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1. A split G-quadruplex-specific dinuclear Ir(III) complex for label-free luminescent detection of transcription factor

Author:
Zang, Menghan; Su, Huijuan; Lu, Lihua; Li, Feng
Source:
Talanta 2019 v.202 pp. 259-266
ISSN:
0039-9140
Subject:
transcription factor NF-kappa B,   etc   ; aqueous solutions; blood serum; humans; light intensity; luminescence;     Show all 6 Subjects
Abstract:
... A group of luminescent dinuclear Ir(III) complexes were synthesized to study the application possibility as luminescent G-quadruplex (G4) sensors. According to the results, the dinuclear Ir(III) complexes 1–5 were assessed as selective G4 sensors. Among them, complex 5 not only demonstrates the highest specificity towards G4, but also shows linearly enhanced luminescent intensity with the increase ...
DOI:
10.1016/j.talanta.2019.05.021

2. Serglycin as part of IL-1β induced inflammation in human chondrocytes

Author:
Scuruchi, Michele; D'Ascola, Angela; Avenoso, Angela; Mandraffino G, Giuseppe; Campo S, Salvatore; Campo, Giuseppe M.
Source:
Archives of biochemistry and biophysics 2019 v.669 pp. 80-86
ISSN:
0003-9861
Subject:
transcription factor NF-kappa B,   etc   ; arthritis; cartilage; chondrocytes; humans; inflammation; interleukin-1beta; neoplasms; proteoglycans;     Show all 9 Subjects
Abstract:
... Serglycin (SRGN) is an intracellular proteoglycan produced and secreted by several cell types. The increased expression of SRGN was associated with greater aggressiveness in cancer and inflammation.In this study, we demonstrated that SRGN is increased in human chondrocytes after IL-β stimulation. Furthermore, we found that secreted SRGN was able to bind the CD44 receptor thus participating in the ...
DOI:
10.1016/j.abb.2019.05.021

3. Molecular detection of Hsp90 inhibitor suppressing PCV2 replication in host cells

Author:
Liu, Jie; Ma, Chang; Zhang, Xuliang; You, Jinwei; Dong, Min; Chen, Li; Jiang, Ping; Yun, Shifeng
Source:
Microbial pathogenesis 2019 v.132 pp. 51-58
ISSN:
0882-4010
Subject:
transcription factor NF-kappa B,   etc   ; Porcine circovirus-2; adsorption; cell communication; pathogens; swine;     Show all 6 Subjects
Abstract:
... Porcine Circovirus Type 2 (PCV2) is a pathogen that has the ability to cause devastating disease manifestations in pig populations with major economic implications. Our previous research found that Hsp90 is required for PCV2 production in PK-15 and 3D4/31 cells. The aim of this study was to evaluate the effect of Hsp90 inhibitor regulating PCV2 replication and to explore its underlying mechanism. ...
DOI:
10.1016/j.micpath.2019.04.037

4. Cell-free chromatin: A newly described mediator of systemic inflammation

Author:
Chaudhary, Shahid; Mittra, Indraneel
Source:
Journal of biosciences 2019 v.44 no.2 pp. 32
ISSN:
0250-5991
Subject:
transcription factor NF-kappa B,   etc   ; DNA; DNA damage; apoptosis; chromatin; chronic diseases; genome; genomics; inflammation; therapeutics;     Show all 10 Subjects
Abstract:
... Recent research has shown that cell-free chromatin (cfCh) particles that are released from the billions of cells that die in the body everyday can enter into healthy cells, integrate into their genomes and induce dsDNA breaks and apoptotic responses. Genomic integration of cfCh activates NFκB suggesting a novel mechanism of induction of systemic inflammation. Since DNA damage and inflammation are ...
DOI:
10.1007/s12038-019-9849-7

5. A tranilast and BMP-2 based functional bilayer membrane is effective for the prevention of epidural fibrosis during spinal lamina reconstruction

Author:
HanThese authors contributed equally to this work., Chen; Li, Xunlin; Zhou, Tangjun; Chen, Chen; Zhang, Kai; Yang, Shengbing; Wang, Xin; Tian, Haijun; Zhao, Changqing; Zhao, Jie
Source:
Journal of materials chemistry B 2019 v.7 no.19 pp. 3075-3087
ISSN:
2050-7518
Subject:
transcription factor NF-kappa B,   etc   ; bone formation; fibrosis; laminectomy; mice; models; phosphorylation; rabbits; risk factors;     Show all 9 Subjects
Abstract:
... Failed Back Surgery Syndrome (FBSS) is a common complication of lumbar surgery. There are a multitude of reasons for FBSS including both pre-operative and post-operative risk factors. Epidural fibrosis is one of the major cause of FBSS, with no effective therapeutic treatment for it. In this study, a CS/PLGA–MBG bilayer membrane loaded with tranilast (TNL) and BMP-2 was used to reconstruct the ver ...
DOI:
10.1039/c8tb03071e

6. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

Author:
Tan, Yunhao; Kagan, Jonathan C.
Source:
Cell 2019 v.177 no.2 pp. 384-398.e11
ISSN:
0092-8674
Subject:
transcription factor NF-kappa B,   etc   ; glycolysis; inflammasomes; inflammation; innate immunity; interferons; ligands; organelles; protein kinases;     Show all 9 Subjects
Abstract:
... The signaling organelles of the innate immune system consist of oligomeric protein complexes known as supramolecular organizing centers (SMOCs). Examples of SMOCs include myddosomes and inflammasomes, which respectively induce transcription-dependent and -independent inflammatory responses. The common use of oligomeric structures as signaling platforms suggests multifunctionality, but each SMOC ha ...
DOI:
10.1016/j.cell.2019.01.039

7. Curcumol inhibits colorectal cancer proliferation by targeting miR-21 and modulated PTEN/PI3K/Akt pathways

Author:
Liu, Haowei; Wang, Juan; Tao, Yexing; Li, Xumei; Qin, Jianli; Bai, Zhun; Chi, Bixia; Yan, Wei; Chen, Xu
Source:
Life sciences 2019
ISSN:
0024-3205
Subject:
transcription factor NF-kappa B,   etc   ; Western blotting; colorectal neoplasms; phosphatidylinositol 3-kinase; protein content;     Show all 5 Subjects
Abstract:
... The purpose of this study was to demonstrate how curcumol affected the expression of miR-21 and whether its effects on miR-21 was associated with the activation of PTEN/PI3K/Akt pathways in CRC cells.MTT and xenograft assay were used to examine how curcumol inhibits colorectal cancer (CRC) cells' growth. Q-PCR and western blot analysis were employed to test the role of miR-21 in the inhibition of ...
DOI:
10.1016/j.lfs.2019.02.049

8. The induction of RANKL molecule clustering could stimulate early osteoblast differentiation

Author:
Sone, Eri; Noshiro, Daisuke; Ikebuchi, Yuki; Nakagawa, Mami; Khan, Masud; Tamura, Yukihiko; Ikeda, Masaomi; Oki, Meiko; Murali, Ramachandran; Fujimori, Toshihiko; Yoda, Tetsuya; Honma, Masashi; Suzuki, Hiroshi; Ando, Toshio; Aoki, Kazuhiro
Source:
Biochemical and biophysical research communications 2019 v.509 no.2 pp. 435-440
ISSN:
0006-291X
Subject:
transcription factor NF-kappa B,   etc   ; atomic force microscopy; immunoblotting; immunoglobulin M; ligands; osteoblasts; peptides;     Show all 7 Subjects
Abstract:
... We recently found that the membrane-bound receptor activator of NF-κB ligand (RANKL) on osteoblasts works as a receptor to stimulate osteoblast differentiation, however, the reason why the RANKL-binding molecules stimulate osteoblast differentiation has not been well clarified. Since the induction of cell-surface receptor clustering is known to lead to cell activation, we hypothesized that the ind ...
DOI:
10.1016/j.bbrc.2018.12.093

9. USP14-mediated IκBα degradation exacerbates NF-κB activation and IL-1β-stimulated chondrocyte dedifferentiation

Author:
Li, Ming; Zhao, Jianqiang; Jia, Liang
Source:
Life sciences 2019 v.218 pp. 147-152
ISSN:
0024-3205
Subject:
transcription factor NF-kappa B,   etc   ; IKappaB kinase; cartilage; chondrocytes; inflammation; interleukin-1beta; osteoarthritis; protein degradation;     Show all 8 Subjects
Abstract:
... Osteoarthritis (OA) is an inflammatory joint disease. USP14, a deubiquitinating enzyme critical for ubiquitin-mediated proteasomal protein degradation, is implicated in inflammation regulation. However, its role and mechanism in OA are poorly understood. Here, we report that USP14 is upregulated in OA articular cartilage as well as in chondrocytes treated with IL-1β in vitro. USP14 upregulation de ...
DOI:
10.1016/j.lfs.2018.12.014

10. CDK4 Inhibitors Thwart Immunity by Inhibiting Phospho-RB-NF-κB Complexes

Author:
Kim, Seung J.; Asfaha, Samuel; Dick, Frederick A.
Source:
Molecular cell 2019 v.73 no.1 pp. 1-2
ISSN:
1097-2765
Subject:
transcription factor NF-kappa B,   etc   ; DNA-binding domains; immunity; neoplasm cells;     Show all 4 Subjects
Abstract:
... PD-L1 plays a central role in immune recognition of cancer cells. In this issue of Molecular Cell, Jin et al. (2019) report that a phosphorylated retinoblastoma protein contacts the DNA-binding domain of p65 NF-κB, thereby blocking transcription of PD-L1. ...
DOI:
10.1016/j.molcel.2018.12.012

11. p62/SQSTM1: ‘Jack of all trades’ in health and cancer

Author:
Sánchez‐Martín, Pablo; Saito, Tetsuya; Komatsu, Masaaki
Source:
TheFEBS journal 2019 v.286 no.1 pp. 8-23
ISSN:
1742-464X
Subject:
transcription factor NF-kappa B,   etc   ; autophagy; disease course; droplets; inflammation; liquids; lysosomes; neoplasms; signal transduction;     Show all 9 Subjects
Abstract:
... p62 is a stress‐inducible protein able to change among binding partners, cellular localizations and form liquid droplet structures in a context‐dependent manner. This protein is mainly defined as a cargo receptor for selective autophagy, a process that allows the degradation of detrimental and unnecessary components through the lysosome. Besides this role, its ability to interact with multiple bin ...
DOI:
10.1111/febs.14712

12. Identification of anti-osteoclastogenic compounds from Cleistocalyx operculatus flower buds and their effects on RANKL-induced osteoclastogenesis

Author:
Tran, Phuong Thao; Ngo, Thi Quynh-Mai; Lee, Suhyun; Kim, Okwha; Tran, Huynh Nguyen Khanh; Hwangbo, Cheol; Min, Byung Sun; Lee, Jeong-Hyung
Source:
Journal of functional foods 2019 v.60 pp. 103388
ISSN:
1756-4646
Subject:
transcription factor NF-kappa B,   etc   ; Syzygium nervosum; beverages; bioactive properties; ethanol; flower buds; herbal tea; ingredients; osteoclasts;     Show all 9 Subjects
Abstract:
... Cleistocalyx operculatus flower buds are used as a main ingredient in various beverages and herbal tea in tropical areas. The present study was conducted to investigate anti-osteoclastogenic effects of ethanol extract of C. operculatus flower buds (ECB) and to identify anti-osteoclastogenic compounds in these buds. ECB significantly inhibited RANKL-induced osteoclast differentiation and decreased ...
DOI:
10.1016/j.jff.2019.05.044

13. Schizandrin B attenuates angiotensin II induced endothelial to mesenchymal transition in vascular endothelium by suppressing NF-κB activation

Author:
You, Shengban; Qian, Jianchang; Wu, Gaojun; Qian, Yuanyuan; Wang, Zhengxian; Chen, Taiwei; Wang, Jingying; Huang, Weijian; Liang, Guang
Source:
Phytomedicine 2019 v.62 pp. 152955
ISSN:
0944-7113
Subject:
transcription factor NF-kappa B,   etc   ; Schisandra chinensis; angiotensin II; cytokines; endothelium; fibrosis; inflammation; mice; oxidative stress; phenotype; protective effect;     Show all 11 Subjects
Abstract:
... Angiotensin II (Ang II)-induced chronic inflammation and oxidative stress often leads to irreversible vascular injury, in which the endothelial to mesenchymal transition (EndMT) in the endothelial layers are involved. Schisandrin B (Sch B), a natural product isolated from traditional Schisandra chinensis, has been reported to exert vascular protective properties with unclear mechanism.This study i ...
DOI:
10.1016/j.phymed.2019.152955

14. Benzo[a]pyrene (BaP) exposure generates persistent reactive oxygen species (ROS) to inhibit the NF-κB pathway in medaka (Oryzias melastigma)

Author:
Cui, Qian; Chen, Fang-Yi; Chen, Hui-Yun; Peng, Hui; Wang, Ke-Jian
Source:
Environmental pollution 2019 v.251 pp. 502-509
ISSN:
0269-7491
Subject:
transcription factor NF-kappa B,   etc   ; Oryzias melastigma; benzo(a)pyrene; cell lines; hepatocytes; hydrogen peroxide; immune response; pollutants; signal transduction;     Show all 9 Subjects
Abstract:
... Benzo[a]pyrene (BaP), a common environmental pollutant, can modulate the immune-associated signal pathway NF-κB, which is one of the critical signal pathways involved in various immune responses. BaP exposure usually generates reactive oxygen species (ROS), but whether ROS are predominantly involved in the modulation mechanism of the NF-κB pathway has not been clearly understood. In this study, an ...
DOI:
10.1016/j.envpol.2019.04.063

15. CD133 promotes the self-renewal capacity of thyroid cancer stem cells through activation of glutamate aspartate transporter SLC1A3 expression

Author:
Wang, Cong; Wang, Zhenglin; Liu, Wei; Ai, Zhilong
Source:
Biochemical and biophysical research communications 2019 v.511 no.1 pp. 87-91
ISSN:
0006-291X
Subject:
transcription factor NF-kappa B,   etc   ; aspartic acid; glutamic acid; neoplasm cells; stem cells; thyroid neoplasms; transcription (genetics);     Show all 7 Subjects
Abstract:
... CD133+ cancer stem cells are responsible for thyroid cancer initiation. The regulatory pathways essential for sustaining the self-renewal of thyroid cancer stem cells remain largely unknown. Glutamate signaling regulates the self-renewal ability of stem cells. In the present study, we found that the level of glutamate was higher in CD133+ thyroid cancer cells than in CD133- thyroid cancer cells. T ...
DOI:
10.1016/j.bbrc.2019.02.023

16. HDAC5 promotes Mycoplasma pneumoniae-induced inflammation in macrophages through NF-κB activation

Author:
Zhao, Yuehua; Ma, Guorui; Yang, Xingge
Source:
Life sciences 2019 v.221 pp. 13-19
ISSN:
0024-3205
Subject:
transcription factor NF-kappa B,   etc   ; Mycoplasma pneumoniae; children; cytokines; histone deacetylase; immunity; inflammation; macrophages; mononuclear leukocytes; pathophysiology; pneumonia;     Show all 11 Subjects
Abstract:
... Excessive inflammation is fundamental in the pathophysiology of Mycoplasma pneumoniae (MP)-induced respiratory infection in children. Histone deacetylase 5 (HDAC5) is involved in the regulation of inflammation, however, whether it associates with immunity against MP infection is not determined. We report here that HDAC5 expression is decreased in peripheral blood mononuclear cells (PBMCs) from Myc ...
DOI:
10.1016/j.lfs.2019.02.004

17. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling

Author:
Katsuya, Ken; Oikawa, Daisuke; Iio, Kiyosei; Obika, Shingo; Hori, Yuji; Urashima, Toshiki; Ayukawa, Kumiko; Tokunaga, Fuminori
Source:
Biochemical and biophysical research communications 2019 v.509 no.3 pp. 700-706
ISSN:
0006-291X
Subject:
transcription factor NF-kappa B,   etc   ; cell viability; cytotoxicity; enzyme activity; inflammation; inhibitory concentration 50; ubiquitin; ubiquitin-protein ligase; ubiquitination;     Show all 9 Subjects
Abstract:
... Nuclear factor-κB (NF-κB) is a crucial transcription factor family involved in the regulation of immune and inflammatory responses and cell survival. The linear ubiquitin chain assembly complex (LUBAC), composed of the HOIL-1L, HOIP, and SHARPIN subunits, specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-κB pathway. We re ...
DOI:
10.1016/j.bbrc.2018.12.164

18. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

Author:
Georgouli, Mirella; Herraiz, Cecilia; Crosas-Molist, Eva; Fanshawe, Bruce; Maiques, Oscar; Perdrix, Anna; Pandya, Pahini; Rodriguez-Hernandez, Irene; Ilieva, Kristina M.; Cantelli, Gaia; Karagiannis, Panagiotis; Mele, Silvia; Lam, Hoyin; Josephs, Debra H.; Matias-Guiu, Xavier; Marti, Rosa M.; Nestle, Frank O.; Orgaz, Jose L.; Malanchi, Ilaria; Fruhwirth, Gilbert O.; Karagiannis, Sophia N.; Sanz-Moreno, Victoria
Source:
Cell 2019 v.176 no.4 pp. 757-774.e23
ISSN:
0092-8674
Subject:
transcription factor NF-kappa B,   etc   ; biopsy; humans; interleukin-1alpha; macrophages; melanoma; metastasis; models; monocytes; myosin; neoplasm cells; proteomics; secretion;     Show all 13 Subjects
Abstract:
... ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to CD206+CD163+ tumor-associated macrophages and vessels. Proteomic analysis shows that ROCK-Myosin II activity in amoeboid ...
DOI:
10.1016/j.cell.2018.12.038

19. Interleukin 4 inhibits high mobility group box-1 protein-mediated NLRP3 inflammasome formation by activating peroxisome proliferator-activated receptor-γ in astrocytes

Author:
Yao, Xiaolong; Jiang, Qian; Ding, Wei; Yue, Pengjie; Wang, Junwen; Zhao, Kai; Zhang, Huaqiu
Source:
Biochemical and biophysical research communications 2019 v.509 no.2 pp. 624-631
ISSN:
0006-291X
Subject:
transcription factor NF-kappa B,   etc   ; Western blotting; astrocytes; caspase-1; fluorescent antibody technique; inflammasomes; interleukin-4; nucleoproteins;     Show all 8 Subjects
Abstract:
... High mobility group box-1 protein (HMGB-1) is one of the most important DAMPs and has been previously shown to promote the formation of the NOD-like receptor with pyrin domain containing-3 (NLRP3) inflammasome in microglia. Interleukin 4 (IL4) is a Th2-derived cytokine that plays a significant role in the function of various immune cells. However, the underlying molecular mechanism by which IL4 si ...
DOI:
10.1016/j.bbrc.2018.11.145

20. Essential element Cu and non-essential element Hg exposures have different toxicological effects in the liver of large yellow croaker

Author:
Zeng, Lin; Ai, Chunxiang; Zhang, Jianshe; Zheng, Jialang
Source:
Marine pollution bulletin 2019 v.139 pp. 6-13
ISSN:
0025-326X
Subject:
transcription factor NF-kappa B,   etc   ; Larimichthys crocea; biomarkers; copper; fish; immune response; inflammation; liver; mercury; reactive oxygen species; water pollution;     Show all 11 Subjects
Abstract:
... The objective was to compare the different effects of essential element Cu and non-essential element Hg on antioxidant and inflammatory responses in the liver of large yellow croaker Larimichthys crocea. Fish were exposed to Cu stresses (72 and 288 μg L−1) and Hg stresses (14 and 56 μg L−1) for 96 h. High-dose Cu increased metallothioneins (MTs) levels and immune defenses in response to elevated r ...
DOI:
10.1016/j.marpolbul.2018.12.029