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- van Oostrom, Conny TM., et al. Show all 3 Authors
- Food and chemical toxicology 2020 v.140 pp. 111284
- DNA replication; aromatic compounds; aryl hydrocarbon receptors; cumulative risk assessment; dioxins; dose response; embryonic stem cells; enzyme inhibition; estrogen receptors; extracellular matrix; fluorouracil; histone deacetylase; mechanism of action; methylmercury compounds; neural crest; oxidative stress; perfluorooctane sulfonic acid; retinoids; rodents; teratogenicity; triazoles; valproic acid
- ... The embryonic stem cell test (EST) was applied to evaluate dose addition in combined exposures of teratogenic compounds in the EFSA-defined cumulative assessment group “craniofacial malformations”, which was one of the selected cases in the EU-H2020 project “EuroMix”. Test compounds were selected through reported effects in rodents, and represented a wide variety of chemical families and modes of ...