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1. Midkine promotes breast cancer cell proliferation and migration by upregulating NR3C1 expression and activating the NF-κB pathway

Author:
Lin Zhang; Li Song; Yanyan Xu; Yuting Xu; Maojin Zheng; Peng Zhang; Qingling Wang
Source:
Molecular biology reports 2022 v.49 no.4 pp. 2953-2961
ISSN:
0301-4851
Subject:
transcription factor NF-kappa B,   etc   ; breast neoplasms; cell proliferation; death; humans; molecular biology; neoplasm cells;     Show all 7 Subjects
Abstract:
... BACKGROUND: Breast cancer (BC) is the most common malignancy in females and is the second leading cause of cancer-related death among women worldwide. Midkine (MDK) is a heparin-binding growth factor that is abnormally expressed at high levels in various human malignancies. We aimed to uncover the biological function and molecular mechanism of MDK in BC cells. METHODS AND RESULTS: MDA-MB-231-shMDK ...
DOI:
10.1007/s11033-022-07116-7

2. Salubrinal protects against inflammatory response in macrophage and attenuates psoriasiform skin inflammation by antagonizing NF-κB signaling pathway

Author:
Yangtao Shangguan; Yongkun Chen; Yihui Ma; Yunpeng Zhao; Yeteng He; Weiwei Li
Source:
Biochemical and biophysical research communications 2022 v.589 pp. 63-70
ISSN:
0006-291X
Subject:
transcription factor NF-kappa B,   etc   ; biomarkers; inflammation; lipopolysaccharides; macrophages; mice; protective effect; psoriasis; research; therapeutics;     Show all 10 Subjects
Abstract:
... Psoriasiform skin inflammation is the common chronic skin inflammatory disease with no effective clinical therapy. Salubrinal is a multifunctional molecule playing a protective role in several conditions. Recently, studies have reported that Salubrinal is a potential therapeutic agent for inflammatory diseases. However, the protective role of Salubrinal in psoriasis-like skin inflammation remains ...
DOI:
10.1016/j.bbrc.2021.11.066

3. Apigenin prevents gamma radiation-induced gastrointestinal damages by modulating inflammatory and apoptotic signalling mediators

Author:
Naziya Begum; N. Rajendra Prasad; G. Kanimozhi; B. Agilan
Source:
Natural product research 2022 v.36 no.6 pp. 1631-1635
ISSN:
1478-6427
Subject:
transcription factor NF-kappa B,   etc   ; albino; apigenin; apoptosis; caspase-3; histology; intestines; irradiation; radioprotective effect; research;     Show all 10 Subjects
Abstract:
... The objective of this study was to evaluate the protective effect of apigenin against radiation-induced gastrointestinal (GI) damages in whole-body irradiated (WBI) Swiss albino mice. Swiss albino mice were pre-treated with apigenin (15 mg/kg body wt.) intraperitoneally for six consecutive days, and on the seventh day, the mice were exposed to 7 Gy WBI. Histological findings revealed a deteriorati ...
DOI:
10.1080/14786419.2021.1893316

4. miR9 inhibits 6-mer HA-induced cytokine production and apoptosis in human chondrocytes by reducing NF-kB activation

Author:
Michele Scuruchi; Angela D'Ascola; Angela Avenoso; Annie Zappone; Giuseppe Mandraffino; Salvatore Campo; Giuseppe M. Campo
Source:
Archives of biochemistry and biophysics 2022 v.718 pp. 109139
ISSN:
0003-9861
Subject:
transcription factor NF-kappa B,   etc   ; apoptosis; biophysics; chondrocytes; humans; inflammation; interleukin-18; interleukin-8; metalloproteinases; models; proteolysis;     Show all 11 Subjects
Abstract:
... The present study aimed to investigate the expression of miR9 and its correlation with cytokines, proteolytic enzymes and apoptosis in an experimental model of 6-mer HA induced inflammation in human chondrocytes. Human articular chondrocytes, transfected with a miR-9 mimic and miR-9 inhibitor, were stimulated with 6-mer HA in presence/absence of a specific NF-kB inhibitor. 6-mer HA induced a signi ...
DOI:
10.1016/j.abb.2022.109139

5. Flavonoids: Food associations, therapeutic mechanisms, metabolism and nanoformulations

Author:
Niharika Kaushal; Minni Singh; Rajender Singh Sangwan
Source:
Food research international 2022 v.157 pp. 111442
ISSN:
0963-9969
Subject:
transcription factor NF-kappa B,   etc   ; Toll-like receptors; bioavailability; dietary supplements; flavonoids; food research; metabolism; nanocarriers; prostaglandin synthase;     Show all 9 Subjects
Abstract:
... Flavonoids possess an impressive therapeutic potential, thereby imparting them a nutraceutical character. As it becomes increasingly common to consume foods associated with healing properties, it is imperative to understand the associations of different foods with different classes of nutraceutic compounds, and their mechanisms of therapeutic action. At the same time, it is important to address th ...
DOI:
10.1016/j.foodres.2022.111442

6. Regulation of inflammation by VEGF/BDNF signaling in mouse retinal Müller glial cells exposed to high glucose

Author:
Minqi Zhu; Na Li; Yanuo Wang; Shuang Gao; Jing Wang; Xi Shen
Source:
Cell and tissue research 2022 v.388 no.3 pp. 521-533
ISSN:
0302-766X
Subject:
transcription factor NF-kappa B,   etc   ; diabetic retinopathy; glucose; inflammation; interleukin-1beta; mice; research; retina; therapeutics; tumor necrosis factor-alpha;     Show all 10 Subjects
Abstract:
... The inflammatory changes seem to play an important role in the development of diabetic retinopathy (DR). Anti-VEGF therapy has been testified to inhibit inflammation in animal models of diabetes, but the detailed mechanisms during this process are not yet clear. Müller glial cells (MGCs) in the mammalian retina are deeply involved in DR, while the BDNF overexpression reduces inflammation in diabet ...
DOI:
10.1007/s00441-022-03622-z

7. Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways

Author:
Yupei Yang; Yongbei Liu; Huanghe Yu; Qingling Xie; Bin Wang; Sai Jiang; Wei Su; Yu Mao; Bin Li; Caiyun Peng; Yuqing Jian; Wei Wang
Source:
Phytochemistry 2022 v.194 pp. 113018
ISSN:
0031-9422
Subject:
transcription factor NF-kappa B,   etc   ; Kadsura coccinea; arthritis; cytotoxicity; ethanol; inflammation; interleukin-6; plant biochemistry; sesquiterpenoids; spectral analysis; traditional medicine;     Show all 11 Subjects
Abstract:
... The roots of Kadsura coccinea is commonly used in Tujia ethnomedicine, named “heilaohu”, having the effect of treating rheumatic arthritis (RA). Chemical investigation on the ethanol extract of heilaohu led to the isolation of one undescribed cuparane sesquiterpenoid, heilaohusesquiterpenoid A, one undescribed carotane sesquiterpenoids, heilaohusesquiterpenoid B, and eighteen sesquiterpene derivat ...
DOI:
10.1016/j.phytochem.2021.113018

8. Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix

Author:
Shen Song; Rongli Qiu; Xiaodan Jin; Zhuxiu Zhou; Jin Yan; Qiaochan Ou; Xiao Liu; Weidong Li; Yiqing Mao; Weifeng Yao; Tulin Lu
Source:
Journal of ethnopharmacology 2022 v.287 pp. 114911
ISSN:
0378-8741
Subject:
transcription factor NF-kappa B,   etc   ; databases; discriminant analysis; gastric mucosa; indigestion; liquid chromatography; mitogen-activated protein kinase; pharmacology; temperature; traditional medicine;     Show all 10 Subjects
Abstract:
... Processing, also called Paozhi in Chinese, is an ancient Chinese pharmaceutic processing technique developed along with the Chinese herbal medicines (CHMs). The understanding of the mechanism of Paozhi has been investigated for several decades. Aucklandiae Radix (CAR) and its roasted processed products are all used in indigestion as a kind of CHMs. Processed Aucklandiae Radix (PAR) had a stronger ...
DOI:
10.1016/j.jep.2021.114911

9. Eugenol suppresses the proliferation and invasion of TNF-α-induced fibroblast-like synoviocytes via regulating NF-κB and COX-2

Author:
Min Wang; Tianming Dai; Siming Li; Wen Wang
Source:
Biochemical and biophysical research communications 2022 v.612 pp. 63-69
ISSN:
0006-291X
Subject:
transcription factor NF-kappa B,   etc   ; angiogenesis; apoptosis; drugs; eugenol; inflammation; necrosis; neoplasms; prostaglandin synthase; research; rheumatoid arthritis; vascular endothelial growth factors; viability;     Show all 13 Subjects
Abstract:
... Eugenol (4-allyl -2- methoxyphenol), reportedly, a native compound that widely exists in a variety of plants, shows diverse biological activities such as anti-bacteria, anti-inflammation and anti-oxidation. This work was to delve into the effects and molecular mechanisms of eugenol on the phenotypes of fibroblast-like synovial cells from rheumatoid arthritis (RA). Fibroblast-like synovial cells tr ...
DOI:
10.1016/j.bbrc.2022.04.074

10. Thottea siliquosa (Lam.) Ding Hou leaf methanolic extract inhibits lipopolysaccharide-induced TLR4 activation and cytokine production as well as ethyl methyl sulfonate induced genotoxicity

Author:
Alby Tom; Joice Tom Job; Rajakrishnan Rajagopal; Ahmed Alfarhan; Hak-Jae Kim; Young Ock Kim; Sae Won Na; Arunaksharan Narayanankutty
Source:
Physiological and molecular plant pathology 2022 v.117 pp. 101772
ISSN:
0885-5765
Subject:
transcription factor NF-kappa B,   etc   ; Allium cepa; Toll-like receptor 4; genotoxicity; inflammation; interleukin-6; leaves; methanol; mutagens; onions; plant pathology; sulfonates;     Show all 12 Subjects
Abstract:
... Inflammation is the underlying factor for degenerative diseases; hence, targeting inflammatory cascades are of greater importance in preventing these disorders. The traditionally used medical plant Thottea siliquosa is often used against inflammation associated health problems in folk medicines. To provide scientific validation to their traditional uses, the potential of the methanol extract of th ...
DOI:
10.1016/j.pmpp.2021.101772

11. epi-Aszonalenin B from Aspergillus novofumigatus inhibits NF-κB activity induced by ZFTA-RELA fusion protein that drives ependymoma

Author:
Kazuki Ishikawa; Masaki Ishii; Takashi Yaguchi; Toshiaki Katada; Koji Ichinose; Shinya Ohata
Source:
Biochemical and biophysical research communications 2022 v.596 pp. 104-110
ISSN:
0006-291X
Subject:
transcription factor NF-kappa B,   etc   ; Aspergillus; alkaloids; cell lines; fungi; glioma; intercellular adhesion molecule-1; luciferase; pathogenesis; research; therapeutics; zinc finger motif;     Show all 12 Subjects
Abstract:
... Nuclear factor-kappa B (NF-κB) signaling is an intracellular signaling pathway involved in inflammatory responses and the pathogenesis of various cancers, including ependymoma, which is a rare and chemotherapy-resistant glioma. Several isoforms of fusion proteins that consist of a nuclear protein, zinc finger translocation associated (ZFTA), and RELA (ZFTA-RELA), an NF-κB-signaling effector transc ...
DOI:
10.1016/j.bbrc.2022.01.076

12. Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR−/− mice fed a high‐fat/cholesterol diet

Author:
Ruijuan Song; Shufen Han; Hui Gao; Hui Jiang; Xinli Li
Source:
Phytotherapy research 2022 v.36 no.3 pp. 1284-1296
ISSN:
0951-418X
Subject:
transcription factor NF-kappa B,   etc   ; astrocytes; atherosclerosis; blood serum; caspase-1; cognitive disorders; diet; inflammasomes; lipopolysaccharides; mice; occludins; phosphorylation; phytotherapy; protein synthesis; research;     Show all 15 Subjects
Abstract:
... Crocin has been extensively investigated in treating neurodegenerative diseases. However, its effect on cognitive impairment associated with atherosclerosis remains unknown. The present study aimed to explore the potential mechanism of crocin on cognitive impairment in a mouse model of atherosclerosis. LDLR⁻/⁻ mice fed a high‐fat/cholesterol diet were administered variable‐dose crocin for 56 days ...
DOI:
10.1002/ptr.7384

13. Ganoderma lucidum: A potential pleiotropic approach of ganoderic acids in health reinforcement and factors influencing their production

Author:
Md Faruque Ahmad; Shadma Wahab; Fakhruddin Ali Ahmad; Syed Amir Ashraf; Shahabe Saquib Abullais; Hisham H. Saad
Source:
Fungal biology reviews 2022 v.39 pp. 100-125
ISSN:
1749-4613
Subject:
transcription factor NF-kappa B,   etc   ; Ganoderma lucidum; anti-allergic agents; antioxidants; antiretroviral agents; apoptosis; biosynthesis; cell cycle checkpoints; cytotoxicity; medicinal fungi; mycology; polysaccharides;     Show all 12 Subjects
Abstract:
... Ganoderma lucidum (G. lucidum) main attractive pharmacological characteristics are antitumor and immunomodulatory activities which are chiefly associated with its two principal bioactive compounds, those are polysaccharides and triterpenoids. Ganoderic acids (GAs) are one of the most discovered triterpenoids of G. lucidum among various triterpenoids. The prominent medicinal mushroom G. lucidum pos ...
DOI:
10.1016/j.fbr.2021.12.003

14. Structural characterization and anti-inflammatory properties of green synthesized chitosan/compound K‑gold nanoparticles

Author:
Xiao-jie Mi; Han Sol Choi; Hye-Ryung Park; Yeon Ju Kim
Source:
International journal of biological macromolecules 2022 v.213 pp. 247-258
ISSN:
0141-8130
Subject:
transcription factor NF-kappa B,   etc   ; anti-inflammatory agents; biosynthesis; chitosan; cytotoxicity; fluorescence; ginsenosides; interleukin-6; lipopolysaccharides; nanogold; physicochemical properties; secretion; ultraviolet-visible spectroscopy;     Show all 13 Subjects
Abstract:
... Ginsenoside compound K (CK) has been shown to exhibit anti-inflammatory properties. In this study, to encourage biomedical applications of biosynthesized gold nanoparticles (AuNPs) with anti-inflammatory effects, AuNPs loaded with ginsenoside compound K were prepared using a self-assembly technique with chitosan as the carrier. Optimal conditions for chitosan-ginsenoside CK‑gold nanoparticles (CS- ...
DOI:
10.1016/j.ijbiomac.2022.05.177

15. Jujube peel polyphenols synergistically inhibit lipopolysaccharide-induced inflammation through multiple signaling pathways in RAW 264.7 cells

Author:
Dongbei Shen; Caie Wu; Gongjian Fan; Tingting Li; Jinfeng Dou; Jinpeng Zhu; Chunmei Li; Xiuying Kou
Source:
Food and chemical toxicology 2022 v.164 pp. 113062
ISSN:
0278-6915
Subject:
transcription factor NF-kappa B,   etc   ; Ziziphus; catechin; cytoplasm; inflammation; interleukin-6; lipopolysaccharides; mitogen-activated protein kinase; oxidative stress; p-coumaric acid; polyphenols; rutin; synergism; toxicology;     Show all 14 Subjects
Abstract:
... Jujube has great potential as food and traditional drugs in several countries. To study the anti-inflammatory influence of jujube peel polyphenols in lipopolysaccharide (LPS) induced RAW 264.7 cells through mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB) and nuclear erythroid 2-related factor 2 (Nrf2) signaling pathways. In this study, the phenolic composition of polyphenol ...
DOI:
10.1016/j.fct.2022.113062

16. Linoleic acid reduces apoptosis via NF-κB during the in vitro development of induced parthenogenic porcine embryos

Author:
Dong-Kyung Lee; Kwang-Hwan Choi; Jong-Nam Oh; Seung-Hun Kim; Mingyun Lee; Jinsol Jeong; Gyung Cheol Choe; Chang-Kyu Lee
Source:
Theriogenology 2022 v.187 pp. 173-181
ISSN:
0093-691X
Subject:
transcription factor NF-kappa B,   etc   ; ammonium; animal reproduction; apoptosis; blastocyst; embryogenesis; energy; gene expression; genes; interleukin-6; linoleic acid; polyunsaturated fatty acids; protein synthesis; swine;     Show all 14 Subjects
Abstract:
... Fatty acid has a various role in preimplantation embryo development. Especially, Linoleic acid, polyunsaturated fatty acid, has been reported to affect the apoptosis pathway via nuclear transcription factor-kappa B. But to date, the function of NF-κB has not been demonstrated in porcine preimplantation embryos. We demonstrated that linoleic acid had a positive effect on embryo development at a cer ...
DOI:
10.1016/j.theriogenology.2022.05.003

17. Acanthoic acid, unique potential pimaradiene diterpene isolated from Acanthopanax koreanum Nakai (Araliaceae): A review on its pharmacology, molecular mechanism, and structural modification

Author:
Jia-Yi Dou; Yu-Chen Jiang; Zhen-Yu Cui; Li-Hua Lian; Ji-Xing Nan; Yan-Ling Wu
Source:
Phytochemistry 2022 v.200 pp. 113247
ISSN:
0031-9422
Subject:
transcription factor NF-kappa B,   etc   ; AMP-activated protein kinase; Eleutherococcus gracilistylus; Toll-like receptor 4; bark; cardioprotective effect; diterpenoids; gastrointestinal system; interleukin-1; liver; plant biochemistry;     Show all 11 Subjects
Abstract:
... Acanthoic acid (AA) is a pimaradiene diterpene isolated from the root bark of Acanthopanax koreanum Nakai (Araliaceae) with a wide range of pharmacological activities, including anti-cancer, anti-inflammatory, anti-diabetes, liver protection, gastrointestinal protection, and cardiovascular protection. In addition, AA promotes its pharmacological effects by targeting liver X receptors (LXRs), nucle ...
DOI:
10.1016/j.phytochem.2022.113247

18. Immunosuppression participated in complement activation-mediated inflammatory injury caused by 4-octylphenol via TLR7/IκBα/NF-κB pathway in common carp (Cyprinus carpio) gills

Author:
Qi Sun; Yuhao Liu; Xiaojie Teng; Peng Luan; Xiaohua Teng; Xiujie Yin
Source:
Aquatic toxicology 2022 v.249 pp. 106211
ISSN:
0166-445X
Subject:
transcription factor NF-kappa B,   etc   ; CD4-positive T-lymphocytes; Cyprinus carpio; carp; complement; gene expression regulation; immune response; immunosuppression; inflammation; models; pollutants; pollution; risk; toxicity; toxicology;     Show all 15 Subjects
Abstract:
... 4-octylphenol (4-OP), a toxic estrogenic environmental pollutant, can threaten aquatic animal and human health. However, toxic effect of 4-OP on fish has not been reported. To investigate molecular mechanism of gill poisoning caused by 4-OP exposure, a carp 4-OP poisoning model was established, and then blood and gills were collected on day 60. The results demonstrated that gill was a target organ ...
DOI:
10.1016/j.aquatox.2022.106211

19. Korean Red Ginseng attenuates Di-(2-ethylhexyl) phthalate-induced inflammatory response in endometrial cancer cells and an endometriosis mouse model

Author:
Heewon Song; Ji Eun Won; Jeonggeun Lee; Hee Dong Han; YoungJoo Lee
Source:
Journal of Ginseng Research 2022 v.46 no.4 pp. 592-600
ISSN:
1226-8453
Subject:
transcription factor NF-kappa B,   etc   ; Panax; endometriosis; gene expression; immunohistochemistry; inflammation; mice; mitogen-activated protein kinase; phthalates; plasticizers; prostaglandin synthase; research; sequence analysis; therapeutics; uterine neoplasms;     Show all 15 Subjects
Abstract:
... Di-(2-ethylhexyl) phthalate (DEHP) is the most common endocrine disrupting chemical used as a plasticizer. DEHP is associated with the development of endometrium-related diseases through the induction of inflammation. The major therapeutic approaches against endometrial cancer and endometriosis involve the suppression of inflammatory response. Korean Red Ginseng (KRG) is a natural product with ant ...
DOI:
10.1016/j.jgr.2021.11.006

20. Potential of Helicrysum italicum cultivated in urban environment: SCCO2 extract cytotoxicity & NF-kB activation in HeLa, MCF-7 and MRC-5 cells

Author:
Aleksandra Jovanović Galović; Nataša Jovanović Lješković; Senka Vidović; Jelena Vladić; Zorica Mrkonjić; Slobodan Gigov; Milan Ilić; Vesna Kojić; Dimitar Jakimov; Mire Zloh
Source:
Sustainable chemistry and pharmacy 2022 v.26 pp. 100622
ISSN:
2352-5541
Subject:
transcription factor NF-kappa B,   etc   ; animals; carbon dioxide; continental climates; cytotoxicity; dietary supplements; green chemistry; humidity; phytochemicals; soil; solar radiation; urban areas; urban horticulture; value added;     Show all 14 Subjects
Abstract:
... Urban horticulture and vertical gardens provide many benefits for the population in urban areas. A rational selection of plants in these features can introduce a potential for value-added products including extracts of nutraceuticals. Helichrysum. italicum was grown in the urban environment, on a vertical surface in the form of a green wall. Since the location was in a town with continental climat ...
DOI:
10.1016/j.scp.2022.100622