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1. IRF1 negatively regulates NF-κB signaling by targeting MyD88 for degradation in teleost fish

Author:
Xuan, Meihua; Yan, Xiaolong; Liu, Xuezhu; Xu, Tianjun
Source:
Developmental and comparative immunology 2020 v.110 pp. 103709
ISSN:
0145-305X
Subject:
transcription factor NF-kappa B,   etc   ; Miichthys miiuy; fish; interferon regulatory factors; signal transduction;     Show all 5 Subjects
Abstract:
... MyD88 is considered as one of the most crucial adaptors in TLR signaling pathway. MyD88 may be influential to interferon regulatory factors (IRFs), while the way that IRFs regulate MyD88 is not fully understood. In this study, we demonstrated that the member of IRF family named IRF1 in miiuy croaker played a role as a negative regulator of MyD88-mediated NF-κB signaling and promoted the degradatio ...
DOI:
10.1016/j.dci.2020.103709

2. Synthesis of the 4-aza cyclopentenone analogue of Δ12,14-15-deoxy-PGJ2 and S-cysteine adducts

Author:
Conway, Lorna; Riccio, Anna; Santoro, M. Gabriella; Evans, Paul
Source:
Tetrahedron letters 2020 v.61 no.25 pp. 151969
ISSN:
0040-4039
Subject:
transcription factor NF-kappa B,   etc   ; chemical reactions; chemical structure; prostaglandins; thiols;     Show all 5 Subjects
Abstract:
... The synthesis of a series of 4-aza cross-conjugated cyclopentenones, inspired by the natural prostaglandin Δ¹²,¹⁴-15-deoxy-PGJ₂ (5) is described. Using the 4-aza cyclopentenone 7, the installation of the α-side chain was performed using N-functionalisation, following a Boc-deprotection. The ω-side chain was then installed through a Baylis-Hillman type aldol reaction with trans-2-octenal. This affo ...
DOI:
10.1016/j.tetlet.2020.151969

3. Mechanism and implications of morphogen shuttling: Lessons learned from dorsal and Cactus in Drosophila

Author:
Schloop, Allison E.; Carrell-Noel, Sophia; Friedman, Jeramey; Thomas, Alexander; Reeves, Gregory T.
Source:
Developmental biology 2020 v.461 no.1 pp. 13-18
ISSN:
0012-1606
Subject:
transcription factor NF-kappa B,   etc   ; Drosophila; cacti and succulents; embryo (animal); facilitated diffusion; viability;     Show all 6 Subjects
Abstract:
... In a developing animal, morphogen gradients act to pattern tissues into distinct domains of cell types. However, despite their prevalence in development, morphogen gradient formation is a matter of debate. In our recent publication, we showed that the Dorsal/NF-κB morphogen gradient, which patterns the DV axis of the early Drosophila embryo, is partially established by a mechanism of facilitated d ...
DOI:
10.1016/j.ydbio.2020.01.011

4. IRF3 enhances NF-κB activation by targeting IκBα for degradation in teleost fish

Author:
Zhao, Xueyan; Yan, Xiaolong; Huo, Ruixuan; Xu, Tianjun
Source:
Developmental and comparative immunology 2020 v.106 pp. 103632
ISSN:
0145-305X
Subject:
transcription factor NF-kappa B,   etc   ; IKappaB kinase; adaptive immunity; fish; mammals; signal transduction; ubiquitination;     Show all 7 Subjects
Abstract:
... Tightly regulation of NF-κB signaling is essential to innate and adaptive immune responses, but its regulatory mechanism remains unclear in various organisms, especially teleost fish. In this study, we reported that IRF3 attenuates the inhibitory effect of IκBα on NF-κB activation in teleost fish. Overexpression of IRF3 can promote IκBα degradation, whereas its knockdown can relieve degradation of ...
DOI:
10.1016/j.dci.2020.103632

5. Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation

Author:
Wu, Yuqing; Hu, Yingchao; Wang, Bingwei; Li, Sheng; Ma, Chunmei; Liu, Xue; Moynagh, Paul N.; Zhou, Jiawei; Yang, Shuo
Source:
Molecular cell 2020 v.78 no.1 pp. 42-56.e6
ISSN:
1097-2765
Subject:
transcription factor NF-kappa B,   etc   ; dopamine; genes; inflammation; macrophages; meningitis; mice; neurotransmitters; sepsis (infection); therapeutics;     Show all 10 Subjects
Abstract:
... The functional relevance and mechanistic basis of the effects of the neurotransmitter dopamine (DA) on inflammation remain unclear. Here we reveal that DA inhibited TLR2-induced NF-κB activation and inflammation via the DRD5 receptor in macrophages. We found that the DRD5 receptor, via the EFD and IYX(X)I/L motifs in its CT and IC3 loop, respectively, can directly recruit TRAF6 and its negative re ...
DOI:
10.1016/j.molcel.2020.01.022

6. The signaling relations between three adaptors of porcine C-type lectin receptor pathway

Author:
Jiang, Sen; Ao, Da; Ni, Jinghua; Chen, Nanhua; Meurens, François; Zhu, Jianzhong
Source:
Developmental and comparative immunology 2020 v.104 pp. 103555
ISSN:
0145-305X
Subject:
transcription factor NF-kappa B,   etc   ; cytoplasm; gene expression; innate immunity; lectins; receptors; swine;     Show all 7 Subjects
Abstract:
... As one family of pattern recognition receptors (PRRs), The C-type lectin receptors (CLRs) play a key role in the anti-fungal infection. The CLR pathway signaling is relayed by adaptor complex which comprises CARD9, BCL10 and MALT1. However, the relationship between these three adaptors has not been investigated. In this study, we isolated porcine CARD9, BCL10 and MALT1 and examined their signaling ...
DOI:
10.1016/j.dci.2019.103555

7. STAT5a induces endotoxin tolerance by alleviating pyroptosis in kupffer cells

Author:
Wang, Tao; Zhong, Hua; Zhang, Wenfeng; Wen, Jian; Yi, Zhujun; Li, Peizhi; Gong, Jianping
Source:
Molecular immunology 2020 v.122 pp. 28-37
ISSN:
0161-5890
Subject:
transcription factor NF-kappa B,   etc   ; Kupffer cells; endotoxins; inflammasomes; interleukin-10; interleukin-1beta; models; pyroptosis; sepsis (infection); signal transduction; transactivators;     Show all 11 Subjects
Abstract:
... Pyroptosis, a newly discovered type of programmed cell death, affects endotoxin tolerance in macrophages. However, the factors acting on the nod-like receptor 3 (Nlrp3) inflammasome and caspase1 activation to impede pyroptosis and resulting in tolerance and survival in sepsis were needed to discovered. Here, we found that signal transducer and activator of transcription 5A (STAT5a) restrains pyrop ...
DOI:
10.1016/j.molimm.2020.03.016

8. Molecular Interactions Between Components of the Circadian Clock and the Immune System

Author:
Hergenhan, Sophia; Holtkamp, Stephan; Scheiermann, Christoph
Source:
Journal of molecular biology 2020 v.432 no.12 pp. 3700-3713
ISSN:
0022-2836
Subject:
transcription factor NF-kappa B,   etc   ; acetylation; circadian clocks; circadian rhythm; genes; histones; immune system; immunity; methylation; transcription (genetics);     Show all 10 Subjects
Abstract:
... The immune system is under control of the circadian clock. Many of the circadian rhythms observed in the immune system originate in direct interactions between components of the circadian clock and components of the immune system. The main means of circadian control over the immune system is by direct control of circadian clock proteins acting as transcription factors driving the expression or rep ...
DOI:
10.1016/j.jmb.2019.12.044

9. Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway

Author:
Kumar, Ravi; Awasthi, Mansi; Sharma, Anamika; Padwad, Yogendra; Sharma, Rohit
Source:
Life sciences 2020 v.244 pp. 117346
ISSN:
0024-3205
Subject:
transcription factor NF-kappa B,   etc   ; apoptosis; berberine; cyclins; dose response; genes; humans; inflammation; lung neoplasms; neoplasm cells; therapeutics;     Show all 11 Subjects
Abstract:
... Emerging studies have shown that application of low concentration of bioactive phytomolecules can confer anti-proliferative effects on tumour cells by inducing senescence pathways. The alkaloid berberine is recognized for its anti-cancer attributes but its potential to induce senescence in tumour cells is least understood.The present work assessed the mechanisms pertaining to dose-dependent anti-p ...
DOI:
10.1016/j.lfs.2020.117346

10. Chordate PIAS proteins act as conserved repressors of the TRAF6 self-polyubiquitination

Author:
Fu, Xianan; Wang, Ruihua; Li, Mingshi; Yan, Xinyu; Huang, Huiqing; Li, Jin; Chen, Shenghui; Yue, Zirui; Chen, Shangwu; Li, Yingqiu; Dong, Meiling; Xu, Anlong; Huang, Shengfeng
Source:
Developmental and comparative immunology 2020 v.104 pp. 103554
ISSN:
0145-305X
Subject:
transcription factor NF-kappa B,   etc   ; Chordata; enzyme activity; fish; genes; humans; jaws; models; mutants; sumoylation; ubiquitin-protein ligase;     Show all 11 Subjects
Abstract:
... In mammals, PIAS proteins are important SUMO E3 ligases and act as versatile regulators of over sixty different proteins, including components from the NF-κB pathways. But the PIAS functions are not well-understood due to complicated molecular mechanisms and multiple gene paralogs with overlapping roles, which is especially true in lower vertebrates where dedicated studies are scarce. As a basal c ...
DOI:
10.1016/j.dci.2019.103554

11. (1 → 3)‐β‐d‐glucan enhances the toxicity induced by Bortezomib in rat testis

Author:
Akaras, Nurhan; Abuc, Ozlem Ozgul; Koc, Kubra; Bal, Tugba; Geyikoglu, Fatime; Atilay, Hilal; Erol, Huseyin Serkan; Yigit, Serdar; Gul, Murat
Source:
Journal of food biochemistry 2020 v.44 no.3 pp. e13155
ISSN:
0145-8884
Subject:
transcription factor NF-kappa B,   etc   ; antioxidant activity; antioxidant enzymes; catalase; cytotoxicity; fluorescent dyes; histopathology; immunohistochemistry; staining; superoxide dismutase; testes;     Show all 11 Subjects
Abstract:
... We aimed to determine the possible effects of the antioxidant agent (1 → 3)‐β‐D‐glucan on bortezomib‐induced rat testis damage. We used five groups of rats; control, (1 → 3)‐β‐D‐glucan (75 mg/kg), bortezomib group, bortezomib + (1 → 3)‐β‐D‐glucan groups (injection of (1 → 3)‐β‐D‐glucan after bortezomib and sacrificed at 48th or 72nd h). The effects of these substances were assessed by measuring th ...
DOI:
10.1111/jfbc.13155

12. Neuroinflammation in CNS diseases: Molecular mechanisms and the therapeutic potential of plant derived bioactive molecules

Author:
Welcome, Menizibeya O.
Source:
PharmaNutrition 2020 v.11 pp. 100176
ISSN:
2213-4344
Subject:
transcription factor NF-kappa B,   etc   ; bioactive compounds; complications (disease); diabetes; inflammation; neurodegenerative diseases; pathophysiology; phytochemicals; sclerosis; sleep disorders; stroke; therapeutics;     Show all 12 Subjects
Abstract:
... Over the past decades, evidences have consistently shown that Neuroinflammation is a critical underlying process in a range of CNS diseases, including neurodegenerative disorders, depression, sleep disorders, and stroke. Thus prevention of Neuroinflammation represents one of the most important goals in the treatment of these disorders. Unfortunately, the mechanisms of Neuroinflammation in differen ...
DOI:
10.1016/j.phanu.2020.100176

13. Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation

Author:
Williams, Leah M.; Inge, Melissa M.; Mansfield, Katelyn M.; Rasmussen, Anna; Afghani, Jamie; Agrba, Mikhail; Albert, Colleen; Andersson, Cecilia; Babaei, Milad; Babaei, Mohammad; Bagdasaryants, Abigail; Bonilla, Arianna; Browne, Amanda; Carpenter, Sheldon; Chen, Tiffany; Christie, Blake; Cyr, Andrew; Dam, Katie; Dulock, Nicholas; Erdene, Galbadrakh; Esau, Lindsie; Esonwune, Stephanie; Hanchate, Anvita; Huang, Xinli; Jennings, Timothy; Kasabwala, Aarti; Kehoe, Leanne; Kobayashi, Ryan; Lee, Migi; LeVan, Andre; Liu, Yuekun; Murphy, Emily; Nambiar, Avanti; Olive, Meagan; Patel, Devansh; Pavesi, Flaminio; Petty, Christopher A.; Samofalova, Yelena; Sanchez, Selma; Stejskal, Camilla; Tang, Yinian; Yapo, Alia; Cleary, John P.; Yunes, Sarah A.; Siggers, Trevor; Gilmore, Thomas D.
Source:
Developmental and comparative immunology 2020 v.104 pp. 103559
ISSN:
0145-305X
Subject:
transcription factor NF-kappa B,   etc   ; Amphimedon queenslandica; DNA; DNA-binding domains; binding sites; humans; phosphotransferases (kinases); transcriptional activation; transcriptome;     Show all 9 Subjects
Abstract:
... Herein, we characterize transcription factor NF-κB from the demosponge Amphimedon queenslandica (Aq). Aq–NF–κB is most similar to NF-κB p100/p105 among vertebrate proteins, with an N-terminal DNA-binding domain, a C-terminal Ankyrin (ANK) repeat domain, and a DNA binding-site profile akin to human NF-κB proteins. Like mammalian NF-κB p100, C-terminal truncation allows nuclear translocation of Aq–N ...
DOI:
10.1016/j.dci.2019.103559

14. Dual-Wavelength Electrochemiluminescence Ratiometric Biosensor for NF-κB p50 Detection with Dimethylthiodiaminoterephthalate Fluorophore and Self-Assembled DNA Tetrahedron Nanostructures Probe

Author:
Fan, Zhenqiang; Lin, Zongqiong; Wang, Zepeng; Wang, Jianfeng; Xie, Minhao; Zhao, Jianfeng; Zhang, Kai; Huang, Wei
Source:
ACS applied materials & interfaces 2020 v.12 no.10 pp. 11409-11418
ISSN:
1944-8252
Subject:
transcription factor NF-kappa B,   etc   ; DNA; DNA probes; biosensors; carbon nitride; detection limit; electrochemiluminescence; energy transfer; fluorescent dyes; gold; nanogold;     Show all 11 Subjects
Abstract:
... In this work, we fabricated a dual-wavelength electrochemiluminescence ratiometric biosensor based on electrochemiluminescent resonance energy transfer (ECL-RET). In this biosensor, Au nanoparticle-loaded graphitic phase carbon nitride (Au-g-C₃N₄) as a donor and Au-modified dimethylthiodiaminoterephthalate (TAT) analogue (Au@TAT) as an acceptor were investigated for the first time. Besides, tetrah ...
DOI:
10.1021/acsami.0c01243

15. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats

Author:
Topdağı, Ömer; Tanyeli, Ayhan; Akdemir, Fazile Nur Ekinci; Eraslan, Ersen; Güler, Mustafa Can; Çomaklı, Selim
Source:
Life sciences 2020 v.242 pp. 117217
ISSN:
0024-3205
Subject:
transcription factor NF-kappa B,   etc   ; acute kidney injury; antioxidant activity; ischemia; kidneys; males; oxidants; oxidative stress; protective effect; tissues;     Show all 10 Subjects
Abstract:
... Kidney ischemia reperfusion (IR) injury is an important health problem resulting in acute kidney failure. The oxidative stress and inflammatory process are the underlying mechanisms of IR injury. It has been purposed in this study to research the possible protective effects of fraxin on kidney injury induced by IR.32 Sprague Dawley male rats were divided into 4 groups. The groups were organized as ...
DOI:
10.1016/j.lfs.2019.117217

16. Inducible expression of defensins and cathelicidins by nutrients and associated regulatory mechanisms

Author:
Chen, Jialuo; Zhai, Zhenya; Long, Hongrong; Yang, Guangming; Deng, Baichuan; Deng, Jinping
Source:
Peptides 2020 v.123 pp. 170177
ISSN:
0196-9781
Subject:
transcription factor NF-kappa B,   etc   ; antibiotics; cathelicidins; histone deacetylase; immune response; mammals; mitogen-activated protein kinase; nutrients; signal transduction;     Show all 9 Subjects
Abstract:
... Host defense peptides (HDPs) are crucial components of the body's first line of defense that protect organisms from infections and mediate immune responses. Defensins and cathelicidins are the two most important families of HDPs in mammals. In this review, we summarize the nutrients that are involved in inducible expression of endogenous defensins and cathelicidins. In addition, the mitogen-activa ...
DOI:
10.1016/j.peptides.2019.170177

17. Porcine sialoadhesin suppresses type I interferon production to support porcine reproductive and respiratory syndrome virus infection

Author:
Liu, Yingqi; Li, Rui; Qiao, Songlin; Chen, Xin-xin; Deng, Ruiguang; Zhang, Gaiping
Source:
Veterinary research 2020 v.51 no.1 pp. 18
ISSN:
1297-9716
Subject:
transcription factor NF-kappa B,   etc   ; Porcine reproductive and respiratory syndrome virus; interferons; pathogenesis; porcine reproductive and respiratory syndrome; pork industry; swine;     Show all 7 Subjects
Abstract:
... Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant threat to the global swine industry. Porcine sialoadhesin (poSn) has been previously shown to mediate PRRSV attachment and internalization. In the current study, we report its unidentified role in antagonism of type I interferon (IFN) production during PRRSV infection. We determined that poSn facilitated PRRSV infection v ...
DOI:
10.1186/s13567-020-00743-7
PubMed:
32093750
PubMed Central:
PMC7038599

18. PDLIM2 acts as a cancer suppressor gene in non-small cell lung cancer via the down regulation of NF-κB signaling

Author:
Shi, Hongyang; Ji, Yuqiang; Li, Wei; Zhong, Yujie; Ming, Zongjuan
Source:
Molecular and cellular probes 2020 v.53 pp. 101628
ISSN:
0890-8508
Subject:
transcription factor NF-kappa B,   etc   ; antineoplastic activity; cell lines; demethylation; gene expression regulation; gene overexpression; lung neoplasms; therapeutics; tissues; tumor suppressor genes;     Show all 10 Subjects
Abstract:
... PDZ and LIM domain containing protein 2 (PDLIM2) has been identified as a vital tumor-associated gene that is aberrantly expressed in various types of tumors. Yet, the involvement of PDLIM2 in non-small cell lung cancer (NSCLC) is currently undetermined. The design of the current study was to evaluate whether PDLIM2 plays a role in NSCLC. We found that PDLIM2 expression was commonly decreased in N ...
DOI:
10.1016/j.mcp.2020.101628

19. Poria cocos water extract ameliorates the behavioral deficits induced by unpredictable chronic mild stress in rats by down-regulating inflammation

Author:
Huang, Yun-Ju; Hsu, Nai-Yuan; Lu, Kuan-Hung; Lin, Yu-En; Lin, Shih-Hang; Lu, Yun-Sheng; Liu, Wei-Ting; Chen, Mei-Hsing; Sheen, Lee-Yan
Source:
Journal of ethnopharmacology 2020 v.258 pp. 112566
ISSN:
0378-8741
Subject:
transcription factor NF-kappa B,   etc   ; Wolfiporia cocos; body weight; dopamine; forced swimming test; frontal lobe; inflammation; medicinal fungi; metabolites; rats; serotonin; sucrose; traditional medicine;     Show all 13 Subjects
Abstract:
... Poria cocos is a medicinal mushroom of the Polyporaceae family with antioxidant and anti-inflammatory activities, which has been used for its sedative, diuretic and tonic effects in traditional medicine for several hundred years.Considering that depression is an inflammatory related mental disease, this study investigated the antidepressant-like effects of water extract of P. cocos in a rodent ani ...
DOI:
10.1016/j.jep.2020.112566

20. Silencing KPNA2 inhibits IL-6-induced breast cancer exacerbation by blocking NF-κB signaling and c-Myc nuclear translocation in vitro

Author:
Duan, Mingyue; Hu, Fei; Li, Dan; Wu, Shouzhen; Peng, Niancai
Source:
Life sciences 2020 v.253 pp. 117736
ISSN:
0024-3205
Subject:
transcription factor NF-kappa B,   etc   ; breast neoplasms; carcinogenesis; inflammation; interleukin-17; interleukin-6; interleukin-8; karyopherins; loss-of-function mutation; models; nucleocytoplasmic transport; secretion; therapeutics;     Show all 13 Subjects
Abstract:
... Recently, studies indicated that inflammation could exacerbate the development of BC. Karyopherin α-2 (KPNA2) is a molecule which modulates nucleocytoplasmic transport and is involved in malignant cellular behavior and carcinogenesis. Our study aims to elucidate the role of KPNA2 in BC pathogenesis and explore the mechanism of KPNA2 in regulating inflammation-induced BC exacerbations.We measured t ...
DOI:
10.1016/j.lfs.2020.117736