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1. Enhancing the performance of sterile filtration for viral vaccines and model nanoparticles using an appropriate prefilter

Author:
Neil Taylor; Wanli (Justin) Ma; Adam Kristopeit; Sheng-Ching Wang; Andrew L. Zydney
Source:
Journal of membrane science 2022 v.647 pp. 120264
ISSN:
0376-7388
Subject:
viral vaccines,   etc   ; bioprocessing; filtration; live vaccines; porosity;     Show all 5 Subjects
Abstract:
... Prefilters are widely used to enhance the performance of normal flow filtration steps in bioprocessing; however little is known about the potential benefits of prefiltration in the sterile filtration of viral vaccines and other large particle biotherapeutics. Sterile filtration experiments were performed with a live-attenuated viral vaccine and model nanoparticle suspension, both of which have a s ...
DOI:
10.1016/j.memsci.2022.120264

2. Effectiveness of Live-Attenuated Genotype III Japanese Encephalitis Viral Vaccine against Circulating Genotype I Viruses in Swine

Author:
Yi-Chin Fan; Yi-Ying Chen; Jo-Mei Chen; Chienjin Huang; Mei Huang; Shyan-Song Chiou
Source:
Viruses 2022 v.14 no.1 pp. -
ISSN:
1999-4915
Subject:
viral vaccines,   etc   ; encephalitis; fetal death; genotype; live vaccines; public health; viruses;     Show all 7 Subjects
Abstract:
... Expansion of genotype I (GI) Japanese encephalitis viruses (JEV) has resulted in the replacement of the dominant genotype III (GIII) viruses, raising serious public health concerns for using GIII virus-derived vaccines to effectively control JEV epidemics. Therefore, this study used swine as the model to estimate the effectiveness of GIII live-attenuated vaccine against GI virus infection by compa ...
DOI:
10.3390/v14010114

3. Development of an Aptamer-Based Electrochemical Microfluidic Device for Viral Vaccine Quantitation

Author:
Tyler Chozinski; B. Scott Ferguson; William Fisher; Shencheng Ge; Qiang Gong; Hui Kang; John McDermott; Alexander Scott; Wentao Shi; Jeremiah J. Trausch; Thorsten Verch; Matthew Vukovich; Jinpeng Wang; J. Emma Wu; Qin Yang
Source:
Analytical chemistry 2022 v.94 no.16 pp. 6146-6155
ISSN:
1520-6882
Subject:
viral vaccines,   etc   ; analytical chemistry; electrochemistry; median effective concentration; oligonucleotides; portable equipment; quality control; standard deviation;     Show all 8 Subjects
Abstract:
... Global deployment of vaccines poses significant challenges in the distribution and use of the accompanying immunoassays, one of the standard methods for quality control of vaccines, particularly when establishing assays in countries worldwide to support testing/release upon importation. This work describes our effort toward developing an integrated, portable device to carry out affinity assays for ...
DOI:
10.1021/acs.analchem.1c05093

4. Enhanced High Mutation Rate and Natural Selection to Produce Attenuated Viral Vaccine with CRISPR Toolkit in RNA Viruses especially SARS-CoV-2

Author:
Saleh Jamehdor; Sina Naserian; Ali Teimoori
Source:
Infection, genetics, and evolution 2022 v.97 pp. 105188
ISSN:
1567-1348
Subject:
viral vaccines,   etc   ; RNA; Severe acute respiratory syndrome coronavirus 2; coculture; genome; infection; live vaccines; mutation rate; natural selection;     Show all 9 Subjects
Abstract:
... The best and most effective way to combat pandemics is to use effective vaccines and live attenuated vaccines are among the most effective vaccines. However, one of the major problems is the length of time it takes to get the attenuated vaccines. Today, the CRISPR toolkit (Clustered Regularly Inerspaced Short Palindromic Repeats) has made it possible to make changes with high efficiency and speed. ...
DOI:
10.1016/j.meegid.2021.105188

5. A Brighton Collaboration standardized template with key considerations for a benefit/risk assessment for an inactivated viral vaccine against Chikungunya virus

Author:
Libia Milena Hernandez; K. Sumathy; Sushant Sahastrabuddhe; Jean-Louis Excler; Sonali Kochhar; Emily R. Smith; Marc Gurwith; Robert T. Chen; Benefit-Risk Assessment of VAccines by TechnolOgy Working Group (BRAVATO, ex-V3SWG)
Source:
Vaccine 2022 v.40 no.35 pp. 5263-5274
ISSN:
0264-410X
Subject:
viral vaccines,   etc   ; COVID-19 infection; Chikungunya virus; databases; immunogenicity; influenza; pandemic; risk; risk assessment; rivers; thermal stability; viruses; India;     Show all 13 Subjects
Abstract:
... Inactivated viral vaccines have long been used in humans for diseases of global health threat (e.g., poliomyelitis and pandemic and seasonal influenza) and the technology of inactivation has more recently been used for emerging diseases such as West Nile, Chikungunya, Ross River, SARS and especially for COVID-19. The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO ...
DOI:
10.1016/j.vaccine.2022.06.006

6. Long-term efficacy of nasal vaccination against enteric red mouth (ERM) disease and infectious hematopoietic necrosis (IHN) in juvenile rainbow trout (Oncorhynchus mykiss)

Author:
Jie Ma; Elisa Casadei; Timothy J. Bruce; Ali Sepahi; Kenneth D. Cain; Irene Salinas
Source:
Vaccine 2022 v.40 no.2 pp. 229-238
ISSN:
0264-410X
Subject:
viral vaccines,   etc   ; Infectious hematopoietic necrosis virus; Oncorhynchus mykiss; Yersinia ruckeri; antibodies; blood serum; fish; juveniles; live vaccines; mortality; mouth; necrosis; nose; spleen; vaccination;     Show all 15 Subjects
Abstract:
... Previous research demonstrated that bacterial and viral vaccines delivered via the nasal route in rainbow trout (Oncorhynchus mykiss) at 7 and 28 days post-vaccination are highly protective (>95% protection). Long-term protection following nasal vaccination in teleosts has not been evaluated. The goal of this study was to assess efficacy and immune responses at 6 months (mo) post-vaccination (mpv) ...
DOI:
10.1016/j.vaccine.2021.11.077

7. Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2

Author:
Gatot Soegiarto; Laksmi Wulandari; Dewajani Purnomosari; Karin Dhia Fahmita; Hendra Ikhwan Gautama; Satrio Tri Hadmoko; Muhammad Edwin Prasetyo; Bagus Aulia Mahdi; Nur Arafah; Dewi Prasetyaningtyas; Pujo Prawiro Negoro; Cita Rosita Sigit Prakoeswa; Anang Endaryanto; Desak Gede Agung Suprabawati; Damayanti Tinduh; Eka Basuki Rachmad; Erwin Astha Triyono; Joni Wahyuhadi; Catur Budi Keswardiono; Feby Elyana Wardani; Fitriyah Mayorita; Nunuk Kristiani; Ari Baskoro; Deasy Fetarayani; Wita Kartika Nurani; Delvac Oceandy
Source:
Vaccine 2022 v.40 no.30 pp. 4046-4056
ISSN:
0264-410X
Subject:
viral vaccines,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibodies; antibody formation; blood; blood pressure; health services; hypertension; questionnaires; retrospective studies; vaccination; viruses;     Show all 13 Subjects
Abstract:
... Several types of vaccines have been developed to prevent the coronavirus disease 2019 (COVID-19). It is important to understand whether demographic and clinical variables affect the effectiveness of various types of vaccines. This study analysed the association between demographic/clinical factors, antibody response and vaccine effectiveness in healthcare workers vaccinated with inactivated virus. ...
DOI:
10.1016/j.vaccine.2022.05.059

8. In-line monitoring of surfactant clearance in viral vaccine downstream processing

Author:
Jessie Payne; James Cronin; Manjit Haer; Jason Krouse; William Prosperi; Katherine Drolet-Vives; Matthew Lieve; Michael Soika; Matthew Balmer; Marina Kirkitadze
Source:
Computational and Structural Biotechnology Journal 2021 v.19 pp. 1829-1837
ISSN:
2001-0370
Subject:
viral vaccines,   etc   ; biotechnology; filtration; multivariate analysis; surfactants;     Show all 5 Subjects
Abstract:
... The goal of this study is to examine the suitability of in-line infrared measurements to monitor, in real-time, surfactant concentration in the viral vaccine drug substance during a 50KDa tangential flow filtration (TFF) process.A ReactIR™ 702L instrument was used to gather spectra of process off-line samples and reference materials to assess the feasibility of monitoring surfactant concentration ...
DOI:
10.1016/j.csbj.2021.03.030

9. Towards a Systems Immunology Approach to Understanding Correlates of Protective Immunity against HCV

Author:
Naglaa H. Shoukry
Source:
Viruses 2021 v.13 no.9 pp. -
ISSN:
1999-4915
Subject:
viral vaccines,   etc   ; Hepatitis C virus; epigenetics; hepatitis C; immune response; serology; transcriptomics; vaccine development;     Show all 8 Subjects
Abstract:
... Over the past decade, tremendous progress has been made in systems biology-based approaches to studying immunity to viral infections and responses to vaccines. These approaches that integrate multiple facets of the immune response, including transcriptomics, serology and immune functions, are now being applied to understand correlates of protective immunity against hepatitis C virus (HCV) infectio ...
DOI:
10.3390/v13091871

10. Evaluating Nanoparticle Hydrophobicity Using Analytical Membrane Hydrophobic Interaction Chromatography

Author:
Neil Taylor; Wanli Ma; Adam Kristopeit; Sheng-ching Wang; Andrew L. Zydney
Source:
Analytical chemistry 2022 v.94 no.24 pp. 8668-8673
ISSN:
1520-6882
Subject:
viral vaccines,   etc   ; adhesion; analytical chemistry; gene therapy; hydrophobic interaction chromatography; hydrophobicity; live vaccines; porosity; thermoplastics;     Show all 9 Subjects
Abstract:
... Nanoparticle hydrophobicity is a key factor controlling the stability, adhesion, and transport of nanoparticle suspensions. Although a number of approaches have been presented for evaluating nanoparticle hydrophobicity, these methods are difficult to apply to larger nanoparticles and viruses (>100 nm in size) that are of increasing importance in drug delivery and gene therapy. This study investiga ...
DOI:
10.1021/acs.analchem.2c00710

11. Antibodies Elicited in Response to a Single Cycle Glycoprotein D Deletion Viral Vaccine Candidate Bind C1q and Activate Complement Mediated Neutralization and Cytolysis

Author:
Maria Luisa Visciano; Aakash Mahant Mahant; Carl Pierce; Richard Hunte; Betsy C. Herold
Source:
Viruses 2021 v.13 no.7 pp. -
ISSN:
1999-4915
Subject:
viral vaccines,   etc   ; antiserum; blood serum; clinical trials; complement; cytolysis; cytotoxicity; glycoproteins; herpes simplex; immunization; neutralization; phagocytosis; serotypes; viruses;     Show all 14 Subjects
Abstract:
... Herpes simplex virus (HSV) prevention is a global health priority but, despite decades of research, there is no effective vaccine. Prior efforts focused on generating glycoprotein D (gD) neutralizing antibodies, but clinical trial outcomes were disappointing. The deletion of gD yields a single-cycle candidate vaccine (∆gD-2) that elicits high titer polyantigenic non-gD antibodies that exhibit litt ...
DOI:
10.3390/v13071284

12. Isolation and phylogenetic analysis of the canine distemper virus from a naturally infected dog in China

Author:
Hongliang Zhang; Peipei Meng; Xiaoming Song; Shuguang Li; Ruimei Yang; Chuanmei Zhang; Hu Shan; Yongjun Wen
Source:
Indian journal of animal research 2021 v.55 no.6 pp. 629-635
ISSN:
0976-0555
Subject:
viral vaccines,   etc   ; Canine morbillivirus; antigenic variation; canine distemper; dogs; genotype; glycosylation; hemagglutinins; neutralization tests; nucleotide sequences; phylogeny; sequence analysis; China;     Show all 13 Subjects
Abstract:
... Canine distemper virus (CDV) can infect a variety of predators, such as Canidae, Mustelidae and Procyonidae family and cause high morbidity and mortality. Genetic/antigenic heterogeneity has been observed among various CDV strains, notably in the haemagglutinin (H) gene. Based on sequence analysis of the H gene, wild-type CDV strains can be divided into distinct genotypes. We used Vero/SLAM cells ...
DOI:
10.18805/ijar.B-1298

13. Parenteral Antioxidant Supplementation at Birth Improves the Response to Intranasal Vaccination in Newborn Dairy Calves

Author:
Arpita Nayak; Angel Abuelo
Source:
Antioxidants 2021 v.10 no.12 pp. -
ISSN:
2076-3921
Subject:
viral vaccines,   etc   ; Bovine alphaherpesvirus 1; antioxidants; blood serum; immunoglobulin A; morbidity; mortality; neonates; nose; oxidative stress; placebos; secretion; vaccination; viruses;     Show all 14 Subjects
Abstract:
... Newborn calves experience oxidative stress throughout the first month of their life, which is known to decrease lymphocyte functions relevant to vaccine responsiveness. Thus, this study aimed to determine the extent to which parenteral antioxidant supplementation given at birth improves the response to an intranasal viral vaccine in the first month of life of newborn dairy calves. For this, 21 cal ...
DOI:
10.3390/antiox10121979

14. The origins and genomic diversity of American Civil War Era smallpox vaccine strains

Author:
Ana T. Duggan; Jennifer Klunk; Ashleigh F. Porter; Anna N. Dhody; Robert Hicks; Geoffrey L. Smith; Margaret Humphreys; Andrea M. McCollum; Whitni B. Davidson; Kimberly Wilkins; Yu Li; Amanda Burke; Hanna Polasky; Lowell Flanders; Debi Poinar; Amogelang R. Raphenya; Tammy T. Y. Lau; Brian Alcock; Andrew G. McArthur; G. Brian Golding; Edward C. Holmes; Hendrik N. Poinar
Source:
Genome biology 2020 v.21 no.1 pp. 175
ISSN:
1474-760X
Subject:
viral vaccines,   etc   ; Poxviridae; genetic variation; genome; smallpox; vaccination;     Show all 6 Subjects
Abstract:
... Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes ...
DOI:
10.1186/s13059-020-02079-z

15. Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

Author:
Chang Liu; Helen M. Ginn; Wanwisa Dejnirattisai; Piyada Supasa; Beibei Wang; Aekkachai Tuekprakhon; Rungtiwa Nutalai; Daming Zhou; Alexander J. Mentzer; Yuguang Zhao; Helen M.E. Duyvesteyn; César López-Camacho; Jose Slon-Campos; Thomas S. Walter; Donal Skelly; Sile Ann Johnson; Thomas G. Ritter; Chris Mason; Sue Ann Costa Clemens; Felipe Gomes Naveca; Valdinete Nascimento; Fernanda Nascimento; Cristiano Fernandes da Costa; Paola Cristina Resende; Alex Pauvolid-Correa; Marilda M. Siqueira; Christina Dold; Nigel Temperton; Tao Dong; Andrew J. Pollard; Julian C. Knight; Derrick Crook; Teresa Lambe; Elizabeth Clutterbuck; Sagida Bibi; Amy Flaxman; Mustapha Bittaye; Sandra Belij-Rammerstorfer; Sarah C. Gilbert; Tariq Malik; Miles W. Carroll; Paul Klenerman; Eleanor Barnes; Susanna J. Dunachie; Vicky Baillie; Natali Serafin; Zanele Ditse; Kelly Da Silva; Neil G. Paterson; Mark A. Williams; David R. Hall; Shabir Madhi; Marta C. Nunes; Philip Goulder; Elizabeth E. Fry; Juthathip Mongkolsapaya; Jingshan Ren; David I. Stuart; Gavin R. Screaton
Source:
Cell 2021 v.184 no.16 pp. 4220-4236.e13
ISSN:
0092-8674
Subject:
viral vaccines,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antigenic variation; antiserum; monoclonal antibodies; neutralizing antibodies; vaccination; viral antibodies; viral antigens;     Show all 10 Subjects
Abstract:
... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 has contributed to the current wave of infection ravaging the Indian subcontinent and has been designated a variant of concern in the United Kingdom. Here we s ...
DOI:
10.1016/j.cell.2021.06.020

16. Serological Responses of Raccoons and Striped Skunks to Ontario Rabies Vaccine Bait in West Virginia during 2012–2016

Author:
Shylo R. Johnson; Dennis Slate; Kathleen M. Nelson; Amy J. Davis; Samual A. Mills; John T. Forbes; Kurt C. VerCauteren; Amy T. Gilbert; Richard B. Chipman
Source:
Viruses 2021 v.13 no.2 pp. -
ISSN:
1999-4915
Subject:
viral vaccines,   etc   ; Mephitis mephitis; Procyon lotor; Rabies lyssavirus; baits; disease control; edible vaccines; neutralizing antibodies; oral vaccination; rabies; seroprevalence; skunks; wildlife; West Virginia;     Show all 14 Subjects
Abstract:
... Since the 1990s, oral rabies vaccination (ORV) has been used successfully to halt the westward spread of the raccoon rabies virus (RV) variant from the eastern continental USA. Elimination of raccoon RV from the eastern USA has proven challenging across targeted raccoon (Procyon lotor) and striped skunk (Mephitis mephitis) populations impacted by raccoon RV. Field trial evaluations of the Ontario ...
DOI:
10.3390/v13020157

17. Evaluation of adjuvant activity of Astragaloside VII and its combination with different immunostimulating agents in Newcastle Disease vaccine

Author:
Nilgun Yakubogullari; Furkan Ozan Coven; Nusin Cebi; Fethiye Coven; Nejdet Coven; Rukan Genc; Erdal Bedir; Ayse Nalbantsoy
Source:
Biologicals 2021 v.70 pp. 28-37
ISSN:
1045-1056
Subject:
viral vaccines,   etc   ; Astragalus; Newcastle disease; Quillaja; albino; astragalosides; emulsions; humoral immunity; immune response; immunoglobulin G; immunostimulants; interleukin-2; interleukin-4; metabolites; polysaccharides; splenocytes; squalene;     Show all 17 Subjects
Abstract:
... Astragaloside VII (AST-VII), a major cycloartane saponin isolated from Turkish Astragalus species, turned out to be one of the most active metabolites demonstrating Th1/Th2 balanced immune response. As Quillaja saponins are extensively used in adjuvant systems, this study made an attempt to improve AST-VII based adjuvant systems by using different immunostimulatory/delivery agents (monophosphoryll ...
DOI:
10.1016/j.biologicals.2021.01.005

18. Effects of Multivalent BRD Vaccine Treatment and Temperament on Performance and Feeding Behavior Responses to a BVDV1b Challenge in Beef Steers

Author:
Paul Smith; Gordon Carstens; Chase Runyan; Julia Ridpath; Jason Sawyer; Andy Herring
Source:
Animals 2021 v.11 no.7 pp. -
ISSN:
2076-2615
Subject:
viral vaccines,   etc   ; Angus; Nellore; animal performance; beef cattle; body weight; bovine viral diarrhea; crossbreds; dry matter intake; inactivated vaccines; intranasal administration; live vaccines; steers; temperament; vaccination;     Show all 15 Subjects
Abstract:
... This study examined the effects of multivalent respiratory vaccine treatment (VT) and animal temperament classification on feeding behavior traits, feed intake and animal performance in response to a bovine viral diarrhea virus (BVDV) challenge. Nellore–Angus crossbred steers (n = 360; initial body weight (BW) 330 ± 48 kg) were assigned to one of three vaccine treatments: non-vaccinated (NON), mod ...
DOI:
10.3390/ani11072133

19. A reversed phase HPLC-UV method for the simultaneous determination of residual formaldehyde and Triton X-100 in vaccine products

Author:
Burki Rajendar; M V N Janardhan Reddy; Ch N V Suresh; Sampreeth kumar Gambheerrao; Ramesh V. Matur
Source:
Journal of chromatography 2021 v.1184 pp. 122977
ISSN:
1570-0232
Subject:
viral vaccines,   etc   ; Haemophilus; asymmetry; formaldehyde; hepatitis B; humans; liquids; octoxynol; purification methods;     Show all 9 Subjects
Abstract:
... Many of the inactivated viral vaccines for human and animal use are manufactured using formaldehyde as an inactivating agent. Apart from formaldehyde, Triton X-100 is also one of the chemicals commonly used in viral vaccine manufacturing. Triton X-100 is typically used to extract the cell-associated viruses and / or components during manufacturing process. The concentration of formaldehyde and Tri ...
DOI:
10.1016/j.jchromb.2021.122977

20. Four‐step approach to efficiently develop capillary gel electrophoresis methods for viral vaccine protein analysis

Author:
Lars Geurink; Ewoud van Tricht; Justin Dudink; Bojana Pajic; Cari E. Sänger – van de Griend
Source:
Electrophoresis 2021 v.42 no.1-2 pp. 10-18
ISSN:
0173-0835
Subject:
viral vaccines,   etc   ; gel electrophoresis; gels; glycoproteins; influenza; pH; temperature; vaccine development; virion; wavelengths;     Show all 10 Subjects
Abstract:
... Vaccines against infectious diseases are urgently needed. Therefore, modern analytical method development should be as efficient as possible to speed up vaccine development. The objectives of the study were to identify critical method parameters (CMPs) and to establish a set of steps to efficiently develop and validate a CE‐SDS method for vaccine protein analysis based on a commercially available ...
DOI:
10.1002/elps.202000107