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live vaccines; viral vaccines, etc ; bioprocessing; filtration; porosity; Show all 5 Subjects
Abstract:
... Prefilters are widely used to enhance the performance of normal flow filtration steps in bioprocessing; however little is known about the potential benefits of prefiltration in the sterile filtration of viral vaccines and other large particle biotherapeutics. Sterile filtration experiments were performed with a live-attenuated viral vaccine and model nanoparticle suspension, both of which have a s ...
live vaccines; viral vaccines, etc ; encephalitis; fetal death; genotype; public health; viruses; Show all 7 Subjects
Abstract:
... Expansion of genotype I (GI) Japanese encephalitis viruses (JEV) has resulted in the replacement of the dominant genotype III (GIII) viruses, raising serious public health concerns for using GIII virus-derived vaccines to effectively control JEV epidemics. Therefore, this study used swine as the model to estimate the effectiveness of GIII live-attenuated vaccine against GI virus infection by compa ...
... The United States Indo-Pacific Command Surgeon Office had the opportunity to participate in the Pacific Eclipse workshop in December 2019. This paper discusses the value of the exercise in pandemic and disaster planning for the US Indo-Pacific Command. ...
... Vaccine coverage have been less than desired in young children in part due to parental vaccine hesitancy. Addressing health beliefs through patient-centered communication approaches such as motivational interviewing (MI) may improve vaccine confidence. Thus, the objective of this study was to determine the difference in paediatric vaccination coverage rates based on the Advisory Committee on Immun ...
... On March 11, 2021, the AstraZeneca vaccine against COVID-19 was suspended in three Nordic countries and, on subsequent days, in other European countries. Using data on vaccine acceptance in eight Western countries obtained on a daily basis, we show that these decisions - and associated news - decreased public vaccine acceptance in several countries and part of this decrease happened in response to ...
Swathi R. Pullagurla; Prashant Kumar; Oluwadara Ogun; Ozan S. Kumru; Ahd Hamidi; Femke Hoeksema; Christopher Yallop; Julie E. Bines; David B. Volkin; Sangeeta B. Joshi
... To accelerate the formulation development of live-virus vaccine (LVV) candidates, more rapid approaches to rank-order formulations and estimate their real-time storage stability losses are needed. In this case-study, we utilize new and previously described stability data of a live, rotavirus vaccine candidate (RV3-BB) in three different liquid formulations to model and compare predicted vs. experi ...
... The hepatitis A virus (HAV) is still one of the leading causes of acute viral hepatitis worldwide, despite there being an anti-HAV vaccine [...] ...
vaccines, etc ; climate; environment; pandemic; politics; Show all 5 Subjects
Abstract:
... The vaccine equity crisis has an extra element that makes it crucial for our capacity to tackle future major societal challenges. Unlike most of these, including the climate one, the current pandemic causes major damage that is directly observable in the very short term, that is, within the political cycle of the incumbent policymakers. If not even this kind of crisis with directly observable dama ...
vaccines, etc ; confidence interval; languages; misinformation; Show all 4 Subjects
Abstract:
... To identify the content of and engagement with vaccine misinformation from Russian trolls on Twitter. Troll tweets (N = 1959) obtained from Twitter in 2020 were coded for vaccine misinformation (α = 0.77–0.97). Descriptive, bivariate, and multivariable negative binomial regressions were applied to estimate robust incidence rate ratios (IRRs) and 95% confidence intervals (95 %CI) of vaccine misinfo ...
inactivated vaccines; live vaccines, etc ; Mycoplasma hyopneumoniae; antigens; color; enzymes; equations; peptide elongation factors; polyclonal antibodies; regression analysis; Show all 10 Subjects
Abstract:
... Inactivated Mycoplasma hyopneumoniae vaccine is used extensively to control M. hyopneumoniae infection worldwide. Quantification techniques are essential in the process of standardizing and validating vaccines. In this study, we developed and optimized an indirect competitive enzyme linked immunosorbent assay (ic-ELISA) for the rapid quantification of M. hyopneumoniae antigen during vaccine produc ...
live vaccines; viral vaccines, etc ; RNA; Severe acute respiratory syndrome coronavirus 2; coculture; genome; infection; mutation rate; natural selection; Show all 9 Subjects
Abstract:
... The best and most effective way to combat pandemics is to use effective vaccines and live attenuated vaccines are among the most effective vaccines. However, one of the major problems is the length of time it takes to get the attenuated vaccines. Today, the CRISPR toolkit (Clustered Regularly Inerspaced Short Palindromic Repeats) has made it possible to make changes with high efficiency and speed. ...
vaccines, etc ; COVID-19 infection; surveys; vaccination; Show all 4 Subjects
Abstract:
... The purpose of this study was to determine the frequency of concordance and discordance in the COVID-19 vaccination status of intimate couples. Partners are well known to influence each other’s health behaviors, but previous reports of couples’ COVID-19 vaccination status were not found. Among 1305 respondents to an on-line survey who were living with their partners, couples’ COVID-19 vaccination ...
Holly C. Groom; Bradley Crane; Allison L. Naleway; Eric Weintraub; Matthew F. Daley; Kris Wain; Mary Beth Kurilo; Rachael Burganowski; Malini B. DeSilva; James G. Donahue; Sungching C. Glenn; Kristin Goddard; Michael L. Jackson; Elyse O. Kharbanda; Ned Lewis; Yingbo Lou; Marlene Lugg; Erica Scotty; Lina S. Sy; Joshua T.B. Williams; Stephanie A. Irving
vaccines, etc ; COVID-19 infection; telemedicine; vaccination; Show all 4 Subjects
Abstract:
... The Vaccine Safety Datalink (VSD) uses vaccination data from electronic health records (EHR) at eight integrated health systems to monitor vaccine safety. Accurate capture of data from vaccines administered outside of the health system is critical for vaccine safety research, especially for COVID-19 vaccines, where many are administered in non-traditional settings. However, timely access and inclu ...
vaccines, etc ; COVID-19 infection; retrospective studies; vaccination; Show all 4 Subjects
Abstract:
... With an uprising influence of social media platforms like Twitter and Instagram a multitude of worldwide accessible information is available. Since the beginning of COVID-19 pandemic the exchange of medical information about several topics related to this infectious disease and its vaccination has increased rapidly. The purpose of this investigation was to assess the content associated with COVID- ...
live vaccines, etc ; BCG vaccine; immunogenicity; tuberculosis; vaccination; Show all 5 Subjects
Abstract:
... The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and whether this new information can be exploited to improve its efficacy, by enhancing its ability to induce either antige ...
vaccines, etc ; epitopes; gene transfer; sequence diversity; virology; Show all 5 Subjects
Abstract:
... The sequence diversity of HIV-1 is the biggest hurdle for the design of a prophylactic vaccine. Mosaic (Mos) antigens consisting of synthetically shuffled epitopes from various HIV-1 strains are currently tested in the clinical vaccine trial Mosaico (NCT03964415). Besides adenovirus vectors encoding variants of Mos.Gag-Pol and soluble Mos.Env proteins, the Mosaico vaccine entails vectors mediating ...
vaccines, etc ; adjuvants; biocompatible materials; dendrimers; evolution; peptides; Show all 6 Subjects
Abstract:
... Dendrimers are well-defined, highly branched, multivalent and monodisperse molecules which host a range of attractive, yet functional, chemical and biological characteristics. A dendrimers accessible surface groups enable coupling to different functional moieties (e.g., antibodies, peptides, proteins, etc), which is further assisted by the dendrimers tailored size and surface charge. This adaptabi ...
vaccines, etc ; antigens; phosphates; polysaccharides; product quality; serotypes; Show all 6 Subjects
Abstract:
... Several glycoconjugate vaccines have been licensed or are currently in clinical development to prevent bacterial infections. Here we report the development of a single analytical assay to quantify the conjugated saccharide content, as alternative to two separated total and free (unconjugated) saccharide assays used so far, for a quadrivalent conjugate vaccine containing meningococcal serogroup A p ...
D. Scott LaMontagne; Portia Manangazira; Joan Marembo; Colline Chigodo; Coscar Zvamashakwe; Emma Tshuma; Evelyn Marima; Kenneth Chindedza; Ernest Ndlela; Jessica Mooney
vaccines, etc ; surveys; uterine cervical neoplasms; vaccination; Zimbabwe; Show all 5 Subjects
Abstract:
... Zimbabwe has one of the highest incidence rates of cervical cancer in the world – 61.7 per 100,000 women. The government of Zimbabwe introduced bivalent HPV vaccine with a 0,12 month schedule to all 10–14 year old girls using a pulsed-campaign approach in May 2018 (dose 1) and May 2019 (dose 2). In August 2019, we conducted a population-based, two-stage cluster survey of households with girls who ...
Lauri E. Markowitz; Mélanie Drolet; Rayleen Lewis; Philippe Lemieux-Mellouki; Norma Perez; Mark Jit; Julia M. Brotherton; Gina Ogilvie; Aimée R. Kreimer; Marc Brisson
vaccines, etc ; Papillomaviridae; humans; risk; systematic review; vaccination; Show all 6 Subjects
Abstract:
... Human papillomavirus (HPV) vaccines were first licensed as a three-dose series. Two doses are now widely recommended in some age groups; there are data suggesting high efficacy with one dose. We updated a systematic literature review of HPV vaccine effectiveness by number of doses in observational studies. We searched Medline and Embase databases from January 1, 2007, through September 29, 2021. D ...