
... Many environmental contaminants could be transmitted from parents and generate impairments to their progeny. The 2,4,6-tribromophenol (TBP), a novel brominated flame retardant which has been frequently detected in various organisms, was supposed to be bioaccumulated and intergenerational transmitted in human beings. Previous studies revealed that TBP could disrupt thyroid endocrine system in zebra ...
transcription (genetics), etc ; Henosepilachna vigintioctopunctata; entomology; Show all 3 Subjects
Abstract:
... Henosepilachna vigintioctomaculata is one of the most serious defoliates attacking potatoes. However, studies on functional genes have greatly been limited due to the insufficiency of effective and stable endogenous references to normalize RT-qPCR data. In this report, nine housekeeping genes (RPL4, RPL6, RPL13, RPL32, RPS18, ACT, EF1α, GAPDH and α-TUB) involved in different biological processes w ...
transcription (genetics), etc ; HIV infections; chromatin; proviruses; Show all 4 Subjects
Abstract:
... The shock-and-kill strategy reactivates HIV-1 latent reservoir for immune clearance. Einkauf et al. found that some HIV-1-infected cells that persist and proliferate have transcriptionally active HIV-1 in permissive chromatin. Silent proviruses in repressive chromatin resist reactivation. Understanding HIV-1-chromatin interactions and how transcriptionally active HIV-1-infected cells survive is a ...
Esdras Corrêa Dos Santos; Ariane Lalonde-Larue; Alfredo Quites Antoniazzi; Marcos Henrique Barreta; Christopher A. Price; Paulo Bayard Dias Gonçalves; Valério Marques Portela; Gustavo Zamberlam
transcription (genetics), etc ; cows; ovulation; phosphorylation; ultrasonics; Show all 5 Subjects
Abstract:
... Failure to ovulate is a major cause of infertility. The critical pathway that induces ovulation involves the EGF and MAPK phosphorylation, but studies in rodents have suggested that the Hippo activator, YAP, is also involved. It is unknown whether YAP-dependent transcriptional activity is important for the LH- or EGF-induced ovulatory cascade in monovulatory species such as the cow. Using a well-d ...
transcription (genetics), etc ; adults; fibrosis; metastasis; microRNA; plasticity; Show all 6 Subjects
Abstract:
... The dynamic transition between epithelial-like and mesenchymal-like cell states has been a focus for extensive investigation for decades, reflective of the importance of Epithelial-Mesenchymal Transition (EMT) through development, in the adult, and the contributing role EMT has to pathologies including metastasis and fibrosis. Not surprisingly, regulation of the complex genetic networks that under ...
transcription (genetics), etc ; DNA; cell nucleus; condensates; mitochondria; separation; Show all 6 Subjects
Abstract:
... Phase separation underlies the formation of biomolecular condensates. We hypothesize the cellular processes that occur within condensates shape their structural features. We use the example of transcription to discuss structure–function relationships in condensates. Various types of transcriptional condensates have been reported across the evolutionary spectrum in the cell nucleus as well as in mi ...
transcription (genetics), etc ; biogenesis; cytoskeleton; plant tissues; plasma membrane; Show all 5 Subjects
Abstract:
... The membranes of plant cells serve diverse physiological roles, which are defined largely by the localized and dynamic recruitment of proteins. Signaling lipids, such as phosphoinositides, can aid protein recruitment to the plasma membrane via specific recognition of their head groups and influence vesicular trafficking, cytoskeletal dynamics and other processes, with ramifications for plant tissu ...
transcription (genetics), etc ; chromatin; epigenetics; fruits; genome; neoplasms; therapeutics; Show all 7 Subjects
Abstract:
... The molecular characterization of mechanisms underlying transcriptional control and epigenetic inheritance since the 1990s has paved the way for the development of targeted therapies that modulate these pathways. In the past two decades, cancer genome sequencing approaches have uncovered a plethora of mutations in chromatin modifying enzymes across tumor types, and systematic genetic screens have ...
transcription (genetics), etc ; cell lines; humans; interphase; myoblasts; transcriptome; Show all 6 Subjects
Abstract:
... Satellite cells are generally quiescent in vivo. Once activated, progression through the cell cycle begins. Immortalised myoblasts from a single cell line are fairly homogenous in culture, but primary human myoblasts (PHMs) demonstrate heterogeneity. This phenomenon is poorly understood however may impact on PHM expansion. This study aimed to evaluate cell cycle transition from growth to synthesis ...
transcription (genetics), etc ; Arabidopsis; Citrus; phylogeny; sequence alignment; transcription factors; Show all 6 Subjects
Abstract:
... PISTILLATA (PI), as a member of MADS-box transcription factor, plays an important role in petal and stamen specification in Arabidopsis. However, little is known about PI-like genes in citrus. To understand the molecular mechanism of PI during the developmental process of citrus flower, a PI-like gene CcMADS20 was isolated from Citrus Clemantina. Sequence alignment and phylogenetic analysis reveal ...
transcription (genetics), etc ; algorithms; bone marrow; data collection; genome; humans; Show all 6 Subjects
Abstract:
... Scaling scRNA-seq to profile millions of cells is crucial for constructing high-resolution maps of transcriptional manifolds. Current analysis strategies, in particular dimensionality reduction and two-phase clustering, offer only limited scaling and sensitivity to define such manifolds. We introduce Metacell-2, a recursive divide-and-conquer algorithm allowing efficient decomposition of scRNA-seq ...
transcription (genetics), etc ; biomarkers; biotechnology; data visualization; databases; exercise; humans; Show all 7 Subjects
Abstract:
... With advances in NGS technologies, transcriptional profiling of human tissue across many diseases is becoming more routine, leading to the generation of petabytes of data deposited in public repositories. There is a need for bench scientists with little computational expertise to be able to access and mine this data to understand disease pathology, identify robust biomarkers of disease and the eff ...
transcription (genetics), etc ; gene expression; gene regulatory networks; genes; genomics; Show all 5 Subjects
Abstract:
... Not all transcribed RNAs are protein-coding. Some non-coding RNAs (ncRNAs) seem to be non-functional and are resulted from spurious transcription. Many others have a significant function in the translation process. Gene expressions depend on complex networks of diverse gene regulatory pathways. Several ncRNAs, as major elements, regulate gene expression in a sequence-specific system either at the ...
transcription (genetics), etc ; biosynthesis; chromosomes; food chemistry; plantaricins; plasmids; transcriptome; Show all 7 Subjects
Abstract:
... Whole-genome and transcriptome sequences of Lactiplantibacillus plantarum 163 are provided. There was one circular chromosome and four circular plasmids, with sizes of 3,131,367; 56,674; 49,140; 43,628; and 36,387 bp, respectively, in L. plantarum 163. The regulator Lp_2642 was selected from the genome data, the overexpression of which increased the transcriptional levels of related genes in plant ...
transcription (genetics), etc ; alleles; calcitriol; genotype; meta-analysis; systematic review; Show all 6 Subjects
Abstract:
... The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs ...
transcription (genetics), etc ; chromatin; gene expression; histone code; mammals; neurophysiology; transcriptome; Show all 7 Subjects
Abstract:
... In recent years, there has been an increase in research efforts surrounding RNA modification thanks to key breakthroughs in NGS-based whole transcriptome mapping methods. More than 100 modifications have been reported in RNAs, and some have been mapped at single-nucleotide resolution in the mammalian transcriptome. This has opened new research avenues in fields such as neurobiology, developmental ...
transcription (genetics), etc ; Bombyx mori; insect biochemistry; mutation; physiology; transcription factors; Show all 6 Subjects
Abstract:
... A G‐quadruplex (G4) was identified in the promoter of transcription factor BmPOUM2 in Bombyx mori. This G4 structure contains three loops and is bound by transcription factor BmLARK, facilitating the transcription of BmPOUM2. However, the relationship between the structure and function of the BmPOUM2 G4 remains to be clarified. In this study, loop mutants of the BmPOUM2 G4 structure were generated ...
transcription (genetics), etc ; Oryza sativa; cultivars; flooding tolerance; genes; rice; submergence; Show all 7 Subjects
Abstract:
... We screened 80 Asian rice (Oryza sativa L.) cultivars for the presence of the submergence-tolerance gene SUB1A-1 and the floating genes SNORKEL1 (SK1) and SNORKEL2 (SK2), and found that the deepwater rice cultivar Baisbish (BSB) and the submergence-tolerant cultivar Flood Resistant 13A (FR13A) both possess the SUB1A-1 and the SK1/2. When BSB and FR13A seedlings were completely submerged, spindly g ...
transcription (genetics), etc ; biosynthesis; gene expression; genes; p-coumaric acid; plasmids; Show all 6 Subjects
Abstract:
... Dynamic regulation has been proved efficient in controlling gene expression at transcriptional, translational, and post-translational level. However, the dynamic regulation at gene replication level has been rarely explored so far. In this study, we established dynamic regulation at gene copy level through engineering controllable plasmid replication to dynamically control the gene expression. Pro ...
transcription (genetics), etc ; Holstein; blood; gene expression; messenger RNA; molecular biology; Show all 6 Subjects
Abstract:
... BACKGROUND: High quality and quantity of messenger RNA (mRNA) are required for accuracy of gene expression studies and other RNA-based downstream applications. Since RNA is considered a labile macromolecular prone to degradation, which may result in falsely altered gene expression patterns, several commercial stabilizing reagents have been developed aiming to keep RNA stable for long period. Howev ...