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1. Enhancing the performance of sterile filtration for viral vaccines and model nanoparticles using an appropriate prefilter

Author:
Neil Taylor; Wanli (Justin) Ma; Adam Kristopeit; Sheng-Ching Wang; Andrew L. Zydney
Source:
Journal of membrane science 2022 v.647 pp. 120264
ISSN:
0376-7388
Subject:
live vaccines; viral vaccines,   etc   ; bioprocessing; filtration; porosity;     Show all 5 Subjects
Abstract:
... Prefilters are widely used to enhance the performance of normal flow filtration steps in bioprocessing; however little is known about the potential benefits of prefiltration in the sterile filtration of viral vaccines and other large particle biotherapeutics. Sterile filtration experiments were performed with a live-attenuated viral vaccine and model nanoparticle suspension, both of which have a s ...
DOI:
10.1016/j.memsci.2022.120264

2. Effectiveness of Live-Attenuated Genotype III Japanese Encephalitis Viral Vaccine against Circulating Genotype I Viruses in Swine

Author:
Yi-Chin Fan; Yi-Ying Chen; Jo-Mei Chen; Chienjin Huang; Mei Huang; Shyan-Song Chiou
Source:
Viruses 2022 v.14 no.1 pp. -
ISSN:
1999-4915
Subject:
live vaccines; viral vaccines,   etc   ; encephalitis; fetal death; genotype; public health; viruses;     Show all 7 Subjects
Abstract:
... Expansion of genotype I (GI) Japanese encephalitis viruses (JEV) has resulted in the replacement of the dominant genotype III (GIII) viruses, raising serious public health concerns for using GIII virus-derived vaccines to effectively control JEV epidemics. Therefore, this study used swine as the model to estimate the effectiveness of GIII live-attenuated vaccine against GI virus infection by compa ...
DOI:
10.3390/v14010114

3. Pacific Eclipse exercise: Value to US Indo-Pacific Command Surgeon’s Office

Author:
Louis C. Tripoli
Source:
Vaccine 2022 v.40 no.17 pp. 2476-2477
ISSN:
0264-410X
Subject:
vaccines,   etc   ; exercise; pandemic;     Show all 3 Subjects
Abstract:
... The United States Indo-Pacific Command Surgeon Office had the opportunity to participate in the Pacific Eclipse workshop in December 2019. This paper discusses the value of the exercise in pandemic and disaster planning for the US Indo-Pacific Command. ...
DOI:
10.1016/j.vaccine.2021.11.012

4. Motivational interviewing and vaccine acceptance in children: The MOTIVE study

Author:
Justin W. Cole; Aleda M.H. Chen; Kalista McGuire; Sarah Berman; Julia Gardner; Yamini Teegala
Source:
Vaccine 2022 v.40 no.12 pp. 1846-1854
ISSN:
0264-410X
Subject:
vaccines,   etc   ; childhood; insurance; vaccination;     Show all 4 Subjects
Abstract:
... Vaccine coverage have been less than desired in young children in part due to parental vaccine hesitancy. Addressing health beliefs through patient-centered communication approaches such as motivational interviewing (MI) may improve vaccine confidence. Thus, the objective of this study was to determine the difference in paediatric vaccination coverage rates based on the Advisory Committee on Immun ...
DOI:
10.1016/j.vaccine.2022.01.058

5. Did the European suspension of the AstraZeneca vaccine decrease vaccine acceptance during the COVID-19 pandemic?

Author:
Michael Bang Petersen; Frederik Jørgensen; Marie Fly Lindholt
Source:
Vaccine 2022 v.40 no.4 pp. 558-561
ISSN:
0264-410X
Subject:
vaccines,   etc   ; COVID-19 infection; pandemic;     Show all 3 Subjects
Abstract:
... On March 11, 2021, the AstraZeneca vaccine against COVID-19 was suspended in three Nordic countries and, on subsequent days, in other European countries. Using data on vaccine acceptance in eight Western countries obtained on a daily basis, we show that these decisions - and associated news - decreased public vaccine acceptance in several countries and part of this decrease happened in response to ...
DOI:
10.1016/j.vaccine.2021.12.026

6. Modeling the long-term 2-8 °C stability profiles of a live, rotavirus vaccine candidate (RV3-BB) in various liquid formulations via extrapolations of real-time and accelerated stability data

Author:
Swathi R. Pullagurla; Prashant Kumar; Oluwadara Ogun; Ozan S. Kumru; Ahd Hamidi; Femke Hoeksema; Christopher Yallop; Julie E. Bines; David B. Volkin; Sangeeta B. Joshi
Source:
Biologicals 2022 v.75 pp. 21-28
ISSN:
1045-1056
Subject:
vaccines,   etc   ; liquids; storage quality; temperature;     Show all 4 Subjects
Abstract:
... To accelerate the formulation development of live-virus vaccine (LVV) candidates, more rapid approaches to rank-order formulations and estimate their real-time storage stability losses are needed. In this case-study, we utilize new and previously described stability data of a live, rotavirus vaccine candidate (RV3-BB) in three different liquid formulations to model and compare predicted vs. experi ...
DOI:
10.1016/j.biologicals.2021.12.001

7. Special Issue “Recent Progress in Hepatitis A Virus Research”

Author:
Sébastien Lhomme
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
vaccines,   etc   ; Hepatovirus A; viral hepatitis;     Show all 3 Subjects
Abstract:
... The hepatitis A virus (HAV) is still one of the leading causes of acute viral hepatitis worldwide, despite there being an anti-HAV vaccine [...] ...
DOI:
10.3390/v14061138

8. The vaccine equity crisis is a stress test for all future major environmental challenges

Author:
Pier Luigi Sacco
Source:
Science of the total environment 2022 v.825 pp. 154073
ISSN:
0048-9697
Subject:
vaccines,   etc   ; climate; environment; pandemic; politics;     Show all 5 Subjects
Abstract:
... The vaccine equity crisis has an extra element that makes it crucial for our capacity to tackle future major societal challenges. Unlike most of these, including the climate one, the current pandemic causes major damage that is directly observable in the very short term, that is, within the political cycle of the incumbent policymakers. If not even this kind of crisis with directly observable dama ...
DOI:
10.1016/j.scitotenv.2022.154073

9. Vaccine misinformation types and properties in Russian troll tweets

Author:
Echo L. Warner; Juliana L. Barbati; Kaylin L. Duncan; Kun Yan; Stephen A. Rains
Source:
Vaccine 2022 v.40 no.6 pp. 953-960
ISSN:
0264-410X
Subject:
vaccines,   etc   ; confidence interval; languages; misinformation;     Show all 4 Subjects
Abstract:
... To identify the content of and engagement with vaccine misinformation from Russian trolls on Twitter. Troll tweets (N = 1959) obtained from Twitter in 2020 were coded for vaccine misinformation (α = 0.77–0.97). Descriptive, bivariate, and multivariable negative binomial regressions were applied to estimate robust incidence rate ratios (IRRs) and 95% confidence intervals (95 %CI) of vaccine misinfo ...
DOI:
10.1016/j.vaccine.2021.12.040

10. Development of an indirect competitive enzyme linked immunosorbent assay for the quantitative detection of Mycoplasma hyopneumoniae during the vaccine production process

Author:
Yanna Wei; Thandeka Khoza; Yanfei Yu; Li Wang; Beibei Liu; Jia Wang; Lanxi Gan; Fei Hao; Guoqing Shao; Zhixin Feng; Qiyan Xiong
Source:
Journal of immunological methods 2022 v.500 pp. 113196
ISSN:
0022-1759
Subject:
inactivated vaccines; live vaccines,   etc   ; Mycoplasma hyopneumoniae; antigens; color; enzymes; equations; peptide elongation factors; polyclonal antibodies; regression analysis;     Show all 10 Subjects
Abstract:
... Inactivated Mycoplasma hyopneumoniae vaccine is used extensively to control M. hyopneumoniae infection worldwide. Quantification techniques are essential in the process of standardizing and validating vaccines. In this study, we developed and optimized an indirect competitive enzyme linked immunosorbent assay (ic-ELISA) for the rapid quantification of M. hyopneumoniae antigen during vaccine produc ...
DOI:
10.1016/j.jim.2021.113196

11. Enhanced High Mutation Rate and Natural Selection to Produce Attenuated Viral Vaccine with CRISPR Toolkit in RNA Viruses especially SARS-CoV-2

Author:
Saleh Jamehdor; Sina Naserian; Ali Teimoori
Source:
Infection, genetics, and evolution 2022 v.97 pp. 105188
ISSN:
1567-1348
Subject:
live vaccines; viral vaccines,   etc   ; RNA; Severe acute respiratory syndrome coronavirus 2; coculture; genome; infection; mutation rate; natural selection;     Show all 9 Subjects
Abstract:
... The best and most effective way to combat pandemics is to use effective vaccines and live attenuated vaccines are among the most effective vaccines. However, one of the major problems is the length of time it takes to get the attenuated vaccines. Today, the CRISPR toolkit (Clustered Regularly Inerspaced Short Palindromic Repeats) has made it possible to make changes with high efficiency and speed. ...
DOI:
10.1016/j.meegid.2021.105188

12. Couples and COVID-19 vaccination: Frequency and reasons for discordance

Author:
Karen B. Schmaling
Source:
Vaccine 2022 v.40 no.13 pp. 1913-1917
ISSN:
0264-410X
Subject:
vaccines,   etc   ; COVID-19 infection; surveys; vaccination;     Show all 4 Subjects
Abstract:
... The purpose of this study was to determine the frequency of concordance and discordance in the COVID-19 vaccination status of intimate couples. Partners are well known to influence each other’s health behaviors, but previous reports of couples’ COVID-19 vaccination status were not found. Among 1305 respondents to an on-line survey who were living with their partners, couples’ COVID-19 vaccination ...
DOI:
10.1016/j.vaccine.2022.02.055

13. Monitoring vaccine safety using the vaccine safety Datalink: Assessing capacity to integrate data from Immunization Information systems

Author:
Holly C. Groom; Bradley Crane; Allison L. Naleway; Eric Weintraub; Matthew F. Daley; Kris Wain; Mary Beth Kurilo; Rachael Burganowski; Malini B. DeSilva; James G. Donahue; Sungching C. Glenn; Kristin Goddard; Michael L. Jackson; Elyse O. Kharbanda; Ned Lewis; Yingbo Lou; Marlene Lugg; Erica Scotty; Lina S. Sy; Joshua T.B. Williams; Stephanie A. Irving
Source:
Vaccine 2022 v.40 no.5 pp. 752-756
ISSN:
0264-410X
Subject:
vaccines,   etc   ; COVID-19 infection; telemedicine; vaccination;     Show all 4 Subjects
Abstract:
... The Vaccine Safety Datalink (VSD) uses vaccination data from electronic health records (EHR) at eight integrated health systems to monitor vaccine safety. Accurate capture of data from vaccines administered outside of the health system is critical for vaccine safety research, especially for COVID-19 vaccines, where many are administered in non-traditional settings. However, timely access and inclu ...
DOI:
10.1016/j.vaccine.2021.12.048

14. A retrospective analysis of social media posts pertaining to COVID-19 vaccination side effects

Author:
Max-Philipp Lentzen; Viola Huebenthal; Rolf Kaiser; Matthias Kreppel; Joachim E. Zoeller; Matthias Zirk
Source:
Vaccine 2022 v.40 no.1 pp. 43-51
ISSN:
0264-410X
Subject:
vaccines,   etc   ; COVID-19 infection; retrospective studies; vaccination;     Show all 4 Subjects
Abstract:
... With an uprising influence of social media platforms like Twitter and Instagram a multitude of worldwide accessible information is available. Since the beginning of COVID-19 pandemic the exchange of medical information about several topics related to this infectious disease and its vaccination has increased rapidly. The purpose of this investigation was to assess the content associated with COVID- ...
DOI:
10.1016/j.vaccine.2021.11.052

15. Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?

Author:
Hazel M. Dockrell; Egle Butkeviciute
Source:
Vaccine 2022 v.40 no.11 pp. 1525-1533
ISSN:
0264-410X
Subject:
live vaccines,   etc   ; BCG vaccine; immunogenicity; tuberculosis; vaccination;     Show all 5 Subjects
Abstract:
... The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and whether this new information can be exploited to improve its efficacy, by enhancing its ability to induce either antige ...
DOI:
10.1016/j.vaccine.2021.01.068

16. Components of a HIV-1 vaccine mediate virus-like particle (VLP)-formation and display of envelope proteins exposing broadly neutralizing epitopes

Author:
Jamila Franca Rosengarten; Stefanie Schatz; Tobias Wolf; Stephan Barbe; Jörn Stitz
Source:
Virology 2022 v.568 pp. 41-48
ISSN:
0042-6822
Subject:
vaccines,   etc   ; epitopes; gene transfer; sequence diversity; virology;     Show all 5 Subjects
Abstract:
... The sequence diversity of HIV-1 is the biggest hurdle for the design of a prophylactic vaccine. Mosaic (Mos) antigens consisting of synthetically shuffled epitopes from various HIV-1 strains are currently tested in the clinical vaccine trial Mosaico (NCT03964415). Besides adenovirus vectors encoding variants of Mos.Gag-Pol and soluble Mos.Env proteins, the Mosaico vaccine entails vectors mediating ...
DOI:
10.1016/j.virol.2022.01.008

17. Dendrimers in vaccine delivery: Recent progress and advances

Author:
Silvia Chowdhury; Istvan Toth; Rachel J. Stephenson
Source:
Biomaterials 2022 v.280 pp. 121303
ISSN:
0142-9612
Subject:
vaccines,   etc   ; adjuvants; biocompatible materials; dendrimers; evolution; peptides;     Show all 6 Subjects
Abstract:
... Dendrimers are well-defined, highly branched, multivalent and monodisperse molecules which host a range of attractive, yet functional, chemical and biological characteristics. A dendrimers accessible surface groups enable coupling to different functional moieties (e.g., antibodies, peptides, proteins, etc), which is further assisted by the dendrimers tailored size and surface charge. This adaptabi ...
DOI:
10.1016/j.biomaterials.2021.121303

18. Glycoconjugate content quantification to assess vaccine potency: A simplified approach

Author:
Francesca Rech; Riccardo De Ricco; Sara Giannini; Luca Nompari; Marilena Paludi; Stefania Berti; Chiara Parlati; Simona Cianetti; Francesco Berti
Source:
Biologicals 2022 v.76 pp. 10-14
ISSN:
1045-1056
Subject:
vaccines,   etc   ; antigens; phosphates; polysaccharides; product quality; serotypes;     Show all 6 Subjects
Abstract:
... Several glycoconjugate vaccines have been licensed or are currently in clinical development to prevent bacterial infections. Here we report the development of a single analytical assay to quantify the conjugated saccharide content, as alternative to two separated total and free (unconjugated) saccharide assays used so far, for a quadrivalent conjugate vaccine containing meningococcal serogroup A p ...
DOI:
10.1016/j.biologicals.2022.02.004

19. HPV vaccination coverage in three districts in Zimbabwe following national introduction of 0,12 month schedule among 10 to 14 year old girls

Author:
D. Scott LaMontagne; Portia Manangazira; Joan Marembo; Colline Chigodo; Coscar Zvamashakwe; Emma Tshuma; Evelyn Marima; Kenneth Chindedza; Ernest Ndlela; Jessica Mooney
Source:
Vaccine 2022 v.40 pp. A58
ISSN:
0264-410X
Subject:
vaccines,   etc   ; surveys; uterine cervical neoplasms; vaccination; Zimbabwe;     Show all 5 Subjects
Abstract:
... Zimbabwe has one of the highest incidence rates of cervical cancer in the world – 61.7 per 100,000 women. The government of Zimbabwe introduced bivalent HPV vaccine with a 0,12 month schedule to all 10–14 year old girls using a pulsed-campaign approach in May 2018 (dose 1) and May 2019 (dose 2). In August 2019, we conducted a population-based, two-stage cluster survey of households with girls who ...
DOI:
10.1016/j.vaccine.2021.07.012

20. Human Papillomavirus Vaccine Effectiveness by Number of Doses: Updated Systematic Review of Data from National Immunization Programs

Author:
Lauri E. Markowitz; Mélanie Drolet; Rayleen Lewis; Philippe Lemieux-Mellouki; Norma Perez; Mark Jit; Julia M. Brotherton; Gina Ogilvie; Aimée R. Kreimer; Marc Brisson
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
vaccines,   etc   ; Papillomaviridae; humans; risk; systematic review; vaccination;     Show all 6 Subjects
Abstract:
... Human papillomavirus (HPV) vaccines were first licensed as a three-dose series. Two doses are now widely recommended in some age groups; there are data suggesting high efficacy with one dose. We updated a systematic literature review of HPV vaccine effectiveness by number of doses in observational studies. We searched Medline and Embase databases from January 1, 2007, through September 29, 2021. D ...
DOI:
10.1016/j.vaccine.2022.06.065