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1. Polyphenol-bradykinin interaction: Role in pain sensation

Author:
Adrar, Nassim Salem; Madani, Khodir; Adrar, Sabah
Source:
Food bioscience 2021 v.41 pp. 100935
ISSN:
2212-4292
Subject:
transcription factor NF-kappa B,   etc   ; bioavailability; bradykinin; encapsulation; nitric oxide; pain; phospholipases; polyphenols;     Show all 8 Subjects
Abstract:
... It can be deduced from this concise review that bradykinin and polyphenols could have a double role in health. Nevertheless, if their bioavailability is improved by their encapsulation, polyphenols could diminish the binding affinity of bradykinin to its receptors by causing a conformational rearrangement of the peptide. Besides, the interaction between polyphenols and bradykinin should play a rol ...
DOI:
10.1016/j.fbio.2021.100935

2. Alternate immersion in glucose to produce prolonged hyperglycemia in zebrafish

Author:
McCarthy, Elizabeth; Rowe, Cassie J.; Crowley-Perry, Mikayla; Connaughton, Victoria P.
Source:
Journal of visualized experiments 2021 no.171 pp. e61935
ISSN:
1940-087X
Subject:
transcription factor NF-kappa B,   etc   ; Danio rerio; adults; blood glucose; cognition; glucose; hyperglycemia; models; retina;     Show all 9 Subjects
Abstract:
... Zebrafish (Danio rerio) are an excellent model to investigate the effects of chronic hyperglycemia, a hallmark of Type II Diabetes Mellitus (T2DM). This alternate immersion protocol is a noninvasive, step-wise method of inducing hyperglycemia for up to eight weeks. Adult zebrafish are alternately exposed to sugar (glucose) and water for 24 hours each. The zebrafish begin treatment in a 1% glucose ...
DOI:
10.3791/61935

3. Research Note: Anti-inflammatory effects and antiviral activities of baicalein and chlorogenic acid against infectious bursal disease virus in embryonic eggs

Author:
Li, Yinju; Yang, Danfang; Jia, Yanyan; He, Lei; Li, Jing; Yu, Chuan; Liao, Chengshui; Yu, Zuhua; Zhang, Chunjie
Source:
Poultry science 2021 v.100 no.4 pp. 100987
ISSN:
0032-5791
Subject:
transcription factor NF-kappa B,   etc   ; Infectious bursal disease virus; chickens; chlorogenic acid; histamine;     Show all 5 Subjects
Abstract:
... The purpose of this study was to investigate if baicalein and chlorogenic acid could inhibit the inflammatory responses induced by and protect against infectious bursal disease virus (IBDV) in chicken embryonic eggs. Nine-day-old embryonated chicken eggs were randomly divided into 3 groups of 50 eggs per group: 1) treatment with varying concentrations of baicalein, 2) treatment with varying concen ...
DOI:
10.1016/j.psj.2021.01.010

4. Arid2-IR promotes NF-κB-mediated renal inflammation by targeting NLRC5 transcription

Author:
Zhang, Puhua; Yu, Chaolun; Yu, Jianwen; Li, Zhijian; Lan, Hui-yao; Zhou, Qin
Source:
Cellular and molecular life sciences 2021 v.78 no.5 pp. 2387-2404
ISSN:
1420-682X
Subject:
transcription factor NF-kappa B,   etc   ; cytoplasm; filamin; inflammation; kidneys; luciferase; therapeutics;     Show all 7 Subjects
Abstract:
... Increasing evidence shows that long non-coding RNAs (lncRNAs) play an important role in a variety of disorders including kidney diseases. It is well recognized that inflammation is the initial step of kidney injury and is largely mediated by nuclear factor Kappa B (NF-κB) signaling. We had previously identified lncRNA-Arid2-IR is an inflammatory lncRNA associated with NF-κB-mediated renal injury. ...
DOI:
10.1007/s00018-020-03659-9

5. The Role of the Curcumin for Inducing Apoptosis in Acute Lymphoblastic Leukemia Cells: A Systematic Review

Author:
Haghighian, Hossein Khadem; Ketabchi, Neda; Kavianpour, Maria
Source:
Nutrition and cancer 2021 v.73 no.7 pp. 1081-1091
ISSN:
1532-7914
Subject:
transcription factor NF-kappa B,   etc   ; antineoplastic activity; apoptosis; asparaginase; curcumin; drug therapy; lymphocytic leukemia; nutrition; systematic review;     Show all 9 Subjects
Abstract:
... Acute lymphoblastic leukemia (ALL) is a hematological malignancy of lymphoid progenitor cells associated with excessive proliferation of lymphocytes. Curcumin, a polyphenolic compound, is known to possess anticancer activity. However, the mechanism of apoptosis induction differs in cancers. In this study, we discuss the potential apoptosis and anticancer effect of curcumin on the ALL. After choosi ...
DOI:
10.1080/01635581.2020.1791916

6. Anti-aging effects of peppermint (Mentha piperita L.) and Shirazi thyme (Zataria multiflora Boiss.) plant extracts

Author:
Sarikhani, Manizheh; Deylam, Mahla; Alizadeh, Effat; Hejazy, Marzie; Alizadeh-Salteh, Saeideh; Moeini, Hassan; Firouzamandi, Masoumeh
Source:
Food bioscience 2021 v.41 pp. 100930
ISSN:
2212-4292
Subject:
transcription factor NF-kappa B,   etc   ; Mentha piperita nothosubsp. piperita; Zataria multiflora; adipose tissue; beta-galactosidase; bone marrow; genes; rats; thyme;     Show all 9 Subjects
Abstract:
... Peppermint (Mentha piperita L.) Shirazi thyme (Zataria multiflora Boiss.) have been reported to exhibit several biological beneficial activities. However, the biological activities related to anti-ageing have not been reported so far. In this study, we evaluated anti-aging properties of the peppermint and Shirazi thyme extracts in rat mesenchymal stem cells (MSCs) isolated from bone marrow and adi ...
DOI:
10.1016/j.fbio.2021.100930

7. Modulation of cathelicidin and defensins by histone deacetylase inhibitors: A potential treatment for multi-drug resistant infectious diseases

Author:
Rodríguez-Carlos, Adrián; Jacobo-Delgado, Yolanda M.; Santos-Mena, Alan O.; Rivas-Santiago, Bruno
Source:
Peptides 2021 v.140 pp. 170527
ISSN:
0196-9781
Subject:
transcription factor NF-kappa B,   etc   ; ; cathelicidins; chromatin; histone deacetylase; immune response; immune system; multiple drug resistance; public health;     Show all 9 Subjects
Abstract:
... Infectious diseases are an important growing public health problem, which perspective has worsened due to the increasing number of drug-resistant strains in the last few years. Although diverse solutions have been proposed, one viable solution could be the use of immune system modulators. The induction of the immune response can be increased by histone deacetylase inhibitors (iHDAC), which in turn ...
DOI:
10.1016/j.peptides.2021.170527

8. miR-217 through SIRT1 regulates the immunotoxicity of cadmium in Cyprinus carpio

Author:
Li, Hui; Di, Guilan; Zhang, Yi; Liang, Junping; Wang, Xianfeng; Xu, Zhenshan; Kong, Xianghui
Source:
Comparative biochemistry and physiology 2021 pp. 109086
ISSN:
1532-0456
Subject:
transcription factor NF-kappa B,   etc   ; Cyprinus carpio; cadmium; eosin; fish; heavy metals; immunotoxicity; interleukin-8; microRNA; physiology;     Show all 10 Subjects
Abstract:
... MicroRNAs (miRNAs) play a critical role in regulating the response of animals exposed to heavy metal stress. As a globally dispersed heavy metal in aquatic ecosystems, cadmium (Cd) is highly toxic to many aquatic species. However, little is known about the miRNA response to Cd stress in fish. To investigate the regulatory effect of miRNAs in response to Cd, common carp (Cyprinus carpio) were expos ...
DOI:
10.1016/j.cbpc.2021.109086

9. Lithium alleviated spinal cord injury (SCI)-induced apoptosis and inflammation in rats via BDNF-AS/miR-9-5p axis

Author:
Wang, Fang; Chang, Sue; Li, Jie; Wang, Dong; Li, Haopeng; He, Xijing
Source:
Cell and tissue research 2021 v.384 no.2 pp. 301-312
ISSN:
0302-766X
Subject:
transcription factor NF-kappa B,   etc   ; animal injuries; animal models; apoptosis; death; histology; inflammation; lithium; lithium chloride; paralysis; research; spinal cord;     Show all 12 Subjects
Abstract:
... Spinal cord injury (SCI) is a major cause of paralysis, disability and even death in severe cases. Lithium has neuroprotective effects on SCI, while the underlying mechanisms remain obscure. In the present study, we established a SCI rat model, which subsequently received lithium treatment. Results displayed that lithium treatment improved the locomotor function recovery and reduced apoptosis by i ...
DOI:
10.1007/s00441-020-03298-3

10. Wutou decoction ameliorates experimental rheumatoid arthritis via regulating NF-kB and Nrf2: Integrating efficacy-oriented compatibility of traditional Chinese medicine

Author:
Xie, Ying; Mai, Chu-Tian; Zheng, De-Chong; He, Yu-Fei; Feng, Sen-Lin; Li, Ya-Zhou; Liu, Chang-Xiao; Zhou, Hua; Liu, Liang
Source:
Phytomedicine 2021 v.85 pp. 153522
ISSN:
0944-7113
Subject:
transcription factor NF-kappa B,   etc   ; Oriental traditional medicine; animal models; inflammation; macrophages; pharmacology; phosphorylation; rheumatoid arthritis; therapeutics;     Show all 9 Subjects
Abstract:
... Thousands of years of clinical application of Wutou decoction (WTD) support its reliable efficacy and safety in treating rheumatoid arthritis (RA). However, the underlying molecular mechanism remains unclear, and the synergistic involvement of assistant herbs in WTD in enhancing the sovereign herb in treating RA is unknown.This study aimed to investigate the efficacy-oriented compatibility of five ...
DOI:
10.1016/j.phymed.2021.153522

11. Phytochemicals against anti‐diabetic complications: targeting the advanced glycation end product signaling pathway

Author:
Parveen, Amna; Sultana, Razia; Lee, Seung Min; Kim, Tae Hun; Kim, Sun Yeou
Source:
Archives of pharmacal research 2021 v.44 no.4 pp. 378-401
ISSN:
0253-6269
Subject:
transcription factor NF-kappa B,   etc   ; advanced glycation end products; diabetes; necrosis; neoplasms; phytochemicals; reactive oxygen species; research; therapeutics;     Show all 9 Subjects
Abstract:
... The role of advanced glycation end products (AGEs) is not limited to diabetes and diabetes-related complications. There are multiple modulators, including the receptor for advanced glycation end products, high mobility group box 1, glyoxalase 1, nuclear factor-kappa B, tumor necrosis factor-α, chronic unpredictable stress, reactive oxygen species, and inflammatory cytokines, which interact with AG ...
DOI:
10.1007/s12272-021-01323-9

12. Effects of NF-kB Signaling Inhibitors on Bed Bug Resistance to Orally Provisioned Entomopathogenic Bacteria

Author:
Pietri, Jose E.; Potts, Rashaun
Source:
Insects 2021 v.12 no.4
ISSN:
2075-4450
Subject:
transcription factor NF-kappa B,   etc   ; ; Bacillus thuringiensis subsp. israelensis; Cimicidae; Pseudomonas; biological control; blood meal; immune system; mortality; toxicity;     Show all 10 Subjects
Abstract:
... Bed bugs are globally important pests and there is an ongoing need for the development and improvement of bed bug control tools. Though promising against other insect pests, the exploration of biological methods for bed bug control is limited. Previously, we identified several species of bacteria that have entomopathogenic effects against bed bugs when ingested. We also described the conservation ...
DOI:
10.3390/insects12040303

13. CircRNA_0050463 promotes influenza A virus replication by sponging miR-33b-5p to regulate EEF1A1

Author:
Shi, Ning; Zhang, Shu; Guo, Yidi; Yu, Xiuhua; Zhao, Weizheng; Zhang, Maolin; Guan, Zhenhong; Duan, Ming
Source:
Veterinary microbiology 2021 v.254 pp. 108995
ISSN:
0378-1135
Subject:
transcription factor NF-kappa B,   etc   ; Influenza A virus; chemical bonding; cytoplasm; luciferase; peptide elongation factors; virus replication;     Show all 7 Subjects
Abstract:
... Circular RNAs (circRNAs), a new class of widely expressed endogenous regulatory RNAs, are characterized by a covalently closed loop structure without a 5' cap or 3' tail. Increasing numbers of studies have shown that circRNAs play important roles in diverse physiological and pathological processes, including the dynamic interactions between viruses and hosts. However, their multifaceted roles in c ...
DOI:
10.1016/j.vetmic.2021.108995

14. Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies

Author:
D’Orazi, Gabriella; Cordani, Marco; Cirone, Mara
Source:
Cellular and molecular life sciences 2021 v.78 no.5 pp. 1853-1860
ISSN:
1420-682X
Subject:
transcription factor NF-kappa B,   etc   ; DNA; autophagy; cancer therapy; carcinogenesis; immune response; inflammation; interleukin-6; mutants; neoplasm progression; neoplasms;     Show all 11 Subjects
Abstract:
... Inflammation and cancerogenesis are strongly interconnected processes, not only because inflammation promotes DNA instability, but also because both processes are driven by pathways such as NF-kB, STAT3, mTOR and MAPKs. Interestingly, these pathways regulate the release of pro-inflammatory cytokines such as IL-6, TNF-α and IL-1β that in turn control their activation and play a crucial role in shap ...
DOI:
10.1007/s00018-020-03677-7

15. Quercetin Oxidation Metabolite Present in Onion Peel Protects Caco-2 Cells against the Oxidative Stress, NF-kB Activation, and Loss of Epithelial Barrier Function Induced by NSAIDs

Author:
Fuentes, Jocelyn; de Camargo, Adriano Costa; Atala, Elías; Gotteland, Martín; Olea-Azar, Claudio; Speisky, Hernán
Source:
Journal of agricultural and food chemistry 2021 v.69 no.7 pp. 2157-2167
ISSN:
1520-5118
Subject:
transcription factor NF-kappa B,   etc   ; diclofenac; epithelium; food chemistry; ibuprofen; indomethacin; intestines; metabolites; onion peels; oxidation; oxidative stress; permeability; quercetin;     Show all 13 Subjects
Abstract:
... The potential of 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (BZF), a quercetin oxidation metabolite, and that of a BZF-rich onion peel aqueous extract (OAE) to protect Caco-2 monolayers against the oxidative stress (OS) and an increased permeability (IP) induced by five nonsteroidal anti-inflammatory drugs (NSAIDs) (indomethacin, diclofenac, piroxicam, ibuprofen, and metamizole) ...
DOI:
10.1021/acs.jafc.0c07085

16. FGF9 induces neurite outgrowth upon ERK signaling in knock-in striatal Huntington's disease cells

Author:
Yusuf, Issa Olakunle; Chen, Hsiu-Mei; Cheng, Pei-Hsun; Chang, Chih-Yi; Tsai, Shaw-Jenq; Chuang, Jih-Ing; Wu, Chia-Ching; Huang, Bu-Miin; Sun, H. Sunny; Chen, Chuan-Mu; Yang, Shang-Hsun
Source:
Life sciences 2021 v.267 pp. 118952
ISSN:
0024-3205
Subject:
transcription factor NF-kappa B,   etc   ; cytoskeleton; fibroblast growth factors; fluorescent antibody technique; mitogen-activated protein kinase; neurites; neurodegenerative diseases; therapeutics;     Show all 8 Subjects
Abstract:
... Huntington's disease (HD) is a neurodegenerative disease that causes deficits in neurite outgrowth, which suggests that enhancement of neurite outgrowth is a potential direction by which to improve HD. Our previous publications showed that fibroblast growth factor 9 (FGF9) provides anti-apoptosis and anti-oxidative functions in striatal cell models of HD through the extracellular signal–regulated ...
DOI:
10.1016/j.lfs.2020.118952

17. The efficacy of berries against lipopolysaccharide-induced inflammation: A review

Author:
Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Cianciosi, Danila; Quiles, José L.; Mezzetti, Bruno; Xiao, Jianbo; Giampieri, Francesca; Battino, Maurizio
Source:
Trends in food science & technology 2021
ISSN:
0924-2244
Subject:
transcription factor NF-kappa B,   etc   ; antioxidant activity; blueberries; diet; endotoxins; food science; grapes; health promotion; inflammation; lipopolysaccharides; phytochemicals; technology;     Show all 12 Subjects
Abstract:
... an increasing number of epidemiological studies highlights a remarkable association between a diet rich in fruits and vegetables and a lower incidence of different inflammatory-related pathologies. Berries represent an interesting source of phytochemicals and nutrients, widely investigated for their role in health promotion and disease prevention.the aim of this review was to summarize and update ...
DOI:
10.1016/j.tifs.2021.01.015

18. miR146a up-regulation is involved in small HA oligosaccharides-induced pro-inflammatory response in human chondrocytes

Author:
Avenoso, Angela; D'Ascola, Angela; Scuruchi, Michele; Mandraffino, Giuseppe; Campo, Salvatore; Campo, Giuseppe M.
Source:
Biochimica et biophysica acta 2021 v.1865 no.1 pp. 129731
ISSN:
0304-4165
Subject:
transcription factor NF-kappa B,   etc   ; cartilage; cell proliferation; chondrocytes; gene expression; humans; inflammation; interleukin-6; microRNA; models; therapeutics; transfection;     Show all 12 Subjects
Abstract:
... Small HA fragments are produced during cartilage degradation and their role seems to be preponderant during pathologies in which cartilage injury contribute to trigger and perpetuate the inflammatory mechanism.Several reports have increasingly shown that MicroRNAs (miRs), a small non-coding mRNAs are involved in the regulation of multiple biological processes, including cell proliferation and infl ...
DOI:
10.1016/j.bbagen.2020.129731

19. Gastro protecting influence of Topiramate in ethanol produced gastric ulcers in rats

Author:
Kadasah, Saeed; Al Eid, Ahmad Saleh; Alawad, Salem Saleh; Al Shahrani, Abdullah S.; Alruwaihi, Ahmed Salem; Elfaki, Ibrahim; Arshaduddin, Mohammed
Source:
Toxicology reports 2021 v.8 pp. 1031-1039
ISSN:
2214-7500
Subject:
transcription factor NF-kappa B,   etc   ; ; acidity; anticonvulsants; apoptosis; ethanol; histology; inflammation; males; mucus; myeloperoxidase; secretion; stomach ulcers; toxicology;     Show all 14 Subjects
Abstract:
... Topiramate (TPM), an antiepileptic drug, is also effective against alcohol dependency, a crucial factor in forming gastric ulcers. There is an increased possibility of patients with compromised gastric conditions getting exposed to TPM, but its effect on gastric ulcers is unknown. This study investigates the implication of acute TPM in ethanol-produced gastric ulceration in rats.The effect of TPM ...
DOI:
10.1016/j.toxrep.2021.05.004

20. PS-341 alleviates chronic low-grade inflammation and improves insulin sensitivity through the inhibition of TM4 (UBAC2) degradation

Author:
Chen, Lili; Ye, Kuanping; Feng, Xiaocheng; Li, Lianxi; Li, Qin; Huang, Ying; Wang, Xuanchun; Li, Rumei; Hu, Cheng; Yang, Zhen; Lu, Bin; Yang, Yehong; Wen, Jie; Zhang, Zhaoyun; He, Min; Wang, Qinghua; Zhou, Wenbai; Li, Yintao; Liu, Naijia; Huang, Jinya; Shen, Qiwei; Yao, Qiyuan; Hu, Renming
Source:
Nutrition & metabolism 2021 v.18 no.1 pp. 54
ISSN:
1743-7075
Subject:
transcription factor NF-kappa B,   etc   ; Chinese people; glucose; high fat diet; hyperglycemia; hypertension; inflammation; insulin resistance; liver; metabolism; noninsulin-dependent diabetes mellitus; obesity; ubiquitin; visceral fat;     Show all 14 Subjects
Abstract:
... BACKGROUND: The TM4 (UBAC2) protein, which contains 4 transmembrane domains and one ubiquitin binding domain, is mainly expressed in cell and nuclear membranes. The current research aimed to explore the role of TM4 in metabolic inflammation and to examine whether the ubiquitin–proteasome inhibitor PS-341 could regulate the function of TM4. METHODS: The metabolic phenotypes of TM4 knockout (KO) mic ...
DOI:
10.1186/s12986-021-00579-8