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transcriptionfactorNF-kappaB, etc ; breast neoplasms; cell proliferation; death; humans; molecular biology; neoplasm cells; Show all 7 Subjects
Abstract:
... BACKGROUND: Breast cancer (BC) is the most common malignancy in females and is the second leading cause of cancer-related death among women worldwide. Midkine (MDK) is a heparin-binding growth factor that is abnormally expressed at high levels in various human malignancies. We aimed to uncover the biological function and molecular mechanism of MDK in BC cells. METHODS AND RESULTS: MDA-MB-231-shMDK ...
transcriptionfactorNF-kappaB, etc ; biomarkers; inflammation; lipopolysaccharides; macrophages; mice; protective effect; psoriasis; research; therapeutics; Show all 10 Subjects
Abstract:
... Psoriasiform skin inflammation is the common chronic skin inflammatory disease with no effective clinical therapy. Salubrinal is a multifunctional molecule playing a protective role in several conditions. Recently, studies have reported that Salubrinal is a potential therapeutic agent for inflammatory diseases. However, the protective role of Salubrinal in psoriasis-like skin inflammation remains ...
transcriptionfactorNF-kappaB, etc ; albino; apigenin; apoptosis; caspase-3; histology; intestines; irradiation; radioprotective effect; research; Show all 10 Subjects
Abstract:
... The objective of this study was to evaluate the protective effect of apigenin against radiation-induced gastrointestinal (GI) damages in whole-body irradiated (WBI) Swiss albino mice. Swiss albino mice were pre-treated with apigenin (15 mg/kg body wt.) intraperitoneally for six consecutive days, and on the seventh day, the mice were exposed to 7 Gy WBI. Histological findings revealed a deteriorati ...
transcriptionfactorNF-kappaB, etc ; apoptosis; biophysics; chondrocytes; humans; inflammation; interleukin-18; interleukin-8; metalloproteinases; models; proteolysis; Show all 11 Subjects
Abstract:
... The present study aimed to investigate the expression of miR9 and its correlation with cytokines, proteolytic enzymes and apoptosis in an experimental model of 6-mer HA induced inflammation in human chondrocytes. Human articular chondrocytes, transfected with a miR-9 mimic and miR-9 inhibitor, were stimulated with 6-mer HA in presence/absence of a specific NF-kB inhibitor. 6-mer HA induced a signi ...
transcriptionfactorNF-kappaB, etc ; Toll-like receptors; bioavailability; dietary supplements; flavonoids; food research; metabolism; nanocarriers; prostaglandin synthase; Show all 9 Subjects
Abstract:
... Flavonoids possess an impressive therapeutic potential, thereby imparting them a nutraceutical character. As it becomes increasingly common to consume foods associated with healing properties, it is imperative to understand the associations of different foods with different classes of nutraceutic compounds, and their mechanisms of therapeutic action. At the same time, it is important to address th ...
transcriptionfactorNF-kappaB, etc ; diabetic retinopathy; glucose; inflammation; interleukin-1beta; mice; research; retina; therapeutics; tumor necrosis factor-alpha; Show all 10 Subjects
Abstract:
... The inflammatory changes seem to play an important role in the development of diabetic retinopathy (DR). Anti-VEGF therapy has been testified to inhibit inflammation in animal models of diabetes, but the detailed mechanisms during this process are not yet clear. Müller glial cells (MGCs) in the mammalian retina are deeply involved in DR, while the BDNF overexpression reduces inflammation in diabet ...
transcriptionfactorNF-kappaB, etc ; Kadsura coccinea; arthritis; cytotoxicity; ethanol; inflammation; interleukin-6; plant biochemistry; sesquiterpenoids; spectral analysis; traditional medicine; Show all 11 Subjects
Abstract:
... The roots of Kadsura coccinea is commonly used in Tujia ethnomedicine, named “heilaohu”, having the effect of treating rheumatic arthritis (RA). Chemical investigation on the ethanol extract of heilaohu led to the isolation of one undescribed cuparane sesquiterpenoid, heilaohusesquiterpenoid A, one undescribed carotane sesquiterpenoids, heilaohusesquiterpenoid B, and eighteen sesquiterpene derivat ...
transcriptionfactorNF-kappaB, etc ; databases; discriminant analysis; gastric mucosa; indigestion; liquid chromatography; mitogen-activated protein kinase; pharmacology; temperature; traditional medicine; Show all 10 Subjects
Abstract:
... Processing, also called Paozhi in Chinese, is an ancient Chinese pharmaceutic processing technique developed along with the Chinese herbal medicines (CHMs). The understanding of the mechanism of Paozhi has been investigated for several decades. Aucklandiae Radix (CAR) and its roasted processed products are all used in indigestion as a kind of CHMs. Processed Aucklandiae Radix (PAR) had a stronger ...
... Eugenol (4-allyl -2- methoxyphenol), reportedly, a native compound that widely exists in a variety of plants, shows diverse biological activities such as anti-bacteria, anti-inflammation and anti-oxidation. This work was to delve into the effects and molecular mechanisms of eugenol on the phenotypes of fibroblast-like synovial cells from rheumatoid arthritis (RA). Fibroblast-like synovial cells tr ...
... Inflammation is the underlying factor for degenerative diseases; hence, targeting inflammatory cascades are of greater importance in preventing these disorders. The traditionally used medical plant Thottea siliquosa is often used against inflammation associated health problems in folk medicines. To provide scientific validation to their traditional uses, the potential of the methanol extract of th ...
... Nuclear factor-kappa B (NF-κB) signaling is an intracellular signaling pathway involved in inflammatory responses and the pathogenesis of various cancers, including ependymoma, which is a rare and chemotherapy-resistant glioma. Several isoforms of fusion proteins that consist of a nuclear protein, zinc finger translocation associated (ZFTA), and RELA (ZFTA-RELA), an NF-κB-signaling effector transc ...
transcriptionfactorNF-kappaB, etc ; astrocytes; atherosclerosis; blood serum; caspase-1; cognitive disorders; diet; inflammasomes; lipopolysaccharides; mice; occludins; phosphorylation; phytotherapy; protein synthesis; research; Show all 15 Subjects
Abstract:
... Crocin has been extensively investigated in treating neurodegenerative diseases. However, its effect on cognitive impairment associated with atherosclerosis remains unknown. The present study aimed to explore the potential mechanism of crocin on cognitive impairment in a mouse model of atherosclerosis. LDLR⁻/⁻ mice fed a high‐fat/cholesterol diet were administered variable‐dose crocin for 56 days ...
... Ganoderma lucidum (G. lucidum) main attractive pharmacological characteristics are antitumor and immunomodulatory activities which are chiefly associated with its two principal bioactive compounds, those are polysaccharides and triterpenoids. Ganoderic acids (GAs) are one of the most discovered triterpenoids of G. lucidum among various triterpenoids. The prominent medicinal mushroom G. lucidum pos ...
... Ginsenoside compound K (CK) has been shown to exhibit anti-inflammatory properties. In this study, to encourage biomedical applications of biosynthesized gold nanoparticles (AuNPs) with anti-inflammatory effects, AuNPs loaded with ginsenoside compound K were prepared using a self-assembly technique with chitosan as the carrier. Optimal conditions for chitosan-ginsenoside CK‑gold nanoparticles (CS- ...
transcriptionfactorNF-kappaB, etc ; Ziziphus; catechin; cytoplasm; inflammation; interleukin-6; lipopolysaccharides; mitogen-activated protein kinase; oxidative stress; p-coumaric acid; polyphenols; rutin; synergism; toxicology; Show all 14 Subjects
Abstract:
... Jujube has great potential as food and traditional drugs in several countries. To study the anti-inflammatory influence of jujube peel polyphenols in lipopolysaccharide (LPS) induced RAW 264.7 cells through mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB) and nuclear erythroid 2-related factor 2 (Nrf2) signaling pathways. In this study, the phenolic composition of polyphenol ...
transcriptionfactorNF-kappaB, etc ; ammonium; animal reproduction; apoptosis; blastocyst; embryogenesis; energy; gene expression; genes; interleukin-6; linoleic acid; polyunsaturated fatty acids; protein synthesis; swine; Show all 14 Subjects
Abstract:
... Fatty acid has a various role in preimplantation embryo development. Especially, Linoleic acid, polyunsaturated fatty acid, has been reported to affect the apoptosis pathway via nuclear transcription factor-kappa B. But to date, the function of NF-κB has not been demonstrated in porcine preimplantation embryos. We demonstrated that linoleic acid had a positive effect on embryo development at a cer ...
transcriptionfactorNF-kappaB, etc ; AMP-activated protein kinase; Eleutherococcus gracilistylus; Toll-like receptor 4; bark; cardioprotective effect; diterpenoids; gastrointestinal system; interleukin-1; liver; plant biochemistry; Show all 11 Subjects
Abstract:
... Acanthoic acid (AA) is a pimaradiene diterpene isolated from the root bark of Acanthopanax koreanum Nakai (Araliaceae) with a wide range of pharmacological activities, including anti-cancer, anti-inflammatory, anti-diabetes, liver protection, gastrointestinal protection, and cardiovascular protection. In addition, AA promotes its pharmacological effects by targeting liver X receptors (LXRs), nucle ...
... 4-octylphenol (4-OP), a toxic estrogenic environmental pollutant, can threaten aquatic animal and human health. However, toxic effect of 4-OP on fish has not been reported. To investigate molecular mechanism of gill poisoning caused by 4-OP exposure, a carp 4-OP poisoning model was established, and then blood and gills were collected on day 60. The results demonstrated that gill was a target organ ...
transcriptionfactorNF-kappaB, etc ; Panax; endometriosis; gene expression; immunohistochemistry; inflammation; mice; mitogen-activated protein kinase; phthalates; plasticizers; prostaglandin synthase; research; sequence analysis; therapeutics; uterine neoplasms; Show all 15 Subjects
Abstract:
... Di-(2-ethylhexyl) phthalate (DEHP) is the most common endocrine disrupting chemical used as a plasticizer. DEHP is associated with the development of endometrium-related diseases through the induction of inflammation. The major therapeutic approaches against endometrial cancer and endometriosis involve the suppression of inflammatory response. Korean Red Ginseng (KRG) is a natural product with ant ...
transcriptionfactorNF-kappaB, etc ; animals; carbon dioxide; continental climates; cytotoxicity; dietary supplements; green chemistry; humidity; phytochemicals; soil; solar radiation; urban areas; urban horticulture; value added; Show all 14 Subjects
Abstract:
... Urban horticulture and vertical gardens provide many benefits for the population in urban areas. A rational selection of plants in these features can introduce a potential for value-added products including extracts of nutraceuticals. Helichrysum. italicum was grown in the urban environment, on a vertical surface in the form of a green wall. Since the location was in a town with continental climat ...